Document 9JpYZxR0J2RpNkrw33NRG8kB3

June 24, 1966 Mr. Prank Bole Diecast Foreman Briggs & Stratton Corp. N. 124th 8treet Milwaukee, Wisconsin Dear Mr. Boles Dr. Hoamer of our Chioago offioe has asked me to forward toxicity and safe handling information for Pydraul A-200. Animal toxicity studies with iti&e^pz4dttcrt have indicated that the oral lethal dose (DD5500)J to'rate is 10,500 milligrams per kilogram. The lethai doae when the material wae applied undiluted to the unbroken akin of rabbits is approximately 1250. milligrams per. kilogram. fU ^ .rn.Wicv, uuj'itu'#*? vo /a\v^v t-oi- * ft* /\/3Ka/^>0.C We conclude from the above that aooidental ingestion on the part of humans is not a particular hacard in view of the high oral lethal dose in rats. Similarly, single massive skin exposures should not be immediately hazardous. The lethal dose obtained in skin penetration studies is suoh, however, that prolonged and repeated skin contact should be avoided beoause of possible systemic effects. In addition, prolonged and repeated skin contact may lead to skin irritation. We also feel that vapor Inhalation should be avoided when the fluid is heated to elevated temperatures. Such exposure again relates to prolonged or repeated exposures rather thiui short-term massive or acute exposures. In the case of the latter, workmen would not voluntarily expose themesIveB to concentrations that are hazardous beoause of irritation of the respiratory tract. The uae of Pydraul A-200 in industrial hydraulic fluid appli cations should not present toxicity hazards during the trans fer of the fluid from original containers to the hydraulic system. Obviously when the fluid is within the hydraulic system, there should be no exposure and consequently, no hazard. In the event of rupture of hydraulic lines and DSW 018820 STLCOPCB4005364 Mr. Frank Bolz June 24, 1966 Page 2 subsequent splashing or spraying of the fluid on the heated surfaces, vapors of the fluid and possible decomposition products (depending on the temperature of the heated surface) may be irritating if inhaled to the degree that workmen will not voluntarily expose themselves to toxic concentrations. No hazardous exposure should result during the interval required to shut down the system and obtain suitable respiratory protective devloes during repairs to the system. We would not anticipate any greater hazards during routine maintenance of a system containing Pydraul A-200 than would be present if the system contained a phosphate base fluid. It would appear to be good praotice to wipe dry any equipment before doing any welding on surfaces which might be "wetted" with or have a film of either type fluid on them. If the above information does not answer your specific questions please let me know directly or through Br. Hosmer. Very truly yours. R. anmet Kelly, M.D. Medical Direotor REKiroJb cct D. L. Hosmer, Monsanto, Chgo OSW 018821 STLCOPCB4005365