Document 9JbLQXv4RMjyg5prv49arDMEp

IM S' DEPARTMENT OF ENVIRONMENTAL HEALTH KETTERING LABORATORY (5131 872-5700 University of Cincinnati Medical Center 3223 Eden Avenue Cincinnati, Ohio 45219 July 19, 1974 Dr. Mitchell Zavon, Medical Director Ethyl Corporation Ethyl Tower 451 Florida Street Baton Rouge, La. 70801 re. Kehoe Data Study Proposal Dear Mitch: As you requested, this letter will provide an estimate of effort and cost of analyzing Dr. Kehoe*s data and that the initial efforts will attempt to more narrowly define the activities for the project. Dr. Kehoe*s balance studies date back to the late 1930's and involve twenty different subjects. Six of these have been oral ingestion studies only''ftand the remainder, both oral and inhalation uptake studies. Four oral studies, in cluding E.B. , I.F., M.R., and S.W. as subjects, have been reported in some detail in the Harben lectures and in several other papers. The data reported, by comparison to the amount of information available from the studies, was very limited. Data on eleven of 14 subjects used in the more recent inhala tion studies have been published, also in a very limited way. We are now sorting out the large amount of data in Dr. Kehoe's files to identify what all is there. I would suggest four types of analyses: 1. Changes in health parameters during the different rates of oral and in halation exposures. Changes in reticulocyte counts, stippling, ALA, porphoryns, appetite, body weight and several'other parameters have not been reported (nor analyzed, I would judge). 2. Statistical variation. There has been almost no quantitative expression of variation in the many measurements made during the study on each indi vidual or comparing one individual to the next. Seasonal changes could *-2 be important. 3. Kinetics. I would like to quantitate the rates of change and the relation ships between lead in the blood, urine, feces, retention, etc. seen with different rates and types of exposures. The changes at the beginning of the exposures, during week-ends of non-experimental exposures and at the termination of the exposures should be characterized in order to study the rapidity of response and to express these changes on the basis of mathe matical models if possible. _ N15291 xe 001234 Dr. M. Zavon, page 2 4. Contributions to body burden. As I indicated to you, I have some questions about the Golberg and VJetherill studies. If their assumptions are valid, we can compare Dr. Kehoe's data to theirs. Also some of the data from my lead burden studies may be useful here. I will expect to direct under the general guidance of Dr. Kehoe, the study effort and Mrs. Sue Rasche, my assistant, will help with handling of the data. Dr. Peter Gartside, Statistician in the Division of Epidemiology and Biostatis tics, is available for brief consultations and will guide the post doctoral fellow who will be assigned to the project. I propose a one year study to be reviewed at three month intervals to deter mine continuation of the project. Estimated costs are as follows: Personnel: Dr. Stanley Gross Mrs. Sue Rasche Principal Investigator Pcs-fet-Doctoral Assistant Research Technician Secretarial Assistance 50% 25% 50% 10% Fringe Benefits: 15.2% of Applicable Salaries (13,476) Other Direct Cost: Computer Services Misc. Supplies Overhead: 60.00% of Salaries (15,976) $ 8,503 2,500 4,248 720 $ 15,976 $ 2,048 1,000 400 $ 1,400 $ 9,586 Quarterly Amount $ 7,252' TOTAL $ 29,010 Any trips for myself or others in connection with this study would also be borne by the Ethyl Corporation. If you have any questions, please call me at 872-5780 or leave messages at 872-5748. Best regards. cc: Dr. Dr. Dr. Dr. Kehoe Suskind Hammond Gartside Mr. Curtin Stanley B. Gross, Ph.D. Assistant Professor of Environmental Health (Toxicology Division) K 001294 i