Document BMx7qBVypD2r4zmZwGk1B1wk

Nov-1a-96 05:34P Huntingdon Llfo Sclancts p.ai Huntingdon Life Im; . WJ Uox 23M, Medkn RouL T.l^une. <0) IT.l.JJJO Fm: (*0K) *T.3<WI MilUh"*. NJ OK8752.160 USA Huntingdon Life Sciences TOTAL NUMBER OF PAGES INCLUDING THIS PAGE. 5 If this transmission is unsatisfactory please contact us by telephone at (908) 873-2550 ATTENTION OF COMPANY; James B. Knaalt, PhD Occidental Chemical Corp FROM; DATE; Gary M. Hoffman. B.A., D.A.B.T. 18 Nov 1996 FAX NUMBER; 1-716-286-3141 CC; Robert A. Venezia, PhD CMA, 1-703-741-6091 Re; Vinyl Chloride 2-Gcneration Reproduction and Developmental Inhalation Study Message: UNAUDITED data follows from the trial exposures performed on 15 Nov 1996 These results show excellent agreement (.6%) between the IR (ppm added) and the GC (ppm found) results. We await your comments on the following data including an outline of the frequency of this IR vs GC companion during the balance of the trial period aml/or thejtudy period. This outline u/ill be crucial for providing a final cost estimate for the study. Please feel free to contact me or Ray Schroeder if you have any questions or comments CMA 118905 -N o v 1 8 - 9 6 0 5 : 3 4 P H u n t in g d o n L i f e S c ie n c e s dale prided: Description Study # Injected by Entered by Vertfled by 18-Nov-98 VYNILCHLORID 96-4080 Eujen Cejocaru. C? elope cor. coelf y-int 230 0.9997 26 WJ> 2 3 4 s 6 (PPn) STDCONC 5 10 50 80 100 AREA 1140 2290 11520 18766 22755 Interval Day 4 Data Injected 15 Nov 96 Date Entered /j ~ Date Verified estimated values X 5.00 1176 100.00 23026 BACKFIT % DIFFERENCE 48 9.8 50.0 81.5 988 -4 00 -2 00 0.00 1.88 -1 20 25000 , \ 20000 i 15000 * ^ 10000 ! Sample Prep Raf # Std. Prep Ref * NBR* Purity na 96-408041 1418 100 5000 0 0 Calculators % difference (std) - [pplml found ((Area y mtl/slofw) - std. ccncjlstd cone, x 100 20 40 60 60 concentration (pg/ml) 100 P .0 2 VI511-00 XLS u o p S u t^ u n n dS E IS O 9 6 ~ 8 I - a o n dale printed. IS-Nov-96 Description VYNH.CHLORID Study* 96-4000 Infected by Eugen Entered by Verified by Interval Day 4 Dale Injected IS Nov 96 Date Entered Date Verified SLf 23 28 sample to 2168. gr II 217B; gr II dilution tad 1.0 10 peak area 3133.000 3011 <rC Dom found 13.S09 12.976 XtL ppm added 130 13.0 14 Recovery 103.9 998 Sample Prep Ref * Std Prep Ref # NBR# Purity na 96-4080-01 1418 100 s e s u B io s ND = Nat Delected Calculations ppm found - (Area y int>siope % Recovery 1 ppm found /ppm added x 100 V15t1-00.XLS D U N o v -1 8 -9 6 o S :3 5 P H u n tin g d o n L ife S c ie n c e s dale printed Description Study * (elected by Entered by Verified fey IS-Nov-96 VYNILCrt-ORJO 96-4060 Eugen'Coyoauu, Interval Day 4 Date Injected 15 Nov. 96 Date Entered ff Date Verified estimated values ?/ INJ* 5 6 7 8 10 12 tppm) STPCONC 600 100.0 2000 5000 1000.0 1300.0 AREA 16766 22755 48226 110325 233476 308334 80.00 1300.00 17535 304335 BACKFIT % DIFFERENCE 852 102.2 210.6 474 9 9989 1308.9 6.50 220 530 -502 -an 068 350000 Sample Prep Ref* Std. Prep Rtf * NBR# Purity na 96-4090-01 1416 100 0.0 Catajiatums. % difference (std) [pgriml. found ((Area - y int)/slope) - std ccoc^skl cone * 100 500.0 1000 0 concentration (yrg/ml) 1500.0 VI581-01 XLS P .0 4 N o v - 1 8 -9 6 0 5 : 3 5 P H u n tin g d o n L 1-fa S c ie n c e s dale panted: 13-Nov-96 Deecription VYNJLCHLORID Study 1 Injected by Entered by Verified by 96-4060 Interval Day 4 Eugen Cojocam Date Injected 15 Nov 96 (*/6*&vu_______D__a_t_e_E__n_te__re_d /j' d'-yt' __________ _z Date Verified *t6 JsL* 24 25 29 30 *yHdaJB 316, grill 416: grIV 3176: gr HI 417B, gr IV dtotfonted 1.0 1.0 1.0 10 peak area 23618 320985 23566 264549 &<L ncm found 128.0 1371.3 1057 1216.2 5iS_ ppm added 130.0 13000 100.0 1200.0 % Recovery 96 5 10SS 105 7 101 4 Sample Prep Rel # Std. Prep Ref * NBR# Purity na 96-4080-01 1413 100 NO * Nat Detected Calcutaberia: ppm found > (Area - y in(cpt)/stope M Recovery ppm found sppm added x 100 V1511-01XLS P . OB