Document 9Jzxj1vbOn76w10mbkvpD5ZZ3

FOR DU PONT USE ONLY AR226-2755 Copies co E. I. du Pone da Nemours end & ay Haskell Laboratory for Toxicology and Ina .trial Medicine Elkton Rjoad, Newark, Delaware 19711 HASKELL LABORATORY REPORT NO Material Tested Octanoic Add, psntadecafluoro-, ammonium sale* Haskell No. r r.Other Codes Scudy Inltiaeed/Coaoleeed 8/12/80 - 9/3/80 Materia^Submitted_21 CR&O Dept. Haskell Laboratory SKIN ABSORPTION LD50 - FEMALE RATS I Procedure: Two groups of CbR-CDf female rats, 5 rats per group, were clipped free of hair over the back and trunk Area. The cast material, as a 50/30 aqueous suspension was applied to the back of each rat under a square of aluminum foil and held In place with 3" Elastoplast. After 24 hours exposure the rats were unwrapped, sponged off with a mild detergent, rinsed, dried and returned co cages for 14 days observation or until death. Surviving rats were sacrificed. Results: No. of Animals 5 5 Dose (ma/ka) 7,500 5,000 Active Ingredient Averaee Dse (a) 1.38; 0.96 Average Weight (g) Inicial/Flnal 183 226 191 235 Mortality 1/5 0/5 Clinical Siane: 7,500 mn/kg Mild skin irritation, stained face, wet and stained perineal area and :Lnitlal weight loss. Death occurred 3 days after treatment. 5,000 mg/kg Mild skin irritation and intermittent weight loss. Summary: Octanoic Acid, pentadecafluoro*', ammonium salt is slightly toxic in female rats by skin absorption; its LD50 is greater chan 7(500 mg/kg, the maximum feasible dose. All rats, dosed at 7,500 and 5,000 mg/lcg had mild skin irritation and initial weight loss. i i! - 1 - company Sanitized. Does not contain TSCACBI * Ocher Wane: Composition Contaminants: Sapore by: John E. Henry/ Technician Approved by: __ ^ ------------_________ ; Gerald L. Kennedy I Chief, Acuea Investigations Section JEH:jrg Study Director: 0. L. Dashiell Date Issued: Septanbar_22, 1980 j iI I i! f