Document B30dv7p0wq3VwRrNwo3jnjwE

Castleman File: American Petroleum Institute w/c = with cover letter or memo If DATE = 0, undated CD-ROM Document #:API ^ DATE published article from trade journal published advertisements newspaper article published government report government inspection results unpublished or internal report unpublished presentation from conference letter memorandum industry warning labels industry sales literature industry recommended practices meeting minutes (with attachments) /^ membership list BC notes Fcr Info:ration Only - ;Jct For Publication AFRICAN PETROLEUM INSTITUTE LOGICAL ADVISORY COMMITTEE Minutes of Meeting November 16, 1945 Stevens Hotel Chicago, Illinois T'. Rcev' r! -.on/ii - . 'V. 0. Armstrong V. C. 3aird F. F- Boys jrryRERS ABSENT: D. M. English R. A. Jewett ASSOCIATES PRESENT: E. v;. Adams L. C. Beard, Jr. R. s. Bonsib Reiver Moody - Chairman D. V. Stroop - Secretary T. Li. Frank A. E. Hoag J. P. Holt M. N. Newquist B. B. Reeve 0* S. Somervili (Rep. by V..M. V/. R. Levis A. Morrison J. F. Peattie * * H.`6. Thomson K. C. Cole Nelson J. Cothard H. P. Lankelma H. R. "Jarrick F. id. ' Aitkins Robert ?:enoe, Id.D. - Kettering Laboratory, University of Cincinnati. I ...IMUTES OF PREVIOUS NESTING Action: The minutes of the meeting held i!ay 7-8, 1945 at St. Louis were approved as circularized. A- II REPORTS OF SUBCOMMITTEE CHAIKIN Subcommittee on Carcinogenicity - M. N. Newq'iist, Chairman. Dr. Newquist presented a formal report with outline of proposed research project and copy of the form of agreement required by the University of Cincinnati in its toxicity investigations. (See Appendix A to these minutes.) API 06773 2- - jr. yehoe ;-.nd the members discussed in detail the report, the outline of work, and tnc lore, of agreement. Acticn: 1. Tlic report of the cnaiman was accepted 2. It was agreed unanimously that the type of agreement required by the University of Cincinnati should be signed, if necessary, in order th^t the i.;edical advisory Committee may promntly nrogress the selection of a suitable investigator. 3. It was agreed unanimously that the Kettering Laboratory of Applied Physiology should be selected to initiate the investigation on carcinogenicity as outlined by the subcommittee. 4. It was agreed unanimously that the matter of selecting samples for the investigation should be referred back to the Subcommittee on Carcinogenicity with power. B Subcommittee on Chlorinated Compounds - F. F. 5oys, Chairman. Dr. 3oys presented a formal report which was discussed at length by those present. (See Appendix B to these minutes.) Action: 1. With slight amendments, the report was accepted. 2, The secretary was requested to transmit copies of the report to directors of the American Petroleum Institute with the suggestion that the report may be of interest to medical, legal, and cutting oil sales departments. C- Subcommittee on Permissible ConcentrationsV. C. 3aird, Chairman. Dr. 3aird presented a formal report, a copy of which is attached as Appendix C to these minutes. action: 1. 7,'ith a few additions to the lists of industrial toxic materials, the report was accepted. 2. The secretary was requested to send duplierte copies of the list of industrial toxic materials to all members and associates and to ask them to return one copy upon which the listed materials, and any additional materials, are classified into three groups so ns to indicate three degrees of need for prompt publication of data. Subcommittee on Ijedicrl Policies ; nd Practices - R. A. Jewett, Chairman. In the absence of Dr. Jewett, the subcommittee report was presented by Dr. Frank. (See ..ppendix D to these minutes.) API 06774 -3- action: 1. Th: reoort cf the Subcommittee on Medical Policies '.nd Practices ,,t;s accepted with expressions of appreciation for the splendid service contributed by Dr. J.-wett. . .2 The chairman ms asked to make additional appointments to thcmtr.bersliip of the subcommittee to replace those vmo have indicated their inability to serve. Ill 3UDj3TS FOR 1946 COIL.ITTES ..CTI7ITI3S cticn: Daring the meeting, 1946 budgets were established and funds were allocated for activities as follows: (H) .t budget was established and ,>k,500 of the Medical Research Fund were allocated to initiate the library research on permissible concentrations, as recommended by the Subcommittee on Permissible Concentrations. (3) A budget was established and .-{6,000 of `the 'Medical Research Fund were allocated to initiate the investigation to be conducted by thu Kettering Laboratory. (C) nn unspecified amount of the Medical Research Fund was authorized for expenditure in the purchase of a library of 10 authoritative books on toxicology and a suitable shipping case so that arrangements could be made to have such books available at future meetings of the Medical Advisory Committee. IV C.::iES IN CG-MITTZI C,JAJ.TZ..TICNulTI) PSCCSDURE etion: 1. The committee regretfully accepted the resignation of Doctor I. S. Purcy. .2 The members agreed unanimously that Dr. Moody should continue as chuim-ji during 1946. 3. The chairman was requested to consider and to make several changes in subcommittee memberships. (These will be announced in the near future.) Chairmen of subcommittees were requested to prepare their reports at the earliest practicable date so that copies may be circularized in advance of each meeting. Note by Secretary; Such prior circularization will be done by ,_PI Headquarters for rooorts received not later than 30 days prior to a meeting. 5. The secretary was requested to circularize copies of a revised list of memoirs and associates complete with F.C. addresses. API 06775 -4- V business -ort;:ria in Cutting Oils Dr. H<"ig read memorandum dated November 2, 1945 from Janes T. Beard, Jr. as follows: "The report of the Subcommittee on Chlorinated Compounds of the ,,PI Medical Advisory Committee, dated October 16, should be of interest to all marketers of cutting fluids. VJe feel that it is an important step in calling attention to the possible effects of various types of chlorinated materials, ife are quite in agree ment with the conclusions that have been reached. try/e are now suggesting that other phases of this problem are worthy of investigation -- namely, those phases that deal v.'ith bacteria, the effects of bacteria on operators, and the control of bacteria in all types of cutting fluids. Ue suggest the following line of investigation! (a) An investigation of the various types of bacteria t found in used cutting fluids, both non-soluble and soluble -- th- pathogenic groups, and the faculta tive anaerobic groups; ll I I tI (b) The rate of growth of the various bacteria in various types of fluids -- 1. Mineral oil 2. Mineral oil and fat 3. Mineral oil and sulphurized fat 4. Sulphurized mineral oil 5. Sulphurized mineral oil rind fat 6. Sulphurized mineral oil-ind sulphurized fat 7. Mineral oil and chlorine 8. Sulphurized mineral oils and chlorine 9. Soluble oils and soft water 10. Soluble oils and hard water (c) The effectiveness of various germicides on the various groups of bacteria, and the percentages required to keep cutting fluids sterile. "This is an extensive program, and it may not be practical, or even possible, to carry out in its entirety. However, any steps that can be taken to enlighten us and the general public along these lines will be very beneficial." Action: The subject was referred to tht Subcommittee on Chlorinated Compounds for study. VI ,xSA CC)VJTTTZ ON TOXIC DUSTS <iND GaSES (237) API 06776 The secretary requested the committee to nominate a member and an alternate to serve as API representatives on Committee 237. -5- nCtion: The committee nominated Dr. 7,foody :*.nd iir. Bor.sib ns the member md alternate, respectively. VII ::zxt ihztiijg ,cticn: It was agreed that the next meeting should be held in Cldcngo cn Monday, April 8, 1946, which is the first day cf the 1946 meeting of the ,inerican Association of Industrial Physicians and Surgeons. mi ADJCURi&SNT As there was no further business to cone before the meeting, it was adjourned. Approved Reiver ".foody Chairman D. V. Strcop Secretary Becember 3. 19I15 API 06777 APPENDIX A For Information Only - Hot For Publication IlZPOHT OF SUBCOMMITTEE ON CARCINOGENICITY TO: DR. McIVER 'TOODY CHAIRMAN. MEDICAL ADVISORY COMMITTEE - API On August 13, 1945, a meeting of the Subcommittee on Carcinogenicity called in New York. Those who attended were: Dr. il. N. Newquist Dr. A. E. Hoag Dr. I. E. Percy Dr. Mclver Woody R. S* Bonsib L. C. Beard H. R. Warrick D. V. Stroop Dr. R. A. Kehoe (guest) *4 *! At this meeting, the objectives and procedure for study of Carcino genic properties of hydrocarbons were presented in outline form to Dr. R. a. Kehoe to see if he and the Kettering Laboratory would undertake to make the study. Dr. Kehoe seemed to be interested in making the study, but he wished to consider it further before coming to a conclusion. In a letter to Mr. Stroop dated August 28, 1945, Dr. Kehoe stated that he wished to have two matters clarified before proceeding further, namely, (1) a formal agreement under which the work of the Kettering Laboratory was to be carried out (copy of agreement form attached), and (2) He wished to have a clearer understanding of the particular problem in question. Since there was a difference of opinion ainong members of the Subcommittee as to whether the contract should be signed in the form submitted by Dr. Kehoe, a meeting of the Subcommittee members in New York (Newquist, Woody, Hosg, Adams, Beard, Warrick attended) was called on September 2Jth in New York for further discussion, and for a tentative selection of petroleum products to be studied. The difference of opinion with respect to the contract still existed ?t the close of this meeting, so iir. Stroop was requested to write Dr. Kehoe for further clarification of certain phases of the proposed contract. This was done fcy iir. Stroop on September 25, 1945 - which included an invitation to Dr. Kehoe to attend the meeting of the Medical ndvisory Committee in Chicago on November 16, 1945. In a letter to Ur. Stroop dated October 13, 1^45, Dr. Kehoe advises to the effect that the Kettering Laboratory could not undertake to make our proposed study unless the contract submitted by the University of Cincinnati was signed by the American Petroleum Institute. Dr. Kehoe may wish to amplify his position personally at the meeting on November 16th. Since the signing of the proposed contract involves a matter of policy of the API, it is suggested that the recommendation of the Medical .-.dvisory Conrdttec of the API be obtained in this connection before proceeding further. API 06778 Respectfully submitted. 9 Dr. il. ii. A'ewquist, Chairman . Members: Dr. 4. N. Newquist Dr. ... E. Hoag Dr. Joseph P. Holt Dr. I. E. Percy Dr. 'Dr., R. Levis November 16, 1945 dr. H. R. Warrick Mr. L. C. Beard dr. Roy S. Bonsib Mr. H. E. Keranerer API 06779 Fyyy>.D R55I..BCH FRCJICT 0f study of Carcinogenic Properties of Hydrocarbons > _ i.-mediate -- To study carcinogenic properties of those petroleum products ' '..hich, on the basis of present knowledge, are most likely to embody such dualities, (diesel oil, furnace oil, heavy fuel oil, road oils, asphalt :.ni coke) and with which refinery employes and the public are nest likely zc cone into contact, so that any indicated precautionary meas'-ires may be instituted 5 - Future -- To study pure hydrocarbons contained in petroleum products in an effort to determine the presence or absence of specific carcinogenic factors. a '.cedure > - It is proposed that a centralized laboratory adequately staffed and equipped (portions of the study may be assigned to other acceptable rus-arch institutions) conduct appropriate studies in line with the objectives stated above, which would include:v 1. Literature survey of the carcinogenicity of bituminous compounds to date. 2. Examination of samples of petroleum products* which will be submitted at the direction of the liedical advisory Committee, these samples to be subjected to both analytical and animal testing in order to determine their possible carcinogenic properties. It is proposed that these samples be drawn from representative thermal and catalytic ere eking operations, using a wide range of crudes and operating conditions. Control tests will also be run using known similar carcinogens, 3* The develoDment, concurrently and"based upon the above testing of samples, of a chemical and/or physical test which will determine the carcinogenicity of a given material without the necessity of conducting animal tests. b. The development of a means or a method by which the carcinogenic properties of the petroleum product concerned may be neutralized. 3 - Although the incidence cf cancer among petroleum workers is not unfavorable as compeared to that cf the general population, it is proposed, nevertheless, to request information from the medical departments of those companies rnving adequate records, as to the incidence of cancer among their respec tive employes which was ascribed to their occupation (1) in the past, and (*:) in the future. D'"ijstic He. 2 Fuel Oils i. Straight run b. Thermal Recycle c. Houdry or TCC Recycle <i. Fluid Recycle 2. Heavy Fuel Oils a. Straight Residual b. Thermal Tars c. Houdry or TCC Tars d. Fluid Tars API 06780 fl fi P ~XTEIS AG5ESM3TT Made - ' ' A (hereinafter called: (hereinafter called: , between - " "the Donor"), and the TOIYEHSITT OF CINCINNATI, "the University") WITNESSETH __ -: c - ;TVl `I-- UEZ3EAS, -Ar.< fA ^ Jw J n" wishes the Kettering Laboratory of Applied Physiology (hereinafter called: "the Laboratory") to investigate the toxicity and node of action of certain eheaioal products to be mutually agreed upon hereafter from time to time; and WHEA2EAS, the University has approved such investigative wots: *V v by said Laboratory, In consideration of tho mutual promises hereinafter specified, IT IS agheed: , X* 1. The Laboratory shall carry out such investigations v.'ithin I the limits of its available facilities and scientific interests. 2. Tho Doner shall pay the University therefor the sum of Sit * poLUfyg.S on -or beforo /"1 and additional sums in advanco from time to time as may nitually be agreed upon as necessary to prosecute projected experimental work for a definite period of time. At the end of each fiscal year or other period agreed upon for tho completion of a spocific projoct, tho University shall refund to the Donor any unexpended balance of any payment remaining aftor the investigp.tivo work has been completed, or shall apply the balanco to the continuance of such similar work as nay be agreed upon as desirable. 3. The name of the University or of the Laboratory or*of any nonber, officer or employee of the University or the Laboratory, API 06781 c ct r (eentiswed) -2- shrll not be used, in any advertising natter at any tine daring the progress of the work or thereafter. A written report shall be made of the findings and such n report or a photostatic copy therof nay be used by the Dcnor as evidence of the facts established. If the findings are published in a scientific Journal, the Donor shall be free to quote such findings subsequent to publication. 4. The investigative work shall bo planned and carried out by the University, and the University shall have the right to dissemi** nr.tc for the public good, any information obtained* Howovor, before the issuance of public reports or scientific publications, the . manuscripts thereof will be submitted to the Donor for criticism and suggestion. 5. Do person shall be roquirod to make an application for patent based cn any invention, diaccvory or development resulting from any investigative work under this Agreement. IN WIOTD3SS VHERB07 the parties horoto have executed this Agreement by tnoir proper officer, respectively, who are hereby certified to havo been duly authorised to execute tho same. AN&ecfHi Rrgoift/M I^Tiivre 3y_ UNIVERSITY1 OF CINCINNATI through its BOARD 07 DIRECTORS ISeauXh By Chai rnan By Clork API 06782 APF5.DIX B For Information Only - Hot For Publication REPORT OF 3UBC01&ITTEE ON CHLORINATED COMPOUNDS API LZDICiiL aDVISORY COLlilTTEE ms PK03Lai Cutting oils containing several percent cf Chlorinated Compounds have been used in industry. The compounds used have been Chlorinated Paraffin, Chlorinated Naphthalene, Chlorinated Diphenyl and Chlorinated Diphenyl Oxide. These compounds have been employed to improve the finish of the work and to increase tool life* There have been certain objections both real and theoreti cal tc the use of such compounds from the standpoint of the health of the workers. This has been particularly true in the case of the Chlorinated Aromatics. A. Systematic Effects - There have been fatal accidents from the use of Chlorinated Aromatics in the coating of electrical cables when drawn through Chlorinated Aromatics such as the Chlorinated Napht*hilen&. In these cases, large quantities of the Chlorinated Aromatics were held at elevated temperatures and as a consequence material percentages of the product vaporized and establish ed toxic concentrations in the atmosphere. Frequently ventilation was poor. ;.s a result, inhalation of the product occurred nnd was in a few cases followed by systemic effects, notably acute yellow atrophy of the liver. This history naturally has made the use of Chlorinated aromatics suspect. B. Dermatological Effects - Denaatosis from cutting oils, containing only petroleum hydrocarbons, is not unusual when conditions of uncloanliness obtain and when the workers are allergic to petroleum hydrocarbons. Uore recently recognition has been given, especially by Dr. Louis Schwartz of the U. S. Public Health Service, to a specific type of dermatosis which he has named Chlcracne. Dr. Schwartz has published several -papers on this subject. The investigations were said to deal with the Chlorinated Aromatics. The problem of the Subcommittee was to evaluate the importance of both the systemic and dermatological effects cf Chlorinated Compounds as related to the health of the workers using cutting oils containing them. REVIEW OF LITERATURE nND ACCUMULATION OF DAT,. FROM INDUSTRY As the quickest approach to obtaining such information as was available either in the literature or in the files of industrial companies, a questionnaire was sent to two manufacturers cf Chlorinated Paraffins, to a manufacturer cf Chlorinated Naphthalenes, to a manufacturer of Chlorinated Diphenyls and tc a manufacturer cf Diphenyl Oxides. These companies were the outstanding manufac turers and marketers of such products. They were requested to supply any data or the results of any physiological investigations they had on 1. Dermatological effects cf the compounds made by them. 2 - 4. Brief statement as to any serious cases rf dermatosis cr systemic pciscning. 5. T7hat laboratories or institutes they ccnsidered most skilled in conducting investigations of the toxicity cf such compounds as related to their industrial uses. The response tc this questionnaire was unanimous, cooperative, and unbiased. The consensus was that the Chlorinated ^romatics could and did cause serious systemic pciscning, as well as dermatosis, especially under conditions cf peer ventilation and pcor hygiene. The Chlorinated Paraffins cn the other n- nd s-er.; tc be relatively free of these objections. One company reported, "In all cur experience we have been unable tc lccrn cf any evidence that Chlorinated Paraffin ,/ax has either uermatolcgicul cr systemic toxic effects." The other company, quoting the results of a physiological laboratory, said, "These results show that the Chlorinated paraffins made by our processes were not toxic under the condition cf test and did net cause dermatitis." They stated that they had confidence in the laboratory making the tests for them, but they could net guarantee their findings and that it would be necessary fer each user to make their own toxicity and dermatosis studies on the particular combinations that 4they might use. A literature reference on Page 420 of the "Rubber age" August 1943* states, "A. G. Cranch in a recent personal communication tc one of the authors, stated that the effect of these waxes cn the skin resulting in the appearance cf. acne is net determined by the presence cf chlorine alone, but is due rather to J the compound effect of chlorine and a tar derivative. No such marked tendency to acne formation results from exposure to chlorinated petroleum derivatives, such as Chlorinated Paraffin." EXPSRIlfrJfTAL The information given above showed that iry relatively high concentra tions the Chlorinated Aromatics can be harmful. It was felt desirable, therefore, to determine the order of concentrations which might occur in the atmosphere in the locality cf metal grinding and cutting work. To this end three experimental cutting oils were compounded containing Chlorinated Paraffin, Chlorinated Naphthalene, and Chlorinated Diphenyl. The total chlorine content of each of these cils was 3$, equivalent to approximately 6$ of the Chlorinated Compounds, Use was made cf a Vfarner and Swasey turret lathe and a Cincinnati Cylindrical Grinder. These tools were first operated under normal conditions cf feeds end speeds and secondly, with heavier cuts and reduced oil flow in order to induce smoking, analyses were na.de of the chlorine content of the r.ir at distances cf from 16 to 60 inches from the cutting edge. The concentrations of chlorine found ranged from none to 0.55 milligrams per cubic meter of air. The concentration cf Chlorinated Compounds were approximately double this amount since the Clilcrinated Compounds used contained roughly 50$ cf chlorine. The above tests wore conducted in the Technical Service Laboratories of the Socony-Vacuum Oil Co., Inc. and the Carbide and Carbon Chemicals Company assisted in obtaining the analyses. A member of the API Medical Committee was present during the tests. API 06784 Comparison of the concentrations obtained with the permissible limits crted by Dr. C. K. Drinker (J. cf Ind. Hyg. and Tex., Vcl. 21, 1939, p. 157) rlws that in general the concentrations obtained were well below his permissible lirnits, which ranged from 0.5 tc 10.0 milligrams per cubic meter. In seme cases `inker's permissible limit was exceeded. In a private communication, however, t- the members cf the committee. Drinker stated that his limits are predicated cn eight hours per day continuous inhalation. Drinker further stated that he felt it unlikely that in cutting operations a sufficiently high concentration would -ccur tc cause systenic effects. PERSON;! contacts Several of the companies replying recoimended Dr. C. K. Drinker cf Harvard School cf Puhlic Health as an outstanding authority on this subject. On September 26, 1945 Dr. Drinker met with the New York members cf the Subcommittee cn Chlorinated Compounds, As stated above. Dr. Drinker expressed no concern regarding systemic effects when Chlorinated Compounds were used in cutting oils because he felt the concentrations were not sufficiently high. He did, however, sound a warning tc the effect that since Chlorinated Aromatics had under me re rigorous conditions of use caused yellow atrophy cf the liver, any case of yellow atrophy cf the liver, whether rightly attributable to the cutting oil '.r not, would be so construed. This points tc the need for careful medical examination cf employees or prospective employees using* chlorinated cutting oils for liver damage. Additionally, for much the same reasons, workers with adolescent acne or a predisposition to acne as well as these with skin allergies should be excluded from such work. He further mentioned that workers subject tc treatment with arsphenamine and the like should be barred. Ccranenting cn the Chlorinated paraffins, Dr. Drinker said that in animal experiments he had administered enormous amounts cf Chlorinated Paraffin without the occurrence of yellow atrophy of the liver. Ccmmentifig on the dermatological aspects, Dr. Drinker felt that it would be a waste cf money to investigate this phase further. For a competent investigation, there would be a need for human volunteers, who are unlikely tc be forthcoming, in the absence of these, clinical gjsservftions of workers in industry using cutting oils containing chlorinated compounds might supply useful information. It was suggested that consultations be had with the heads of the Departments of Industrial Hygiene of seme of the states. Dr. Leonard Greenburg cf tne New York State Departrrent of Industrial Hygiene was suggested in this respect; such consultation was had and a letter from him is attached. CONCLUSIONS rtll the above leads to the following conclusions: 1. Chlorinated Paraffins appear to be relatively free firm condemnation due tc either systemic cr dermatological effects. 2. The likelihood cf systemic effects by the use of chlorinated aromatics in cutting oils is remote. There are claims in the literature of adverse dermatological effects. 3. Suitable precautions should be taken in the selection rf workers, the verking eenditiens and hygiene. 4. The toxicity cf carbon tetrachloride is well recognized and there fore should net be used as a cutting oil additive. This report should be viewed as preliminary and work is continuing. November lo, 1945 API 06785 STATE OF NEW ALIANY Sf8,, Office lld. *OCHESTE 70 Eicftongc S' YORK UTiCA 104 Poller lldg. division of rtUOSBOAl HTGIFNS ^ jjfD sAfyrr standards DEPARTMENT OF SYRACUSE 214 $o. Worrvn &t. BUFFALO Sta** Office Bldq. LABOR BINGHAMTON S02 Pr*M lldq Hew York City, 15 November 7, 1945 jr. A. Z> Hoag Medical Department Socony-Vaeuum oil Co. 26 Broadway Now York City, N. T. * Dear Sr. Hoag: * have read over the draft of the report of your sub-cocmiittee on chlorinated compounds of the A.P.I. Medical AdTieory Committee, pre pared by you and Dr. Beard and dated Oetober 16, 1945. With reference to this report, I would like to aay that wa believe the use of chlorinated paraffine to ha relatively free of hazard and esaentlally we agree with your flrat coneloalon. with reference to the use of chlorinated aromatic compounds in cutting oils, we believe there la a very real poasljollity and even likelihood of producing dermatitis and that the incidence of thie nay be quite high, particularly with long, continued exposures, with reference to systemic poisoning, we believe the possibility to be far acre remote but, nevertheless, we feel that Industry should be fully warned as to such a possibility and instructed just how to utilize precautionary measures. I trust this answers your purpose but should any further questions arise, please do not hesitate to call on me. IN REPLY PLEASE ADDRESS WRITER API 06786 For Information Only - Hot For Publication REPORT OF SUECO&ITTSE FOR Pac.2S3I3LL COXEKTR/.TIONS CF TOXIC SUBSTANCES IN THE PETROL Z7J-J INDUSTRY We have outlined the scope of our assignment as follows: 1. To prepare a list of the toxic substances used and produced in the petroleum industry. 2. To collect and publish information on those substances in the above list v/hose toxicology has already been established. 3. To select those of the subjects remaining on the above list which are of sufficient and general importance and on which satisfactory toxicological information has not been determined, and to develop a research program for their study. We have prepared a tentative list of the toxid Substances used in the petroleum industry, llany of the compounds are listed by type only, thus eliminating in this list an enormous number of possible homologs, for example, "naphthas," "mercaptans," and "phenolic homologs." 1 copy of this tentative list is attached. We propose to develop the following information in connection with the second objective listed above: I. Marne of substance II. Properties and Characteristics - Physical and Chemical III. Uses in Petroleum Industry , IV. Toxicology a. Acute effects, including symptoms b. Chronic effects c. Safe limits V. Treatment VI. Examinations - a. Preplacement Examination b. Periodic heexamination 1. Frequency 2. Extent VII. Safety Precautions - a. Working Rules b. jihfint VIII. Bibliography API 06787 To prepare this information, we have entered into negotiations with Or. Cecil K. Drinker, Professor of Physiology and head of the School of Public Health cf Harvard University. Dr. Drinker has agreed to undertake this assign ment. jjuch of the library and research work will be dene by a graduate student,