Document 9JYNwjJ9znOk5G0eQ1KNnJkkV

william H. Hunt - Medical Department January 23, 1970 Pydraul AC-A Winter Orada 28 Acuta Toxicity Scraan P.D. Fowlkes W.R. Riohard L.R. stark J.P. Herber J.D. Sullivan q.'At \lx l* The undiluted saaple was elaaaad as praotleally non-toxle whan adalnlstared orally to nixed aax rats. The aeiAe oral LD50 was 10,250 ng/kg. Tina to death was 12 hours to 2 days. Toxlo signs ware reduced appetite and activity, lnereaalng weakness, collapse, and death. During the study it appeared that the saaple was slightly nore toxlo to Pennies than to aales. Macro scopic examination of those that succumbed revealed slight liver discoloration, henorrhaglo lungs, and setose gastrointestinal Inflammation. Macroscopic examination of those that were sacri ficed revealed slight liver discoloration and areas of lung con gestion In those receiving the higher doses, while those receiving the lower doses exhibited a normal viscera. The undiluted saaple was olassed as slightly toxle when applied to and retained for 2* hours on the clipped lntaet skin of mixed sex rabbits. The acuta minimal lethal dose was greater than 2000 but less than 3l6to mg/Vi. Time to death sms A to 6 days. Toxic signs were greatly reduced appetite, lethargy, mild diarrhea. Increasing weakness, collapse, and death. Macroscopic examin ation of those that sueeumbed revealed an enlarged gall bladder, hemorrhaglo lungs 1 alight liver discoloration and acute gastro intestinal Inflammation. Macroscopic examination of those that were sacrificed revealed. In scam cases, areas of lung congestion and a slightly enlarged gall bladder. The undiluted saaple was classed as a mild Irritant whan applied to and retained for 2t hours cm the clipped lntaet skin of mixed sex rabbits. Maximum irritation (2/8) occurred 2A hours after the sample was resMved from the skin. The skin was normal (0/8) 96 hours after removal of the sample. The reaotlom at maximum Irritation was well-defined erythema but no edema. The undiluted saaple was classed as a slight Irritant when In stilled and retained for 2t hours in the eonjuaetival sac of the rabbit eye. Msalmimi Irritation (2/110) occurred at 1 hour of contact and consisted of slight erythema with no edema. The eye was normal at 2A hours of oontaot, at which tins it was Irrigated. When male rats were exposed to the saturated vapors of the sample, tot ambient te^erature for 6 hours no deaths occurred. It was concluded that the vapors of this saaple were practically non-toxic. Haoroscoplo exasdnatlon of the sacrificed animals revealed a normal viscera. MUNS 100045 2 No special handling of thlB product appears necessary. In case of excessive skin contact wash off with aoap and water. In case of accidental eye contact, flush out with water. William H. Hunt, Ph.U. MUNS 100046