Document 9n0Ka9M4V97o4p720XZYK8e7

Aktt OhU/ STN INTERNATIONAL CA FILE SEARCH RESULTS - SD71175P 01 MAY 89 DB:44:49 L21 ANSWER 8 OF 26 PAGE Or' S AN CA110(18):159713w TI Delayed effects of vinyl chloride occupational poisoning AU Antonyuzhenko, V. A. CS Inst. Gig. Tr. Profzabol. LO Gorkiy, USSR SO Gig. Tr. Prof. Zabol., (2), 39-41 SC 59-5 (Air Pollution and Industrial Hygiene) SX 4, 45 DTJ CO GTPZAB IS 0016-9919 PY 1989 LA Russ AN CA110<18):1597l3w AB Anal, of clin. data on 102 patients <52 males and 50 females) followed up for 7-26 yr after occupational poisoning with vinyl chloride (I) revealed a specific role of the nervous system in the development of the clin. manifestations of poisoning. Occupational exposure to even low concns. of I can cause pathot. changes of the nervous system, which can lead later to organ pathoL such as heart diseases and neoplasms of brain and stomach. L21 ANSWER 9 OF 26 AN CA110(18):159708y TI Fire and explosion hazards of methylchloroform AU Denisenko, I. S,; Bondar, T. I.; Krivulin, V. N.; Kudryavtsev, E. A.; Frolov, Yu. E.; Evlanov, S. F.; Bratolyubov, A. S. LO USSR SO Khim. Prom-st. (Moscow). (1), 22-3 SC 59-5 (Air Pollution and Industrial Hygiene) SX 50 DT J CO KPRMAW IS D023-110X PY 1989 LA Russ AN CA11D(18):159708y AB The vapor pressure and flammability limits of pure MeCCl3 and its stabilized com. forms are compared. ASI 00004929 CAS ONLINE ASI 00004930 SDI154 User:004736 04aug69 PR 49/7/1-ISO ((tens 1-36) DIALOG SOI PRINTS for UP-3909________________________ DIALOG File 1S4: MEDLINE 83-89/SEP (890902) 06965567 89267567 Biochemical effects of three carcinogenic chlorinated methanes In rat liver. Kltchln KT; Brown JL Environmental Toxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27211. Teratogenes1s Cardnog Mutagen (UNITED STATES) 1989, 9 (1) P61-9, ISSN 0270-3211 Journal Code: VM9 Languages: ENGLISH Thre chlorinated methanes, carbon tetrachloride, chloroform, and methylene chloride, known to cause liver turn rs In rodents, were given by oral gavage to adult female rata both 21 h and 4 h before sacrifice. Then hepatic DNA damage, ornlthine decarboxylase (00C), cytochrome P-450, glutathione ontent, and serum alanine aminotransferase (SGPT) activity assays were performed. Carbon tetrachloride Increased rat hepatic ODC activity and decreased cytochrome P-450 c ntent at doses both below and above cytotoxicity (as measured by Increased SGPT activity). At 54 and 160 mg/kg, chloroform Increased hepatic ODC activity with minimal or no elevation In SGPT activity. At 480 mg/kg chloroform Increased hepatic ODC and SGPT activity. A dose of 1,275 mg/kg methylene chloride caused a small, but significant amount of hepatic DNA damage. When these three compounds are compared on either an equimolar r equltoxic (1/5 LDSO) basis, their ability to Induce hepatic ODC or Increase SGPT activity was carbon tetrachlorld greater than chloroform greater than methylene chloride. The results of this biochemical study are Interpreted with respect to the ability of chemicals to cause hepatic cancer by either genetic or epigenetic mechanisms. 06965227 89267227 [Fluorine toxicity In fluoride prophylaxis] Conslderazlonl sulla tosstclta'del fluoro flu roprofllassl. Zab rra G; Clcclu D; Verzt P; Leonard1 R Stomatol Medlterr (ITALY) dul-Sep 1987. 7 (3) p387-95. Journal Code: UZI Languages: ITALIAN Summary Languages: ENGLISH Ooeument Type: English Abstract; Review (19 Refs.) In 06984052 89266052 The effect of ammonia Infusion on brain monoamine metabolism In portacaval-shunted rats. Bugge M; Bengtsson F; Nobin A; Jeppsson 8; HultbSrg B; J nung T; Herlln P Dept, of Surgery, Lund University, Sweden. Res Exp Med (Berl) (GERMANY, WEST) 1989, 189 (2) p101-11, ISSN 0300-9130 Journal Code: R67 Languag s: ENGLISH The effect of ammonia Infusion on m noamine metabolism was studied In the rat brain. Seven days after portocaval shunt (PCS) or sham op ration animals were Infused with ammonia r PAGE: 6 Item IB of____36 saline. Brain metabolism of serotonin and norepinephrine was studied after Injection of a decarboxylase Inhibit r (m-hydroxybenzylhydrazlne, NSD 1015) which blocks the conversion of 5-hydroxytryptophan to serotonin and dlhydroxyphenylalanlne to dopamine. Neurologic testfng w s conducted before killing. Plasma and brain antno acids were measured. PCS animals Infused with ammonia were In deep coma after 6 h Infusion, whereas shan-operated animals were virtually unaffected. Brain amino acid analyses demonstrated Increased concentrations of the aromatic amino acids and a tenfold Increase In glutamine. Serotonin metabolIsm was diminished after 6 h. Dopamine synthesis was normal, but norepinephrine levels were low after 6h. The study suggests that hyperammonemia In PCS rats results in a depression of the serotonin synthesis rate In accordance with tw previous studies but In contrast to previous hypotheses on the regulation of serotonin metabolism. 06962953 89264953 Conjugated diene production after airway acid aspiration. Stothert JC Jr; Basadre JO; Herndon D; Traber L; Traber D Department of Surgery, University of Texas Medical Branch, Galveston 77550. Prog Clin Biol Res (UNITEO STATES) 1989, 299 p69-74. ISSN 0361-7742 Journal Code: PZ5 Languages: ENGLISH 06960484 89262484 [Effect of vinyl chloride and Its polymers on the nervous system] WpLyw chlorku wlnylu 1 jego pollmerow na ukLad nerwowy. Kurzbauer H lastytutu Medycyny Pracy w Przemysle Wegtowym 1 Hutnlczym w Sosnowcu. Neurol Neurochir Pol (POLAND) Sep-Oct 1988, 22 (5) p404-9,-9 ISSN 0028-3843 Journal Code: NYF Languages: POLISH Summary Languages: ENGLISH AW.- Document Type: English Abstract Jtf The study was undertaken for assessment of the effect f vinyl chloride and Is polymers on the nervous system. A group of 200 patients working in the production of VC were studies. The group comprised 155 men and 45 women aged 19-46 years (mean 40). The duration of employment was over 5 years in most workers (85.5%), and 26% worked over 20 years (mean ekjrat1 n 14 years). On the basis of neurological examinations clinical groups were Isolated: without neurological changes (58 workers), with symptoms (54), with organic signs (68). The studied groups were not different with respect to age. The shortest durat1on of employment was 1n workers wlthout neurological abnormalities. In the complex of symptoms tension h adaches. Irritability and sleep disturbances prevailed. Organic signs manifested themselves most frequently with pyramidal abnormalities (52), cerebellar (40), sensory (cont. next page) ____ _______________ ___DIALOG = INFORMATION SCRVICCS. INC. 1154 User:004736 '03nov89 >R 49/7/1-150 (Items 1-54) DIALOG SOI PRINTS for UD-6912 DIALOG File 154: MEDLINE 83-89/DEC (891202) 7/ (' J Item PAGE: 38 of 13 54 P26-50, ISSN 0273-2300 Languages: ENGLISH Journal Code: RBH 07064978 89366978 [ Exper latenta 1 models of multiple sclerosis] Document Type: Review Doswladczalne models twardzlny uogolnlonej. j A methodology for using physIlogical1y based Slerakowsk1 SJ; Kucharz EJ pharmacokinetic (PBPK) models to derive predicted safe Postepy Hlg Med Dosw (POLAND) Nov-Dec 1988, 42 (6) p619-4, 5 c ncentratlons of noncarcinogens In drinking water for humans ISSN 0032-5449 Journal Code: PEU l based n experimentally determined no observed adverse effect Languages: POLISH Summary Languages: ENGLISH levels (NOAELs) In animals Is presented and applied to the Document Type: English Abstract; Review case of 1.1,1-trlchloroethane (methyl chloroform, MC). For (91 Refs.) each toxic endpoint and lowest corresponding NOAEL Identified f r MC, we considered a set of toxicologically plausible opt 1 ns regarding the presumed toxic agent and the metric for effe tlve dose to target tissue. A four-compartment PBPK model for rodents was used to estimate correspondlng effective doses to the animals used to obtain the experimental NOAELs. A five-compartment PBPK model was then applied. In conjunction 07064429 69366429 Carbemyl phosphate synthetase and ornithine transearbamy1asa activities In enzyme-deficient human liver measured by radiochromatography and correlated with outcome. Tuchman M; Tsai MY; Holzknecht RA; Brusllow SW < with a multiroute (Inhalation, Ingestion and dermal) Department of Pediatrics, University f Minnesota. human-exposure scenario, to calculate alternative Mlnneapol1s 55455. concentrations of MC In drinking water predicted to result In Pedlatr Res (UNITED STATES) Jul 1989, 26 (1) p77-82, orrespondlng effective doses to the same target tissues In humans. In the case of MC, the PBPK approach to interspecies ISSN 0031-3998 Journal Code: OWL Contract/Qrant No.: N01-DK-6-2274; HD 11134 and Interroute extrapolation of toxicity data resulted In Languages: ENGLISH lower drinking water concentrations predicted to be nontoxic Sensitive and specifle radiochromatographic methods to to humans than corresponding concentratIons obtained using a measure enzymatic activities of carbamyl phosphate synthetas tradttl nal method for determining safe levels. (67 Refs.) I (CPS I) and ornithine transearbamylass (OTC) w re devel pad. The activities of these enzymes were assayed In frozen liver tissue obtained from 23 individuals with hyperammonemia caused 07065534 89367534 [Occupational angioneurotic disorders provoked by vinyl swnochlorlde and vibration] by CPS I (five patients) and OTC deficiency (18 patients). In addition, livers of one aborted fetus with OTC deficiency and four normal Individuals were studied. The assays us Troubles angioneurotlques professtonnels provoques par le monochiorure de vlnyle et par les vibrations. radioactive ornithine as a substrate followed by separatl n f (jitrulllne formed In the reactions by HPLC and quantitation of Letourneux M; Paris C; Goornay M the radioactivity In both amino acids by a radl activity fl w Instttut de Medeclne du Travail de Basse-Normandle, Faculte de Medec1ne. Caen. monitor or by a scintillation counter. Both CPS I and OTC assays were linear with respect to length of incubation time Phiebologle (FRANCE) Apr-Jun 1989, 42 (2) p233-43, ISSN 0031-8280 Journal Code: P66 and concentration of tissue homogenate. The sensitivity of the methods allowed measurements of CPS I and OTC activities as Languages: FRENCH Summary Languages: ENGLISH low as 0.1 mumol/g/mln on 5 mg of liver tissue and the Document Type: English Abstract Ml roclrculatory disorders of the extremities may have an diagnosis of CPS I or OTC deficiency could be established on as low as 0.5 and 0.05 mg of tissue, respectively. CPS I occupational origin, which It Is desirable to specify. Exposure to vlny.l monochloride results In a chemical nuisance activity In different sections of four normal livers was 3.01 +/- 0.16 muraol/g/mln (mean /- SEM, n 19) and OTC activity which also proved to be carcinogenic In man. Strict preventive was 93.4 +/- 6,3 (mean +/- SEM, n 19). Residual enzymatic measures are therefore enforced In the Industry and activity could be detected and measured In the liver tlssu s ASI 00004931. angl neurotic disorders should no longer be observed. Use of of one of the five subjects with CPS I deficiency'and In 14 of vibrating tools results In a mierovascular response to a 19 subjects with OTC deficiency. OTC/CPS I activity rati In physical nuisance which is difficult to prevent completely. In normal liver tissue was 31.2 +/- 1.3 (mean +/- SEM, n 19), both cases the physlopathology Is not well-known, but whereas this ratio ranged from 343 to greater than 5000 In CPS compensatl n Is possible as occupational diseases. Repeated I deficient livers and from less than 0.02 to 1.55 In OTC trauma of the ulnar artery, and/or Its superficial palmar deficient 1Ivers.(ABSTRACT TRUNCATED AT 250 WORDS) branch are, on the contrary, the main explanation for hypothenar hammer syndrome, which Is easily prevented by mere /Vb>+' adjustment of the work p sit Ion and occupational movements: the condlt1 ns f r medico-legal compensatin f r this particular syndrome, which Is still not listed among JQ ccupatlonal diseases, wll-1 be In effect In the very near future. ___ ___ DlflUOG = A-) 4Acer . W9FOAMATIO* StRVtCCS. I*C.