Document B5e1kDZMZ20bY0n6wLpxvp1No

RECEIVED AUG 2 j 'oo CHEMICAL MANUFACTURERS ASSOCIATIQMi^g^g- Augus t 15, 1986 Copy: Dear Vinyl Chloride Panel Member: X-,'. --------------------- Enclosed is the draft report "Epidemiologic Study of Vinyl Chloride Workers." At this time I am trying to schedule a meeting with EHA for the first part of September to discuss the results and the report. I will let you know the date and time, and where the meeting will be held, as soon as I have the information. Please review the draft report. I would appreciate receiving your comments on this by the end of August so that we are prepared to discuss it at the September meeting. Sincerely, Has Shah, Ph.D. Manager Vinyl Chloride Program Enclosure VVV 000002429 Formerly Manufacturing Chemists Association--Serving the Chemical Industry Since 1872. 2501 M Street, NW Washington, DC 20037 Telephone 202/887-1100 Telex 89617 (CMA WSH) Environmental Health Associates, Inc. August 7, 1986 Hasraukh C. Shah, Ph.D . Program Manager Biomedical and Environmental Special Programs Chemical Manufacturers Association 2501 M Street, NW Washington, D.C. 20037 Dear Has: Enclosed please find the draft report "Epidemiologic study Vinyl Chloride Workers". After the Task Force has a chance to review the report, we can schedule a meeting in our office in Oakland to discuss the results and the report. of I am also sending you the last invoice of the project. It has been a pleasure working with you and the Task Force on this proj ect. Sincerely yours. Enclosure OW/krac Otto Wong, Sc.D. Senior Epidemiologist VVV 000002430 520 Third Street Suite 208 Oakland CA 94607 (415) 451-1888 Draft Epidemiologic Study of Vinyl Chloride Workers Prepared for Chemical Manufacturers Environmental Health Associates, 520 Third Street, Suite 208 Oakland, CA 94607 Inc. August 5, 19 8 6 VVV 000002431 Project Staff Otto Wong, Sc.D. M. Donald Whorton, M.D. David Ragland, Ph.D. Carolyn Klassen, B.A. Debra Samuels, B.A. Kathleen Claxton, B.S, Principal Investigator Co - Inve stigator Research Analyst Research Analyst Research Associate VVV 000002^32 Table of Contents Summary Introduction Materials and Methods Original Study Study Update Results Descriptive Statistics Cause-specific Mortality Analysis Entire Cohort Analysis by Length of Exposure Analysis by Latency Analysis by Age at First Exposure Analysis by Calendar Year of First Analysis by Type of Plant Exposure DISCUSSION CONCLUSION References Tables Page i 1 4 4 7 13 13 15 15 17 19 20 22 23 25 35 36 37-55 VVV 000002433 List of Tables Table 1. Distribution of Vinyl Chloride Plants Studied by Product and Number of Workers 2. Distribution of Vinyl Chloride Plants and Vinyl Chloride Workers by Geographic Regions 3. Distribution by Vital Status as of 12/31/72 in Original Study 4. Distribution by Year of Birth of Cohort Members 5. Distribution of Year of Hire of Cohort Members 6. Distribution of Age at Hire of Cohort Members 7. Length of Employment as of 12/31/1982 of Cohort Members 8. Distribution of Vital Status of Cohort Members 9. Distribution of Year of Death of Cohort Members 10. Distribution of Age at Death of Cohort Members 11. Observed and Expected Deaths by Cause SMRs and Their 95% Confidence Limits for all Cohort Members 12. Observed Deaths by Cause and SMRs for all Cohort Members by Length of Vinyl Chloride Exposure 13. Observed Deaths by Cause and SMRs for all Cohort Members by Latency Since First Exposure to Vinyl Chloride 14. Observed Deaths by Cause and SMRs for all Cohort Members by Age at First Exposure to Vinyl Chloride 15. Observed Deaths by Cause and SMRs for all Cohort Members by Year of First Exposure to Vinyl Chloride 16. Observed Deaths by Cause and SMRs for all Cohort Members by Type of Plant 17. Characteristics of 37 Deaths From Cancer of the Liver 18. Characteristics of 23 Deaths From Cancer of the Brain and Other Central Nervous System 19. Characteristics of 41 Deaths From Emphysema VW 000002434 Sunnary i The cohort consisted of 10,173 men who had worked for at least one year in jobs involving exposure to vinyl chloride prior to January 1, 1973. These men were employed at 37 plants in the U.S., belonging to 17 companies. Observation of the mortality experience of the cohort was extended to December 31, 1982. A total of 1536 cohort members were identified to have died. The observed mortality, by cause, was compared with the expected based on U.S. mortality rates, standardized for age, race and calendar time. Analyses by length of exposure, latency, age at first exposure, calendar year of first exposure and type of products were performed. The study confirmed that the vinyl chloride workers experienced significant mortality excesses in angiosarcoma (15 deaths), cancer of the liver and biliary tract (SMR - 641), and cancer of the brain and other central nervous system (SMR 180). In addition, the study also found a significant mortality excess in emphysema (SMR - 179). On the other hand, the study did not find any excess in either respiratory cancer or lymphatic and hematopoietic cancer. kVy 0oo?435 TABLE 19 CHARACTERISTICS OF 41 DEATHS FRCH EMPHYSEMA, INCLUDING C.O.P.D. CASE PLANT CAUSE OF TEAR OF No. NO. "* ===* 1 15 DEATH * BIRTH .....====== 527.X 1915 2 36 527.X 1903 3 36 527.X 1915 4 14 527.X 1909 5 27 527.X 1913 6 27 527.X 1913 7 27 527.X a 19 527.X 1930 1922 9 12 527.X 1914 10 12 527.X 1895 11 12 527.X 1908 12 12 527.X 1912 13 12 527.X 1896 14 39 527.X 1900 15 39 527.X 1913 16 25 527.X 1903 17 33 527.X 1908 18 33 527.X 1900 19 33 527.X 1919 20 33 527.X 1910 21 33 527.X 1907 22 33 527.X 1921 23 33 527.X 1890 24 33 527.X 1888 25 33 527.X 1904 26 33 527.X 1917 27 33 527.X 1890 28 33 527.X 1914 29 33 527.X 1902 30 33 527. X 1924 31 18 527.X 1918 32 18 527.X 1898 33 2S 527.X 1903 34 25 527.X 1925 35 25 527.X 1920 36 25 527.X 1891 37 25 527.X 1915 38 25 527.X 1892 39 25 527.X 1907 40 25 527.X 1911 41 25 527.X 1914 YEAR OF YEAR OF YEAR OF HIRE FIRST EXP. TERMINATION =========== 1938 1946 1953 1963 1946 1953 1972 1968 1970 1953 1962 1948 1953 1965 1958 1954 1972 1972 1955 1955 1956 1961 1951 1936 1961 1951 1952 1969 1972 1960 1951 1942 1943 1951 1945 1943 1962 1947 1948 1946 1940 1932 1947 1944 1947 1948 1968 1936 1947 1944 1947 1960 1970 1960 1952 1948 1954 1953 1942 1947 1943 1953 1942 1947 1943 1958 1943 1949 1955 1945 1947 1943 1945 1947 1943 1953 1967 1967 1947 1945 1947 1952 1955 1971 1953 1953 1964 1953 1953 1964 1966 1972 1967 1946 1931 1948 1946 1944 1936 1943 1947 1936 1948 1953 1945 1944 1943 1959 1947 1950 1962 1954 1949 1957 1942 1937 1936 1942 1937 1941 1945 1939 1942 YEAR OF AGE AT DURATION OF LATENCY DEATH DEATH EXPOSURE ========= ========= ============== 1982 1974 1978 1977 1976 1978 66 71 62 68 62 65 9.7 22.2 17.3 1.0 7.2 13.6 19 28 25 24 10 20 1965 35 1.3 10 1981 1976 1969 59 62 73 7.8 21.9 7.7 20 25 16 1966 1980 1961 57 67 64 10.8 1.8 5.1 15 34 17 1980 1972 1970 1978 1980 1980 1980 1975 80 58 67 70 80 60 70 67 12.3 3.0 23.4 4.7 3.5 6.7 5.0 1.2 32 4 33 30 36 32 27 33 1977 1966 1962 1971 1971 56 75 74 66 54 1.9 12.1 7.9 20.2 23.6 30 22 16 23 28 1966 1977 76 63 8.2 18.7 19 24 1978 1978 1980 1965 1978 1981 1982 76 53 61 67 74 55 61 13.6 19.9 2.6 11.8 11.0 2.7 9.1 25 25 15 17 42 33 28 1973 82 8.7 27 1974 1970 1979 1976 59 78 72 64 4.8 14.1 2.6 2.8 29 27 37 39 1976 61 1.7 35 = 7th I CD CODES VVV 000002436