Document 9LyB3kamN78pKL5rm9ZovD0ee

FILE NAME: Chemical Abstracts (CHAB) DATE: 1968 DOC#: CHAB058 OCUMENT DESCRIPTION: Abstract Originally Published in 1965 by Hardy jri ?i e- ! j be practically healthy, 29 to suffer from asthenic conditions, and zone William W. Carlton (Massachusetts Inst, of Technol., 20 from a asthcnoncurotic syndrome and astheno-nervous dys Cambridge). Toxicol. Appl. Pharmacol. 8(3), 512-21(1966) tony. The HgCU blood plasma test of all 3 groups yielded an av. (Eng). Weanling male mice were fed for 7 weeks the chelators of 1.82, as against 1.92 for the controls, and the av. plasma 7- diethyldithiocarbamate, a-benzoinoxime, and biscyclohexanone globulins in cases with slightly enlarged liver was 1.90 g. %, vs. oxaldihydrazone (cuprizone) mixed with chicken mash contg. 1.55 g. % in healthy individuals, while the bilirubin and cho- a 10% lard. Diethyldithiocarbamate or a-benzoinoxime at 0.1% lesterol, as well as the prothrombin, formol, and aldolase tests and 0.5% of the diet did not produce clin. signs of intoxication. generally showed no deviation from normal. The shifts in the Growth was not affected; gross and microscopic lesions were not blood serum protein pattern in exposure to I was not linked with observed in several tissues examd. Growth, reduced slightly by liver damage, but represented a general nonspecific reaction to I. 0.1% cuprizone, was severely depressed by a level of 0.5%. A. A. Horvath _Clin, signs were restricted to paresis in the latter group. Micro Oxidative metabolism in the liver tissue of dioxane-poisoned rabbits. P. A. Rozenbcrg. Prof. Zabolevaniya v Khim. Prom. 1965, 103~8(Russ). Rabbits of 1.5-2.2 kg. body wt. received, by stomach tube, 2.5 ml. dioxane (I) in aq. soln./kg. body wt., followed by repeat higher I doses if there were no clin. symptoms of intoxication, and their blood nonprotein N (NPN) detd. colorimetrically. When the NPN reached 300 mg. %, the animals were sacrificed by decapitation, the kidney cortex comminuted on ice, and the respiratory performance of the pulp, as well as its deamination performance towards DL-a-alanine, detd. following 1-hr. incubation at 37.5 in a Warburg app. and NHj and pyruvate formed in the filtrate were analyzed. Micro-" scopic lesions present at both levels of cuprizone feeding were confined to the central nervous system and consisted of edema, most prominent in the cerebellar cortex, and a noninflammatory demyelination. Edema was, however, also observed in the cere bellar medulla and midbrain. Hydrocephalus and cerebral edema occurred in mice fed cuprizone at a level of 0.5% of the diet. Supplementation of the 0.5% cuprizone diet with 25, 50, or 100 ppm. Cu did not alter significantly the neural lesions induced by the chelator. Only cuprizone feeding interrupted pregnancy. Pregnant mice fed 0.5% and 0.3% cuprizone from the 3rd day of pregnancy failed to deliver young. The former level resulted in a high percentage of nonviable young when scopic examn. of the kidneys revealed a pronounced picture of hydropic nephrosis, with a partial necrosis of the epithelium of the convoluted tubules. In severe cases of I intoxication with high NPN, the O consumption fell to .50% the CO2 forma tion to 37%, the NHj formation to 13%, and the pyruvate to 33% fold, of healthy kidney tissue, while in mild cases, the resp. figures showed only slight deviations from normal. feeding was started on the 9th day of gestation. A level of 0.1% cuprizone did not affect pregnancy when fed from the 3rd or 9th day of gestation. A Cu supplement of 130 ppm. increased the no. of viable young when added to the 0.5% cuprizone diet and fed from the 9th day of gestation, but no young were produced when feeding began on the 3rd day of gestation. RCZB Reversal of a soman-induced effect on neuromuscular function Development of anuria and uremia in I poisoning is due to an without reactivation of cholinesterase. Ted A. Loomis and Den impairment of the oxidative processes in the kidney tissue. nis D. Johnson (School of Med., Univ. of Washington, Seattle). A. A. Horvath Toxicol. Appl. Pharmacol. 8(3), 528-32( 1966)(Eng). The Biochemical changes in the blood in acute intoxications by isotonic response of the anterior tibial muscle of the rat to in some chlorinated hydrocarbons. I. V. Pavlova, P. A. Rozen directly applied dual stimuli was studied in normal and somanberg, N. K. Byalko, and I. A. Gel'fon. Prof. Zabolevaniya v poisoned animals. Indirectly induced dual responses of the Khim. Prom. 1965, 217-24(Russ). The blood of 35 patients with ethylene chloride (I) or CCl* poisoning was analyzed on the 2nd4th day following exposure and subsequently at 2-3 day intervals for a no. of constituents indicative of liver or kidney involvement. In most of the mild cases of poisoning, the bilirubin and aldolase increased slightly, the albumin/globulin ratio dropped, while the phospholipids and cholesterol remained unchanged, all the indices returning to normal within 10 days In cases of CC1< muscle are of equal amplitude in the normal animal at the interstijnulus intervals employed, but, in the soman-poisoned animal, the response to the 2nd of the dual stimuli is impaired. The amplitude of the 2nd response is directly related to the time interval between the stimuli. Maximal effect on the dual re sponse is evident after a dose of 0.1 mg. of soman/kg. This effect of soman which is accompanied by inhibition of acetylcho l_i_n_e_st_e_r_as_e__a_c_tivity, in the anterior tibial muscle can be p_artly_ or poisoning of medium severity, the total blood proteins rose up t o _completely reversed, depending on the dose of soman, by ad9.5-9.7%, due mainly to higher globulin fractions, remaining ministration ro,f rpiipnperirdtyvlmpetVhyivlalannddrronssttannnepdiol without reactiva- higli during the subsequent 6-9 months, while the initially in tion of muscle acetylcholinesterase. RCZB creased aldolase soon returned to normal. In a few cases, the Asbestos related disease. Harriet L. Hardy. Trans. Assoc. activity of alk. phosphatase showed a considerable rise, while the figures for bilirubin and lipids resembled those of mild cases, and Am. Physicians 78, 204-17(1965)(Eng). A review of the occur rence, etiology, and pathol. changes produced in asbestosis, esp. i nonprotein N(NPN) was within normal limits. In a severe I s as an industrial disease. Evidence is impressive that asbestos poisoning case, reported in detail, the blood NPN reached 390 exposure, often delayed in effect, will in the future be responsible mg. % and the indican-test was also strongly pos., witli bilirubin for an important amt. of pulmonary disease, esp. chest tumors. 30 tug. %> indicating severe kidney and liver involvement. In In addn., new evidence points to asbestos exposure as signifi some patients, the blood cholesterol was slightly elevated, while cantly assoed. with abdominal tumors as well. 30 references. in some of the severe cases it was somewhat below normal, a Joseph S. Hepburn possible indication of injury to the cholesterol synthesis function -- Effect of carbon tetrachloride on phosphoprotein metabolism in of the liver. 14 references. A. A. Horvath the liver. R. P. Vinogradova (T. G. Shevchenko State Univ., Comparative psychophysiological studies of alcoholic and non Kiev). Ukr. Biokhim. Zh. 38(1), 27-32(1966)(Ukrain). A 20% alcoholic subjects undergoing experimentally induced ethanol decrease of phosphoserine P was observed 24 and 48 hrs. after intoxication. Jack H. Mendelson, Stefan Stein, and Michael T. intragastric administration of 0.1 ml. of CCI4/ 2OO g. to guinea McGuire (Massachusetts Gen. Hosp., Boston). Psychosomat. f pigs. Specific and relative activities of phosphoserine P in Med. 28(1), l-12(1966)(Eng). To study the possible assocn. creased by 28 and 20%, resp., after 24 hrs., and returned to nor of chronic alcoholism with adaptive changes in EtOH metabolism, mal after 48 hrs. Phosphoproteinase activity (per mg. of P) 4 chronic alcoholics and 4 nonalcoholics were given bourbon equiv. increased by 18% and ATP P diminished by 22%. Specific and to a daily total of 4 g. EtOH/kg. body wt./day for 4 days, taken relative activity of ATP rose by 60 and 50%, resp., after 24 and at 4-hr. intervals. Vomiting and gastrointestinal pain reduced practically returned to normal after 48 hrs. The content of the intake by nonalcoholics to 2.4-3.7 g./day; their serum E tO H -- inorg. P increased by 46 and 50%, resp., after 24 and 48 hrs., levels were lower than in the alcoholics. Though intakes by while its specific activity remained unchanged. N. Jasinczuk alcoholics were max., and they had no gastrointestinal problems, Proteinuria in chronic cadmium poisoning. III. Electro their EtOH levels varied. Before the drinking period, EtOH phoretic and immunoelectrophoretic studies on urinary proteins metabolic rates, estd. from "COj exhalation after ingestion of from cadmium workers, with special reference to the excretion of EtOH-7-MC, were lower in 3 of 4 nonalcoholics than in the alco low-molecular-weight proteins. Magnus Piscator (Karolinska holics; after drinking, rates changed variably. Values for rou Inst., Stockholm). Arch. Environ. Health 12(3), 335-44(1966) tine urinalysis, hematocrit, and serum levels of Na+, K+, Cl- , Ca,+, (Eng); cf. ibid. 5(4), 325-32(1962); CA 57, 62636. In urine P, alk. phosphatase, bilirubin, cephalin flocculation, and thymol samples from 18 of 40 Cd workers, previously studied in 1959-60, turbidity showed no differences before and after drinking, or be there was found no appreciable difference in excretion of to>tai tween the groups. On the 4th drinking day, scrum glutamic- protein in 1962-3, the means being 648 and 672 mg./24 hrs. oxalacetic transaminase levels of nonalcoholics were more th a n _Low-mol.-wt. proteins constituted 10% of the total. Excre- twice the predrinking values; these control values were regained tion of muramidasc was not correlated with that of total protein. by 10 days after drinking. Values did not change in the alco Quant, glucose detn. showed an increase of >200 mg. daily in 10 holics. Kathryn Knowlton subjects, with no assocn., with protein excretion. Fructose was Congenital malformations in lambs reproduced by feeding a present in urine of some subjects and controls. Excretions of a poisonous ra ac unigg ev plan4t. W1 1 ayne Binns,y Lynn * * J * F. jJam m. . . ews,, --an- - d-- amino N and of P were "o--utsi--de normal ---------------- ------ limits in 2 sam_ p- les eac. h. James L. Shupe (U.S. Dept, of Agr., Logan, Utah). South- h There was a marked increase in Cd excretion in one of 6 samples 'western Vet. 17(3), 221-4(1964)(Eng); cf. Am. J. Vet. Res. 103, analyzed, amounting to 130 y/24 hrs. The electrophoretic 1104-75(1903). The presence of a teratogenic agent for ewes in Veratrum californicum tops is confirmed. Martin Jacobson pattern was characterized by an albumin fraction <25% and by a- *large~ 0---g1--lot -bi .u1l!i--n f MfrAact ttni.of tn nat ivf leornafgf iinnf fg '''*"'23.0^) Of ttlC t-Ot&l. A.I* Response of mice to the chelatine avents sodium diethvldithin- htimiri- rt.-al v r n n r n t o t n r n n c f r r r i n w.tylrthtiltw o n r l I r m a