Document BR9GrXgeErLO0kVnVgVnEkzdw

THE DOW CHEMICAL COMPANY November 25, 1986 MIDLAND, MICHIGAN 48674 Ms Carol S^ack CHEMICAL MANUFACTURERS ASSOCIATION 2501 M. Street, N.W. Washington, DC 20037 Dear Ms. Stack: Attached is a copy of a letter I received from Mr. Bennett regard ing the Vinyl Chloride Study. Dr. Ted Torkelson requested that I send you a copy of the letter. If you should have any question, please contact: Dr. Ted Torkelson 3865 John Ln Midland, MI 48640 Phone: (517) 835-1354 Sincerely, Angie Grzegorczyk Epidemiology, H&ES 1803 Building Midland, MI 48674 Phone: (517) 636-2718 Attachment CMA 006421 Hiilhouse Site PO Box No 4 Thornton - Cleveleys Blackpool FV5 4QD Telephone (0253) 861632Direct line (Seer tary 861370) (0253) 861444 Switchboard 6 632Extension Number Facsimile (0253) 864687 Telex 67463 Iciplast Clvlys icn Imperial Chemical S59 Industries ^ Dir Medical Department Mrs Angie Grzegorczyk Epidemiology, H & ES The Dow Chemical Company 1803 Building MIDLAND Michigan 4867^ USA Your ref Our ref BB/MO Date 19 Nov & Dear Mrs. Grzegorczyk, FINAL REPORT ON CMA UPDATE OF VINYL CHLORIDE STUDY Thank you very much for sending me a copy of the above report, together with a copy for Sir Richard Doll. I have posted Sir Richard's copy on to him. I very much appreciate receiving this report, in which I am very interested. Yours sincerely, B BENNETT M.A. M.B., B.Ch., B.a.O. D.Obst.R.C.O.G. D.I.H., M.F.O.M. CMA 006422 LIVER ANGIOSARCOMA. CASES OCNFUSNTIAL KFX/ASL - ASL ADDRESS CKOJLAXICN OF REGISTER ADAMS Dr A Ross Air Products, Allentown, Pa, USA BAGSHAW Dr I M M Norsk Hydro, Newtai Aycllffe, IX BAND Dr P R Cancer Control Agency of British Columbia, Vancouver, Canada BARNES Jnr W C Monsanto, St Louis, Missouri, USA BARR Dr J T Air Products, Allentown, Pa, USA BARRAI Dr G AEGRP, Conmentry, France BAXTER Dr Peter EMAS, London, IX BEAUPRE M Govemnent of Qiebec Cancer Registry, Canada BENECH Dr M Naphtachimie, Lavera, France BENNETT Dr B ICI Hillhouse, UC BERTAZZI Dr P Inst of Occupational Health, Milan University, Italy BESCHE Dr Dynanit Nobel, Troisdorf, Germaiy BISFCP Dr C EMAS, Bootle, IX BORRELLI F E Georgia Gulf, Delaware City, USA BOXER R W Formosa Plastics, Delaware City, USA BURGESS Mr David ICI Anericas, Wilmington, Delaware USA BXREN Dr David CARTER Dr J T CELLA Mr C CHANCE Mr M CLAUS Mr P G CLAYTON Mr H Kemanord, Stockholm, Sweden EMAS, London, IX Enichem Poliaeri, Milan, Italy ICI Runcorn, IX APME, Brussels, Belgian Norsk Hydro, Newtcn Aycllffe, IK n A>-r ' SubOect -to - ^"O * JO 14^ Z\ 'xifor T.o. oo :r ot CoUl L ana- OONIASSOT Dr J C Chloe Chimie, Saint-Fons, France DAVIES Mr J G ICI, Everberg, Belgian (2) DE SLOOVER Dr Solvay & Cie, Brussels, Belgian DE VOS Mr A J ICI Everberg, Belgian DIETZ Dr HW B F Goodrich, Akron, Ohio, USA DOIX Sir Richard Imperial Cancer Research Fund, Oxford University, IK DCMERQWSKL S L Dow Chemical, Midland, Michigan, USA DUPONT Mr G AH, Brussels, Belgian EMUNGER Mr H VKE, Frankfurt, Germany ERtET Dr W Berufsgenossenschaft der Chanischen Industries, Numberg, Germany FALK, Dr H Chronic Diseases Dlv, US Dept of Health & Honan Services, Atlanta, USA FERGUSON Dr D M ICI Americas, Wilmington, Delaware, USA FORMAN Dr D Imperial Cancer Research Fund, Oxford University, IK FRASE R W DiversiTech General, Akrcn, Ohio, USA FRIEDEL Dr H P Berufsgenossenschaft der Chanischen Industries, Heidelberg, Germany GOLBERG Prof L Duke Univ Medical Center, Durham, North Carolina, USA GOSZTONYI Jnr Dr R E Termeco Chemicals, Plscataway, New Jersey, USA GOTTESMAN R T The Vinyl Institute, New York, USA HARRIS Dr W D Unlroyal Inc, Mlddlebury, Connecticut, USA HILL Dr G B Alberta Cancer Board, Ednonton, Canada HH1MAN Dr D W Diamond Shmnrock Corp, Dallas, Texas, USA HINDERER Dr R K BF Goodrich, Cleveland, Ctiio, USA HXGSCN Mr J EMAS, Bootle, IK HOGG Dr W A Imperial Oil Ltd, Sarnia, Ontario, Canada HOWARD Dr J K University of Otago School of Medicine, Wellington, New Zealand HUMPHRY Dr N F ICI Australia, Melbourne, Australia JADVERT Mr J Chloe Chimie, Paris, France JERVIS Mr H R ICI Mlllhank, Larina IK KARRH Dr Bruce Dupont, Wilmington, Delaware USA KREUGER Dr R A BF Goodrich, Akron, Chio, USA LALOINE Dr J P Solvay, Brussels, Belgian LAMWM Dr John Daw Chemical Europe, Horgen, Switzerland LAWRENCE Mr J SPI, New York, USA LAHRENCE-JONES Sir Christopher, Chief Medical Officer, ICI, London IK IBEDrFI Victoria Hospital, Blackpool, Lancs, IK LELBACH Prof VK University of Bonn, Wfest Germany LEVEQCE Dr G CDF Chimie, AZF, Bully-lea-MInag, France LEVISON Dr D A St Bartholomew's Hospital, London, IK LEWIS Dr P LOUVUR Mr Chemical Industries Association, London, IK Solvay, Brussels, Bigiin 006423 LUSSATO Dr J Atochem, France 2- - WPX/ASL - ASL ADDRESS,2 MAILLARD Dr J M Medizinsche Abteilung, Luzern, Switzerland MALHOIRA Anna Statistics Canada, Ottawa MALTONI Prof C Institute di Oncologia, Bologna, Italy MAUBE Prof Lo Medil-Anic-S, Milan, Italy MHTHJSSI Dr R Montedison, Milan, Italy MIDDLETON D Norsk Hydro, Newton Ayrltffe, UK M3KKA Mr Neste Oy, Espoo, Finland M3NIESAN0 Dr R IARC, Lyons, France MOTTI Dr A A Duperial SAIC, Buenos Aires, Argentina MINN Dr A Montanto, Brussels, Belgium MJH3Z MDUTON Dr M Rio Rodano, Madrid, Spain MacSVEEN Prof RNM Western Infirmary, Glasgow, Scotland NAKAMJRA S Japanese FVC Association, Tokyo O'SULLIVAN Dr JJ IQ Runcorn, UK OLSON H G VC Safety Assodatim, Louisiana, USA CWEN Dr R Trades Union Congress, London, IK PADDLE Dr G M Id Central Medical Group, Alderley Park, IK PA3JALUN3A Dr S tfontedison, Milan, Italy F0FFER Dr Hans Mount Sinai Medical Center, New York, USA POSSBERG Dr J Wacker-Cbemie, Mmich, Germany HJECH Dr A M Arochem, Brlgnoud, France FJRIHAM Dr J Canadian Centre for Occupational Health & Safety, Hamilton, Canada RAMEAU) Dr J SP Recherches, Antony, France RAN3ES P Norsk Hydro, Porsgrunn, Norway RICKARD Dr P ROBSCN Mrs D Rhone Poulenc, Roussillon, France Saskatchewan Cancer Foundation, Regina, Canada _ v- RODRIGUES Dr MJF Id, Sao Paulo, Brazil ROUSH Dr G Monsanto, St Louis, Missouri, USA RUIY Dr J Atochan, St Aufaan, France SALG Dr J NIOSH, Cincinnati, USA SASAOd Dr R IARC, Lyons, France SCHEFFERS Dr M L D31/CVMD, Geleen, Holland SCHHFER Dr H University of Manitoba, Winnipeg, Canada B'- V''' ,S>" ^K, A ey V -3 i SEROME Dr D Diamond Shanrock, Dallas, USA SHAH Dr Has CMA, Washington DC, USA SXGRIST Dr J Shell Chinde, Berne L'Etang, France SMITH Dr E Division of Enviroonental Health, Wbrld Health Organisation, Geneva, Switzerland SMITH Dr P M Llandough Hospital, Penarth, UK SPIRIAS Dr R Nd/NIH, Bethesda, Marylanl, USA STAFFORD Dr J Somerset, UK SIAIWEQGER Mr BASF, Ludwigshafen, Germany TAMBURRO Prof CH University of Louisville, USA TER HAAR Dr Gary Ethyl Corporation, Baton Rouge, Louisiana, USA 1EFWIESQ1 Dr B Chemische Werke HiLs, Kreis Recklinghatsen, Germany THERIAULT Dr Gllles MsGUL University, Montreal, Canada THEESS Prof Dr AM BASF, Ludwigshhafen, Germany TH11S-EVENSCR Dr E Norsk Hydro, Porsgrunn, Norway THMSCN Dr D H Cancer Treatment & Research Foundation, Halifax, Nova Scotia, Canada TCRDOIR Dr W Shell, An Den Haag, Holland VAN DER FEEHE Dr H J AECI, Sasolburg, South Africa WA1LACE J R Esso, Samla, Ontario, Canaria WALTFMA1E H BF Goodrich, Cleveland, Ohio, Usa WEJEQNG S 0 Kananord, Stockholm, Sweden WffiELER Dr D J Id HUlhouse, UK WHEELER R N Union Carbide, South Charleston, USA WHISTON Dr J Id HUlhouBe, UK WHITE K H Duperial, Buenos Aires, Argentina WTLHGKI 0 Electrochemical Industries, Acre, Israel WILLIAMS Dr IHJ BP Ctmmicala, Penarth, IK WILSON Prof R Harvard University, Cambridge, Massachusetts, USA WRIGHT Dr A P Id Wilton, IK YOK J Id Everberg, Belgian Ftcm: Dr B Bennett, Medical Department, Imperial Chemical Industries Pic Hillhouse Site, PO Bax 4, ThorntorrCleveleys, Blackpool FY5 4<E, IK. CMft 006424 February 1986 CONFIDENTIAL REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVER DUE TO EXPOSURE TO VINYL CHLORIDE - REVIEW DATE 1 JANUARY 1966 PREFACE: Acknowledgments, significant changes and comments 1. The new cases in the Register are the following : France Germany UK 18 23* 24, 25, 26, 2? 11, 12 2. There are amendments from the previous Register against the following cases: Germany 21, 22 US 36, 38 3. I would like to thank Dr De Sloover, Dr D M J Williams and Dr Friedel for informing me of new cases. 4. For the case corrections I would like to thank Dr Friedel, Mr J T Barr and Mr R W Frase. 5. For other corrections and information, thanks to Dr D Forman, Mr J T Barr, Mr T H Sutherland and Mr N F Humphry. 6. I should be very grateful if all recipients of the Register could continue to keep me fully informed of any new cases, or, if they should hear of other Companies who have acquired a case of ASL, it would be much appreciated if I could be notified by the appropriate person. It is extremely helpful if new information is supplied in tabulated form, using the headings in the Register as far as possible. 7. I would like to thank the many people who have suggested research topics, and should be grateful if I could be kept up to date. 8. I shall be happy to supply to any recipient of the Register a copy of the Paper "Exposure to Vinyl Chloride and Angiosarcoma of the Liver; a report of the Register of cases" by Dr David Forman, myself. Dr John Stafford and Sir Richard Doll, published in the British Journal of Industrial Medicine, November 1985 (42: 750-753) Dr Brian Bennett Medical Department Imperial Chemical Industries pic Hillhous Site P 0 Box 4 Thornton-Cleveleys Blackpool FY5 4QD England February 1986 CO III1'11M TIAL Subject to Protective Order in Ross v. Conoco, Inc., Mo. 90-4837 14th Judicial District Court Calcasieu Parish, Louisiana CMA 0 0 6 4 2 5 CMA 0 0 6 4 2 6 Index Table Sequence Belgium * Canada Czechoslovakia France Germany Italy Japan Norway Sweden UK USA Yugoslavia Incidence of Cases per annum (Table l) Distribution of Cases by Country (Table 2) Pattern of Cases by Factory (Table 3) Latency Periods (Table 4A) Distribution of Latency Periods (Table 4B-4H) Annual Geographical Incidence (Table 5) IMPERIAL CHEMICAL INDUSTRIES PLC LIVER ANGIOSARCOMA CASES (REVIEW DATE - I JANUARY 1986) WPX/ASL 2 - LANCI0CASES.4 Page 1 2-3 4 5-8 9-14 15 16 17 18 19-21 22-28 29 30 31 32 33 34-40 ASL Case Numbers by year of Death (Table 6) ASL Case Numbers by year of first exposure (Table 7) Western Europe PVC Producers - Start-up Dates vs ASL Cases (Table 8) USA PVC Producers - Start-up Dates vs ASL Cases (Table 9) Canadian PVC Producers - Start-up Dates vs ASL Cases (Table 10) East European PVC Producers - Start-up Dates vs ASL Cases (Table 11) Japanese PVC Producers - Start-up Dates vs ASL Cases (Table 12) South & Central American PVC Producers - Start-Up Dates (Table 13) Australasian PVC Producers - Start-up Dates (Table 14) Page 42 43 44 45+46 47 48 49 50 51 _C0NFI])TIJTn j . J loss V. Oonov-o J'Hb j(,j/ ' Uu tr*/ nch, Order in ll0- 90-4037 LouiRCjaonu;rit 41 |Pa|* i , | J6ELCIIM IMPERIAL CHEMICAL IM1USYHUS PLC LIVER AugInearcoma Caaea - (Review Dace i l January 1906) WX/ASl-Jt - LANGIUCASKS t fc 2I 3 4 3 6 7 0 9 10 11 12 11 14 13 16 country and ICPIICNCS HO NAME Oft INITIALS DATE Of BUT* COMPANY PACTOftY FIRST VC UPOSURg DATE OP DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS Op EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL occurATIOH OTHER CAREER II1CHL1CHTS OTHER COMMENTS ; BELGIUM 01 I i i i 11.01.11 Solvay 00.07.30 00.03.76 61 /Wjec, 2s v> ,to Px c4tih CalcaSi 5o dic^j eu Par lsh> lAl Uo- 90 la Zt Ct COUr lS3? "fana IS 17 29.06.76 Yaa High Autocleauer Driller In a Hepatic teeta 14 yra foundry In Oct 1974 1936-196S (2 yra) were uornal. expoaed to Polyworksr Pa rear Retired 100 ppm i r 03 yra) Feb 1973 Cor S bra Uork In glass HuepJ tallaed par Say Ind. A clieml- Hay 1976 a ad cal Industry certainly Complete under Clinical ami 300 ppm career derailt. In 6 to 9m3 are g 1 veil In a paper by autaclavea ma-tKi Hublet et al In Arch. HeIg. expoaed to Med. Sue., 50-200 ppm 6 hra par IlyR. Med. Trav. Hed. day In 25m1 Leg. 1977 pages aut oclave* liJi-iiH 601-622 exposed to 50-200 ppm In sutu- clave room PI* 1975- 30 PF* RETIRED 1 Feb 1973 11 01 SI 19 09 40 Solvay n 3: > o o CK M NJ 10 OB 41 00.10.79 39 17 9 23 10 S3 Yaa 06.62-01. 63 01.67 -10.71 * 200 ppm Gli/day 04.61-12. 66 < 200 ppm Autocleaaer Fireman since 3 yra 3 me ha 10 71. Operator 3 yra 9mtla. let algu July 79t Thoracic pain 07.79. Hepatic teeta altered 10.79. Pualt tve eclwgraphy 11.79. iiupa (eciumy 02.tiU. iLliemutbe apy. Information tRiven in letter 1 Ho* 1964 !n Or De Stoover. ( jjoifri^Dr^rTi^Tj ^^ihiGci "to I'rot ooL ivu Grdor in Poss v. ^Conoco, Inc. , JJo. 90-4837 14fh Judicial District Court *** i Calcasieu Parish, Louisiana CANADA Mt 1 IHrrkUL Cltt.HlCiL immSTBIES H,C LIVED Anglusarcoae Caves - (Review DateJ 1 Jea 1906) tt 2 1 A 3 6 7 9 10 11 All dates une (IX eyetea DAY - MONTH - TEAR 12 13 WE/ASL 2 - UUtClOCASES, 1 H 15 16 COUNTRY AND umiNCi HO NAME OR INITIALS DATE Of USTN COMPANY FACTORY FIRST VC CirOSURK DATE OF DIAGNOSIS ACE AT DIACM0S1S YEARS OF EXPOSURE TO D1AGNOSIA YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER Careen fcllGHL ICH1S OTHER COMMENTS CAHADA 01 SHAUll UCAH 13.12.13 19AA 1453 41 11 11 02.09.55 Yea Re actor cleaoer Operator Smoke r polymerisation 02 06.03.14 mi 1437 4) 14 U 21,12.57 Yea Maintenance. Operator aiNvr Ight, pipe!1tter Worked overtime Smoker 03 26.0C.19 1941 1462 42 21 20 21.03.62 Yea Operator, foreaen Worked overt lee Non- tmubef 04 03.0A.14 1**5 1967 41 22 21 21.01.60 Yea Reactor cleaner Operator, forcaen, water cooling unit Worked overt| Smoker 03 07.03.11 mt I960 37 14 05 03.07.64 Yea Reactor cleaner Water cooling unit Wot bed uvertlae Smoker DA I5.I2.U 17 1971 51 24 23 10.04.?l Tee Reactor cleaner Maintenance, Millwright WurkeJ uvertIme Smoker * 07 04.11.14 1444 1972 SI 24 25 24.11.71 Yea Reactor cleaner Machine vtiop operator and poly unit Worked overtle Sauker oi 13,03.10 1441 1473 33 12 05 12.06.73 Ye* Reactor cleaner Maintenance machine ale>p in plant 25 yral Smukei fr<?00 VW3 04 14.07.2) 1446 1974 51 2ft 26 04.09.74 Ye* Furnace op. pipefitter Maintenance Worked overt tee Smoker 4 Paper by Dr t DELORME In Anaalea ^'AortMli petHologJqu* Parity 1970 Vol 23 Ho 2 ppl05-114 dales this cat* bad both a btpituia aud ASL elaulteneouely* W CD Page 3 C AHA DA Ibaat a IMPERIAL CHEMICAL INDUSTRIE PLC LIVER Aaglourcou Cam* - (Itvlw Data* l Jan 1306) DAf - MONTH ~ TEAR All dttci dm UK aysiM UPX/ASLJi - l.ANCIOCASBS.E I 1 j A 3A 7 s 9 10 11 12 13 14 15 It COUNTRY AW urliuct NO NAME OR INITIALS DATE OP aim COWAHY VICTORY FIRST VC EXPOSURE DATE OP DIAGNOSIS AGE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS CANADA 10 It.03.IS 1931 im SI 13 14 00,04.77 Yaa Reactor cleaner furnace up. aluteuanca, packaging Es-*auker \rd \o U ultn P <i 3 "+ ' ? L -"rf ^ 1 > DP . > - &\1 s+\\? 4 8 Si >XJ p 1 U`-i s '"TH- a\r * c(Ti ts - \i % H- < 'O' \ W 1 1 ^ t, i " c+ 1 .l_i 1 r* v-1* 9 <+ ? s\^ H* CO o to r* O ^ r! 3 *- ^c -a CMA 0 0 6 4 2 9 Sub] So.s v f,, ^0tec[; 77, irnoCo r J4^ J;,VrV: 7>; J- Vo pL,i.7rjtar 3n /,- 90-4S,, > *J f- J-' / :n ^ ' M^1 >M^. I1 'r' I'OUvt P||l 4 Oi) T r. A , CZKCHOSlOVtfU INPI1UL CHEMICAL IH0USTK1U PLC LI VCR Ai)|lourcau Cimi - (Revtaw Datu I Jin U) WX/ASl. Z - LAMCiOCASES.* I 2 1 4 36 7 a * 10 11 12 11 14 13 16 COUNTRY AMD ttmtHCI NO NAME M intuit DATE Of El RYE COMPANY PACTOEV PUST VC iirotuii DATE OP 01ACNOSE8 ACC AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OP DEATH HISTOLOGICAL COMP 1RKATEGH AST(MATEO EXPOSURE LEVEL OCCUPATION OTHER CAREER MICHLICUTS OTHER COMMENTS CZ ETHOS U>VAXIA 01 2a.Ot.2A Itat* Co Mmhy OI.07.J7 24.12.73 43 16 16 24.tl.73 Yaa Autuclava Claaaac IAKC letter of 1-4-62 giving detalla fro* Prof A David of Centra tiid Hygiene and Occ dlaeaee*. 02 06.07.27 Stata Co Hovaky 01,11.30 17.11.64 37 14 13 26.11.64 Vaa Autoclev* Cleaner 1ARC letter of I-4-R2 gave rueeuliai altered dale* fur ll*l a caee. 1 have accented tbe change* eiuce tlw detea cone froa Prof A David of the Centra of InduatrJel Hygiene and Occupattonal Dieeaaea. My date* cose originally fros HJUSH. 0V900 S p. `tos HTTa r Cal , 0r({Qr. ri s &si eu h; "' VHsi sNt- Iri cS"O'?-<, W? fUNCt to,Ui-Sj lift Bl<*t IMreKiAL CHEMICAL 1HMISTK1U ?LC LIVE# iniiourcova Caac - (kavlaw Dalai t Jw 6) Vtt/ASLJ - LANCIOCASES.MI I i 2 4 s4 2 a 4 10 It 12 13 14 IS COWTtl AMD name on PATE or nut vc OATS OF ACE AT YEARS OS YEABS OP DATE OF HISTOLOGICAL ESTIMATED OTHER 1 limENCB HO INITIALS BUT* COMPANY FACTO** SIFOSUBB DIAGNOSIS DIAGNOSIS EIPOSUBB TO DIAGNOSIS EKPOSUBE DEATH CONFIRMATION EXroSUJLE LEVEL OCCUPATIti* CAHEE* HIGHLIGHTS 14 OlHER COMMENTS KANCE 01 r H IS.04*24 or tdUM' Itloa 00.01.44 1 B.02.42 43 21 19 19.02.47 To* Hl*b Autuclava workar and claanar 19 yra Bel. Jtavler el al Arch. Hal. Prof. 1 30 it' 3 Nov 25 p 171-172 j 02 SIM 02.04.11 ecu* rl|Mvi 04.01.SO IS.01.12 43 14 12 24.01.2S lea High 2 fra on Italian Nal. OtlOSN no uiuMur origin C Aunnetua at conamQ 10 yra on al MiiuvalJtt polynar- preawe Oatlon ad leale 2 Now 1977 p 735 02 NAV 04.01.20 r St lana 00.00.44 IS.01.IS SS 20 2* 29.04.22 Too Hlftti Polyworker VCH production Ruf. Maty at 10 yra aa 14 yra al Arch. Hal. autaclava Italian POW Prof. 1 37 n' cleaner Shaphi rd. 6 June 72 Coopouadln* Sawyer, tlawou p 551-555 3 yra 04 Hot ; 22.01.22 ecu* lri|M4 1*.10.44 14.01.24 4* 24 04.01.24 Ye* m*h Houoner production worker S yra 1 eve i flItrat Ion IS yra OS 0 n.ot.ii FCUK At f|ooul 1S.OI.45 11.05.24 3i U 11 13. OS. 24 Too High Polyworfcar 1 )nor:t>toay Ref. P Coudere 1) yra 9th Feb 1924 at al 'SnBaliie coatal daw hoapltau* angloaarcowa 10 SaptooUra n 3: 2)ScfotIgraphy 1974 found ASt. Erawloualy had > 3 )Hauaorrhajiu Lona o o O' Iron ASI. 4)kight Ha pa tec tony ang1oaa rcoau Alio Mil cliuwull C 1 1 La Nituv vk 1 S1 Memo Medical HUMS*1* RotUbjGct to'p-'..- jfQSS TT /-l * L >) ' ' > r * --i":i-- ?, -"<ter 1 Cajc, ' -i 7 ' p ; , ;P;1, i s h 90 483 ? -L'-'- t f Ur*t t'OUi si- ti|i i FUNCK ShaaC 2 INfEHlAL ClIRHICftl. INDUSTRIES FLC LIVER iniloiarcoia Caiwi - (lavlaw Datei 1 Jaa 1986) Uri/AiL_2 - LANCIOCASES,! i 1 2 3 4 36 7 8 9 10 U 12 1) 14 13 COUNTRY AND KTEIINCI NO NAME 08 INITIALS DATS or AllTH COMPANY FACTORY rusT vc urosuai pate or DIAGNOSIS ACE AT PIACNOSJS YEARS OP exposure to DIAGNOSIS TSAIS OP EXPOSURE PATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTIJtS CAREER HIGHLIGHTS 16 0111 EM COMMENTS mn 06 Pa 14.04.34 PCUK 01.03.38 12.08.74 41 07 CIS 16.04*17 r SC Aiiban 01.07.30 Af etc death Ml OSH tape 00.07.76 49 ift 11 11.09.16 Yaa Moderate u 938-1960) (HIOSH 2 yra aajra iHerat liw 12.09.76) 10-11 yra polyworkar aud work* lab1 Hi la Men tied AOL prior lu AS. Ann. da Hal. Prof. July * 77 p 643 6 6. AOi wan found lu 1971 five yra before AST 16 21 01.07.76 Yea High Plane fore- 1972-6 adalu Died of (NIOSN no Man In taction In Kept 1caeula (Hilynar* SC Aukan Saall liver laacloo We Ion found alter autopay oa 1 01.04.34 Solvay Tavaua 13.03.37 03.12.73 41 19 19 10.01.77 Yaa tPilacaU 6 yea packer 4 aueoclav* clnr 14 yre autoclave worker Had Lean runnel worker previously 09 IK 08.10.14 ir Sc Poet 10.01.48 26.04.76 63 28 28 23.12.77 Yea Vary High Polyner- 10 yra In Operated 4.76 1948-1966 laacloa eulpliurlc for (eaoval o t Leaasr Ccfiaiura operator, acid factory, tuiuur froa eutocleaner, a(urUe(i[ A 1 lvec uil 1966*1976 autuclava general died after Maintenance aervlcee aecond aurglcel oparatIon tor 611 lu krone l*J al f1 at uJ a Paper ky Dr Scly cl uJ lu ArtrliWeu Jc Ma1adea Pruluealunala Vi*l 40 No 6 1979 payua 741-3. C S > 9 0 0 VW3 l C 0j\T ip t-t, JUbjeet7Tf iJ14X jj, ^a2su/n; v; "* in CaI~7r7 fo-^r Page 7 PEAMCK Sheet 3 imitlAL CHEMICAL INDUSTRIES PLC LIVER Angloaarcoae Caaea - (Review Date* 1 Jan 1906) UrXfASL_l - LAMC10CASKS,12 1 3 1 4 S6 7 4 10 11 12 1) 14 15 16 OOUH^aV AMO IKFIIINCI HO HAMS or INITIALS DAT! Of KltTH company FACTORY FUST W EXPOSURE DATE OF DIAGNOSIS AGE at DIAGNOSIS TEAKS OF EXPOSUKE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREEN HIGHLIGHTS OTHER COMMENTS 10 VP 11 L u ii u HJ 24.OS.14 ir St Font 00.12.56 10.01.71 50 21 21 10.01.70 Yet ii.01.12 ip St Font 00.01.M 12.01.ii 44 -----------yj------------- it 11.11.71 Yet i4.0(.U KMt BrtftnauA A4.Ai.4i 00.05,7S 05 It.01. Solvay Tavaiac il.ot.il ii.64.tt 46 46 --fJ-------- 21V:m" Yet li ii 12704. Yet 05-IK-2* Chine Cfefftla (Panwrly RP> St Foot iUj 00.02.II 5* 31 It.01.11 Yet High High Autoclave cleaner 10 yre In aechaulea 1 engineering Industry 1946-1966 1941-1446 polymerteatloa general purpose worker mrsm VCM eyiulieeJs (HC1 6 Acetylene) Foreaen (agent de atltrlee) 1972 retIred Died of pulnunary eabullua 5 daya after surgery Nish Honueer production and polyner- laac ion noe rator Autocleaner 2 yra, Auto- 2 yrt ta cycle Cigarette Mechanic. anoker until 10 yra ta 1974. Ill all operetur enaaeller In uf 1977 due to 9 yra, Copolyaera 4 yra aanlttry ware auufacture Oeaophageal varlcea. Surgical IntsrventIon 25.05. 79 (right leiuiUctimv) Very High 1943-1975 1975-1979 1943-1975 A11 type# of Maintenance end Jobs on work, lateraltt- Manufacture entljr 4 Maintenance 1975-1974 In VCH Poly Prwceea __________ CMA 0 0 6 4 3 3 P|l VUNCS 8h*<t 4 . n cO ' ,,0 vf f ,y< ^,_ . O`l ^0 %> '^ s^a IMPERIAL CHEMICAL. INDUSTRIES t*LC LIVER An|loiarcMa Caata * (Review Oatel I Jan 1986) UPX/ASLJI - LANCIOCASKft,! 3 1 2 3 4 56 a 9 10 11 12 13 l\ 15 it COUNTRY AMD uruuci HO NAH8 ON INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC tirosuts DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE OATS Op DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREEN HIGHLIGHTS OTHER COMMENTS Friaci 15 OEP 03.01*37 Cliloe St Foaa 07.07.55 E2 45 27 27 Allva Yea HIrIi-20 pr Autoclave CMale Moderate clearer (fontrip RP> 7 yra 1955-1962 autoclave operator 1962-1982 J C Contaeaot Letter of 5 10 1983 16 GIN 13.07.22 Chloe St Foaa 17.10.41 05.01.S3 61 41 36 03.04.S3 Yaa Hlgh-33 pra Polpserlaat- Qtlola Moderate- loo Frocaaa (Foma rip Low - 5 pra Han F> Maintenance NorEar Heal1A 4 Safety Agent Re tired Jan 1979. J C Coutaeeot Letteca of 5 10 1983 end 25 7 84. 2817 22.02.23 St Foaa 17 .06.49 03.04 B3 60 34 03.04.B3 Yaa High - Autoclave Ollier aectore Ret Ired Cblole 23 yra Cleaner of St Foaa 01.01.79 (Fo marly BF) 1946-1971 Factory 1971- J C Contaeuul 1976 Letter of 5 10 1983 21 I)It B 14.07.42 Bolvay Tavaiuc 09.09.63 21.03.64 42 2 7.12.64 21.03.64 Ulgb-12 pra AulocJei Low _ 9 pra Cleaner o 3: > 09.03.84 Night llapalectuay 05.05.8424.09.84 clieaotlu! 1 epy for lungaelaatael* : partlal realaelou. 08.64 - liver recurrence. 10.84 - lung; evoluiIon of the dleeaae tr V 9 < > 0 Stk-- t I 1HPKM1AL CllfimCil. INDOSTNIKS PLC UVKI Ai)|lo<arcoaa Ciita - (Nvlew Daut 1 Jaa Ifftt) WFX/ASL_2 - LANCIOCASES, 14 1 ** COUHTIV AND miEHCI NO 2 NAME ON INITIALS 3 DATS or IERTH 4 COMPANY SA 7 s 9 10 11 12 13 U PACTUHY ritsT vc tirosufti DATE OP 1H ACNOSIS AGS AT DIAGNOSIS YEANS OF ClPOSSES TO DIAGNOSIS YEANS OP EXPOSUNI DATE OV DEATH HISTOLOGICAL CONPUHATION ESTIMATED EXPOSUAE LEVEL occupation 13 OTHEN CAKEEg HIGHLIGHTS 16 DTI HiH COMMENTS CEIMAHV 01 00.00.30 Djr.aalt Trol*4orf 01.10.54 if.of.ta 30 12 12 25.01.69 Yaa CNIOSH) Polywo(bar 02 00.00.11 Dyaealt Troiadorf 14.10.37 23,Of. 70 39 13 U 14.12.71 Y*. (NIOSH) Folyvorker 0) 00,00.30 Dyaaalt Ehalafal- Of.04.31 oo.oi.)i 43 21 U 10.10.73 Y.. (NIOSM) Filling 4mm paatlclda Meported under non polyaer- aerosol cane )aation with VC workera In NIOSH 11t or 31.3.77. Thle of conrev la atrlcily correct. However 1 wonder whether thin wan had It lull eKpoawre to VCH in hi a CBN fllllflH operatlout M 00.00.30 Vacliar Surt~ U.M.I? lt.ll.T4 44 17 IT 23.11. 74 Y*a (NIOSH) 200-300 ppa Polyworkar 4 195S waa Clinical haMa but high temporary autoclaauer Jeialla In during 1 yr a utoc leaner for 1 yr paper hy autocleanar CoEal et al Virchow* Arch A Path 1976 372 p 193-201 CMA 0 0 6 4 3 5 9e*900 CMA 0 0 6 4 3 7 W Page U CCUUM Sheet 4 COUNTRY AND V ^ v ^ A"A A.v.Ao <*.\A v "b./A 't v.-\ A './k oA^. ' ' > NAME 0* iiiruu i^s1's> \AjVA\', O \ v' \8DATE OP Ty~t*" \y\ v. BIRTH 1HFEHIAL CnWICAL iNDVSTtlES PLC LIVER Aii|J(iurcaH Caaei ~ (Review Data: 1 Jan l$tt) M'X/ASL^ - LANCIUCASES,!7 PIIT VC EXPOSURE DATS OR DIAGNOSIS ACE AT diagnosis YEARS OP urosuu to DIAGNOSIS 10 TEARS OP EXPOSURE 11 DATE OP DEATH n HISTOLOGICAL CONFIRMATION TT ESTIMATED EXPOSURE LEVEL OCCUPATION 15 OTHER CAREER HIGHLIGHTS ~TS~ OTHER COM4 ENTS 13 04.00.U Ueldehut 00.00.60 Oft. 04.7ft 1ft 19.05.7ft IT ii (MIOSN (l... Ul. a. C... II) 1* oo.Ao.i9 Hacker fturgtuMieae 19.10.53 04.10.71 "IT 00.00.23 aan It Troledorf 10.01.55 ol.oi.Ii u..act> auapected ASL at Feh 1975 laparotoay) "sr IT Not an Aagteaarcona In Me latter of 21 12 ftl, Hr Prledel aid thla wee a Platteeapithe)kartInos Oar Speleerohre " (a carclaona of the eeeophague) aot ettributable to VCH A not recogaJaed aa an Induet** rial dlaaaaa 15 li.io.Ji T.* Autoclave cleaner and worker. Drier operator. Later ehlft leader JO oTol.TT Yea High Autoclave ASL and worker till Hepatocellular 1964. Carcfuona Loader end eter P W Beet letter uf 30th June 19tU> enc ioelng date f run Mr H P Pried*] u| SO Giicale P U Beat letter uf 30th June 19W* enduelng date I run H P Priedel ol BG Cbente wl thdrewlut Ihla raae Angloeercona c&nf I rated 09/79. Sun* detail uf thla 4 aleo ceaee 9. 13. 15, lt> A I 7 glean In NEW Report for ) 97tt Anglnaarccuea cunf|reed, tu)1 detail* uf 1(1neee elnce March 1973 given In HRW Med Inep Rep tor I97S. Dt ffereut detelle given la VC AeeucI at ed Oleuuee by 1el Lech and rat el lei Q9BI3 i>7l Crt 0 0 6 4 3 8 CMA 0 0 6 4 3 9 v to ^.f; ... - ^Mz ' -ao0 rGCil V* 7- : v; . 7.-; ; 6-X?ej. f CaJeaS(- '! '7 ^o. on page u GERMANY , Sml t Coy ^Otij siajjs IMPERIAL CHEMICAL INDUSTRIES PLC LIVES ii)|lonrctMi Ctaci ( Ky Ditti 1 Jan 1966) UPS/ASLJ1 - LAHCIOCASES.I* 1 2 34 * COUNTRY AND KPttMCK NO NAME Oft INITIALS DATE OP IIRTH COMPANY GERMAN? n HP 00,00.2? llacUl 3 PACTOftY *wK* kM*n 4/ * * 10 11 12 11 14 13 FIRST VC IIPOSUII PATE OP DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OP EKPOSUftft DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS 1*53 24.03.7* 32 24 21 29.0*.SI Yee High diaslatry - (*300 pp*> Worker 14 OTHER COMMENTS Prof CedlgfcJ etatee seteataaleed. PrieJel letter 14.04.63 24 HL 00,00.2* Heritor lurghtUND 104* M.IO.tZ 34 13 12 2*.03. S3 Yea High Autoclave (*300 Pt> Cleaner n2) E.Sch 00.00,23 Knell* r lurft- 1440 2l.09.il 21 n 14.01.S3 Y** High Polyclave bauaaa UurEer and Autoclave Claaoar Prut Edur (Munich) letter 22.OS.SJ, Prledul letter 19.04.S3 Prut Seiseir (Hun Ich) Pried el Itiiiui 19.04* *3 24 PM 00.00,22 CWU Hart m3 14.04.74 54 22 22 22.ll.B2 Y* Nigh Polyworker 17 Wt 00.00.2* BynulC Troladorf 1*33 I4.0I.S3 S3 2* IS 02.03.04 Vaa lllgh Autoclave Cleaner till 1*72 Chronic Nepal Ilia (l.elbacli). Prledel letter 14.04.S3 Lelbacli. Prledel leltei 14.04.83 VW3 rat* ti mix Op:--. p- c^4 Jo^~..-'70. ^ r*it 54;t 3/} : .,-i 'v*/ "O. Or. lata imperial chkhical inuustries pic LI VEI taftOMtcaitt Ciui * (Kevlew Date! 1 J*o 19*6) Kt-K/Ai,!- 2 - UlNGlOCASKS 1 A CtWNW AMD ttmcncf NO mil 2 NAME Ot INITIALS 3 date or IKTH A c&Mr&M s A 7 ft 9 10 n U n 34 riutT vc OATS Of ACC AT Kms or TEAAS Of DATE or kilSTOLOGICAL ESTIMATED FACTOAT tsrasiitt DIAGNOSIS DIAGNOSIS EXFOStlNt TO ESFOSUftK DEATH CUNFIftHATIGN ixrosutiK OCCUPATION QUlGMSn LEVEL 01 IU 11.06.14 FANSAC Hire 00.00.AS 11.04, 71 36 06 01 16.04,n TY (on Miaou Vftfttc* aupple- lry tfftl) ?VC Sag mruikr IS OTHEN CAAEEE HIGHL1CHTS It OTIIEN COMMENTS Friuery t mooli* nay have been pericardii**. Not tlOMOgeueuua with other caee*. ** St02 U.11.29 Hooted loon Forto 00.00.37 11.12.72 41 IS 06 27.12.72 Mergher* Poly worker a ** SJ01 VC 14.01.20 Salvijp lircrrt 00.01.53 10,07.71 22 21 10.07.71 Tea mail Atlor leaner 1972-5 did ft yra (1953- a variety uf 61) Auloclav Joke operator Includlug 12 yr* (1961 - FVe packing. m .. PI AMIC n04 20.02.37 Iahum 00.04,19 Ofl.Gl. l 41 21 30.03,ft! Y 12 yra - 1 yr - Never cleaned Vary Nigh Honoater operator autoclave*. See paper by ** S yr - CMAtnm et Hou-aaiuAer. Madlua 20 yn - *1 Med Lavoro Conauaeil Autoclave Vol 6 1962) Utile 4 yra - operator 6 pp 5S5-561 alcohol. No Low other dutlee AOL. la ftoapeue- i )oo pulpier IftfltlftA. Area Furteao tft Me Dept aloce 1973. OS C OMfttSft 39*03.3? PAMSAC Hlr* 00.00.67 07.0J.81 Venice 46 16 ft 06.04.S3 Taft Meiiua~? High lag extruder 1967-3975 Ctumetckml Dept 197639*3 S Fagilal.unga telex ot 2 Aug 196) &# MUdi M ill Lavoro iS p*4S, 19?4,, further JutaiU in letter fro* Dr ftmteeano of lAIC on April lt 1981 ft* Al*o aee Niltonl mI Sondlnelta Jo Act* OncoU|U< Vol l I960 page* 35 - 49, os2bjct to''r,' - - Pat 1 * JAPAN Ss^u 1*1 !>,:. to o*,,;. -v ^3 IMPERIAL CHEMICAL industries plc LIVE! Jlngioiircou Cam ~ (Rtvlaw Datai 1 Jan L966> UPK/ASLJt - LANG IOCASKS,21 1 22 OOtnrrDY AMD HKIUCI HO NAHE OR INITIALS DATS or UTM 4 COMPANY 14 7 a 9 10 H 12 n 14 FACTORY FIRST VC urosuu DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EEPOSUEE TO DIAGNOSIS TEARS OF EXP0SUEC DATE OR DEATH HISTOLOGICAL. CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATIUH 13 OTHER CAREER HlGULIGHTS 16 OTHER COMMENrS JAMli 01 Toaojt Jtorl 01.0*.12 HU Mil Toataw *<> (ao cffwaot by Joy PVC Aaaoc) 00.04.SI a 24.10.73 a 37 02 SO 02.OR. 39 00.II.3S 10.OS. 74 37 a 22 17 13 24.10.73 13 10.OS. 76 Yaa PVC Aaaoc . 13 yra auto aaya not clave known. cleaner * Japan 1964 - TJ aaa aaalgnad to Indicated different on 23.10.73 work aljtce expoauraa had 111 ofua at health 3000 p| up to 1974 Not known ]a polyaar* leatlon work Including autoclave daaiilag Japan Tinea 23.10.73 A Japaneaa PVC Aaaoc latter of 31.03.7* Japaneaa PVC AaaoclatIon letter of 31.03.76 * H Ma latcar of lal April IIU, Dr Haotaaiaa of UIC toy* JapanttM Hlnletry of Labour |lva Data of llagMala - ai-0i~?4 A#a of llaiMiU - 32 Yoara of oiyoeure - 22 Fas* 1I MOMMY Aoss Co- -On, ^rb.. a-Sj ia ; .' c- lo^&-fr i O/ IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Angloiurcoaa Caai - (Review Datai 1 Jm Htt) NrX/ASL_2 - LAHC[OCAiiES,2 2 1 M COUNTRY AND REFER tttCI NO 2 NAME OR INITIALS 3 DATS or BIRTH A COMPANY 3 *. 1 S 10 11 12 13 14 FACTORY FIRST VC R1FOSURR DATS or DIAGNOSIS ACE AT diagnosis YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF exposure DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION 13 OTHER CAREER 111CHLICIITS U OTHER COMMENTS NORWAY 01 AH 23.12.13 Nor eh IflTD Heroya 00.03.30 21.12.71 22 21 04.01.72 Ye* Ul*h Foreman 4 Autoclave eupervleor Confirmed by Or Tli 11 aEvanaeii of Nil. At AFttE tUg ut 9 June 19 78 Mr P Kangiiea atated that At had been a caber ot a ata*i'up (cm . VCM 4 PVC were made In #aac bulUliiK, Ttie VCM waa Bade from acetylene CMA V H r9 0 0 VWO Ul > fr? 0 0 VWD 9 * tr? 0 0 VWO CMA O' .b fm >2 USA Sheet I 1 '- o , On Ik * >' ' v -, V <?1-,'- L l A ' '-,,K), i--,C ^ \J' " 1 Cf '" 1V ~ A ;-` ",'J X-6 V^-A V9 % --......q'r1 *^ 23 ><? * MPEIUL CHEMICAL INDUSTRIES PLC LIVES AnRioaarcoaa Cate* ~ (Review Date} 1 Jan 1986) 67S 9 10 11 UK ayatea of 4aia DAK ~ MONTH ~ YEAS WPX/ASL 1 - LANCIOCASKS^? 12 13 14 L3 16 COUNTRY AND BBPSRSNCE NO NAME Ot INITIALS OATS or 1ISTU COMPANY rAcroflv rust vc SIPOSUR8 DATE OP DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE OATS OP DEATH HISTOLOGICAL CONE1HHATI0N ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS USA 01 Earl 1 2.10.23 IPG Loula- 0*.11.41 03.03.73 49 24 21 03.0). 73 Yea Parka vttla 02 19.OS*33 SPC Loota* 13.11.33 00.03.70 37 14 13 27.09.71 Yaa villa (NIOSH eeye IS. 09.71) 03 Rdvard 13.03.13 SPC Loule- IS. 11.43 n.u.n 31 IS 11 19.12.73 Yea DlavldJIe vllla 04 13.01.14 RPC Loola- 06.02.31 19.08.67 43 13 13 07.01.68 Yaa Villa 03 13.01.12 SPG UwU~ 19.06.44 09.04.64 31 20 20 09.04.64 Ya* villa 06 Ear I3.ll.Ii IPG Louie- 17.01.61 00.02.74 43 12 12 24.07.73 Yaa Awtla villa Joaeaf Put Cleaner (Slack Jeaa 1974) y 33 Ulatury given Hoi 1Ing Stuuc In Anuel a NY Art ACAD SCIENCES Ref 1 HV Acad Vo! 329 (1979) ol Sc Syap page 19U In 1974 Paper by Aleo Block R R Coll in* of Jaaa 1. 7. 74 OSIIA 9 SI Pot Claanar (Cf Block) R uf 1 Aleo Slock JAHA 1.7.74 1* si Pot Cleauer (Cl Block) Loulevllle Courier Journal 02-09-60 Pot Cleaner (Cl Slock) Re 1 1 Alao Slock Ref 1 Alao Slock Pot Cleaner (Cf Block) Ref 1 Alao Slock US Air force Pot Cleauer (Cl Slock) Ret 1 t Loulavl1 la Tlaea 23. 7. 73 Retired Ayrll 1974 Alao Slock CMA 0 0 6 4 4 8 02 Oarlaa 03.03.11 UCC 9 Oiarla- 27.06.44 00.00.6S 43 14 17 23.03.6S Yaa T Snare ecoa OS 1)6.03.10 Goodyear Niagara 07.10.46 00.09.61 41 13 13 29.06.61 Yaa Ref 1 Ref 1 CMA 0 0 6 4 4 9 C/vS \/> ^X-> HP. !sy v,,X'o' c'v- /% rt* 24 UM Sheet 3 *4 Hy & ' <** * IMPERIAL CHEMICAL INDUSTRIES rtC LIVES An|lutarcMa Cam* - (lUvlan Datat l Jan 1904) 1. 23 ** 7 8 0 10 11 UK Syate* of datea DAY - MONTH - YEAR WPXMSL_2 - LANG IOCASES, 2 9 12 11 14 15 14 COUNTRY AW iirnuct MO MAM1 OR INITIALS OAT* or BIRTN company ricmi FIRST VC PATE or ACE AT Ksrosuti DIAGNOSIS DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE or KAYO HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL occupation OTHER CAREER HIGHLIGHTS OTHER COMMENTS USA 14 Jam* Howard 04.11.27 IK Loutavilla 00.03.30 00.00.40 41 10 04 27.03.40 1*1 1951-4 VCH polyiar liatlon Froa 1054 Table 4 In onwaila In Wagoner Army and ocliar Teattaony to aarvlca. 44-30 Amy US Seuaie Confined In M N Jolmaon Ur 07.08.78 Lwlr* Yaa i) IcaraaboM 0i.01.il RPC villa 23.04.33 11.10.74 43 It 10 14.10.80 on 11.10.74 Wt AO poat-aorta* 14.10.SO I* Aarlta n.M.za tfC Artlur Avaa UM 13.00.34 00.00.75 1121 11 02.11.73 Yaa yra Navy autoc)aaar 8 yra oa Eatol Tyia Stor* plaat Ulaar 4 CarMo*t operation Or N N Joluiauu latter of 24,2.01 cmr fjiaed death 4 year* after Jlaxnoala Coutlraed In H N Johtiaon Ur 07.08.78 AJ at* Roll Ins Slone nag. 1 5.01.74 i Virgil 00.00.13 VCC S Chart*- 00.00.41 10,04.73 40 12 12 04.04.74 Yaa 2000 pp* CM*lactan ataa 0111laaaport Sun Caret la 2J June 1973 Cliarleat on Dally Mall 21.7.73 20 Jl.01.11 Cooljraar Hia|Ara 00.00.33 30.01.74 38 21 1R 30.01.74 Yaa ucc21 Cheat* r 02.09.0* S Chadr 00.11,44 laily 77 47 10 22 02.01.77 Yaa HlaUa too N10SH letter of 25.10.79 28 yru with UCC at SC Ret(red Hew* releaue 21.2.77 > 2 *9 0 0 VW3 CMA 0 0 6 4 5 1 V 9 0 0 VWO fl* 2 ? USA Mt 4 <5. , *5b ^ aC, *-rt \ O t}\0, - . , V% IHFBHIAL CHEMICAL INDUSTRIES LIMITED LIVER Angioearcoaa Case a - (Review Datet l Jan 1986) UK ayatea of datea DAK - HONTH - YEAR MPX/ASL 2 - LANCI0CASES.12 COUNTRY AND REFERENCE HO NAME Oft INITIALS HATE OR IlftTK J* ' /\ M ~^qpr "H? comma. 12 FIRST VC UPOSURE OATS OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE OATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS UR 32 C hi Clroui 2 2-02-OS HoeeanCo SprJ03field 13-10-31 ` Him 00-07-79 us 33 3 Nrguafln OS-IO-22 Jar us u Hr liria 29-0)-34 Loulevlll# 09-09-34 )1-05-32 34 Loutev)lie 1933 48 us is US 36 09-03-12 S Cherla- 23-07-44 ecoo 13-07-83 27-OS-32 The GeneraI Aehteb Tire and 111 lubber Co 11-06-33 2I-OS-S3 30 U (la FVC autoclave area) 17-Oi-SO Aa aucopay wee done end Inaedlate ceuee of death Rlvea ae `Angloaercoae Tbe death 1940-1931 certificate Varloua Jobe gave in polyaer Hr Clroui* aauufecture uauel RUTVAR occupation LUSTRE! ee Retell 1931-1964 operator Varluua |ohu In tu and 'chealcala around FVC Industry autoclevea 1964-1973 Verloue clerical Joba In PVC polyaer I eat ion facility/ Retired Oh -03- n. Lnforaat tun Riven In letter of 24 February 1962 tcM Dr Walter C Samoa of Hunaanto Springfield 11 Dr A Kuihi u| Honeunto Europe. 21 28 Multiple Jobe IncludlnR Poly Operator t Polycleaner. Prof Tauburro letter of I 2 Aug 1982 t Dr It N JuIiiimui letter of 28 Feb 1961. 21 04,08.83 Poly Operator + Autoclave Cl eeuer 1933-63. 1965 left RFC to becone a Clergy*an. Dr M H Joliuyi letter of 1 Nov 1982, 28 Feb 1961 and 9 Aug 1984. 8-07-83 HlRh Iron 1944 to 1933. Medlua fro 1933-1938 Dr Decay letter of 5 Sept 1981. 27 HodereCe 936-56 R W Lauodriu Labourer letter of 936-57 12 Sept 1961; prod helper 1957-70 patted at cJlcal perator Hay 1961. 1970-15 Teat lug leccriclan lovate need 1975-preaeiu Hay 1961 CMA 0 0 6 4 5 3 $Ub 5oa,, r*i a* USA Co--. > s i>- C?'4a3? UiraiAL CHKMICAI. INDUSTRIES LIMITS LIVER AatUMrcMi Cimi - ( Review Data: 1 Jan 1966) UK yua of ili* DAY - MONTH - YEAR UPX/ASL 2 - LAMCIOCASKS,)) ) 2 3 4 iA 1 6 9 10 11 12 13 14 15 16 COUNTRY AND UP$MIKK MO NAME OK INITIALS OATS or SltTM COMPANY FACTORY FIRST VC IXPOURI DATE or DIAGNOSIS ACE AT DIAGNOSIS YEARS Op EXPOSURE TO diagnosis TEAKS OF EXFOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREEN II1CULJCHTS OTHER COMMENTS US 1] Mr J 2* 06 2* IPG Louis- mi 06 06 64 54 31 22 06*06.64 V* High Hocked hjftoa villa regularly In PVC are*. In tha aarly day* van a reactor c leaner 1933-25. InfomatIon given In latter 09.06.64 froa Dr H H Jobnwoi US 36 Jill 16 06 22 Air Product* Calvert City 00.02.63 19.01*64 61 20 20 26.10.6) Y* Hlgli Noraal yrir 1963-1962 iraailun froa helper to aenlor operator, cleaned reactor*, trlpplug and recovery area* aa well aa charging operator. * Threw L>u cylopeula end 1eukopenle luce 19/6. Cold treatment for arthrltlw 1976. Undcl Dr* a cure about 6 mouth* before death, llad peeved tender*) pbyelcul etuar Inatlon 1 onthe eerller. J Rerr letteru of 22.10.64 1 2)/oi m. CMA 0 0 6 4 5 5 Page 30 TABLE Incidence of ASL Cases Per Annum By date of death 1955 ..................................... 1 6 ............................................................................................ 0 7 ............................. 1 8 .......................................................................... 0 9 ............................................................................. 0 I960 ................................................................................................0 1 ............................................................................................ 1 2 ............................................................................................. I 3 .................................................................................... 5:::::::::::::::::::::::::::::::::::::: 0 3.................................................................................... * 8............................................................................ 5 (Review Date - 1 Jan 1986) v 1 ................................................................................. 3 2............................................................................................ 5 A'A tA A ;................................................................................................... ;A--a 5 ................................................................................. n 6 ......................................................................... n 7 ...................................................................................9 8............................... .................... A A 9 ............................................................................................ 5 ,0^ V* 1980 ..............................................................................................10 1 ............................................................................................ 5 2 .......................................................................... 2 3 ............................................................................................ 9 4 ............................................................................................ 5 5 .......................................................................................... ^_2 O 3: Total 117 > W.B. 1 Does not Include Italian 01 but does Include German 03. O O' 2 The 1977 total Includes US case 24 which Is a Cholanglosarcoma. e.1 O' 3 The 1982 total does not include US 33 and F 15 who are alive. 4 The 1983 total does not include US 36 who is alive Page 31 Distribution of ASL Cases by Country TABU! (Review Date - 1 Jan 1986) 2 USA W Germany France UK Canada Sweden Yugoslavia Italy Czechoslovakia Japan Belgium Norway Total 35 *** 26 ** 18 *** 11 10 5 **** 4 ***** 4* 2 2 2 1 120 \'o $ \v '' \ i` ' ' ' A ' - \ . . J i\.A ^VT $> * a>- * Omit ItOl - atypical case of PVC bag extruder. ** Includes GE03 aerosol can filler. *** Includes case US 24 which was diagnosed as Cholanglosarcoma & US 33t and 36; and F 15 who are alive. **** includes one monomer worker. O ***** includes two monomer workers. X X l.e Western Europe 67 North America 45 Rest of World 8 4 S *9 0 0 Total 120 P*t8fs 3? Patt rn of ASL Cases by Factory TABLE 3 (Review Date - 1 Jan 1986) (a) W Europe Of the 67 cases In U Europe, 57 have occurred In clusters at 11 factories. Of the 26 German cases, 23 have occurred In clusters at 4 factories. ASL Cases Dynamit, Troisdorf, Germany Chloe Chimie (Formerly RP), St Fons, France BP, Barry, UK Hacker, Burghausen, Germany Kemanord, Sundsvall, Sweden PCUK, Brignoud, France CWH, Marl, Germany ICI, Hlllhouse, UK Solvay, Tavaux, France Lonza, Waldshut, Germany Solvay, Jemeppe, Belgium 11 8 8 7 5 5 3 3 3 2 2 57 \o w? K- NB: There are 32 pre 1962 PVC plants in W Europe; 18 of these have had ASL cases (Ref Table 8) (b) M America a o 'til Of the 45 cases in N America, 38 have occurred at four factories out of a total of 54 factories:- In N America 43 plants have not had ASL cases. BFG, Louisville, US BFG, Shawlnlgan, Canada UCC, S Charleston Goodyear, Niagara ASL Cases 14 10 10 4 (* c1 J Kyi * , o1 o* 38 NB: There are 28 pre 1962 PVC plants in N America; ll of these have had ASL cases (Ref Tables 9 & 10) (c) Rest of World Th 8 ASL cases are believed to be in 1 cluster of 4 and 2 clusters f 2 cases. WPX/ASL 2 - LANGIOCASES.37 CMA 0 0 6 4 5 8 Page 33 TABLE 4A (Review Date - 1 Jan 1986) Latency Periods (Years from first Exposure to Diagnosis) Country No of Cases Total Years Average W Europe Belgium 2 35 17.5 France 18 459 25.5 * Germany 26 495 19.04 * Italy 4 74 18.5 Norway 1 22 22 Sweden 5 122 24.5 H America UK 11 254 23.09 * 67 1461 21.80 ? o^ Rest of World Summary US Canada Czechoslovakia Japan Yugoslavia W Europe 35 10 45 2 2 4 8 67 886 204 1090 30 39 85 154 1461 25.31 * 20.4 * 24.22 15.0 19.5 21.2 19.2 21.80 P c.n P r ' ' s t t *i n) V S' ' ' ''J , ' 1 ' ' lu , - `1 1 J t"1 1'J \ l-' y. - -;i e h-;v V-` S 33 p c^ K1-* ^L_J* 03 U -4 CMA 0 0 6 4 N America 45 1090 24.22 Rest of World 8 120 154 2705 19.2 22.54 1ft -C a Of the countries with > jq caaea( France, UK and USA have an average latency period above world average, Germany and Canada below world average. Page 34 DISTRIBUTION OF LATENCY PERIODS TABLE 4B (Review Date - L Jan 1986) 0 9 ^ 9 0 0 VW3 * Includes G 03 aerosol can filler WPX/ASL_2 - LANGIOCASES.39 _C OITriliKNTIAL Subject to Protective Order in v. Of. .oca, Inc., llo. 90-4837 11 it Jclieirl O'strict' Court Calcasieu Parish, Louisiana Page 35 (Review date l January 1986) TABLE 4C LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE MAX POSSIBLE LATENCY PERIOD 47 46 45 44 43 39 38 34 33 29 28 24 23 19 18 14 13 YEAR OF FIRST EXPOSURE 1939 1940 1 2 3 4 5 6 8 9 1950 1 2 8 9 1960 1 2 3 4 5 6 7 8 9 1970 1 2 3 4 TOTAL LATENCY PERIOD (NO OF YEARS) ARITHMETIC MEAN OF LATENCY PERIODS 38* 37,21,37,41 32,38 38,14,32 28,11,24,20 ,24,34,39 27,22,28,29 21,29,31,26 ,28,15,23, 30,35 29,24,29,28 28,24,34 30,26,20 26,22,31,19,23,14,33 19,28,17,28 21**,15__________________ 25,22,23,22,20,31,22 21,21,25,25,21,28***, 22 22.23,24,14,19,21,27 27*** 24,28 21,12,27*** 19,17,15,13.16,28 18,18,15,17,20 16,21 13,18,21 15,16,16,16,19,19,12 13,18,17,12, 18 16,17,20,21 16,17 11,19 9,18 16 244 34.86 7 718 26.59 27 458 - 24.11 19 725 - 21.97 33 368 - 16.73 22 180 - 16.36 11 13 13 120 CASES 2706 - 22.55 120 VIOLA MALTONI GOODRICH * Cholangiosarcoma ** Aerosol can filler *** US33 and 36; and F15 still alive. WPX/ASL_2 - LANGIOCASES,40 CMA 006461 Page 36 (Review dace 1 January 1986) TABLE 4D LATENCY PERIODS OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION MAX POSSIBLE LATENCY PERIOD YEAR OF FIRST EXPOSURE LATENCY PERIODS IN WESTERN EUROPE NORTH AMERICA ROW 47 1939 38* 46 1940 45 1 37,41 21,37 44 2 32,38 43 3 38 14,32 4 28 11,24,20,24,34,39 5 27 22,28,29 6 21,29,31,33 26,28,15,23,30,35 39 7 29 24,29.28 38 8 28,34 24 9 30,26 20 1950 26,22,31 19 23,14 1 19,28 17,28 34 2 21** 15 33 3 25,22,22 23,31 22,20 4 21,21,25,25 21,28*** 22 5 22,23,24,27***24,28 14,19,21,27 6 21,12 27*** 29 7 19,17,15.13.28 16 28 8 18,18 15 17,20 9 16,21 1960 13,18,21 l 15,16,16,16,19,19 12 24 2 13,18,17.18 12 23 3 16,17,21 20 4 16 17 5 11,19 6 9,18 19 7 16 18 8 9 13 VIOLA 1970 1 2 MALTONI 3 TOTAL CASES 67 45 8 * Cholangiosarcoma ** Aerosol can filler *** US33 and 36; and F15 still alive WPX/ASL 2 - LANGIOCASES,41 r oO , AA'&I CMA 006462 TABLE 4E Page 37 (Review date 1 January 1986) PLANT START UP DATE LATENCY PERIODS OF ASL CASES IN SPECIFIC PLANTS (10 OR MORE CASES) NO OF CASES AVERAGE LATENCY PERIC LOUISVILLE USA shawinigan CANADA S CHARLESTON USA TROISDORF W GERMANY 1940? 1941? 1939? 1954 12,14,15,19,19,20,24,27,28,28,28,29,29 31 11,12,14,21,22,23,24,24,26,28 24,30,32,32,34,35,37,38,38,39 12,13,16,16,18,19,19,21,23,25,28 14 10 10 11 23.07 20.5 33.9 19.09 -----* 'ail , ift vjo-.e- v su351e ct 'lL ro!'L 'Cl T l/. ^ 5^'' a $C' + ;3i6M ^ v 'Cal0*" WPX/ASL_2 - LANGXOCASES,42 CMA 006463 Page 38 (Review date 1 January 1986) TABLE 4F LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (10 OR MORE CASES) WPX/ASLJZ - LANGIOCASES,43 CMA 006464 PLANT SUNDSVALL SWEDEN BRIGNOUD FRANCE ST FONS FRANCE BARRY UK BURGHAUSEN W GERMANY NIAGARA USA Page 39 (Review date 1 January 1986) TAELE 4G START-UP DATE LATENCY PERIOD OF ASL CASES NO OF IN SPECIFIC PLANTS(4-9 CASES) CASES AVERAGE PERIOD 1945 16,19,27,29,31 5 24.4 years 1950 11,16,18,26,30 5 20.2 1939 21,28,29,37,38,27,41,35 8 31.88 1948 9,17,18,28,31,33,18,19 8 21.62 1933 17,21,22,25,24,13,21 7 20.43 1947 15,17,21,23 4 19 SPLIT YUGOSLAVIA 1941 20,20,22,23 4 21.25 WPX/ASL_2 - LANG10CASES,44 CMa 0<>6465 Page 40 (Review date 1 January 1986) TABLE 4H LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (4-9 CASES) YEAR OF SUNDSVALL BRIGNOUD ST FONS BARRY BURGHAUSEN NIAGARA SPLIl FIRST EXPOSURE 1939 1940 SWEDEN FRANCE FRANCE UK W GERMANY USA YUGC SLAV" 1 37 2 3 38 4 5 27* 6 31 7 29 29 15,23 8 28,34 9 26,30 1950 1 2 19 31,33 28 23* 17 3 25 20 4 21 22* 5 22,24 21 6 21 7 17 8 18 20 9 16 1960 1 21 2 18 3 17 4 16 5 11 19 6 18 7r 8 9 1970 13 1 2 * Monomer workers WPX/ASL 2 - LANGIOCASES,45 < "'ag'4 C?-' -- oO '\0 .,1 , .x C.o^" '' ; CMA 006466 ft > ~ r,"- ; '' = \A-, 'i- \ - . yZ ~JQ t, ' - '1 Page 41 '/1 0t fr> TABLE 5 (Review Date - 1 Jan 1986) Annual Incidence of ASL Cases (Date of Death) by Geographical Area 1955 7 1961 2 4 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980 1 2 1983 1984 1985 TOTAL Western Europe 1 1 1 1 4 1 3 6 6 6 7 5 6 5 1 6 4 2 66* ** North America 1 1 1 1 1 5 2 1 2 1 4 2 4 3 3 2 4 0 1 3 1 43** Nest of World 1 3 1 2 l - - - 8 Annual Total 1 l 1 1 2 1 5 3 2 3 5 8 5 11 11 9 10 5 10 5 2 9 5 2 117 Cumulative Total Key Events 1 2 3 4 6 7 12 15 17 20 25 33 38 49 60 69 79 84 94 99 101 no 115 117 Viola Halton! Goodrich CMA 0 0 6 4 6 ? * Includes G03 aerosol can filler but omits It 01 bag extruder ** Does not include US33, and 36; and F 15. All still alive. WPX/ASL_2 - LANGIOCASES,46 Page 42 (Review date 1 January 1986) TABLE 6 ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING IT01) KEY EVENTS WESTERN EUROPE NORTH AMERICA 1 REST OF WORLD I ! Viola Maltoni Goodrich 1955 0 7 8 9 1960 1 2 3 4 5 6 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980 1 2 3 4 5 Total FI G1 Swl G2 Nl,Sw2,UKl.It2 G3** G4.G5.UK3 F2,F3,G6,G7,G8,It3 Bl,F4,F5,F6,F7,Sw3 F8,F9,G10,Gll,G12,Sw4 F10,F11,G9,G13,G15 G16.G17 F12,F13,UK4,UK5,G18 UK6, UK7,G19,Sw5,G20,G21 It4,F14,UK8,G22,G23 G26 UK09,It5,F17,B2,G24,G25 UK10, F16, F18, G27 UK11. UK12 66 Cl C2 US8 C3 US5 Cz2 C4,C5,US4,US7,US10 US12.US16 US11 C6.US2 C7 C8,US1,US3,US23 C9.US13 US6,US9,US18,US26 US19,US20,US22, C10,US21,US24* US27,US28 Yl.Y2.Czl Japl Jap2,Y3 Y4 US17, US29, US30, US32 US31 US35. US34, US38 US37 43*** 8 * Cholangiosarcoma ** Aerosol can filler *** Does not include US33, and 36; and FIS. All still alive. WPX/ASL 2 - LANGIOCASES,47 <v.v Jl Vo'*'5' : n V` >3 Vo 0>s v CMrt 006468 Page 43 TABLE 7 (Review date 1 January 1986 ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION (EXCLUDING IT01) KEY EVENTS WESTERN EUROPE NORTH AMERICA REST OF WORLD Viola Maiton! 1939 40 1 2 3 4 5 6 7 8 9 50 1 2 3 4 5 6 7 8 9 60 1 2 3 4 5 6 7 8 9 70 1 2 3 Frll.Frlfi Frl4 UK1 Sw2 Frl,Fr3,Sw4 Sw3 Fr9, Frl7 Frl2,Fr4 Fr7,N1,UK8,UK9 Swl,UK5 G3** G15,It3 ,G26 G7,G8,UK4,GI9 Gil,G16,G18, Frl5*** G23.G28 FR10.G1 Fr8,G4,It2,G2,UK12 Fr6,Bl Fr2,It4 G5,G13,G25 G9,G10,G12,G17,G20,G22 G6,UK6,G21,B2 Frl3, UK7,Frl8 Sw5 Fr5 .UK.11 UK3, UK10 lt5 G24 US24* C3,US27 US13, US29 C2.US19 Cl,C5,US5,US7,US28,US35 C4 ,US3,US9 C7 ,C9 ,US8 ,USU ,US2I ,US31 C6,US22,US26 US1 CJSI2 US16 Y2, Cz2 US10, US32 US4 CIO, US37 Japl.Yl US18.US33*** US2,US17,US20,US34 Y3 US36*** US23 Czl Jap2,Y4 C8 US6 US38 US30 Total 67 45 8 * Cholangioaarcona (US24) ** Aerosol can filler (G3) *** US33 and 36; and Fr 15 are still alive WPX/ASL 2 - LANGI0CASES.48 C.O-; r . -vvi - ...XK . .rV* CMA &06469 Page 44 WPX/AL_2 - LWIOCASES.49 TABLE 8 (Review date 9 January 1986) WESTERN EUROPE PVC PRODUCERS - START-UP DATES V3 ASL GASES (OMTTTPE GQ3 & It .01) STAKT-UP OOCNIKY NAME COMPANY NAME LOCATION ASL CASE (UMBER YEAR OF YEAR 1st Exposure 1931 West Germany BASF Ludwigshafen 1933 West Germany Wacker Burgbausen 04,07,11,15,23,24 25 57.54.55.53.55,69.60 1938 Italy Montecatlnl Acna 1939 France Rhone Poulenc St Fons 03,09,10,11,14, 46.48,56.41.43, 15,16,17 .. 55.41.48 1940 United Kingdom ICI Runcorn 1940 United Kingdom ICI Htllhouse 01,04,12 44.54,57 1945 Sweden Kemanord Sundsvall( Stockvik.) 01,02,03,04,05 51.45,47,46,64 Switzerland Lonza Sins 1946 France Bhone-Pailenc RoubIUoq 01 46 1947 Italy Montedison Porto Marghera 02 57 1948 United Kingdom BP Chan Barry 03,05,06.07.08.09 66.51,62,63.50.50 10.11 66.65 West Germany Ells Marl 09,10,26 61.61.53 1949 Belgiun Solvay Jemeppe 01,02 58,62 1950 France Puk Brlffioud 02,04.05.06,12 59.49.65.58.49 France Rhone-Foulenc St Auban 07 50 Holland Shell Pernis Norway Norsk Heroya 01 50 1951 Italy Montedison Brindisi 1952 Italy Montedison Ternl 1953 Austria Halvic Hallein France Solvay Tavaua 08,13,18 57.63.63 Italy Solvay Ferrara 03 53 Spain Rio Rodano Hernani United Kingdom BIP Aycliffe West Germany Hoechst Gendorf 18 55 1954 West Germany Dynamit Troisdorf 01,02,08,12,16, 56,57,54,61,55,61, 17,19,20,21.22,27 54.61.62,61,55 1955 Spain Monsanto Iberia (fcnzoo 1956 Spain Caiqsa Sablnanlgp Hispsvlc Torrelavega 1958 West Germany Solvay Rhelnberg 1960 Italy S C Ravenna Ravenna 04 59 1960 West Germany Lonza Waldshut 06,13 62.60 1962 Portugal Ores Oporto 1965 Ftmce Italy Waet Germany Rhone-Poulenc *rO--Z-Z-iL Wacker Mxttluccn Ferrariina Cologne 1966 Wart Germany Hoechst Knapaack(Frankfurt) 05* 60 1967 France AID Qilnde Balan Spain Rio Rodano Mlrmda de Ebro Greece Easo Pappas Dlavata Salonika 1968 Belgiun Badlthll Antwerp 1969 United Kingdom Vinatea Staveley Italy Runianca Cagliari Sardine 1970 Italy sm Porto Torres Sar United Kingdom Ia Runcorn 1971 Italy S C Ravenna Ravema Spain Hispavic Martorell Sweden Kamenord Steiungsund United Kingdom BP Chen Baglan Bay 1972 Finland Holland Pekems D3L Svartback Bert Limburg Cnn 0064/ I b M 1 1976 France Mazingarbe 1977 Spain Monsanto Iberia Tarragona * laboratory worker In Research Department PAM3AC, Mira Venice, case not Inducted (It 05), due nor kmdng start up date of the Plant. d rie r in 'o . SO-4 8 3 o t Court Page 45 (Review date 1 January 1986) y TABIE 9 USA PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP| COMPANY (WME LOCATION ASL CASE YEAR OF YEAR 1 1939? *ucc S Charleston NUMBER 1st EXPOSURE 07,13,19,21,24, 44,42,43,46,39, 27,28,29,31,35 41,44,42,46,44 1940? *BEG Louisville |01,02,03,04,05, 48,55,45,52,44, 106,09,16,17,22, 62,45,50,55,47, 126,33.34,37 47,54,55,53 1946? *UCC Texas City (Partially closed 1977) 1947 1948 Goodvear Firestone Niagara Falls Pottstown 08,10,11,20 12 46,51,46,55 49 Uniroyal PalnesvUle (closed 1975) 1950 Monsanto Springfield 32 51 (Closed 1975 1952 Dow BEG Midland (No VC since c 1975) Avon Lake 118 54 1953 BEG Deer Park (Formerly Diamond) 1954 General Tire Ashtabula |36 56 1956 Air Products (dosed 1984) Pensacola | Atlantic Refining Brooklyn(dosed late 1960s) Borden Leominster (Closed 1984) Conoco Hebronville (dosed 1975) BEG Niagara Great American Fitchburg 23 58 Plastics (dosed 1983) Hooker Hicksville (dosed 1980-81) Pautosoto Passiac (dosed 1984) 1957 Atlantic Tubing Cranston (dosed 1967) Tenneco Flffldngton NJ 30 59 1958 Keysor Century Saugta, Cal 1960 BEG Watson, Cal Air Products Calvert City 38 63 (closed March 1982 Re-opened Octolxr 1983) Borden Illiopolls I 1962 1963 Taneco Conoco Burlington NJ Aberdeen, Miss I Stauffer Long Beach, Cal (dosed 1982) 1965 1966 Ooooco Ethyl Georgia Gulf ** Assonet, Mass (dosed by Olin 1975, see below) Baton Rouge (dosed 1984) I Delaware City (Formerly Dianond) | General Tire/Pantas Mt Pleasant W Va (doeed 1983) 1 BEG Henry, 111 Stauffer Delaware City (Sole to Formosa 1983) 1967 Allied *** Painesville, 0 (sold to Robintech - Hooker Burlington NJ I 1968 Firestone Perryville (dosed 1982) 1969 BEG Pedrlckton NJ Goodyear Plaquaalne flHn ** Asscnet, Mass (daed 1975) (See a xwe) (Formerly Conoco) 1971 Conoco Oklahoma City WPX/ASL 2 - LANGIDCASES,50 Continued oo^7i Page 46 TABLE 9 (Continued) USA PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP YEAR 1972 1973 COMPANY NAME Nat Starch Borden Robintech *** 1974 1975 1979 1983 Atlantic Tubing/ Tallyrand Shintech Certain-teed Georgia Pacific Tenneco Firestone Formosa LOCATION Meredosia, 111 Springfield Painesville, 0 (sold to Georgia Pacific who converted to polystyrene) Cranston RI (Closeci ASL CASE NUMBER 1982) Freeport, Tex Lake Charles Plaquemine, La Pasadena, Tex Plaquemine Point Comfort, Tex YEAR OF 1st EXPOSURE * My databank, has no information on UCC before 1946 or BFG before 1950 ** Refers to same plant at Assonet ***Refer to same plant at Painesville. Allied plant never operated again for PVC after it was sold to Robintech. NB Some of the plants in this list were closed down, some have changed ownership over the years, some have changed their product. WPX/ASL 2 - LANGI0CASES.51 CMA 006472 Page 47 TABLE 10 (Review date 1 January 1986) START-UP YEAR CANADIAN PVC PRODUCERS - START-UP DATES va ASL CASES COMPANY NAME LOCATION ASL CASE NUMBER ] YEAR OF 1 1st EXPOSURE 1943 (1941?) Goodrich Shawinlgan 01,02,03,04,05 44,43,41,45,44, 06,07,08,09,10 47,46,61,46,53 1951 Monsanto La Salle (Closed 15 '75) 1957 Goodrich Welland 1966 Esso Sarnia 1979 Diamond Shamrock Alb Fort Saskatchewan ^ -C Cv> 'J 9 VC, --O' ;0' o, >o e-'ol6 OV-'.VyO^ K^: ss c,(V^ WPX/ASL 2 - LANGIOCASES,52 CM* 006473 Page 48 (Review date 1 January L986) TABLE II EASTERS BLOC PVC FACTORIES - START-UP DATES vs ASL CASES START-UP COUNTRY NAME COMPANY NAME YEAR Pre 1939 East Germany State Company 1941 Russia State Comps 1950 Yugoslavia Jugo Vinil 1951 Czechoslovakia State Comps 1955 East Germany State Comps 1956 Rumania State Comps 1957 Poland State Comps Rumania State Comps 1958 1959 1961 1963 1965 1967 1969 1970 1972 1975 1976 1977 Rumania State Comps Hungary State Comps Rumania State Comps Yugoslavia Ohis Bulgaria State Comps Poland State Comps Russia State Comps Rumania State Comps Russia State Comps Yugoslavia Vinilplastika Czechoslovakia State Comps Russia State Comps Yugoslavia Hip Rumania State Comps LOCATION Schopau Vladimir et al Split Novaky Bitterfeldt Icechim Osweicim (Dwory) Tirnaveni Turda Risnov Berente Borsod Borzesti Skopie Varna Tarnow Djerjinsk Rimnlcu Vilcea Volgograd Zadar Neratovice Kalush Area Pancevo Rimnlcu Vilcea ASL CASE NUMBER 01,02,03,04 01.02 YEAR OF 1st Exposure 53,50,54.48 57,50----------- WPX/ASL 2 - LANGI0CASES.53 . c y; '' cr: A*5 c. ,A> C * -'-..-V' A$V-' .v<3,C . yo- vo -- J ,^Z - ^ ,,$v C/a- CMA 006474 Page 49 (Review date 1 January 198t TABLE 12 JAPANESE PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP YEAR 1950 1951 1952 1951 1955 1956 1957 1960 1964 1966 1967 1968 1970 1971 1973 1974 COMPANY NAME Chisso Corp Kanegafuchi Kag Tekkosha Mitsui Toatsu Mitsubishi Mon Sumitomo Kag Denki Kagaku Nippon Zeon Toa Gosel Ryo-Nichi Nippon Zeon Nlsshin Kagaku Kureha Kasei Shinetsu Kag Denki Kagaku Kanegafuchi Kag Chisso Corp Tokuyama Seksui San Arrow Kagak Sumitomo Kag Ryo-Nichi Shinetsu Kag Chisso Corp Denki Kagaku Kanegafuchi Kag Kawasaki Yuki Mitsui Toatsu Nissan Kagaku Shinetsu Kag Tekkosha Asahl Glass Toyo Soda 1975 1977 Central Kagaku Toyo Soda Unknown LOCATION Minamata Osaka Sakata Nagoya Yokkalchi Klkumoto Shibukawa Kambara Tckushima Uozu Takoaka Takeo Nishiki Naoetsu Ohmi Takasago Chiba Tokuyama Tokuyama Chiba Mlzushima Tokuyama Mlzushima Goi (Chiba) Kashima Kawasaki Sakai Chiba Kashima Yokkalchi Hayatsukl Sakata Yokkaishl Kawasaki Yokkalchi Kashima ASL CASE NUMBER YEAR OF 1st EXPOSURE 01, 02 53, 58 WPX/ASL 2 - LANGIOCASES,54 -- & , r\. J ,vr't :i ^ A `V . c^c " y , VO* - CMA 006475 Page 50 (Review dace 1 January 1986) TABLE 13 SOUTH AND CENTRAL AMERICAN PVC PRODUCERS START-UP COMPANY NAME YEAR 1953 Monsanto Mexica 1954 Policyd 1955 Geon Do Brazil 1956 Elchlor 1960 Electrochlor Viplastic 1961 Indupa 1965 (SOC Paramanga (1967 start up PET Columbiana 1966 Carburo De Col 1967 Plasticos Omega 1968 Primex 1970 Policasa Petro Dow 1971 Polimeros Mex 1975 Rico Chemicals 1976 Petroplas 1977 Indust Resistoc 1978 HuIs Brasil Polychem Policyd 1979 PET Camacari LOCATION Lecheria (Mexico) Mexico City (Mexico) Sao Paulo (Brazil) Sao Caetano (Brazil) Capitan Bermudez(Argentina) Mendoz (Argentina) Cinco Saltos (Argentina) Paramonga (Peru) ) Cartagena (Colombia) Medellin (Colombia) Mexico Puebla (Mexico) Managua (Nicaragua) Conception (Chile) St Martin Puebla (Mexico) Guyanilla (Puerto Rico) EL Tablazo (Venezuela) Tlazcala (Mexico) Cubato (Brazil) El Salvador Coatzacoalcos (Mexico) Camacari Bahia (Brazil) ASL CASE NUMBER YEAR OF 1st EXPOSURE *0- ,, & 'c& " <*- VC, 0 v ,,S''' `w 'J ,,.?$> ,^ 1 s. <*, Q\>> \p WPX/ASL 2 - LANGIOCASES.55 \ CMA 006476 Page 51 (Review date 1 January 1986) TABLE 14 AUSTRALASIAN PVC PRODUCERS START-UP YEAR COMPANY NAME Mid 1950s ICI Australia 1960s B F Goodrich Late 1970s ICI Australia LOCATION Botany, Sydney Melbourne Laverton Melbourne ASL CASE NUMBER YEAR OF 1st EXPOSURE CA.V3 0 'I* - O'. C" ' <jQ' a?" * .,0>" WPX/ASL 2 - LANG10CASES,56 CMA OOA477