Document B8ez5Nqz13JeEnw3eNGwJjgJ8

tteettoa frf T re tro o p uarch 21, t#7J Attending; C. S . Thcofwon. Allan Harvey, Rcmt Secan fi, T. Vanderbilt Cw^iaoy); O r. B , K. Ashton (Jonscn Johnson); Or. William Smith (Falhoiegtet. Frrslgh Dickinson University); Fred Itiuehl, Fwter hkCarthy (international Talc Coejpeny), W. Reto U nte tsnvHle); Frd F . Raeech, Sis* S . Smith (WHITTAK5R, CLARK * &ANKLS, MC.) Duncan Ogden (Vermont Tale); Art Hrtsen (xalf); Alan Dankworth (Qagoihard lU nerais). 1 , Dr. Sfdttt opened the meeting with a discurran and elides of his expertmoma, using hampsters as a hueutn owdr to test the offset wf vaeteys mhxurat d u sts, Including tramotltic talc, supplied by VfCfD, on these r n ta tls . They war treated through the life cycle aHth v a r dosage* and analysed ter emphysema {twvjt afr tec on lung) * ftbrvste (sw * * id W Hbm;s> tissues) and tunar. Hampshire were chosen tweet o choir short lite cycle end they shewed * proper balance of seesitlvilyi Snsenritlvtiy to lung Irrtente so as to provide good screening. Fifty ankeal* were used I each ex perim ent. The attached tables shew details a t number of tumors M*wtfMioa| from various causes, h was found that a cwrbination of Irrtente (total environment) is mors s ilv t, causing cancer at lover levels than required by either term. T hus, small do* af cigarette amok and soft chryotilo toge&ar ipiu be carcingeno due te the Irritating effect of cferys^sU causiitg a douyed eleerance of rt&kt from thy lungs. Short fibers caused ter.a tuir-if growth then* long, svh though fibers wore lying directly on the surface of the lu n f. Crocldellte. usec4 te Tobfc 2 , was the most active. Table 3 icKflcettet that thicker spun glass fibers *rc Hess active than thin Silica fitters even though, tesorotieolly, they have the. seme chemical cocfpuslliorr. PLAINTIFFS EXHIBIT W C D -327 WCD000178 WCD000179 I t e l Kfeissn iMMiytocMMf M FQA CMM^C fpeup fM HI$SH fcave Oartss a cr*ah stttty f an kind *i a #jhiwaciiui/;co piani in Arizona. Ko d&ofte we? ^vaUabie at th* w m sn t. WCD000180 DOSE S* t TASU TUMORS fo tm o ttTW VARIOUS ousts CRRYSOTL AMQSTE AHTaOWTtLTE C R saoD im -- *-- -- --------------- ft t s i t g <% TABLE 2 6 WP6CT o f fiber LBtGTH AVERAGE USNCTH . W-H*tnwtrtfcfrfrJg j# l ft,f W ien# S,,j Mlfiretws & $ Miera** #,,ft f^eroRt edtfBSF CROCmOUTE Sfft tt9i**fi sert Harsh uM seft WfrOf.FwiT^i|mUi*MriO#i|iR|iii^SwfciPM^tta ft ' ft e WCD000181 TAtB * J- EFFECT OF FR CO#FO$m*i t A U m A L Tnasomic Tate S*np.tk Kock >u*t Ccfeemicftliy ffk* but net fibrati}j i Wwwitte (Fttoret Magnesium Qiccte) DM*KOMSfe*EW> 2S mg w$ $ & ag Stiles Aber Cftu Flfesr Clww F8a*r* with phenolic bind 1# T1*'*U tH -m i 0 1 % $ & WCD000182