Document 9J0nBgavDozqJzw8px6wdvJkq

May 16, 2974 Mr. F. A. G. Collot d* Escury Akso Zout Chemle Nederland B.V. Postbus 25 HengeLo (0) Boortorenveg 20, The Netherlands Deer Frits: The MCA sponsored study on mice has shown that angiosarcoma did develop at all exposure levels: 2500 ppm, 250 ppm, and 50 ppm. The exposure period was 7 hours per day, 5 days per veek and 7 months had elapsed vhen the first results were obtained. Needless to say, this Information created quite a stir. The emergency temporary standard was not changed by OSHA from 50 ppm to 10 ppm; that was Just one of many rumors. Instead, on May 10, 1974, the Federal Register contained the proposed permanent standard by OSHA and it effectively states "aero" exposure levels; otherwise protective cloth ing and fresh air breathing equipment will be required. I have enclosed a copy for you. There have been no announced reactions to the proposed standard. Conoco is beginning to formulate its strategy regarding the standard. Maltonl announced during a 1H day sesdnar in New York City, sponsored by The New York Acedemy of Sciences and The American Cancer Institute, that ha had observed one angiosarcoma in his initial rat study at 50 ppm, exposed 4 hours per day, 5 days par veek for 52 weeks. Ha hastened to caution the rat vss vary old and the observation may not be meaningful. Maltonl has net seen significant angiosarcoma in his mica studies at 50 ppm, 4 hours par day, 5 days par weak for 41 weeks. Please note the difference in exposure times per Maltonl and MCA. One other note. There are apparently 13 documented anglosereoma cases in the United Staten and 6 in Europe (2 in West Germany, 2 in Sweden, 1 each in Norway and the U.K.). Your# vary truly. 3C3 CS cs; Si*5.3 r~-i ; <55 O' 03 *51 1m anc /.. -