Document 99ZzO0Y9VqBXRm8NMv524KkYL

TOXICOLOGY ENVIRONMENTAL SCIENCE! CHCM I STRY PLANT SCIENCE# M E0ICAL SCIENCE* 3rtduAfruoi BI O - T E S T laJmaivwid', 3m 1010 FRONTAGE ROAD NORTHBROOK. ILLINOIS 60062 June 17, 1974 I, TCI CPHONt > 7 V Dr. Harry Heiman Environmental Science Laboratory Mt. Sinai School of Medicine Mt. Sinai Hospital 100 Street and 5th Avenue New York, New York 10029 Dear Dr. Heiman: Enclosed is the summary paper presented at the meeting of the New York Academy of Sciences on May 10, 1974. Also enclosed are 2 copies of the copyright form. If there are any questions, please call me. Sincerely yours MLK/kjl Enclosures cc: Dr. K. Johnson | Dr. T. R. Torkelson M. L. Keplinger, Ph. D, Manager, Toxicology SL 074151 INTERIM RESULTS OF EXPOSURE OF RATS, HAMSTERS AND MICE TO VINYL CHLORIDE M. l. J. W. D. E. and J. C. Keplinger, Ph.D., Goode, Ph.D., Gordon, D.V.M., Ph.D. Calandra, M.D., Ph.D. Industrial Bio-Test Laboratories, Inc. Northbrook, Illinois The following data are partial results of a study in progress at the Industrial Bio-Test Laboratories, Inc. The studies are being coordinated for sponsoring companies by the Manufacturing Chemists Association. The data are very incomplete but because of their significance were first presented to EPA, NIOSH and OSHA on April 15, 1974. In this study which was designed to complement Maltoni's studies, 100 rats, hamsters and mice of each sex (600 totalexposure group) are being exposed to either 0, 2500, 200 or 50 ppm vinyl chloride vapor 7 hours per day 5 days per week. Mice will be exposed for 9 months and kept for an additional 9 months. Rats and hamsters will be exposed for 12 months and kept for an additional 12 months. The rats are COBS Charles River; mice are CDI Swiss Charles River; and the hamsters are Golden Syrian from the same source. Food is removed during exposure, water is present and no bedding is used at any time. Moribund and dead animals (when possible) receive gross autopsies and are photographed. The major organs of all animals are fixed for histological examination. Only the tissues from a few animals have been examined so far. The table shows the results to date (about 8 months exposure). SL 074152 f' Note that no direct numerical comparisons can be made with the control groups as they have not been selected in the same way. Only mice with tumors have been examined in the exposure groups. No tumors have been observed grossly as yet in any of the control mice. In addition to the tumors in mice a few tumors have been observed in rats and hamsters but because of autolysis the diagnosis at this time must be considered tentative. At this time it appears that angiosarcomas may have been observed in one male hamster and one male rat exposed to 2500 ppm and in one female rat exposed to 200 ppm. No tumors have been observed in rats or hamsters exposed to 50 ppm but one male control was found to have a dermal fibroma. These tentative data need to be confirmed and will be reported^ in detail when the study is completed. | k SL 074153 INTERIM SUMMARY OF TUMORS IN MICE EXPOSED TO VINYL CHLORIDE FOR EIGHT MONTHS EXPOSURE GROUP CONTROL* 50 PPM** 200 PPM** 2500 PPM** NUMBER OF MORTALITIES WITH NEOPLASMS TYPE AND LOCATION OF TUMOR ALVEOLOGENIC ADENO-SQUAMOUS ADENOMAS, ANGIOSARCOMA, CARCINOMA, Lung LIVER MAMMARY GLAND METASTASIS OF MAMMARY TUMOR TO LUNG TOTAL MALE FEMALE 0 (7) (2) 0 0 0 0 41 3 2 2 2 2 15 3 12 12 11 3 1 30 6 24 26 28 6 1 * 7 Male and 2 females control mice have been examined histologically. None had tumors in spleen, liver, kidneys, heart, or lung. ** Only mice with grossly visible tumors have been examined histologically Mice were exposed 7 hours/day, 5 days/week H&m** Preliminary findings from MCA Administered Study at Industrial Bio-Test Laboratory April, 1974 THE NEW YORK ACADEMY OF SCIENCES CONSENT TO COPYRIGHT Please read the Conditions of Publication belov. Identify your paper by author(s), title, and conference (if applicable). Sign and return the state ment . The Academy will not publish your paper without your consent to the conditions stated. Conditions of Publication 1. Upon submission to The New York Academy of Sciences, the paper here identified shall become the Academy's property and may not be withdrawn with out the specific approval of the Executive Director of the Academy acting under the authority of the Committee on Publication and Awards. In the case of an Academy conference, presentation of the paper in full or by title at the conference shall constitute submission of the paper for publication. * ? The paper here identified must not be published prior to publication by the Academy and must not be republished in whole or in part without the Academy's prior written consent. 3. The Academy shall obtain in its name and hold the copyright on the paper. Title of Paper: Interim Results of Exposure of Rats, Hamsters and Mice to Vinyl Chloride Title of Conference (If Applicable): Working Group Toxicity of Vinyl Chloride Polyvinyl Chloride - May 10 St 11, 1974 I consent to publication of the paper here identified under the conditions M. L. Keplinger Author's Name (Type or Print) June 17, 1974 Date Editorial Department 2 Elat 63rd Street. New York 10021, Phone (212 ) 8384230 Cable NYACSC1 SL 074155