Document BR49oJkZremo34e7VLmjeVpoJ

June 7, 1950 D r . L . E . Hamlin Medical Director, American Spake Shoe Company, 2501 Blue Island Avenue, Chicago 3, Illinois. ' Dear Hamlins . Thanks for your letter of -June 2 and for your general interest in what we are doing. Under separate cover I am sending you a series of reprints which I hope will be of some use to you, although I , suspect you have seen most of them. Actually there is no material in reprint form on, the graduate course, and there are unquestionably loose ends in the reprints, in relation to matters covered in the course. * For some time I have planned to write a monograph on lead intoxica tion, and have been gathering together a great deal of material, which, eventually, .will be used for this purpose. However, I have had many difficulties in getting to this, and I do not see my way clear even now to doing so. In fact, the completion of this job seems farther away now than it did two years ago, partly for the reason that we have embarked upon a new program of experimentation, which, I trust, will elucidate some of the points tha#*gh greatest need of cleaning up. You will remember that we studied'the metabolism of lead in a series of human subjects to whoa lead was administered by mouth. This material has been partly worked up and partly published, but is still in part in a raw state, be have now com pleted the experimental job, however, and I do not anticipate that we shall do more on this end of the problem. What we are under taking now is a study of human subjects under conditions of carefully controlled exposure to lead compounds in the atmosphere. A chamber has been built and is ready for operation:, and in the meantime I have been studying one experimental subject in a preliminary way while maintained on a normal diet of his own choosing. These observations will be continued during the entire period of the inhalation experiment, the first of which will certainly last for two years or perhaps more. A number of physiologic problems can be answered, so far as I can see, only by this laborious means, and I intend to follow through as long as I can in trying to straighten out 3ome ofUrsa matters. We are also undertaking some observations on the porphyrins, not that I think that they are likely to be either sufficiently specific or so quantitatively-precise as to give us anything like as much information as can be obtained by specific analytical means. However, I have been asked about the problem numerous times* and there are so many questions being raised at the Dr. L. E. Hamlin - (2) - June 7, 1950 \ present time, that it seems necessary to obtain some answer. W e ai undertaking a systematic study in order that we shall know whereof we speak on this matter. X shall be seeing you at the meeting of the Ramazzinians , by which time you will have had an opportunity to see the reprints 1 am sending you. If there is anything you lack at that time, which I find I can supply you, I shall be happy to do so. In any case, it will be a pleasure to see and talk with you. Sincerely yours, Robert "A. 'Kehoe, 'M. D. RAK ef Reprints under seprate cover. Safe Occupational Lead Exposure - Kehoe Exposure to Lead - Kehoe Influence of Dithiopropanol (BAL) on Human Lead Metabolism - Ryder, Cholak and Kehoe The Concentrations 'of Certain Tr ace Metals in Drinking Water - Kehoe, Cholak and Largent Lead Psbisoning Symposium The Plasma-Cell Partition of Blood Lead - Bambach, Kehoe and Logan Lead Absorption and Lead Poisoning - Kehoe Editorial Review. Manganese, Lead, Tin, Aluminum, Copper and Silver in Normal Biological Material - Kehoe, Cholak and Story . A ^pectrochemical Study of the Normal Ranges of Concentration of Certain Trace Metals in Biological Materials - Kehoe, Cholak and Story Experimental Studies on the Ingestion of Lead Compounds - Kehoe, Cholak, Hubbard, Bambach, McNary and Story Lead Absorption from Bullets Lodged in Tissues - Machle Lead Poisoning - from unusual causes - Conway Controlling Lead Exposure - Kehoe Recognition and Prevention of Lead Poisoning - Kehoe An Appraisal of the Lead Hazards Associated with the Distribution and se of Gasoline Containing Tetraethyl Lead. II. The Occupational Lead Exposure Of Filling Station Attendants and Garage Mechanics - Kehoe, Thamann and Cholak Tetraethyl Lead Intoxication and Poisoning by Related Compounds of Lead - Machle The Behavior of Lead in the Animal Organism, I I . Tetraethyl Lead - Kehoe and Thamann Tetraethyl Lead Poisoning - Kehoe