Document B5BzZa6L0kJxGyrZo2bn2J7NJ

Current Intelligence 7 i: Angiosarcoma of the LiverTo make an early determination of the distribution and extent of primary liver cancer, and more specifically, in Vinyl Chloride/Polyvinylangiosarcoma of the liver among workers exposed to vinyl chloride, the National Institute for Occupational Safety and Health (NIOSH). Center tor Disease Control, has requested members Chloride Workers of the medical community in the United States and abroad to report information on known or suspected cases. As shown in the table, 26 cases have TaMt 1. -- Hpartaf Cast* a4 Liw tofiMirama to Vtortart [jwii la Vtoyl CMriOa ar Patyiiajt CMoriO*. been reported to date from six countries. Sixteen of these are from the United Caa* lirtl 1*1 e mm n ft Vn t*L >1 If (it. Tn OK* *4 States. Although cases have been ob Urntri R fiat* ttpaama Swat fix la 01 t 0m served from four distinct work areas, the 10 Ranamar ha*Kttn *art*n majority (81%) were formerly employed as reactor cleaners at plants where vinyl r ti-n-n 40-4045 0S-1S-72 11 27 n 4014-72 iS' v. chloride was transformed into polyvinyl Htlivirl* rAfifirmaij <->( CncMdovalM iaiwsalm Harlan At twaimi: nmiic angiosarcoma of tne nver have been reported from four polymerization plants Craat RfitJM Nor*at ST RtMMMtV VblAiid Of 000001 09 00-44 Of 12-2115 0300 50 12 00 72 12 20 71 71 54 24 22 20 1200-72 21 0104-72 in the United States. While an exact SvWm Of 04-21-27 0114-51 02-00 70 43 19 11 1020-70 estimate of the hsk for polymerization Unit* Slataa Of 10-17-23 12 09-41 0343-73 49 22 It 03-03-73 workers must await completion of follow-up, it is already apparent that the disease rate for this group is extremely Iff** Slate* im>m sin Itona* Sut IMtaa Stan OP 0*3913 11 ISIS 0540-70 31 01* tt-ZS-19 1124-4 5 121971 St 04* OUS-24 0704 52 04-1947 43 04* 01-25-12 04 19-44 04-0944 52 14 21 15 20 13 09-2171 21 1219-73 IS 0107-41 tl 040904 high. The total work force currently em UMtaa Stain or 0000-29 011742 020074 45 12 12 AlfW ployed at U S. polymerization plants is about 5,000. No adequate data on poor vinyl chloride exposure levels of polymerization workers is available, but it is thought that past exposures may have frequently exceeded the TW of 500 ppm. For the polymerization workers the median age at diagnosis of angiosar coma of the liver is 45 yean with a range from 36 to 71 years, and the median in terval from first exposure to diagnosis is 20 years with a range from 11 to 30 years. Too few cases have been reported from the other work areas to provide stable estimates of age and latency. Persons interested in obtaining further information should contact |. William Lloyd, Sc.D., Director. Office of Oc cupational Health Surveillance and Biometrics, NfOSH, 5600 fishers Lane, uta Stan Ocutrt StMn 'JM Stain UmtH Saw Uaitta Saw U*M Sata* Uortt Stan U*M Sow *. CaraM* V Orman? C'nl Umt Sana Dana* Saw a. Carmnr Of 05-03 22 080044 000044 45 or 05-04-20 100744 044041 41 or 00-00-31 05 21-45 0341-74 43 ir 01-14-13 0412-51 OS4041 ss if 05-2709 101441 0340-70 41 it 11-1711 091349 0S4249 50 if 120121 00 19 44 0540-74 S3 ir 114427 05-04-50 00 0049 4] 01 07-24 31 U14S7 0040-71 40 02 0404 30 1041 57 004049 39 24 13 29 17 23 20 30 l? 14 It UnawOmk r**MCJtw la. or 0404-14 000044 02 0070 S3 14 000013 041131 0440-73 10 IS' 00-00-25 00-0000 07 00-72 47 24 34 00 earn VC taaanr* 03 004004 000004 004040 41 14 11 032341 IS 0129-41 17 OLIVE 17 05-1001 23 03 11 70 15 050209 30 0704-74 4 03 2709 14 17 14 71 11 01 7509 11 1200 70 Nat* 1 00 0703 73 Rate 2 1 S H 07 15-71 1 00 000000 Nat 4 Not* I nc n witvrt am* W( torn RtfiZ Mac** mtrtfsr cawM) aaetrc* ** nt ala** ntoaa Ham J tamM awi kfeocxa* mmtt Ini Mian M* ra*MI Raa 4 Uatai me can mo vc p*p*aaM Rata 5 Dayint Secant (aawlty "a*peur(M">. tar. f--Wii; X4 natal** toe micaicawaawm cat imam cm la nM tat 50 /j *1 Wl O n Room 3-32. Park Building. Rockville. MO 20652. CMA 01390S CJ kf* Journal of Occupational Medidne/Vol. 16. No. 12A)ecember 1974 809 APPENDIX A