Document 9kM5e9Qgz1GovrvKMvmxnkD6
Castleman File: American Petroleum Institute
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__ published article from trade journal __ published advertisements __ newspaper article __ published government report __ government inspection results __ unpublished or internal report __ unpublished presentation from conference __ letter __ memorandum __ industry warning labels __ industr/sales literature __ industry recommended practices
jmeeting minutes (with attachments) fa
__ membership list BC notes
AMERICAS' PETROLEUM INSTITUTE SUBCOMMITTEE OH CARCIBOOEHICHT
MISUTES OF ISTEBIM MEETIHQ /June ?. 1949
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An interim meeting of the Subcommittee on Carcinogenicity was held on Friday, June 3rd, 19^9 at 15 Vest 51*t Street, Hew Tork City.
MEMBERS PHESEHT
ASSOCIATES PHESEHT
Marshall Clinton T.M. Frank A.E. Hoag J.P. Holt T.J. Kelly M.H. Hewquist Mclver Moody
QUESTS
L.C. Beard, Jr.
H.P. Lankelma K.Q. Mackenzie R.M. Shepardson (representing H.Q.M. Fischer) H.H. Zuidema
R.M. Faulk - Shell Oil Company A. Mesley Horton - University of Cincinnati
ADVISOR
D.Y. Stroop - API
TOTAL IS ATTEHDAICE - 15
MEMBERS ABSEHT
ASSOCIATES ABSEST
L.S. Curtis M.R. Levis C.A. Swan
R.S. Bonsib AJB. Dooley H.Q.M. Fischer
Minutes of the meeting of March 11th were approved as issued.
Mr. Stroop stated that the API prefers not to he included in the American Cancer Society's list of grants-in-aid for cancer research.
Dr. Horton submitted a progress report. (Copy of the report is attached as Appendix a).
Dr. Moody said the Federal Security Administration has awarded over $450,000. in federal grants for cancer control and teaching activities. The
, 911230 BintulM 01574
largest amount, $35*000. vent to the Pennsylvania Department of Health, vhere Dr. Shllen, Director of the Division of Industrial Hygiene, has set up an occupational cancer control program with a physician and a nurse. At a later date, tvo engineers and a statistician vill he assigned to the project. The attached forms (Appendix B) are being prepared in quantity for use in their surreys and are essentially identical with the form submitted to them by Dr. Hueper to Insure uniform data from the various states participating in the Industrial cancer program. The oil Industries located In the Philadelphia area are high on their agenda.
Dr. Hoag and Dr. Hewqulst spoke briefly concerning articles on cancer they have written for the Secony-Yacuum Hews and Texaco Topics re spectively. It was agreed that other companies copld veil afford to follow their exaaq>le.
T.M. mm.
Secretary
McIYEH KOODT Chairman
$
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iPFHTOIX A.
API.PROJECT ON CARCINOGENICITY AT THE UNIVERSITY OF CINCINNATI
The program at the Kettering Laboratory is roughly divided into, three major phases. Of perhaps most immediate importance is the effort to pin point throughout the industry materials and operations which represent potential hazards from the cancer standpoint. The second phase, which will be prosecuted simultaneously with the first phase, will involve the concentration nnd isolation of the compounds re sponsible for the carcinogenic action of certain catalytically cracked oils which have already been tested biologically. From the physical and chemical properties of such concentrates,
an effort will be made to develop an analytical tool which may
then be applied to any refinery stream to determine its carcinogenicity without resorting to animal testing. The third major phase will be an epidemiological study of cancer
in the petroleum industry.
In carrying out the first phase in the program, as
described above, a series of typical refinery samples will
be tested on suitable laboratory animals to determine their
relative carcinogenic potencies. It is expected that,
in the course of the coming year ending June 1. 1950, testing
of approximately 150 to 200 such samples will Se started at
the Kettering Laboratory. Thus an average of about 12 samples
from each of the following processes will be studied:
,
1. Non-catalytic gas oil cracking
2. Viscosity breaking of residues and ^extracts
3. Naphtha reforming
4. Polyforming
5. Coking operations
~ 6. Houdry catalytic cracking
7. Fluid catalytic cracking
,~
3. Thermofor catalytic cracking
9. Cycloversion
'
10. Houdryflow cracking
11. Hydroforming
12. Slack waxes and aromatic extracts therefrom
13. Solvent extracts from lube oils and heavy gas oils.
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The potencies of the samples will be compared with those of coal tar and shale oil fractions on which clinical data is available from England.
In considering the selection of samples from each of
the processes listed, attention is at present being re
stricted to those intermediates or products with a distilla
tion end point above 650F. On the basis of confidential
information supplied to the Kettering Laboratory by each
of the API member companies on such materials and the unit
operations producing them, a sampling program is being
organized which will cover the current range of variations
in each process. Careful consideration is being given
not only to the characteristics of the particular products
which will be tested for carcinogenicity but to the feed
stocks and the unit operating conditions as well. In this
manner it will be possible to correlate the effect of the
trends in available charge stocks and refining practices
with the relative carcinogenic potencies of products formed.
ThuSj the results of the testing program now planned should
permit prediction of potential hazards as unit operations
change in the years to come.
-
As yet, a list of the specific samples to be tested during the coming year has not been prepared since the necessary data from the individual companies is not complete. However, sufficient information is available to permit the selection of a small number of samples from thermal cracking of high boiling materials, both virgin gas oils and those
previously subjected to catalytic cracking. In additionit is planned to request samples of high boiling oils from TCC units since to date no physiological testing of the heaviest products from these operations has been carried out.
In reporting results of tests on future oil samples, a direct comparison with a solution of a known concentration
of a standard carcinogenic hydrocarbon in a standard solvent will be made. Preliminary tests are being'run with solu
tions of methylcholanthrene in benzene, at concentrations from 0.01% t#, 0.6%. Previous results have indicated that the tumor incidence curves for typical heavy catalytically
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cracked oils may be compared nicely with the curves for
i( - such standard solutions,
*
In further work the effect of the benzene solvent on
the tumor incidence and the induction period in mice will
be determined. Various non-volatile solvents, such as
methylnaphthalene, are being considered for this purpose.
te-*
7 '
However, it must be kept in mind that benzene solutions
ii of methylcholanthrene have been employed as standards for
many years in studies by English scientists. Their use .
tn may therefore facilitate the interpretation of our laboratory
L results in terms of practical hazards to exposed workers.
ii
n
Ai
.n June- 3, 1949. 'ii
A, Wesley Horton
31
ii
j
'911230 BinEulM 01578
APPENDIX B
B3H-C-3
1. Name of Company:
PLANT CANCER RECORD
Date:
2. Location:
S. In Operation since:
4. Products Manufactured:
a. Number of Workers: Total Penales Males White Colored
Office:
Production:
6. Name of Plant Manager; 8. Insurance Carrier:
7. Plant Physician:
9. Carcinogenic Hazards:
10. Operations Involved
a
b
e
d e
f
8
h i i
k
1 n
n
Number of Workers Total. White Colored Male Female
Exposure Constant Intermittent Occasional
11. Type of Exposure
Duration of Exposure
Inhalation Skin Ingestion Other Average Longest
a
b
e
d
e
f
8h 1 J
k
1
Cancers Observed Site Number Period
12. Bate of Labor Turnover:
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(Interim Sub-Corn. Med.Adv.API Meeting held in New York,
Friday, June 3, 9:30 A.M. MOTES FOE THE MEETIHQ Room 673 > ifSy.S5?3tCg^
Sample8 from processes listed in February 1 meeting.
Attempt to show offset of varying feed stocks end operating conditions with minimum number of samples*
Reserve 150 of the 200 samples for refinery samples. Rest on samples for analytical tool from laboratory.
Specific Samples
1. Clarified slurries from FCCB already indicted - some variation shown. 3632 nearly most potent.
2. Effect of thermal cracking on heavy eat. cycle stock.
3. Effect of selected feeds in Houdry and TCC.
4. Highly aromatic samples from 2 and 3 - pass Houdry operation. Does recycling increase carcinogen concentration or destroy carcinogens previously formed!
5. Effect of sulfur and nitrogen Hydrogenation by Union
HCOOH extraction of H bases.
'
6. Slack wax (or slop on outside of presses). Crude sources of those causing scrotal cancers. Rhodessa, E. Texas Ok.
Started 6 concentrations of Me-chol. in bensene from O.OljC to 0.6 3 times a week.
Also 3631 and 3632.
Ask Levis about meeting at Chester, Thursday, June 23.
Kay 31, 1949
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OOCOPATIOKAL CANCER K2C0HD
1, ym*
Residence 3. State:
2. Place of Death: City: Citjr:
Hospital? Street:
4. Sooiel Security No. 7. Date of Birth:
______________i_ Sex Age
8. Tears:
M03.
Days:
6. Color or RaoS: 9. Date of Death:
10. Occupation: 12. Cause of Death:
11. Industry or Business:
Method of Diagnosia
13. Clinical:
Biopsy;
Autopsy*
Other:
J.4.- Name of Physician:
15. Street:
16. Citar:
17. Clinical Diagnosis:
18. ` Pathologic Diagnosis:
19. Primary Site:
20. Date of First Symptoms:
21. Date of First Visit to Physician:
22. Date of First Diagnosis:
-
24. History of OtherIllnesses of Site Affected:
23. Stage of Disease at First Diagnosis: 5. History of Injury to Site Affooted:
APPENDIX B
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ESaHS
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BIS-C-lb
Occupational Oanoer Reoord - Page 2
27. Occupational History: List Occupations in Chronological Order beginning with last or present one.
Bates. !HM TO
HAKE 07 IKPL0TER
. TOPE OP BUSINESS ADDRESS 07 EMPLOY 1 OR FRODUCT MADE
" [1
TITLE OF JOB
Tins: 07 viom psraorafED
1i1
_________________________ 1_____________________
APPENDIX B
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28. Are there any other important materials to which you have been exposed?
(Hobbies; Habits; Medicines; Cosmetios; Diets; Environment)
29. Additional Information Obtainable at:
Name:
\
(Hat Physician; Laboratory; Hospital; Insurance Co; Plant Medical Departrent Clinic; Tumor Registry, etc.)
Address:
Earner
Address:
Name:
Address:
30. Any other Information pertaining to Tumor (Multiplicity, sites, etc.):
i
>
APPENDIX B
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fESH jESS SEU3 K3
b.
BIH-C-2
PLANT CANCER BBOCRD
1. Name of Company
S. In operation slnoe:
5. Number of worker% employed: Kale: Pamela: White: Colored:
*. Name of plant offtotal
8. Insurance Carrier:
10. Operations involved:
In plant: ,, ___
`
IS. Sex of exposed worksrs: lisle:
Female:
14. Duration of exposure: '
Number: Number: Number:
15. Rate of turnover in expos ed group (a)
8. Looation: . 4. Products Manufactured:
In office:
7. Name of Plant Physician
9. Carcinogenic hazards:
11. Number cf workers exposed:
a. Constant exposure b. Intermittent exposure o. Occasional exposure
.
13. Race:
V7hite:
Colored:
Years: Years: Years:
.
'6. Ganoers Observed in exposed group (a) 17. Canoers by attest
Total number:
Period:
*
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