Document 9L9M0xENy4zOeZeG7X4B4oeJ6

FILE NAME: WR Grace (WRG) DATE: July 14, 1977 DOC#: WRG 173 DOCUMENT DESCRIPTION: 1977 Memo to HC Duecker from JC Yang regarding discussion with Dr. W Smith 02/ 12/1996 15:02 6173564887 SS HC PAGE 17 CAMBRIDGE ro: Hfo m . C L Oneciter Julie C. Yang CC; E . S . Wood J. W. Wolter 0. fi. Favorito F. W. Eaton R. E. Locke File: 71-101/2 D~TE SU3jC7 03643216 -July lk, 197? Discussi on with Dr. W. Sciita A call cade to the Health Research Institute revealed that both Drs, William. Smith and Doras Hubert are on vacation from July to September. I then, called Dr. Smith in Seal Harbor, Maine, and discussed the percent survival rate of treated and untreated hamsters. In Dr. Smith's letter to H. C. Duacker (July 5, 1977) the results showed survivals as follows; Samples Treated Total Survival Rata 10C$ Tramolits 55$ 50-?0 Verniculite-'Drenolite 71$ control 78$ |w ji/ *"\ ' Dr. Smith felt this experiment doss not prove that tremolite or trer.clite-veruf.culr.te cotb `ration causae problems other than merethe.ijcn, W:a1 Any foreign material injected into the lung cavity would be a burden to the hamster. In regard to the Delaney Amendment regulations, he is not aware of the effect of abnormal weight changes on the acceptability to animal test data. However, he said 11 the animals were observed daily and weighed monthly, and 'there is complete record of the weights which will ba sub mitted to us in the final report. During their daily observations, if a hamster is changing weight rapidly, they isolate the animal to avoid the loss of the hamster eaten by the others upon death. In general, hamsters tend to gain weight suddenly and develop heart problems, and die of poor circulation. If the animals are kept thin, the cancer development is generally slower which has been, shown, in previous experiments. Excess weight lens is also a warming of disease development. Us 1 U 0 di; bole fibers. nr=arntion of fine small ampli- JCY :glLt Julie C. Yang 15033601 02/12/96 15:03 TX/RX N O .4725 P .017