Document 9GeVadVVvor4Z9yOZ5ga9Rj5

INDUSTRIES To: MEMO FOR THE RECORD INTER-OFFICE CORRESPONDENCE Date: December 17, 1976 Z. G. Bell, Jr. Location: 10 West Subject: Telephone Conversation with Dr. T. Torkelson, Dow In a conversation with Dr. Torkelson of Dow Chemical held on December 16, he provided me with the names of people within his company who are knowledgeable on various health topics. He suggested I discuss chromosomal aberrations with Dr. Kilian (Freeport, Texas, Telephone: 713/238-3361). Dr. Kilian is performing research on the chromosomes of their employees. Ted was not aware whether the data collected was being used to exclude workers from vinyl chloride exposures. He doubted it since they have not gotten a data base on the normal number of aberrations for a non-exposed population. Their work is with lymphocytes because of their availability. Usually 5jul of blood is required. The cost, he believes, is somewhere around $100 per employee. The second subject dealt with the person most knowledgeable concerning removal and return of workers with abnormal liver enzyme results. Ted suggested I talk to Dr. John Venable who is also located in Freeport, Texas (Telephone: 713/238-3591). Dow's industrial hygienist at Freeport is Roger Daniel at 713/238-2121. Dow is doing some testing using the sheep cell rosette procedure. This was discussed by a physician from Houston in a cancer seminar held last spring. Discussions' were held on vinyl chloride studies beirig performed by Professor Maltoni. The closest thing to acute exposures with long-term latency period was test BT^q. In this work, C x T equivalents were investigated; that is, groups of animals are exposed as follows. A. 4-hour exposure five days per week for 5 weeks B. 4-hour exposure one day per week for 25 weeks C. 1-hour exposure four days per week for 25 weeks While Professor Maltoni has 12 to 14 studies in progress, only his BTi results have been published. Zeb G. Bel 1, Jr. ZGB:mal cc: F. C. Dehn H. B. Lovejoy, M.D. A orw A. i . SL 027978