Document B548pjNRGLL9oyyVwB9mYM7Dj

HISTORICAL PERSPECTIVE ON INTER-INDUSTRY VINYL CHLORIDE STUDY 1960-1963 Report published documenting anesthetic effects in animals and humans and liver injury in animals from chronic exposure. 1967 Acroosteolysis reported in humans exposed to high levels of VCM. 1971 Carcinogenicity of VCM discovered in animals, including angiosarcoma of the liver. 1973 CMA sponsors Tabershaw-Cooper Associates to conduct an epidemiologic study of 8,384 vinyl chloride workers from 34 plants. 1974 First reports of angiosarcoma of the liver cases in VCM workers. 1974 Tabershaw-Cooper report preliminary results confirming high risk of angiosarcoma of the liver and suggesting excess cancers of respiratoiy system, brain and lymphoma. GGB 3/15/94 CMA 116576 HISTORICAL PERSPECTIVE ON INTER-INDUSTRY VINYL CHLORIDE STUDY (cont.) 1974 OSHA holds hearings and revises PEL down to 1 ppm. 1981 Cooper expands original epidemiology study to include 10,173 workers from 37 plants-- reports show angiosarcoma and brain cancer to be in excess through 1972. 1986 EHA updates inter-industry study with follow-up through 1982reports angiosarcoma, brain cancer and emphysema to be in excess--no excess respiratoiy cancer or lymphoma/leukemia. 1991 EHA study is published. 1993 CMA letter to the editor and EHA response are published clarifying the brain cancer and emphysema findings. 1994 GGB 3/15/94^ CMA Vinyl Chloride Research Coordinators meet to discuss updating study. CMA 116577 > "The study carried out by Environmental Health Associates on behalf of the U.S. Chemical Manufacturers Association is the largest and most informative investigation thus far undertaken." Sir Richard Doll Scand J Work Enviorn Health 1988; 14:61-78 GGB 3/15/94 CMA 116578