Document 9JX9nNjNvXVJy3BkXKQJYjOR3

J-)n A ~O /?* r & PLAINTIFF'S EXHIBIT UC-1006 A23 IS!S UCAR EMULSION SYSTEMS UNION CARBIDE CORPORATION 410 GREGSON DRIVE. CARY. N.C. 27511 (9191 469-6700 MEMORANDUM TO: CC: DATE: SUBJECT: B. F. Cole H. V. Hooper K. G. Morlock H. Ortiz D. H. Reed G. W. Sanders - Somerset - Garland - Alsip - Bayamon - Tucker - Torrance A. S. Amatangelo - Cary G. L. Miller - Cary W. P. Miller - Cary April 19, 1985 Community Hazard Communication Here is additional information to support Community Hazard Communication. 1. A list of chemicals on inventory at Cary which we believe meet the OSHA Definition of Hazardous, prepared by W. P. Miller. 2. A list of Latex products which may be considered hazardous because they may contain carcinogens in excess of 0.1 percent. 3. A guideline from J. A. Leonard which breaks the various OSHA Hazard Category definitions down and makes hazard determination easier. 4. A National Safety Council listing of hazardous chemicals. 5. A copy of the OSHA Hazard Communication Standard. More information will follow. Attachment 0295A Regards, M V. D. Dutcher 7 86 HAZARDOUS SUBSTANCES CARY INVENTORY Greater than one gallon or 10 lbs. Acids and Bases Acetic Acid Hydrochloric Acid Sulfuric Acid Pyridine 4 (p-nitrobenzyl) pyridine Ammonium Hydroxide Sodium Hydroxide Cycat 4040 pH 10 Buffer Dimethylaminoethanol Polyglycolamine H-221 Triethylene pentamine Oxidizinq/Reducinq Agents tert-Butyl Hydroperoxide tert-3utyl Peroxybenzoate Hydrogen Peroxide Sodium Sulfite Ammonium Persulfate Sodium Persulfate Potassium Persulfate t-Amyl Hydroperoxide Lupersol 575-M75 Lupersol 533-M75 Lupersol 531-80M Sodium Metabisulfite Hydrcsulfite A WC Sodium Formaldehyde Sylfoxylate Thiox Monomers Propylenimine Acrylonitrile 2-Hydroxyethyl Acrylate Butyl Acrylate Acrylic Acid Methacrylic Acid Hydroxypropyl Acrylate Vinyl Acetate Trimethylolpropane Triacrylate 2-Ethylhexyl Acrylate Methyl Methacrylate Styrene Vinyl Chloride (Cylinders) Vinylidene Chloride 81-007 DeSoto D. Solvents * Methyl Ethyl Ketone * Toluene Phenyl Glycol Ether * Acetone N. N. -Dimethyl formami.de * Ethylene Glycol * Isopropyl Alcohol * Propasol Solvent P * Propasol Solvent B Methyl Sulfoxide * Propylene Glycol * Mineral Spirits * Methanol * Butyl CELLOSOLVE E. Preservatives Proxel GX2 Kathon LX (1095) Nuosept 95 Cosan 101 LP Troysan Polyphase AF-1 Cosan 145 Troysan 364 Vancide 51Z Amerstat 251 Troysan PMA-30 Troysan 192 Skane M-8 2 3 F . 5urfactants/Pispersants/flntifoams/Thickeners Triton GR-5M Triton GR-7M Drewplus L-414 Abex JKB Trem LF40 Chemax EPX-570 Chemax EPX-571 Triton X-102 Triton X-202 Triton X-100 Triton X-301 Triton N-57 Triton N-101 Abex JKB Zonyl FSC Aerosol TR 70% Byk 070 * Bykumen Byk 020 Byk 065 * Aerosol OT (75%) Laetimon WC * TERGITOL NP-10 * TERGITOL NP-4 Patcote 577 Patcote 519 Patcote 512 Patcote 513 Patcote 847 Drewplus 240 Nopco ND W Triton X-101 Triton QS-44 Triton QS-30 Strodex PK 80A Polystep A4 Polystep RA-35S * Potassium Oleate Byk 341 Byk 321 Byk 301 Drewgard 432 * Hydroxyethyl Cellulose Methocei 228 Dowfax 2A1 Aerosol C-61 * SCT Thickener A23 1 83 4 G. Pigments Antimonic Oxide * Mica * Silica * Talc (Non-Asbestos) * Talc (Fibrous) * Titanium Dioxide * Zinc Chromate * Strontium Chromate * Calcium Carbonate (Limestone) * Zinc Oxide * Barium Metaborate Manganese Oxide Molydate Orange Carbon Black * Halox Pigments (Calcium Silicates) * Oncor M-50 * Chrome Oxide Green * Barium Chromate H. Miscellaneous Syn-O-Ad 8484 LA/LW Bromotrichloromethane Butyl Mercaptan Fyrarestov 330 Paroil 170-8 Chlorowax 40 Oicyclohexyl Slip-Ayd SL-523 Cymel 327 Resimene 717 Nuocure CK 10* Cymel 370 Cymel 380 Nuocune Calcium 6* Nuocure Manganese 6* Intercar Zinco 12* Intercar Manganese 6* * QP 8-5314 Intermediate Flat-Ayd W-34 Dapro DF-880 Slip-Ayd SL-18 Dapro W-77 Dapro DF-1181 Dapro DF-944 Dapro OF-900 A 0V r ^ ^ 5 H. Miscellaneous (continued) Slip Ayd S2-404 Slip Ayd SL295A Nuocure Zirconium 12% Nuocure Cobalt 10% Intercar Calcium 6% Ferrous Sulfate * Cymel 325 * Hysol Mold Release * CoVe Base Adhesive I. Compressed Gases and Liquids Air * Nitrogen Helium Hydrogen * Halon Fire Extinguishers a 2 3 : < 6 The following products may be considered hazardous mixtures because they contain carcinogens above O.lfc according to their MSDS or EPSOS. UCAR Latex BX-3001 UCAR Latex 828 UCAR Latex 163 UCAR Latex 872 UCAR Latex 154 UCAR Latex 874 UCAR Latex 153 UCAR Latex 879 UCAR Latex 336 UCAR Latex 442 UCAR Latex 828 UCAR Latex 803 UCAR Latex BX-3148 UCAR Latex BX-3178 UCAR Vehicl e 4550 The following products, probably obsolete, also would be considered hazardous mixtures for the same reason. UCAR Latex BX-3003 UCAR Latex 3X-3006 UCAR Latex ICX-7113 UCAR Latex SX-3550 UCAR Latex 171 UCAR Latex 189 UCAR Latex 822 UCAR Latex 878 UCAR Latex 152 UCAR Latex 177 0295A A23 1 92 11/27/84 } A Leonard HOW 70 DCTCRMNC IF PRODUCT IS HAZARDOUS 1 ] What chemical* ane in. the. product at .1% on greater ?(Weight on. volume) 2] Lualuate each component in the pnoduct u*ing Hazardou* Determination criteria. 3] All quettion* ane intended to He u*ed to evaluate materials pne*ent at 1% on gneuter in the pnoduct. 4] Question numJLer 1 mart alto le ured to evaluate material* present at . 1% toll. 5J 1/ a material It prerent lelow 1%, on in the care of a carcinogen, let* than . 7% , lot could le neleared at concentration* greater than the 7LV (PIL) then the hazard ir preturned pnetent in the pnoduct. WHAT TO DO WITH 7HC INFORMATION............. 1 ] Prepare a lid of hazardous chemical*. 2] Prepare an USDS /.on hazardous chemical* leing manufactured. 3] Collect an USDS for all hazandou* chemical* leing u*ed. 7970. 7200 Hazard Communication.-j Hazard Determination Criteria (all component/) 7% or greater- ail gue/>t/.on4) 7J I* the material carcinogenic ? (u/>e thti, criteria /on alt component/) o/ the product inconcentnatioru, o/ .7% or more ly ut. or vol. ) Criteria: ' Carcinogen: A chemical U considered to be a carcinogen il: (a) It bas been evaluated by the International Agency for Research on Cancer (1ARC). and found to be a carcinogen or potential carcinogen: or (b) It it listed as a carcinogen or potential carcinogen in the Annual Report on Carcinogens published by the National Toxicology Program (NTPJ (latest edition): or. (c) Il is regulated by OSHA as a carcinogen. 2] l/> tjxe material corrosive ? 3 ] I/> the material heghly toxec ? Criteria: Corrosive: A chemical that causes visible destruction of. or irreversible alterations in. living tissue by chemical action at the site of contact. For example, a chemical is considered to be corrosive if. when tested on the intact skin of albino rabbits by the method described by the U.S. Department of Transportation in Appendix A to 49 CFR . Part 173. il destroys or changes irreversibly the structure of the tissue at the site of contact following an exposure period of four hours. This term shall not refer to action on inanimate aurfacei. Criteria: i Highly toxic A chemical falling i within any of the following categories: f (a) A chemical that has a median lethal dose (LDm) of 50 milligrams or less per kilogram of body weight when administered orally to albino rata weighing between 200 and 300 grama each. (b) A chemical that has a median lethal dose (LDm) of 200 milligrams or less per kilogram of body weight when I administered by continuous contact for 24 hours (or less if death occurs within 24 hours) with the bare akin of albino rabbits weighing between two and three kilograms each. (c) A chemical that has a median I lethal concentration (LCm) in air of 200 parts per million by volume or less of j gas or vapor, or 2 milligrams per liter or i lest of mist. fume, or dust, when iy O 3 1 Q|3,(^niniJlered by continuous inhalation ^ I for one hour for less if death occurs ! within one hour) to albino rats weighing between 200 and 300 grams each. (t R) 4] IS the. mnionJnl an jsmltafuL ? 5 ] l/> the. mateJUjaJL a AeJi&IHzA. ? CjiII&aJji: Irritant- A chemical, which ia not corrosive, but which causes a reversible inflammatory effect on living tissue by chemical action at the site of contact. A \ chemical it a skin Irritant if, when tested on the intact skin of albino rabbits by the methods of 16 CFR 1500.41 for four hours exposure or by other appropriate techniques, it results in an empirical core of five or more. A chemical is an eye irritant if so determined under the procedure listed in 16 CFR 1500.42 or other appropriate techniques. OUteAlxL: Sensitizer A chemical that causes a substantia! proportion of exposed : people or animals to develop an allergic ' reaction in normal tissue after repeated | exposure to the chemical. 6] It the. matejujaJt toxic ? CaJJLzaIju.: Tox/c. A chemical falling within any of the following categories: (a) A chemical that bas a median ii lethal dose (LD*) of more than 50 milligrams per kilogram but not more than 500 milligrams per kilogram of body weight when administered orally il to albino rats weighing between 200 and 900 grams each. tt (b) A chemical that has a median lethal dose (LDw) of more than 200 {i milligrams per kilogram but not more i than 1,000 milligrams per kilogram of body weight when administered by continuous contact for 24 hours (or lest l If death occurs within 24 hours) with the bare akin of albino rabbits weighing between two and three kilograms each. (c) A chemical that has a median lethal concentration (LC m) in air of more than 200 parts per million but not more than 2.000 parts per million by t i volume of gas or vapor, two milligrams per liter or more than but not more than 20 milligrams per liter of mist, fume, or dust, when administered by continuous inhalation for one hour (or leas if death occur* within one hour) to albino rata weighing between 200 and 900 grams each. A23194 m 7 ] Doe-t, the matesLiaJL demorviteate tcuigei. oegan efjec&> ? Cnudesita.: Target organ effects. The following 1* a target organ categorization of effect* which may occur, including examples of signs and symptom and chemicals which have been found to cause such effects. These examples are presented to illustrate the range and diversity of effects and hazards found in the workplace, and the broad scope employers must consider in this area, but are not intended to be alhinclusivc. fc. Oamaqa 9m Ibrigtgna *r: Synptorm hmroi. Sqm am - K Ef* huaret . Carton mone)i. cyvidn 0mc Ocf' ntM or A . Co<r% >gf>teii n owe, gti Immtt O0CP. . Omrmcat rfWe: tm OarmM toyv 0 9m tc0r ' CMar^ of N />. nra O^mc I 8] Ii the maLentat acomAu^txJLte tiguMl ? 9] Ia> the mntfjiJnf a compnjeA4ed. gcu> ? 10] 14 the. matjentat an expto^tve ? | } i' j * CsisiLcnJ-a: "Combustible liquid" meant any liquid having a flashpoint at or above 100"F (37.6'C). but below 200`F (93.3'C). except any mixture having component! with flashpoint! of 200'F (83.3'C). or higher, the total volume of which make up 99 percent or more of the total volume of the mixture. C/ittenta: "Compressed gai" meant: (i) A gas or mixture of gases having, in a container, an absolute pressure exceeding 40 psi at 70'F (21.VC): or (ii) A gas or mixture of gases having, in a container, an absolute pressure exceeding 104 psi at 130'F (S4.4*C) regardless of the pressure at 70'F (21.1 *CJ: or (sis) A liquid having a vapor pressure exceeding 40 psi at 100`F (37J'C) as determined by ASTM I>-323-72. Cnitenxa: "Explosive" means a chemical that causes a sudden, almost instantaneous ; release of pressure, gas. and heat when subjected to sudden shock, pressure, or high temperature. 77 ] 14 the matental flxmmaJLLe ? OULenta: "Flammable" means a chemical that j (iii) "Liquid, flammable" means any falls into one of the following categories: | liquid having a flashpoint below 100'F (i) "Aerosol, flammable" means an j (37.6`C). except any mixture having aerosol thst. when tested by the method components with flashpoints of 100*F described in 16 CFR 1500.45. yields a ' (37.6'C) or higher, the total of which flame projection exceeding 16 inches at make up 99 percent or more of the total full valve opening, or a flashback (a Dame extending back to the valve) at volume of the mixture. ! (iv) "Solid, flammable" means a solid. any degree of valve opening: ] other than a blasting agent or explosive (ii) "Cat. flammable" means: ' as defined in f 1910.109(a). that is liable (A) A gas that, at ambient to cause fire through friction, absorption temperature and pressure, forms a of moisture, spontaneous chemical flammable mixture with sir at a j change, or retained beat from concentration of thirteen (13) percent by manufacturing or processing, or which volume or less; or can be ignited readily and when ignited (B) A gas that, at ambient temperature bums so vigorously and persistently as and pressure, forms a range of ! to oeete a serious hazard. A chemical flammable mixtures with air wider than twelve (12) percent by volume, regardless of the lower limit: shall be considered to be a flammable %' sd If. when tested by the method escribed in 16 CFR 1500.44. It ignites and bums with s self-sustained flame at a rate greater than one-tenth of an inch 1 per second along its major axis. [ 57 72/ iAe maJjenJjal. an onganic pesioxljde ? 73] Ia the matenlxut an oxidize* ? 14] Ia the madenlal py/iophonlc ? Cndtenla: "Organic peroxide" Beam an organic compound that contains the bivalent -O O-structuie and which may be cooiidered to be a structural derivative . of hydrogen peroxide where one or both ! of the hydrogen atomi hat been ! replaced by an organic radical. cndtenla: "Oxidizer" meant a chemical other than a blaiting agent or explosive at j defined in 1 lffl0.109(a). that initiates or promotes combustion in other materials. | thereby causing fire either of itself or 1 through the release of oxygen or other ! gases. Cnlienia: j "Pyrophoric" meant a chemical that will ignite spontaneously in air at a temperature of 130` F (54.<* CJ or below. 73] IA the mcitenunt un^inC.ft>(nonriJtio ) ? 16] 1a the matenuzii. loaden-zieacilue ? Oudejuja: "Unstable (reactive)" meant a ' chemical which in the pure state, or as produced or transported, will vigorously polymerize, decompose, condense, or will become self-reactive under , conditions of shocks pressure or ' temperature. Csiitenda.: "Water-reactive" means a chemical that reacts with water to release a gas ' that is either flammable or presents a health hazard. 17] Aa. the/ue any athe/i knoun hazandA Algnl./LicJjanl enough to Include ? Cnitenla: Adequacy and reporting ofdata: The results of any studies which are designed and conducted according to established scientific principles, and which report statistically significant conclusions regarding the health effects of a chemical, shall be a sufficient basis for a hazard determination and reported on any material safety data sheet. The chemical manufacturer, importer, or employer may also report the results of other scientifically valid studies which tend to refute the findings of hazard. A23 <"? 16] 18] Ton matenlruLi> LLiixd -in. a] 29 CTR 7910 SufLpant Z t) ACQIH (latent) : The. maiendjuL -Lt> e^,taJLLbhed cu> tvizandou* and the hazand mutt e evafuated iu>ing the cnJJLenda In guez.td.oru, 1-17. The chemical manufacturer, importer or employer evaluating chemical* aha11 treat the following aourcet a* establishing that the chemical* lilted in them are hazardous: (i) 29 Cnt Part mo. Subpart 2. Toxic and Hazardou* Substances. Occupational Safety and Health Administration (OSHA); or. (ii) Threshold Limit Values for Chemical Substances and Physical Agents in the Work Environment. American Conference of Governmental Industrial Hygienists (ACGIH) (latest edition). Tbe chemical manufacturer, importer, or employer is still responsible for evaluating the hazard* associated with the chemicals in these source lists in accordance with the requirements of the standard. > A23 1 GC ifr ATTACHMENT I HA7.AF.D0US CHEMICAL CLASSIFICATION' GUIDE (FOR USE ir COMPLYING WITH OSHA HA7.ARD COMMUNICATION' STANDARD. 29 CFR 1910.1200? SU3STANCE/PROCESSOSHA Acetaldehyde Acetic acid Acetic anhydride Acetone Acetonitrile . 2-Acetylaminofluorene Acetylene 2-Acetylaminofiuorene Acetylene dichloride, 6ee 1, 2-DlchloroethyIene Acetylene tetrabromide Acetylselicylic acid (Asprin) Acrolein Acrylamide Acrylic acid Acrylonitrile Ad riamycin Afietosins Aldrin Allyl alcohol Allvl chloride Allyl glycidyl'ether (ACE) Allyl propyl disulfide alpha-Aiumina Aluminum ~ Hetal & oxide Pyro powders Welding fumes Soluble salts Alkyls (NOC) 2-Aminoanthraquinone o-Aminoasctoluene 4-Aminobiphenyl, see 4-Aminodiphenjl 4-Aminodiphenyl 2-Aminoethanol, see Ethanolamine 1-Amino-2-methylanthraquinone 2-Aninopyridine 2-Amino-S(5-nitro-2-furyl)-l ,3,4-thiadiazole 3-Amino 1, 2, 4-triazole, see Amitrole Ami trole Ammonia Ammonium chloride fume Ammonium sulfamate (Ammate) n-Amyl acetate 6ec-Aayl acetate X X X X X X X X X X X X X X X X X X X X X SOURCE11 ACGIH X X X X X X NTP X X X X X X XX X X X X X X X X X X X X X X XX X X XX X X X X X I ARC X X X X X X X Prepared by: Chemical Section Committee i National Safety Council May,198^ A 2 3 i oT10 HAZARDOUS CHEMICAL CLASSIFICATION G'JT.DE (FOR USE IN COMPLYING WITH OSHA HAZARD COMMUNICATION STANDARD. 29 CFR 1910.1200) SUBSTANCE/PROCESS________________________ Aniline & homologues Anisidine (o-,p-i6omer6) o-Ani8idine o-Anisidine hydrochloride Antimony A compounds, as Sh Antimony trioxide Handling end use, as Sb Production ANTU (alpha naphthyl thiourea) Aramite Argon Arsenic A soluble compounds, as As Arsenic trioxide production Arsine Asbestos, also see MINERAL DUSTS, page 22 Asphalt (petroleum) fumeG Atrazine Auramine manufacture Aza6erine Azinphosmethyl (Guthion) Barium, soluble compounds, as Ba BCNU (bischloroethyl nitrosourea) Benomyl Benz(a)anthracene Benzene Benzidine p-Benzoquinone, see Quinone Benzo(b)fluoranthene Benzo(a)pyrene Benzoyl peroxide Benzotrrchloride Benzyl chloride Benzyl violet 4B Beryllium end beryllium compounds Biphenyl, see Diphenyl Bismuth telluride Se-doped Borates, tetra, sodium salts. Anhydrous Decahydrate Pentahydrate Boron oxide Boron tribromide Boron trifluoride 2 OSHA X X X X X X X X X X X X X X X X SOURCE* ACGTH X X X X X X X X X X X X X X NTP X X X X X X X X X X XX XX X XX X X XX X X X X X X X X X 1 ARC X X X X X X X X X X X X 00010 A232CC HAZARDOUS CHEMICAL CLASSIFICATION GUIDE (FOR USE IK COMPLYING UITH OSHA HAZARD COMMUNICATION' STANDARD. 29 CFR 1910.1200) SUBSTAWCS/PROCPSS Bromacil Bromine Bromine pentafluoride Bromochloromethane, see Chlorobromomethane Bromoform 1,3-Butadiene Butane Butanethiol, see Butyl mercaptan 2-Butanone, see Hethyl ethyl ketone (KEK) 2-Butoxyethanol (Butyl Cellosolve) n-Butyl acetate sec-Butyl acetate tert-Butyl acetate Butyl acrylate n-Butyl alcohol 6ec-Butyl alcohol tert-Butyl alcohol Butylamine tert-Butyl chromate, as Cr03 n-Butyl jlycidyl ether (BGE) i-Butyl lactate Jutyl mercaptan (Butanethiol) alpha-sec-Butylphenol p-tert-Butyltoluene be ta-Butyrolactone Cadmium Dust & salts, as Cd Cadmium Chloride Cadmium oxide Fume, as Cd Production Cadmium sulfate Cadmium sulfide Calcium carbonate/marble Calcium chromate Calcium cyanamide Calcium hydroxide Calcium oxide Calcium silicate Camphor, synthetic Caprolactam Dust Vapor Captafol Captan OSHA X X X source:*________________ ACGIH NIP_______ IAC X X X X X X XX XX XX XX X XX XX XX XX XX XX X XX X XX X XX X XX X X XX XX X X X XX X XX X X X X X 3 00010 A2320 1 HA-iShDHg CHEHTCAr. rt.ABnrPTCATTOV CUTUP. (FOR use TK COMPLYING UITHOSKA hazarp COKMUN I CAT I ON' STANDARD. 29 CPR 19.10 .,1200-) SOURCE* SUBSTANCE/PROCESS OS HA ACGIH Carbaryl (Sevin) Carbofuran XX X Carbon black XX Carbon dioxide Carbon disulfide XX XX Carbon monoxide XX Carbon tetrabromide Carbon tetrachloride X XX Carbonyl chloride, see Phosgene Carbonyl fluoride Catechol (Pyrocatechol) X X CCNU (1-(2-Chloroethyl)-3cylcohexyl-l-nitrosourea) Cellulose (paper fiber) X Cesium hydroxide Chlorambucil X Chlordane Chlordecone, see Kepone XX Chlorinated camphene Chlorinated diphenyl oxide Chlorine Chlorine dioxide Chlorine trifluoride Chlornaphazine XX XX _ XX XX XX Chloroacetaldehyde elpha-Chloroacetophenone (Phenacyl chloride) Chloroacetyl chloride Chlorobenzene (Monochlorobenzene) o-Chlorobenzylidene malononitrile (OCBM) Chlorobromomethane (Bromochloromethane) XX XX X XX XX XX 2-Chloro-l,3-butadine, Bee B-Chloroprene Chlorodifluoromethane 1-Chloro, 2, 3-epoxy-propane, 6ee Epichlorohydrin 2-Chloroethanol, see Ethylene chlorohydrin X N, N-bis (2-chloroethyl)-2-naphthylamine, see Chlornaphazine Chloroethylene, see Vinyl chloride Chloroform (trichlororaethane) bis-Chloromethyl ether Chloromethyl methyl ether, technical grade 1-Chloro-l-nitropropane Chlorooentafluoroethane 4-Chloro-o-phenylenediamine XX XX ( X XX X Chloropicrin (nitrotrichlororaethane) B-Chloroprene (2-chloro-l,3-butadiene) o-Chlorostyrene XX XX X NIP X X X X X X X 1 ARC X X X X X X X X A OOOIO A 2320? HAZARDOUS CHEMICAL CLASSIFICATION GUIDE (FOR USE IN COMPLYING WITH OSHA HAZARD COMMUNICATION STANDARD. 79 CFR 1910.1200) SUBSTANCE/PROCESS OSHA o-Chlorotoluene 2-Chloro-6-(trichloromethyl) pyridine, see Nitrapyrin Chlorpyrifos Chromic acid and chromates Chromite ore processing (Chromate), as Cr X Chromium Ketal X Chromium (II) compounds, as Cr Chromium (III) compounds, as Cr X X Chromium (VI) compounds, e6 Cr Water soluble Certain water insoluble X X X Chromyl chloride Chrysene Citrus Red No. 2 Clopidol Coal dust, see MINERAL DUSTS, page 22 Coal ter pitch volatiles (as benzene soluble fractions; anthracene. X BaP, phenanthrene, acridine, chrysene , pyrene) Cobalt, as Co metal, dust & fume Cobalt carbonyl, as Co X Cobalt hydrocarbonyl, as Co > Coke oven emissions Copper X Fume Dusts & mist6, as Cu Cotton dust, raw X X X Crag herbicide p-Cresidine X Cre6ol,- all isomeres Crotonaldehyde Crufomate X X Cumene Cupferron . Cyanamide X Cyanides, as CN Cyanogen Cyanogen chloride X Cycasin Cyclohexane Cyclohexanol Cyclohexanone Cyclohexene Cyclohexyl amine X X X X SOURCE* ACGIH NTP X X X X XX XX XX XX XX XX X X X X TARC X X X X X X X X XX X X X X X X X X X XX X X X X X 5 00010 A 2 32 r 0 ^ .i HAZARDOUS CKEKICAL CLASSIFICATION1 GUIDE (FOR USE IK COMPLYING WITH OSHA KA2ARD COKMUKICATTO.V STANDARD. ?9 CFR 1910.1200? SUBSTAJ.'CS/PROCESS______________________________________ OSHA Cyclonite Cyclopentadiene Cyclopentane Cyclophosphamide Cyhexatin 2.4-D DDT (Dichlorodiphenyltrichloroethane) DDVP . Dacarbazine Daunomycin Decaborane Demeton Diacetone alcohol (4-hydroxy-4methyl-2-pentanone) N,N'-Diacetylbenzidine 2.4-Diaminoar.isole sulfate 4,4'-Diami nod:phenyl ether 1,2-Dieminoethane , see Ethylenediamine 2.4-Diaminotcluene Diazinon Diazomethane " Dibenz (a,h) acridine Dibenz (a,j) acridine Dibenz (a.h) anthracene 7H-Dibenzo (c,g) carbazole Dibenzo (e,e) pyrene Dibenzo (a.h) pyrene Dibenzo (a.i) pyrene Diborane 1.2 Dibromo-3-Chloropropane 1.2- Dibromoethane, see Ethylene dibromide 2-H-Dibutylaminoethanol Dibutyl phosphate 'Dibutyl phthalate Dichloroacetylene o-Dichlorobenzene p-Dichlorobenzene 3.3'-Dichlorobenzidine (and its 6alt6) 3,3'-Dichloro-4 ,4'-diareinodiphenyl ether Dichlorodifluoromethane 1.3- Dichloro-5.5-dimethyl hydantoin 1.1- Dichloroethane (Ethylidene chloride) 1.2- Dichloroethane , see Ethylene dichloride 1.1- Dichloroethylene, see Vinylidene chloride 1.2- Dichloroethylene (Acetylenedichloride) X X X X X X X X X X X X X X X X X X X SOURCE8 ACGIH KIP X X X X X X X X X IARC X X X X X X X X x * K K X K X KK X XX X X X X X X X XX X X X X X 6 A2 t 00010 HAZARDOUS CHEMICAL CLASSIFICATION GUIDE (FOR USE IN COMPLYING WITH OSHA HAZARD COMMUNICATION STANDARD. 29 CFR 1910.1200) SOURCE* SUBSTANCE/PROCESS OSHA ACGIH Dichloroethyl ether XX Dichlorofluoromethane X Dichloromethane, see Methylene chloride Dichloromonofluoromethane 1.1-Dichloro-l-nitroethane ` X XX 1.2-Dichloropropane, see Propylene dichloride Dichloropropene 2.2-Dichloropropionic acid , X X Dichlorotetrafluoroethane XX Dichlorvos Dicrctophos X X Dicyclopentadiene X Dicvcloper.tadienyl iron Dieldrin X XX Diepoxybutene Diethanololemine X Diethylamine Diethyleminoethanol XX XX Diethylene triamine Diethyl ether, see Ethyl ether X Di (2-ethylhexyl) phthalate 1.2-Diethylhvdrazine Diethyl ketone X Diethyl phthalate X Diethylstilbestrol Diethyl sulfate Difluorodibromomethene XX Diglycidyl ether <DGE) XX Dihydroxybenzene, see Hydroquinone Dihydrosafrole Di isobutyl ketone <2,6-Dimethyl-4-heptanone) Di isopropylamine XX XX 3. 3*-Dimethoxybenzidine (o-Dianisidine) Dimethoxymethane, see Methylal Dimethyl acetamide XX Dimethylamine XX p-Dimethylaminoazobenzene Dimethylaminobemene. see Xylidene trans-2 C(Dime thy1amino)methy1imino]-5-12-(5-nitro-2-f uryl)vinyl]- 1,3,4-oxadiaaole Dimethylaniline (N, N-Dimethylaniline) XX Dimethvlber.cene, see Xylene 3.3'-Dimethylbenzidine (o-Tolidine) Dimethyl carbamyl chloride X Dime thy1-1,2-dibromo-2-dichloroethyl phosphate, See Naled (Dibron) A2320b 7 NTP X X X x xx xx x * xx I ARC 00010 HAZARDOUS CHEMICAL CLASSIFICATION GUIDE (FOR USE IK COMPLYING WITH OSHA HAZARD COMMUNICATION STANDARD. ?9 CFR 1910-1200? SUBSTANCE/PROCESS Dimethylf ormajnide 2,6-Dimethyl-4-heptanone, see Dii6obutyl ketone 1,1-Dimethylhydrazine 1,2-Dimethylhydrazine Dimethylphthalate Dimethyl sulfate Dinitolmide (3,5-Dinitro-o-toluamide) Dinitrobenzene (all isomers) Dinitro-o-cresol 3,5-Dinitro-o-toluamide, see Dinitolmide Dinitrotoluene 1,4-Dioxane, tech, grade (Diethylene dioxide) Dioxathion Diphenyl (Biphenyl) Diphenylemine Diphenylmethane diisocyanate, See Methylene bisphenyl isocyanate (MDI) Dipropylene glycol methyl ether Dipropyl ketone Diquat Direct Black 33 Direct Blue 6 Di-sec, octyl phthalate (Di-Z-ethylhexylphthalate) Disulfiram Disulfoton 2,6-Ditert. butyl-p-cresol Diuron Divinyl benzene Emery Endosulfan Endrin Epichlorohydrin (1-Chloro,2,3-epoxy-propane) EPN 1.2-Epoxypropane, see Propylene oxide 2.3-Epoxy-l-propanol, see Glycidol Ethane Ethanethiol, see Ethyl mercaptan Ethanolamine (2-Aminoethanol) Ethinyloestradiol Ethion 2-Ethoxyethanol (Glycol monoethyl ether) 2-Ethoxyethyl acetate (cellosolve acetate) OSHA X X X X X X X X X X X X X X . ' X X X SOURCE* ACGIH X NIP X X XX X X X X XX X X X 1 ARC X X X X X X X XX XX X X X X X X X X X XX X X X X X X X 8 000 io A23206 HA~Ar.DOUS CHEMICAL CLASSIFICATION GUIDE (FOR USE IK COMPLYING WITH OSHA HAZARD COHyjN'I CATION STANDARD. 29 CFR 1910.1200) 5HBSTANCE/PR0CF.SS Ethyl acetate Ethyl acrylate Ethyl alcohol (Ethanol) Ethylamine Ethyl amyl ketone (5-methyl-3-het>tanone) Ethyl benzene Ethyl bromide Ethyl butyl ketone (3-heptanone), Ethyl chloride Ethylene Ethylene chlorohydrin (2 Chloroethanol) Ethyienediamine (1,2 Diaminoethane) Ethylene dibromide (1,2 Dibromoethane) Ethylene dichloride (1,2 Dichloroethane) Ethylene glycol Perticulate Vapor Ethylene glycol dinitrate and/or Nitroglycerin Ethylene glycol methyl ether acetate, see 2-Kethoxyethyl acetate Ethylene oxide Ethyleneimine Ethylene thiourea Ethyl ether (Diethyl ether) Ethyl formate Ethvlidene chloride, see 1,1-Dichloroethane Ethylidene norbornene Ethyl mercaptan (Ethanethiol) Ethyl methanesulfonate N-Ethylmorpholine Ethyl silicate Pensulfothion Fenthion Ferbam Ferrovanadium dust Fibrous glass dust (Glass, fibrous or du5t) Fluorides, as F Fluorine Fluorotrichloromethane, see Trichlorofluoromethane Fonofos Formaldehyde Formaldehyde gas Formamide OSHA X X X X X X X X X X X X X X X X X X X X X X X X `X source:* ACGIH X X X X X X X X X X X X X X X X X N'7P X X TARC X X X X XX X X X X X X X X X X X X X X X X XX X X 9 00010 A2320? HAZARDOUS CHEMICAL CLASSIrICATION GUIDE (FOR USE If.' COMPLYING WITH OSHA HAZARD COMMUNICATION STANDARD. 29 CFR 1910.1200) SUBSTANCE/PROCESSOSHA Formic acid 2-(2-Formylhydrazino)-4-( 5-nitro-2-fury1)thiazole Furfural Furfuryl alcohol Gasoline Germanium tetrahydride Glass, fibrous or dust, see Fibrous glass dust Glutaraldehyde Glycerin mist Glycidaldehyde Glycidol (2,3-Epoxy-l-propanol) Glycol monoethyl ether, see 2-Ethoxyethanol Graphite (Natural), see MINERAL DUSTS. page 22 Graphite (Synthetic) Guthion, see Azinphosmethyl Gypsum Hafnium Helium Hematite underground mining Heptachlor Heptane (n-Keptane) 2-Heptenone, see Methyl n-aroyl ketone 3-Heptanone, see Ethyl butyl ketone Hexachlorobenzene Hexachlorobutadiene Hexachlorocyclohexane isomers Hexachlorocyclopentadiene Hexachloroethane Hexachloronophthalene HexafluoroacetoneHexamethyl phosphoramide Hexane (n-Hexane) Other isomers 2-Hexanone,Tsee Methyl n-butyl ketone Hexone, see Methyl isobutyl ketone sec-Kexyl acetate Hexylene glycol Hydrazine Hydrazine sulfate Hydrazobenzene Hydrogen Hydrogenated terphenyls Hydrogen bromide Hydrogen chloride X X X X X X X X X X X -x ' X X SOURCE* ACGIH X NTP X X X X X X X 1ARC X X X X X X X X X XX X X X X X X XX X X X X X XX X X X X X X I l A 2 3 2C0CB 1 HA7.AF.DS'J5 CHEMICAL CLASSIFICATION' GUIDE (FOR USE IN COMPLYING WITH OSHA HAZARD CPKyUKTCATIO?.' STANDARD. 29 CFR 1910.1200) SUBSTANCE/PROCESS Hydrogen cyanide Hydrogen fluoride, as F Hydrogen peroxide Hydrogen selenide, as Se Hydrogen sulfide Hydroauinone (Dihydroxybenaene) 4-Hydroxy-4-methyl-2-pentanone, see Diacetone alcohol 2-Hydroxypropyl acrylate Indene Indeno (1,2-cd) pyrene Indeno (1,2,3-cd) pyrene Indium & compounds, as Tn Inert (nuisance) dust, see MINERAL Iodine Iodoform Iron dextran complex Iron oxide fume (FejOj), as Fe Iron pentecarbonyl, as Fe Iron salts, soluble, as Fe l6oamyl acetate l6oamyl alcohol Isobutyl acetate Isobutyl alcohol Isooctyl alcohol Isophorone Isophorone diisocyanate Isopropoxvethanol Isopropyl acetate Isopropyl alcohol l6opropylamine Manufacture (strong-acid process) N-Isopropylaniline Isopropyl ether Isopropyl glycidyl ether (ICE) Isosafrole Kao)in Kepone (Chlordecone) Ketene tLas>locarpine Lead, inorg., dusts & fumes, as Pb Lead acetate Lead arsenate, as Pb3(AsO*)2 Lead chromate, as Cr DUSTS, page - 22 OSHA X X X X X X X x X X X X X X X X X A x SOURCE* ACGIH KTP X X X X X X X X TAP.C X X XX X X X X X X X X X X X X X X X X X X X X XX X X X XX X XX 11 00010 A23209 HAZARDOUS CHEMICAL CLASSIFICATION' GUIDE (FOR USE IK COMPLYING UITH OSHA HAZARD COMMUMCATTO,1,' STAKDARD, 29 CFR 1910.1200) SUBSTAKCE/FROCESS Lead phosphate Lead 6ubacelate Limestone Lindane Lithium hydride L.P.G. .(Liouified petroleum gas) Magnesite Magnesium oxide fume Malathion Maleic anhydride Manganese, as Mr; Dust & compounds Fume Manganese cyclopentadienyl tricarbonyl, as Kn Manganese tetroxide Karble/calcium carbonate Melphalan Mercury, as Hg; Alkyl compounds All forms except alkyl; Vapor Aryl & inorganic compounds Merphalan Mesityl oxide Mestrenol Methacrylic acid Methane Methanethiol, 6ee Hethyl mercaptan - Kethomyl Methoxsalen with ultra-violet A therapy (PUVA) Methoxychlor 2-Methoxyethanol, see Methyl cellosolve 2-Methoxyethyl acetate (Ethylene glycol methyl ether acetate) 4-Hethoxyphenol Methyl acetate Methyl acetylene (propyne) Methyl acetylene-propadiene Methyl acrylate Methylacrylonitrile Methylal (Dimethoxymethane) Methyl alcohol (methanol) mixture (MAPP) Methylamine Methyl amyl alcohol, see Methyl isobutyl carbinol Methyl n-amyl ketone (2-Heptanone) N-Methyl aniline 2-Hethylaziridine Methylazoxymethanol and its acetate OSHA x X X X X X X X X X X X X X X X X X X X 12 SOURCE* ACCIH NTP X X XX X X X X X X X X X X X X X X X X X X X X 1 ARC X X X X X X X X X X X X X X X X X X KX 00010 A232 1 C HAZARDOUS CHEMICAL CLASSIFICATION' GUIDE (FOR USE IK COMPLYING WITH OSHA HAZARD COMMUNICATION STANDARD. 29 CPR 1910.1200)' SUBSTANCE/PROCESS________________________________________ OSHA Methyl bromide Methyl n-butyl ketone (2-Hexanone) Methyl cellosolve (2-Hethoxyethanol) Methyl cellosolve acetate Methyl chloride ' Methyl chloromethyl ether Methyl chloroform Methyl 2-cyanoacrylate Methylcyclohexane Methylcvclohexanol o-Methylcyclohexanone Hethylcyclopentadienyl manganese tricarbonyl, as Hn Methyl demeton Methylene bisphenyl isocyanate (MDI) (Diphenyl methane diisocyanate) Methylene chloride (Dichloromethane) 4,4'-Methylene bis (2-chloroaniline) (MOCA) Methylene bis (4-cyclohexylisocyanate) 4,4'-Methylene bis (N,N-dimethyl) benaenamine 4,4'-Hethylene bis (2-methylaniline) 4,4-Hethylene dianiline ' Methyl ethyl ketone (MEK) (2-Butanone) Methyl ethyl ketone peroxide Methyl formate 5-Methyl-3-heptanone, see Ethyl amyl ketone Methyl hydrazine Methyl iodide " Methyl isoamyi ketone Methyl isobutyl carbinol (Methyl amyl alcohol) Methyl isobutyl ketone (KIBK) (Hexone) Methyl isocyanate Methyl isopropyl ketone Methyl mercaptan (Methanethiol) Methyl methacrylate Methyl methanesulfonate 2-Methyl-l-nitroanthraquinone (of uncertain purity) N-Hethyl-N' -nitro-N-nitrosoguanidine Methyl parathion Methyl propyl ketone, see 2-Pentanone Methyl silicate a-Methyl styrene Hethylthiouracil Metronidazole Mevinphos X X X X X X X X X X X X X X X X X X X X SOURCE* ACCIH h'TP X X TARC X X X X X X X X X X XXX X X X X X X X X XX X X X X X X X X XJ K X X X X XX 4232 1 1 00010 *x x x x HAZARDOUS CHEMICAL CLASSIFICATION GUIDE (FOR USE IN COMPLYING WITH OSHA HA7-ARD COMMUNICATION STA-NDARD 29 CFR 1910.1ZOO) SOURCE11 SUBSTANCE/PROCESS OSHA ACCIH NIP Michler's ketone Mirex Mitomycin C Molybdenum, as Mo Soluble compounds Insoluble compounds XX XX Monocrotaline Monocrotophos Monomethvl aniline X X Monomethyl hydrazine X Horpholine X 5- (Morphoi i nomethyl)-3((5-nitrofurfurylidene ) amino}-2-oxazolidinone Mustard gas, see Nitrogen mustard Nafenopin Naled (Dimethyl-1,2-dibromo-2-dichloroethyl phosphate) X Naphtha (coal ter) Naphthalene alpha-Naphthyl amine X X X B-Naph t hy1amine XX Neon X Nickel Metal XX Soluble compounds, as Ni Nickel carbonyl, as Ni XX XX Nickel subsulfide Nickel sulfide roesting. fume & dust, as Ni Nicotine X X Niridazole Nitrapyrin (2-Chloro-6-(trichloromethyl)pyridine) Nitric acid X X X Nitric oxide XX Nitrilocriacetic acid 5-N itroacenaphthene p-Nitroaniline 5-Nitro-o-anisidine Nitrobenzene 4-Nitrobiphenyl p-Nitrochlorobenzene A-Uitrodiphenyl X X XX X Nitroethane X Nitrofen 1-[(5-Nitrofurfurylidene)ami no 1-2-imidazolidinone N-[4-(5-Nitro-2-furyl)-2-thiezolyllacetamide Nitrogen dioxide X X X X xx I ARC X X 14 00010 A 232 !2 SUSSTAN'CE/PnOCESS Nitrogen trifluoride Nitrogen mustard and Nitrogen mustard N-oxide Nitroglycerin (NG) Nitromethane 1 -- Nitropropene 2-Nitropropane N-Nitrosodi-n-butylamine N-Nitrosodiethanolamine N-Nitrosodiethvlamine N-Nitrosodimethy1amine (dimethyInitrosoamine) p-Nitrosodiphenylamine N-Nitrosodi-n-propylamine N-Ni tros o-h'-e thy lure* N-Nitrosomethylethylamine N-Nitroso-N-methylurea N-Nitroso-N-methylurethane N-Nitrosomethylvinylamine N-Nitrosomorpholine N-Nitrosonornicotine N-NiLrosopiperidine N-Nitrcsopyrrolidine N-Nitrososarcosine Nitrotoluene Nitrotrichlcromethane, see Chloropicrin Nonane Norethisterone Octachloronaphthalene Octane Oestradiol-173 Oestrone Oil mist, mineral Oil orange SS Osmium tetroxide, as Os Oxalic acid Oxygen difluoride Oxymetholone Ozone Panfuran S (Pihydroxymethylfuratrizine) Paraffin wax fume Parecuate, respirable sizes Parathion Particulate polycyclic aromatic hydrocarbons (PFAH), see Coal tar pitch volatiles OSHA X X X X X ACCIH X X X X X NTP 1 ARC X X Xx Xx x xx XX X XX X XX XX XX XX XX XX XX X X X X X 15 00010 A23213 HAZARDOUS CHEMICAL CLASSIFICATION GUIDE (FOR USE IN COMPLYING VITH OSHA HAZARD COMMUNICATION STANDARD. ?9 CfR 1910.1200) SU3STANCE/PROCESSOSHA Pentaborane Pentachloronaphthalene Pentachlorophenol Pentaerythritol Pentane 2-Pentanone (Methyl propyl hetone) Perchloroethylene Perchloromethyl mercaptan Perchloryl fluoride Petroleum distillates (naphtha) Phenacetin Phenazopyradine and its hydrochloride Phenol Phenothiazine Phenoxybenzamine and its hydrochloride N-Phenyl-beta-naphthylamine p-Phenylene diamine Phenyl ether, vapor Phenyl ether-biphenyl mixture, vapor Phenylethylene, see Styrene, monomer Phenyl glycidyl ether (PGE) Phenylhydrazine Phenyl mercaptan Phenylphosphine Phenytoin and its sodium salt Phorate Pho6drin, see Mevinphos Phosgene (carbonyl chloride) Phosphine Phosphorfc acid Phosphorus (yellow) Phosphorus oxychloride Phosphorus pentachloride Phosphorus pentasulfide Phosphorus trichloride Phthalic anhydride m-Phthalodinitrile Picloram Picric acid Pindone Piperazine dihydrochloride 2-Pivalyl-l, 3-indandione, 6ee Pindone (Pival) Plaster of Paris Platinum Metal Soluble salt6. as Pt 16 X X X X X X X X X X X X X X X X X X X X X X . X X SOURCE* ACGIH X X X X X X X X X NTP X X X X X X X I ARC X X X X X X X X X X X X X X X X X X X X X X X X X X X A232 , 00010 HAZARDOUS CHEMICAL CLASS IFICATTON GUIDE (FOR USE IN COMPLYING WITH CSHA HAZARD COMMUNICATION STANDARD. ?9 C~P. 1910.1200) SUBSTANCE/PROCESS OSHA Polybrominated biphenylE (PBB'b) Polychlorinated biphenyls (PCB's) 7 Polytetrafluoroethylene decomposition products Ponceau KX Ponceau 3R Potassium hydroxide Procarbazine end its hydrochloride Progesterone Propane X 1,3-Propane sultone Propargvl alcohol 6-?ropiolectone X Propionic acid Propoxur n-Propyl acetate Propyl alcohol n-Propyl nitrate Propylene Propylene dichloride (1,2 Dichloropropane) X X X X Propylene glycol dinitrate Propylene glycol monomethyl ether Propyleneimine X Propylene oxide (1,2 Epoxypropane) X Propylthiouracil Propyne, see Methyl acetylene Pyrethrum X Pyridine _X Quinone (p-Benzoquinone) X RDX. see Cyclonite Reseroine Resorcinol Rhodium Metal, fume and dusts, as Rh X Soluble salts, as Rh X Ronnel X Rosin core solder pyrolysis products, a6 formaldehyde Rotenone (commercial) X Rouge Rubber solvent (Naphtha) Saccharin, see Sodium saccharin Saf role SOURCE1 ACGIH NTP X X X X X X X X X X X X X X X X X X X X X X X X X X X URC 17 00010 *232JS HAZARDOUS CHEMICAL CLASSIFICATION GUIDE (FOR USE ITT COMPLYING 1'ITH OSHA HAZARD COMMUNICATION STANDARD. 29 CFR 1910.1700) SUB ST A.HCE/PROCESS OSHA Selenium compounds, is St X Selenium hexafluoride, as Se X Selenium Sulfide Sesone (Sodium 2,4-dichloro-phenoxyethyl 6ulfate) Silane, see Silicon tetrahydride Silica, Silicates - See MINERAL'DUSTS, page 22 Silicon Silicon carbide Silicon tetrahydride (Silane) Silver, as Ag Metal Soluble compounds X X Sintered calcium chromate Sintered chromium trioxide Sodium azide Sodium bisulfite Sodium 2, 4-dichloro-phenoxyethyl sulfate, see Sesone Sodium fluoroacetate (1060) X Sodium hydroxide X Sodium metabisulfite Sodium saccharin Soots, tars and mineral oils Starch Stibine Sterigmatocystin X Stoddard solvent Stroptozotocin X Strontium chromate Strychnine Styrene, monomer X X Subtilisins (Proteolytic enzymes as 1007. pure crystalline enzyme) Sucrose Sulfallate Sulfotep Sulfur dioxide X Sulfur hexafluoride Sulfuric acid X _x Sulfur monochloride X Sulfur pentafluoride Sulfur tetrafluoride Sulfuryl fluoride X X Systox, 6ee Demeton SOURCE* ACCIH NTP X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X XX X X X TARC X X 18 00010 SU3S7A),'CE/PROCESS 2. A. 5-T Tantalum TEDP, see Sulfotep Tellurium & compounds, as Te Tellurium hexafluoride, as Te % Temepho6 TEPP lerphenyls Testosterone and its esters 2,3,7,6-Tetrachlorodibenzo-p-dioxin (TCDD) 1,1 ,l,2-Tetrachloro-2, 2-difluoroethane 1,1,2,2-Tetrechloro-l, 2-difluoroethane 1,1,2,2-Tetrachloroethane Tetrachloroethylene. see Perchloroethylene Tetrachloromethane, see Carbon tetrachloride Tetrachloronephthalene Tetraethyl lead, as Pb Tetrahydrofuran Tetramethyl lead, as Pb Tetramethyl succinonitrile Tetranitromethane Tetrasodium pyrophosphate Tetryl <2,A,6-trinitropheny1-methyInitramine) Thallium Soluble compounds, as T1 Thioacetamide A.A'-Thiobis (6-tert. butyl-m-cresol) A, A '-Thiodianiline Thioglycollc acid Thiourea Thiram Tin Metal Oxide & inorganic compounds, except SnO*, as Sn Inorganic compounds, except oxides Organic compounds, as Sn Titanium dioxide, as Ti o-Tolidine Toluene (toluol) Toluene-2, A-diisocyanate (TDI) o-Toluidine o-Toluidine hydrochloride Toxaphene, 6ee Chlorinated camphene Tributyl phosphate Trichloroacetic acid OSHA X X X X X X x X X X X X X X X X X X X X X X X X X SOURCE ACGIH NTP X X X X X X X X X X X I ARC X X X X X X X X X X X X X X X X X X X X X X X XX X X X X X X X 19 00010 HAZARDOUS CHEMICAL CLASSIFICATION' GUIDE (FOR USE IN COHPLYINC WITH OSHA HAZARD COMMUNICATION STANDARD 29 CFR 1910.1200) SUB STANCE/PROCESS______________________________________OSHA 1,2,4-Trichlorobenzene 1.1.1-Trichloroethane, 6ee Methyl chloroform 1.1.2-Trichloroethane X Trichloroethylene Trichlorofluorometha'ne (fluorotrichloromethane) X Trichloromethane, see Chloroform 2,4,6-Trichlorophenol Trichloronephthalene X Trichloronitromethene, see Chloropicrin 2.4.6-Trichlorophenol 1.2.3-Trichloropropane X 1,1,2-Trichloro-1,2,2-trifluoroethane X Tricyclohexyltin hydroxide, see Cyhex&tin Triethylamine X Tr i fluorobromomethane Trifluoromonobromomethane X Trimellitic anyhdride Trimethylamine Trimethyl benzene Trimethyl phosphite 2.4.6-Trinitrophenol, see Picric acid 2.4.6-Trinitrophenyl-methylnitramine, see Tetryl 2.4.6-Trinitrotoluene (TNT) X Triorthocresyl phosphate X Triphenyl amine Triphenyl phosphate X Tris (1-aziridinyl) phosphine sulfate (Thiote'pa) Tris (1-aziridinyl) phosphine sulfide Tris (2,3-dibromopropyl) phosphate Trypan Blue (commercial grade) Tungsten, as W Insoluble compounds > Soluble compounds Turpentine ... Uracil Mustard X Uranium (natural), Soluble X & Insoluble compounds, as U Urethane X * Valeraldehyde Vanadium, as V2 OS. respirable dust k fume Vegetable oil mists X Vinyl acetate Vinyl benzene, see Styrene Vinyl bromide SOURCE* ACGIH NIP_______I ARC X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X 20 00010 *23218 SUBSTANCE/PROCESS OSHA Vinyl chloride (Chloroethylene) Vinyl cyanide, see Acrylonitrile Vinyl cyciohexene dioxide Vinylidene chloride (1,1 Dichloroethylene) Vinyl toluene VH & P Naphtha .. Warfarin Welding fumes Wood dust (certain hard woods as beech &oak) Soft wood ' Xylene (o-, m-, p-isomers)(xylol)(Dimethyl benzene) m-Xylene a, a'-diamine Xylidine (Dimethylaminobenzene) Yttrium Zinc beryllium silicate Zinc chloride fume Zinc chromate, as Cr Zinc oxide Fume Dust Zinc stearate Zirconium compounds, as Zr X X X X X X X X X SOURCE ACGIH KTP X X X X X X X X X X X X X X X X X X URC X X X 21 00010 HAZARDOUS CHEMICAL CLASSIFICATION' GUIDE (FOR USE IN COMPLYING WITH OSKA HAZARD COMMUNICATION STANDARD. ?9 CFR 1910.1200) SUBSTANCE/PROCESS_______ MINERAL DUSTS Silica. SiO? Crystalline Quart* Cristobalite Tridymite Silica, fused Tripoli Amorphous, including natural dietomaceous earth Silicates (17. quartz) Asbestos Graphite Mica Mineral Wool Fiber Perlite Portland Cement Soapstone Talc (non-asbestos) Talc (fibrous) Tremolite (talc, fibrous) Coal DustInert (Nuisance) Dust OSHA SOURCE* ACGIH NTP I ARC XX XX XX XX X X XX XX XX XX XX X X XX XX XX XX X XX XX XX 22 00010 A 2/ o0 22c HAZARDOUS CHEMICAL CI.ASSIFICATION'-GUTDE Sources used in conpling this listing are a6 follows: OSHA: 29 CFR Part 1910, Subpart Z. Toxic and Hazardous Substances, Occu pational Safety end Health Administration ACGIH: Threshold Limit Velues for Chemical Substances end Phvsicei Azents in the Work Environment. 1983-1984 edition, American Conference of Governmental Industrial Hygienists NTP: Annual Report on Carcinogens, third edition, National Toxicology Program, Public Health Service, U. S. Department of Health and Human Services IARC: Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans, 1982, International Agency for Research on Cancer, World Health Organization. The OSHA Hazard Communication Standard, 29 CFR 1910.1200 (d)(3), states: 'The chemical manufacturer, importer or employer (emphasis added) shall* treat the (above) sources as establishing that the chemicals listed in them are hazardous." This listing i6 considered a "baseline" for identification of chemicals designated as a "health hazard," and should not be considered allinclusive. In addition to "health hazards," the OSKA definition of a "hazardous chemical" includes those representing "physical hazards" as well. A "physical hazard" is defined as any substance which is combus tible liquid,** a compressed gas, explosive, flammable, an organic per>xide, an oxidizer, pyrophoric, unstable or water-reactive. Any such substance must also be treated as a "hazardous chemical" for purposes of complying with the standard, regardless of whether it is included in this listing. * Prepared "by: Chemical Section Committee National Safety Council May, 1984 23 00010 A 23221 WORLD HEALTH ORGANIZATION INTERNATIONAL AGENCY FOR RESEARCH ON CANCER IARC MONOGRAPHS ON THE f EVALUATION OF THE CARCINOGENIC RISK OF CHEMICALS TO HUMANS Chemicals, Industrial Processes and Industries Associated with Cancer in Humans IARC Monographs, Volumes 1 to 29 ' SUPPLEMENT 4 Report of u IARC ad hoc Woriing Croup 'which me: in Lyon, 8-12 February 1982 to adrise tie Director, IARC, on chemicals. industrial processes and industries that are carcioogcak for buna ns INTERNATIONAL / GENC^gC^R^ARC -i ON CANCER S=**ZtATT A23222 14 IARC MONOGRAPHS SUPPLEMENT 4 Group 2 The chemical, group of chemicals, industrial process or occupational exposure is probably carcinogenic to humans. This category includes exposures tor which, at one extreme, the evidence ot human carcinogenicity is almost 'sufficient, as well as exposures for which, at the other extreme, it is inadequate. To reflect this range, the category was divided into higher (Group A) and lower (Group B) degrees of evidence. Usually, category 2A was reserved for exposures for which there was at least limited evidence of carcinogenicity to humans. The data from studies in experimental animals played an important role in assigning studies to category 2, and particularly those in Group B; thus, the combination of sufficient evidence in animals and inadequate data in humans usually resulted in a classification of 2B. In some cases, the Working Group considered that the known chemical properties of a compound and the results from short-term tests allowed its transfer from Group 3 to 2B or from Group 2B to 2A. Group 3 The chemical, group of chemicals, industrial process or occupational exposure cannot be classified as to its carcinogenicity to humans. RESULTS AND CONCLUSIONS The assessments of degrees of evidence for carcinogenicity to humans and in experimental animals and for activity in short-term tests, as well as the summary evaluations of carcinogenic risk to humans are given in Table 1. Group 1: The Working Group concluded that the following 7 industrial processes and occupational exposures and 23 chemicals and groups of chemicals are causally associated with cancer in humans*. Industrial processes and occupational exposures: Auramine manufacture Boot and shoe manufacture and repair (certain occupations) Furniture manufacture Isopropyl alcohol manufacture (strong-acid process) Nickel refining Rubber industry (certain occupations) Underground haematite mining (with exposure to radon) Tt*s hst ooes not maude known human carcinogens such as tobacco smoke, bet* quid and alcohofec beverages, smce they have not yet been covered m the Monograons programme Chemicals a: 4-Amino: Analgesic Arsenic z Asbestc: Azathiop Benzene Benzidinr N.N-Bis(i Bis(Ch!or: 1,4-Buta: Certain c Chloram: Chromiur Conjugal Cyclophc Diethyls:: Melphala Methoxs: Mustard 2-Naphtf Soots, ta Treosulp: Vinyl chic Group 2r. T probably carcir Group 2A Acrylonit: Aflatoxin: Benzofai: Beryllium Combiner Diethyl si Dimethyl Manufac: Nickel an Nitrogen Oxymeth Phenacet Procarba: orfrto-Tci 42322.3 * The compound* Procarbame. r * Mmerat ois m; hydrocarbons. tposure is :h. at one exposures egory was /. category /iOence of played an :p B; thus, ins usually operties of >roup 3 to jre cannot ts and in su( ry messes and e causally and alconotc t i RESULTS AND CONCLUSIONS Chemicals and groups of chemicals: 4-AminoDiphenyl Analgesic mixtures containing phenacetin* Arsenic and arsenic compounds* Asbestos Azathioprine Benzene Benzidine N.N-Bis(2-chloroethyl)-2-naphthylamine (Chlornaphazine) Bis(chloromethyl)ether and technical-grade chtoromethyl methyl ether 1,4-Butanediol dimethanesulphonate (Myleran) Certain combined chemotherapy for lymphomas* (including MOPP0) Chlorambucil Chromium and certain chromium compounds* Conjugated oestrogens* Cyclophosphamide Diethyls titboes trot Melphalan Methoxsalen with ultra-violet A therapy (PUVA) Mustard gas 2-Naphthylamine Soots, tars and oils** Treosulphan Vinyl chloride 15 Group 2: The following 61 chemicals, groups of chemicals or industrial processes are probably carcinogenic to humans Group 2A Acrylonitrile Aflatoxins Benzojajpyrene Beryllium and beryllium compounds* Combined oral contraceptives* Diethyl sulphate Dimethyl sulphate Manufacture of magenta* Nickel and certain nickel compounds Nitrogen mustard Oxymetholone Phenacetin Procarbazine orfho-Toluidine * The compounds) responsible lor the carcinogenic effect in humans cannot oe specified. * Procarbazine, nitrogen mustard, mncristme and prednisone * Mineral oils may vary in compositen. particularly m relation to their content of carcinogenic poiycycw aromatic hydrocarbons. A23224 16 IARC MONOGRAPHS SUPPLEMENT 4 Croup 2B Actinomycin D Adriamycin Amitrole Auramine (technical grade) Benzotrichloride Bischloroethyl nitrosourea (BCNU) Cadmium and cadmium compounds Carbon tetrachloride Chloramphenicol 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) Chloroform Chlorophenols (occupational exposure to)' Cisplatin Dacarbazine DDT 3.3'-Dichlorobenzidine Dianoestrol 3.3-Dimethoxybenzidine (orfhoDianisidine) Dimethylcarbamoyl chloride 1.4-Dioxane Direct Black 38 (technical grade) Direct Blue 6 (technical grade) Direct Brown 95 (technical grade) Epichlorohydrin Ethinyloestradiol Ethylene dibromide Ethylene oxide Ethylene thiourea Formaldehyde (gas) Hydrazine Mestranol Metronidazole Norethisterone Oestradiol-17p Oestrone Phenazopyridine Phenytoin Phenoxyacetic acid herbicides (occupational exposure tb)* Polychlorinated biphenyls Progesterone Propylthiouracil Sequential oral contraceptives* Tetrachlorodibenzo-para-dioxin (TCDD) 2.4.6-Trichlorophenol * Tris(aziridinyl)-para-benzoquinone (Triaziquone) Tris(l-aziridinyl)phosphine sulphide (Thiotepa) Uracil mustard Croup 3: The remaining 64 chemicals, groups ol chemicals, industrial processes and occupational exposures could not be classified as to their carcinogenicity to humans. * The compound)*) lesoonsow lor the prooatte carcinogenic etfaci m humans cannot 0* spedhad A2322S Table t process? animals Chernies or indus: Acrylonr Actinorrv Adriamy Aflatoxir Aidrin 4-Aminc Amitrole Anaesth Analgesi phena Phene Aniline Arsenic compc Asbestc Auramir. Manulac Azathio: Benzene Benzidir Benzidir Direct gra: Direct gra: Direct gra: Berylliur comp) N.N-Biii napht (Chlor Bischlor (BCNt Bis(chlc techm chiorc In lAf T Tn Coverages rocesses and 3ns. RESULTS AND CONCLUSIONS 17 Table 1. Summary evaluations ol carcinogenic risk to humans from chemicals, industrial processes and industries* based on evidence for carcinogenicity to humans and to animals and for activity in short-term testsf Chemical, process or industry Evidence for carci nogenicity in humans Evidence for carci nogenicity in animals Evidence for activity in short-term tests Summary evaluation of carcino genic risk to humans Acrylonitrile Actinomycin 0 Adriamycin Aflatoxins Aldrin 4-Aminobiphenyl Amitrole Anaesthetics, volatile Analgesic mixtures containing phenacetin Phenacetin Aniline Arsenic and certain arsenic ... .compounds Asbestos 'AuFamine (technical grade) Manufacture of auramine Azathioprine Benzene Benzidine Benzidine-based dyes Direct Black 38 (technical grade) Direct Blue 6 (technical grade) Direct Brown 95 (technical grade) - Beryllium and beryllium compounds /V.N-Bis(2-chloroethyl)-2naphthylamine (Chlornaphazine) Bischloroethyl nitrosourea (BCNU) Bis(chloromethyl)ether and technical-grade chloromethylmethyl ether limited inadequate inadequate limited inadequate sufficient inadequate inadequate sufficient limited sufficient sufficient limited sufficient sufficient inadequate sufficient limited inadequate limited sufficient limited sufficient sufficient limited sufficient sufficient sufficient sufficient inadequate sufficient limited -. limited limited sufficient sufficient sufficient sufficient sufficient inadequate sufficient inadequate inadequate no data limited inadequate limited inadequate sufficient . sufficient limited sufficient 2A 2B 2B 2A 3 1 2B 3 1 2A 3 1 1 2B 1 1 1 1 inadequate inadequate inadequate limited sufficient sufficient limited sufficient inadequate no data no data inadequate 2B 2B 2B 2A sufficient inadequate limited sufficient limited sufficient 1 SB sufficient sufficient limited 1 ---------------- In IARC Monographs 1-29. lor which data in humans were avallibls t This table floes not include known human carcinogens such as lobacco smoke, betel quid and eIcorto! beverages, since they have not yet been considered in the MAC Monographs. A23226 ! 18 IARC MONOGRAPHS SUPPLEMENT 4 Chemical, process or industry Bleomycins 1.4-ButanediOl dimethanesulphonate (Myleran) Cadmium and cadmium compounds Carbon tetrachloride Certain combined chemotherapy for lymphomas (including MOPP) Chlorambucil Chloramphenicol Chlordane/Heptachlor 1 -(2-Chloroethyl)-3-cyclohexyl1 -nitrosourea (CCNU) Chlorinated toluenes (production of): Benzyl chloride Benzoyl chloride Benzal chloride Benzotrichloride Chloroform Chforophenols (occupational exposure to) Chloroprene Chromium and certain chromium compounds Cisplatin Ctofibrate Clomiphene Cydamates Cyclophosphamide 2,4-0 and esters (See also Phenoxyacetic acid herbicides, occupational exposure to) Dacarbazine Dapsone DDT orrho-Dichiorobenzene and para-Dichiorobenzene Evidence for carci nogenicity in humans Evidence lor carci nogenicity in animals Evidence for activity in shorl-term tests Summary evaluation of carcino genic risk to humans inadequate inadequate sufficient 3 sufficient limited inadequate limited sufficient sufficient sufficient inadequate inadequate 1 2B 2B sufficient sufficient limited inadequate inadequate - sufficient inadequate limited sufficient inadequate sufficient inadequate inadequate sufficient 1 1 2B 3 2B inadequate inadequate inadequate inadequate inadequate limited inadequate sufficient inadequate inadequate inadequate inadequate sufficient limited inadequate limited sufficient sufficient inadequate sufficient limited limited inadequate limited sufficient sufficient inadequate limited limited inadequate - sufficient sufficient (Cr VI) inadequate (Cr III) sufficient inadequate no data inadequate sufficient 3 3 3 2B 2B 2B 3 1 2B 3 3 3 1 inadequate inadequate inadequate inadequate inadequate inadequate sufficient limited sufficient inadequate inadequate limited inadequate inadequate inadequate 3 2B 3 2B 3 ChemicE or indus; 3.3- Oicr. Oichloror Oieldrin Diethyl s3.3'-Dime' Oianisic Dimethyic Dimethyl 1.4- Dioxa Epichlorc* Ethylene Ethylene : Ethylene* 5-Fluorour Formatter HexachlcrHydralazrr Hydrazine Industries Boot arr and re oocup; Carpentexpos. Fumiturs Leather Leather Lumber Pulp ar.c (certair Rubber occupz Iron dextrar Isonicotimc Lead and te Manufactur alcohol (s Isopropyl Manulactur= Magenta Melphalan 6-Mercaptcc A23227 Summary evaluation of carcino genic risk to humans 3 1 23 2B :B 3 3 1( RESULTS AND CONCLUSIONS 19 Chemical, process or industry Evidence for carci nogenicity in humans Evidence for carci nogenicity in animals Evidence for activity in short-term tests Summary evaluation of carcino genic risk to humans 3.3'-Dichtorobenzidine Oichtoromethane Oietdrin Oiethyl sulphate 3.3-Dimethoxybenzidine {ortho- Oianisidine) Dimethylcarbamoyl chloride Dimethyl sulphate 1,4-Dioxane Epichlorohydrin Ethylene didromide Ethylene oxide Ethylene thiourea 5-Fluorouracil Formaldehyde (gas) Hexachlorocyclohexane Hydralazine Hydrazine Industries Boot and shoe manufacture and repair (certain occupations) Carpentry and joinery (certain exposures) Furniture manufacture Leather goods manufacture Leather tanning Lumber and sawmill industry Pulp and paper manufacture (certain exposures) Rubber industry (certain occupations) Iron dextran complex Isonicotinic acid hydrazide Lead and lead compounds Manufacture of isopropyl alcohol (strong-acid process) Isopropyl oils Manufacture of magenta Magenta (technical grade) Melphaian 8-Mercaptopurine inadequate inadequate inadequate limited inadequate inadequate inadequate inadequate inadequate inadequate inadequate inadequate inadequate inadequate inadequate inadequate inadequate sufficient inadequate limited sufficient sufficient sufficient sufficient sufficient sufficient sufficient limited sufficient inadequate sufficient limited limited sufficient sufficient limited inadequate sufficient limited sufficient sufficient inadequate sufficient sufficient sufficient limited limited sufficient inadequate sufficient sufficient 2B 3 3 2A 2B 2B 2A 2B 2B 2B 2B 2B 3 2B 3 3 2B sufficient inadequate sufficient inadequate inadequate inadequate inadequate sufficient inadequate inadequate inadequate sufficient inadequate limited inadequate sufficient inadequate - -- --- -- - sufficient limited sufficient (for some salts) inadequate limited inadequate - inadequate - inadequate sufficient inadequate - no date - inadequate sufficient sufficient 1 3 1 3 3 3 3 1 3 3 3 1 3 2A 3 1 3 A23228 20 IARC MONOGRAPHS SUPPLEMENT 4 Chemical, process or industry Methotrexate Methoxsalen with ultraviolet A therapy (PUVA) Metronidazole Mustard gas 1-Naphthy!amine 2-Naphthylamine Nickel refining Nickel and certain nickel compounds Nitrogen mustard (See also Certain combined chemotherapy for lymphomas) Oestrogens and progestins Combined oral contraceptives Sequential oral contraceptives Other oestrogen-progestin combinations Conjugated oestrogens Oestrogens Oienoestrol Diethyistilboestro! Ethinyloestradiol Mestranol Oestradiol-173 Oestrone Prooestins: Chlormadinone acetate Dimethisterone Ethynodiol diacetate 173-Hydroxyprogesterone caproate Lynoestrenol Medroxyprogesterone acetate Megestrol acetate Norethisierone Norethynodrel Norgestrel Progesterone Su-fC*n: lor kvcf Menomas Evidence for cardnogenicity in humans inadequate sufficient inadequate sufficient inadequate sufficient sufficient limited Evidence for cardnogenicity in animals inadequate sufficient sufficient limited inadequate sufficient - suffident Evidence for activity in short-term tests suffident sufficient limited sufficient suffident sufficient - inadequate inadequate limited* limited inadequate suffident suffident - - inadequate suffident inadequate - - inadequate limited sufficient inadequate inadequate inadequate inadequate inadequate sufficient suffident sufficient sufficient sufficient inadequate inadequate inadequate inadequate inadequate inadequate inadequate inadequate inadequate inadequate inadequate inadequate inadequate limited inadequate limited inadequate inadequate limited limited inadequate inadequate inadequate no data inadequate inadequate inadequate inadequate inadequate inadequate inadequate sufficient limited inadequate sufficient inadequate inadequate no data inadequate Summary evaluation of carcinogenic risk to humans 3 1 2B 1 3 1 1 2A 2A 2A 2B 3 1 2B 1 2B 2B 2B 2B 3 3 3 3 3 3 3 2B 3 3 2B Chemica: or indus:.* OxymetrPentach.: Chlorcr expose Phenazc: Phenelzir Phenobar Phenoxya (occupa Phenylbu: A/-PhenylPhenytoir Polychlorr Predniscr. combine lympher Procarbaa. combine lympher Propylthic. Reserpine Saccharin Soots, tarc Benzc(s Spironolac Styrene Styrene Sulfafurarr Sulfameth: 2.4.5-T an: Phenox-. herbidce exposur? Tetrachlor: (TCOO) Tetrachlor: orrrto-Tolu. Treosulpha Trichloroe" 2.4.5-Tric!*r Chloropr exposure 2.4.6-Tricnv Chloropr A23223 <t m jmmary saluation ' carcinomic risk humans RESULTS AND CONCLUSIONS 21 Chemical, process or industry Oxymetholone Pentachlorophenol (See also Chlorophenols, occupational exposure to) Phenazopyridine Phenelzine Phenobarbital Phenoxyacetic acid herbicides (occupational exposure to) Phenylbutazone W-Phenyl-2-naphthylamine Phenytoin Polychlorinated biphenyls Prednisone (See also Certain combined cl lemotherapy for lymphomas) Procarbazine (See also Certain combined chemotherapy for lymphomas) Propylthiouracil Reserpine Saccharin Soots, tars and oils 8enzo[a]pyrene Spironolactone Styrene Styrene oxide Sulfafurazole Sulfamethoxazole 2.4.5-T and esters (See also Phenoxyacetic acid herbicides, occupational exposure to) Tetrachiorodibenzo-para-dioxin (TCOO) Tetrachloroethylene ortho-Toluidine Treosulphan Trichioroethylene 2.4.5-Trichiorophenoi (See also Chlorophenols. occupational exposure to) 2.4.6-Trichlorophenol (See also Chlorophenols. occupational exposure to) Evidence for carci nogenicity in humans limited Evidence for carci nogenicity in animals no data Evidence for activity in short-term tests no data Summary evaluation of carcino genic risk to humans 2A inadequate inadequate inadequate inadequate limited inadequate inadequate limited inadequate inadequate sufficient limited limited . no data inadequate limited sufficient inadequate no data inadequate inadequate - inadequate inadequate inadequate inadequate 3 2B 3 3 2B 3 3 2B 2B inadequate inadequate inadequate 3 inadequate inadequate inadequate inadequate sufficient inadequate inadequate inadecuate inadecuate inadequate inadequate sufficient sufficient limited limited sufficient sufficient limited limited limited inadequate limited sufficient no data inadequate inadequate . sufficient no data sufficient sufficient inadequate inadequate 2A 2B 3 3 1 2A 3 3 3 3 3 inadequate inadequate inadequate inadecuate sufficient inadequate inadequate sufficient limited sufficient no data limited inadequate inadequate inadequate sufficient inadequate inadequate 3 2B 3 2A 1 3 inadequate inadequate no data 3 inadequate sufficient no data 2B m mmmm A2323C 22 IARC MONOGRAPHS SUPPLEMENT 4 Chemical, process or industry Tris(az:ridinyl)-p3ra-benzoquone (Triaziquone) Tris(1 -aziridinyl)phosphine sulphide (Thiotepa) Underground haematite mining (with exposure to radon) Haematite Uracil mustard Vinblastine Vincristine (See also Certain combined chemotherapy (or lymphomas) Vinyl chloride Vinylidene chloride -Evidence (or card- nogenidty in humans Evidence (or cardnogenicity in animals Evidence (or activity in short-term tests Summary evaluation o( carcinogenic risk to humans inadequate inadequate su(f>cient inadequate inadequate inadequate limited sufficient inadequate sufficient inadequate suffident sufficient . inadequate suffident inadequate 2B 2B 1 3 2B 3 inadequate sufficient inadequate inadequate sufficient limited inadequate sufficient suffident 3 | 3 A23231 ' IARC of - MARC to * IARC to in IARC ass Me * Berenc F.F 32: Foulds. 1 Farber. CaS Weinsi pre * Slaga. Cc. Miller. 10: " Brooke hyc PO'. 76- * Lawlev Cc. PC- McCar Sa` Sc. 14 Weisb: c.: Pc 1983 N'TP Carcinogen List TABLE 43 CHEMICALS, SUBSTANCES AND MANUFACTURING PROCESSES INCLUDED IN THE THIRD ANNUAL REPORT ON CARCINOGENS 1. 2-Acetylaminofluorene 2. Acrylonitrile 3. Aflatoxins 4. 2-Aminoanthraquinone 5. 4-Aminobiphenyl 6. l-Amino-2-Methylanthraquinone 7. Amitrole 8. o-Anisidine Hydrochloride 9. Aramite 10. Arsenic and certain arsenic compounds 21. Asbestos 12. Auramine, Manufacture of 13. Benz(a)anthracene 14. Benzene 15. Benzidine 16. Benzo(b)fluoranthene 17. Benzo(a)pyrene 18. Beryllium and Certain Beryllium Compounds ( 19. N,N-bis(2-chloroethy1)-2-naphthylamine 20. Bis(chloromethyl)ether and technical grade chlorometbylmethyl ether 21. Cadmium and Certain Cadmium Compounds 22. Carbon Tetrachloride 23. Chlorambucil 24. Chloroform 25. Chromium and certain chromium compounds 26. Coke oven emissions 27. p-Cresidine 28. Cupferron 29. Cycasin 30. Cyclophosphamide 31. 2,4-Diaminoanisole Sulfate 32. 2,4-Diaminotoluene 33. Dibenz{a,h)acridine 34. Dibenz(a,jlacridine 35. Dibenz(a,h)anthracene 36. 7H-Dibenzo(c,g)carbazole 37. Dibenzo(a,h)pyrene 38. Dibenzo(a,1)pyrene 39. l,2-Dibromo-3-chloropropane 40. 1,2-Dibromoethane 41. Dichlorobenzidine 42. 1,2-Dichloroethane 43. Diepoxybutane 44. Di(2-ethyl hexyl)phthalate A2323? 278 1983 NTP Carcinogen List TA8LE 43 (Continued) 45. Oiethylstilboestrol 46. 3,3'-Dimethoxybenzidine 47. 3,3'-Dimethylbenzidine 48. 4-Dimethylaminoazobenzene 49. Dimethylcarbamoyl Chloride 50. Dimethyl Sulfate 51. 1,4-Dioxane 52. Direct Black 38 53. Direct Blue 6 54. Ethylene Thiourea 55. Formaldehyde 56. Haematite underground mining 57. Hexachlorobenzene 58. Hydrazine and Hydrazine Sulfate 59. Hydrazobenzene 60. Indenod,2,3-cd)pyrene 61. Iron Dextran 62. Isopropyl Alcohol 63. Kepone 64. Lead Acetate and Lead Phosphate 65. Lindane and Other Hexachlorocyclohexane Isomers 66. Melphalan 67. 4,4'-Methylene bis(2-chloroaniline) 68. 4,4'-Methylene bis(N,N-dimethyl) benzenamine 69. Michler's Ketone 70. Mirex 71. Mustard gas 72. 2-Naphthyl amine 73. Nickel refining 74. Nitrilotriacetic acid 75. Nitrofen 76. 5-Nitro-o-anisidine 77. N-Nitrosodi-n-butylamine 78. N-Nitrosodiethanolamine 79. N-Nitrosodiethylamine 80. N-Nitrosodimethylamine 81. p-Nitrosodiphenylamine 82. N-Nitrosodi-n-propyl amine 83. N-Nitroso-N-ethyl urea 84. N-Nitroso-N-methylurea 85. N-Nitrosomethylvinylamine 86. N-Nitrosomorpholine 87. N-Nitrosonornicotine 88. N-Nitrosopiperidine 89. N-Nitrosopyrrolidine 90. N-Nitrososarcosine 91. Oxymetholone , 92. Phenacetin 279 A23233 ii inn in ii m mm-Tin i n nnnniuni I 1983 NTP Carcinogen Lise TABLE 43 (Continued) 93. Phenazopyridine hydrochloride 94. Phenytoin 95. Polybrominated Biphenyls 96. Polychlorinated 8iphenyls 97. Procarbazine and Procarbazine Hydrochloride 98. B-Propiolactone 99. Reserpine 100. Saccharin 101. Safrole 102. Selenium Sulfide 103. Soots, tars and mineral oils 104. Streptozotocin 105. Sulfallate 106. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TC0D) 107. Thioacetamide 108. Thiourea 109. Thorium dioxide 110. o-Toluidine Hydrochloride 111. Toxaphene 112. 2,4,6-Trichlorophenol 113. Tris(l-aziridinyl)phosphine sulfide 114. Tris(2,3-dibromopropyl)phosphate 115. Urethane 116. Vinyl chloride A 2 3 2 3 '* 280 TCXIC SUBSTANCES S-191 31:8651 [Edltor'i Bote: The Occupational Safety and requires distributors to transmit the Health Administration'] cotton dust standard required information to employers in was vacated and remanded to OSHA by the U.S. Court of Appeals for the Fifth Circuit November 14, 1980, for further consideration of Issue of significant risk of material health Impairment that may be remedied by a SIC Codes 20-39. (2) This section applies to any chemical which is known to be present in the workplace in such a manner that reasonably necessary and appropriate stan employees may be exposed under dard.) normal conditions of use or in a $ 1910.1046 Exposure to cotloa dust to foreseeable emergency. (3) This section applies to.laboralories rollon gins. only as follows: [Section 1910.1046 deleted by 46 FR 32021, (i) Employers shall ensure that labels June 19. 1961] on incoming containers of hazardous } 1910.1200 Hazard communication. chemicals are not removed or defaced; (ii) Employers shall maintain any (See. 1910.1200 added by 48 FR 53280, material safety data sheets that are November 25, 1983) (a) Purpose. (1) The purpose of this section is to ensure that the hazards of all chemicals produced or imported by chemical manufacturers or importers are evaluated, and that information concerning their hazards is transmitted to affected employers ar.demployees withinlhe manufacturing sector. This transmittal of information is to be accomplished by means of comprehensive hazard communication programs, which arc to include container labeling and other forms of warning, material safety data sheets and employee training. (2) This occupational safety and health standard is intended to address comprehensively the issue of evaluating and communicating chemical hazards lo employees in the manufacturing sector, and to preempt any st3te law pertaining to this subject. Any state which desires lo assume responsibility in this area may only do so under the provisions of { 13 of the Occupational Safety and Health Act (29 U.S.C. 651 et. seq.) which deals with state jurisdiction and state plans. (b) Scope and application. (1) This section requires chemical manufacturers or importers to sssess the hazards of chemicals which they produce or import, received with incoming shipments of hazardous chemicals, and ensure that they are readily accessible to laboratory employees; end, (iii) Employers shall ensure that laboratory employees are apprised of the hazards of the chemicals in their workplaces in accordance with paragraph (h) of this section. (4) This section docs not require labeling of the following chemicals: (i) Any pesticide as such term is defined in the Federal Insecticide. Fungicide, and Rudenticide Act'(7 U.S.C. 136 et seq.). when subject to the labeling requirements of that Act and labeling regulations issued under that Act by the Environmental Protection Agency: (ii) Any food, food additive, color additive, drug, or cosmetic, including materials intended for use as ingredients in such products (e.g.. flavors and fragrances), as such terms are defined in the Federal Food. Drug, and Cosmetic Act (21 U.S.C. 301 el seq.) and regulations issued under that Act, when they are subject to the labeling requirements of that Act and labeling regulations issued under that Act by the Food and Drug Administration: (iii) Any distilled spirits (beverage alcohols), wine, or malt beverage intended for nonindustrial use. as such and all employers in SIC Codes 20 terms are defined in the Federal Alcohol through 39 (Division D, Standard Administration Act (27 U.S.C. 201 et Industrial Classification Manual) to seq.) and regulations issued under that provide information to their employees Act, when subject to the labeling about the hazardous chemicals to which requirements of that Act and labeling they are .exposed, by means of a hazard regulations issued under that Act by the communication program, labels and Bureau of Alcohol. Tobacco, and other forms of warning, material safety Firearms: and, data sheets, and information and (iv) Any consumer product or training. In addition, this section hazardous substance as those terms are defined in the Consumer Product Safety Act (15 U.S.C. 2051 et seq.) and Federal Hazardous Substances Act (IS U.S.C 1261 et seq.) respectively, when subject to a consumer product safety standurd or labeling requirement of those Acts, or regulations issued under those Acts by the Consumer Product Safely Commission. (5) This section docs not apply lo: (i) Any hazardous waste as such term is denned by the Solid Waste Disposal Act. as amended by the Resource Conservation and Recovery Act of 1976. as amended (42 U.S.C. 6901 et seq.), when subject lo regulations issued under that Act by the Environmental Protection Agency: (ii) Tobacco or tobacco products; (iii) Wood or wood products: (iv) Articles: and. (v) Foods, drugs, or cosmetics intended for personal consumption by employees while in the workplace. (c) Definitions. "Article" means a manufactured item: (i) Which is formed to a specific shape or design during manufacture; (ii) which has end use function(s) dependent in whole or in part upon its shape or design during end use; and (iii) which does not release, or otherwise result in exposure to. a hazardous chemical under normal conditions of use. "Assistant Secretary" means the Assistant Secretary of Labor for Occupational Safety end Health. U.S. Department of Labor, or designee. "Chemical" means any element, chemical compound or mixture of elements and/or compounds. "Chemical manufacturer" means an employer in SIC Codes 20 through 39 with a workplace where chemical(s) are produced for use or distribution. "Chemical name" means the scientific designation of a chemical in accordance with the nomenclature system developed by the International Union of Pure and Applied Chemistry (IUPAC) or the Chemical Abstracts Service (CAS) rules of nomenclature, or a name which will clearly identify the chemical for the purpose of conducting a hazard evaluation. "Combustible liquid" means any liquid having a flashpoint at or above 100'F (37.8'C). but below 200*F (93J*C). 12-15-0 (Sec. 1910.1200(c)] * Published by THE BUREAU OF NATIONAL AFFAIRS INC.. Washington. DC. 20037 A2323S 31:8652 REFERENCE FILE except any mixture having components security personnel or non-resident shall be considered to be a flammable with flashpoints of 200`F (93.3`C). or management are generally not included, solid if. when tested by the method higher, the total volume of which make unless their job performance routinely described in 16 CFR 1500.44. it ignites up 99 percent or more of the total involves potential exposure to and burns with a self-sustained flame at volume of the mixture. hazardous chemicals. a rate greater than one-tenth of an inch "Common name" means any "Employer" means a person engaged per second along its major axis. designation or identification such as in a business within SIC Codes 20 "Flashpoint" means the minimum code name, code number, trade name, through 39 where chemicals are cither temperature at which a liquid gives off a brand name or generic name used to used, or arc produced for use or vapor in sufficient concentration to identify a chemical other than by its distribution. ignite when tested as follows: chemical name. "Explosive" means a chemical that (i) Tagliabue Closed Tester (See "Compressed gas" means: causes a sudden, almost instantaneous American National Standard Method of (i) A gas or mixture of gases having, in release of pressure, gas. and heat when Test for Flash Point by Tag Closed a container, an absolute pressure subjected to sudden shock, pressure, or Tester. Zll,24-1979(ASTM D 56-79)) for exceeding 40 psi at 70'F (21.1'CJ; or high temperature. liquids with a viscosity of less than 45 (ii) A gas or mixture of gases having, in a container, an absolute pressure exceeding 104 psi at 130*F (S4.4*C) regardless of the pressure at 70`F (2l.l'C): or (iii) A liquid having a vapor pressure exceeding 40 psi at 100`F (37.8`C) as determined by ASTM D-323-72. "Container" means any bag. barrel, bottle, box. can. cylinder, drum, reaction vessel, storage tank, or the like that containes a hazardous chemical. For purposes of this section, pipes or piping systems are not considered to be containers. "Designated representative" means any individual or organization to whom an employee gives written authorization to exercise such employee's rights under this section. A recognized or certified collective bargaining agent shall be "Exposure" or "exposed" means that an employee is subjected to a hazardous chemical in the course of employment through any route of entry (inhalation, ingestion, skin contact or absorption, etc.), and includes potential (e.g., accidental or possible) exposure. "Flammable" means a chemical that falls into one of the following categories: (i) "Aerosol, flammable" means an aerosol thaL when tested by the method described in 16 CFR 1500.45, yields a flame projection exceeding 18 inches at full valve opening, or a flashback (a flame extending back to the valve) at any degree of valve opening: (ii) "Cas. flammable" means: (A) A gas that, at ambient temperature and pressure, forms a flammable mixture with air at a concentration of thirteen (13) percent by Saybolt Universal Seconds (SUS) at 100`F (37.8`C). that do not contain suspended solids and do not have a tendency to form o surface film under test: or (ii) Pensky-Marlens Closed Tester (see American National Standard Method of Test for Flash Point by Pensky-Marlens Closed Tester. Zll.7-1979 (ASTM D 9379)) for liquids with a viscosity equal to or greater than 45 SUS a 100'F (37.8`C). or that contain suspended solids, or that have a tendency to form a surface film under test; or (iii) Setaflash Closed Tester (see American National Standard Method of Test for Flash Point by Setaflash Closed Tester (ASTM D 3276-78)). Organic peroxides, which undergo autoaccelerating thermal decomposition, treated automatically as a designated volume or less: or are excluded from any of the flashpoint representative without regard to written (B) A gas that, at ambient temperature determination methods specified above. employee authorization. and pressure, forms a range of "Foreseeable emergency" means any "Director" means the Director. flammable mixtures with air wider than potential occurrence such as. but not National Institute for Occupational twelve (12) percent by volume, limited to, equipment failure, rupture of Safety and Health, U.S. Department of regardless of the lower limit; containers, or failure of control Health and Human Services, or (iii) "Liquid, flammable" means any equipment which could result in an designee. liquid having a flashpoint below 100*F uncontrolled release of a hazardous "Distributor" means a business, other (37.8*C). except any mixture having chemical into the workplace. than a chemical manufacturer or components with flashpoints of 100*F "Hazard warning" means any words, importer, which supplies hazardous (37.8`C) or higher, the total of which pictures, symbols, or combination chemicals to other distributors or to make up 99 percent or more of the total thereof appearing on a label or other manufacturing purchasers. volume of the mixture. appropriate form of warning which "Employee" means a worker (iv) "Solid, flammable" means a solid, convey the hazards of the chemical(s) in employed by an employer in a other than a blasting agent or explosive the container^). workplace in SIC Codes 20 through 39 as defined in { 1910.109(a). that is liable "Hazardous chemical" means any who may be exposed to hazardous to cause fire through friction, absorption chemical which is a physical hazard or a chemicals under normal operating of moisture, spontaneous chemical health hazard. conditions or foreseeable emergencies, change, or retained heat from "Health hazard" means a chemical for including, but not limited to production manufacturing or processing, or which which there is statistically significant workers, line supervisors, and repair or can be ignited readily and when ignited evidence based on at least one study maintenance personnel. Office workers, bums so vigorously and persistently as conducted in accordance with grounds maintenance personnel. to create a serious hazard. A chemical established scientific principles that ( Occupational Safety 4 Health Reporter [Sec. 1910.1200(c)) 26 A2323P TOXIC SUBSTANCES S-191 31:8653 acute or chronic health effects may O-struciure and which may be chemicals are produced or used, end occur in exposed employees. The term considered to be n structural derivative where employees arc present. "health hazard" includes chemicals of hydrogen peroxide where one or both "Workplace" means an establishment which arc carcinogens, toxic or highly of the hydrogen atoms has been at one geographical location containing toxic agents, reproductive toxins, replaced by an organic radical. one or more work areas. irritants, corrosives, sensitizers, "Oxidizer" means a chemical other (d) Hazard determination. (1) hepatotoxins. nephroloxins. than a blasting agent or explosive as Chemical manufacturers and importers neurotoxins, agents which act on the defined in $ 1910.109(a). (hat initiates or shall evaluate chemicals produced in hematopoietic system, and agents which promotes combustion in other materials, their workplaces or imported by them to damage the lungs, skin. eyes, or mucous thereby causing fire cither of itself or determine if they are hazardous. membranes. Appendix A provides through the release of oxygen or other Employers are not required to evaluate further definitions and explanations of gases. chemicals unless they choose not to rely the scope of health hazards covered by "Physical hazard" means a chemical on the evaluation performed by the this section, and Appendix B describes for which there is scientifically valid chemical manufacturer or importer for the criteria to be used to determine evidence that it is a combustible liquid, the chemical to satisfy this requirement. whether or not a chemical is to be a compressed gas, explosive, flammable, (2) Chemical manufacturers, importers considered hazardous for purposes of an organic peroxide, an oxidizer, or employers evaluating chemicals shall thi&tandard. pyrophoric, unstable (reactive) or water- identify and consider the available "Identity" means any chemical or reactive. scientific evidence concerning such common name which is indicated on the "Produce" means to manufacture, hazards. For health hazards, evidence material safety data sheet (MSDS) for the chemical. The identity used shall permit cross-references to be made among the required list of hazardous process, formulate, or repackage. "Pyrophoric" means a chemical that will ignite spontaneously in air at a temperature of 130' F (54.4* C) or below. which is statistically significant and which is based on at least one positive study conducted in accordance with established scientific principles is chemicals, the label and the MSDS. "Immediate use" means that the hazardous chemical will be under the control of and used only by the person who transfers it from a labeled container and only within the work shift in which it is transferred. "Importer" means the first business with employees within the Customs Territory of the United States which receives hazardous chemicals produced in other countries for the purpose of supplying them to distributors or manufacturing purchasers within the United States. "Label" means any written, printed, or graphic material displayed on or affixed to containers or hazardous chemicals. "Manufacturing purchaser" means an employer with a workplace classified in SIC Codes 20 through 39 who purchases a hazardous chemical for use within that workplace. "Material safety data sheet (MSDS)" means written or printed material concerning a hazardous chemical which is prepared in accordance with "Responsible party" means someone who can provide additional information on the hazardous chemical and appropriate emergency procedures, if necessary. "Specific chemical identity" means the chemical name. Chemical Abstracts Service (CAS) Registry Number, or any other information that reveals the precise chemical designation of the substance. 'Trade secret" means any confidential formula, pattern, process, device, information or compilation of information (including chemical name or other unique chemical identifier) that is used in an employer's business, and that gives the employer an opportunity to obtain an advantage over competitors who do not know or use it. "Unstable (reactive)" means a chemical which in the pure state, or as produced or transported, will vigorously polymerize, decompose, condense, or will become self-reactive under conditions of shocks pressure or temperature. "Use" means to package, handle, considered to be sufficient to establish a hazardous effect if the results of the study meet the definitions of health hazards in this section. Appendix A shall be consulted for the scope of health hazards covered, and Appendix B shall be consulted for the criteria to be followed with respect to the completeness of the evaluation, and the data to be reported. (3) The chemical manufacturer, importer or employer evaluating chemicals shall treat the following sources as establishing that the chemicals listed in them are hazardous: (i) 29 CFR Part 1910, Subpart Z. Toxic and Hazardous Substances, Occupational Safety and Health Administration (OSHA); or, (ii) Threshold Limit Values for ChemicalSubstances and Physical Agents in the Work Environment. American Conference of Governmental Industrial Hygienists (ACGIH) (latest edition). The chemical manufacturer, importer, or employer is still responsible for paragraph (g) of this section. react, or transfer. evaluating the hazards associated with "Mixture" means any combination of "Water-reactive" means a chemical the chemicals in these source lists in two or more chemicals if the that reacts with water to release a gas accordance with the requirements of the combination is not. in whole or in part, that is either flammable or presents a standard. the result of a chemical reaction. health hazard. (4) Chemical manufacturers, importers "Organic peroxide" means an organic "Work area" means a room or defined and employers evaluating chemicals compound that contains the bivalent -O- space in a workplace where hazardous shalftreat the following sources as 12-15-83 fSec. 1910.1200(d)(4)) Published by THE BUREAU OF NATIONAL AFFAIRS INC.. Washington. O.C. 20037 27 (123237 31:8654 REFERENCE RILE establishing that a chemical is a j Threshold Limit Value, or could present carcinogen or potential carcinogen for / a health hazard to employees in those hazard communication purposes: J concentrations, the mixture shall be (i) National Toxicology Program | assumed to present the same hazard. (NTP), Annual Report on Carcinogens ' (6) Chemical manufacturers, (latest edition); importers, or employers evaluating (ii) International Agency for Research chemicals shalLdescribejn.writinglhe on Cancer (IARC) Monographs (latest procedureTlhcy use to determine the editions): or hazards'of tHe~c'hemical~they~evaluate. (iii) 29 CFR Part 1910. Subpart Z, Toxic and Hazardous Substances. Occupational Safely and Health Administration. The written proved fires are to be made available, upon request to employees, their designated representatives, the Assistant Secretary and the Director. The written description may be Note.--The Registry of Toxic Effects of Chemical Substances published by the National Institute for Occupational Safety incorporated into the written hazard communication program required under paragraph (e) of this section. and Health indicates whether a chemical has (e) Written hazard communication been found by NTP or IARC to be a potential program. (1) Employers shall develop carcinogen. and implement a written hazard (5) The chemical manufacturer, importer or employer shall determine the hazards of mixtures of chemicals as communication program for their workplaces which at least describes how the criteria specified in paragraphs follows: (i) If a mixture has been tested as a whole to determine its hazards, the results of such testing shall be used to determine whether the mixture is hazardous; (ii) If a mixture has not been tested as a whole to determine whether the mixture is a health hazard, the mixture shall be assumed to present the same health hazards as do the components which comprise one percent (by weight or volume) or greater of the mixture, except that the mixture shall be assumed to present a carcinogenic hazard if it contains a component in concentrations of OT percent or greater (0< (g). and (h) of this section for labels and other forms of warning, material safety data sheets, and employee information and training will be met and which also includes the following: (1) A list of the hazardous chemicals known to be present using an identity that is referenced on the appropriate material safety data sheet (the list may be compiled for the workplace as a whole or for individual work areas); (ii) The methods the employer will use to inform employees of the hazards of non-routine tasks (for example, the cleaning of reactor vessels), and the hazards associated with chemicals contained in unlabeled pipes in their work areas; and. which is considerecTto be a carcinogen (iii) The methods the employer will under paragraph (d)(4) of this section; use to inform any contractor employers (iii) If a mixture has not been tested as with employees working in the a whole to determine whether the employer's workplace of the hazardous mixture is a physical hazard, the chemicals their employees may be chemical manufacturer, importer, or exposed to while performing their work, employer may use whatever and any suggestions for appropriate scientifically valid data is available-to protective measures. evaluate the physical hazard potential (2) The employer may rely on an of the mixture; and existing hazard communication program (iv) If the employer has evidence to to comply with these requirements, indicate that a component present in the provided that it meets the criteria mixture in concentrations of less than established in this paragraph (e). one percent (or in the case of (3) The employer shall make the carcinogens, less than 0.1 percent) could written hazard communication program be released in concentrations which available, upon request, to employees, would exceed an established OSHA their designated representatives, the permissible exposure limit or ACCIH Assistant Secretary and the Director, in accordance with the requirements of 29 CFR 1910.20(e). (f) Labels and other forms of warning. (1) The chemical manufacturer, importer, or distributor shall ensure that each container of hazardous chemicals leaving the workplace is labeled, lagged or marked with the following information: (1) Identity of the hazardous chemical(s): (ii) Appropriate hazard warnings: and (iii) Name and address of the chemical manufacturer, importer, or other responsible party. (2) Chemical manufacturers, importers, or distributors shall ensure that each container of hazardous chemicals leaving the workplace is labeled, tagged, or marked in accordance with this section in a manner which does not conflict with the requirements of the Hazardous Materials Transportation Act (18 U.S.C. 1801 et seq.) and regulations issued under that Act by the Department of Transportation. (3) If the hazardous chemical is regulated by OSHA in a substancespecific health standard, the chemical manufacturer, importer, distributor or employer shall ensure that the labels or other forms of warning used are in accordance with the requirements of that standard. (4) Except as provided in paragraphs (f)(5) and (f)(6) the employer shall ensure that each container of hazardous chemicals in the workplace is labeled, tagged, or marked with the following information: (i) Identity of the hazardous chemical(s) contained therein; and (ii) Appropriate hazard warnings. (5) The employer may use signs, placards, process sheets, batch tickets, operating procedures, or other such written materials in lieu of affixing labels to individual stationary process containers, as long as the alternative method identifies the.containers to which it is applicable and conveys the information required by paragraph (0(4) of this section to be on a label. The written materials shall be readily accessible to the employees in their work area throughout each work shift. (6) The employer is not required to label portable containers into which Occupational Safety & Health Reporter (Sec. 1910.1200(f)(6)] A2323* TOXIC SUBSTANCES S-191 31:8655 hazardous chemicals are transferred paragraph (d)(4) of this section shall be (xii)The name, address and telephone from labeled containers, and which are listed if Ihe concentrations are 0.1% or number of Ihe chemical manufacturer, intended only for the immediate use of greater: and, importer, employer or other responsible the employee who performs the transfer. (2)The chemical and common name(s) parly preparing or distributing the (7) The employer shall not remove or of all ingredients which have been material safety data sheet, who can deface existing labels on incoming determined to present a physical hazard provide additional information on the containers of hazardous chemicals, when present in the mixture; hazardous chemical and appropriate unless (he container is immediately (ii) Physical and chemical emergency procedures, if necessary. marked with the required information. characteristics of the hazardous (3) If no relevant information is found (B) The employer shall ensure that chemical (such as vapor pressure, flash for any given category on Ihe material labels or other forms of warning are point); safety data sheet, the chemical legible, in English, and prominently (iii) The physical hazards of the manufacturer, importer or employer displayed on the container, or readily hazardous chemical, including the preparing the material safety data sheet available in the work area throughout potential for fire, explosion, and shall mark it to indicate that no each work shift. Employers having reactivity: applicable information was found. employees who speak other languages (iv) The health hazards of the (4) Where complex mixtures have may add the information in their hazardous chemical, including signs and similar hazards and contents (i.e. the language to the material presented, as symptoms of exposure, and any medical chemical ingredients are essentially the long as the information is presented in conditions which are generally same, but the specific composition English as well. recognized as being aggravated by varies from mixture to mixture), the (9)The chemical manufacturer, exposure to the chemical: chemical manufacturer, importer or importer, distributor or employer need (v) The primary route(s) of entry, employer may prepare one material not affix new labels to comply with this (vi) The OSHA permissible exposure safety data sheet to apply to all of these section if existing labels already convey the required information. (g) Material safety data sheets. (1) Chemical manufacturers end importers shall obtain or develop a material safety data sheet for each hazardous chemical they produce or import. Employers shall have a material safely data sheet for each hazardous chemical which they use. (2] Each material safety data sheet shall be in English and shall contain at limit, ACCIH Threshold Limit Value, and any other exposure limit used or recommended by the chemical manufacturer, importer, or employer preparing the material safety data sheet, where available: (vii) Whether the hazardous chemical is listed in the National Toxicology Program (NTP) Annual Report on Carcinogens (latest edition) or has been found to be a potential carcinogen in the International Agency for Research on similar mixtures. (5) The chemical manufacturer, importer or employer preparing the material safety data sheet shall ensure that the information recorded accurately reflects the scientific evidence used in making the hazard determination. If the chemical manufacturer, importer or employer becomes newly aware of any significant information regarding the hazards of a chemical, or ways to protect against the hazards, this new least the following information: Cancer (IARC) Monographs (latest fi] The identity used on the label, and, editions), or by OSHA: information shall be added to the material safety data sheet within three except as provided for in paragraph (f) (viii) Any generally applicable months. If the chemical is not currently of this section on trade secrets: precautions for safe handling and use being produced or imported the (A] If the hazardous chemical is a which are known to the chemical manufacturer, importer or employer chemical manufacturer or importer shall add the information to the material single substance, its chemical and common name(s); preparing the material safety data sheet, safety data sheet before the chemical is including appropriate hygienic practices, introduced into the workplace again. (B] If the hazardous chemical is a protective measures during repair and (6) Chemical manufacturers or mixture which has been tested as a maintenance of contaminated importers shall ensure that distributors whole to determine its hazards, the equipment, and procedures for clean-up and manufacturing purchasers of chemical and common name(s) of the of spills and leaks; hazardous chemicals are provided an ingredients which contribute to these (ix) Any generally applicable control appropriate material safety data sheet known hazards, and the common measures which are known to the with their initial shipment, and with the name(s) of the mixture itself: or, chemical manufacturer, importer or first shipment after a material safety (C] If the hazardous chemical is a employer preparing the material safety data sheet is updated. The chemical mixture which has not been tested as a data sheet, such as appropriate manufacturer or importer shall either whole: engineering controls, work practices, or provide material safety data sheets with (/) The chemical and common name(s) personal protective equipment; the shipped containers or send them to of all ingredients which have been (x) Emergency and first aid the manufacturing purchaser prior to or determined to be health hazards, and procedures: at the time of the shipment. If the which comprise 1% or greater of the (xi) The date of preparation of the material safety data sheet is not composition, except that chemicals material safety data sheet or the last provided with the shipment, the identified as carcinogens under change to it; and. manufacturing purchaser shall obtain A23239 12-15-03 [Sec. 1910.1200(g)(6)] PuWished 6y THE BUREAU OF NATIONAL AFFAIRS INC.. Washington. O.C. 20037 29 31:8656 REFERENCE FILE one from the chemical manufacturer, importer, or distributor as soon as (i) Methods and observations that may be used to delect the presence or nurse, regardless of the existence of a written statement of need or a possible. release of a hazardous chemical in the confidentiality agreement. The chemical (7) Distributors shall ensure that work area (such as monitoring manufacturer, importer, or employer material safety data sheets, and updated conducted by the employer, continuous may require a written statement of need information, are provided to other distributors and manufacturing monitoring devices, visual appearance or odor of hazardous chemicals when end confidentiality agreement, in accordance with the provisions of purchasers of hazardous chemicals. being released, etc.); paragraphs (i) (3) and (4) of this section, (8) The employer shall maintain (ii) The physical and health hazards of as soon as circumstances permit. copies of the required material safety the chemicals in the work area; (3) In non-emergency situations, a data sheets for each hazardous chemical (iii) The measures employees can take chemical manufacturer, importer, or in the workplace, and shall ensure that to protect themselves from these employer shall, upon request, disclose a they arc readily accessible during each hazards, including specific procedures specific chemical identity, otherwise work shift to employees when they are the employer has implemented to permitted to be withheld under in their work area(s). protect employees from exposure to paragraph (i)(l) of this section, to a (9) Material safety data sheets may be hazardous chemicals, such as health professional (i.e. physician, kept in any form. Including operating appropriate work practices, emergency industrial hygienist, toxicologist, or procedures, and may be designed to procedures, and personal protective epidemiologist) providing medical or cover groups of hazardous chemicals in equipment to the used: and. other occupational health services to a work area where it may be more (iv) The details of the hazard exposed employee(s) if: appropriate to address the hazards of a communication program developed by (i) the request is in writing; process rather than individual the employer, including an explanation (ii) The request describes with hazardous chemicals. However, the of the labeling system and the material reasonable detail one or more of the employer shall ensure that in all cases safety data sheet, and how employees following occupational health needs for the required information is provided for can obtain and use the appropriate the information: each hazardous chemical, and is readily hazard information. accessible during each work shift to employees when they are in their work area(s). (10) Material safety data sheets shall also be made readily available, upon request, to designated representatives and to the Assistant Secretary, in accordance with the requirements of 29 CFR 1910.20(e). The Director shall also be given access to material safety data sheets in the same manner. (h) Employee information and training. Employers shall provide employees with information and training on hazardous chemicals in their work area at the time of their initial assignment, end whenever a new hazard is introduced into their work area. (1) Information. Employees shall be informed of: (i) The requirements of this section; (11) Any operations in their work area where hazardous chemicals are present; and. (i) Trade secrets. (1) The chemical manufacturer, importer or employer may withhold the specific chemical identity, including the chemical name and other specific identification of a hazardous chemical, from the material safety data sheet, provided that; (1) The claim that the information withheld is a trade secret can be supported; (ii) Information contained in the material safety data sheet concerning (he properties and effects of the hazardous chemical is disclosed; (iii) The material safety data sheet indicates that the specific chemical identity is being withheld as a trade secret; and. (iv) The specific chemical identity is made available to health professionals, in accordance with the applicable provisions of this, paragraph. (2) Where a treating physician or nurse determines that a medical (A) To assess the hazards of the chemicals to which employees will be exposed: (B) To conduct or assess sampling of the workplace atmosphere to determine employee exposure levels; (C) To conduct pre-assignment or periodic medical surveillance of exposed employees; (D) To provide medical treatment to exposed employees; (E) To select or assess appropriate personal protective equipment for exposed employees; (F) To design or assess engineering controls or other protective measures for exposed employees: and, (C) To conduct, studies to determine the health effects of exposure. (iii) The request explains in detail why the disclosure of the specific chemical identity is essential and that, in lieu thereof, the disclosure of the following information would not enable (iii) The location and availability of emergency exists and the specific the health professional to provide the the written hazard communication chemical identity of a hazardous occupational health services described program, including the required list(s) of hazardous chemicals, end material safely data sheets required by this section. (2) Training^Employee training shall include at leash chemical is necessary for emergency or first-aid treatment the chemical manufacturer, importer, or employer shall immediately disclose the specific chemical identity of a trade secret chemical to that treating physician or in paragraph (ii) of this section: (A) The properties and effects of the chemical; (B) Measures for controlling workers' exposure to the chemical; (C) Methods of monitoring and Occupational Safety a Health Reporter [Sec. 1910.1200(i){3Xiii)(C)) A2324C TOXIC SU8STANCS S-191 31:8657 analyzing worker exposure to the chemical: and, (0) Methods of diagnosing and (iii) Include evidence to support the provided without an undue risk of harm claim that the specific chemical identity to the chemical manufacturer, importer, is a trade secret; or employer. treating harmful exposures to the chemical: (iv) The request includes a description of the procedures to be used to maintain (iv) State the specific reasons why the request is being denied: and.. (v) Explain in detail how alternative information may satisfy the specific (11) If. following the issuance of a citation and any protective orders, the chemical manufacturer, importer, or employer continues to withhold the the confidentiality of the disclosed information: and. (v) The health professional, and the employer or contractor of the health professional's services (i.e.. downstream employer, labor organization, or individual employer), agree in a written confidentiality agreement that the health professional will not use the trade secret information for any purpose other than medical or occupational health need without revealing the specific chemical identity. (8) The health professional whose request for information is denied under paragraph (i)(3) of this section may refer the request and the written denial of the request to OSHA for consideration. (3) When a health professional refers the denial to OSHA under paragraph information, the matter is rcfcrrable to the Occupational Safely and Health Review Commission for enforcement of the citation. In accordance with Commission rules, the Administrative Law fudge may review the citation end supporting documentation in camera or issue appropriate protective orders. (12) Notwithstanding the existence of a.trade secret claim, a chemical the health need(s) asserted and agree (i)(8) of this section. OSHA shall manufacturer, importer, or employer not to release the information under any consider the evidence to determine if: shall, upon request, disclose to the circumstances other than to OSHA, as (i) The chemical manufacturer, Assistant Secretary any information provided in paragraph (i)(6) of this importer, or employer has supported the which this section requires the chemical section, except as authorized by the claim that the specific chemical identity manufacturer, importer, or employer to terms of the agreement or by the is a trade secret: make available. Where there is a trade chemical manufacturer, importer, or (ii) The health professional has secret claim, such claim shall be made employer. supported the claim that there is a no later than at the time the information (4) The confidentiality agreement medical or occupational health need for is provided to the Assistant Secretary so authorized by paragraph (i)(3)(iv) of this the information: and. that suitable determinations of trade section: (1) May restrict the use of the information to the health purposes indicated in the written statement of need; (ii) May provide for appropriate legal remedies in the event of a breach of the agreement including stipulation of a reasonable pre-estimate of likely damages; and. (iii) May not include requirements for the posting of a penalty bond. (5) Nothing in this standard is meant to preclude the parties horn pursuing non-contractual remedies to the extent permitted by law. (6) If the health professional receiving the trade secret information decides that there is a need to disclose it to OSHA. the chemical manufacturer, importer, or employer who provided the information shall be informed by the health professional prior to. or at the same time (iii) The health professional has demonstrated adequate means to protect the confidentiality. (10) (i) If OSHA determines that the specific chemical identity requested under paragraph (i)(3) of this section is not a bona fide trade secret, or that it is a trade secret but the requesting health professional has a legitimate medical or occupational health need for the information, has executed a written confidentiality agreement, and has shown adequate means to protect the confidentiality of the information, the chemical manufacturer, importer, or employer will be subject to citation by OSHA. (11) If a chemical manufacturer, importer, or employer demonstrates to OSHA that the execution of a confidentiality agreement would not provide sufficient protection against the secret status can be made and the necessary protections can be implemented. (13) Nothing in this paragraph shall be construed as requiring the disclosure under any circumstances of process or percentage of mixture information which is trade secret. (j) Effective dates. Employers shall be in compliance with this section within the following time periods: (1) Chemical manufacturers and importers shall label containers of hazardous chemicals leaving their workplaces, and provide material safety data sheets with initial shipments by November 25.1985. (2) Distributors shall be in compliance with all provisions of this section applicable to them by November 25. 1985. (3) Employers shall be in compliance with all provisions of this section by as. such disclosure. potential harm from the unauthorized May 25.1985. including initial training (7) If the chemical manufacturer, importer, or employer denies a written request for disclosure of a specific chemical identity, the denial must: disclosure of a trade secret specific chemical identity, the Assistant Secretary may issue such orders or impose such additional limitations or for all current employees. Appendix A to S 1910.1200--Health Hazard Definitions (Mandator}') (i) Be provided to the health conditions upon the disclosure of the Although safety hazards related to the professional within thirty days of the requested chemical information as may physical characteristics of a chemical request; be appropriate to assure that the can be objectively defined in terms of (ii) Be in writing; occupational health services are testing requirements (e.g. flammability). 12-15-83 A23241 (Appendix A to Sec. 1910.1200] Published by THE BUREAU OF NATIONAL AFFAIRS INC.. Washington. O.C. 20037 31  31:8658 REFERENCE FILE health hazard definitions are less Similarly, the term chronic effect is precise and more subjective. Health often used to cover only carcinogenicity, hazards may cause measurable changes teratogenicity, and mutagenicity. These in the body--such as decreased effects arc obvious a concern in the pulmonary function. These changes arc workplace, but again, do not adequately generally indicated by the occurrence of cover the area of chronic effects, signs and symptoms in the exposed excluding, for example, blood employees--such as shortness of breath, dyscrasias {such os anemia), chronic a non-mcasurable. subjective feeling. bronchitis and liver atrophy. Employees exposed to such hazards The goal of defining precisely, in must be apprised of both the change in measurable terms, every possible health body function and the signs and effect that may occur in the workplace symptoms that may occur to signal that os a result of chemical exposures cannot change. realistically be accomplished. This does The determination of occupational not negate the need for employees to be health hazards is complicated by the informed of such effects and protected fact that many of the effects or signs and from them. symptoms occur commonly in non* Appendix B. which is also mandatory, occupationally exposed populations, so outlines the principles and procedures of that effects of exposure sre difficult to hazard assessment. separate from normally occurring For purposes of this section, any illnesses. Occasionally, a substance chemicals which meet any of the causes an effect that is rarely seen in the following definitions, as determined by population at large, such as the criteria set forth in Appendix B are angiosarcomas caused by vinyl chloride health hazards: exposure, thus making it easier to ascertain that the occupational exposure 1. Carcinogen: A chemical is was the primary causative factor. More considered to be a carcinogen if: often, however, the effects are common, (a) It has been evaluated by the such as lung cancer. The situation is International Agency for Research on further complicated by the fact that Cancer (IARC). and found to be a most chemicals have not been carcinogen or potential carcinogen: or adequately tested to determine thetr (b) It is listed as a carcinogen or health hazard potential, and data do not potential carcinogen in the Annual exist to substantiate these effects. Report on Carcinogens published by the There have been many attempts to National Toxicology Program (NTP) categorize effects and to define them in (latest edition); or, various ways. Generally, the terms (c) It is regulated by OSHA as a "acute" and "chronic" are used to carcinogen. delineate between effects on the basis of severity or duration. "Acute" effects usually occur rapidly as a result of 2. Corrosive: A chemical that causes visible destruction of, or irreversible alterations in, living tissue by chemical short-term exposures, and are of short action at the site of contact. For duration. "Chronic" effects generally example, a chemical is considered to be occur as a result of long-term exposure, corrosive if. when tested on the intact and are of long duration. skin of albino rabbits by the method The acute effects referred to most described by the U.S. Department of frequently are those defined by the Transportation in Appendix A to 49 CFR American National Standards Institute Part 173. it destroys or changes (ANSI) standard for Precautionary irreversibly the structure of the tissue at Labeling of Hazardous Industrial the site of contact following an exposure Chemicals (Z129.1-1982)--irritation, period of four hours. This term shall not corrosivity, sensitization and lethal refer to action on inanimate surfaces. dose. Although these are important 3. Highly toxic: A chemical falling health effects, they do not adequately within any of the following categories: cover the considerable range of acute (a) A chemical that has a median effects which may occur as a result of lethal dose (LDm) of SO milligrams or occupational exposure, such as. for less per kilogram of body weight when example, narcosis. administered orally to albino rats weighing between 200 and 300 grams each. (b) A chemical that has a median lethal dose (LDm) of 200 milligrams or less per kilogram of body weight when administered by continuous contact for 24 hours (or less if death occurs within 24 hours) with the bare skin of albino rabbits weighing between two and three kilograms each. (c) A chemical that has a median lethal concentration (LGo) in air of 200 parts per million by volume or less of gas or vapor, or 2 milligrams per liter or less of mist. fume, or dust, when administered by continuous inhalation for one hour (or less if death occurs within one hour) to albino rats weighing between 200 and 300 grams each. 4. irritant: A chemical, which it not corrosive, but which causes a reversible inflammatory effect on living tissue by chemical action at the site of contact. A chemical is a skin irritant if. when tested on the intact skin of albino rabbits by the methods of 10 CFR 1500.41 for four hours exposure or by other appropriate techniques, it results in an empirical score of five or more. A chemical is an eye irritant if so determined under the procedure listed In 16 CFR 1500.42 or other appropriate techniques. 5. Sensitizer A chemical that causes a substantial proportion of exposed people or animals to develop an allergic reaction in normal tissue after repeated exposure to the chemical. 6. Toxic. A chemical falling within any of the following categories: (a) A chemical that has a median lethal dose (LDm) of more than SO milligrams per kilogram but not more than 500 milligrams per kilogram of body weight when administered orally to albino rats weighing between 200 and 300 grams each. (b) A chemical that has a median lethal dose (LDm) of more than 200' milligrams per kilogram but not more than 1.000 milligrams per kilogram of body weight when administered by continuous contact for 24 hours (or less if death occurs within 24 hours) with the bare skin of albino rabbits weighing between two and three kilograms each. (c) A chemical that has a median lethal concentration (LCae) in air of *23242 Occupational Safety 4 Health Reporter {Appendix A to Sec. 1910.1200] 32 31:8660 flEFERENCE FILE Clinical Toxicology of Commercial Products Miscellaneous Documents--National CONFERENCE Cleason. Cosselin and I lodge Institute for Occupational Safety and KNVIROLINE Casarett and Doull's Toxicology: The Basic Health LABORDOC Science ofPoisons 1. Criteria for a recommended standard NTIS Doul), Klaasscn. and Amdur. Macmillan Publishing Co.. Inc.. New York. NY Industrial Toxicology, by Alice Hamilton ond Harriet L Hardy Publishing Sciences Croup. Inc.. Acton. MA Toxicology of the Eye. by W. Morton Croat ' * * Occupational Exposure to 2. Special Hazard Review* 3. Occupational Hazard Assessment 4. Current Intelligence Bulletins Bibliographic Data BAses " POLLUTION SSIE Chemical Information System (CIS). Chemical Information Systems Inc. 721S Yorke Road. Baltimore. MD 21212 Charles C Thomas. 301-327 East Lawrence Service Provider and File Home Structure S Nomecla lure Search System Avenue. Springfield. IL Recognition of Health Hazards in Industry William A. Burgess, John Wiley and Sons. 60S Third Avenue. New York. NY 101S8 Chemical Hazards of the Workplace Nick H. Proctor and James P. Hughes. J. P. Lipincolt Company. 6 Winchester Terrace. New York. NY 10022 Handbook ofChemistry ond Physics Chemical Rubber Company. 16001 Cranwood Parkway. Cleveland. OH 44126 Threshold Limit Volues for Chemical Substances ond Physical Agents in the Workroom Environment with Intended Chonges American Conference ofCovemmental Industrial Hygienists. 6S00 Clenway Avenue. Bldg. D-5. Cincinnati. OH 45211 Bibliographic Retrieval Services (BR9J, Corporation Park. Bldg. 702. Scotia. New York 12302 Acute Toxicity (RTECSJ Clinical Toxicology of Commercial Products ACRICOLA BIOSIS PREVIEWS CA CONDENSATES ,, Oil and Hazardous Materials Technical Assistance Data System Natiunal Library of Medicine. Department of CA SEARCU Health and Human Services. Public DRUC INFORMATION Health Service. National Institutes of MEDLARS Health. Bethesda. MD 20209 MEDOC Toxicology Data Bank (TDB) NT1S MEDLltt POLLUTION ABSTRACTS TOXLINE SCIENCE CITATION INDEX SSIE Lockheed--DIALOG. Lockheed Missiles & CANCER LIT RTECS Space Company. Inc.. P.O. Box 44481. San Francisco. CA 94144 $1910.1495 Source of standards. ACRICOLA BIOSIS PREV. 1972-PRESENT Section 1910.1000- 41 FR 50-204.50. except Note.--The following documents are on BIOSIS PREV. 1969-71 for TXbh Z-J, tSw sale by the Superintendent of Documents. CA CONDENSATES 1970-71 source at wXtoh IS U.S. Government Printing Office. CA SEARCH 1972-76 American Nattoni* Washington. D.C 20402. CA SEARCH 1977-PRESENT Standards Institute, Occupational Health Cuidelines CHEMNAME Z3T atflrw NIOSH/OSHA (NIOSH Pub. No. Bl-123) CONFERENCE PAPERS INDEX [Sec. 1910.1499 added at 40 FR 21073. May 2S. 19751 AIIOSH/OSHA Pocket Guide to Chemical Hozords FOOD SCIENCE & TECH. ABSTfL FOODS ADLIBRA s mo.lsoo Standards orgimlinrtVaie. NIOSH Pub. No. 76-210 INTL. PHARMACEUTICAL ABSTR. Specific standards of the following .ox^ Registry of Toxic Effects ofChemical NTIS gnnlzfttlons have been referred to In this Substances POLLUTION ABSTRACTS subpart. Copies of the standards may be U.S. Department of Health and Human SCISEARCH 1976-PRESENT obtained'from the issuing organization. Services. Public Health Service. Center SCISEARCH 1974-77 for Disease Control. National Institute for SSIE CURRENT RESEARCH Occupational Safety and Health (NIOSH SDC--ORBIT. SDC Search Service. American Conference of Governmental loanstrial HygSenUU.. 1014 Broadway Pub. No. 60-102) Department No. 2230. Pasadena. CA Cincinnati'. Ohio 45303 The Industrial Environment--Its Evaluation 91051 American Rational Btandanda Lxatltede ond Control ACRICOLA u.m nmnrtxir U.S. Department of Health and Human BIOCODES NewYork. Hew Tart 10016 Services. Public Health Service. Center for Disease Control. National Institute for Occupational Safety and Health (NIOSH Pub. No. 74--117) 8I0SIS/BI06973 CAS6771/CAS7276 CAS77 CHEMDEX (Section 1910.1500 added at 40 FR 23073, May 28. 1975: corrected at 43 FR 57601, December 8, 1978. to delete listing of National Tire Protection Association] Occupational Sataty t Health Reporter [Sec. 1910.1S00] A2324 4 34 PRODUCT SAFETY COMMUNICATIONS COMMITTEE MEETING Danbury, Connecticut - December 9, 1981 ATTENDEES: R. W. Rebholz - Metals Division W. G. Whitehead - Home and Automotive S. H. Henry - Linde Eleanor Jensen - Linde J. S. Lovell - Agricultural Products S. R. Converse - Battery Products M. D. Michaud - Distribution M. G. Manetti - Law Department L. A. Crisorio - HS&EA R. N. Wheeler, Jr. - HS&EA I. Classification of Carcinogens Mr. L. A. Crisorio reviewed the Health Effects Review Process (HERB) . The Health Effects Review -Board has the- primary responsibility for gathering input trom all interestedTcomponents departments and outside organizations to screen materials for re view, request studies and other data on the material and to recom mend classification of the hazard with necessary exposure stan dards. (See Figure I) The Toxicity Assessment and Advisory Committee (TAAC) is one of the resources available to HERB for use in classification of hazardous materials and in recommending exposure standards. TAAC is composed of scientific, medical and safety personnel whose function is to impartially review available health effects data on a material and recommend classification of the material as a particular type of health hazard. In the case of carcino gens the classifications and their definitions to be used by TAAC are shown on Figure II. Persons assigned to TAAC are shown on Figure III. Most of these persons have been functioning as the disbanded MUCAT Committee. A2324S 2- - _Concern was--exp.r_es-S.ed that_TAAC._might consider. only substances in its classification of materia Is as carcinogens and~not consider'"the product which could.be relatively non7 fiazardousT-by iyfrttie~~crf its fora, the concentration-of-the car'giftogen in thelproduct-.or _th'lack of a route for., human exposure. An addition to the TAAC defiriit'ibris of carcino gens 'such as the following: Product Classification. Individual products containing the carcinogenic substances identified by TAAC will be evaluated considering the substance in the product it or the products fora, the substances concentration in the product and the probability of human exposure by various routes. A product containing a carcinogen may be exempted from the labeling and other requirements if the carcinogen is present .in very low -concentrations, if the product fora obviates possible human exposure or if other factors render it not a carcino genic hazard. The Health Effects Review Board is a new concept and its operating procedures are not well defined. Currently, HERB is working on criteria for screening materials, i.e., do they require HERB action and review or not? Persons as signed to HERB are shown on Figure IV. There are no per manently assigned component members since these are to vary depending on the subject for board action. When a material is selected for review interested component personnel will be notified so that they may attend and provide their input. COMMENTS: Concern was expressed as to how many governmental de partments require MSDS as defined by OSHA Form-20. The De partment of Defense was identified as requiring the OSHA Form-20. Linde was concerned as to TAAC initiating material inquiry and classification independently of HERB' Home and Automotive would like to see a common vo cabulary for medical, toxicity data and warning statements for labels and MSDS. II. Chronic Health Hazard Labeling - Carcinogens Policy Draft Mr. Crisorio introduced a new draft policy on car cinogen labeling (Figure V), replacing the draft provided in his letter dated December 1, 1981. The change was made to comply more fully with Category I policy. &23246 The Committee discussed the proposed policy at length and modified it as shown in Figure VI. Other comments offered for consideration are: 1. Proposed Policy - Page 1 Purpose and Background The first three paragraphs might be modified slightly and used as a general purpose background for an overall chronic health hazard labeling policy since other chronic hazards will be the subject of further policies. 2. The TAAC definition of animal carcinogen should be modified to include the following: If there is sufficient credible evidence ' to suggest that a chemical substance which could otherwise be classified as an animal carcinogen may not be carcinogenic in man (metabolism studies, etc.), such chemical substance need not be labeled pursuant to this policy. However, in such instances, the appropriate information shall be noted in the MSDS and other relevant product safety communications. 3. An item 5 should be added to the policy such as: If there is sufficient credible evidence ' to suggest that a chemical substance which could otherwise be classified as an animal carcinogen, may not be carcinogenic in man {metabolism studies, etc.), such chemical substance need not be labeled pursuant to this policy provided HERB and TAAC concur. However, in such instances, the appropriate information shall be noted in the MSDS and other relevant product safety communications. The Committee will meet January 15, 1982 in Danbury to review the new draft of the Chronic Health Hazard - Carcinogen Labeling Policy incorporating these changes as well as the draft Distributor Policy. RNWjr/dh A ttachments A 23 2 4 7 Figure I D e c is io n ^ u w c .-u . . * . iu jllh K fte c ti R eview Proceaa O w< < sO (0 rt o n aa C C3 S3 a (0 & ns *< o O (0 p 53 (0 tffff-ttttn *D O **0- O ft CW fftt* fftt rOr ft 3fftt Ort Oft 3 no o3 fftt O rr ft ft ft 3 3 O_*3O O3 f3t O3 ft ft ft 3 33 fftt c * rt o c wa O c *1 nft oo eo on a m o3^- 03 9 ft O>*M*%0 >Q, <ft H- "O o 3 rr ft ft sa rftr OM rftr 9 ft IB rn Q. f*t* M<* n co ir ft fat <ft CO ft9 O 0ft fftt f0t ft rr co ft O rr <M3 r-- h- -- fCt fftt IB 3O f1t- fWftt* cg fet (A O *ff1tt 9 von coo nA 3 H-H 'O 3 Of O <D rr 3 B `ft CD O 3 *fftt0 Mo3f3ftt IT Ofrtt 0. rt- r- 0*0 3 nco o-*co - H-ft o ft* 3 O *f*t1 HO oc T Q OA H CO CO fOt fftt oo 11 S M oO K3 (ft O. fftt* Cft ss3 ft rftr fftt* 00 fKt**f0t Kft* M ft (fftt M ft VQ MCft rr f0t K n o o 3ft 3rr 2ft CL ft* n H *3 H*. ofXt* OH w0o *< ^VV VVp> c ft ft w sown Orr 3 fQt fcnt . h*> a * O mo 3 m3 C ao vhn *O0*30 > O 3 o o o ft C ft 0 rr rr *D IB ** rt O ft 3 Ocft A23248 DEFINITIONS Known Human Carcinogen - Applied to any material WHERE THERE IS SUFFICIENT CREDIBLE AND RELEVANT EVIDENCE, BASED PRINCIPALLY ON OBSERVATIONS OF EXPOSED HUMAN POPULATIONS, WHICH DEMONSTRATES THAT THE MATERIAL HAS CAUSED CANCER IN HUMANS, Suspect Human Carcinogen - Applied to any material FOR WHICH THERE IS SUFFICIENT CREDIBLE EVIDENCE, BASED ON ANIMAL AND OTHER RELATED STUDIES, THAT THE MATERIAL IS CARCINOGENIC IN LABORATORY ANIMALS, AND FOR WHICH OTHER RELEVANT INFORMATION IS AVAILABLE TO DETERMINE THAT THE MATERIAL MIGHT ALSO BE CARCINOGENIC FOR HUMANS, Animal Carcinogen - Applied to any material for WHICH THERE IS SUFFICIENT CREDIBLE EVIDENCE, BASED ON ANIMAL AND OTHER RELATED STUDIES, THAT THE MATERIAL IS CARCINOGENIC IN LABORATORY ANIMALS, BUT FOR WHICH THERE IS INSUFFICIENT EVIDENCE TO ALLOW A DETERMINATION OF THE POTENTIAL FOR CARCINOGENICITY IN HUMANS. Figure II A23243 TOXICITY ASSESSMENT & ADVISORY COMMITTEE (TAAC) Dr= B. Ballantyne - Chairman - Director - Corporate Applied Toxicology Dr. S. G, Austin - Corporate Medical Epidemiology Mr. N. E. Bolton - HS&EA - Industrial Hygiene Mrs. S. D. -Conner - Corp. Applied Toxicology Mr. R. W. Cope - HS&EA - Industrial Hygiene Mr. L. A. Crisorio - HS&EA - Product Safety Mr. N. W. Gaines - HS&EA - Occupational Health Dr. R. H. Garman - Bushy Run Res. Cntr. - Pathology Mr. R. G. Hanlon - HS&EA - Industrial Hygiene Dr. W. C. Kuryla - Corp. Allied Toxicology Dr. A. A. Lang - Corporate Medical Dept. Dr. T. A. Lincoln - Corp. Medical Director Dr. M. J. Makowsky - Corporate Medical Dept. Dr. R. S. Slesinski - Bushy Run Res. Cntr. - Cytogenetics Dr. T. R. Tyler - Corporate Applied Toxicology TAACOperating components bring candidate substances to for consideration of its toxicological properties. Figure III A2325C ) HEALTH EFFECTS REVIEW BOARD . Mr. A. 6. Voress - Chairman - HS&EA - Occupational Health Director Dr. B. Ballantyne - HS&EA - Applied Toxicology Mr. N. E, Bolton - HS&EA - Industrial Hygiene Mr. R. A. Butler - Corporate Law Dept. Mr, T. W. Carmody - HS&EA - Product Safety Director Dr. F. R, Frank - HS&EA - Busy Run Research Center Director Mr. N. W. Gaines - HS&EA - Occupational Health Dr. D. L. Heywood - HS&EA - Product Safety Gov't Regulations Dr. T. A. Lincoln - HS&EA - Corporate Medical Dept, Mr. J. W. Whittlesey - Corporate Law Dept. Representative from principally affected components Figure IV A2325 I PURPOSE/BACKGROUND One element of an effective precautionary labeling program is inclusion of warnings for chronic health hazards that potentially might arise from improper use and/or exposure to the involved hazardous chemical substance. This policy concerns the hazard warnings that should be used for those hazardous chemical substances that have demonstrated carcinogenic potential. Some state governments and the Federal Government have exercised authority in mandating hazard warnings for hazardous chemical substances demonstrating carcinogenic activity. This policy will supplement and not supplant such .authority. Precautionary labeling is a part of our product safety program furnishing customers with information about the potential hazard and the safe handling of our products and this policy is merely an extension of our Precautionary Labeling Policy. The labeling of carcinogens are treated as a special class for several important reasons; they have a long latency period before the adverse effects are observable and the determination of material possessing carcinogen potential is complex and requires the judgement of traine'd professional toxicologists and/or doctors. Proper product labeling is essential for the safe use of hazardous chemical substances including carcinogens and products demonstrating potential to cause other chronic health hazards. The purpose of this policy is to provide a basis for management programs to identify potential carcinogen materials and provide for their uniform labeling. The Corporate Product Safety Policy states: "Union Carbide will: "Regularly review product safety information and in the light.of new experience of Union Carbide and / others,- - and, if appropriate, - - - - , modify / the product safety communications." ' It further states: A23252 "Comply with all applicable governmental laws and regulations relating to product safety." Fi/:iidc \l 1. Evaluation of potential human health effects is the responsibility of the Health Effects Review Board (HERB). 2. HERB shall, if appropriate, classify particular chemical substances in one of three categories of carcinogen potential; Known Human Carcinogen Suspect Human Carcinogen Animal Carcinogen 3. All government mandated carcinogen labeling requirements will be complied with and in the event that the UCC labeling requirement.is different, the government mandated requirement-shall be followed, unless there is a need for both labeling requirements. 4. The precautionary labeling of chemical substances which have been evaluated and classified by HERB shall contain the appropriate hazard warning statement: Category Warning Statement Known Human Carcinogen Human Cancer Agent Suspect Human Carcinogen Suspect Cancer Agent Animal Carcinogen Has caused Cancer in Laboratory Animals The elements of the precautionary label of carcinogens shall be placed as follows: (a) Signal Word; Label will have Signal Word appropriate to most significant hazard. If cancer is the major risk WARNING is the appropriate Signal Word. (b) Placement: Directly following Hazard Statement for the most immediate and serious risks (such as flammability, poisoning and serious burns); or directly under product name if no more serious product hazards are involved. A23253 I carbide I CORPORATE PRODUCT SAFETY MANUAL SUBJECT CHRONIC HEALTH HAZARD LABELING CARCINOGENS SECTION Policies/Communrcations DATE 11/30/81 APPLIES TO B UNITED STATES PAGE 3 of 3 INTERNATIONAL (c) Name: Known or Suspect Human Carcinogens or Animal Carcinogens must be designated by their common or usual chemical name which may be in addition to trade or code names. (d) Precautionary Measures: Appropriate list of precautions depending on whether risk is from skin absorption# inhalation and/or ingestion. SCOPE This policy applies to all parts of OCC except to products and services of the Nuclear Division regulated by the Department of Defense, Department of Energy or Nuclear Regulatory Committee and to all affiliates worldwide in which UCC has a greater than fifty percent equity interest and is recommended for application in affiliates of fifty percent or less equity interest. &232S4 PURPOSE/BACKGROUND One element of an effective precautionary labeling program is inclusion of warnings for chronic health hazards that potentially might arise from improper use and/or exposure to the involved hazardous chemical substance. This policy concerns the hazard warnings that should be used for those hazardous chemical substances that have demonstrated carcinogenic potential. Some state.governments and the Federal Government have exercised authority in mandating hazard warnings for hazardous chemical substances demonstrating carcinogenic activity. This policy will supplement and not supplant such .authority. Precautionary labeling is a part of our product safety program furnishing customers with information about the potential hazard and the safe handling of our products and this policy is merely am extension of our Precautionary Labeling Policy. The labeling of carcinogens are treated as a special class for several important reasons; they have a long latency period before the adverse effects are observable and the determination of material possessing carcinogen potential is complex and requires the judgement of traine*d professional toxicologists and/or do'ctors. Proper product labeling is essential for the safe use of hazardous chemical substances including carcinogens and products demonstrating potential to cause other chronic health hazards. The purpose of this policy is to provide a basis for management programs to identify potential caxcinogen materials and provide for their uniform labeling. The Corporate Product Safety Policy states: "Union Carbide will: "Regularly review product safety information and in the light.of new experience of Union Carbide and f others,- - -* and, if appropriate, - - - - , modify i the product safety communications." It further states: "Comply with all applicable governmental laws and regulations relating to product safety." C ? r* iir> r WT Icarbide CORPORATE PRODUCT SAFETY MANUAL SUBJECT CHRONIC HEALTH HAZARD CARCINOGENS LABELING SECTION --rr vg ^------- Policies/Communications DATE 12/i/81 PAGE 2 of 3 APPL1EST0 B UNITED STATES INTERNATIONAL 1. POLICY 1. Evaluation of potential human health effects is the responsibility of the Health Effects Review Board (HERB). 2. HERB shall, if appropriate,' classify particular products in one of three categories of carcinogen potential; Human Carcinogen Suspect Human Carcinogen Animal Carcinogen 3. All government mandated carcinogen labeling requirements shall be complied with. If UCC labeling requirements are more stringent than the government's additional labeling.statements may be added provided they do not detract from or contradict the government mandated label. 4. Unless governmental regulations mandate otherwise, the precautionary labeling of products which have been evaluated and classified by HERB shall contain the appropriate hazard statement: Category Warning Statement Human Carcinogen Cancer Hazard Suspect Human Carcinogen Suspect Cancer Hazard Animal Carcinogen Causes Cancer in Some Laboratory Animals The elements of the precautionary label of carcinogenic products shall be placed as follows: (a) Signal Word: Label will have Signal Word appropriate to most significant hazard. If cancer is a risk, no signal word for it is required. (b) Placement: Directly following Hazard Statement for the most immediate and serious risk (such as flammability, poisoning and serious burns); or directly under product name if no more serious product hazards are involved.1 A23256 .aoSSb corporate product safety manual SUBJECT CHRONIC HEALTH HAZARD CARCINOGENS LABELING SECTION Policies/Communications DATE 12/9/SI PAGE 3 of 3 APPLIES TO B UNITED STATES O INTERNATIONAL (c) Name: Human or Suspect Human Carcinogens or Animal Carcinogens must be designated by their common or usual chemical name which may be in addition to trade or code names. (d) Precautionary Measures: Appropriate list of precautions depending on whether risk is from skin absorption, in halation and/or ingestion. 5. If there is sufficient credible evidence to suggest that a chemical substance which could otherwise be classified as an animal carcinogen, may not be carcinogenic in man (metabolism studies, etc.), such chemical substance need not be labeled pursuant to this policy provided HERB and TAAC concur. However, in such instances, the appropriate information shall be noted in the MSDS and other relevant product safety communications. SCOPE This policy applies to all parts of UCC except to products and services of the Nuclear Division regulated by the Department of Defense, Department of Energy or Nuclear Regulatory Committee and to all affiliates worldwide in which UCC has a greater than fifty percent equity interest and is recommended for application in af filiates of fifty percent or less equity interest. A23257 UNION CARBIDE I 1ST OF CARCINOGENS AND TERATOGENS {See Reverse Side) NOTES OF EXPLANATION: 1. A material is included pn this list on the basis of a detailed review of published toxicological, medical and epidemiological information by the Union Carbide Corporate "Mutagen, Carcinogen and Teratogen (HuCaTT) Committee". 2. This listing is periodically reviewed. New entries are made, or existing ones modified, when the MuCaTT Committee determines that there is sufficient credible evidence for such an action. 3. (a) The entries marked with an asterisk [*] are those which have not yet been formally reviewed and verified by the MuCaTT Committee as part of a current updating procedure. Those so marked will be reviewed during I98I. (b) No entry indicates that information has not been located to allow a decision on carcinogenic or teratogenic potential. (c) The symbol [--) indicates that the available evidence is sufficient to determine that a material does not cause a given effect. DEFINITIONS: 1. Known Human Carcinogen means a substance for which there is sufficient credible evidence to determine that the material has caused cancer in humans. 2. Suspect Cancer Agent means a substance for which there is credible scientific evidence, based on animal and other related studies, that the material is carcinogenic in laboratory animals, but for which there is insufficient evidence that the substance causes cancer in man. 3- Teratogen means a chemical substance or physical agent which causes abnormalities in structural and/or functional development curing gestation. A232S8 substance * . 2-Acetylamino f1uorene ii Acrylonitrile 1 Page 1 of__ 9 . UNION* CAR3IDZ LIST OF CARCINOGENS AND TERATOGENS (See Reverse Side for Explanations and Definitions) 0 1 UJ t CAS IDENTIFICATION NUMBER 53-96-3 CARCINOGENICITY 1 1 TERATOGENICITY EXPOSURE STANDARO FOLLOWED BY UNION CARBI0E (SOURCE) Suspect cancer aaent Teratogen* No exposure (UCC) Known human carcinogen Teratogen* 2 ppm 10 ppm C (OSHA) I ! ! i 1 4-Ami nodi phenyl 92-67-1 Asbestos 1 1 r ! Benzene i i i i Ii Benzidine i! 1 Benzidine-derived ! ayes it 1 | Bis-2-Chloroethyl j etner i ! 3is-2-Chloroethy1; 2-naphthylamine 1332-21-4 71-43-2 92-87-5 111-44-4 494-03-1 Known human carcinoqen Known human ca rcinogen Known human carcinoaen Teratogen Known human carcinogen Known human careinogens Suspect cancer* agent 1 Known human* carcinogen i 1 i 1 No exposure (UCC) 2 Fibers/cc >5 long (ACGIH) j 10 ppm (OSHA) No exposure (UCC) No exposure (UCC) 0.1 ppm (UCC) ! 1 No exposure j (UCC) 1 1 1 UC CORPORATE MuCaTT C0.RMI.TTEE/5-20-3l A23259 Page 2 of 9 UNION CAPSIDS LIST OF CARCINOGENS AND TERATOGENS (See Reverse Side for Explanations and Definitions) * SUBSTANCE . * r Bls-Chloromethyl ether ' ; ; Cadmium CAS IDENTIFICATION NUMBER CARCINOGENICITY 542-88-1 Known human carcinoaen 1 1 ! I j7440-43S-9uspect cancer agent i TERATOGENICITY Teratogen* EXPOSURE STANDARD FOLLOWED BY UNION CARBIDE (SOURCE) 0.001 ppm (ACGIH) 40 ^g/m^ 200 yg/m3 C (ucc) j i t 1 1 l i Carbon tetra chloride 56-23-5 Suspect cancer agent Teratogen* 2 ppm 4 ppm C (ucc) 1 Chloroform ! 1 i i ! Chloroprene i J i Chromates of Lead and Zinc i i l [ Chromium-6 | compounds i(See footnore below) i i ! Di-Sec-'outoxyacetophenone 67-66-3 126-99-8 68109-57-9 Suspect cancer agent Teratogen* Suspect cancer* aaent Suspect cancer agents Suspect cancer agents Suspect cancer* agent 2 ppm 4 ppm C (UCC) 1 pom (UCC) 0.05 mg/m3 (as Cr) (ACGIH) 1 ug/m3 (UCC) j No skin or oral contact (UCC) "ootncce: Structurally related oraano-cnromates should be regartec as suspect cancer agents (such as Bis-trionenyI silyl chromate.) -C CORPORATE MuCaTT COMMIT7EE/5-20-81 A2326C SUBSTANCE 3,3'-Dichlorobenzidine (and salts) Page 3of9 UNION CAR3IDE LIST OF CARCINOGENS AND TERATOGENS (See Reverse Side for explanations and Definitions) CAS IDENTIFICATION NUMBER 91-94-1 CARCINOGENICITY TERATOGENICITY i Suspect cancer agent(s) EXPOSURE STANDARD FOLLOWED BY UNION CARBIDE (SOURCE) No exposure (UCC) J j | | ! .ii i j l Diethyl sulfate 64-67-5 Oiisopropyl sulfate 2973-10-6 Dimethyl acetamide 127-19-5 4-0imethy 1 ami no azobenzene Oimethyl formamide 60-11-7 68-12-2 Oimethyl sulfate 77-78-1 i i Suspect cancer agent Suspect cancer* agent Teratogen* Suspect cancer agent Teratogen* Suspect cancer agent 1 ppm No skin or oral contact (UCC) j ! ; T ppm No skin or oral contact (UCC) i i ) j i ! i j 10 ppm j No skin contact j (OSHA. UCC) i No exposure j (OSHA) I i i 10 ppm | No skin contact ; (OSHA. UCC) 1 i 0.1 ppm No skin or oral contact (ACGIH, UCC) ! t!~ CORPORATE MuCa i > COHM! 0-81 A23261 c:; Page k of 9 UNION CARS IOE LIST OF CARCINOGENS AND TERATOGENS (See Reverse Side for Explanations and Definitions) SU3S7ANCE . 1 Dimethyl sulfoxide l,A-Dioxane Dioxin CAS IDENTIFICATION NUMBER CARCINOGENICITY 1 11 TERATOGENICITY 67-68-5 Teratogen* 123-91-1 Suspect cancer agent 17^6-01-6 Suspect cancer* aaent Teratogen EXPOSURE ! STANDARD | FOLLOWED 3Y UNION CARBIDE (SOURCE) j ! ! 1X i [ 10 ppm ; No skin contact i (UCC) : 1 1 50 ppm No skin or oral contact (UCC) No exposure (UCC) i i 1 ! Oripoienes-A,B,C i i j Epichlorohyarin i 1 i- epoxy resin ERL-277^ 106-89-8 25068-38-6 Suspect cancer agents Suspect cancer aqent Suspect cancer agent 600 No skin contact (UCC) 0.5 ppm (UCC) 10 ppm No skin or oral contact (UCC) i Epoxy resin j ERL-A205 J i i 2386-90-5 Suspect cancer agent - 1 i 1 1 10 ppm No skin or oral contact (UCC) i \ j r uCaTT COMHIT 20-31 *2326? (See Reverse Side for Explanations and Definitions) f"". " ---- - - '---- SUBSTANCE CAS IDENTIFICATION NUMBER CARCINOGENICITY TERATOGENICITY EXPOSURE STAN0AR0 FOLLOWED 3Y UNION CARBIDE (SOURCE) Epoxy resin ERL-4206 106-87-6 Suspect cancer agent 10 ppm No skin or I oral contact (ucc) Epoxy resin ERL-4234 26616-47-7 Suspect cancer agent 10 ppm No skin or oral contact (UCC) ' 1i j { j i I 2-Ethoxyethanol (CELLOSOLVE) 110-80-5 Teratogen 100 ppm (ACG1H) Ethylene dibromide 106-93-4 Suspect cancer aqent . 0.i ppm (UCC) Ethylene dichloride 107-06-2 Ethyleneimine 151-56-4 Ethylene oxide 75-21-8 Suspect cancer agent Suspect cancer agent Suspect cancer agent 5 ppm (UCC) i j | No exposure 1 (0SHA) m 5 P?ra (ucc) | Ethylene thiourea i 2-Ethyl hexyl j acrylate s 'See fooT'ors belowl 56-45-7 103-11-7 Suspect cancer* agent i Suspect cancer ; agent j1 Teratogen* No exposure (UCC) 5 (UCC) rrovis ional iy induced, pending completion cf ;nc i nter-Incustry Acrylate Study Committee's chronic toxicity study review. *1 \ j *! ! i j 'JC CORPORATE MuCaTT COMMITTEE/p-ZO-cl *23263 Page 6 of ? UNION CARS IDE LIST OF CARCINOGENS AND TERATOGENS (See Reverse Side for Explanations and Definitions) SU8STANCE Chlorodifiuorome thane (fiuoroca rbon-22) Formaidenyde Formamide Fuel oil residues Hexa f1uoroace tone CAS IDENTIFICATION NUMBER 75-45-6 50-00-0 75-12-7 634-16-2 CARCINOGENICITY Suspect cancer agent Suspect cancer agents EXPOSURE STANDARD j j TERATOGENICITY FOLLOWED EY j UNION CARBIDE 1 - - - - - - - - - -(- -S- - O- - -U- - -R- -C:- -E- - )- - - - - - - - - - - - - - - - - : 1 ! Teratogen* 1000 ppm 1 j (UCC) 1 1| Teratogen* 1 2 ppm 1 (ACGiH) . 1 ! 1 J 20 ppm j No skin contact (ACGIH, UCC) i ! No skin contact i (UCC) Teratogen* ! 0.1 ppm No skin contact (ACGIH, UCC) Hydrazine 302-01-2 Suspect cancer agent (-) Lead Mercury, Alkyl compounds Methyl chloromethyl ether 7433-92-1 107-30-2 (-) Teratogen Teratogens* Known human carcinogen 1 1 : i [ 50 MS/*} (OSHA) No exposure (UCC) Ho exposure (OSHA) i 1 1 l ' 'JC CORPORA'71 MuCaTT COMMITTEE/5-20-31 A23264 LIST OF CARCINOGENS AND TERATOGENS {See Reverse Side for Explanations anc Definitions) SUBSTANCE . Methylenei diani1ine 1 1 ! g." Naphthyl amine i i I i {5-Naphtny i amine CAS IDENTIFICATION NUMBER 101-77-9 13^-32-7 91-59-3 iooentyi glvcol ; ciacrv:a:e ! 11 j Nickel, ! Inoraanic compounds 1 (1 4-Nitrodioneny1 1 1 2-N1troprooane 2223-82-7 92-93-3 79-66-9 N-Nicrosoamine compounds j N-Nitroso- !;d i me thv i amne ! !! 62-75-9 CARCINOGENICITY 1 i Suspect cancer* j agent i ! TERATOGENICITY 1 EXPOSURE STANDARD FOLLOWED 3Y UNION CARBIDE (SOURCE) 0.1 ppm No skin or oral contact (acgih. uc:5 ! Suspect cancer* aqent Known human carcinoaen j No exposure 1 (OSHA) i ii 1 Nc execs..'* 1 Suspect cancer* agent I 'lo ><!' :; ore; contact ! UCC Suspect cancer agents j 'j Known human carcinoaen j ! Suspect aoent cancer ! ! Suspect cancer* agents ; Suspect cancer : agent 1 rng/m^ (OSHA) Teratogen* No exoosure (OSHA) I j 25 ppm 1 (NIOSH) 11 I j No skii :r i oral contact j *..urs>- No exocser* (OSHA. ! | ! | : t \ ! | j ! | : { t | > UC CCPPC COMMITTEE-' 5-20-81 A2326b ' SU3STANCE Perch loroethyl ene Pitches t LIST OF CARCINOGENS AND TERATOGENS (See Reverse Side for Explanations and Definitions) CAS IDENTIFICATION NUMBER 127-18-1* CARCINOGENICITY Suspect cancer* agent i TERATOGENICITY EXPOSURE STANDARD FOLLOWED BY UNION CAR8I0E (SOURCE) Teratogen* 10 ppm Ip pom C (UCC) i \ | j 1 j ) Suspect cancer agents 200 >ig/m3 600 >*g/m3 c No skin contact (ACGIH, UCC) i Polychlorinated biphenyls (PCBs) Suspect cancer agents Teratogens* 1 j*g/n>3 3C No skin contact (UCC) Polycyclic aromatic hydro carbon compounds Suspect cancer agents Teratogens* 200 >ig/m3 600 >ig/m3 c No skin contact (UCC) p-Propielactone Pyrolysis fuel oil 57-57-8 Quench oil i i 1 Suspect cancer aqent Suspect cancer agent Suspect cancer agent 1 1 j ! ( No exposure (0SHA) 200 ^ig/m^ i 600 *g/ra3 C No skin contact (UCC) 200 >ig/m3 600 ^g/m3 c Mo skin contact (UCC y nr Vv v vrtr "uCa ci CCMnI'TEE/5'20-31 A23266