Document B83YnkD2odaGgbB0q0qMra96J

BIO-MEDICAL.RESEARCH DOCUMENT DESCRIPTION FORM 63 Duplicate In all cards:--> 68 69 76 | 00003IS year as-1961- File number [Right justify (Numeric only] Author(s), as Last Name FS (No Punctuation) and coden for journal as JAMA preceeded by one blank space 1 LjrA.lfS/rt. , M 20 21 WC/d/rit, 4- 40 41 77 78 Sub-Index Code 60 61 62 11 12 13 Title of Report; end with space-hyphen-hyphen-space. Follow with Index Terms, separated from each other with comma-space. Avoid other punctuation; do not abbreviate. 12 61 62 R&S 111202 Source (Journal, Vol., Number, Pages, Date) 12 sL Brief Summary 12 10 SUMMARY: 61 62 31 32 61 62 61 62 63 64 Toxicology. 11 (1978) 45--54 Elsevier/North-Holland Scientific Publishers Ltd. 000316 EFFECTS OF VINYL CHLORIDE EXPOSURE ALONE AND IN COMBINATION WITH TRYPAN BLUE - APPLIED SYSTEMATICALLY DURING ALL THIRDS OF PREGNANCY ON THE FETUSES OF CFY RATS GY. UNGVARY, ARANKA HUDAK, ERZSEBET TATRAI, M. LORINCZ and G. FOLLY Departments of Experimental Pathology and Chemistry, State Institute of Occupational Health, Budapest, H-1450 Budapest P.O.B. 22 and Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, H-1450 Budapest P.OJB. 67 (Hungary) (Received December 29th, 1977) (Revision received May 22nd, 1978) (Accepted May 23rd, 1978) SUMMARY Vinyl chloride (VC) has been shown to be present in the fetal and maternal blood as well as in the amniotic fluid after the exposition of pregnant CFY rats to VC at an atmospheric concentration of 5500, 18 000 or 33 000 mg/m3 (--2000, 7000 or 12 000 ppm) for 2.5 h on the 18th day of preg nancy, indicating the permeability of the placenta to the agent. Teratological investigation of the offspring of pregnant rats exposed continuously to VC at an atmospheric concentration of 4000 mg/m3 air (1500 ppm) during the first, second or last third of pregnancy has shown that VC has no teratological effect in the rat and has no embiyotoxic effects either, when applied during the second or last third of pregnancy in the above concentration. Exposition to VC during the first third of pregnancy resulted in an increased fetal mortality and in the manifestation of embryotoxic effects. Fetal losses and induction of central nervous system malforma tion due to trypan blue administration were not potentiated by a combined exposure of pregnant rats to VC and the dye. INTRODUCTION VC is ranking 23rd from among the 50 most widely used industrial chemi- Supportd, in part, by th Scientific Research Council, Ministry of Health, Hungary. 6-11-0401-03-1/MU. Abbreviation: VC, vinyl chloride. 45 ."uw.r V