Document B8dY7ZBdXkO29kZGxnEeb8Jao

INDUSTRIAL HYGIENS FOUNDATION OF AMERICA.INC. M<l^on Institute, 4400 Fifth Avf.nuc PlTTCSUftOM, Pa. 1S3!3 April 13, l$3$ Csrtain*laed Products Corporation Jchrie Maaville Cc rporaticn Owens*Cornin riharglas Corporation Fitteburgh Plate Cla*e Corr;fiay U. 5* Rubber Company Attached ifi 4a Industrie! Hygiene Foundation aebcetcs tar. fibre* lara three-year reseatch projtct proposal inccrporaciag suggestions made by those lined vho attended 4 research planning meeting in my office ca April 12, l$ ja. Alec enclosed te r contractual agreement in an ori-:nal sari cne copy, in the event thot rpeneerrhip of this project is improved, beth should be eirned, the carbon returned end the original retained for the sponsor's Robert?. P. deTreville, 1.D. Director deT:s;c Enclosures cc: Mr. 'Marshall Burch, Owens-Cornin? Fiberglas Corporation Dr. G. S. Bishop, Owae-Cornin$ Fiberglas Corporation am ***outtor or M0o*rmc roe tmc AevAACtwcer or *cAirrta oohoirtom* . luowsYAUi MVOiiKia rcunG+non or amcrica,inc. fesitttso IwaviYunx, 4$C{* Firr*/**u* * * P;y?aau*o>Kt Pa. iei* Aj*tt Ilf Mb. 5*a*5>o*fc&J /* A& Xa**8t*.$:Uiea - ft* ?ht tpoeifUUy cti A*b**94 aai *a b. Sialo^U tf*cut 4i S*ac dcs-auasos A*J4a4A tt3b C4?y8<S'vU A*feOi'dO. preaonucrio^ V* ^bacaoci* * * fcaad &&t afcou* $Cf= of tio pafr?U that bad la Is Cap*;^w* {l d ecftsccvrtra caiepoloe) bad Cl4jb*cl*5 bodUe* la. iij ?t*w3 6*4230 aitibsr* v foood * Insist proraJaaeo of "asbottco 'tcdUelt &taofc t?* &&&a ta JUs^i. rjfiriia. Cfitiss, Cottwi sd Geo*! >; tU 2aa$e fi4ao#*ios^a aoifpUai de-&3 fo? tfei. tft&*w * ^ornito^i^k bad Was eVftaiaod# ,ft^i itaaad tUt dC# o? thaso Uf badUa;* la te3S Its ?4sstiy roportod a 4?> S rova^co ia J&ti3oobtt?3 * ^js # aft prusil* a ?iu*^iVU doubt tbaft "rebittoi fcodioo* ir cp4ciri4.tadt*U73 tf tbo taluitttftz d aofcootoo &ora, fiveh bcdloo hftv* boon >Ud is &ai mbtri isf ulc vst!a? Ur ftboy btvo U& cftilfd *`pff**6caw*6U3 b^iifN Slactatty Darlo1^ aad Colloft*^) hbv docaooetirotod # cbo btractUuUr d*vXepGoaC oi "A&bosrfoo lodlca" oooe&dary to emoopbau* iosl4?i4i ju. *r*f raftfJAna* or AUiwoe.iwa l. JUI-4zUjz occoplee m caomaloue poeltioa la Us ability to produce luag d&aa&3* ciurotaj diJtfuea flbsosle ac well as the production ti lung ceacer* It Ic ufitxtioui t so oiiher fUUet* hot bt charm to possess thle Uilits T:s flbrioie eacsvaured la lilctsii la limited to the tremoUte variety, wai.th U tvb*mxei&*'# Cs the other head, too p&iutaeccfUccia teeoeUUd wish ijr* rtf s5ri silicate) has act sees lave*? lotted espo?lf*.&Uy0 ..! th* ilbregecic activity at tii ducts ceasictlay vaHLtSo the mice has aot fceea dar wUlectac may ov<&3 either or rslativcly alight IsiV-^A&wry ufcor.yes* dad certainly ora laeepeble c2 producing lung cancer. Irasraush c-c certain yxlysyzliz hydrocarticao aac trace tcetaia fcccwa tu. he r.ciesu c;oato bv boon decioanrattd la e&bcetocj y artlcviorir niche! end bcns&syro&a* tLe possibility e&icts that the trace cnAVl */sd/er the polycyclic hydrocarbon .aay ho eaiely responsible *ar she / niacwiu yc&escnUUy. *2hit To^olwlUty Id sup^sr&td by tire /Isdlayss i,.- JLi r>*crt *4 firaus cad Xresaa'^ which Indicated that the prove* J.sace ru; lua-s *** catoag Canadian asbestos c&lnerc v4 nc greater than 1U5 si general population.* This vac Is cootract to the report oi *!?hlct:: Indicated a Increased rich o ltaf caacer nwetj SritUh worhe ro exceed to esbeetoe duct while /afcrlcastag the aabssSos. 2. Ir. a scs&st Investigation la the laboratory ei the la&etrlal Hygiene Foundation. Itajt caacero wore louc4 Id rate espoaed lor lftmenthe to high efface?/;; atlosis of chrysolite duct* W ac*uso rate eupoaad to chryeotUe duet fey occrr investigator# failed to develop luog concert there to a good probability INCUvTftIA;. HYwlfrt rCMHOATK * Of AK*.'CA,IMO J. that th* cLvycotlle dual tbit produced luay ctacar tret elynllic tally dl/*?ct iron tbt vrMch 614 heve &u XI U Ulbily the! (Ue d^irtaec & ctucai by e oe&'.tstj c eisks! *j#al dlcy implied Co the esbaetee duel yersiclae dayIs2 tit lv.ir.at? rr.lliU.j jyyocot* uno ear vendcriay tht dul stspirfbl*. 7i.io CA**ilid b?.e re* feytan um4 by 3*TOwt0 lroot!f.?>lero* Kiehai bj It c* 2vsf cracer ts trees nsfiowa**. Al&ouyh tvlMi:c ead gKe* fare bote iUiau>, thr b^wtriil ksdu tt7itae triH vorhara ci Qiet tvt nu?Ui? tee baeu restiy d'iiare&t* ?\o pulraoctry dlt;tti k&t baeia reported U worker* eswteed b*> fleet duel* l?tv.rj!k>t, tie dost T tUteantaea fltae bee bora laialrd at L`sllf dee; arce* la tk u/ prarr by i.iKicitot with aebreua. II U a led tfca ulia^v-1* Ho t.'.-Vsi c2 /lci-a ?iis ; civt a tu lust,** ri ea&jeele bet boas retread, u> elcr.'J.t'* bat. btra tisJ- of tie duct si flhoeifrtcna friesc without es / vclr.ted rsr!;& er til*?, . Fbeat 1* XI Is pnss4 te area.lee the res^caee d atisali irtft .tr d!srs&t - * Iwr'tak il?vc i&iuriale ci eontraetitj eheaicd ematoiUieti ul to ehcr&citrUe He distress*t u4 alrulSt/Uleo la He ettpca*a Photo?. Xl it pva^aeii to Savtetljtu the idlseaea ri trace nUertle tad p*ly ^ cyclic byirocerbaet (!* butepyreae) cos related with efbttto* ora or Iba ethaequeal practiaki; at the Uae*tsra retpeeate oi the lu&g to the dost. WOOStSlAV HYStCMC VOUHOAYOM Of AMC*tGA,N0> d. Another objective of Jfai* phase (a to obtain definitive dtU ca the long* Una nffict of duet derived from ftlemcetous (Ur- 'tpoi tht lvaf} 7b;i ' verHi'.sa of such glass dust will bs investigated* . .. * . 1. v/llb the pb*?toifcrme!dchydc*typ of binder 2, with the bidder ur-so In textile* 2* vit&out binder* MAT3R7A13 ant* MSTKSIP Fbnte 1# Ths following fibrous materials will bo reduced to respirable particle tin (O^rJ end will Ve Infected la amounts of 3*9 tsf. to 30 mg* as aqueous suspcaeicaet 1. cbryeotUe dust (prepared by nlUl*| la Wright mill aad with demon* stre.ted carcinogenic potential) 2* chryroiti* dvit (untnUled synthetic)* .. , . 3t, aliTninum nitride *d. trioeleiuvn phosphate (iUamtateuo) / 5 fibrous glass a, * with pbeaoi*formaideVrde*tyw* hinder , b# with binder used for tsi&lee ** e* without binder 6, etfctrim hydroxide (brucite) 7* mineral tsool & tine otddt (fUamcatous) s These materials will to ixjected lotratraoheally into tamesors tsdsr t:<Iur aces thesis* Previous experience las doraoratrated that asbestos bodies will form la. response to ohrysotUe dust within ttvs tmeaths* The animals will therefore be held for six months and then killed* The lungs ulU be sapendsd with buffered formalin under a hand of v 19 cm* cf water* Slocks removed from these lungs will bo soctUaed at iA f veiholln chr/scCilt has been prepared at Mellon Institute by Or* VfUlitta CfatauttL lc.elrcm nhofomiereftreoae snow the oharactetieiU twbtu&r crystals IMCUTftlAW KYOICMC Of A^CAIO%.|MO. 5* slier per&lfia tmyrejnatioa. The*e eeetlone mill be mined by different tneihoit 4i.i photogrt-pned eee^enti&lly to provide meet* lor studying more th dittt* reaction to thi vericu* Sir^ch lor the o-c*lltd bodies rill U m^a ueiag routinely bUiatd ceetione, ectUr.* et/isc lor ires. In a&t*isad`6<e*s,*d sectlea* will be r-ii-.iti v;.vj*r *it.r}>ficla sc&dlU*;&0 lor AsUxtte lycdUs. 7i latter glow .when ta. thU tuaa&er* 7c s dill* rear.* la tieav.e reaction tet-rseu a-"sciatic chrycotUe cuet aid t.vtl w;ii-sr. to h:^ to fee fifcrcgesic -rell i* coreiargonlc will *;oiot ;o tJ.s. e.catyihusici to pvihifeaieliy ta*A:# Vy a &/ mcvii ef the verieu* trs.ee subm;:.**.: vi.Sch racy be acrccleted with e&ryectil aeheotoe duet os A Th* iev*lcrre:i 05 "t-trefto* bodl*eM, better testr-ed xorrltia bodies .(Wo!laU) tv ducts o^hes then t*i*?toe vovld point to Ch* aon*ft?*etfisity cl . ihc * ir:;'i*;?5i tti to the rUt^t^UUy cf coUef.ttrr such bodieir" Ircm iv.rr.st tr ordor to lubjttt them to tiittraa-otobs m&lyti*. Such caaiysia e&uIJ. jiv lufortnetita is rejerb to tU vlixicsl raakt*up of the fl'Af t roijcaijibi* lor the development cl the (ertitb ("tsbeetoe"} W.y. * ?h*ee 2, In order to explore the etioJoyic role ol the verioue comroaeaU t ehryeotlle eabeetee la the prolnetloo of long llbroeie aad loaf ceacer* cU eeriee 1it rets will be Injected btratrtsbciUy with the followings * 1* ehryeotlle duet festovo* to bo carcinogenic 2, synthetic ehryeotlle IfcOUiTAlAk MYOICNC SOUNOATICN Of AMCAtCA.INO. 6* 3. synthetic chryaotile plus nickel 4. aynUietic chryaotile plus nickel, plus hensopyrene 5. nickel alone or with carbon aa carrier 6* benacpyrene with carbon aa carrier* .These rata will be held for two years and then killed* The lunge will be prepared for examination and sections cut in the same manner as in Phase 1 Three other series ol rats will be injected Intratracheally with the following duets: 1* filamentous glass with phsnol-formaldehyde-typc binder 2, filamentous glass with the binder used for textiles 3 filamentous glass without binder* These animals will alco be held for two years and then killed* The lungs ' will be prepared and studies as in the preceding groups* The number of animals per series will be such that there will be no doubt regarding the statistical significance of the rssaltr* / .PROGRESS REPORTS A progress report giving the results of Phase 1 will be submitted at the end of 12 months* v Aa Interim report n Phase 2 will bo submitted at the sad of 24 * months* and a final report will be submitted at the end of the third year* COST The cost of this investigation is $10,0C0 per year for three years* or $30* 000 for oach of the five participating companies* * K'QUfcTMfAfe Of A2M4A,mO. supervision Research vUt be performed under the direct supervision of Z)r. Ptul Gmf plrtetor of the ?o\u>dt(eB' Itestarch Laboratory* The Found* tixi's rtndie* os. ssbsstoo presently aro being conducted under partial support of the U.S. Government through a National Institutes e Health great tnd e eoatract with the U.S, Public Keelth Service, Division Occupational Health (Dr* LowU J, Cralley)* A list of Dr* Cress' publications la the pathology of pulmonary diseases, and a membership information booklet describing laboratory projects presently in progress, are attached* 6 t / m~u*vi,+niAi wT#tc*crouHO*noY or A*noA,t'*o. < attest rasa ! i, Thomaoa* X, G., Kaict'UA* It. O* C. ai^ ^c^OAAld, R. R. AiUitoi ti Modtra UrVan lksArd* S. Afr Mod, J. 3s?59 1962* * 2* Thomson, J. G* A*bo*too is4 tho Urbta JCHroUor in 2Molo*ie Sifoott e< Atbaetoa* Amnia of How York Aeadtsay of cltvce 1-r.UVS* K4J. 1 .> Caurj, D., Tctica* R. 2* and Groot, S\ AsVoatoa Bodice in Human Lung* 4t Autopsy* JA#2JLA* 193 4. Wobattr, i. *nd Ch&t^dakla* 'Uncictnco cf Aabostos Sxporuro* n* 24*25 Annual Report on MoCicnl fitiAixb 196219&4* C3SI Rot>ort, Pretoria, S. Africa, 19$* 5* Daria, J. M. 0, Electron Mieroacordc Studio* of Aaboototia in Maa id Animal* is Biologic D!ocio of Aabovtua* Ar-r.aia of Iow York Ac***fiy 04 Scieaci* JLii*** 1905, d* Collot, A.. Force**! comnjiic*tia to Dr* Cro*a, 1964* ,. ?. Srovn, D. C* cad Truaa, T. D* * Evidnalologica! Sirady of Long Cancer In Acaoata* Miner*, Arch* iadcci* jKoelih ,17:$3<, i'/SS* / , A r. n.vll, r., Mortality from L/sng Career in A*bo*lo*\7orhorf. Szifc. . ^ Xu.hiis, Mod* 1955. ? . *' 9* Croi, P* iMdATroriUti R7*&t ilW^UeM i* . , -L *, *. * f \