Document 9JQxjr1G3kEeeV6JRvL6Gka5L

HASKELL LABORATORY FOR TOXICOLOGY AND INDUSTRIAL MEDICINE DATE: May 8, 1984 TO: E. E. SWAIN* JR. FINISHES & FABRICATED PRODUCTS DEPT. B-5204 PROJECT MR - 7254 PART I TITLE: SUBCHRONIC (2-WEEK) INHALATION TOXICITY OF PAINT FORMULATED WITH DESMODURN SLK UD INFO AJ>R Authority is requested to undertake the study identified above and de scribed as follows: i The subchronic Inhalation toxicity of DesmodurN will be investigated in Medical Research Project MR-7253. In medical research project MR-7254, the subchronic inhalation toxicity of a paint formualted with DesmodurN will be evaluated. A brief outline of the study design includes: male Crl:CD rats will be exposed; exposures will be 6 hr/d, 5 d/w for 2 w; t test groups will include 3 exposure concentrations of paint formulated with DesmodurN; paint without DesmodurN; and an air control; and 0 and 14 days post exposure evaluations of hematology, urinalysis, and pathology. Forecast month and year: Amount requested: $ 53,000 Experiment to start: within 3 mo. of receipt Previously authorized: $ -0- Experiment to end: 1 month after start Expended through: $ -0- Final report to issue: 1 yr. from end (date) General Ledger & Sub-Account to be Request for study made by: E. E. Swain charged CLASSIFIED: R&D ___ OTHER ___ (check appropriate classification) If this request meets with your approval, please enter the GENERAL LEDGER A SUB-ACCOUNT TO BE CHARGED and the CLASSIFICATION, have the original authorized and return to HASKELL LABORATORY, CONTROL SECTION. The additional K&O>* I K> ON 41 0-1 hi ao zwtoi axoaa o U1 <0% H<a o H N ca * CM 8 O' o o H *0 O' 10 M5 O' 8 O' o N CM n H *0 -4 1ft H CJ C--Oi Ng N 1C0J CO H Oto' 40 s0 --1 N O* CO O' o b N o O' hi N 1ft O o hi H o co N 10 0 0J N Kl M H CM CJ 40 *0 w eft PASE 401 SEPTEMBER 1986 HASKELL LABORATORY CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT s Si =13 lm ia >- UO. Uci). IHnI z ^ ZHZ wia wO iOl oo Ohiil IX M Q ZO UQ HX XH 3OM WHZ I o o o o N ft iun 3 N 30811.01 DUP050446596 CENTRAL RESEARCH S DEVELOPMENT DEPARTMENT HASKELL LABORATORY SEPTEMBER 1966 PASE AOS *6 1<0 o(0 Mo O J<-- HLU Ht coe u. bUi fe 1IU lii z =F3Z 0.g uoo O>h-lti QfHO SgXh hx WP8 IU I <)a> :p I* 3O J <Io?zo * I-- :l * K :* gU a lit W :g h Iw- I K$ o oo B & 6ui og 3n: bg x IU H >4 uO. -Hms* *rHdof If) R oH) PROJECT* * IS SUBJECT TO 57. OVERRUN LIMITATION N* I0ft (051 O. I aa r* m o*8 1 DUP050446597 < IO 1ft O' C\J ft o <0 ft X CO o UJ CD a < IU CL CO o-i O s g < Z o >- g iS hi g. IU 9 U. I HZ s St- I o IT) z CM < f*. Q t<1 UJ Nw < Of os o o E< Ui t< *Q O Hftl ft CM CO (ft O' o o o c* Ift ft* o to O' ft to N* p* 0 ft H HIft o ft CM si rs N Ift CM CO 4 O' to ft ft Pi No Ooft' N O* O' tros ift ft o t^o1 o h H ft CM CO tft CO ft CM fs. to CM pi CM ft ft H CO o u Qa r> as *3i- a0:*zm0 Utoi Oo opX I uz 3g z Ui as U *H < is. 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OVERRUN LIMITATION ItOfl O' K o f* O s CJ CQ DUP050446599 5 N W O'* o c* 0* D vt CO UI o o* to *0 ro N :g H *<0r I-f<) co N * ON OH ,, <tt I z fK M CJ 0 8 P E I W IU MO B o O X NOO' PA6E 395 JULY 1906 HASKELL LABORATORY UJ N CJ O' a eg CO * tt o * Ph m4 <43 N HH sO *4 0 (N N CJ O' *0 N A 10 CO O' o O' CO o A M CJ *0 to *0 O H eg CJ A CM A CJ A csr N S0 (0 o z gs ^5 g wa. O U. 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OVERRUN LIMITATION lCENTRAL RESEARCH DEVELOPMENT DEPARTMENT HASKELL LABORATORY JUNE 1966 DUP050446602 * * PROJECT IS SUBJECT TO 5X OVERRUN LIMITATION CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT HASKELL LABORATORY JUNE X986 PAGE 3 % hio iu :5c a i 11O00* toi O 02 * au UuJ $ oo a* in (I*U* ft a ui 3 IU 02 iu Ui CL X <* UJ H rH <* u. ro Kl oH p 2 IU H IU in O' ro to UJ N- Jv * # PROJECT IS SUBJECT TO 5`A OVERRUN LIMITATION K) & 1 io ON W sa gO H<zt ooKO DUP050446603 < a O TCJ <0 CM CO 10 O' o o A o O' UI o O' o HI O' p N m, <a s H $ H 1H0 CM CO H o -o- ft N W io CJ CO CO O' **0 Hi <? H h o CJ g e & HI HI Ift CM HI CO *- CO o I*. (a c j *o *< hi 8 o: 10 oaa PAGE 392 MAY 1966 HASKELL LABORATORY wo H HJ <5 w Bt <** UO. UQ. ^ui .h- U}- Hi Z =wfa3gz f<*u. CIfOl sO h- r*t H"2 >6 CJ N0> ft O' O' CJ o o* *fot to CM CJ CJ CM CJ H- CO O' sr O' CO Ui I s 5 < CO Sx UI I x NHI *2 Hd1 to to Oro' wCh &8 K St as XX I CO u 12 Xf1iU g X 0 1 8 >x- 5 3o 3> iu LU 5o o0 o X Z DUP050446604 CENTRAL RESEARCH DEVELOPMENT DEPARTMENTt MAY 1966 PA6E 393 ha 3<S-3 ig -gu. rU a sOr'- to 8 Meo Zo z :fe * UaJt : go <Ia HASKELL LABORATORY CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT 0 1 V) 1U ** ZUttJ UJ uUat.l & Cr*M. S o g * UJ a. xu:i d- m K> s S Ig Out C H1*o1>*1 3S g oS s DUP050446605 D-6150 e <o tO IU I g < X 0 Pi K 3! S 3IS Of DC o O U. < ic:CO ** u. e u. -J UJ I-- i UJ d T 3* < uUXi W<M "-S u- a g >- <0 x 1 H ui s s 1 i-l X X Iow CO H 3 fe 3 si* O in X CM <. 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OVERRUN LIMITATION DUP050446606 APRIL 1986 HASKELL LABORATORY PAGE s zo HQ < wh- lit -J < < -I Xz 3c w ck o u. ^ IU *8 ^ , 11. 1 Mw ILSO' u- o uoo HZ >- s(0 Ohm o; h d Xo S(JxHXP OH 0> H 3 * aUh<-l ip in 8 N Hi eg :g O * <o I 3 i oo> :p -Oa-' 4OU0 s dp HZ (Q O Of : at :6 rIo CO OK1' Sg P gH * *a :gu 3O V) 2 LaU CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT I N b UoJl I I < UJ % UJ -- O rt H S2 iSmu -i*ft a- --J ro ro u j n rs. K1 g P g Oo s w2O g ut 6 U*0J c3o V7 CJ o ** DUP050446607 tO 8 P PAGE 579 MARCH 1986 HASKELL LABORATORY W1<-<xzMzoJ~X12UUJ LQUK<-rOpDJLCcJ fXwc- UUt8. 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UJ HI (0 UJ HP u < UJ H <0 tu H P U < UJ H (0 uj p o < LU M P H* CO UJ H* P u <c UJ CO CO X u UJ 1- o UJ CO > ot CO X u UJ H > o >19 o --J o x p CL WJ 1 >IS -J o x H* < a r* l > CD o J o X H < a DC 3 CK o 0 _J *2 CL x UJ J <( H* o H* oh(O X< nH*: CPtoO hO* Oa DUP050446608 CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT HASKELL LABORATORY MARCH 1906 PAGE 375 UJ 5 Q 'P H ocn L> II H2 35 < wa o u. --' u. a M , u. Ui IU hz- | 3WZ I< C\J B. EC W Uu O ag z > <n OhUl xa wCJ a umx X hOM WI-2 3 o o o H <1 ' boIU I o Ocf' fc; 8 IU IU . <H K> Kl O' I g uUi z H* z uj xa { O X Sa ch in r- #* PROJECT IS SUBJECT TO BV. OVERRUN LIMITATION K> g P E DUP050446609 PA6E 366 thu- < r- CJ Q ,, CJ CIfOt :p gO' 10 O' * to O' o IS 'SM H vl H IA H CJ e a* >o c5 CO r-l On' ho a rH CO o r- C4 rHA FEBRUARY 1986 HASKELL LABORATORY t<- tHu- -J < < .J 11 mb ** OU. u8. 1C , u. tu h i tu *z 3<l4 H<Qf. 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CUttBMaUB<XahouOl s i 2 t-o ttota<o IU a: o H _t IU > tu J < to 2t CL mJ < o M zM *J o >a <_j < (0 X CUJl I- 1 < a u o CO z o u > Of to o UJ h ti. > b < c to i (0 z o u > & to Q J Ul H IL O < IU X B IU > o to UJ M a s bto UJ o < H M > Ul mJ mJ < (0 (0 UJ M a s to UJ o < H UJ > _IU! < (0 to UJ H H CO Ul a -* >B 3 < to X o UJ K CO Ul M O P to UJ 5 u < M w h o .> UJ IU to -J to -J UJ < o to HI >1 B UJ o to UJ .u to <> u H OS to z 55 Ul UJ hw -1 < CO X u UJ H t o UJ to > B to X u IU w o < UJ X B I>U o >ts --ot o f < a H H > UJ J v B< < to ) >o omJ o X H < a. > s _r < <0 X u UHJ 1 >- o o < CL a o C<O IU 1 CL J < h* e K H o $ CO s to to OM B IU IU -J U- O CO fit Ha ** DUP050446610 CENTRAL RESEARCH ft DEVELOPMENT DEPARTMENT CENTRAL RESEARCH fc DEVELOPMENT DEPARTMENT HASKELL LABORATORY FEBRUARY 1986 PAGE 365 5 HQ H tt O U> r*. U- 8 X IU u j j-- i UJ Z 3i w< Z cj w a. az> iu a u oo Hx > Z O hut a: h o x (J mxh W3 * to(<U ip so mJ X ife iu K :S < o O' Kl KI O' tn CJ c N N W 00 1 CL Ul 3? Ul 0x. Ul (0 PROJECT* * IS SUBJECT TO BY. OVERRUN LIMITATION Ul 111 in K *0a1-i moo* g DUP050446611 DUP050446612 few*""' e5 oo AHO CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT HASKELL LABORATORY Ih-- UaJ 1h 1ao. i oo 8s JANUARY 1986 CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT HASKELL LABORATORY j JANUARY 1986 PAGE 335 itt 5a io- o PS 35 *i1 "* * U. U- LU h I LU Z 3MZ I< OJ CL IL O 2umOho>-lUorto 3wa Xo UH ggfci 10 H 3 :fe * LU * DC :S *U i 8o O' H N a- (s0 s S| : UJ CL :g 4J UJ H< (0 SP |8 *3 * 511 ** 3 UJ u. 3UJ O H 'O 8 P o u o u< W -< o -a a 13 oo in UJ M e D os PROJECT IS SUBJECT TO BY. OVERRUN LIMITATION Hi DUP050446613 PA6E 631 DECEMBER 1965 > a* NCJ * ej in0 Oe' in O' Oor*' xpH H ipCnHO O N-No a<0 sm 90 &09 KfO-li CNCOO H 90 CO CO W C*O COh 90 H IU o NCsOr iCnOo ooor>*l po9H0> tpiHH90 0o9 N90o9 CO *K in co OO'' C9O0 s CO lA CO sCOr 0&9 HASKELL LABORATORY CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT "" B O5XoHhZP OKpH' sUCXtuOi CL 2 I I I0IL. 1 iiu s 5 CbOJ tc<oe X 8._tuJIi <07 CD gU UzI s M U <CO U 9 UXI s 8 > g SUI Nin to Min iMn H CM O' SCrNwO 15 HE s sMH U>JI _i <CO CUMOI 5PCO tu 5u< H I>I.UUJl _<<10 UCHOi 5 to iu 5 >- 5<CO 5UHi cUMP5P(0oi UI 5u< 1uUC"Oi ` HM >Ui MCIo>aUCUOOJ _J -<C1O CUCOJi Ht(0t IHU uhi C<jO XCJ IS 1 uUCOJ >ato zLUt->J Q<tXaI>oUuC. JCo>oD<a HH >I-UJ >a<_<C~Oj i C>D_5j o p <a 8 in i oI- 0 K) Iu- iu 1 S S -i OT Z CD Cfl a0 x * & OUI! U1I i 1 I I 8 DUP050446614 CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT HASKELL LABORATORY DECEMBER 1985 PAGE 832 :g :p eg UJ o O' mh- aui 35 su ^Ul .t U|- U3J Mz z WCLg o oil po M iu DOH wI K> o eo r4 O $ csl N ft S UJ UJ c. 2 <r H uo. S t UJ &H M- Oto' N o *a o iS 8 W I OH 2 o 2 H CJ UJ W w g s DUP050446615 DUP050446616 (OH3 $ oo H*0 N. N K O E CENTRAL RESEARCH A DEVELOPMENT DEPARTMENT HASKELL LABORATORY NOVEMBER 1985 CENTRAL RESEARCH A DEVELOPMENT DEPARTMENT HASKELL LABORATORY NOVEMBER 1985 3! WK O U. U. 0 Ss* wag w u. p poo OhlU XU gsg wPS IuU I U * UJ r K) W =:g DUP050446617 * * PROJECT IS SUBJECT TO S'/. OVERRUN LIMITATION PAGE 627 OCTOBER 1985 H- * <a l*. <M CM CO O' o ip m o H sou < 3g Of * a o* So rs. 1A <0CSJ O' K> CO o* o* o o* IA nn h c<m1 UJ 5* N W O' o CM <0 o St m o * H *0 o O' N 3O' :p H NO O' e oO' co CMo CM W O' 4* D-6150 in O' p 2. Ul O HO SP <3 5 ma o u. ^U.99 ^ IL 1 =fS2 O. g IL O uoo HE z > to OhUJ XO O' 10 ro <mr ior #-* O' sinf CM N N HASKELL LABORATORY PROJECT* * IS SUBJECT TO SZ OVERRUN LIMITATION CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT -O i in X CM N < rK) o UJ Jor Nw a UJ o *"> o X X M >- M >- M M UJ sin z Ul a. UJ pu. so s s(0 fc z UJ X UJ aJ UJ o UJ to < X u CL _toJ, < X M 5 in UJ CO x < O' m t3 CL X o u i _j bJ CO < X to UJ <2> x X u h u UJ O' H a o <c Ul X X Ul > O X H < IL J UJ J * in <c a. mi O CO z 8 > a in Q --l Ul M U. >* 5 -J < 0) 1 CO z a o > x in a mi Ul H IL O < Ui X x UJ > o in UJ H tC--O UJ hz> u < w w > Ul _J <cr> CO UJ H g cn ui H X u <c mi Ul > UJ J _J < to CO Ul w h* to Ul H* Xa < XM 3 H -U > < to IcUo - UJ -i X CO mi u UJ < Ui o CO h* H cn > a; 1 UJ UJ u M CO UJ g to <> 10 o X M to UJ z HXX Xu u u UJ Ul <H -J < to X u UJ t1 o UJ <0 *> O' CO X ula i- o < Ul X X UJ > o >CO moJ o x p < a. H > Ul mi > <X mJ < (0 1 V tD aO O X F < X >X < mi < CO x o UJ J- 1 > <3 o o X H<c- ? o a UJ >3 UJ X cti X o <to UI CO zui X X UJ ~J p o h to o O' in _j o o F XLU IL to z < fV F DUP050446618 CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT HASKELL LABORATORY OCTOBER 1985 PAGE 626 ho & ou is s UJ oz :S U inI 90 3 U o IQ O *S wag o H O r*. to a0z 1 2 UJ CL X r-1 to S H s K N IS. 5 fcC> O' | 3 O U out <c a4 oi uu a 1 M UJ m a3 xa 1 *# PROJECT IS SUBJECT TO S'/. OVERRUN LIMITATION DUP050446619 PAGE 612 SEPTEMBER 1985 2O MO H IU <-l H<< --J X3 XX WK ' iOL U< .* *Ui H. **t UJ Z _ 3cwImH<a. Z3o' U- 3 oM oo2 zO >H- twil XK UH Q o3mlxwO-3xhH- i*n xO NCM < ,M f0u-i HaO 2x 1I UJ ; i* ! 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Hm 1ID ZCO ui a. xiu 10 <XuXX (<Xu9 3 XCL X CQ<CD Xu <a tu X X ui > o X H < CL < (_> K z uM a H -J UJ > ui -j -J < CO f <0. < uM z M O >- 3 < (0 X u UI K X h < CL _J < Ol-t z M u < IU XD IU O X<uo0 >Dto touu u. <>a <1i0 CO gu >itfa) a-U*UHJj. o <c Ui X X UJ > o CO UJ a fCO XO<IHU H w :> UI _I J < CO CO ui s CO UHDu<-i H Ui > Ui -4 -1 < (0 CO LLi B CO UH3u<*i > c 3 < CO X CJ Ui H CO ui CO 3IHu<U- M w }o> UJ UI CO ' CO Ui I o >oo0 1 < to Xu s s o HX N. o 3Ot1>OXt1f tOo um-) s . to o CO z<aH a ** HASKELL LABORATORY CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT DUP050446620 CENTRAL RESEARCH DEVELOPMENT DEPARTMENT HASKELL LABORATORY SEPTEMBER 1985 PAGE 613 Mo f- UJ <H 3x 53 zx h n: O u. --' U. <* tu UJ UJ Sz~ I 31 W< Z c j o. a w u. a ooa Svg O H UJ DJWQ 3uT UW X to X P DOW V> I-- X > UJ -Q fe Ou - *U <o ip O' O' trt UO UJ d <H0 Zo -c z UJ '> c3ar cj * ^< (0 Q KKO*ll *x a : UJ x 1 5 r- r* ro uI-oU 2HN I ai CL < UJ ID z o (w0 z XUJ Ul 1wft Kk -l m 8 P J O IK C3 U Qa 8 PROJECT IS SUBJECT TO BX OVERRUN LIMITATION DU P050446621 PAGE 605 AUGUST 1935 &IO O' (D Z DC H 3 8 JtuO D-6I50 PS 5< 5 Xn XX MK. O U. U. *0 . u. UJ I- t uj Z 2wI <Hac. Z a "u.g ag gpa D!HQ Xo <a r% <C*V l g oo* o Oift' o vO M Oo' r-. <h hi sO tn D U 1 K XUi CK :g O * ui :5 n <li0t :p ou01 a 1x1 -S X ~l H MX 0 O * o N fM >o rH o Wi OJ h* <0 <0 (0o H N is. <0 sO N O' O' 'O' JO o rl O o O' o* O rs *0h* M eo rH M <M *o H w <h so *fj .0 O' -i CSI W W NW Is* s0f O<*' HASKELL LABORATORY PROJECT IS SUBJECT TO 5X OVERRUN LIMITATION CENTRAL RESEARCH fc DEVELOPMENT DEPARTMENT DU P050446622 CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT HASKELL LABORATORY AUGUST 1985 PAGE 606 * <a ioon eg <o s: UaJ 2 O -<MI<--JC OUH<-Jj 2M D O U. ~ u- ^ u. UiyJ zj-- t 3I m H<ac. 2 a aM2 uo_ >- asSo> O 1-- w X0U oWW O X 3W>OH$ SHH ha< M ig s 8 W03 ZOz > zu> UJ :5c o *a o: k> Ch u I (0 UJ a to zw CXULl uo. r-a<tr~nt <Hwd3-- r~i to oaCL -UzsUUJJJJ rr1K*fl.tl dwO *K PROJECT IS SUBJECT TO 5Z OVERRUN LIMITATION DUP050446623 DU P050446624 oCO HX P3C Sow I o H *6 N P5 S g CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT HASKELL LABORATORY JULY 1965 CENTRAL RESEARCH fc DEVELOPMENT DEPARTMENT HASKELL LABORATORY JULY 1985 PAGE 603 UJ *H O `P Iu u lol. Ij iti ggi to ! # * o H mo h * <o i ttoo I vl O' os ot 0 Ul U g Uo2 z Unsl ui la. ui tt st* O m 2= CM < r- tv a to m N hw O tt UJ o -> X o ta3 O. < X * Ul ri rt LL to to o rl H (0 tz Ul z H *d* UJ to p to to UJ P- r- to s po: cl e_o u< MO 'O *3 Ig htoi e> O O S k h PROJECT IS SUBJECT TO 5JJ OVERRUN LIMITATION DUP050446625 HI P rIrotttl a o itUl < Mr* mto & Ul t Ul a* to O' gl> CM Kl Hi 0 O H Ul r*i CM CO H O o * N h IO SA CM <0 * co H O' HI 0* 0 0 H H e CM <0 O' o * r- N O' O' * HI HI N U| a CM <0* o o rH 0 HI e CM 0 jn 2O' Ul IO M>H Nh I n z o IH O >- K< UJ H : P 5 -<J < -J X3 tt zs Hi fiC O O It. 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X UJ g H- HI O Ul mj to P cu IU Urn 2 < Ul DUP050446626 CENTRAL RESEARCH DEVELOPMENT DEPARTMENTi HASKELL LABORATORY JUNE 1985 PAGE 60S < `O tnfIt ei O' 9* 1 <H <3 ii u. *a ' =f3z D.g slu. a z >- 25 OHUI amo xu CJ h x g (ft H 3 I O O' UJ s V) gg o a : UuJ Xo s (ft o Ul UaJ UJ u. Ual sin 1df*t CIVJ r- e R Kl t? P E 3S K UJ K> DUP050446627 PAGE 583 MAY 1985 Hi :!5 .a irt to W CcMo s CM CinM m O' tino COM' CO Wo &oi *au9 ooa SO * O O CM <0*> <0> inm. CM W .H >h a J--*< VIU- li M OoILK u*. * . U. uiui fzc- I 3WZ I< cm cl a ofel W2 >- Z(0 OD: hMUQJ Xu UMX (D5Oh$ SPn HASKELL LABORATORY CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT Krrs*. i<c DUP050446628 PAGE 589 UJ MAY 1985 HASKELL LABORATORY - ro o* :g :5 i iu ck CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT EL X UJ r*t 1A K* % K> Ifbt r4 Oos I O' OU 2 O 5 CK K UJ > o to to ba*-> o DUP050446629 PAGE 578 * UI * <ot ip N CM sr 10 s B E g< iH O * tx au CtoM It) O' o o 0* to O' O' o Nt to rH -0 ? H H to O' O CM lft CM to CM CO rH O' to *> 6 sO H N o CM CM O N O' O' m to 10* M) CO H m> CM sO CM CO pH CM to CM 8 O' O' * * to 't c0 0 CM LA O* to APRIL 1985 HASKELL LABORATORY UJ *5 a D *H N CM Sf CM O' CO 10 o M5 N rH o iH o s CM O' tv CM O' CO H- to tv k O' e (jy CO o CM 0* ->0 sCt o CM CM H >0 CO to N oO I _ PS <C h--I < -J Si Hg, u. s K . u. UuJi zH ! =f3z wH E W U- Q OOP M > V) H UI EHO X <J OgxHPS DOM LA J- 3 <h a N O E O' o O' ** 1100 < 2 c* O O' vO LA Hi M tv tO H m CM -a* N rH O* oo o oo o O'O *o i CM CM LA If) tO IO CM LA tO ui u z LLl X UJ uU.I X eO o CM to O' O' O' CM CM CM LA LA LA to to IO H S -J XX UJ g s IUzi UI 5Q. trX tf) U) UJ UJ IS V) gg XX CJ u >* nV H w tn lUaI X 5 o 3 g i 3 3 5 UJ h* u X o 3 S 1 p < UJ X X UJ > o V) UI H JH 5 .j mJ < LA (0 UI -1 UI > LU 1 J < to to UJ X < 5 X u UI H tA UJ K u UJ If) tf) UI u H > s H > 3 J < LA 1 U < (A X o UI H 1 u o < UI X X UJ > M > Ui u >x 3 < V) >X 3 < (A X a UJ H UXI HO UI CO ia IS 3 to EI S x(A 3 LU M (A w 5 U H la LU 6 u M LA UJ 5 U M to UI ( D o LA J X if) X u UI UJ LA > X (A X o UJ o >g o < t > to o -J o B <c 1 >g o B < a o < 3 < < < K 1" a a DUP050446630 CENTRAL RESEARCH 4 DEVELOPMENT DEPARTMENT CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT HASKELL LABORATORY APRIL 1985 PAGE 579 eI CO HH SOU K CO WO 22 ~ U_ *8 3hZ \< CO CL g W U- o 2uW o > oc OhU DC Hi O XO UHI SX H WO HHS S o oo r*H to 8 e E O s g in 13 I DUP050446631 PAGE 565 ro ift O' e S ro <r A8 o 8 :S a *o t- N CJ <! W to Ut o sO O' v0 O' (ft *0 O' vO Kl O' o N CJ *0* IO ri vD *$ r-t <0 sr u? rt O 't cO Cvt to iH K <X <0 H O' K> s? **0 H r* o CJ CJ CJ o iC O' |0 N Kk lA CJ f-t CJ tO 10 in <0 CJ o to t o 10 H H 8 < S c !E UJ a: a 3 U '1O0 Ol *-*06 <0 *<403 CJ O *J MARCH 1985 HASKELL LABORATORY CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT PS 3$ <3-zj MK -- oU. u~# i , u. Ul h- t UJ Z 3HZ < w 3CJ CL fl u. o ow o or z >- to OhUl OS M Q 88x ggt to H Z >0 h Z 3 O lfl X CJ < N I**. Q to UJ HO NM QS UJ -3 | O K a. tr 2< lfl to 1u<A0i It(An0 OM' 1-4 JO |h0- w-d- O' o<0 Oo' 0 ss z3 eQg > o 0UJ (0 z Ul 0L XUJ Ik o (H0 z Ul x UJ UJ a UJ (0 < X u eg (0 2 M Z < 0) UJ a: < X u X ut H 3 CL X o u J1l UJ X (O < X to UJ atxt < X o Ul OS Hai <o UJ X X UJ > o X H < a. j UJ wl J < to X h< CL -J - 3 < to X u Ul H X 1< a. -j o to z o a > Kto 9 UJ M LL ><Dt J < (0 i to z o o > a: to 9 LU M U. Hi Hi P < Ul ` >UJ X J X Ul mJ > o < to to to UJ UJ MH s H to to UJ f3oc: 12 3 o << Hi LI uj U>J .J < to to UJ H to LU H3 u < >a 3 < to X u UJ h10 UJ H to Ul H3 u < m Hi u UJ .> UJ to to UJ < o (0 Hi >1 tt UJ a to Ul to -J <> o D Hi to z X o UJ X u UJ t- t- -1 < to X oUJ H* 1 o UJ to > a to x uUJ - P< UJ xQS LU > o >o o H< HI Hi > UJ >< < to | > Zoj o X H!<a. >- < < to X oUJ H> | Htf-l oZj o X p Q. ? o o UJ H < -J Ul K g X o p< UJ z UJ It XUJ -J < 5 H to 'lffl 0 o tE Uu_J < rv J-- & U"J) 3OQ to o eg a. DUP050446632 CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT HASKELL LABORATORY MARCH 1985 PAGE 566 Stf H 33 Si H Of O U. --2 U_ Ik3 Ul I- I uj Z 3H2 I< Mao; w3 uoo >- w Or 1U xx oh o OMX 03 X h oOH 07H3 <o ou PiS ;E : UJ X : gu `< >Q :p Ou S! v3- inI <ino 0 '' O3af UJ * < O' Q S03 Of o S1- X :g otil a=>: o10 o X UJ 'X 111 u. UJ Of 40 z slftl- sf H Cvl Sf O Xa. #* PROJECT IS SUBJECT TO 5/.4 OVERRUN LIMITATION wr"> O' p oo So o u. c k DUP050446633 tlfot O' UJ : Sa to o toK> O o* tn o* 0s *Jt* \0 o W yt N rt H S U> <0 sO >-( N O NO' O' tho* in in to sj to r-t Sf O' O' to CM to cf o in in H PAGE 596 FEBRUARY 1985 HASKELL LABORATORY 5 o fCM 'd* to to in o 9O0' M3 r*4 N H M3 H M> o CM $<0 to CO CM <9* sO vO CM O CM IOf)* iO-l' <CMr 3 i" 5 15 s H DC O U- * * U. e* 5* u. UUJi hz* I ?sz u. o uoo HX Z >- <0 O h UJ DC H Q XU UHX SX H OM CO t- 3 o H 'O o to X CM N- < Nto Q UJ M HH O UJ XO 2o X X< :S CO XO 3 IO *o <0to CtoO Ho W IT) CO u X3 z 10 D CM oto zU UJ X M >CO X H >MX w M M H su (2) X <t UJ LU > LU 3 < CO a < IU X >* X 0 < UJ H > UJ -J LU > UJ < < CO H u> UJ UJ co _J .J < to >- X >XN UJ -J 3 o in op h(J- UI lO z UJ X X lu u. o to zt UJ UJ .J tu OUJ CO < X O B x tmoj <sH z < X u X LU [X X auX j UJ X CO < X CO UJ CO X < X CJ h o UJ X H 0 X X UJ > o 5H < 0. J < oM Hz J o mJ -J < 10 1 <Xc --J < o wz M _J u X u UJ 1- tE < X J < uKzM U X LU > o CzO o u > X (0 n~j UJ W u < J < CO CzO o u > X CO 0 J UJ M X X X UJ > o to UJ n o g (0 UJ t3L) < .J wJ < CO to UJ H 0 3P (0 UJ H3 U < J .J < CO CO LU HQ p CO UJ H 3U < X u UJ 1- to UJ w Q PP CO LU b3u (0 UJ o H > X UJ to -1 X CO Xu LU h- 5 UJ H 1 Utu 10 > X to x u LU 1- o < UJ X X UJ > o >C9 O.J O < X >X < J < to 1 V ID o _J o JE < X <c to X(J UJ t- 1 >* CD O o <Xt~ X D LU } 3 LU X ctt Ko 3 3 LU CzO UJ Xx UI ~<J p o p to o 'i* in _j to oJ- X LU u. to z4( p UJ CQ 5 CO to IH p o U--Jj otc x DUP050446634 CENTRAL RESEARCH S DEVELOPMENT DEPARTMENT CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT HASKELL LABORATORY FEBRUARY 1985 PAGE 547 * UJ :5oc Ho H ui 53 H CK O 1L <- u. ^LU H* LIU LU Z 3 HZ 1 <C MQ.K W IX. o as KHQ Xo OWI SwXohsHw * H< vO * Q o* *P H rsot* g MZ Q O D. tn X <\l O to ck a. to o. win Oth' E z o zsa: g u5 a 3 DUP050446635 1A O' *G *0 O AS PAGE 529 JANUARY 1985 HASKELL LABORATORY s HS S< ~tJ sH sOt O U. -- U_ *8 . LU Ui t UJ 2T 3I W< Z c j a. n wu.i ss z > to O t- LU EXE Hu a to X ^ 3 5 o :R N CJ fot rife ID O O'10 o a*10 gD 2O'10 O* N pH i-t OH o S<sf N CVJ <0 to <0 O' o O' <0 o (M g? o M eg go K> go eg H in otft R * UI :5 *5 BO "* sO * CL :SU sHoI o o oo o o o o K1 o oto g5 g? eg eg 10 10 h i to o eg ift to eg <g ift HI g m in eg eg eg in IO in HI in in z H> rH h. SH3- I<ft0 O' to to itno UI fefe I g g s s ^Z Jz<Hs to to tid<du: btsi q<: 55 a. a. gu gu 1^U ^Ui C<iO it<O to 111 to Q<IUL ui a. s to X< to bi to u 0<i1n g 0 1 -UiuJJ _i to X u >K> < <(0 CL <L> Z M mu) o < iu X CL UJ > o to Z uP > D to a Ui M u. >k < -J < to 1 to z o u > cr to o Ui X Qt UI > o to UI H H to 3(<J M H > UJ J -J < (0 <0 Ui w s to 3Ja<- w .J UJ > UI .J < to to Ui M hto fe >* OL < _I < to I u UJ Ito UJ w H-* to 5 H U UJ (0 to Ui U w > K UJ to _i <c u H W > UI < to 1 u UJ to > K IuoI-i < to Iu HUI >I to IuHui O< Uzgi s 3OX < o. > UJ >a- 3 3 5 3 O > CO 5 >CD 2 3 UtcJ tt PROJECT* * IS SUBJECT TO 57. OVERRUN LIMITATION DU P050446636 CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT PASE 530 JANUARY 1985 <o oosi 's- IA sr o * * O< SO H O' o s 3 st *0? CO CO CO CO ui :S I6 p^ *B O' KI m LU U s sor S CJ r> s hro* UJ HASKELL LABORATORY CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT N N JO Oa cu J sr UJ if) CL. UJ X (0 UJ z o r-f UJ <r 0u. 0. o JO XHH UI 1 tt -I UJ < la. UJ h- to oz H H* < LA ro ## PROJECT IS SUBJECT TO 5'/. OVERRUN LIMITATION JO If) O' rt us JO oa DUP050446637 PAGE 986 DECEMBER 198A HASKELL LABORATORY Z o ih a H UJ <3 X9 zz IH eg O lb ** lb *9 X u. UJ H i iu Z 3 >H Z I< cj a g u. a oo H ZVW O H UJ KHQ XU U HX ZP Ho HZ riCNKn*oJ.l hULU* 3z<o: oUNWOOJJf "> X OH aa 3 < bi <o NM Cf O- to oo 2x o& ig * UaJ :g U U8 Hz D O *x :5 UJ Of :g U UJ o to o X CJ O' sf 1O--1' o* p-r O in O' in O<oo' CJ O' M O <* <CK0J) r in co iH O' Kl *o CJ H HN Hr. o eg >o S<9' in r%*o. K> eg r* M in CJ tn in os in H <3i> co * H in tn rt oa* h in oCJ e in O' rf F* coCD in Kl Cor*J* Hr*v (O in t H H P Oa s OO a o o o Kl o o o CJ eg toO CJ CJ in in eg in CJ in CJ in in in m m in g CJ Kl M in iion * in h chj- j<~ h Kl H 5 OC UJ CD zUJ CIXUL UozXU6fUc0J~l 3 UJ UCxi<funtDcJ:. 3CL <o < r n Z < O<X1Utun0Jf CIto<XoUoOr oUHcJ OIhU-f 33 Q. CL OO ai ai 33 U_Jj 3IU tnX X in X X<c < tUO<oXtoocJf OUf33ouC1-ZLJf 33UJ X to X< UE<Xo<toK0J Huiu waa: a<IXD>OUUCJ XHa< 3H z M J u IH 3U>U3ll 3<(0 <Xp CL <3wU Z 3 3 U O<3>(e0C-f XoUHl XH< a. w3O< Z w3 U U>Q<XDUoCJJ tUoHJ a 3H* CO UJ 5u <t HH >I3U w 3I>U3UJ 3HtoC 3*(0 tIIHUo <wU0J to to Ul. IU u u << u<><3toXuIKU wtIQ3hUo" CO US CJ < HuUtoJ tUoJ >uwOUtoJf <o3wc zX(UJJ H wM >I3U <t3o uUtoJ >O(Of XuUJ H 3<to XuI1UoUtoJ >Xto X u IU H- o<UXXU>JJ o >oto- 3 oX K* < a. HH >I3U K> 3<to 1 Vtoo 3 oX -- a< >(<3<0 XoIhU 1 >oo- 3 o p < a. \Xo oIhU5t3IUd *9 oK< 3 UJ 8IU axUJ. 3< H HO imo<n1 3 CD Jo-~ K3ltbo z< a K in oP yhUf5tofoJl w(0 {U"oJ J) X a. Mr * CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT DUP050446638 CENTRAL RESEARCH 8 DEVELOPMENT DEPARTMENT HASKELL LABORATORY DECEMBER 1984 PAGE 987 > <0 in ou X oz <* so i ' 0 oe* :p i H H0 -d* O z <r o LO X <\J IV o 10 UJ N } -- JH ou DC ILi E-*> o q; 3 Ol < ItUo z UJ CL X UJ f-4 JL O H <0 z UJ s IH UJ J Ifol UJ 1*. PROJECT* * IS SUBJECT TO S'/. OVERRUN LIMITATION DUP050446639 teHz-g UOaH)' DCCL <S0' h*et0> ouu< a<au*3 1 tUtoaaaPooJi PAGE 981 NOVEMBER 1984 HASKELL LABORATORY (ouft < pp OLft OIft O(ft NCO CO fO tO CJ M to O z0H<-<HI omI<-JMXz 7zOoi u. --XuW21*i LHH<ZL ZU_l. *J CL g W LU O yg KHQ SSx in gi-fac or*Hc 2 41CrNt*of*J.t bo~ HQfIt 5sot O' HUNJt DOXtC DC z> a. < ** Ho< ** oh- CvvrJ CoO CJ MZ CO* zO *** DzLUC CO*O' o O' rco- CJ m to <0 O' O' oCO ok CJ *3* to O' h oCJ pH pH O' o to *0 *o w to <U o OI'-' Lft o oh* N I". *CJ0Mft 0C(fJt *C1ofJt to to to *tft M KCVJ h< rto* ixM- 1 gHi UzCuXUXOJI uo. CO UrUJJ m3 KU U<XtoCDOSjJt ZX5 XC.n<JO z < CU1D<XuOC9I CUD(<Xu9OCJ DUHC-I Dut-Ci m_gXouUXto1)Ji gX~.UXootJo1JJ <X <X <UXXo<u0J X UJ hbr -X-CooJIJL UxtoJ <X <LCXU09 5 Hu HUXaJ f<UXDu>Citi p<a .j zOHH< oJ H >-UU-1JJJ m<COi p<0. uMzt<H mui >tt3<(0 XuHUJ P<CL U_<zMl M moi D<XUXUJJ >o CO hUwoX0J UI fe u < WH >UmJJ m<COi CUMOJ w UJ o < H _J U>UmJJJ m-C5Oi 1UHXJto--o0J UJ so < >X2 <10 XuuUJ CO UI tH CO u 5 u < hoU(0J tUuHoJ XUcoJ J uMzX< oUJ H HW u> <10 1 oUtoJ >Xto X uJU-J <CO XUhCJJ1 CUCOJJ Dt>oC X o UJ H oX<oUXU>JJ >1o9-oJ p <CL HH >UmJi V<X <to 1 V1O9 Xo t- <a. >- 5 <(0 Xu HUJ 1 >mO(o9JP <CL Xs: o QUH<XUJ*II tl Xo J<S mi Ui gUCxULJJ _<HO> t-- to<Lofpt o otUuzoCOc.i J<X-- s Ju-- DUP050446640 CENTRAL RESEARCH DEVELOPMENT DEPARTMENT CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT HASKELL LABORATORY NOVEMBER 1984 PAGE 982 z ow S!2 azc D jc IH OS o b. -- U_ i Uu UJ H I 3HZ uou. oo Sm >- zw - ui HO 5"Ki SSt; tfihS at I5 0 f8 0 Is oz <;g H z ** atxt : O * <o h ifi O U MZ CQ O Z I 'O UI :5 O) OS o Z h* O *E OS O' N. H O N N K> hN M U OS U-o> 0 1 UI to Z UJ ax m ui X in O' oz DL o uu CO < a* 0r*f 1 oo: o (J # * PROJECT IS SUBJECT TO 5Z OVERRUN LIMITATION DUP050446641 PAGE 973 Iu Q ip a* (VI if O h ' H, M <0 <VJ (0 (vl O' o Kl SO H LA (Vl O' H sr (0 CM M N LA CO H O to *0 H r* o (vl rH *o Is. to LA H o CO c0 o j o (vl 3 (Vl 3 H |C <? <0 r-i CO o |C H sr sr H O' H rH <0 O' M 1A O a LA to *\ iH rH LA IA tA 8 P E QKOQ1 OCTOBER 1984 HASKELL LABORATORY WH3 I O o oHA Nw E r<*o. <Ct r(OH H (vi 0 N <o (M s sr A* sf o (0 IA o N CO * o IA LA sr IS co IA N NN rH H rH H H rH ST CO o * (0 o CJ C4 CO sr Mcs O o o rH to *> CO IA IA O to LA oo oo ij) vo vi <st ssu? o o <tf 8 o CwO ltoa in in W UJ tSo i5d?c sto g (<0 i u CL UawoJ s > R (Q3 o 1 o s eg g H HUJ UJ CL CL sH 8r<*vl R a s o 10 B X Ho* Ui UI 3 IE B wl a DUP050446642 CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT Charles River Breeding Laboratories, Inc, 251 BALLARDVALE STREET, WILMINGTON, IMA 01887 AREA CODE 617 TEL. 658-6000 CABLE ADDRESS: CHARIVER-I30ST0N 0 TELEX: 94-7433 From the hand of the veterinarian to research. Remit Payment to: P.O. Box 3869, Boston, MA 02241 t o? G7475-C3 1 CLiPGNT OSNfcfcCUftS CC h as k el l l aec r at c r ies ACCOUNTS PAYABLE NEWARK DELAWARE 19711. `EJ? 074?5-047 6.1* DUPONT DSNErOUft 3 HASKELL L AtrCR ATCRILS NSKARK* CELAteAK? CC. -I; DATE SHIPPED CHARLES RIVER DIVISION INVOICE DATE TNI.UK _ NO fi/C 6/S4 SITNfcRtLufc 8/Q6/S4 YOUR ORDER NUMBER LLCX4CI2 RELEASE NO. HJl OUR ORDER NO. Ic3 9 5 14 SHIPPED VIA ?-1 - 'r c STRAIN/ITEM CC GRAM RANGE iTc-rso DAYS OLD SPECIAL SERVICE SHIPMENT REF. NO. 3 84 2*3 62 SPECIE a a* s SURGICAL PROCEDURE SURGICAL PROCEDURE QUANTITY SEX 60 K 16 HOLD POST OP CRATES TYPE NO. r 1LI 6 UNIT PRICE ^ A ?; AMOUNT *. k. ' * *J ' SURCHARGE C BOX FILTER 38.CC SURGERY *CV FREIGHT 51.61 TAX ^ OTHER A T B 0 f ei-'Td i.6/1 T'Alfyu'aTEM J" *2* i i \ j ! ! DUP050446643 N 30811.02 PAGE 959 SEPTEMBER 1984 *O KN> CM ooN ' <cinmo O' s ihd** rv SO O* o <r <o to N 1O0' *0 to rO*.' oco 4* oe n isd0* ini Oco' r** CM trov trov Si* CM CM O' St* O' 8 sO to |IVv o o CO O' 4* to to CO m o* o O' 4* CM Sf CM tToV 0 <0 to O' to O' to O' in O' Sf i0 to #> O' H CM H <0 O' O' CM CM N C-dM* *r> N CM O' O*0' CO to O' m M(03 eoo HASKELL LABORATORY CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT zoM O H UJ 35 < -J ii W CK o u. m^ |Llb 1 ?5Z 1 UI o rv CM R Sf CM |v CM o <o rH O' s0 m3 O' 1in0 oo CO CM N tft a1 X o s 4 4 M3 CKin<J CmmM mCinM itCnoM <CsO* (d0* CM CM CM CM 3 min s to NH CM m O' CM tn to O' CimnM ro imn osNf |V St* 40* m d* 4o* d* 4Osi*r oo O to o IO iH to CM to CIOVJ 3 3 in to CNM rv 4O* WJo to e <10 (0 CO BU UJ to to 33 UI CO 3 3tof hi (0 55 5 0) sz UI a. XUI O UJ CO < X u X 0 ui iu bb txo. a a UJ s a UoJ g I to u. z r z o oo o 2 5. u u o s to li li -1 -J -1 .J J <ujc 3 Ui < UI IU UI E UJ a Ui r t- z < XX CO to << XX X 10 < X s u 3O < H_ >> < & > HI X DC UI > UJ 1U (!) -J -* . X <0 .1 J U UI < < IU o _S 3 t- O< UI <(0 X O <0 10 t- H *0 tO CO CO I sa Sf *"Hi H ui H ui H lu ui H V) a U0I o i CO CO > > 1 g .03 g 2o 1i X a g a I s US o UI EL g CHO X UUI < to 3 d: RR DU P050446644 N 30811.03 CENTRAL RESEARCH & DEVELOPMENT DEPARTMENT HASKELL LABORATORY AUGUST 1984 DUP050446645 * * PROJECT IS SUBJECT TO 5X OVERRUN LIMITATION CENTRAL RESEARCH AND DEVELOPMENT DEPARTMENT HASKELL LABORATORY FOR TOXICOLOGY AND INDUSTRIAL MEDICINE DATE: July 31, 1984 TO* F F SWATN JR FINISHES & FABRICATED PRODUCTS DEPT B-5204 PROJECT MR - 7254 PART II TITLE: SUBCHRONIC (2-WEEK) INHALATION TOXICITY OF PAINT FORMULATED WITH DESMODUR N Authority is requested to undertake the study identified above and de scribed as follows: The subchronic inhalation toxicity of Imron paint formulated with Desmodur N will be studied under Part I of this project. The purpose of Part II is to cover the additional cost of analyzing chamber samples specifically for Des N content. Six samples/exposure group/day will be collected and analyzed by liquid chromatography during the 10-day subchronic exposure period. CFR etl UD INFO m LFP Amount requested: Forecast month and year: $8,000 Experiment to start: 8/84 Previously authorized: $53,000 Expended through: $ -0- (date) General Ledger & Sub-Account to be charged fSty-fti. 7394- Experiment to end: Final report to issue: 9/84 & 6 mo. in pathology 5/85 Request for study made by: E. E. Swain CLASSIFIED: R&D ___ OTHER ___ (check appropriate classification) If this request meets with your approval, please enter the GENERAL LEDGER & SUB-ACCOUNT TO BE CHARGED and the CLASSIFICATION, have the original authorized and return to HASKELL LABORATORY, CONTROL SECTION. The additional copies may be retained for your information and distribution. Proposed by Qa j ./'.c, fl. Laura A. Kinney Approved by j&kvJU c Gerald L. Kennedy (itLJLAuthorized ___ g/7/W O (date) DU P050446646 N 30811.04 CENTRAL RESEARCH AND DEVELOPMENT DEPARTMENT HASKELL LABORATORY FOR TOXICOLOGY AND INDUSTRIAL MEDICINE Tfl* F F SUAIN J8 FINISHES & FABRICATED PRODUCTS DEPT. 8-5204 DATE: July 31, 1984 SUi uo INFO MDK LFP PROJECT MR - 7254 PART II TITLE: SUBCHRONIC (2-WEEK) INHALATION TOXICITY OF PAINT FORMULATED WITH DESMODUR N Authority is requested to undertake the study identified above and de scribed as follows: The subchronic inhalation toxicity of Imron paint formulated with Desmodur N will be studied under Part I of this project. The purpose of Part II is to cover the additional cost of analyzing chamber samples specifically for Des N content. Six samples/exposure group/day will be collected and analyzed by liquid chromatography during the 10-day subchronic exposure period. Amount requested: $ 8,000 Forecast month and year: Experiment to start: 8/84 Previously authorized: $53,000 Expended through: $ -0- (date) General Ledger & Sub-Account to be charged Experiment to end: Final report to issue: 9/84 & 6 mo. in pathology 5/85 Request for study made by: E. E.Swain CLASSIFIED: RAD OTHER (check appropriate classification) If this request meets with your approval, please enter the GENERAL LEDGER & SUB-ACCOUNT TO BE CHARGED and the CLASSIFICATION, have the original authorized and return to HASKELL LABORATORY, CONTROL SECTION. The additional copies may be retained for your information and distribution. Proposed by CLiN-L*" 'l Laura A. Kinney 7 \'tnsfaApproved by _j^a.Jul.tf, Gerald oedy Authorized (date) DUP050446647 CENTRAL RESEARCH AND DEVELOPMENT DEPARTMENT HASKELL LABORATORY FOR TOXICOLOGY AND INDUSTRIAL MEDICINE DATE: May 8, 1984 TO: E. E. SWAIN, OR. FINISHES & FABRICATED PRODUCTS DEPT. B-5204 PROJECT MR - 7254 PART I TITLE: SUBCHRONIC (2-WEEK) INHALATION TOXICITY OF PAINT FORMULATED WITH DESMODURN CFB JOt*e Lj d J/4F0 m&k Authority is requested to undertake the study identified above and de scribed as follows: i The subchromic inhalation toxicity of DesmodurN will be investigated in Medical Research Project MR-7253. In medical research project MR-7254, the subchronic inhalation toxicity of a paint formualted with Desmodur*N will be evaluated. A brief outline of the study design includes: t male Crl:CD rats will be exposed; exposures will be 6 hr/d, 5 d/w for 2 w; test groups will include 3 exposure concentrations of paint formulated with DesmodurN; paint without DesmodurN; and an air control; and 0 and 14 days post exposure evaluations of hematology, urinalysis, and pathology. Forecast month and year: Amount requested: $ 53,000 Experiment to start: within 3 mo. of receipt Previously authorized: $ -0- Experiment to end: 1 month after start Expended through: $ -0- Final report to issue: 1 yr. from end (date) General Ledger & Sub-Account to be Request for study made by: E. E. Swain charged "7 33"/- CLASSIFIED: R&D ___ OTHER ___ (check appropriate classification) If this request meets with your approval, please enter the GENERAL LEDGER & SUB-ACCOUNT TO BE CHARGED and the CLASSIFICATION, have the original authorized and return to HASKELL LABORATORY, CONTROL SECTION. The additional N 30811.05