Document 99n9zKywgB8avXbz82L2dxQ76

X INTERIM RESU) VS OF EXPOSURE OF RATS, HAMSTERS AND MICE TO VINYL CHLORIDE M. L. J. w. D. E. and J. C. Keplingcr, Ph.D * / Goode, Ph.D., Gordon, D.V.M., Ph.D. Calandra, M.D., Ph.D. Industrial Bio-Test Laboratories, Inc. Northbrook, Illinois The following data are partial results of a study in progress at the Industrial Bio-Test Laboratories, Inc. The studies art being coordinated for sponsoring companies by the Manufacture Chemists Association. The data are very incomplete but becair of their significance were first presented to EPA, NIOSH and OSHA on April It, 1974. In this study which was designed to complement Maltoni's studies, 100 rats, hamsters and mice of each sex (600 total per exposure group) are being exposed to either 0, 2500, 200 or 50 ppm vinyl chloride vapor 7 hours per day 5 days per week. Mice will be exposed for 9 months and kept for an additional 9 months. Rats and hamsters will be exposed for 12 months and kept for an additional 12 months. The rats are COES Charles River; mice are CDI Swiss Charles River; and the hamsters are Golden Syrian from the same source. Food is removed during exposure, water is present and no bedding is used at any time. Moribund and dead animals (when possible) receive gross autopsies and are photographed. The major organs of all animals are fixed for histological examination. Only the tissues from a few animals have been examined so far. The table shows the results to date (about 8 months exposure). UCC 083308 INTERIM SUMMARY OF TUMORS IN MICE EXPOSED TO VINYL CHLORIDE FOR EIGHT MONTHS EXPOSURE -GROUP CONTROL NUMBER OF ALVEOLCGENIC MORTALITIES ADENOMAS, ______WITH NEOPLASMS___ LL'NG._ TOTAL MALE FEMALE 0 (7) (2) 0 Location and Type of Tumor ANGIOSARCOMA, LIVER ADENO SQUAMOUS CARCINOMA, MAMMARY 00 50 ppm 4 13 2 2 2 200 ppm * 15 3 12 12 11 3 2500 ppm** 30 6 24 23 28 6 MAMMARY, WITH METASTASIS TO LUNGS o, 2 1 1 U C C 083309 * 7 MALE AND 2 FEMALES CONTROL MICE HAVE BEEN EXAMINED HISTOLOGICALLY. NONE HAD TUMORS IN LIVER, KIDNEYS, HEARTS OR LUNGSi ** Only mice with tumors have been examined histogogically. Mice were exposed 7 hours/day, 5 days/week. Preliminary Findings from MCA Administered Study at Industrial Bio-Test laboratory April, 1974