Document B81KpxR0Ldw160akaygNBJg4E

3M General Offices June 6, 2005 3M Center Si. Paul, MN 55144-1000 651 733 1110 p .i M n 6 _ 31H-Z Ms Rose Allison U S Environmental Protection Agency EPA Last Building 1201 Constitution Avenue, N W Washington, DC 20004 Subject: Peiiluorobutane sulfonate study reports associated with PMN submissions to the US EPA (P-00-1085, P-01-584, P-02-16, P-02-195, P-02-609, P-02-700, P-02-88.3, P-02-891, P-02-920, P-03-32, P-03-77, P-04-174, P-04-176, P-04-537) Dear Ms. Allison: This communication contains three compact disks (CD) that incorporate recent updates to perfluorobutane sulfonate (PFBS) study reports. This CD is supercedes previous versions The reason Tot re-issue of the CD at this time is the addition of two reports that arc new since the last version that the EPA received The first addition is the avian reproductive toxicity (OPPIS 850.2300 / OECD 206) and it is listed as entry # 26B The second addition is a letter discussing a histopathology review of select tissues related to the 90-dav oral toxicity (OPPTS 870 3100 / OECD 408) and it is listed as entry # 9A. On the enclosed CD. you will find: A copy of this covet letter An index to perfluorobutane sulfonate study reports on physical chemical properties, environmental and mammalian testing with the following organization: Mammalian toxicity testing Bcotoxicity and fate studies Avian toxicity testing Physico-chemical properties, fate testing and supporting analytical methodology A discussion paper summarizing the results from the testing conducted to date by 3M on perfluorobutane sulfonate The four folders contain sanitized copies of the study lepoits submitted to the EPA to date as listed in the index 3M will continue to provide information on a regular basis as it becomes available The CD is for read-only put poses and is not to be modified 3M will maintain a paper copy and the original CD copy of the documents The paper copies will control over the CD in the event of any discrepancy Please feel fi ee to contact me with any questions Regards, Jay F. Schulz Regulatory Affairs Specialist Specialty Materials Regulatory Affairs 3M Center Bldg 236-1B-10 St. Paul, MN 55144-1000 P-2 3M Mammalian Toxicity Testing 1. O E C D 4 2 3 -O P P T S 870.1100, Acute oral toxicity (rat), 132-002 2. O E C D 4 0 2 -O P P T S 870.1200, Acute deimal toxicity (rat), 132-010 3. O E C D 4 0 4 -O P P T S 870.2500, Acute deimal irritation (rabbit), 132-004 4. O E C D 4 0 5 -O P P T S 870.2400, Acute eye irritation (rabbit), 132-005 5. O E C D 4 0 6 -O P P T S 870.2600, Skin sensitization (guinea pig), 132-015 6. O E C D 4 7 1 -O P P T S 870.5100, Bacterial reverse mutation test (Am es test), 0623-2140 7. O E C D 4 7 3 -O P P T S 870.5375, In Vitro Mammalian chromosome aberration (CH O cells), 0623,3110 8. O E C D 407, Repeat dose oral toxicity (with F O B & histopathology), 132-007 8A. O E C D 407, Repeated dose oral toxicity (Range Finding study), 132-006 9. O E C D 4 0 8 -O P P T S 870.3100, 90-day oral toxicity (rodent), 418-026 9A. , Histopathology review of select tissues, 418-026 10. O E C D 4 1 4 -O P P T S 870.3700, Prenatal development toxicity (teratology), 418-023 10A. O E C D 4 1 4 -O P P T S 870.3700, Prenatal development toxicity (teratology)-Pilot Study, 418-023A 11. , Pharmacokinetic study in the Cynomolgus Monkey, T-7485.1 12. O E C D 41 6 -O P P T S 870.3800, Reproduction and fertility effects (Two generation reproduction toxicity), 418-021 Ecotoxicitv and fate studies 13. O E C D 2 01-O P PT S 850.5400, Algal toxicity-94-Hour toxicity test with the freshwater alga, 454A-129 14. O E C D 2 02-O P PT S 850.1010, 48-hour static acute toxicity test with the Cladoceran (daphnia magna), 454A-118A 15. O E C D 211 -O P P T S 850.1350, Chronic toxicity test (daphnia magna), 454A-130 16. O E C D 203-O P PT S 850.1075, 96-Hour static acute toxicity test with the (bluegill), 454A-114 17. O E C D 203-O P PT S 850.1075, 96-Hour static acute toxicity test with the (fathead minnow), 454A-115 18. O E C D 3 05-O P PT S 850.1730, Fish bioconcentration (bluegill) 19. O P P T S 850.1035, 96 hour Static acute toxicity with (saltwater mysid), 454A-128 20. O E C D 106-O PPT S 835.1220, Adsorption / Desorption, 023-048 21. O P P T S 835.1110, Activated sludge sorption isotheim (incorporated with O E C D 106) 22. O E C D 2 09-O P PT S 850.6800, Modified activated sludge respiration inhibition test, 454E-102A Avian Toxicity Testing 23. O E C D 2 05-O P PT S 850.2200, Acute avian toxicity (Northern Bobwhite), 454-112 24. O E C D 2 05-O P PT S 850.2200, Acute avian toxicity (Mallard), 454-113 25. O E C D 205-O P PT S 850.2200, Analysis of fluorochemicals in Bobwhite quail samples, E02-0659 (from study 454-112) 26. O E C D 20 6 -O P P T S 850.2300, Pilot chronic avian toxicity (Northern Bobwhite) 454-115 26A. O E C D 2 0 6 -O P P T S 850.2300, Pilot chronic avian toxicity (Northern Bobwhite) and Test Protocol, 454-115. 26B. O E C D 20 6 -O P P T S 850.2300, Final Avian reproductive toxicity (Northern Bobwhite) 454-116 Physico-chemical properties, fate testing, analytical methodology 27. O E C D 105-O PPT S 830.7840, solubility studies (water methanol, acetone), #FA C T -T C R 009 28. O E C D 1 05-O P PT S 830.7840, water solubility in nanopure water, 454 C -1 18 29. O E C D 104-O PPTS 830.7950, vapor pressure by spinning rotor gauge, 454C-127 30. , Laboratory incineration study of P F B S and fluorochemical polymers, U DR-TR-2002-000153 31. T G A in air and helium (Decomp. Onset: 505C (He), 522C (Air) and D S C 32. Differential Scanning Calorimetry (D S C ) Melting point (273C) 33. Boiling point (acid form) (200C at 101 kPa) 34. Discussion of the photolytic decomposition of P F B S 35. Discussion of the hydrolysis of P F B S 36. Discussion of the determination of Air-Water partition coefficient of P F B S from vapor pressure and water solubility 37. Analytical method validation for determination of P F B S -K in fish tissues, 454C -116 38. Analytical method validation for determination of P F B S -K in freshwater, 4 5 4 0 1 1 5 39. Analytical method validation for determination of P F B S -K in saltwater and algal media, 4 5 4 C -1 17 40. Hammett Acidity Function, Literature value (H0 = 13.2) 6/5/05