Document 99p0xnjrj11NoB7r8EgaYVqN5

BACK TO MAIN 3M FLUOROCHEMICAL SUBMISSION TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE Click on Study Title to View Report Multiple Chemicals 1. "Inter-Species Comparison of Mechanisms Fluorochemical Toxicity following Intraperitoneal dosing of perfluorooctanesulfonate (PFOS, T-6295) or ammonium perfluorooctanoate (APFO, T-6889) in Rats and Guinea Pigs and oral dosing of N-Ethyl perfluorooctanesulfonamido ethanol (N-EtFOSE, T-6316) in Rats," 3M Medical Department Corporate Toxicology, DT15-A, May 24, 2004. 2. Molecular Biology Study: a. Final Report, "Comparative Molecular Biology of Perfluorooctanesulfonate (PFOS, T6295), N-Ethyl perfluorooctanesulfonamido ethanol (N-EtFOSE, T-6316), N-Ethyl perfluorooctanesulfonamide (N-EtFOSA, T-6868), Perfluorooctanesulfonamido acetate (f OSAA, T-7071), and/or Perfluorooctanesulfonamide (FOSA, T-7132) of in [sic] Rats and Guinea Pigs following Oral dosing," 3M Medical Department Corporate Toxicology, DT-15-B, May 25, 2004. b. Amendment to Final Report, "Comparative Molecular Biology of Perfluorooctanesulfon ate (PFOS, T-6295), N-Ethyl perfluorooctanesulfonamido ethanol (N-EtFOSE, T-6316), N-Ethyl perfluorooctanesulfonamide (N-EtFOSA, T-6868), Perfluorooctanesulfonamido acetate (FOSAA, T-7071), and/or Perfluorooctanesulfonamide (FOSA, T-7132) of in [sic] Rats and Guinea Pigs following Oral dosing," 3M Medical Department Corporate Toxicology, DT-15-B, July 16, 2004 (revising page 59). 3. Cell Proliferation Study: a. Final Report (except for in-life appendix), "Cell Proliferation Study with N-Ethyl Perfluorooctanesulfonamido Ethanol (N-EtFOSE; 3M T-6316.11), Perfluorooctane Sulfonic Acid Potassium Salt (PFOS; 3M T-6295.16), and N-Ethyl Perfluorooctansulfonamide (N-EtFOSA; 3M T-7091.1) in Rats," Charles River Laboratories, TRC 1132-100, August 9, 2000 (amended November 8, 2004). b. In-Life Appendix, "Cell Proliferation Study with N-Ethyl Perfluorooctanesulfonamido Ethanol (N-EtFOSE; 3M T-6316.11), Perfluorooctane Sulfonic Acid Potassium Salt (PFOS; 3M T-6295.16), and N-Ethyl Perfluorooctansulfonamide (PFOSA; 3M T-7091.1) in Rats," Therlmmune Research Corporation, TRC 1132-100, May 2, 2000 (Appendix 1 to full report). 4. "Evaluation of the Northwest Bioanalytical Method Validation Reports for PFOS and Related Analytes in Human Serum or Plasma in Meeting the Requirements of the FDA Bioanalytical Method Validation," Quality Associates, Inc., QAI 405-503, December 31, 2001.