Document 9JYyYLXv2Lm6Mr865jr0Oz026
9n&uAt/tiGJ BIO -TEST JlaJyyujJ/ym6>, 3no.
1810 FRONTAGE ROAD NORTHBROOK. ILLINOIS 60062
__ . ^vi'.'cc, Inc. , ITo. 14th Judicial District Cour*tvti ( Calcasieu Parish,, Louisiana 90-DAY STATUS SUMMARY TO MANUFACTURING CHEMISTS ASSOCIATION
- a, ^
CHRONIC VAPOR INHALATION TOXICITY STUDY WITH VINYL CHLORIDE (ETHYLENE DERIVED) FEBRUARY 1, 1974 IBT NO. 663-03222
CMA 001835
tjuduifaial B I 0 * T E S T laif&iatvtiei, Jm.
COUyiSSTJ'TXAl. f't-A ar* In
V.A..
90-DAY STATUS SUMMARY TO MANUFACTURING CHEMISTS ASSOCIATION CHRONIC VAPOR INHALATION TOXICITY STUDY WITH
VINYL CHLORIDE (ETHYLENE DERIVED) FEBRUARY 1, 1974 IBT NO. 663-03222
Date Exposures Initiated: September 10, 1973 Experimental Animals:
Albino Rats, Charles River strain - COBS, Charles River Breeding Laboratories, Inc. Albino Mice, Chalres River Swiss Webster strain, Charles River Breeding Laboratories, Inc. Golden Syrian Hamsters, Lakeview Hamster Colony Organization of Animals: Organization of control and test groups as well as individual animal numbers is presented in Table I.
CMA 001836
TABLE I
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Organization of Test Levels and Animal Number System
Group
Test Level
Rats Males Females
Animal Numbers: Mice
Males Females
Hamsters Males Females
Control None
TE-I
50 ppm
TE-II 200 ppm
TE-III 2500 ppm
1-100 201-300 401-500 601-700
101-200 301-400 501-600 701-800
801-900 901-1000 1001-1100 1101-1200 1201-1300 1301-1400 1400-1500 1501-1600
1601-1700 1701-1800 1801-1900 1901-2000 2001-2100 2101-2200 2201-2300 2301-2400
TE-IV 2500 ppm
2401-2500
r
ki CJc0H P> LH*)t
CMA 0 0 1 8 3 7
tv
StuLtitruaL B I O - T E S T XoJwiaiMiei, !)*tc.
CONFIDENTIAL
Subject to Protective Order in Boss y, Conoco, Inc., :<o. 90-4337
. 14tb Judicial Sistpt C^.irf
iV'-.. Calcasieu PaiHsh Animal Diet: All animals are permitted wate
an
automatic water system. All animals received a standard laboratory diet
consisting of Purina Rat Chow (Ralston-Purina Co. ) up until the seventh
week of exposures. At this time, the diet was changed to Wayne LAB-BLOX
(Allied Mills, Inc, ) because of insufficient supply of the Purina Chow.
Exposure Chambers: Control, TE-I, TE-II, and TE-III chambers are stainless steel and glass in construction, each having a volume of 9. 2M . A 3. 7M^ chamber of all clear Plexiglas houses the TE-IV Group, Photo graphs of these chambers are shown on the following page.
CMA 001838
y*utudual B I U * I t S I Xau&uUtyue-.i, 'Jnc.
PHOTOGRAPHS OF inhalation chambers v!CONFIDENTIAL ........... Subject to Protective Order in Boss v. Conoco. Inc., Ho, SO * <837 14th Judicial District Court iV.u .Calcasieu Parish *. Louisiana
4
CMA 001839
JnduAiiiaJ, B I O - T E S T JlawyLatfriial, $nc.
5
Analytical Concentrations: A Hewlett-Packard 5711A Gas Chromatograph*
and a Carle Instruments** valve system is being used to automatically
sample from each chamber. Chambers TE-I, TE-II, and TE-III all
have three thin wall 1/8" stainless steel sampling lines connected to the
valve system. The Control and TE-IV chambers each have one line.
The lines are flushed out for five minutes at 25 ml/minute before the
sample is drawn into the valve system and gas chromatograph. The
lines are sampled every five minutes sequentially from line No. 1 to 11
during the exposure period. Mean values and ranges of the daily ana
lytical concentration data are presented in Table II.
CONFIDENTIAL Subject to Protective Order in Boss v. Conoco, Inc. , i?o. 90-4337 14th Judicial District Court &i',iCalcasleu Parish* Louisiana
Hewlett-Packard, Skokie, Illinois sis# Carle Instruments, Inc., Fullerton, Calif.
CMA 001840
.CONFIDENTTAT.
Sub-ject to Prot^U7"c7^.r in ^t;-^S2S^lnc^o. <,0-4837
14th Judicial District Court " Calcasieu Parish,, Louisiana
TABLE II
TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Chamber Concentration Data
Day Number
Exposure Number
11
22
33
44
55
86
97
10 8
11 o 12
9 10
15 11
16 o
12
17 CD 18
13 14
19 15
22 16
23 17
24 18
25 19
26 20
TE- I
Range
Mean
39-55 42-51 45-53 45-54 50-56 40-62 51-63 41-61 49-65 38-77 45-69 42-63 52-61 56-64 41-66 43-62 47-78 44-55 43-54 55-69
43 48 50 51 52 57 53 56 58 62 60 60 58 59 47
49 60 51 50 62
Chamber Concentration (ppm)
TE-II
TE-III
Range
Mean
Range
Mean
130-180 164-190 170-214
24-162 182-237 128-332 186-260 115-280 188-274 174-198 160-224
54-266 170-228
84-200 96-178 196-222 202-224 178-208 194-220 200-264
173 181 207
87 218 194
199 164 242 186 202 156 207 162 160 211
219 201 214 242
1820-2610 1700-2600 1290-2550 1190-3600 1160-3100 1600-2850 1990-2610 2240-2840 2010-2650 1150-2900 2230-2690 2400-3100 1750-2480 1870-2666 2200-2630 1990-2510 2470-3000 2220-2530 , 1610-2830 1690-2740
2510 2548 2098 2540 2202 2401 2475 2555 2283 1770 2510 2653 1972 2544 2556
2391 2922 2356
2690 2488
TE- IV
Range
Mean
2030-2880 2240-2600 2140-2590 1980-2490 1900-2580 2000-2480 2300-2980 1850-2310 1970-2690 2390-2930 3010-3570 2430-2920 1160-1920 1150-2400 2320-2610 2540-2640 2370-2560 2570-2980 1810-2150 2390-2650
2355 2467 2261 2293 2330 2329 2675 1915 2192 2481 3236 2733 1664 1794 2545 2612 253 1 2777 1969 2510
TABLE II continued
TEST MATERIAL: Vinyl Chloride {Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Chamber Concentration Data
)ay mber
Exposure Number
29
30 31
32
33
36
37
38 O 39 jj5
40 0
43 44
0 H00
45 w
46
47
50
51
52
53
54
21 22 23 24 25 26 27 28
29 30 31 32 33 34 35 36 37 38 39 40
TE--I
Range
Mean
48-66 47-63 31-51 42-47 29-58 45-60 46-58 48-58 42-55 45-52 45-60 41-58 39-56 47-53 46-55 40-62 43-51 28-55 38-49 45-57
58 56 46 45 51 47 55 52 43 50 52 48 44 50 54 60 50 38 45
49
Chamber Concentration (ppm)
TE-II
Range
Mean
TE-III
Range
Mean
192-248 216-340 200-256 196-232 172-232
92-280 210-242 168-190 188-216 204-212 106-238
98-190 178-240 168-206 210-224 166-198 172-214 190-220 182-212 134-238
219 265 220 206 212 203 225 184
209 209 180 177 215 200 217 171 190 198 193 178
1090-2490 2000-2870 1900-2770 2120-3960 2200-2840 1680-2640 1600-2600 2210-2830 1970-2770 1740-2800 2070-2900 1810-2570 1900-3010 1850-2790 2180-2600 1670-2510 2220-2610 2010-2750 , 1980-2460 1610-2590
1561 2567
2659 2855 2496 1899 2337 2587 2474 2141
2659 1920 2190 2002 2377 2083 2451 2225 2208 2018
TE-
Range
Mean
2400-2560 2030-2710 1960-2600 2020-2900 1360-1920 1530-2000 2670-3350 2070-3510 2590-2890 2600-2930 2610-3040 2250-2610 1890-2190 1980-2560 2050-2350 2310-2920 3160-3670 3090-4090 2530-2740 2070-2540
2488
2105
2295
2441
1655
Iff179)9 f
2998 3356 2686
. g
Is cf fcr *
cCtzT*i 2
g2750
2891 2564
**
O&PH>. PMM*
O^
8?
1920 tf
H
2379a3* rC+O
2213*
2692 3307 3688g
<O+ opO
9 01
O 'ih
CD
*~t
2638. 2525;
a -&Ca.)l a
TABLE II continued
TEST MATERIAL: Vinyl ChLoride {Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Chamber Concentration Data
t/
Day Number
Exposure Number
TE- I
Range
Mean
57 58
59 60 61 64 65 66 67
. 88 71 71 2* 73 74 75 78
79 80 81 82
o t|
o H w
41
47-59
53
42
48-56
54
43
51-59
56
44
46-80
63
45
43-61
52
46
42-58
53
47
114-136
119
48
48-114
84
49
43-60
52
50
24-39
32
51
Equip, failed
-
52
42-51
48
53
45-58
49
54 Holiday
-
55 Holiday -
56
44-60
48
57
48-74
56
58
45-60
54
59
28-49
46
60
42-47
45
Chamber Concentration (ppm)
TE-II
TE- III
Range
Mean
Range
Mean
96-188 148-248 196-262 200-240 178-220 188-210 172-452 146-416 178-240
96-124
-
194-226 178-211
-
-
180-229 304-390 220-364 198-248 214-262
128 219 238 211 195 199 298 255 206 105
-
210 202
-
-
196 347 243 218 240
1950-2900 2240-2660 2400-3100 2110-2680 2040-2780 1690-2690 1140-1750 2240-4000 2280-2590 2180-2460
-
2380-2700 2310-2650
-
2190-2700 1740-2400 2020-2760 . 2060-2500 2080-2580
2686 2579 2835 2344 2640 1968 1659 2910 2498 2348
-
2565 2516
-
-
2445 2141 2404 2333 , 2229
TE
Range
M ean
2210-2630 2610-3220 2900-3310 1560-1990 1920-2340 2040-2660 2550-2670 1160-1940 2500-2610 1520-1700
-
2410-2560 2340-2590
-
-
2320-2620 1375-1870 1940-2580 1940-2560 2100-2800
2310 2616 3203
1752
222215846199-g'/|Ilota
175^;ar5 g
2,1,5617, 33=1 I'MJ2o t*+*1|
" JS> 252& 246f w
tj h
- r< ;i1
-Sfr* o-J. " 9
CONFIDENT TAT, Subject to Protnr-P7TP;rL
V. IS-,1:",
Judicial District Cou"t " ^.Calcasieu Pariah,. Louisiana
TABLE II continued
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Chamber Concentration Data
Day Number
85 86 87 88 89 92 93 94 95 96 99 100 101 102 103 106 107 108 109
no
Exposure Number
61 62 63 64 65 66 67 68 69 70
Q 71 j* 72
o 73 o 74 oo 75 76
77 78 79 80
TE- I
Range
Mean
29-47 47-54 46-80 35-50 50-61 28-53 37-56 40-45 32-46 37-47 29-31 27-52
:Jc ft 38-55 Holiday Holiday 37-55 36-47 36-50
43 49 60 48 53 42 48 42 39 43 29 36
51
-
-
46 43 44
Chamber Concentration (ppm)
TE -II
TE-III
Range
Mean
Range
Mean
TE- IV
Range
Mean
148-216 200-220
98-224 174-220 208-232 136-192 110-302 206-238 170-216 170-230 258-310 168-310
180-230
-
-
228-260 158-248 166-242
191 210 185 211 214 172 209 216 190 199 277 256
-
203
-
-
247 235 201
1620-2280 2160-2560
400-1960 2080-2380 2220-2540 1200-2980 1600-2900 2080-3500 2000-2840 1880-2810 2740-3940 1900-3340
-
1680-2620 -
-
1800-2580, 2120-2600 1960-3020
,
2077 2380 1659 2246 2394 1963 2401 2722 2367 2448 3185
2499 -
2585
-
-
2397 2409 244 8
1220-2500 2500-2940 2320-2720 2520-2680 2320-2520 Equip, failure 2000-2680 Equip, failure 2220-2500 1880-2810 3280-3680 2440-3340
_
_
2210-2640 -
-
2360-2900 2240-2560 2200-2680
2306 2725 2457 2506 2428
2503
-
2328 2448 3516 2578
_
2470 _ -
2633 2464 2400
* Unable to run exposures due to weather.
BIO -TEST A
vO
B IO -T E S T Jc
COffFIp-flTJ-rp j `SRubjeclt't^o Psr^wa+7S;--r~n^
; b`h J"i>lolal District Cert L~" Calcasieu Tarn,, Loui.i.^
TABLE II continued
TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Chamber Concentration Data
Day Number
Exposure Number
TE-I
Range
Mean
Chamber Cone entration (ppm)
TE-II
Range
Mean
TE-III
Range
Mean
TE-IV
Range
Mean
1 13 81 114 82 115 83 116 84 117 85 120 86 121 87 122 88 123 O 89 124 p 90
127 o 91 128 H 92 129 l 93 130 in 94 131 95 134 96 135 97 136 98
21-50 Holiday
37-54 26-55 Equip, failure 45-46 32-54 48-60 20-58 39-52 37-55 39-58 43-55 42-63 35-70 52-77 25-48 40-43
42 -
47 47 45 44 54 44 46 47 51 50 53 53 68 38 41
180-244 -
164-260 178-214
168-232 160-250 140-204 202-388 124-180 196-200 186-226 136-266 180-228 190-250 208-262 135-248 118-200
211 -
201 200
-
199 184 173 295 235
197 200 230 201 220 230 186 172
1620-2520 -
2180-2500 1980-2780
-
1960-2960 2200-2820 2500-2920 2410-3960 1980-2600 1600-2560 1660-2500 1600-2620 2680-3100 1740-2800 2180-2960 1560-3480 2080-2800 :
2306 Equip, failure
- --
2385
1780-2240 2006
2393 -
2100-2380
-
2176
2565 2513
2200-2840 2040-2800
2529 2390
2664
1040-1120 1083
3090
2000-2780 2377
2396
2120-2280 2236
2414 Equip, failure _
2191 Equip, failure -
2145 Equip, failure 2883 One sample only 2900
2259
1940-3000 2333
2624
1700-2180 2180
2983
2080-3660 3513
2410
1860-2700 2170
o
UndMtiteal B I O - T E S T lai&ia&vtied, Dhc,
CONFIDE^. Ial
Body Weight Data: All animals were intervals during the first month of the testing period. Thereafter, the average weight of each group of animals per cage were recorded at monthly intervals. Individual' body weights and group mean weights during the first month are presented in Table III. Monthly group weights and mean weights are shown in Table IV.
Study of the mean weights and weight gains reveal a definite gradation in the hamster body weights from the Control Group through the TE-III Group. The initial body weights were greater for Control and the TE-I Groups than the TE-II and TE-III Groups, especially in the males. A week by week and month by month comparison of body weight gain reveals similar weight gains for all groups in both male and female hamsters except the weight gain between the first and second month and the second and third months of both TE-II and TE-III male hamsters. This discrepancy in body weight gain may or may not be related to the test material. Further body weight data on the next quarterly report may give more of an indication in this apparent effect.
CMA 001846
StuJU*di^ial B I O - T E S T J.alMy\ai&\ie<L, D*tc.
12
Group Sex and Species
Control Male Rats
tro-
CO
h3 o
c\
o 3T1 ^1 * 'P o " -s
t--.
r. <3
oo coo 'H
o3g > _u> M m rZHl 3<0 Tf)
o
P3
TABLE III
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hanlsters
Individual Body Weight Data
Animal Number
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 . 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35
0
206 214 215 186 216 193 177 177 197 190 205 172 190 228 172 160 192 181 195 206 238 232 197 207 212 238 220 180 164 182 198 180 213 144 221
Individual Body Weights (grams)
Week Number: 1 23
253 271 264 250 294 261 263 258 282 267 277 236 267 310 237 215 270 238 259 257 238 237
189 187 198 233 271 250 230 233 247 232
269 201 271
294 304 298
279 348 294
299 300 317
309 315 250 304 368 276
249 308 270 297 304 285 283 220 225 231 266 283 277
269 267 273 250 285 235 310
324 331 350 314 387
329 332 328 358 333 361
291 327 385 305 282
359 305 350 340 326 335 258 327 308 328 330 313 284 304 310 296 326 284 332
4
355 353 368 332 430 359 366 354 387 373 380 324 352 426 342 320 385 328 371 382 353 365 283 352 353 377 370 340 320 351 330 322 363 297 386
CMA 001847
Subject to P ro te ctive Order in
C O H FID EITTIAL
?'-v
9*ult*&&ual B I O * T E S T J.ab&uzio'U&i, Jrtc,
^2ss v. _Conoco, inJ 1' Crd^ in . -14th Judl^THTrri;'0- ?0-40-37 TABLE HI coiSiuae<J0u Parlsb,,
Group Sex and
Species
Control Male Rats
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Animal Number
0
Individual Body Weights
(grams) Week Number: 1 23
_
-4
36 37 38
39 40 41 42 43 44 45 46 47 48
49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68
69 70
200 211 221 203 201 146 132
149 117 164 134 114 141 146 146 200 210 229 212 170 168 - 229 203 224 221 228 245 246 249 232 217
219 211 255 238
268 278
299 266 268 221 200 226 244 236 206 196 230 221 234 251 263 280 266 228 212 277
259 279 263 279 297
289 299 271 267 262 253
291 267
305 305 336 297 311 263 244 268 309 288 255 224 260 245 254 262 273 295 281 265 261 311 297 326 293 310 325 342 352 323 312 314 297 337 305
327 334 382 320 344 297 276 308 349 313 278 287 308 297 302 304 314 340 331 314 313
349 347 377 325 367 394 278 400 371 375 355 356
387 352
356 362 407 349 369 337 303
349 390 328
329 346 336 354 254 340 353
389 394 312
339 362
391 367 364 388 430 300 413 397 394 384 382
420 373
CMA 001848
Jrtduii'ual B I O * T E S T ^a&MattyueA-, 9*tc.
COIfFJJgyy XAL
Subject to Protective Order <n
_gg-v. jonocp, Inc., go. 90-4937
14th Judicial District Court
TABLE III continued111 ?arlsl,e Loulsl^S
Group Sex and Species
Control Male Rats
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Animal Number
0
Individual Body Weights (grams)
Week Number: 123
71 72 73 74 75 76 77 78
79 80 81 82 83 84 85 86 87 88
89 ` 90
91 92 93 94 95 96 97 98
99 100 Mean
210 243 233 237 235 241 250
229 241 213 235 250 211 243 245 231 246 214 221 264 207 223 215 233 217 219 208 203 205 193 205
249 286 260 271 271 295 301 266 283 253 276 287 256 301 289 272 294 264 254 312 236 264 260 280 257 271 258 251 256 238 258
276 335 298 318 320
339 345 304 326 295 310 321 219 355 325 308 342 295 281 344
291 309 303 315 266 303 294
291 297 263 294
327 386
339 360 360
389 412
359 373 341 265 366
339 425 365 371 376 345 314 276 336 351 344 346 301 343
339 343 333 303 335
4
358 415 367 378 375 411 425 385 392 363 290 392 365 433 386 395 392 363 339 289 366 369 362 362 324 368 360 360 352 331 363
CMA 001849
C O N F lpfllJrpf- ^
Group Sex and
Species
Control F emale Rats
cw ctoa ,, : h %n Goj z o a * o>;c-4J q'- p, ,S ^o O3 ^ r*< *-* Dt ti/a" *. iXij: i-cJ-i;i-pH "-H5 M o?*'m_3 tPSi i Cl-H 3 , O 3 -H '5 > +,q}^H2oCJ . Wra| r^i t> PoZfl
15
TABLE III continued
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Animal Number
0
Individual Body Wei ghts (grams)
Week Number: 1 23
101 143 183 211 213
102 16 5 204 210 228
103 150 188 208 214
104 162 210 219 247
105 149 180 215 220
106 163 205 209 240
107 146 186 234 223
108 147 191 210 216
109 152 189 233 226
110 143 171 215 226
111 158 205 219 247
112 140 173 210 211
113 158 198 229 237
114 113 188 215 247
115 166 192 207 218
116 143 176 223 218
117 173 202 228 233
118 132 166 233 189
119 136 168 214 213
120 140 177 249 223
121 179 201 237 237
122 184 208 228 250
123 140 158 232 186
124 174 203 231 239
125
163
186
214
231
126 171 171 233 204
127 137 182 193 214
128 122 160 236 190
129 132 171 185 199
130 154 202 222 234
131 145 192 199 216
132 150 184 198 210
133 141 174 197 201
134 137 182 196 199
135 158 181 211 239
4
216 232 217 246 189 256 232 222 239 232 266 231 232 234 239 238 254 196 228 235 259 270 199 251 249 212 227 201 216 248 222 215 209 212 245
CMA 001850
!)ndttdi/uai B I O '- TEST JtalMytat&ii&l, 9nc.
16
V i.
-a
*$,' v'CP^^-VA0 *
TABLE III continued
s*? v5-'.^
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, tpr Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 123
4
Control Female Rats
136 137 138 139 140 141 142 143 144 145 146 147 148
149 150 151 152 153 154 - 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170
178 188 180 152 151 152 141 148 167 151 171 128 157
129 145 128 146
129 96
172 181 174 185 167 161 173 171 183 176 171 156 193 184 186 177
208 200 205 184
169 203 184 194 218 180 190 166 218 179 198 186 185 178 144 195 213 203 214 191 183 193 182 200 186 187 175 220 207 205 186
238 238
219 215 212
209 242 217 245 215
239 234 233 212 195 204 213 228 213 235 241 240
229 229 220 211 211 218 225 188 222 241 218 226 205
195 238 244 212 201 219 251 224 256 223 248 200 240 214 241 228 218
209 185 223 261 236 251 226 220 237 215 236 221 224 179 259 252 236 227
213 251 261 212 213 231 261 238 263 235 260 221 256 232 257 209 255 227 225 231
279 249 265 235 236 247 224 241 238 233 221 274 256 233 238
CMA 001851
}*td*4di/Ual B I O - T E S T la/t&iattvueil, 9*tc.
COgPUsyTT^,
17
Svtfject to Protective (Vj. Xo*b v. Conoco, In-' - f*7 ln
T7L. r~rr-r^iS^LL ao. 90-4327
TABLE III continue?
Lottie lana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Individual Body Weights
Group
(grams)
Sex and
Animal
Week Number:
SpeciesNumber0123_____________________ 4
Control F emale Rats
171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190
191 192 193 194 195 196 197 198
199 200
Mean
200 156 160 180 183 183 165 146 165 181 174 146
159 196 185 194 151 195 189 162 178 135
159 140 156 173 170 157 175 164
160
222 180
179 207 200 203 185 168 176 204 186 176 172 220 210 211 164 207 211 174 173 158 163 165 168 181 194 182 182 171
188
233 185 194 223 225 220 204 192 192 185 221 184 205 221 221 223 177 225 229 185
191 180 175 179 184 195
209 186 203 187
214
275 202 210
239 262 248 214 202 211 244 229 197 216 257 231 257
191 248 240 197 201 195 191 191 203 208 227 206 217 _____ 2_LQ___
223
275 217 215 252 267 256 225 213 213 240 255 214 225 285 252 256 215 255 265 215 225 211 209 211 219 216 245 214 223 221
235
CMA 001852
9*uiuiiiial
B I 0 * T E S T JlaltoAoifruel, !)*&
._ " * -jJ Sub'ject to ?ro,e
ss.v- Conoco, ti4th JuiS"Jo-' ^*':'J4~34337
.. Calcasieu Parish' V04 Co,Jrt
TABLE III continued
Louisiana
18
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
Control Male Mice
Animal Number
801 802 803 804 805 806 807 808 809 810 811 812 813 814 815 816 817 818 . 819 820 821 822 823 824 825 826 827 828 829 830 831 832 833 834 835
0
30 37 41 41 38 35 36 36 39 39 38 39 36 42 36 38 34 43 35 41 36 39 39 36 32 33 35 27 26 30 31 39 36 38 33
Ind ividual Body Wei ghts (grams)
Week Number: 1 23
'
4
35 38 36 41 36 31 35 38 33 38 34 35 38 40 41 41 37 40 40 42 37 37 38 40 35 38 40 41 36 41 40 43 40 39 39 46 37 38 38 43 36 38 32 41 40 42 41 43 36 37 39 41 40 41 41 42 37 39 39 41 40 42 41 44 33 34 35 43 42 44 43 40 35 36 38 37 38 37 41 40 40 44 44 43 40 40 39 39 40 39 38 38 36 38 37 38 36 37 43 39 39 43 38 44 35 38 39 39 25 32 34 36 28 28 28 30 33 35 35 34 29 26 30 32 36 39 41 42 35 36 37 38 42 44 46 47 38 36 37 40
CMA 001853
Jtiduiiual B I O - T E 5 T lakynato'U&t, 9*ic.
COffFIDSffTTflT.
19
14th j^uTw^ict Court 7 TAB LE III continueflcasieu ^rish,, Louisiana
Group Sex and Species
Control Male Mice
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Animal Number
0
Individual Body Weights (grams)
Week Number: 123
836 27 29 32 39 837 37 41 39 37 838 40 45 44 44 839 40 45 46 48 840 35 38 37 41 841 35 36 33 35 842 27 36 37 38 843 29 31 38 39 844 30 40 34 36 845 35 31 32 33 846 31 34 35 42 847 31 41 39 35 848 35 34 37 37 849 32 36 38 37 850 32 31 31 32 851 34 32 40 41 852 35 40 42 46 853 36 38 39 42 854 40 36 39 38 855 38 39 38 38 856 32 34 38 35 857 - 31 33 35 43 858 36 36 38 41 859 37 40 36 41 860 34 34 35 36 861 33 32 35 37 862 35 24 34 35 863 30 29 31 31 864 36 33 37 38 865 37 35 38 36 866 35 35 34 36 867 17 35 37 42 868 21 41 42 43 869 38 37 38 38 870 39 41 44 46
4
43 38 44 49 42 36 39 43 36 37 43 39 37 38 35 39 45 44 42 38 40 43 40 43 38 37 39 33 41 41 39 37 47 43
46
001854
Jnduituai
BIO-TEST
laJio^aio^iei., 2*tc.
SubjectT;0 Protect
j?oss^ y. Conoco t-i, C.
1,1
Mth ss-gSw : 4837
Calcasieu Parish
?Urt
TABLE III continued
*' oulsiana
20
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 123
.
4
Control
871
37 39 40 40 41
Male
872 34 35 38 39 40
Mice
873 36 40 37 35 38
874
34 35 36
--
875 33 42 36 42 44
876 38 37 33 38 39
877 31 33 37 36 38
878 33 33 32 36 37
879 37 40 40 39 41
880 42 43 44 45 46
881 41 41 41 43 44
882 37 35 35 42 43
883 36 37 35 43 43
884 37 38 37 39 40
885 36 35 36 38 38
886 34 39 36 42 43
887 35 36 39 39 39
888 40 41 42 42 41
- 889
37 40 39 41 42
890 39 39 41 48 46
891 37 37 32 42 44
892 36 36 38 39 40
893 32 31 36 35 38
894 39 40 36 42 43
895 36 36 37 37 39
896 39 39 40 43 45
897 38 39 38 41 42
898 27 31 32 34 36
899 34 33 32 39 38 900 40 40 39 41 40
Mean 35 36 37 39 40
CMA 001855
Group Sex and
Species
Control F emale Mice
i v " i fe ^
jrvJ.*
Li
C0WPID3JTTIAI
Subject to Protective Order in
TABLE III continued
.Conoco, Inc,. No. 90-4337
I4th Judicial District Court
TEST MATERIAL: Vinyl Chloride (Ethyleneaf##^d?arl3h- Louisiana
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Animal Number
901 902 903 904 905 906 907 908 909 910 911 912 913 914 915 916 917 918 919 920 921 922 923 924 925 926 927 928 929 930 931 932 933 934 935
0
32 31 31 29 32 29 28 27 30 28 28 26 28 28 28 28 30 36 32 30 29 28 28 28 30 28 28 28 29 30 26 29 29 30 30
Individual Body Weights (grams)
Week Number: 1 23
30 31 31 30 28 29 30 29 30 29 29 30 28 30 29 28 28 30 28 29 28 23 23 30 24 23 25 27 27 "28 26 27 27 27 28 28 28 28 31 29 30 28 27 28 30 28 29 31 26 24 26 32 35 36 35 35 33
29 29 29 28 29 28 29 29 29 24 22 25 29 28 30 29 31 31 30 30 31 28 27 26 29 28 29 30 29 27 33 33 32 26 21 26 30 29 28 31 31 31 30 30 31 31 32 32
4
32 33 30 32 31 39 30 26 31 31 28 31 32 33 30 30 30 35 33 35 29 33 32 31 33 34 32 28 29 29 27 31 32 37 32
CMA 001856
jtiduaU/uM, O I U I C 2 I XaJjoaal&ueA, J*tc.
22
Group Sex and Species
Control F emale Mice
TABLE III continued h 5^*55 ^
""`l Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Animal Number
0
Individual Body Weights (grams)
Week Number: 123
4
936 937 938 939 940 941 942 943 944 945 946 947 948
949 950 951 952 953 954 _ 955 956 957 958 959 960 961 962 963 964 965 966 967 968 969 970
29 32 31 29 30 30 31 29 29 30 28 28 27 27 29 30 31 28 29 31 30 32 33 33 33 32 32 29 30 33 27 27 27 27 29 28 28 27 27 33 29 29 28 29 29 25 28 30 30 32 30 26 26 25 28 25 23 25 26 27 27 26 26 27 27 28 28 27 29 30 28 28 29 29 30 28 28 28 30 30 32 32 31 32 34 35 34 33 35 35 33 32 31 31 30 30 30 30 30 30 28 28 29 31 30 30 35 29 29 31 30 29 30 32 31 30 31 33 31 32 31 32 33 31 32 32 33 35 35 34 34 28 34 30 33 30 33 30 34 32 31 30 29 29 37 34 34 35 38 37 32 31 31 32 34 26 28 27 27 29 27 29 32 31 31 30 31 28 27 28 28 30 30 32 33
CMA 001857
IJnekubiial B I O * T E S T JLaluyiatarU&i, 9*tc.
23
CONFIDENTIAL
Subject to Protective Order in P-Q55 v- Conoco, Inc., Uo. 90-4837 TABLE III continued 14th Judicial District Court
Calcasieu Parish, Louisiana TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
* Animal Number
0
Individual Body Weights (grams)
Week Number: 123
4
Control
971
27 29 28 28 31
Female
972
29 28 29 27 28
Mice
973 31 33 34 34 39 974 25 29 31 30 33
975 28 26 27 26 29 976 26 28 31 . 29 33 977 28 29 32 32 29 978 29 30 28 32 34
979 26 27 30 30 30
980 27 30 32 34 29
981 29 28 28 29 29
982 27 32 34 34 35
983 29 30 24 42 35
984 .
31
31
32
31 32
985 27 27 27 32 33
986 27 27 31 28 28
987 29 31 28 28 29
988 25 28 31 31 29
989 30 29 28 30 32
-990
28 28 27 28 29
991 30 30 29 31 32
992
28
29
34
32,. .
34
993 28 32 29 43 43
994 30 31 33 33 35
995 32 34 36 37 36
996 29 29 31 30 34
997 28 27 24 34 31
998 29 31 34 25 38
999 1000
29 29 31 35 27 27 29 31 33 32
Mean
29 29 29 30 32
CMA 001858
9ndu&tual B I O - T E 5 T 2alto*at&ued., 9c.
24 confidb:;?!^ l
Sufejsct "to Protective Order in Ross v. Conoco, Inc., no. 00-4837
TABLE III continued
14th JudiciaT~District Court
Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Individual Body Weights
Group
(grams)
Sex and
Animal
Week Number:
SpeciesN umb e r01234
Control Male Hamsters
1601 1602 1603 1604 1605 1606 1607 1608 1609 1610 1611 1612 1613 1614 1615 1616 1617 1618 1619 * 1620 1621 1622 1623 1624 1625 1626 1627 1628 1629 1630 1631 1632 1633 1634
1635
87 105 84 98 82 98 74 83 76 86 73 91 75 87 80 84 84 85 73 82 78 78 71 92 78 87 80 91 72 82 87 96 81 68 58 79 54 78 63 76 75 80 78 71 72 78 84 64 91 57 60 54 77 64 80 65 58 77 92 60 75 68 76 77 83 86 92
45 57
117 123 126 106 112 116 111 120 115
94 101 102 99 110 104 107 118 112 101 107 70 99 108 108 86 91 89 104 117 113 88 95 101 104 115 116 102 112 86 103 112 104 92 100 94 106 113 114
- --
69 81 87 65 80 87 72 91 89 93 108 106 101 122 117 94 111 112 107 121 118 112 126 123 88 107 94 93 104 98 99 111 111 77 93 85 103 115 116 89 97 96 88 94 90 94 101 100 105 115 112 77 89 86
CMA 001859
yndM^uai tt l O - T E S T laboMtf&uei, Stic.
25
TABLE III continued
COHFISgTTTIAT.
i^ubJec^t Protective Order in
Ross v. C
_inc. , ilo. SO-4837
14',h Judicial District Court
TEST MATERIAL: Vinyl Chloride (EthyleneLouisiana
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
Control Male Hamsters
Animal Number
1636 1637 1638 1639 1640 1641 1642 1643 1644 1645 1646 1647 1648 1649 1650 1651 1652 1653 1654 . 1655 1656 1657 1658 1659 1660 1661 1662 1663 1664 1665 1666 1667 1668 1669 1670
0
77 98 82 80 103 27 47 47 88 86 85 67 93 79 72 79 62 57 75 79 84 76 76 70 81 70 75 75 72 66 68 67 79 75 52
Individual Body Weights (grams)
Week Numb er: 1 23
75 91 96 88 96 101 72 80 74 75 79 91 72 72 83 44 58 87 51 59 78 61 67 85 71 81 99 93 104 112 89 103 105 77 92 103 102 117 129 75 87 103 80 95 102 80 91 97 64 83 98 65 96 96 73 85 99 89 102 115
---
92 102 112
89 98 io9
- --
77 89 104 49 73 85 70 78 86 71 74 82 72 78 97
49 -
-
55 56 71
75 -
-
85 97 112
57 71 93
57 76 94
4
99 108
83 87 87 91 79 94 99 115 102 105 126 105 104 97 98 95 99 116
-
108 109
_
98 93 92 88 96
-
77
-
110 88 90
CMA 001860
jnsuttua+cu* u i w * i cj jLOM^auyueA, Jfic.
26
Group Sex and Species
Control Male Hamsters
Subject to Pro tec tivs Drier in
TABLE III continued
Boss v. Conoco. i4tn JTu,,*diricniatl
IDr'"is'ytr-il1c'"o't".
CCOo-u4'ri,3t; 37
Calcasieu Parish, Louisiana TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Animal Number
0
Individual Body Weights (grams)
Week Number: 1 23
4
1671 1672 1673 1674 1675 1676 1677 1678
1679 1680 1681 1682 1683 1684 1685 1686 1687 1688 1689 1690 1691 1692 1693 1694 1695 1696 1697 1698
1699 1700 Mean
83 72 80 76 68 64 64 75 80 98 77 81
79 75 74 79 71 48 72 44 42 73 66 82 44 68 78
79 79 74 73
80 88 102 104 73 90 104 98 51 54 67 76 51 55 71 75 51 56 70 77 49 59 74 76 50 57 81 87 52 48 52 58 82 87 109 108 93 88 105 99 77 80 95 96 79 89 102 101 78 101 106 105 75 89 101 103 74 88 100 94 79 92 107 94 68 78 87 85 56 67 83 89 70 83 98 97 56 73 96 95 47 63 90 88 62 79 102 96 69 81 112 115 80 95 112 113 47 68 88 92 66 79 81 87 60 80 105 102 70 93 110 104 77 89 104 98 66 64 73 77 74 86 99 98
CMA 001861
DudHAt/ual B 1 O - T E S T Xal&ud&uM, !)*tc.
27
Group Sex and Species
Control F emale Hamsters
Subject to Protective Order in
Ross v. Conoco, Inc. . '~n cc./io^i
TABLE III continued 24th J^dlJilTDilmct Court
Calcasieu Parish, Louisiana TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Animal Number
1701 1702 1703 1704 1705 1706 1707 1708 1709 1710 1711 1712 1713 1714 1715 1716 1717 1718 1719 ` 1720 1721 1722 1723 1724 1725 1726 1727 1728 1729 1730 1731 1732 1733 1734 1735
--
0
82 83 61 68 74 73 100 89 76 82 72 69 67 82 62 69 75 84 73 76 83 83 71 68 76 76 73 70 84 88 83 88 65 78 82
Individual Body Weights (grams)
Week Number: 1 23
74 72 75
80 80 86
71 68 73
63 67 70
81 91 101
95 106 117
49 81 92
48 82 91
56 73 83
81 92 105
69 77 81
- --
65 74 85
82 89 93
65 81 99
66 75 84
76 85 94
83 80 93
74 82 98
81 88 94
91 109 120
81 103 119
93 103 109 83 94 107
87 106 115
89 104 127
90 105 119
84 104 113
83 85 105
79 87
83 99 95 105
82 84 90
74 104 113
94 109 118
90 102 109
4
90 100
80 108 120 101 99 109 86 91 75 82 101 92 96 93 94 90 106 106 94 93 108 119 118 112 109 117 90 92 108 111 109
CMA 001862
^nduifoial B I O * T E S T Jahwafouet, !)'tie.
28
C0NFID5ZI?IAL Subject"-to Protective Order in
oss_v. Conoco, Inc.._Vn 90-4337 TABLE III continued
14th Judicial District Court Calcasieu Parish,, Louisiana TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
Control Female Hamsters
Animal Number
1736 1737 1738 1739 1740 1741 1742 1743 1744 1745 1746 1747 1748
1749 1750 1751 1752 1753 1754 ' 1755 1756 1757 1758 1759 1760 1761 1762 1763 1764 1765 1766 1767 1768 1769 1770
-t
0
77 72 74 74 70 73 70 78 82 82 79 85 65 56 71 78 82 75 70 78 79 90 75 86 80 77 71 75 81 71 66 66 74 82 76
Individual Body Weights (grams)
Week Number: 1 23
4
96 84 93 97
83 89 90 70
85 94 98 99
86 100 110 112
84 94 100 102
69 72 . 91 93
67 67 86 87
77 82 98 103
75 74 95 83
96 93 88 84
89
103
120
114
90 96 93 96
75 85 123 93
65 71 77 85
60 77 89 114
83 104 114 123
85
106
117
-
78 85 95 105
78 92 106 106
88 100 100 116
84 97 78 108
95 108 107 130
72 95 123 110
87 96 97 93
84 87 111 109
78 80 106 107
83 97 93 111
82 85 109 110
69 85 99 80
78 91 93 95
67 79 97 91
69 89 88 99
78 100
95 106
86 100 104 106
88 112 137 143
CMA 001863
SnituUiai B I O - T E S T lalwatafo&L, $nc,
29
C0NFIS31iTIAL
Subject to Protective Cr^er in Boss, v. Conoco, Inc,, Uo, DO-4837 TABLE III continued 14th Judicial District Court
Calcasieu Parish, Louisiana TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 1 23
4
Control
1771
110 110 112 122 138
F emale
1772
79 93 101 117 138
Hamsters
1773
77 82 91 99 114
1774
73 83 89 105 109
1775
88 88 104 121 125
1776
74 73 88 104 117
1777
75 81 93 97 108
1778
69 74 95 103 101
1779
72 76 111 108 120
1780
73 72 88 104 95
1781
80 90 88 121 100
1782
82 88 101 115 119
1783
101
91 103 121 101
1784
89 85 98 113 120
1785
88 91 104 108 112
1786
66 69 90 116 109
1787
78 83 101 113 123
1788
79 71 88 100 99
1789
76 76 78 90 96
1790
63 67 82 95 99
1791
81 83 96 107 103
1792 -1
69
76
92
106,
111
1793
80 82
-
--
1794
72 76 88 102 106
1795
69 87 88 103 119
1796
83 86 101 116 93
1797
79 65 77 122 120
1798
74 78 87 94 94
1799
59 88 108 89 89
1800
79 75 96 114 115
Mean
77
80
91 102 104
CMA 001864
Jtuludi'ual B I O * T E S T JtaluyiaityiiM, Unc.
30
C0l'T?iD~:-r^ t i
Subject to Frot^t; v ;'T,_ 1n
ggss v. Conoco, 7^., TABLE III continued 14th -Judicial
^ *J
Calcasieu Parish, r0UiS;,na
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
~JU-s^na
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 1 23
4
TE-I Male Rats
201 202 203 204 205 206 207 208
209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228
229 230 231 232 233 234 235
228 211 200 209 186 228 221 204 215 214
189 199 198 211 203 197 265 216 208 222 190 190 205 225 218 211 190 213 196 180 196 200 181 196 218
267 248 237 250 229 262 252 239 252 243 237 235 233 242 241 236 297 254 2 54 260 177 170 187 250 231
239 234 248 237 227 228 227 217 223 242
315 294 260 281 257 298 303 278 292 289 293 296 277 290 284
279 362 307 297 307 165 177 181 265 245 243 276 300 280 276 270 277 258 277 296
360 322 303 336 277 353 334 317 334 326 340 322 320 327 323 301 421 356 340 339 217 219 230 336 315 300 319 327 336 312 301 318 302 319 330
401 349 328 370 262 386 364 330 348 348 365 366 359 349 341 336 450 368 365 345 233 190 256 365 354 332 347 357 372 344 337 334
329 351
359
CMA 001865
OtuLti&uaL B I O - T E S T Jtakyioi&uei., One,
31 ^^'^COITFISg^TIAL .............
Subject to Protective Order in
Ross v. Conoco, Ir.c., Ko.
TABLE III continued
14th Judicial District Cpyrt
Calcasieu Parish, Louielane
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 123
.4
TE-I Male Rats
236 237 238
239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 2 54 - 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270
215 220 163 184 167 227 192 230 231 231
239 167 163 179 176
189 193 164 192 231
191 210 187 220 213 215
199 227 219 249 222 195 215 230 228
242 250 226 247 231 260 215 268 237 242 247 213 213 236 223 227 250 202 231 218 243 272 233 269 258 256 245 269 265 246 267 234
259 269 283
296
299 272 302 293 298 263 314 301 302 301 265 272 290 285 284 304 250 285 256 295 303 286 326 327 292 277 326 316 276 300
279 307 318 304
343 336 322 372 352 337 296 373 350 356 350 306 311 344 333 342 348 286 318 282 342 365 335 360 373 329 334 376 362 327 357 304
339 371 338
373 371 366 395 387 368 316 420 382 396 372 328 347
369 356 360 388 312 351 281 346 367 364 360 380 338 344 371 340 297 328 298 336 347 328
CMA 001866
Dttdmtuai B I O - T E S T labvuit&'UeA,
32 % ' v - coit?ih^:t t i a l
SuFJect to Protective Order In Boss v. Conoco, Inc. . o. CO-4037
TABLE III continued 14th Juilcial District Court p.1 Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
Animal _______ Number_______
Individual Body Weights (grams)
Week Number: 0123__4
TE-I Male Rats
271 272 273 274 275 276 277 278
279 280 281 282 283 284 285 286 287 288 . 289 290 291 292 293 294 295 296 297 298 299 300 Mean
222 204 245 238 252 240 226 228 213 222
239 197 210 210 231 202 211 217 188 213 201 188 197 215 213 205 204 198 222 228 209
252 231 295 270 315 283 268 264 256 268 285 245 254 248 273 244 246 258 220 252 249 225 242 257 252 253 249 242 274 280 246
271 249 313 303 322 327
299 294 315
239 283
279 299 295 248 302 275 286 253 296 331 257 285 292 290 334
289 280 290 317 286
321 368 300 306 365 315 338 338 396 400 353 359 303 311 329 320 313 323 352 358
327 372 373 322 331 337 340 355
340 349 328 332 362 341 329 311 289 280 335 349 342 351 305 303 324 329 319 313 344 353 328 341 331 340 326 337 365 389 368 392 331 346
CMA 001867
9aMut/ual B I O - T E S T J.al/&iabvue&, !)*.
33
CONFIDENTIAL Subject~l;o Protective Order in
^ ^Conoco, Ino.._ No. 90 - 4837
TABLE III continued
14th Judicial District Court
Calcasieu Parish Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 123
4
TE-I F emale Rats
301 302 303 304 305 306 307 308
309 310 311 312 313 314 315 316 317 318
319 - 320
321 322 323 324 325 326 327 328 329 330 331 332 333 334 335
172 166 145 164 165 152
159 167 181 144 149 152 182 179 157 156
159 155 153 185 186 178 172 181 167
149 145 157 150 152 131 124 126 118 156
188 186 156 197
191 184 176 174 192 196 171 174 190 170 178 181 188 172 167 206 191 190 191 185 177
169 167 176 172 160 160 161 151 151 167
207 202 176 226 216 213
199 198 234 226 201 212
219 189 212 218 202 203 207 251 212 216 213 202 212 195 192 212 199 190 190 187 177 183
189
229 220 184 255 226 218 226 241 217 245 215 228 240 209 217 230 214 220 217 253 229 230 229 213 236 217 212 232 222 217 209 201 198 204 211
248 252 196 267 243 233 225
251 223 234 213 225 254 244 221 244 225 230 235 253 241 231 254 224 251 224 226 242 234 229 218 225
209 217 205
CMA 001868
2*idu6il`uaL B I O * T E 5 T jtaitO'iai&u&L, 2*tc,
TABLE III continued
34 CONFIDEgTIAL
Subject to Protective Order In
"^llth'
' 50-4837
-TM Judicial District Court Cal^ieu Parish*
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 1 23
4
TE-I Female
Rats
336 337 338
339 340 341 342 343 344 345 346 347 348
349 350 351 352 353 354 . 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370
172 172 165 163 180 155 174 181 174 172 172 151 189 144 176 165 162 162 170 167 181 166 157 161 156 191 170 167 179 158 183 165 164 195 182
179 180 190 188 208 168 183 193 185 184 184 156 206 160 198 185 183 178 188 183 190 185 174 181 171 205 187 193 199 175 202 172 177 218 195
210 201 210 212 230 175 202 203 210 208
189 180 229 188 222 215 228 197 212 213 215 198 203 210 202 219 207 201 214
191 218 188 188 241 210
228 214 230 222 246
209 233 227 226
249 213 185 246 203 236 230 225 199 232 214 225 212 212 224 215 242 221 218 234
199 233 203 199 280 230
243 224 242 249 257 228 235 246 237 250 228 256 264 213 244
239 244 222 240
239 244 240 225 243 221 240 225 227 224 197 184 213 204 274 237
CMA 001869
Dnduitual B I O - T E S T J.aJfOAaiMie^.,
35
^"'"'"^'CQNFUENTTAL '
TABLE III continued
Subject to Protective Order in Ross v. Conoco, Inc..Iio. 90-4837
14th Judicial District Court
Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 123
4
TE-I F emale
Rats
371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398
399 400 Mean
178
191 178 174 177 173 183 163 183
159 170 186 161
169 153 182 185 175 176 177 177 211 204 161 166 155 196 198 180 156 168
206 206 190 198 195 184
199 180 192 168 186 180 171 190 162 198 201 213 184 190 182 223
189 176 186 185 205
209 190 174 184
207 230
209 217 212 212 213 217 215 190 202 196
191 202 175 203 220 233 196 215 202 245 198 204 207 200 220 222 208 190 207
225 242
219 241 226 224 226 230 236 203 223 218 202 216 182 219 232 253 206 225 213 2 64 217 203 220 215 230 241
219 201 223
217 248 233 261
229 228 231 217 240 208 225 240 204
219 192 216 218 265 226 243 224 268 232 176 235 192
239 233 252 207 232
CMA 001870
9ndiUi/UaL B I O - T E 5 T J-alwiatoAiei, 9*tc.
36
coitfissittial
Subject to Protective Oder TABLE III continued Ross^v. Conoco. Inc.. ;;n. 90-4337
14th Judicial District Courts Calcasieu Parish,. Louisiana TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 123
4
TE-I Male Mice
1001 1002 1003 1004 1005 1006 1007 1008 1009 1010 1011 1012 1013 1014 1015 1016 1017 1018 - 1019 1020 1021 _ 1022 1023 1024 1025 1026 1027 1028
1029 1030 1031 1032 1033 1034 1035
34 34 37 36 41 38 35 36 38 30 30 30 37 33 36 28
29 29 31 25 29 29 28 31 30 33 33 28 32 29 38 35 36 31 28
34 35 39 39 36 36 39 39 32 34 37 48 36 37 38 42 40 38 43 46 38 37 40 42 35 37 40 43 30 30 32 35 34 34 36 39 30 31 32 33 31 32 35 36 30 32 35 36 36 37 40 42 34 35 37 39 34 37 41 42 29 29 31 32 28 29 30 32 28 30 31 33 43 34 28 37 25 31 34 34 29 24 37 31 28 29 31 43 30 31 35 36 27 28 29 33 37 29 33 40 39 37 35 40 33 36 38 40 32 43 36 37 34 36 38 39 32 42 35 41 38 40 45 49 35 38 43 46 35 37 42 43 24 34 37 41 29 -30 33 35
CMA 001871
5*uLtdhiaL B I O T E S T lolwialiyU&i, D*tc.
37
C OflFIDSITT IAL'....^.....
TABLE
III continued
Sublet to Protactive Order in Reg V. Conoco, Jnc^ Ho. 30-4337
14th iulisial District Court Caloaaiou Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
TE-I Male Mice
Animal Number
1036 1037 1038 1039 1040 1041 1042 1043 1044 1045 1046 1047 1048 1049 1050 1051 1052 1053 1054 1055 1056 1057 1058 1059 1060 1061 1062 1063 1064 1065 1066 1067 1068 1069 1070
0
29 36 30 29 28 29 27 32 26 25 30 28 30 26 33 34 34 34 27 33 31 31 35 35 33 35 37 28 32 34 36 37 36 38 33
Individual Body Weights (grams)
Week Number: 1 23
31 33 42 34 35 36 33 37 38 32 33 34 31 46 44 35 34 36 28 30 31 27 29 32 28 30 31 31 34 35 32 30 34 30 31 33 31 32 35 29 31 36 34 34 40 34 33 38 35 34 35 35 31 30 29 29 35 33 35 39 31 31 34 35 37 40 30 35 39 32 32 34 34 35 39 34 39 35 39 39 40 39 42 43 32 31 33 32 37 42 34 39 37 35 40 41 35 39 41 35 39 40 26 28 31
4
42 38 39 36 44 38 36 35 33 38 37 36 37 38 40 38 36 32 42 40 38 41 31 40 41 44 42 44 36 37 42 42 42 43 32
U
001872
JnduitiuaL BIO'TEST ^abyia&yu&i,
38
C02T7IDS2TTIAL
Subject to Protective Order in Boss r. Conoco. Inc.. No. S0-4S37
TABLE III continued
14th Judicial District Court Calcasieu Parish,. Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 123
4
TE-I Male Mice
1071
33 31 35 37 38
1072
33 30 36 37 38
1073
37 37 38 40 41
1074
40 41 41 42 40
1075
38 40 40 43 43
1076
36 38 37 37 37
1077
35 36 38 45 39
1078
33 35 37 38 37
1079
35 36 36 37 40
1080
33 39 39 40 40
1081
37 37 38 38 41
1082
37 38 34 41 36
1083
31 34 38 35 41
1084
34 35 35 35 36
1085
33 34 35 39 39
1086
37 36 36 38 43
1087
30 36 37 40 39
1088
37 37 38 41 37
1089
33 33 33 33 44
1090
36 36 37 39 33
1091
34 35 35 37 38
1092 ~
37
39
37
39 44
1093
36 39 38 40 23
1094
32 38 39 41 39
1095
38 34 34 33 40
1096
34 35 41 38 36
1097
38 41 34 39 44
1098
36 37 36 38 39
1099 1100
33 34 39 35 37
40 41
39 45 42
Mean 33 34 35 37 39
CMA 001873
9*tduifrUal B I O - T E S T
9kc.
39
.CONFIDENTIAL
Subject to Protective c-d*r in
3*222. Conoco, rnc,
' ~0
TABLE HI continued
14th JudiciarDm^iC't Court"0
Calcasieu Parish, Louisiana TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 123
4
TE-I Female Mice
1101
30 29 32 31 32
1102
31 29 33 28 33
1103
29 27 30 30 30
1104
29 30 33 33 31
1105
32 25 30 32 33
1106
30 27 28 31 33
1107
30 25 26 29 30
1108
27 25 28 30 30
1109
30 29 31 30 34
1110
28 27 29 30 30
1111
29 27 31 29 30
1112
24 23 29 32 29
1113
29 28 30 30 30
1114
25 24 28 29 29
1115
33 31 33 33 29
1116
31 31 29 35 36
1117
31 32 34 29 31
1118
33 28 31 31 31
1119
27 26 29 27 30
1120
27 30 34 34 36
1121 .
33
27
31
31 32
1122
24 23 26 25 26
1123
28 27 29 30 34
1124
31 30 33 32 34
1125
27 25 27 27 30
1126
31 29 31 32 33
1127
28 28 31 32 32
1128
29 26 29 32 32
1129
31 29 33 33 33
1130
33 29 32 33 32
1131
30 27 30 31 32
1132
26 27 29 29 29
1133
28 24 27 28 28
1.134
27 30 28 33 31
1135
31 29 32 31 34
001874
D*tdu&t/ual B I O T E S T 2al&iaioAie4.t 9*tc.
40 COSFIDZffTIAL
Subject to Protecrire Order In ?03?- v* -?cncco, Inc,, :<~o. 90-4837
TABLE III continued
14th Judicial District Court Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
TE-I F emale
Mice
Animal Number
1136 1137 1138 1139 1140 1141 1142 1143 1144 1145 1146 1147 1148 1149 1150 1151 1152 1153 1154 1155 1156 1157 1158 1159 1160 1161 1162 1163 1164 1165 1166 1167 1168 1169 1170
0
31 29 30 36 33 33 29 31 33 32 30 31 29 31 30 30 31 26 31 29 30 32 31 32 32 31 31 29 29 33 29 28 33 28 28
Individual Body Weights (grams)
Week Number: 123
'4
26 33 30 34 28 30 31 20 29 33 34 33 36 38 42 40 33 37 35 39 28 33 32 35 31 32 30 31 28 34 34 35 31 33 34 35 28 32 32 31 27 33 33 37 30 33 31 33 28 32 32 31 28 33 32 35 28 31 30 34 27 30 30 33 31 34 36 35 25 27 27 30 30 33 32 37 29 31 29 30 34 37 36 36 31 34 32 28 30 34 33 35 29 32 32 32 29 32 33 33 30 32 33 33 30 32 34 33 28 31 31 33 28 32 35 33 29 33 35 35 32 35 36 37 29 32 32 32 29 32 33 33 27 29 30 31 28 29 31 33
CMA 001875
Dndurihial B I O - T E S T lahviai&tiei., Hue.
41
......." C0IT?ID5!TTIAL
Subject to Protectiva Ord?r in Boss V. ^Conoco, Inc. , Do. 90-4957
TABLE III continued
14th Judicial District Court Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 1 23
`4
TE-I Female Mice
1171 1172 1173 1174 1175 1176 1177 1178 1179 1180 1181 1182 1183 1184 1185 1186 1187 1188 1189 1190 1191 1192 TM 1193 1194 1195 1196 1197 1198
1199 1200 Mean
32 27 27 34 34 28 33 31 32 30 27 28 30 36 30 31 25 25 26
29 31 30 26 27 31 29 26
29 33 29 30
26 28 30 31 32 34 29 38 29 41 27 28
29 29 34 36 31 26 30 30 29 30 29 30 31 32 35 36 32 35 32 32
29 29 26 .25 27 27 28 30 30 32 24 30 30 25 27 29 34 34 28 29 33 33 30 29 26 26 30 30 29 31
29 32 31 33 33 39 32 30 30 34 32 31 32 31 36 36 28 32 31 28 30 32 32 30 32 31 36 36 34 32 34 33 30 32 26 26 28 32 31 29 32 35 32 34 25 28 27 28 35 36 31 32 33 36 31 32 29 33 31 34 31 34
CMA 001876
9nd*tifrual B I O - T E S T laltMoltyuei, Hetc.
42
CONFIDENTIAL
Subject to Protective Order In jtesS- v. Conoco, Inc., Co , 90 - 4307
TABLE III continued
14th Judicial District Court Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
TE-I Male Hamsters
Animal N umb e r
1801 1802 1803 1804 1805 1806 1807 1808 1809 1810 1811 1812 1813 1814 1815 1816 1817 1818 1819 1820 1821 1822 ' 1823 1824 1825 1826 1827 1828 1829 1830 1831 1832 1833 1834 1835
0
72 81 75 72 79 73 73 80 78 58 83 87 64 68 65
89 79 76 75 64 83 81 72 37 77 68 77 79 71 38 85 90 80 77 85
Individual Body Weights (grams)
Week Number: 1 23
'
81 105 118 75 86 95 91 87 100 82 95 105 87 94 103 88 95 99 75 84 96 85 88 96 71 84 102 50 66 81 90 91 91 94 102 108 89 81 93 59 72 81 63 71 82 88 101 114 77 86 102 80 89 101 89 96 106 70 79 89 84 83 104 93 89 106 80 77 88 60 67 85 78 77 68 72 70 80 75 76 65 73 75 83 72 84 93 47 62 80 88 100 100 89 100 113 73 88 99 84 91 95 90 99 104
4
112 96 96
103 88 89 93 87
102 82 84
109 93 78 81
119 109 108 107 100 116 107
91 95 63 88 54 89 96 81 102 120 107 92 96
U
001877
Swluihiai B I O - T E 5 T 2alto^alyue^, !)*
43
''" " C0NFID52TTIAL
Subject to Protective Croar in Ross_v. Ccnoco, Inc..Do. 90-4837 TABLE III continued 14th Judicial District Court
Calcasieu Parish,. Louisiana TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
TE-I Male Hamsters
Animal Number
1836 1837 1838 1839 1840 1841 1842 1843 1844 1845 1846 1847 1848 1849 1850 1851 1852 1853 1854 1855 1856 1857 1858 1859 1860 1861 1862 1863 1864 1865 1866 1867 1868 1869 1870
0
60 82 77 86 63 80 72 80 77 72 43 70 71 37 94 68 83 80 68 65 72 83 72 37 82 68 82 36 83 71 75 72 67 73 40
Individual Body Weights (grams)
Week Number: 1 2 3 !.
4
69 78 88 99 93 107 123 118 84 93 106 107 91 105 121 125
- -_ -
89 103 114 110
91 104 115 111
85 93 103 105
76 -
--
77 72 89 80
61 72 80 86
77 77 92 100
78 79 91 96
60 62 71 64
75 79 94 93
62 69 77 73
71 76 83 85
73 78 85 84
80 84 94 95
53 61 71 74
78 89 101 98
59 73 83 86
54 64 77 78
37 50 62 66
71 73 76 83
58 67 71 77
73 77 80 80
48 55 58 60
63 78 91 92
64 74 81 83
63 68 77 76
67 74 81 87
70 76 83 85
83 89 101 102 53 65 80 81
cm O O IB'78
!)rtdt4itiial B I O - T E 5 T ^ahaAaio'U&L, 9*tc.
44
CONFIDENTIAL
Subject to Protective Cr'ler in
Boss v. Conoco, Inc., No. 50-4337
TABLE III continued
14th Judicial District Court
Calcasieu Parish, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 1 2 3-
4
TE-I Male Hamsters
1871 1872 1873 1874 1875 1876 1877 1878
1879 1880 1881 1882 1883 1884 1885 1886 1887 1888 ` 1889 1890 1891 TM 1892 1893 1894 1895 1896 1897 1898
1899 1900 Mean
34 72 73 70 38 37 71 77 76 28 84 81 88 42 83 75 85 24
69 95 41 81 68 74
91 69 71 73 72 77 71
40 63 61 47 54 55 65 67 54 45 82 73 84 70
79 73 86 70 64 75 40 80
79 63 81 52 73 76 74 60 72
71 47 65
59 74 67 60 56 57 90 82 87 81 86 80 96 73 74 64 53 84 85 75 92 60 76 73 72 57 63
79
100 58 74
-
74 73 76 91 71 66 98 89 95 89 91 89 102 84 80 84 71 92 94 82 81 96 82 86 82 66 89
100 68 75
-
72
-
79 91 73 67 101 102 89 83 88 88 100 85 81 87 67 84 95 85 99 79 79 91 84 71 90
CMA 0187q
^Hduitual B I O - T E S T lalt&uU&iiei,
TABLE III continued
45 COITFIDSi-iZIAI,
Subject "to protective 0"*:lep in jfa33 v Conoco, Inc.. No. 90-4337
14th Judicial District Court Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 1 23
.4
TE-I Female Hamsters
1901 1902 1903 1904 1905 1906 1907 1908
1909 1910 1911 1912 1913 1914 1915 1916 1917 1918
1919 1920
1921 1922 1923 1924 1925 1926 1927 1928
1929 1930 1931 1932 1933 1934 1935
94 91 97 103 114 89 83 90 93 107 76 85 92 97 105 88 66 69 75 84 84 71 74 81 91 73 74 74 77 80 85 80 84 84 92 83 70 76 77 50 73 81 87 107 110 85 82 95 112 116 79 97 107 117 119 77 72 91 104 110 86 92 63 70 82 70 73 70 69 84 80 83 67 79 84 87 92 71 88 100 77 67 74 88 100 70 62 66 79 86 86 78 82 78 90 70 59 67 68 78 79 82 95 103 103 69 64 75 89 91 90 82 83 114 114 88 79 96 110 117 87 96 109 125 101 87 90 106 124 113 71 70 84 95 92 82 72 82 99 102 80 103 116 129 110 71 81 87 99 111 81 70 83 101 88 81 94 108 124 120 82 76 90 102 111 64 68 81 97 100 62 86 99 117 111
CMA 001880
^tuLuUuai B I O - T E S T lalma&vuei, 9*c.
4
CONFIDENTIAL
Subject to Protective Or.-'o'' in Boss v, Conoco, Inc,, iio. S0-4GC7
TABLE III continued
14th Judicial Bistrict Court Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
TE-I Female Hamsters
Animal Number
1936 1937 1938 1939 1940 1941 1942 1943 1944 1945 1946 1947 1948 1949 1950 1951 1952 1953 1954 1955 1956 1957 =-- 1958 1959 I960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970
0
64 79 81 73 83 55 75 62 73 73 67 80 81 77 61 83 71 81 98 94 70 87 78 79 79 93 85 62 80 67 76 48 69 53 55
Individual Body Weights (grams)
Week Number: 1 2 3'
`4
86 76 87 85
80 95 109 100
82 92 105 100
83 91 112 no
92 105 122 113
69 50 51 68
75 64 67 70
80 81 77 79
85 85 77 87
73 68 90 96
68 78 90 89
80 81 87 82
80 90 97 100
83 74 92 77
43 82 86 76
74 88 98 96
80 91 100 91
72 81 97 92
89 97 109 110
89 105 119 109
71 78 91 83
95 88 104 89
72 87 104 102
77 88 105 100
76 85 105 96
82 94 108 95
88 100 120 106
53 69 83 68
78 87 95 76
62 70 81 95
75 82 103 89
80 82 48 -
80 63 90 83
72 52 73 68
64 .63
76 66
CMA 001881
B I O - T E S T J.a&&talvu&i, 9hc,
47
coufids::
TABLE III continued
Subject to Protect .re 0:ier in Ross v. Conoco, jn-> , lio. SO-4837
14th Judicial District Court
Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 123
'4
TE-I F emale Hamsters
1971 1972 1973 1974 1975 1976 1977 1978
1979 1980 1981 1982 1993 1984 1985 1986 1987 1988 1989 1990
1991 1992 ~~ 1993 1994 1995 1996 1997 1998 1999 2000 Mean
94
79 85 81 94
79 71 92 56 80 83
79 74 91 87 73 77 96 92 81 76 83 77 84 93 79 85 90 77 88 78
82 90 106 100
90 101 110 98
86 86 99 100
79 -
--
87 102 116 118
76 76 89 87
76 81 96 83
88 100 121 103
60 69 77 73 80 85 94 86
77 90 105 103
68 77 87 84
74 89 102 97 89 98 111 105 84 81 82 99
70 67 102 69 71 73 86 72
83 103 111 98
86 96 106 105
72 88 100 105
53 68 81 68
78 96 111 111
72 86 99 82
82 96
--
93 110 123 112
78 87 99 95 82 97 106 90
89 108 124 11 2 76 95 103 106
83 95 104 99
78 85 96 95
CMA 001882
!)ndMdlwd B I O - T E S T AoJio^aiawi, 9*tc.
4g
CONFID^TIAI
Subject to Protective Order \ Boss v. Conoco, Inc., No. PC-ii
TABLE III continued
14th Judicial District Court Calcasieu Parish, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
TE-II Male Rats
Animal Number
401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 -- 423 424 425 426 427 428 429 430 431 432 433 434 435
0
182 189 176 192 185 197 189 195 198 232 249 184 198 195 167 151 150 187 215 150 208 204 197 215 215 193 153 170 146 187 175 201 204 187 216
Individual Body Weights (grams)
Week Number: 1 23
-4
247
259 227 261 256 273 257 271 267 308 317 256 274 258 223 217 222 251 281 210 276 277 246 281 294 269 220 229 210 263 240 279 286 251
289
281 294 250 295 290 302 286 296 304 344 347 311 301 285 244 251 251 260 297 2 54 310 316 275 311 333 292 271 268 243 295 284 332 344 308 326
313 341 278 332 332 330 327 331 328 358 371 353 319 313 280 305 310 311 335 304 350 '350 296 332 368 335 309 288 272 336 318 366 375 339 367
331 353 278 358 353
349 348 363 352 382 394 376 352 332 342 340 355 311 370
349 341 360 381 327 361 371 359 342 319 303 369 351 396 415 366
CMA 001883
SneLukiaL B I O - T E S T 2a&wat&Ui, !}ac.
49
CONFIDENTIAL
Subject to Protective Order in Ecso^v. Conoco, T-ic. . Lp. GO -433 TABLE nr continued I4th Judicial District Court .... Calcasieu Parish,. LouisianaTEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
TE-II Male Ra ts
Animal Number
436 437 438
439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470
~~
0
213 252 182 179 218 206 204 217 185 208 208 166
191 188 207 209 192 200 198 215 221 200 223 212 198 239 229 204 214 202 204 198 215 188 205
Individual Body Weights (grams)
Week Number: 123
4
258 341 258 257 290 273 267 277 278
259 292 221 251 262 274 283
229 265 264 288 287 274 285 301 266 289 281 252 270 245 254 250 266 232 246
277
391 289 305 333 300 316 313 295 309 320 266 278 303 308 320 255 305 308 323 342 308 341 346 305 340 299 340
319 284 306 302 315 278 336
297 444 330 320 365 321 323 342
319 314 332 316 305 346 350 344 267 346 341 357 385 340 367 360 346 390 381 345
369 317 362 344 357 307 322
404 486 350 357 394 345 356 360 342 332 378 335 322 371 375 366 285 378 359 393 377 363 384 381 370 415 407 372 386 343 380 362 390 340 326
CMA 001884
!,laduillial B I O " T E 5 T
9*te.
50
CONFIDENTIAL
Subject to
1u
Ross v. Conoco. m:
00-1337
TABLE III continued
14th Judicial District Court
Calcasieu Parish, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
TE-II Male Rats
Animal Number
471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 . 489 490 491 492 *"
493 494 495 496 497 498 499 500 Mean
0
208 221 237 207 219 204 227 210 229 207 204 213 240 208 203 208 204 192 210 213 202 214 204 189 201 208 161 209 191 207 201
Individual Body Weights (grams)
Week Number: 123
258 275 292 252 258 259 277 266 277 252 260 268
291 262 256 254 252 246 257 258 257 264
249 232 253 217 261 206 241 269 261
295 314 303 287
289 310 321 302 320 288 302 315 334 296 305 295 301 291 291 286
299 321 291 271
299 261 303 24 6 285 317 301
329 343 377 336 332 353 367 337 353 361 316 352 366 338 341 331 330 321 314 313 350 ^48 325 312 324 295 336 271 307 355 335
'4
352 337 382 379 360 397 272 375 387 343 387 387 407 316 299 365 359 355 356 330 373 385 359 344 369 350 381 312 334 393 360
CMA 001885
jWWwz/ B I O - T E S T laJ&natiyuei, Hxc.
TABLEj III continued
51 ccmyisziiriAi
Subject to Protective Crr'er in Ross v. Conoco, Inc.. do . 00 - 1337
14th Judicial district Court Calcasieu Parish, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 123
-
4
TE-II F emale
Rats
501 502 503 504 505 506 507 508
509 510 511 512 513 514 515 516 517 518
519 520 521 522 523 524 525 526 527 528
529 530 531 532 533 534 535
*"*
168 163 156 177 183 158 178 164 185 165
179 166 164 172 137 182 167 172 152 182 184 175 181 180 186 150 154 178 171 152 146 162 152 160 188
195 187 180 179 199 178 216 187 213 194 211 185 207 206 185 213 203 202 187 214
209 209 216 203 200 215 178 211 193 172 174 185 182 170 185
195 219 203 224 , 225 194 200 200 200 203 227
199 216 201 203 213 231 176 194 198 223 233 176 216 205 194 195 177 214 170 194 193 185
189 2 21
227 215 244 224
239 224 243 213 235 225 237 226 241 220 220 236
239 234 231 272 226 243 240 240
219 238 199 241 238 190 206 201 205 214 213
238 227 241 242 247 235 276 246 268 242 246 234 252 244 232 261 252 252 238
289 258 248 255 257 223 254 231 257 253 218 211 213 218 218 220
001886
B I O - T E S T Aalxyiato.'U&i, 9*tc.
52
" C0KFIP33TTIAL
Subject to Protective Order in TABLE III continued Boss v. Conoco, Inc. , lio 90-4337
I4tb Judicial district Court TEST MATERIAL: Vinyl Chloride (EthylLouisiana
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Individual Body Weights
Group
(grams)
Sex and
Animal
Week Number:
SpeciesNumber0123__~ 4
TE-II Female
Rats
536 537 538 539 540 541 542 543 544 545 546 547 548 549 550 551 552 553 554 555 556 557 ~~ 558 559 560 561 562 563 564 565 566 567 568 569 570
164 183 172 173 164 166 187 174 180 153 171 168 177 158 155 155 168 169 188 168 182 182 180 181 186 181 158 181 163 179 173 163 173 146 186
231 223
199 210 193 197 220 186 215 188 220 207 218 190 177 189 206 208 223 193
209 217 206 216 214 221 181 183 190 212 200 195 203 186 220
186 212 222 196 180 216 205 217 243 202 204
189 229 199 212 211 203
191 160 205
239 223 232 206 204 234 194 156 206 225 210 195 216 194 240
248 271 232 236
229 228 245 196 247 221 240 230 210 217 204 230 240 234
189 220 246 253 237 241
229 252 207 203 216 243 229 204 224 207 253
268 273 242 253 248 247 261 262 270 248 262 249 269 243
219 235 247 252 238 239 267 273 240 251 251 269 216 220 242 248 235 201 282
199 271
001887
9*tdtuhiaL B I O - T E S T J.aJwurion*e. 9*tc.
53
CONFIDS^TIAL
TABLE III continued
Subject to Frote=tiv3_C:-dor in Hoss_v. Conoco, Inc,. To. CO-435
14th Judicial District Court Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
TE-II F emale
Rats
Animal Number
571 572 573 574 575 576 577 578 579 580 581 582 583 584 585 586 587 . 588 589 590 591 *"* 592 593 594 595 596 597 598 599 600 Mean
0
183 187 179 164 172 169 153 192 174 182 157 179 172 170 187 189 167 166 182 178 198 160 161 176 180 168 175 159 187 182 171
Individual Body Weights (grams)
Week Number: 123
207 208 217 181 206 198 176 194 227 203 187 164 198 202 212 215 196 190 199 200 224 180 183 202 198 210 194 195
219 208 200
229 219 230 195 222 211 188 204 243
209 200 215 212 212 227 221 206 198 225 222 225 190 194 217 220 215 213 207 242 215 208
249 227
239 207 - 233 218 201 221 262 238 218 227 221 221 234 238 218 213 226
229 241 201 209 225 233 232 223 218 263 227 228
4
274 241 258
219 247 229 213 235 283 253 232 237 244 236 260 240 224 226 241 231 249 202 223 237 242 259 230 242 272 237 242
CMA 001888
Snduit/ual B I O * T E S T J.ait&iatvu&i, 9*tc.
COMD^TIAL
54
Subject to Protective Order in Boss v. Conoco, Ir.s. , No- 90-4337
TABLE III continued 14th Judicial District Court Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
Animal Number
0
Ind ividual Body Weights (grams)
Week Number: 1 2 3'
4
TE-H Male Mice
1201 1202 1203 1204 1205 1206 1207 1208 1209 1210 1211 1212 1213 1214 1215 1216 1217 1218 - 1219 1220 1221 1222 1223 1224 1225 1226 1227 1228
1229 1230 1231 1232 1233 1234 1235
37 35 36 41 42 36 36 36 41 40 36 37 37 41 41 37 36 36 40 40 39 41 40 44 43 38 37 40 42 42 40 43 44 48 48 33 35 35 49 51 40 41 45 38 43 36 40 40 43 37 38 38 39 43 41 40 38 39 47 44 34 34 34 38 40 34 37 36 40 39 34 35 38 41 40 34 32 32 35 35 33 31 32 35 36 33 34 38 42 41 36 36 37 40 39 36 35 36 39 40 32 35 35 38 38 36 40 41 45 46 34 33 33 37 37 35 34 35 37 37 36 34 35 42 41 35 34 34 40 41 35 37 36 39 42 37 39 39 45 47 40 42 41 45 45 37 36 37 42 42 37 38 38 43 44 36 37 37 34 36 35 37 37 41 41 38 39 40 42 42 36 37 37 39 42 U
001889
!)nd(*itnial
BIO-TEST
J.aJvyuit&uei, !)*tc, TABLE III continued
55 ' CONFIDED IAI
Subject to Protective Order in Ross v. Conoco. Ins.. No. 50-483F
14th Judicial District Court Calcasieu Parish, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 1 23
4
TE-II
1236
38 37 37 41 38
Male
1237
36 35 35 40 40
Mice
1238
34 37 32 35 37
1239
38 38 38 36 46
1240
39 40 38 43 43
1241
45 46 44 50 37
1242
35 36 37 42 49
1243
35 36 35 40 41
1244
40 39 37 43 42
1245
38 37 37 41 40
1246
38 37 35 40 40
1247
41 40 39 44 43
1248
40 40 38 43 46
1249 1250
38 37 33 38 38 32 34 33 36 37
1251
33 41
38 43 44
1252
36 36 34 40 38
1253
35 36 34 39 40
- 1254
34 39 36 38 42
1255
36 35 37 35 39
1256-*
38
37
31
41 37
1257
25 38 36 41 42
1258
28 36 36 37 38
1259
26 33 35 42 39
1260
32 36 35 36 38
1261
42 41 41 42 44
1262 1263
37 37 37 39 39 37 38 39 43 42
1264
39 41 40 46 45
1265
36 37 35 39 39
1266 1267
32 29 30 28 29 36 38 37 41 37
1268
33 35 27 28 27
1269 1270
35 36 34 36 38 31 40 37 37 36
CMA 0 0 1 8 9 0
Undu^niaL B I O - T E S T jLoJt&iatoJuei', H*tc.
56
COflFIPSHTIAI> `
Subject to Protective Order in Boss v. Conoco. Inc., No. 90-4337 TABLE in continued 14th Judicial District Court
Calcasieu Parish, Louisiana TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 123
.4
TE-II
1271
28 35 34 40 36
Male
1272
29 36 34 40 36
Mice
1273
35 34 35 35 36
1274
35 36 36 35 41
1275
37 40 41 41 43
1276
38 34 34 35 37
1277
38 35 41 40 43
1278
36 37 37 37 39
1279
34 34 35 36 38
1280
36 36 35 36 36
1281
36 34 35 35 37
1282
38 38 40 39 41
1283 1284
39 40 39 39 42 37 37 36 38 41
1285
38 39 39 40 43
1286
40 38 38 39 41
1287
39 38 38 41 42
1288
37 38 37 35 37
1289
41 42 36 38 43
` 1290
36 36 42 42 40
1291
36 34 33 37 39
1292
41 42 44 45 48
1293
31 32 35 34 50
1294
36 36 38 41 36
1295
34 41 41 42 41
1296
40 35 34 35 44
1297
35 34 35 36 39
1298
40 39 40 41 40
1299
36 34 36 36 37
1300
40 41 40 36 41
Mean 36 37 37 40 40
CMA 001891
B I O * T E S T Ja/uyiaityued, 9*tc.
57
CONFIDENTIAL
Subject to Protective Or-^er in Ross v. Conoco, Inc., ifo. DO--ICC?
TABLE III continued 14th Judicial District Court C\L Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 1 23
4
TE-H Female
Mice
1301
30 29 29 30 31
1302
26 27 26 27 29
1303
28 30 31 31 31
1304
27 30 30 32 31
1305
29 30 29 32 30
1306
27 27 27 29 29
1307
27 27 28 30 30
1308
27 29 28 33 34
1309
28 28 31 30 29
1310
32 31 33 36 36
1311
25 30 29 32 32
1312
32 25 25 27 27
1313
28 28 27 29 30
1314
29 30 28 29 30
1315
32 31 31 33 34
1316
27 27 26 32 32
1317
30 30 30 29 29
1318
31 31 31 34 34
1319
28 28 27 29 32
1320
25 31 30 32 25
1321
30 28 27 28 29
1322 ^
33
24
30
33 33
1323
30 24 24 25 28
1324
30 30 25 31 32
1325
31 24 24 26 27
1326
25 29 31 32 31
1327
33 25 22 25 24
1328
29 29 32 33 34
1329 1330
28 28 28 29 29 30 29 29 30 31
1331
33 31 29 30 32
1332
29 27 23 27 27
1333
28 25 27 30 30
1334
31 28 30 30 32
1335
31 32 33 32 32
U
001892
jiuLuM/'uai b I U I CO I
alyu&i., Jrtc.
58
CONFIDENTIAL
TABLE HI continued
Subject to Protective Order in Boss.?. Ccnoco, Ir.c., lk>. 90-4837
I4th Judicial District Court Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 123
4
TE-H F emale
Mice
1336 1337
32 30 28 28 29 31 31 32 35 35
1338
28 30 29 31 33
1339
30 28 30 34 34
1340
26 27 27 27 28
1341
30 25 29 33 30
1342
25 25 26 28 32
1343
30 29 30 32 31
1344
28 32 33 33 33
1345
26 27 28 30 31
1346
30 32 31 31 34
1347
28 28 24 29 25
1348
28 28 30 32 32
1349
24 30 30 30 30
1350
23 29 28 33 30
1351
23 28 27 30 30
1352
29 27 29 29 28
1353
28 28 26 29 30
1354
31 32 32 34 34
1355
25 27 25 29 30
1356
23 27 27 29 29
135V
28
27
25
27 28
1358
24 27 27 29 30
1359
22 30 30 32 32
1360
21 24 22 27 28
1361
26 28 27 28 30
1362
27 30 30 31 34
1363 1364 1365 1366 1367
29
32
27
29 30
27 29 29 30 32
29 35 33 36 34
26 29 29 31 33
24 26 31 34 32
1368
30 30 29 30 27
1369 1370
24 30 29 32 33 27 25 26 35 31
D I U I C ) I Z<.W&uU&ued., jnc.
59
....... .. COflFIDSSTIAI.
TABLE III continued
Subject to Protective Crier in Eoss v. Conoco, Ir.c . , No . 90 - 4337
14th Judicial District Court Calcasieu Parish,, Louisiana
TEST MATERIAL; Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species TE-II F emale Mice
.
Animal Number
1371 1372 1373 1374 1375 1376 1377 1378 1379 1380 1381 1382 1383 1384 1385 1386 1387 1388 1389 1390 1391 1392 1393 ^ 1394 1395 1396 1397 1398 1399 1400 Mean
0
31 30 30 27 28 32 28 28 27 25 29 28 29 28 29 27 28 31 25 28 29 29 28 30 36 32 25 24 24 34 28
Individual Body Weights (grams)
Week Number: 1 23
29 28 28 *' 31 30 36 29 30 32 27 28 30 31 31 31 27 23 28 25 22 25 32 35 38 29 29 30 29 30 32 27 27 30 32 31 33 28 31 31 30 30 30 31 33 32 32 32 30 27 28 31 32 33 31 28 33 35 29 30 31 29 30 31 30 30 32 30 29 32 32 38 37 39 40 43 34 34 36 24 20 23 23 21 25 23 21 24 35 34 35 29 29 31
4
31 35 33 32 28 34 28 36 29 30 33 34 35 31
29 28 32 34 32 29 31 31 33 36 41 37 24 24 27 33 31
CMA 001894
J+uLuiiial B I O - T E S T lali&iai&UeS, 9*tc.
60
Subjaot~to ?rct33tiv-
-- -*n
Eoss V- Co--^ I.O.`90-4837
TABLE III continued
14th Judicial District Court Calcasieu Parish, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
TE-H Male Hamsters
Animal Number
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 ` 2020 2021 2022 2023 2024 2025 2026 2027 2028 2029 2030 2031 2032 2033 2034 2035
0
34 36 39 36 35 36 37 34 39 35 38 40 30 38 37 37 38 34 35 31 36 34 36 40 37 36 35 38 37 40 43 37 35 34 38
Individual Body Weights (grams)
Week Number: 1 23
.
4
46 63 74 81 42 53 59 66 55 73 90 99 52 72 88 97 45 62 86 90 50 70 94 118 41 61 79 86 46 56 78 80 47 63 72 78 48 65 73 80 45 61 83 91 46 71 87 96
39 59 80 84 45 62 86 90 41 61 79 83 49 71 84 88 45 56 67 75 46 63 71 79 51 72 88 92 39 59 70 77 51 73 89 90 46 62 80 87 49 71 87 91 46 56 78 86 41 61 79 85 50 70 86 93 48 65 76 83 45 62 70 81 43 59 72 78 43 54 67 74 48 64 75 82 41 59 69 75 45 60 71 78 46 63 85 92 53 68 78 82
CMA 001895
'JttdiutuaL B I Q * T E S T JiaJMAaXtvU&i,
61 C OITFIDSITTIAL
Subject to Protective Or^er in Boss v. Ccnoco, Ir.c. , No. 20-4337
TABLE III continued
14th Judicial district Court Calcasieu Parish,. Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
TE-II Male Hamsters
Animal N umb e r
2036 2037 2038 2039 2040 2041 2042 2043 2044 2045 2046 2047 2048 2049 2050 2051 2052 2053 2054 ` 2055 2056 205^ 2058 2059 2060 2061 2062 2063 2064 2065 2066 2067 2068 2069 2070
0
35 40 , 41 37 38 34 32 37 36 35 39 37 37 34
91 67 82 77 68 61 37 81 36 74 68 84 74 85 75 78 82 32 75 81 68
Individual Body Weights (grams)
Week Number: 123
47 45 50 41 45 46 47 49 42 50 58 50 48 51 80 62 77 64 55 74 49 67
-
72 83 72
-
82 67 68
-
-
85 81 64
58 62 70 61 56 63 63 66 57 62 82 72 65 72 86 70 90 71 60 87 60 60
83 92 78
-
87 80 79
-
-
96 87 75
66 69 86 77 63 74 70 68 85 70 91 81 74 79 100 78 100 80 68 91 82 , 57
95 106 83
91 92 93
-
-
107 97
103
4
72 77 90 81 69 81 76 75 93 78 98 87 82 83 107 85 103 88 74 102 90 64
-
102 113
91
-
102 87 87
-
-
98 98 99
001896
9ndiUiniaL B I O - T E S T laitmaimiU, 9nc.
62
COiTFITSITTI AI
Subject to Protective Order in Boss v, Conoco, Inc., to. 50-4537
TABLE III continued
14th Judicial District Court
Calcasieu Parish, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 123
.4
TE-II Male Hamsters
`
2071 2072 2073 2074 2075 2076 2077 2078 2079 2080 2081 2082 2083 2084 2085 2086 2087 2088
2089 - 2090
2091 2092 2093 2094 2095 2096 2097 2098 2099 2100 Mean
80 91 97 93 98 68 81 91 102 84 77 75 82 85 91 73 82 97 111 104 82 70 80 84 68 75 72 77 81 64 89 - - - 79 90 90 96 89 73 90 97 107 110 83 82 94 102 104 80 86 94 102 106 75 82 61 72 75 84 76 61 73 76 77 71 66 76 78 64 71 79 97 95 76 76 83 90 88 71 82 90 89 81 82 88 92 101 90 77 81 88 95 101 84 97 102 108 101 72 79 87 105 111 79 88 100 11.0 101 72 74 86 94 113 36 - - - -
85 94 102 109 no
62 64 72 81 72 77 92 108 111 92 100 108 117 121 73 80 88 98 99 82 78 82 62 73 63 61 82 83 89
CMA 001897
9*uLutual B I O - T E S T lalxyiaiwuM, Hoc,
63
CONFIDENTIAL
Subject to Protective Order in B0S3 v. Conoco, Inc., :;o. 30-4337
TAB LE III continued
14tb Judicial District Court
Calcasieu Parish, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group
Sex and
Animal
SpeciesNumber
Individual Body Weights (grams)
Week Number: ________ 01_234
TE-II F emale Hamsters
2101 2102 2103 2104 2105 2106 2107 2108
2109 2110 2111 2112 2113 2114 2115 2116 2117 2118
2119 2120 2121 2122 ^ 2123 2124 2125 2126 2127 2128 2129 2130 2131 2132 2133 2134 2135
75 74 71 82 76 66 66 75 83 77 72 57 75 77 72 71 74 86 107 68 75 65 76 63 73 80 73 66 64 64 62 81 74 77 82
76 76 96
- --
80 89 104 72 81 90 80 99 115 80 101 117 75 91 102 81 96 113 75 85 107 68 93 99 77 89 105 66 85 101 70 76 97 64 61 68 64 62 61 56 55 53 72 83 87 88 104 115 91 105 119 70 82 101 80 91 102 71 85 104 87 101 114 71 83 97 90 97 110 94 106 116 81 89 98 80 87 99 76 87 99 76 91 106 75 88 96 97 107 123 65 85 101 59 78 99 95 91 113
85
-
116 85
114 107 106 120
75 103 111
99 105
79 73 68 90 114 109 92 85 83 100 76 111 102 95 91 98 89 77 116 104 85 113
CMA 001898
!)rtdu4&iitiL B I O * T E S T JlahyiaiiyueA., Unc.
64 ' CONFIDIC^TXAL
TABLE III continued
Subject to Protective Cr^r in Boss v. Conoco, Inc. . --Q-
14tb Judicial ^isvn-o ^Ov-i-t Calcasieu Parish, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
TE-II F emale Hamsters
Animal Number
2136 2137 2138 2139 2140 2141 2142 2143 2144 2145 2146 2147 2148 2149 2150 2151 2152 2153 2154 ' 2155 2156 2157 * 2158 2159 2160 2161 2162 2163 2164 2165 2166 2167 2168 2169 2170
0
81 78 73 68 78 76 71 80 75 72 82 76 75 82 72 86 70 82 79 77 66 76 61 56 66 73 89 78 74 78 82 59 59 59 81
Individual Body Weights (grams)
Week Number: 1 23
-
4
74 99 76 85 86 96 72 88 79 88 85 90 79 84 85 98 88 101
79 79 55 91 76 74 76 72 83 75 68 58 89 78 72 77 80 84 84 95 88 . 94 63 69 89 98 83 93 75 85 87 98
78 89 75 85 74 87 56 47 80 58 74 47 72 65 67 79 62 94 93 96
110 102 115
97 103 101 102 120 120
77 78 81 85 94 56 84
89 99 102 80 61 93 108 101 107 112 106 98 53 56 78 83 91 81 117
100
-
112 94
-
93 102
97 110
78 105
83 80 86 71 88 95 104 108 97 78 110 106 97 91 104
95 92 55 77 58 75 90 83 109
001899
Jnduit'Ual B I O * T E S T la&cwzlyue/i, 9*tc.
TABLE III continued
65 C 0N71 !>- TIAL
Subject to Protective Cr'=r Ross v. Conoco, Inc., '.'e . SC" Lj j7
14th Judicial District court Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
TE-II F emale Hamsters
Animal Number
2171 2172 2173 2174 2175 2176 2177 2178 2179 2180 2181 2182 2183 2184 2185 2186 2187 2188 2189 - 2190 2191 2192 2193 2194 2195 2196 2197 2198 2199 2200 Mean
0
71 79 86 84 82 75 95 69 59 59 73 81 76 70 87 82 78 75 71 74 56 56 60 62 54 71 79 82 76 67 74
Individual Body Weights (grams)
Week Number: 123
73 59 105 71 77 92 78 72 93 64 69 90 68 70 90 76 85 96 90 103 109 74 81 90 60 74 91 65 75 85 60 76 86
- --
81 93 92 66 65 71 79 91 106 74 84 104 82 92 109 70 87 100 66 70 89 64 76 96 60 59 79 55 60 76 60 60 62 65 63 86 52 49 78 61 58 82 84 95 107 87 99 111 78 91 102 55 49 60 75 82 95
4
95 94 103 104 104 97 100 91 100 96 100
-
103 79
110 111 108 103
89 109
80 85
-
81 78 75 99 109 104 62 94
CMA 001900
Group Sex and
Species
TE-III Male Rats
hV I
66
CONFIDENTIAL
TABLE III continued
Subject to Protective Cr^er oss.v. Conoco, loo.. '3q-4317
14th Judicial District Court
Calcasieu Parish, Louts<nna TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Animal Number
601 602 603 604 605 6 06 607 608 609 610 611 612 613 614 615 616 617 618 619 620 .621 622 623 624
625 626 627 628 629 630 631 632 633 634 635
^
0
181 156 172 176 172 152 206 186 190 206 177 179 181 174 190 194 178 200 184 206 212 205 193 183 189 185 204 220 229 217 199 197 217 193 209
Individual Body Weights (grams)
Week Number: 123
238 214 223 222 227 197 256 231 236 254 220 232 243 227 246 245 243 246 239 258 260 250 244 246 235 242 252 273 249 266 244 239 263 237 256
317 271 296 312 284 260 342 2 90 303 299 299 305 317 299 311 310 290 310 314 314 288 307 299 308 308 302 328 334 360 340 312 294 322 298 310
343 .. 302
339 328 311
289 366 305 321 332
329 344 347 331 342
339 305 330 361 340 307 303 295 317 290
309 349 347 387 361 337 314 348 328 331
4
378 326 372 369 349 331 388 330 346 351 350 367 374 362 380 366 341 361 401 360 351 359 337 363 336 362 374 378 417 385 363 342 365 360 344
CMA 001901
Undtotual B I O - T E S T Jakyiaiytiei, 9*.
TABLE
III continued
c OHFIDENTIAL_67
Sub'ject to Protective "or^r i'
Boss v. Conoco, Ir.o. , ks- 93-43 14th Judicial District Court Calcasieu Parish, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
TE-UI Male Rats
Animal Number
636 637 638
639 640 641 642 643 644 645 646 647 648 649 650 651 652 653 654 655 656 657 658 ^ 659 660 661 662 663 664 665 666 667 668 669 670
0
204 196 195 203 193 215 201 192 219 199 220 221 190 162 155 169 150 177 176 212 211 188 192 227 201 200 183 198 194 179 201 216 227 208 242
Individual Body Weights (grams)
Week Number: 1 2 3
250
249 265 248 240 264 246 232 265 233 266 235 226 250 210 228 245 207 223 252 258 235 225 262 249 242 269 238 234 242 247 263 274 240 275
331 323 323 326 307 324 309 296 357 323 340 305 304 306 274
309 331 273 295 314 327 312 273 340 325 270 305 282 270 285 277 305 320 306 258
368 342 344 344
339 357 337 322 384 333 368 343 329 341 311 346 367 305 320
329 345 333 ' 306 367 360 297 337 311 299 320 303 334 358 363 288
4
369 374 363
369 374 381 347 341 4 05 352 387 359 368 362 338 379 423 344 357
349 333 368 342 392 303 328 341 331 329 326 340 352 361 343 331
CMA 001902
9nduihial B I O - T E S T labtoat&uei; Hue.
68 COUFIDElffTlAI.
Subject to Protective C-r^r 'n
Boss v. Conoco,
TABLE III continued
X4th Judicial Pistrio, ^ouCalcasieu Parish, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
TE-IU Male Rats
Animal Number
671 672 673 674 675 676 677 678 679 680 681 682 683 684 685 686 687 688 689 ` 690 691 692 ^ 693 694 695 696 697 698 699 700 Mean
0
221 191 227 205 232 217 218 200 185 218 217 243 236 201 213 217 218 208 200 211 177 213 199 208 224 206 196 212 205 217 200
Individual Body Weights (grams)
Week Number: 1 23
267 234 266 243 278 262 261 272 218 236 246 262 267 221 235
249 259 253 240 251 217 262 244 253 268 250 235 253
239 262 245
307 284 301 294 272 285 311 315 252 270
292 278 282 253 282 273 290 290 286 279 280 339 325 324 351 296 263 284 271 307 302
326 307
330 301 335 312 323 346 277 290 311 328 313 261 282 293 321 315 304 310 273 331 314 323 342 323 291 318 294 335 326
4
356 299 346 342 364 335 351 371 290 316 339 322 344 303 305 329 351 352 333 332 280 372 359 341 366 345 307 313 312 349 351
CMA 001903
SttdwU/ual B I O * T E S T J.aJvyieilfrti&ir 9*tc.
CONFIDENTIAL 69
TABLE III continued
Subject to Protective Order in Boss v. Conoco, Ire., Lr. SO-4337
14tb Judicial District Court Calcasieu Parish, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
TE-HI F emale Rats
Animal Number
701 702 703 704 705 706 707 708 709 710 711 712 713 714 715 716 717 718 719 - 720 721 722 ^ 723 724 725 726 727 728 729 730 731 732 733 734 735
0
155 197 168 171 153 197 171 168 179 175 144 182 173 156 163 149 184 170 149 160 153 159 147 171 185 152 167 181 178 180 166 174 165
169 154
Individual Body Weights (grams)
Week Number: 1 23
211 185 193 208 193 169 183 186 188
191 163 206 188 175
179 169 213 185 165 182 185 169 169 184 203
169 201 192 204 178 182 211 181 185 173
253 228 224 228
191 264 212
239 224 237 205 236 217 197 212 211 233 223 196
219 213 212 204
229 238 237 230 234 232 231 207 242 203 221 207
268 231 230
239 221 272 221 254 233 254 234 244 224 222 217 216 245 248 236
289 220 206 213 234 276 216 231 246 258 250 221 242 218 227
219
4
278 245 239 249 234 275 235 242 243 267 249 251 239 269 228 232 260 321 263 267 247 214 223 239 254 227 241 257 254 268 229 263 218 250 240
CMA 001904
y+idndtual BIO-TEST JLaJuyiaio'UeL, !)hc.
CO^IFIDS-TTIAIi 70
TABLE III continued
Subject to Protective Grier Ross v. Conoco, Inc., to - S C - '-33
14th Judicial Eistrict Court Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
Animal Number
0
Individual Body Weights (grams)
Week Number: 1 2 3-.
4
TE-III
736
175 195 222
F emale
737
156 173 201
Rats
738
175 203 241
739
182 198 225
740
196 211 243
741
154 172 211
742
168 175 210
743 166 182 215
744
168 181 226
745 173 179 205
746 164 185 219
747
167 185 217
748
162 179 203
749
101 200 242
750
171 188 223
751 141 165 193
752 148 157 198
753 754
152 180 213 165 187 227
` 755
171 187 221
756 161 179 210
757 'fc 149 161 193
758
170 190 222
759
172 189 223
760
164 185 222
761 167 183 225
762
186 206 235
763
175 199 217
764 189 204 205
765
146 170 202
766 156 188 217
767
146 151 185
768
139 172 202
769
148 174 210
770
171 190 219
239 215 250 240 255 215 211 224 242
209 225 227 218 251 226
209 206 230 229 225 217 206 228 236 238 208 252 233 239 210 223 198
209 223 228
244 227 266 261 264 238 223 223 248 221 242 242 224 280 240 222
219 253 253 241 229 218 245 251 250 213 270 250 250 236 248 222 226 243 239
CMA 001905
9*itLtiiual B I O - T E 5 T lalwaiiyued., 9*tc.
TABLE III continued
confidential71
Subject to Protective C""
Ross v. Conoco, It;
c
14th judlciiTsTstrlct Co
Calcasieu Parish,, Louis!
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
T E - III Female Rats
Animal Number
771 772 773 774 775 776 777 778 779 780 781 782 783 784 785 786 787 788 789 ` 790 791 792 ~ 793 794 795 796 797 798 799 800 Mean
0
178 167 177 186 170 161 179 169 164 149 141 174 155 182 168 144 152 175 151 192 160 161 155 162 149 162 173 155 161 168 165
Individual Body Weights (grams)
Week Number: 1 23
201
196 185 203 197
179 197 183 181 172 156 194
169 206 183 163 173 192 170 208 182 185 177 188 175 178 188 170 176 181 185
229 223 229 241 218 207 235 206 201 188 176 214 180 236 221 187 212 214 197 240 210 221 197 213 200 207 210 180 196 215 216
242 221 231 244 226 215 244 221 211 211 190 238 202 232 230 198 220 230 207 240 216 233 210 218 216 223 223 192 216 224 228
4
250 255 245 264 238 228 227 233 226 227
199 249 218 253 . 245 210
239 209 215 260 238 243 225 242
229 213 234 195 231 204 240
001906 CMA
9tub*U*ial BIO-TEST lalotafouel. 9*c.
CONFIDENTIAL"^
TABLE III continued
Subject to Protective Order in Ross v. Conoco, Inc., So, 90-4337
14th Judicial District Court ^ Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
TE-HI Male Mice
Animal Number
1401 1402 1403 1404 1405 1406 1407 1408 1409 1410 1411 1412 1413 1414 1415 1416 1417 1418 1419 - 1420 1421 1422M. 1423 1424 1425 1426 1427 1428 1429 1430 1431 1432 1433 1434 1-435
0
37 34 37 36 40 34 32 38 37 37 32 37 36 38 36 37 36 31 37 34 37 32 33 33 36 31 34 37 35 35 37 34 34 37 35
Individual Body Weights (grams)
Week Number: 123
29 31 39 33 34 36 29 28 35 37 37 41 37 40 44 35 34 37 31 30 34 39 34 38 37 36 38 30 33 35
30 30 33 30 32 36 31 33 36 31 33 35 33 34 37 38 37 38 36 36 38 32 33 35 38 38 40 36 37 39 36 36 38 32 33 36 32 28 33 34 30 35 35 36 34 31 34 39 34 35 39 37 38 40 36 38 39 36 38 41 38 37 39 34 34 37 35 36 38 39 36 40 36 36 39
4
40 36 35 40 44 37 34 39 38 36
34 40 34 34 36 36 37 35 39 39 40 35 33 31 32 35 39 39 40 40 37 39 40 39 37
CMA 001907
^nduitiial B I O - T E 5 T J.alta^aia^uei, 9*tC.
....... COHFIDSKTIAI
73
Subject to Protective Order in Boss v. Conoco, Inc., to . 90 - 4337
TABLE III continued 14th Judicial District Court Calcasieu Parish,, Louisiana,
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
TE-III Male Mice
Animal Number
1436 1437 1438
1439 1440 1441 1442 1443 1444 1445 1446 1447 1448 1449 1450 1451 1452 1453 1454 - 1455 1456 1457,. 1458
1459 1460 1461 1462 1463 1464 1465 1466 1467 1468 1469 1470
0
37 37 33 36 39 35 38 37 38 33 39 35 36 35 38 37 36 37 37 35 32 35 36 36 37 37 32 38 37 37 42 34 35 36 40
Individual Body Weights
(grams) Week Number: 123
37 37 42 36 36 40 32 32 35 33 32 36 39 39 40 34 35 36 33 32 35 38 38 41 38 39 42 34 34 34 31 31 33 35 36 38 36 37 42 35 37 41 36 37 43 32 32 35 35 37 38 35 38 40 34 36 38 34 36 40 32 34 39 33 33 38 37 37 40 37 37 36 38 38 42 36 36 42 31 31 34 31 32 37 40 39 41 38 39 41 44 43 47 35 31 36 33 35 37 35 36 38 40 38 43
4
40 39 36 38
39 38 41 42 41 31 34 25 41 41 . 42 36 37 37 40 40 41 43 37 36 40 44 34 37 41 40 .45 37 34 38 41
CMA 001908
^nduiluai BIO-TEST Jtahyua&vtiei, 9*tc.
` " "CONFID^^TTIAL 74
Subject to Protective Order in
Ro33 v. Conoco, Inc to 50-^857
14th Judicial District Court
TABLE HI continued
Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
TE-III Male Mice
Animal Number
1471 1472 1473 1474 1475 1476 1477 1478 1479 1480 1481 1482 1483 1484 1485 1486 1487 1488 * 1489 1490 149 1492 1493 1494 1495 1496 1497 1498 1499 1500 Mean
0
37 33 36 33 37 39 34 35 37 34 40 41 37 39 36 36 33 34 33 32
39 34 38 34 33 37 42 38 36 37 36
Individual Body Weights (grams)
Week Number: 1 2 3-.
4
36 38 41 43
33 33 34 36
37 34 37 37
33 32 37 45
36 32 35 45
40 32 39 41
34 34 39 ' 40
35 35 40 37
29 33 36 37
40 41 45 45
38 38 41 40
42 41 37 31
35 32 45 44
38 39 41 41
36 34 39 37
37 35 40 41
34 31 36 40
34 35 36 40
38 36 37 36
34 31 37 38
37 41 36 42
33 34 40 41
36 37 43 37
31
38
. 41
42
30 31 36 38
27 30 36 39
44 42 45 45
38 37 37 39
37 35 37 39
37 36 40 38
35 35 38 38
CMA 001909
DntLtditial B I O - T E S T Jtaluytat&tiei; 9*tc,
f COffFIP^IAL75
TABLE III continued
Subject to Protective Order in
--P^s 7- Conoco, lac. . Ho, 50-433' . i4tb Judicial Pi strict Court h Calcasieu Parish, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
TE-III F emale Mice
Animal Number
1501 1502 1503 1504 1505 1506 1507 1508 1509 1510 1511 1512 1513 1514 1515 1516 1517 1518 1519 1520 1521 1522^ 1523 1524 1525 1526 1527 1528 1529 1530 1531 1532 1533 1534 1535
0
28 28 28 28 25 26 28 26 25 30 25 27 34 25 32 29 27 26 29 31 30 26 28 30 29 27 32 27 26 30 28 27 25 27 33
Individual Body Weights (grams)
Week Number: 1 2 3 ..
30 22 31 32 28 32 29 29 36 33 25 32 27 28 30 27 25 33 26 28 29 29 20 27 30 32 33 28 27 29 25 26 29 32 27 31 26 22 26 25 20 24 32 30 38 25 24 29 26 27 28 26 27 27 25 21 25 32 30 34 30 28 31 25 20 / 27 28 26 29 29 29 32 28 27 30 32 32 34 25 25 35 28 22 27 26 25 26 30 32 35 30 26 30 27 22 25 23 32 28 27 28 27 23 27 31
4
33 33 29 32 35 27 28 29 35 29 30 31 28 25 . 36 31 30 29 26 34 30 30 30 33 32 35 32 26 27 35 29 28 30 28 33
CMA 001910
9ndudl?ual B I O - T E S T 2a&<viattvue4; 9*ic,
76
C0HFI3SNTIAL
Subject to Protective Grder in
TABLE III continued J5S_v. Conoco, xnc., IIo. 90-4837
14th Judicial District Court Calcasieu Parish, Louisiana TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
T E - III F emale Mice
Animal Number
1536 1537 1538 1539 1540 1541 1542 1543 1544 1545 1546 1547 1548 1549 1550 1551 1552 1553 1554 ` 1555 1556 1557 1558 1559 1560 1561 1562 1563 1564 1565 1566 1567 1568 1569 1570
0
28 27 30 28 30 32 26 29 29 27 24 28 30 28 31 26 29 27 28 27 26 30 26 28 31 32 28 34 29 29 33 30 31 26
29
Individual Body Weights
(grams) Week Number: 1 23
31 30 28 28 24 28 27 23 26 28 28 30 30 31 32 25 20 25 27 26 27 31 31 33 30 29 30 27 26 26 26 22 27 25 23 26 24 22 28 26 26 30 28 25 28 24 27 28 27 28 31 25 27 29 27 30 31 26 26 30 27 26 29 30 30 34 26 23 30 28 29 31 32 29 34 35 24 37 30 32 33 30 29 30 33 31 33 31 32 31 29 27 31 25 24 27 29 28 31 32 30 33
30 28 31
4
31 25 29 29 33 25 29 35 34 29 29 28 26 31 29 27 31 30 32 30 33 36 29 31 37 38 34 28 33 33 34 28 34 33 32
CMA 001911
9*udu<.Usual B I O - T E S T lakyuiioJueS, 9etc.
TABLE III continued
~ -- - ' *. . j
Subject to Frotec~t:73~d,ir in --0 S-s. 7- .Conoco, Inc.. An S0-4837 . 04th Judicial District Court 1`- Calcasieu Parish, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and
Species
TE-IH F emale Mice
Animal Number
1571 1572 1573 1574 1575 1576 1577 1578 1579 1580 1581 1582 1583 1584 1585 1586 1587 1588 1589 1590 1591 1592** 1593 1594 1595 1596 1597 1598 1599 1600 Mean
0
28 27 30 27 24 25 26 29 26 30 30 25 27 27 27 25 24 28 27 28 30 25 25 28 30 24 27 28 26 29 28
Individual Body Weights (grams)
Week Number: 123
30 30 33 27 29 32 30 20 30 26 22 26 25 29 25 25 29 25 26 31 25 31 32 42 26 22 26 30 31 26 31 32 28 25 27 25 28 30 24 27 29 30 27 28 30 24 27 30 23 26 23 30 32 28 28 30 25 29 32 28 31 32 27 24 23 26 24 24 28 30 31 32 32 34 34 26 29 33 28 28 31 28 29 31 27 29 30 29 30 30 28 27 30
4
34 33 31 29 26 27 26 25 28 27 26 27 42 32 33 32 27 31 26 28 30 27 38 35 36 37 33 33 33 32 31
CMA 001912
9mituinial BIO-TEST Jiabotalyiiei, 9*tc.
TABLE
III continued
IDS F?IAL78
Sttb'jiet frStlrtiVe Grdr In
la v ftsaaea, fes-- fa-
ut% Smma mm#
^/JBtlwslW ??A" fetttS&Sl
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
TE-III Male Hamsters
Animal Number
2201 2202 2203 2204 2205 2206 2207 2208 2209 2210 2211 2212 2213 2214 2215 2216 2217 2218 2219 2220 2221 2222^ 2223 2224 2225 2226 2227 2228 2229 2230 2231 2232 2233 2234 2235
0
75 84 70 53 66 30 74 72 64 88 83 76 86 78 74 30 37 30 75 37 31 74 30
39 37 36 79 39 37 40 73 34
39 75 36
Individual Body Weights (grams)
Week Number: 123
78 99 81 101
95 96
66 96 87
63 100
82
72 96 103
45 91 - 85
59 97 100
55 70 81
66 82 72
68 78 79
76 86 86
73 95 86
80 92 106
58 65 75
48 55 66
36 73 82
49 70 84
32 54 69
97 90 82
36 51 63
27 52 69
94 98 108
31 66 81
43 62 75
44 55 67
43 48 67
93 92 93
42 61 76
44 67 75
46 63 73
91 73 77
49 89 90
46 70 89
81 77 83
43 -
CMA 001913
4
81 68 73 70 108 94 110 84 68 82
79 92 105 77 181 105 88 67 75 70 81 107 72 78 73 75 86 85 78 83 135 86 93 76 -p
9*tdt*Uual B I O T E S T lab&iai&uei, j*tc.
79 CQKFIB^TIAI/
i' Subject to Protective Cr^r m
Boss v. Conoco, Ire.. No- 99-4837
TABLE HI continued
^dlciai fillet C^rt
A; `Calcasieu Parish, Louisiana TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
TE-III Male Hamsters
Animal Number
2236 2237 2238 2239 2240 2241 2242 2243 2244 2245 2246 2247 2248 2249 2250 2251 2252 2253 2254 2255 2256 2257te 2258 2259 2260 2261 2262 2263 2264 2265 2266 2267 2268 2269 2270
0
50 40 37 36 36 34 35 31 34 43 35 43 67 68 66 78 79 62 73 36 74 37 78 85 65 71 77 74 67 73 84 74 79 66
72
Individual Body Wei ghts (grams)
Week Number: 1 2 3'
43 65 80
43 58 73
41 59 69 52 77 88
52 71 81
46 62 71
45 60 73
37 59 71 53 68 77
49 70 83
51 78 88
48 59 69 74 98 101
79 88 79 90 88 100
91 89 93
93 100 105
85 93 98
91 95 98 52 79 84
96 105 103
44 73 72
90 103 107
97 112 112
79 90 85 64 67 76 72 93 94
57 88 86
66 92 93
79 100 101
88 101
92
80 82 85
92 92 83
83 85 77
85 83 82
'4
84 81 78 96 85 81 84 ' 85 87 92 92 78 101 84 84 81 112 104 98 69 94 81 97 100 68 78 82 80 85 101 78 96 83 87 75
001914
9*tddhial B I O - T E S T Jahvtafouei, 9*c. TABLE III continued
80
C01IPIDZNTIAL
Subject to Protective! Crier in Boss v. Conoco, Inc., Bo. 90 -4B-3
14th Judicial District Court jCaloasieu Parish* Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
TE-III Male Hamsters
Animal Number
2271 2272 2273 2274 2275 2276 2277 2278
2279 2280 2281 2282 2283 2284 2285 2286 2287 2288 ` 2289 2290 2291-wi 2292 2293 2294 2295 2296 2297 2298 2299 2300 Mean
0
81 65 36 70 63 67 73 74 85 77 57 58 72
39 75 70 35 71 62 70 70 73 69 79 36 86 37 36 73 66 60
Individual Body Weights (grams)
Week Number: 123
92 96 98
83 86 87
34 60 67
87 98 98
41 91 93
83 105
83
87 109 111
92 89 102
85 97 86
82 98 88
94 105
94
77 87 84
56 72 72
43 64 80
85 104 104
72 88 93
51 56 64
73 97 76
79 85 89
87 68 106
90 86 / 9 5
109 85 92 71 69 80
101 101 111
50 56 65
103 103 105
37 61 71
31 60 76
77 102 110
75 65 88
66 83 86
4
92 94 68 98 94 89 115 88 106 93 97 100 80 92 98 89
-
82 84 108 96 82 81 100 76 108 72 73 97 75 87
CMA 001915
JIttdudttial B I O - T E S T labyiai&tiei, 9*tc.
COHE-ISSllTI AI* 81
Subject to Protective Orfsr in
Boss v. Conoco,
No. 30-4837
~~Uth Judicial District Cou-t
TABLE III continued ... Calo&sieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chi oride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
TE-III F emale Hamsters
Animal Number
2301 2302 2303 2304 2305 2306 2307 2308
2309 2310 2311 2312 2313 2314 2315 2316 2317 2318 2319 2320 2321 232fc 2323 2324 2325 2326 2327 2328 2329 2330 2331 2332 2333 2334 2335
0
33 72 73 67 70 83 63 77 86 73 69 73 72 80 78 74 73 64 81 72 77 76 73 66 81 81 73 79 67 69 60 68 71 66 66
Individual Body Weights (grams)
Week Number: 123
43 -
-
61 57 79
100 81 93 79 75 95
71 82 111
110 110 126
77 98 109
69 97 88
79 96 106
73 99 no
66 88 99
69 90 103 59 85 96
98 118 125
83 94 101
62 75 82
68 82 84
66 81 89
69 96 99
74 83 91
84 104 113
79 103 121
73 99 117
70 87 98
96 102 111
97 119 126
88 102 111
98 114 123
90 106 117
92 100 111
78 95 107
82 92 105
75 97 108
70 91 89
68 90 78
'4
-
89 100
92
123 136 116
99 100 122
91 97 93 118 107 80 81 84 91 94 106 104 no 96 102 98 102 104 105 97 94 90 111 76 75
CMA 001916
DnduiUial B I O - T E S T 2aio\at&Ue&, 9c.
CONFIDENTIAL 82
Subject to Protective Order in Ross v. Conoco, Inc., No. 90-4837
TABLE III continued
14th Judicial District Court Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
TE-III F emale Hamsters
Animal Number
2336 2337 2338 2339 2340 2341 2342 2343 2344 2345 2346 2347 2348
2349 2350 2351 2352 2353 2354 ` 2355 2356 235^ 2358 2359 2360 2361 2362 2363 2364 2365 2366 2367 2368 2369 2370
0
75
69 75 70 75 68 73 77 72 78 55 70 54
72 71 66 63 84 73 33 36 78 76 80
69 65 77 85 77 64 75 67 50 41 44
Individual Body Weights (grams)
Week Number: 12
79 98 113
76 96 107
75 94 98
68 96 104
72 103 112
82 89 99
71 103 113
66 94 106
83 103
98
59 94 89 54 75 74
73 95 99
39 -
-
58 75 81
71 82 89
50 69 75
65 76 88
79 101 107
91 95 98
38 -
-
54 67 70
63 76 77
83 85 96
89 103 112
74 93 104
54 73 93
70 80 96
77 90 108
66 100
99
60 86 74
58 90 90
66 77 91
48 56 64
73 66 77
72 88 93
4
113 118
109 111 127
94 117
129 102
94 67 100 -
73 . 76
59 75 99 98
-
68 67 94
109 101
90 90 99 102 68 91 90 58 69 73
001917
Jl*ududhial B I O - T E S T J.aJositit&uei., 9*tc,
CONFIDENTIAL 83
subject "to Pxmoj*_o^iL*, :
TAR Lr ttt
Ross v. Conc-n t
Sr ln
V4+h
o. 90-4837
> a pi* Judicial District Court
TABLE HI continued... Calcasieu Parish,. Louisian*
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
TE-III Female Hamsters
Animal Number
2371 2372 2373 2374 2375 2376 2377 2378 2379 2380 2381 2382 2383 2384 2385 2386 2387 2388 2389 - 2390 2391
2394^ 2393 2394 2395 2396 2397 2398 2399 2400 Mean
0
78 75 58 37 73 62 38 38 67 70 69 74 63 77 72 71 55 88 68 86
91 65 76 64 88 81 83 72 73 75
69
Individual Body Weights
(grams) Week Number: 1 2 3'
79 102 105 76 90 99 77 89 100 35 62 76
55 78 91 58 82 96 33 63 69 38 64 81 68 73 83 101 95 76 65 79 93 87 85 84 66 80 91 83 93 103 64 90 92 61 88 93 60 78 88 75 97 95 62 86 101 79 105 114 70 91 95 54 68 71 73 87 85 54 76 77 68 73 79 66 68 84 75 85 95 61 67 71 64 78 94 63 54 70 70 87 95
4
100 94 97 81 93 90 66 77 81 77 56
79 96
99 . 94
94 85 83 75 100 52 54 88 81 80 86 87 66 94 70 92
001918 a1-
jwLutual B I O - T E S T Ja&ona&yueA, TABLE III continued
COKFIESN-i Subject to Protect!
1
Boss v. Conoco, Inc- JV. 14th Judicial list :ict Court
^.v Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
TE-IV F emale Rats
Animal Number
2501 2502 2503 2504 2505 2506 2507 2508
2509 2510 2511 2512 2513 2514 2515 2516 2517 2518 2519 - 2520 2521
2524, 2523 2524 2525 2526 2527 2528 2529 2530 2531 2532 2533 2534 2535
0
198 182 170 180 169 176 187 198 183 182 204 197 177 168 171
191 173 192 190 192 165 192 166 175
159 179 189 186 175 175 183 182
169 182
163
Individual Body Weights (grams)
Week Number: 123
223 211 190 213 198 210 217 225 214 214 230 227 207 197 200 220 208 222 211 170 194 228 206 208
199 209 219 217 205 207 214 216 197 213 182
238 226 216 227 217 230 202 242
209 234 246 251 227 215 214 241 210 236 224 205 175 250 223 232 223 211 221 201 208 207 234 233 216 217 196
256 241 227 235 232
239 220 271 235 241 259 252 239 224 225 258 225 252 243 231 194 , 260 232 243 237 231 247 239 237 229 251 252 228 235 210
`4
278 261 245 244 251 248 242
' 299 263 250 278
259 254 235 232 276 237 268 263 256 207 270 246 252 256 248 267 252 256 248 279 268 244 262 224
CMA 001919
Dududiiial B I O * T E S T JialtOAoltyuei, 9*t.
85
.cohfidsittial
Subject to Protective Order in Ross_v. _Conoco, Inc, , i;0. so-4837
TABLE III continued 14th Judicial District Court
Calcasieu Parish, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
TE-IV Female Rats
Animal Number
2536 2537 2538 2539 2540 2541 2542 2543 2544 2545 2546 2547 2548 2549 2550 2551 2552 2553 - 2554 2555
255&* 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 2569 2570
0
188 171 167 171 199 167 194 184 196 179 195 179 167 190 172 174 183 176 219 168 179 182 182 168 189 189 175 177 182 182 188 173 185 191 170
Individual Body Weights (grams)
Week Number: 1 2 3'
4
213 229 243 258
195 217 228 236
194 216 226 240
208 220 229 240
229 252 260 267
182 205 212 219
210 226 240 260
211 221 239 263
216 238 251 282
208 228 250 269
225 241 255 263
208 215 227 240
182 195 210 224
217 240 252 266
201 216 232 253
189 203 211 215 212 228 233 241
226 236 243 257
241 263 271 280
192 221 230 239
212 214 222 230
214 221 228 238
215 242 257 269
183 217 223 225
217 244 265 272
228 230 235 245
204 216 229 241
207 228 240 253
212 227 235 248
2 i 1 225 233 243
213 241 256 275
202 228 240 258
217 235 240 266
221
233
244.
255
182 195 217 228
CMA 001920
SttdudbuaL BIO-TEST ^a&>fc2tosuedt sue*
r.otiTlBi-^jAzL86
Subject to
Boss v. Conoco,
TABLE III continued
^Ctahlcasieu
M0
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Individual Body Weight Data
Group Sex and Species
TE-IV Female Rats
Animal Number
2571 2572 2573 2574 2575 2576 2577 2578 2579 2580 2581 2582 2583 2584 2585 2586 2587 2588 2589 2590 2591 259* 2593 2594 2595 2596 2597 2598 2599 2600 Mean
0
174 160 176 162 188 179 181 188 158 193 162 169 177 193 186 174 176 204 189 196 181 192 192 179 205 168 194 188 182 191 181
Individual Body Weights (grams)
Week Number: 1 2 3'
"4
203 218 256 271
195 225 232 237
206 219 237 251
191 216 224 237
217 223 234 241
209 230 243 260
204 213 229 242
215 232 244 267
187 198 210 223
221 230 143 266
192 204 217 229
198 218 231 252
208 219 233 256
226 250 258 261
215 229 237 268
205 204 224 237
206 205 218 228
223 238 248 256
218 237 248 261
228 245 259 274
210 225 237 269
218
225
i 244
261
222 236 249 263
207 219 231 240
218 234 247 261
181 196 216 230
216 239 253 263 217 229 242 251
205 209 222 237
200 212 236 248
209 223 236 251
CMA 001921
Undtuttetd B I O - T E 5 T 2aLo*aiMie&, 9*c. TABLE IV
C0IT?I3?^I *7,
87
Su^j ect~to~P^t^n--
50^7. Cono-o
Ve Crd9r ln
14th
90 4837
Calcasieu Parish]" LouVia^
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and Species
Cage Number
Animals per Cage
Monthly Body Weight
(grams)
Month
Animals
2 per Cage-
Control Male Rats
-
1 2 3 4 5 6 7 8
9 10 11 12 13 14 15 16 17 18
19 20
a.* 21 22 23 24 25 26 27 Total Mean
3 3 4 4 3 3 3 3 4 4 3 3 3 3 4 4 3 3 4 5 4 4 5 4 4 5 5 100
1,401 1, 286 1, 848 1, 867 1,419 1,280 1, 250 1, 362 1, 768 1, 787 1, 314 1, 320 1,219 1,361 1, 727 1, 808 1, 310 1, 500 1, 888 2,427 1, 835 2, 062 2,216 1,998 1,921 2, 174 2.219 45,567
456
3 3 4 4 3 3 3 3 4 4 3 3 3 3 4 4 3 3 4 5
4; 4 5 4 4 5 5 100
.Month 3
1, 578 1,441 2, 107 2, 159 1,479 1,432 1,400 1, 548 1, 972 2, 026 1,473 1, 514 1,489 1, 311 1,947
2,029 1,457 1, 686 2, 210 2,259 2, 032 2, 170 2,250 2, 165 2, 159 2,245 2.216 49,754
498
CMA 001922
9+tdudliial B I O * T E S T XakvuitcvU&i, Una,
,, ,,T _
.,
TABLE IVcontinued
CONFIDE?!? IAI, 88
Subject to Protective Order in
.ffOBg v. Conoco, Inc., ?;a, 90--'337
14tl1 Judicial District Court Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and Species
Cage Number
Animals per Cage
Monthly Body Weight
(grams)
Month
Animals
2 per Cage-
. Month 3
Control F emale Rats
-
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
19 20 21 22 23 24 25 26 27 Total Mean
3 3 4 4 3 3 3 3 4 4 3 3 3 3 4 4 3 3 4 5 4 4 5 4 4 5 5 100
855 811 1,080
1, 089 857 787 822 860
1, 067 1, 045
820 793 816 742 1, 131 1, 108 858 865 1, 125 1,420 1, 084 1, 198 1, 324 1, 173 1, 115 1,267 1. 367 27,479 275
3 906 3 903 4 1,215 4 1,209 . 3 924 3 863 3 876 3 932 4 1, 134 4 1, 142 3 921 3 874 3 824 3 917 4 1,209 3 928 3 899 3 935 4 1, 242 5 1, 563 4 ; 1, 158 4 1,298 5 1, 432 4 1, 256 4 1, 194 5 1, 319 5 1.489 99 29,562
299
CMA 001923
UIU - 1 3 I J.aua-'uUaue^, 'J*c.
CONFIDENTIAL Subject to Protective Crder in goss 7. Conoco, Ino., Iio. SO-4837 TAB JLE IV continued 14th Judicial District Court u-.:. Calcasieu Parish,, Louisiana TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and Species
Cage Number
Animals per Cage
Monthly Body Weight
(grams)
Month
Animals
2 pe r Cage
Month 3
Control Male Mice
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
19 20 21 22 23 24 25 26 27 28
29 30 31 32 33 34 Total Mean
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 1 100
120
,129 127 130 127 122 121 118 124 107 125 118 130 130 125 121 117 134 128 122 117 120 133 125 124 115
129 129 127 125
119 120 116
37
4, 111 41
3 117
3 146
3 143
3 143
3 110
3 130
3 136
2 68
3 118
3 119
2 109
3 79
3 144
3 133
3 121
3 132
3 121
3 135
3 133
3 123
3 122
3 130
3 142
3 132
3 123
3 123
3 136
3 CN
3 3 oo 3
144 134 137 128
3 127
3 124
1 38
98 4, 200
43
9*tdmi%iaL B I O - T E 5 T la&wialtvU&i, 9tax
COffFISZITTIAI 90
Subject to Protec li'vo Order in 5os3_v. Conoco, Ire,, No. 00-4837
TABLE IVcontinued ^4th Judicial District Court - Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and Species
Control F emale Mice
Cage Number
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 Total Mean
Animals per Cage
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
1
100
Monthly Body Weight
(grams)
Month
Animals
2 per Cage
92 96 88 97 94 97
91 94 94 113 101 104 106 100 102 84 94 112. 94 108 107 104 93 98 102 92 101 100
no
108 105 104 112
31 3, 328
33
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
1
100
Mon _3
108 106
99 102 104 109 .99 107 105 107 106 111 114 115 111
89 106 120 105 109 111 108 102 101 110 96
95 93
104
104 105 113 106
30 3, 510
35
CMA 001925
!)itdu&&ual B I O - T E S T laJwaioAieS, One. TABLE IVcontinued
91 CONFIDENTIAL
Subject to Protective Ori^r >n Boss v. Conoco, Ir.o.. Do. 93 - vqj
J-4th Judicial District Court ViL.-Caloasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethytene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and Species
Control Male Hamsters
Cage Number
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 Total Mean
Animals per Cage
4 4 4 4 2 4 4 4 2 4 4 4 3 3 2 2 3 2 2 3 3 3 3 3 3 3 3 3 3 1 92
Monthly Body Weight
( grams)
Month
Animals
2 per Cage
Month 3
452 .441 407 439
191 430 455 396 198 416 421 441 303 331 278 223 372 220 237 297 276 245 353 372 351 256 328 368 341 129 10, 084 110
4 500 4 511 4 458 4 472 2 202 4 481 4 489 4 418 2 249 4 390 4 408 4 501 3 356 3 402 2 315 2 235 3 430 2 249 2 271 3 359 3 313 3 281 3 413 3 422 3 341 3 300 3 403 3 470 3 320 1 104 92 11,063
120
CMA 001926
!)ncLuit%iai B I O - T E S T ^a&oncdtvu&i, 9*tc,
TABLE IVcontinued
92 CONFIDENTIAL Subject to Protective Order in Boss v. _Cor.o:;o. Inc., bo, 90-i33
14th Judicial District Court v.Calcasieu Parish* Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
G r oup, Sex, and Species
Cage Number
Animals per Cage
Monthly Body Weight
(grams)
Month
Animals
2 per Cage
Month 3
Control Female Hamsters
1 2 3 4 5 6 7 8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
29 30 Total Mean
3 4 3 4 4 4 4 4 4 4 4 2 3 1 3 3 3 2 2 3 3 3 3 2 3 2 2 3 3 1 89
249 466 213 442 560 428 402 456 316 425 282 227 294 158 373 312 379 209 224 370 351 341 315 266 364 198 230 308 326 110 9, 594 108
3 304 4 479 3 294 4 497 4 588 4 456
4 425 4 483 3 263 4 470 3 271 2 252 3 303 1 144 3 385 3 346 3 409 2 222 2 216 3 382 3 398 3 369 3 307 2 239 3 388 2 221 2 254 3 342 3 398 1 126 87 10,231
118
CMA 001927
UncLuhial B I O - T E S T 2ahviato'tie&, Hue.
93
CONFIDENTIAL
Subject to Protective Order Boss v. Conoco, Inc,, Do. SC - !-3o
TABLE IVcontinued 14th Judicial District Court
' v'.. Calcasieu Parish, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and Species
Cage Number
Animals per Cage
Monthly Body Weight
(grams)
Month
Animals
2 per Cage'
Month 3
TE-I Male Rats
1 2 3 4 5 6 7 8
9 10 11 12 13 14 15 16 17 18
19 20 21 22 23 24 25 26 27 Total Mean
3 3 4 4 3 3 3 3 4 4 3 3 3 3 4 4 3 3 4 5 4 4 5 4 3 4 5 98
1,363 3 1, 501 1, 314 3 1,413 1,713 4 1, 873 1, 806 4 2, 009 1,432 3 1, 560 1, 318 3 1,418 1,269 3 1,471 1, 348 3 1, 556 1, 773 4 2, 025 1, 654 4 1, 803 1, 391 3 1, 551 1,476 3 1, 633 1, 346 3 1, 519 1,459 3 1, 627 1,796 4 1,984 1, 832 4 2, 015 1, 305 3 1,464 1, 383 3 1, 527 1,906 4 2, 149 2, 198 5 2,217 1, 835 4 2, 021 1,870 4 2, 120 2, 170 5 2, 195 1, 779 4 2, 020 1, 305 3 1, 374 1, 704 4 1,893 2, 157 5 2,210 43,902 98 48, 148
448 491
CMA 001928
DtuLtAbuol B I O - T E S T lahyiahyueA, Sue.
TABLE IVcontinued
CONFIDENTIAL 94
Subject to Protective Order in Ross v. Conoco, Inc., No . 90 -133
14th Judicial District Court ... Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and Species
Cage Number
Animals per Cage
Monthly Body Weight
(grams)
Month
Animals
2 per Cage
Month 3
TE-I Female Rats
1 2 3 4 5 6 7 8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 Total Mean
3 3 4 4 3 3 3 3 4 4 3 3 3 3 4 4 3 3 4 5 4 4 5 4 4 5 5 100
793 853 1, 112 1, 108 825 823 871 835 967 1,097 765 843 833 862 1, 142 1, 167 807 866 1, 133 1, 354 1, 126 1, 121 1, 364 988 1, 092 1,338 1, 342 27,427 274
3 3 4 4 3 3 3 3 4 4 3 3 3 3 4 4 3 3 4 5 4 4/ 5 4 4 5 5 100
834 889 1,218 1, 164 907 880 906 894 1, 145 1, 167 804 911 869 898 1, 284 1, 233 854
891 1,239 1,499 1,203
1,219 1, 536 1, 104 1, 212 1,485 1.497 29,742
297
CMA 001929
3Htli*ibual BIO-TEST <dianol3'UeA, 3*te. TABLE IV continued
95 .COffFIDgffTIAL
Subject to Protective Order in Boss v. Conoco, Inc.. Lro. 90-4837
14th Judicial District Court Calcasieu Parish,, Louis Una
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and Species
Cage Number
Animals per Cage
Monthly Body Weight
(grams)
Month
Animals
2 per Cage
Mon 3
TE-I Male Mice
1 2 3 4 5 6 7 .8 9 10 11 12 13 14 15 16 17 18
19 20 21 22 23 24 25 26 27 28
29 30 31 32 33 34 Total Mean
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 1 100
126 124 119 107
119 93 94 98
111 116 131 126 117 115 115 115 117 131 115 116 123 115 113 103 117 116 116 123 113 114 122 113 116 42 3, 851 39
3 135 3 141 3 131 2 69
--
3 106 2 67 3 111 3 126 3 132 3 149 3 150 3 141 3 139 3 140 3 136 3 133 3 135 3 125 2 88 3 140 3 131 3 131 3 117 3 143 3 133 3 128 3 128 3 133 3 128 3 125 3 112 3 134 1 45 94 4, 082
43
CMA 001930
JIndudlual B I O * T E 5 T Xah&ialyued., !)*
CONFIDENTIAL
Subject to Protective Order ii Boss v. Conoco, Inc., !<o . `30 - -ISC
14th Judicial District Court
TABLE IVcontinued ^Caloasleu Parish* Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Monthly Body Weight
Group,
(grams)
Sex, and
Cage
Animals
Month
Animals
Month
SpeciesNumberper Cage2per Cage_________________________ 3
TE-I F emale Mice
1 2 3 4 5 6 7 8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34
Total Mean
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 1 3 3 3 3 3 3 3 3 3 1
97
91 94 101 90 94 102 98 94 94 95 112 100 119 104 104 105
99 74 102 101 98 95 96 34 127 106 98 107 101 88 95 96 105 40
3,259. 34
3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 2 3 3 3 3 3 1 3 3 3 3 3 3 3 3 3 1
96
99 104 112
99 105 114 110 101 106 111 108 76 113 112 115
119 116
74 114 109 114 107 110
36 125 121 112 126 119 104 106 104 111 40
3, 562 37
CMA 0 0 1 9 3 1
Htulit&bUal B I O - T E S T lalwalvUeS, 9*tc.
97
CONFIDENTIAL
Subject to Protective Or^r 'i Ross v. Conoco, Inc., "c. 00 - ' it
TABLE IVcontinued 14th Judicial District "out*? frii .Calcasieu Parish,. Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and Species
TE-I Male Hamsters
Cage Number
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 Total Mean
Animals per Cage
'3 3 4 4 4 4 3 4 4 3 3 4 2 3 3 3 3 3 3 3 2 2 3 3 3 3 1 3 3 1
90
Monthly Body Weight
(grams)
Month
Animals
2 per Cage
Month 3
327 273 373 406 467 485 252 334 404 205 332 403 202 340 296 317 322 302 264 204
191 219 339 340 316 276
89 330 316
96 9, 080
101
3 2 4 4 4 4 3 4 4 3 3 4 2 3 2 3 3 3 3 3
2 2' 3 3 3 3 1 3 3 1 88
385 228 397 455 535 515
239 388 458 283 318 501 264 402 211 287 347 367 324 240 223 264 395
391 364 312
94 345 351 114 9,997 114
CMA 001932
9*tdudt>Ual B I O * T E S T
9*tc. TABLE JVcontinued
CONFIDE!? TIAI98 Subject to Protective GiNer in Ross y. Conoco. Ir.o., Ho. 00-403
14th Judicial District Court Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and Species
Cage Number
Animals per Cage
Monthly Body Weight
(grams)
Month
Animals
2 per Cage
Month 3
TE-I F emale Hamsters
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
19 20 21 22 23 24 25 26 27 28
29 30 Total Mean
4 4 4 4 4 4 4 4 4 4 3 4 1 3 1 3 2 2 2 3 2 2 3 3 3 3 2 2. 3 1 88
463 368 410
389 436
429 407 337 427 408
239 398
94
359 63
315 196 174 187 306 202 226 295 313 309 346 212 227 315 100 8, 950 102
4 514 4 403 4 462 4 427 4 484 4 523 4 446 4 401 4 46 5 4 492 3 241 4 402 1 97 3 357 1 77 3 341 2 179 1 102 2 229 3 314 2 221 2 230 3 343 3 325 3 348 3 377 2 254 2 243 3 344
--
86 9, 640 112
CMA 001933
!)ncL4it'uai B I O - T E S T
TAB LE IV continued
99 CONFIDENTIAL
Subject to Protective 3V-Boss v. Conoco, Inc. , Co. 00 - t j j'/
T4th Judicial District Court Cvvi,-Calcasieu Parish,. Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and Species
Cage Number
Animals per Cage
Monthly Body Weight
(grams)
Month
Animals
2 per Cage
Month 3
TE-II Male Rats
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 Total Mean
3 3 4 4 2 3 3 3 4 4 3 3 3 3 4 4 3 3 4 5 4 4 5 4 4 5 5
99
1,298 1,346 1, 816 1, 895
929 1,317 1, 305 1,397
1,769 2, 047 1,494 1,404 1,284 1, 353 1,818 1,795 1, 370 1,446 2, 004 2, 189 1, 858 1, 884 2, 184 1, 881 1, 810 2, 210 2, 164 45,267
457
3 3 4 4 2 3 3 3 4 4 3 3 3 3 4 4 3 3 4 5 4 4` 5 4 4 5 5
99
1, 353 1, 518 1,928 2,093 1,011 1,531 1, 372 1, 523 1,962 2, 177 1,642 1, 560 1, 558 1, 307 1,945 1,943
1,499 1, 571 2, 180 2, 210 2, 061 2, 032 2, 148 2, 067 1,951 2, 202 2,201 48, 545
490
CMA 001934
Undudi'ual tt I O * I t i I JLait&iai&u&i; J*uz.
TABLE iV continued
uoject to Protective Crd=r In v- ^onoco,_lnc^ No. s3-4837
I4th Judicial District Court
Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and Species
Cage Number
Animals per Cage
Monthly Body Weight
(grams)
Month
Animals
2 per Cage
Month 3
TE-II F emale Rats
1 2 3 4 5 6 7 8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 Total Mean
3 3 4 4 3 3 3 3 4 4 3 3 3 3 4 4 3 3 4 5 4 4 5 4 4 5 5 100.
823 870 1, 172 1,098 847 896 882 872 1, 113 1,093 905 873 920
909 1, 136 1,224
895 866 1, 127 1,417 1, 210 1,098 1,462 1,202 1, 104 1,416 1,460 28, 890 289
3 3 4 4 3 3 3 3 4 4 3 3 3 3 4 4 3 3 4 5 4 4/ 5 4 4 5 5 100
876 885 1, 225 1, 157 886 960 848 890 1,206 1, 110 931 920 940 935 1,205 1, 258 925 887
1, 189 1,487 1,277 1, 157 1, 535 1,264 1, 166 1,497 1. 550 30, 166
302
CMA 001935
^ndaditial B I O - T E S T 2aluvtat&tiei, 9nc. TABLE XVcontinued
101
COHFIDEffTIAL
Subject to Protective Order in Ross v. Conoco, Inc.. Do. SO-4337
14th Judicial District Court u._ Calcasieu Parish,, Louisian*
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and
Species
Cage Number
Animals per Cage
Monthly Body Weight
(grams)
Month
Animals
2 per Cage
Month 3
TE-II Male Mice
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
29 30 31 32 33 34
Total Mean
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 1
100
121 123 130 123 115 117 110 114 117 122 103 116 112 123 122 129 118 114 108 108 112 110 103 97 113 119 111 118 121 119 121 117 112
29 3,847
38
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 1 1 3 1
96
130 131 140 129 129 119 129 120 130 134 114 129 138 132 128 141 114 123 117 116 129 117 112 113 127 133
119 131 133 135 42 42 123 47
4, 046 42
001936
OndtUlual B I O - T E S T jta^onaiyuei., Onc.
TABLE IVcontinued
C0N7IPE1TTIAL102
Subject to Protective Crdcr in Boss v. Conoco, Inc., Mo. 90-433?
14th Judicial District Court
Calcasieu Parishv
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and Species
Cage Number
Animals per Cage
Monthly Body Weight
(grams)
Month
Animals
2 per Cage
Month 3
TE-II Female
Mice
1 2 3 4 5 6 7 8
9 10 11 12 13 14 15 16 17 18
19 20 21 22 23 24 25 26 27 28
29 30 31 32 33 34 Total Mean
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 1 100
102 104 112 100 101 103
93 102
97 104 106
98 107 103 113 106 101 102 102 102 107 116 110 100 106
94 103 109 no 101
85 118
95 31 3,443 34
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 1 100
93 98 109 95 101
99 93 97 91 104 103 101 no 97 107 106 100 106 100 105 107 115 ' 104 114
109 103 104 115 113 108 109 121 128 43 3, 508 35
CMA 0 0 1 9 3 7
Otidndtrual BIO-TEST Aaltonaioniei; 9*ic.
TABLE IVcontinued
COffPIDPZTTIAL 103 Subject to Protective Order in Boss v, Conoco. Inc., Do. 90--1337
14th Judicial District Court Calcasieu Parish, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and Species
Cage Number
Animals per Cage
Monthly Body Weight
(grams)
Month
Animals
2 per Cage
Month 3
TE-II Male Hamsters
_
1 2 3 4 5 6 7 8
9 10 11 12 13 14 15 16 17 18
19 20 21 22 23 24 25 26 27 28
29 30 Total Mean
4 4 4 4 4 4 4 4 4 4 4 4 2 3 3 2 2 2 2 3 2 2 3 3 3 3 3 1 3 1
91
365 375 360 350 311 416 375
349 301 323 297 348 186 250 256 211 214 190 177 315 225 207 324 225
289 289 334 103 349 101 8, 531
94
4 4 4 4 4 4 4 4 4 3 4 3 2 3 3 2 2 2 2 3 2 2' 3 2 3 3 3 1 3 1 88
372 419 385 386 346 441 406 346 305 256 333 276 176 250 258 211 232 214 186
349 250 265 332 161 310 336 363 115 350 100 8, 729
99
CMa 1938
9nd*4di/ual B I O * T E S T Jahnafoued., Due.
104
COHFID^TTIAL
Subject to Protective C.inr in
_ Ross v. Conoco, Inc,, 'o. 50 - id TABLE IVcontinued---- ~th Juilclal ^strict Court
Calcasieu Parish,, Louisiana TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study- Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and Species
Cage Number
Animals per Cage
Monthly Body Weight
(grams)
Month
Animals
2 per Cage
Month '3
TE-II F emale Hamsters
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
29 30 Total Mean
3 4 4 3 2 2 4 4 4 1 2 3 2 3 3 3 3 3 3 3 3 3 2 2 3 3 2 3 3 1 84
328 463 335 248 206 158 415 411 364
85 183 230 192 306 336 347 32 6 235 270 332
359 290 237 198 350 302 155 256 315
58 8,299
99
3 4 4 3 1 2 4 4 4 1 1 3 2 3 3 3 3 3 3 3 3 3 2 2 3 3 2 3 3 1 82
278 462 380 272 123 183 . 472 454 366 101 104 247
219 320 376 430 349 287 288 337 375 303
279 233 381 304 191 282 355
67 8, 818
108
CMA 001939
!)rtdiut'Ual B I O * T E S T
9*tc. CONFIDSrfTiAL 105
Subject to Protective Orde- in
v- Conoco, Inc, .
v) - l<33
TABLE jVcontinued
14tb Judicial District Court
Av. Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study. - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and Species
Cage Number
Animals per Cage
Monthly Body Weight
(grams)
Month
Animals
2 per Cage
Month 3
TE-III Male Rats
1 2 3 4 5 6 7 8
9 10 11 12 13 14 15 16 17 18
19 20 21 22 23 24 25 26 27 Total Mean
3 3 4 4 3 3 3 3 4 4 3 3 3 3 4 4 3 3 4 5 4 4 5 4 4 5 5 ioa
1,448 1,300 1,777 1, 877 1, 345 1,466 1,343 1,420 1,995
1,779 1, 356 1,401 1, 336 1,494 1, 815
1,879 1, 380 1,149. 1,807 2, 317 1, 820 1, 854 2, 161 1,696
1,769 2,199 2, 125 45,308
453
3 3 4 4 3 3 3 3 4 4 3 3 3 3 4 4 3 2 4 5 4 4 5 4 4 5 5
99
1, 543 1, 530 1,997 2, 063 1,462 1, 708 1, 531
1,539 2, 142 1,905 1,405 1, 513 1,449 1, 685 2,057 1,948 1, 504
981 2, 032 2,413 2,007 2, 021 2, 396 1,927 1, 909 2,417 2. 326 49,410
499
CMA 001940
Dudustfual B I O - T E S T Jtah&u2i&,ue&,
, gl
CONFIDENTIAL
Subject to Protective Ortfer in Boss v. Conoco, Inc.. Ko. 90-4357
TABLE IVcontinued 14th Judi2ial District Court , Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and Species
Cage Number
Animals per Cage
Monthly Body Weight
(grams)
Month
Animals
2 per Cage
Month 3
TE-III F emale Rats
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 Total Mean
3 3 4 4 3 3 3 3 4 4 3 3
3. 3 4 4 3 3 4 5 4 4 5 4 4 5 5 10Q
911 881 1, 140 1, 111 854 1, 182 814 854
1, 139 1, 127
835
929 830 854 1, 205
1, 119 796 833
1, 136 1,409 1, 176 1, 172 1, 386 1, 108
1, 139 1,391 1,347 28,678
287
3 3 4 4 3 3 3 3 4 4 3 3 3 3 4 4 3 3 4 5 4 4 5 4 4 5 1 96
961 882 1, 143 1, 124 929 1,235 842 901 1, 185 1, 211 877 973 868 872 1, 302 1, 187 857 923 1, 197 1, 501 1,276 1,252 1,478 1, 131 1,205 1,478 262 29,052 303
CMA 001941
^tuluiUxial BIO-TEST jtaJuytativUei, 9nc.
coi??ids;ttial 107
Subject to Protective Or^er in Ross v. Conoco, Irc., I'c. 30-4337
TABLE IVcontinued
Judicial District Court
s-. Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and Species
Cage Number
Animals per Cage
Monthly Body Weight
(grams)
Month
Animals
2 per Cage
Month 3
TE-III Male Mice
1 2 3 4 5 6 7 8
9 10 11 12 13 14 15 16 17 18
19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 Total
Mean
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 1 100
112 121 118 123 124 118 127 110 118 126 115 118 124 128 126 127 12 4 114 145 120 120 130 110 124 126 105 120 121 117 119 121 135 123 34 4, 043 40
3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 1
99
127 87
126 132 128 127 135 116 127 135 125 125 126 128 128 136 125 123 154 125 127 133 115 129 127 130 126 128 122
119 124
139 127
39 4, 220
43
CMA 001942
!)ndetdl%ial B 1 O - T E S T 2a/nviaio4ie&, 9*tc~
108 CONFIDENTIAL
Subject to Protective Order in Boss v. Conoco, Inc., ;:o. 30-4337
TABLE iVcontinued
14th Judicial District Court
V.A- Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study' - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and Species
Cage Number
Animals per Cage
Monthly Body Weight
(grams)
Month
Animals
2 per Cage _
Month 3
T E - III F emale Mice
1 2 3 4 5 6 7 8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
29 30 31 32 33 34 Total Mean
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 1 100
108 105 101. 101 102
99 99 86 106 96 96 97 98
99 110 106 102 100 105 107 111 105 104 106 101 103
96 92 97 106 106 93 95 39 3, 372 34
3 3 3 3 3 3' 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 1 100
109 104
96 96 102 102 108 100 111 101 98 95 97 97 114 103 97 105
109 106 111 111 104 104 104 111
98 95 102 108 117 102 102 46 3, 375
34
CMA 0 0 1 9 4 3
J+uLutiial B I O - T E S T labyiat&Uei, 3etc. TABLE IVcontinued
109 CONFIDENTIAL Subject to Protective Crtor in Ross v. Conoco, Inc..To. vO-433
14th Judicial District Court v.i. Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and Species
Cage Number
Animals per Cage
Monthly Body Weight
(grams)
Month
Animals
2 per Cage ..
Month 3
TE-III Male Hamsters
-
1 2 3 4 5 6 7 8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 Total Mean
3 4 4 4 4 4 4 4 3 4 4 4 2 3 3 3 2 3 2 2 3 3 3 1 2 3 3 3 2 1 90
254 413
319 376 326 345 368 425 292 410 352
389 147 300 264 248 165 273 201 175 245 252 307
83 177 326 261 295 147 121 8, 155
91
3 4 4 4 4 4 4 4 3 4 4 4 2 3 3 3 2 3 2 2
3/ 3
-
-
2 3 3 3 2 1 86
245 437 314 407 351 342 - 327 418 292 433 367 417 157 291 297 249 191 295 181 160 276 273
-
-
183 305 282 305 151
74 8, 020
93
CMA 001944
^ndHdt/uai B I O - T E S T -laitonatosuei., 9*tc. TABLE IVcontinued
.CONFIDSff:
110
Subjec-Pto p^ots-t7
Hoss^v. .Conoco], rV0
JL ~*0 - - \bo 14tb Judicial Dish - u v.0ili. Z .u. Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Group, Sex, and Species
Cage Number
Animals per Cage
Monthly Body Weight
(grams)
Month
Animals
2 per Cage -
Month 3
TE-III F emale Hamsters
`
1 2 3 4 5 6 7 8
9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 Total Mean
3 4 4 4 4 4 4 4 4 4 4 3 2 3 1 3 3 3 3 3 3 2 2 3 3 3 1 2. 2 1
89
327 489 440 425 347 417
359 392 490 480 443 280 137 307
71 266 300 302 239 297 240 197 181 298 312 330
55 185 186
77 8, 869
100
3 4 4 4 4 4 4 4 3 3 4 3 2 3 1 3 3 3 3 3 3 2 2 3 3 3 1 2 2 1 87
362 485 467 441 373
479 382 410 345 386 440 307 157
289 70
271 370 331 245 311
269 230 210 363 317 347
59 180 223
84 9,203
106
CMA OO1945
yrtMtitiial B I O - T E S T J,a&&u2ttvue4., Dnc.
CONFIDENTIAL 111
Subject to Protective Order in Boss v. Conoco, Inc., No. 90-4837
14th Judicial District Court TABLE IVcontinued^ Calcasieu Parish,. Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Monthly Body Weight Data
Monthly Body Weight
Group,
(grams)
Sex, and
Cage
Animals
Month
Animals
SpeciesNumberper Cage2per Cage 3
Month
TE-IV F emale Rats
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
19 20 21 22 23 24 25 26 27 28
29 30 31 32 33 34 Total Mean
3 3 3 3 3 3 3 3 3 .3 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 100
895 842 906 882 797 835 793 864 877 841 897 826 821 821 911 795 564 828 861 836
859 861 910 861 822 842 820 802 846 820 889 864 821 528 28,237 282
3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3
3 3 3 3 3 3 3 3 3 3 3 2
100
'
923 839 904 901 793 855 809 869 873 866 915 831
829 849 934 811 598 845 894 875
899 885 916 875 846 860 849 811 892 850 886 831 872 505 28, 790 288
CMA 0 0 1 9 4 6
9*idn&bual B I O - T E S T laAvutfotieii., 9*c,
CONFIDSIIT
Subject to Protect! Ross v. Conoco, Inc -
14th Judicial District Court Calcasieu Parish* Louis4&8&
Behavioral Reactions: No untoward behavioral reactions have been
observed among any species or test levels which can be attributed
to the test material. Occasional acts of cannibalism have been ob
served, primarily among hamsters and occasionally among mice;
however, this is not a dose related effect and has also been noted among
control animals.
Mortality: Mortality checks have been made twice daily (before and after exposure) on exposure days, and daily on non-exposure days. Deaths have been randomly distributed among both control animals and all test level animals. Cannibalism has been the greatest cause of mortalities, and this has been mostly noted in hamsters (primarily males).
Times of death (study day number) during the first three months of testing are presented in Table V.
CMA OO1947
9*%d**&t>ual B I O * T E 5 T ^aboAata'Ued., 9+tc.
TABLE V
CONFIDENTIAL
Subject to Protective Order in Ross v. Conoco, Inc., >;o. 90-1237
14th Judicial District Court Calcasieu Parish,, Louisia04
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Mortality and Gross Observations
Group, Sex, and Species
Animal Number
Day Number of Death
Gross Observations
Control F emale Rats
154
71 Accidental death
Control Male Mice
823 835
94 Normal postmortem changes 94 Accidental death
Consolidation in lung
Control Male Hamsters
1617
1619 1633 1635 1656 1659 1665 1667
9 Cannibalism 46 Cannibalism 51 Cannibalism 54 Cannibalism
3 Cannibalism 3 Cannibalism 15 Cannibalism 12 Cannibalism
Control F emale Hamsters
TE-I Male Rats
1703 1712 1733 1743 1745 1746 1752 1754 1764 1769 1783 1788 1793
289 291
23 8
70 79 52 54 30 53 53 47 38 43 14
47 47
Cannibalism Cannibalism Cannibalism Cannibalism Cannibalism Cannibalism Cannibalism Cannibalism Cannibalism Cannibalism Cannibalism Cannibalism Cannibalism
Escaped Escaped
CMA 0194q
Unduiisual B l O - T E $ T 2aio^atani$d., 9*tc.
C 0j
' - -- -
Su^^ect~bT^^T:~' ni-
i2ss v. Conoco, AV'.J.
TABLE V continued *^th JudiciaT'7)<C7'"~`
^lcasieu Parish^Court
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
^ ^ssiana
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Mortality and Gross Observations
Group, Sex, and Species
Animal Number
Day Number of Death
Gross Observations
TE-I Male Mice
TE-I F emale Mice
TE-I Male Hamsters
TE-I F emale Hamsters
1011 1013 1014 1015 1019 1058
1134 1152 1170 1171
1804 1805 1806 1827 1840 1844 1851 1855 1874 1876 1891 1892
1944 1949 1950 1955 1957 1962 1964 1966 1967 1974 1976 1991 1994 2000
79 85 85 85 92 85
85 54 55 55
61 59 85 51
5 15 47 72 24 ' 29 45 45
54 47 53 - 47 59 40 86 33 31 15 31 55 24 88
Cannibalism Cannibalism Cannibalism . Cannibalism Cannibalism Cannibalism
Cannibalism Cannibalism Cannibalism Cannibalism
Cannibalism Cannibalism Cannibalism Cannibalism Cannibalism Cannibalism Cannibalism Cannibalism Cannibalism Cannibalism Cannibalism Cannibalism
Cannibalism Cannibalism Cannibalism Cannibalism Cannibalism Escaped Cannibalism Cannibalism Cannibalism Cannibalism Cannibalism Cannibalism Cannibalism Escaped
CMA 0 0194 9
UtidmUial
BIO-TEST
2a&&iato'ue&, 9ttc. TABLE
V continued
115
CONFIDENTIAL
Subject to Protective Crier i Ross v. Conoco, Inc.. !;o. CO - 46
14th J`adicial District Court Calcasieu Parish,, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Mortality and Gross Observations
Group, Sex, and Species
Animal Number
Day Number of Death
Gross Observations
TE-II Male Rats
415
64 Normal postmortem changes
TE-II Male Mice
1291 1292 1294 1296
91 Escaped 91 Escaped 91 Escaped 91 Escaped
TE-II Male Hamsters
-
2038 2046
2049 2058 2062 2066 2067 2075 2077 2083 2094 2096
90 Accidental death 85 Cannibalism 46 Cannibalism 10 Cannibalism 10 Cannibalism
8 Cannibalis m 11 Cannibalism 44 Cannibalism
8 Cannibalism 93 Cannibalism 10 Cannibalism 32 Cannibalism
CMA 001950
3*tdudt%Lal B I O - T E S T XaiototoAiAA, H*tc. TABLE
cc:i7iDi:7TtK^
Subject to PrctscTtv; Or"or ; Ross v. Couo-o, Inc . , I;o . 90 - ;
V continued
14th Judicial District Court Calcasieu Parish, Louisiana
TEST MATERIAL: Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Mortality and Gross Observations
Group,
Sex, and
Animal
Day Number
SpeciesNumberof DeathGross Observations
TE-II F emale Hamsters
TE-HI Male Rats
2102 2113 2117 2119 2120 2121 2124 2137 2138 2140 2141 2143 2144 2145 2149 2179 2182 2193
660
9 Cannibalism 52 Cannibalism 52 Cannibalism 87 Cannibalism 60 Cannibalism 39 Escaped 39 Escaped 29 Cannibalism 47 Cannibalism 29 Cannibalism 39 Cannibalism 68 Cannibalism 36 Cannibalism 36 Cannibalism 46 Cannibalism 53 Cannibalism
9 Cannibalism 29 Cannibalism
92 Normal postmortem changes
TE-IH F emale
Rats
TE-III Male Mice
796 797 799 800
1406
78 78 78 78
93
Escaped Escaped Escaped Escaped
Cannibalism
CMA 001951
9ncLulual B I O - T E S T J.aiowit&ued', 9*tc.
TEST MATERIAL:
Subject to PrcTscc.v- O'-'-? <r Ross V. Conoco, Pr.c^ :;o, s 3
TABLE V continued 14th Judicial Disbriot Court Calcasieu Parish,. Louisian^
Vinyl Chloride (Ethylene Derived)
Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters
Mortality and Gross Observations
Group, Sex, and Species
Animal Number
Day Number of Death
Gross Observations
TE-III Male Hamsters
2202 2235 2251 2262 2268 2272
2279 2280 2281 2282 2283 2284 2287 2298
54 Cannibalism 16 Cannibalism 46 Cannibalism 46 Cannibalism 39 Cannibalism 54 Cannibalism 85 Escaped 85 Escaped 85 Escaped 64 Escaped 85 Escaped 64 Escaped 26 Cannibalism
38 Cannibalism
TE-III F emale Hamsters
2301 2335 2339 2348 2350 2355 2357 2377 2381 2391 2393 2396 2397
9 Cannibalism 89 Cannibalism 87 Cannibalism
8 Cannibalism 54 Cannibalism
8 Cannibalism 48 Cannibalism 53 Cannibalism ' 38 Escaped 38 Cannibalism 29 Cannibalism 29 Cannibalism 41 Cannibalism
CMA 001952