Document 9L6X0nGdJX9jq3Q56N1p21Rke

38--Industrial Toxicology DOSE OR CONCENTRATION (LINEAR SCALE) Fic 38-2 --Dose/response curves for a chemical agent administered to a uniform population of test animals The slope of the curve can be considered an index of the margin of safety of the material TABLE 38-B COMBINED TABULATION OF TOXICITY CLASSES Commonly Used Term LDm Single Oral Dose for Rats (gm/kg) 4-hr Vapor Exposure Causing 2 to 4 Deaths in 6-Rat Group (ppm) LDtn Skin for Rabbits (gm/kg) Probable Lethal Dose for Man Extremely toxic Highly toxic Moderately toxic Slightly toxic Practically nontoxic Relatively harmless 0 001 or less 0 001 to 0 05 0 05 to 0 5 0 5 to 5 0 5 0 to 15 0 >15 0 Less than 10 10 to 100 100 to 1,000 1,000 to 10,000 10,000 to 100,000 >100,000 0 005 or less 0 005 to 0 043 0 044 to 0 340 0 35 to 2 81 2 82 to 22 6 >22 6 Taste (1 gram) 1 tsp (4 cc) 1 oz (30 gm) 1 pint (250 gm) 1 quart >1 quart From Handbook of Toxicology, Vol 1, 44Acute Toxtcities '* W S Specior, ed Philadelphia, 1956 W B Saunders Co 1116