Document BR8dzJ7BpJJMj9yajKO1p6Zew

Industrial Hygiene Digest February, 1956 219 Determination of Trichloroethanol in the Urine. 1, Teisinger, V. Styblovn, and V. VUchova. Pracovni l_karstvi 7, 258-260 (l955). Bohemian. Internal and aeurological examination of 41 persona working In an atmosphere containing 0. 080-0.370 mg. trichloroethylene per liter did not reveal any dellnite relation between the amount o( excreted trichloroacetic acid and the clinical picture. Moat of the workers (33) excreted l.S to 7.5 times more trichloroethanol than trichloroacetic acid. -- Chem. Absts. 220 Neurological Examination ot Workers Handling Trichloroethylene. V. Styblovn. Pracovni Lekarstvi 7, 260-263 (1955). Bohemian. Examinations ot 118 workers (ailed to detect a direct relation between the amount of trichloroacetic acid in the urine and the degree o( health damage; however, the direct de pendence o( the neurological pciture on the length o( exposure to trichloroethylene was evident. -- Chem. Absts. 221 Biochemical Explanation of Intolerance to Alcohol in Trichloroethylene Intoxication. Z. Bardodoj, Marie Krivucova, and F. Pokorny. Pracovni I_ekarstvi 7, 263-267 (1955). Bohemian. ~ The abnormal response to ethyl alcohol in workers handling trichloroethylene, manifested by peripheral dilatation, (all at blood pressure, tachycardia, tachypnea, and dyspnea, is caused by the inhibition o( the oxidation mechanisms o( the organism by the metabolism of trichloroethylene. Its course closely resembles that o( acetylcholine re action. Persons exposed to vapors of trichloroethylene showed increased acctaidehydemia in the blood following administration of alcohol, thus revealing an analogical reaction with tha intoleration phenomenon after tetraethylthiuram disulfide. A similar picture was pro duced by alcohol in combination with chloral hydrate. It is presumed that the oxidation both of chloral hydrate and trichloroethylene, and the metabolism of trichloroethylene load ing to the formation of chloral hydrate as an intermediary product, inhibits the liver alde hyde dehydrogenase. Tetraethylthiuram disulfide increases the toxic manifestations in dogs inhaling trichloroethylene, while in rabbits the difference is hardly perceivable. The alcohol test is recommended as a means of controlling the physical fitness of workers handling tri chloroethylene. -- Chem. Absts. 222 Antidote Effects against Experimental Carbon Disulfide Poisoning. A. L. Tudeles and R. V. .Bessarabova. Farmakoi. i Toksikoi. 18, No. 3, 50-52 (1955). Russian. In mice, given carbon disulfide in sunflower-seed oil subcutaneously, LDioq ** shout 0.1 ml. Survival time rises from one to three hours when 0.008 mg. procaine is in jected 30 minutes before the carbon disulfide. When either sodium bromide (1.2 mg. ) or caffeine (0. 2 mg.) was given in advance, 2/3 of the mice survived the otherwise fatal dose. The antidote effect is evidently exerted via the cerebral cortex and may be applicable to other industrial poisons of the cortical narcotic type. -- Chem. Absts. 3 223 The Toxicity of Certain Aromatic Phosphate Esters. J. F. Treon, F. P. Cleveland, and J. Cappel. Wright Air Development Center Tech. Kept. 54-345. 69 pp. (1955). Animal experiments with seven commercial grades of tritolyl phosphate showed them to be moderately, toxic, but lass so than pure tri-o-tolyl phosphate when administered by stomach tube. The commercial tritolyl phosphates readily penetrate the skin of rabbits, canning death urban sufficient quantities are applied. All of these phosphates yielded cumu lative effects when applied in spaced multiple doses. Differences between individual grades are discussed. Xylenol phosphates are somewhat lass tome than tritolyl phosphate. The saturation of air with the vapor of commercial tritolyl phosphates at ordinary temperatures is not likely to result in ha card. Respiratory exposure to a mist or spray of these materials, on the other hand, may well be highly hazardous under suitable conditions. Toxic concentre, dona of vapor may be reached when the compounds are subjected to elevated temperatures. The compounds decompose at temperatures above 566* and the toxicity of the resultant-mix ture of the materials in the atmosphere depends largely on the extent to which the original i 15. 11 206 1371