Document 998oryXZ0KEqV31XyyMY0vbb6

fin hi 14--Toxicology Vol. 71. 1969 19621 ILLEGIBLE DOCUMENT J'li iHjinminK amt m.inic iU'prvsnvc |nycl>ii"- ore discussed and tin- Milking sinnl-mlics Intuitu thtm unfed- It is sucxcstcd ili.it I'll may be a i<>\ic tli-tcfitiinuiil in this psycliusis. Tile (ijvu tcit (J)aviii null Aiiik-liiiaii, KNi7) was imM for the nl urinary I ni.iir-olovulmic icni (I) levels in patients anil controls. Result* showed an increasingly significant rise in 1 levels between controls and untreated patients am) patients treated with LiiCOi. Li may interfere with Hb synthesis in a similar way to l*b. 41 references. S. M. Maxwell 80616* Effects of DTPA jdicthylenetriaminepentaacctfc acid] aerosol on lung contamination by lanthanum. Pasquier, Christian; Voisin, Dominique; Thieblemont, Pierre; Perrault, Gerard: Bayard, Jean P. (Dir. Prot. Surete Radiol., C.E.N., I'ontciiay-aux-Roses, Fr.). Commit. Energ. At. |Fr.J, Rapp. 1969, CEA-R-3735, 19 pp. (Fr). nuail. CEA. By use of DTPA aerosol in the treatment of pulmonary contamination by j.a, its effectiveness was detd. as a function of time. Provided that it is administered at an early stage, in the 2 hrs. after expo sure, >60% can be eliminated using lower therapeutic doses than those'prescribed for other methods of administration. Its assocn. with some enzymes did not enhance the therapeutic effect of the chelator. The const, for the passage of the DTPA- La complex from the lung to tbe blood is -^0.018/min., cone* spending to a period of 44 min. A significant nonehelatable fraction, persisting after prolonged action of the DTPA, of the order of 40-43% is observed. DWJF 896171 Feme cyanoferrate(Il); an effective antidote is thallium poisoning. Heydlauf, Horst (lnst^ Strahlenbiol., Kernforschungsxentrum, Karlsruhe, Ger.), Euf. J. Pharmacol. 1969, 6(3), 340-4 (Eng). The influence of orally administered ferric cyanoferrate(fl), (Prussian Blue, PB) on the distribution and excretion of ***Tl was studied in the rat. PB lowered the retention of **71 by inhibition of its absorption and teabeorption from the intestinal tract. The toxicity of TliSOt was decreased by PB. PB is suggested as an antidote in T1 poisoning, V. N. Gupta S9618u Cyclobeximide-lndttccd ultrastructnral changes la the adrenal cortex ot the rat. Dzsinich. Cs.; Seabo, D.; Okras, I. (lost. Exp. Med., Hung. Acad. Sri., Budapest, Hung.). Experientia 1969, 25(8), 835-6 (Eng), Wistar rats of both sexes weighing about 180 g. were used. Conspicuous changes in the ultrastructure of the tone fasciculata cells were observed follow ing decapitation at 60 min. even after tbe lowest (5 mg.) dose. At low-power magnification, compact masses of irregular shape, medium d. and blurred outlines were seen to have accumulated between organelles. In expts. involving both cyeloheximide and ACTH treatment, tt changes were similar, although the cells appeared swollen. Similar observations were made in some cells a> the zona reticularis, but not in tbe ton* glomerulosa. Tbe fim-;ng* suggested a correlation between the substance seen to accm-ulatc among organelles and the increased cholesterol content of the adrenal cortex. Tbe ultrastructural changes were the consequence of an Impairment of tbe enzyme syrtem. P. J. Farisek 39619v Effect of acetone on the level of ketone bediee in the blood and urine of experimental animals of different species. Linyuchcva, L. A.; Tiunov, L. A.; Kolosova, T. S. (USSR). Farmakel. Toktihol. (hfoumo) 1969. 32(4), 465-7 (Russ). Rato and mice exposed to 30 mg. MctCO/1. and rabbits and guinea pigs exposed to 72 mg./l. far 2 bis. showed Increased levels of MerCO, aeetoacetic arid, and fl-hydroxybutyric add fa their .blood and urine immediately after inhalation and 24 hrs. later. In all 4 species tbe ff-bydroxybutyric arid level increased to a greater extent than did the other ketone bodies. The largest in creases in the MerCO and aeetoacetic add levels in the blood both immediately and 24 hrs. after acute inhalation occurred in rats and the smallest changes appeared in rabbits. BJJR 89620p Jfature of tbe acute action exerted on the organism by monoeihanolethylenediawdne. Tikhonova, G. P.; Sidorov, K. K. (Inst. Med.-Biol. Frobt., Moscow, USSR). Farmahot. Toktihol. (Afaseov) 1969, 32(4), 473-5 (Ri'ts). Monoethanol, ethylenediamine (I) injected into the stomach of ratt in a max. tolerable dose (2.5 g./kg. in 30% aq. oln.) disrupted the acid- base balance in the blood after 3-5 hrs., increased tbe pH from 7.18-7.35 (control) to 7.4-7.49, and increased the level of free bases. One Jay after I injection the Cm level in the scrum rv creased, the time of blood coagulation decreased, tbe blood pH dropped to 7.11-7.24, and the amt. of free bases was below nor mal. The level of globulins decreased and tbe content of albo- min$ increased in the blood; the level of chlorides in the urine decreased. I caused necrosis in the mucous membranes of diges tive system organs, probably throuch itsalk. properties. BJJR 89621a Changes in adretuline.Iike r.tstance* in rabbit blood fallowing chronic exposure to rinylchloride fntnea. Vaxin, A. N,; Plokhova, E. I. (Inst. Gig. Tr. Profxabol., Gorki. USSR). Gig. Tr. Pro}. Tobol. 1969, 13(6), 46-7 (Russ). A group of 8 chinchilla rabbits was exposed for 4 hrs. daily, during 5 months, to the vapors of vinyl chloride (1) in air at 0.02- U.U3 mg./l. Sample* of blood wire taken from the enr vans and analyzed for adrenaline (II) and adrenaline-like (Ua) substances. Before the exposure in I ami also in the control group of rabbits ^ (lie II nml Ha levels v-i.-inl lilllc ami averaged 3.5 ot't- After J 20 days i v|msurr the level n( J1 and 11a rose to tl.15 ag.'.a, after ^ 411 days it reached ti.o ag-' and it remained const, tlicrtafUr. The biopotential of the |Hrtirrinr uypulhjtanm* also changed. These rftects of I are the direct cause of hypertension. CPJR 89622r ATP and lipid contents In tbs liver of mica altar la- halation of chlorinated hydrocarbon*. Ogata, Masana; Torr.o- k'jni, k'atsuinaro; Watauabc, Slou-aku (Meil. Sell., Okayama Univ., Guyatna, Japan)..- Ini. Health IKaivataki, Japan.) 1968, 6(3), 11G-9 (Eng). The hepatic ATP level decrease and the onset of fatty liver as indicated by the increase ir. the amt. of the total lipids and triglycerides in the mice exposed to 3 kinds al .chlorinated hydrocarbon* are in the following order: CCh, tetrachloroethylene. and trichloroethylene. The total lipid and triglyceride contents increased proportionately to the fall in the ATP level before and after the exposure to 3 kinds of chlorinated hydrocarbons. It was suggested that there is some dak rela tionship between the decreased hepatic ATP levels and the de velopment of fatty liver in chlorinated hydrocarbon poisonings. B. V. Shitty 89623* Influence at subacute Intoxication with mangenou chloride and carbon tetrachloride on the lethal dose of fiptotit, lanatoaide C, and strophanthoside in guinea pigs. Lencc, P.; Vslentincic-Budihna, Metka (Med. Fee., Ljubljana, Yugts- - slavia). logostar. Physiol. Pharmacol. Acta 1968, 4(2), 157-64 (Eng). In guinea pip tbe toxicity of the title cardiotonic gtuco> sides is modified in subacute intoxications with MnCh and CCL (when evident morphological change* are restricted to the liver). The following doses were tued: 0.01 ral./kg. CCU in 2% od sola, and 0.003 g./kg. MoCh in 3% aq. sola,, i.m.. twice a week, or 10 JO times successively: glucosiles were administered 30-39 days Qo after the last dose of CCU or MnCU. In intoxicated guinea ptgs the lethal dose of digitoxin did not differ significantly from that at w controls. The lethal dose of lanatoside C was significantly a smaller only in CCU treated animal* and the lethal dose of xtro- tr phanthoside was significantly smaller in both intoxicated groups 2; G. Mnaeevie ?? 896241 Antidotes for phoagaat-fadneed pulmonary odemi Jj Boyd, Eldon M. (Queen's Untv., Kingston, Out.), J. Phan e.\ Pharmacol. 1969, 21(8), 557 (Eng). Death rate* from phosget were reduced in rabbits, cats, and rats if the animals were allow to inhale the phosgene through the no* rather tbtn directly is the trachea. David B. Sabin* 89625U Deraethytphilleln. Puchinger, Herwig; WMand, Theodor (Univ, Frankfurt, Frankfurt. Ger.). Jottos Liebigs Ann. Chem. 1969, 725, 238-40 (Ger). DemeiiylphaBora-'/f (I) was obtained by redn. of the CO group of ketophalloidin with H-Iabeled NaBHi- I had almost the same toxicity as phalloidfa. During storage I gsve a degradation product whose uv spectrum indicated a sulfoxide structure. BTJG 89626v Hlstochemkal study C cytochrome uridine and succinic dehydrogenase activity in encephalon of rabbits potooood by alcohol. Lo Memo, G-; Chian, A. (Univ. Catania, Catania, Italy). Hed. Leg. Aukuramoai 1968, 16(3-4), 163-72 (Eng). An increase in both cytochrome and succinic dehydro genase was observed in the cells of the cerebellar cortex of rabbits which had undergone either chronic or sente ale. poisonfag, as compared to the noopmsooed control animals. No change was evident fa other encephalic regions. The increase of these ts- symes at cerebellar levd agrees with the symptomatologies* data indicative of functional damage of the area during ale. poisoning. Murrie W. Burgas 89627w Nicotine degradation In hamatera and rat* and Ito modification by foreign anbatoncea. II. Effect of carbon men. oxide treatment of the animate on their nicotine metaboHsra. Harke, Hans P.; Frahm, B.; Schultz, Ch.; Doatemrill, W. (Inst. Wim. Foreehunxxtelk Verhand, Cigarettenind-, Ham burg, Ger.). Notonrisscnschojle* 1969,56(8). 418 (Ger). Deg. ndetioo of nicotine to eotinine fa rat and hamster Ever homog enates waj not affected by prior exposure to CO. GKJG 89628X Toxic effeeto. of cakfmn, titanium, and aioolem boride* fa rats. Kasparov, A. A.; Zhilovm, N. A. (USSR;. Nor, Danmyt Tohsihol. Path.' litiol. Ihh Sotdin. 1967, 152-W (Russ). From Rtf. Zh., Farmahot., Khimiottr. Srtdttoa, Toko- hoi. 1968, Abstr. No. 7.54.77V. LEU. of CaB* (I). during Lp. admir.irtntioci to rats, was 1.045 mg./kg. Ictozv-ation with a is expressed by depression and disorder in movement ccnrdina- tion. Chronic oral administration of I to rabbits (100 mg./kg day for 4 mooths) caused leukocytosis, lymphocytosis, moan in concn. of wy-globolin* and activity of aldolase, sad decream in albumin in blood. Prothrombin iu blood at beginning de creased and then increased ", ih; end of expt. In lungs there was polyemia - A tissues and thickening of interalveolar septum*. In intestines there was sclerosis of an vessels in submucosal layer, decreased glycogen fa liver, and nccumaiitiea of add mucopolysaccharide* fa the region of hepatic triad. Moderate intensification of lung pattern eras observed by x-ray studies fa animals 6-9 months after single intratracheal administration to rats of Ti boride (II), Nb boride (III), and csp. of I (50 mg.L R&S 028234 cnee* in llir f.Hty acid compn. 6f the brain between HCN- Kuii.l ami untreated rati* N. Constantsa*. I utSii Curative antigonizslion of liver damage caused by philloidin with silymsrin 11 a model of sntihepatotozin therapy. Vugs I, CrueiitInr; Tciniiie, luge (litul. lint. Mailaus, Cologne. Gcr.). Annum.-Foruh. 1069, 19(d), 613-15 (Ger). Silymarin, the antihepatotoxic agent in the leedt of Silylmm marinnum, prevented the toxic effects of phalloidtn in mice. Silymarin was also effective in revi nny the toxic eiTccti of phalloidin in mice intoxicated first with this cninpd. and then treated with sily- titarin. The antiphalloiilin effect of silymarin depended on the tune interval between intoxication and treatment, and on the degree of liver damage. BQJC 1 UdSJp Evidence for the bioactivation of slaframine. Aujt. Steven D. (Michigan State Univ.. East Lansing, Mich.). Bio- rktm. Pharmotol. 1060, 18(4), 929-32 (Eng). Max. salivary activity in pentobarbital-anesthetized cats occurred --1 hr. after i.v. administration of slaframine (0.3 mg./leg.); the dura tion of salivation was extremely long, usually lasting for 6 hr*, after a single doise. In addn. to salivation, most of the exocrine glands were specifically stimulated by slaframine. Upon ad ministration of slaframine to cows, sheep, and goats with pan creatic cannulas there was also a substantial delay before an in crease in pancreatic flow was observed. In mice, a longer delay occurred after i.v. injection of 2 mg./kg. than'with i p', adminis tration at the same dose; this delay wagpdecreased by injection directly into the portal vein. Delay of the effect of the drug at 4 mg./kg. was significantly extended by briefly isolating (with clamps) the liver of rats; the effect was completely eliminated by the permanent isolation of the liver. Common inducers of liver drag-metabolizing enzymes consistently reduced the delay in the induction of salivation in mice, while inhibitors of the en- xymes consistently lengthened the delay. Thus, slaframine seems to require activation by the liver before stimulating exo crine glands. The enzymes involved in this activation arc probably those responsible for the metabolism of most xeno- biotics. BYJN 113454q Metabolism of phospholipids in the brain and liver of rata doling intoxication with orgaaopbospborus compounds. Dvorkin, V. Ya.: Tofilo, A. P. (Pavlov Inst. Physiol., Lenin grad, USSR). ByuU. Eksp. Bui. Med. 1969,07(3), 50-2 (Russ). Organophosphorus compds. LG-63 (5 mg./kg.) and GA-81 (0.4 mg./kg.) administered i.m. to rats did not affect the level of 1 phospholipids in the brain and liver or the rate of restoration of phospholipids in the brain. The metabolism of phospholipids in the liver was increased 24.8% by organophosphorus compd. LG-63 and 32.4% by GA-81. The increased intensity of phos pholipid metabolism may be connected in some way to increased activity of the hepatic cells during detoxication of the cholin esterase inhibitors. BJJR 113455r Toxicity studies in mice treated arith l-d-o-axabino- furanosylcytosine (ara-C). Leach, William B.; Laster, W. Russell. Jr.; Mayo, Joseph G-; Griswold, Daniel P., Jr.; Schabel, Frank M., Jr. (Med. Center, Univ. of Alabama, Birmingham, Ala.). Cancer Res, 1969, 29(3), 529-35 (Eng). Optimum therapeutic dosage schedules of l-O-D-embinofurano- sylcytosine (ara-C) administered i.p. in mice (15 mg./kg., every 3 hrs. for 24 hrs.) result in karyocrhcctie damage to the crypt epithelial cells of the intestinal mucosa. This damage Is moat severe at 4 hrs. (earliest observations made) after the end of the 24-hr. course, after which there is a rapid recovery to completion in 72 hrs. The damage is thus transitory and resembles that of hydroxyurea. This cycle of transitory intestinal damage fol lowed by recovery occurs after each therapeutic dosage schedule of ara-C as long as the schedule is not repeated more often than every 4th day. Progressive damage to the intestinal mucosa accompanied by changes in the hematopoietic tisanes occurs only if this optimum therapeutic dose (15 mg./kg., every 3 hrs.) is continued uninterrupted to the LDm dose (360 mg./kg. in hrs.) and beyond. Irreversible changes are seen in the in testinal mucosa, and a progressive depopulation of the bone marrow with ultimate aplasia ensues as the LDur dose is reached and surpassed. RCTT 113456s Effect of butylated hydroxytoluene (BHT) on rat liver cytochromo oxidase activity. Pascal, Gerard; Terroiae, Thcrese (Centre Rech. Nutr.. C.N.R.S., Bellevue, Fr.). C, R. Arad. Sci.. Pant, Str. D 1969, 268(11). 1529-31 (Fr). The oral administration of BHT (0.05% in the food, a concn. 53-fold greater than that authorized for human food) for 8 weeks caused * 13.4-22.4% decrease in hepatic cytochrome oxidase activity n rats of both sexes. The addn. of BHT to rat liver homoge nates at the level of 10 mg./g. liver caused a 12% decrease in cytochrome oxidase activity. Thus, BHT appears to exert ar. antioxidant effect on in vivo metabolism. DFJF I13457t Activity of guanine deaminas* In rat kidney, liver, *d blood during experimental ursnyt nitrate intoxication. Hi slide, Jinine; Bastide. Picn-e (Fac. Mixie Med. Pharm., L'trinont-Ferrand, Fr.). C. R. Sat. Biel. 1968, 102(5-6), UU9-71 (Fr). Guanine deaminase activity (I) was studied in Ihe liver, kidney, and blood of rats during exptl. intoxication with uranyl nitrate (1 ml. i.p. of a sola. coot*. 2 *./l. pa too *. Uxly wt.l. As curly as ;'! hrs. later a pmwrwtf clevatioa d I was noted in all orituns, lmt there was a define* lowerinC rd I in the kidney fur the first 12 hrs. after the start id intoxication. Dorothy J. Uuchuntn-Davidson 113458u Excretion of tetraethylgermaniiun is the rat. Oas t/in, J.; Clivcl, M. J.; Pitet, G. (Centre kerb. Toxktrs, C.N.K.S.. Toulouse. Fr.). C. R. Sat. Bird. 1968. 1lU02J(t5a-6o)j, 1226-9 (Fr); ef. G. 1'itet tIWo). KtA-e tl). a very rej com|id. in vitro, is degraded very easily in the nt. All! has a very Inch h.p., it is eliminated in large aints-duringcirnPR- tion. The mrtalwhtcs of I found in rat urine are GeOi or the grrmanates. The metabolism of 1 is different frun that of tetra ethyllead (III or tetracthyltin (III). No evidmee was farad for the formation of tricthylgermanium, which explains the weak toxicity of 1 compared to u and 111. Dorothy J. Buchanan-Davidjr* 113459V a-Hydroxybutyrate dehydrogenase activity of rat kidney homogenate fractions after experimental uranyl nitrate intoxication. Bastide, Janine; Bastide, Pierre (Fac. Mate Med. Pharm., Clermont-Ferrand, Fr.). C. R. Sac. Biol. 1968, 162(8-9), 1492-3 (Fr). Most of the a-hydrosybutyrate de: i hydrogenase activity of the rat kidney is found in the so; natant after centrifugation at 24,000 g for 2 hrs. This activity decreased with time during exptl. uranyl nitrate poisouiag, whereas the contents of protein, DMA, and RN'A were relatively low and underwent but little variation. C. W. Acketwra - 113460p Effect of ethyl bromide on Ae liver. KarimulEaa, K. K.; Gizatullina, A. A. (Ufira. h'aoch.-Isdrd. Inst. Gig. ProfzaboL, Ufs, USSR). Farmaket. Taisikel. {Moscow) 1969, 32(2), 165-7 (Ross). EtBr fumes (2.4 mg./L) mbalcd by rats and rabbits for 4 hrs. daily for 6 months disrapted Ae fne- tiona! ability of Ae liver, decreased the hepatic glycogen aad fat levels, and prolonged hexenal sleep. Gnmlar dystrophy in Ae hepatic cells and a decreased RKA level ia the cy tuple-- were detected. BJJR 113461q Hemopoiesis in chronic heliotrine p-t---j"g M Wistsr rats. Levin, G. S.; Kovacbenko, Z. 1. (Uib. Naach-- Issled. Inst. Gematol. Pereliv. Krovi, USSR). FarmakoL Toksikci. {Mourn*) 1969, 32(2), 170-1 (Rum). Heliotriac administered at 3-10 mg./lOO g. once a week far 1-8 % to Wistar rats caused hepatic lesions, hypochromic smi-- cs severe retieuloeytosis, normoblastosis, and letikopona. Erythre- blastic sprout hyperplasia, an increased no. of mitoses, and ms increased no. of reticular and esp. plasmatic cells were oWmd ` The observed changes in Ac blood and bone narrow suggest F development ef an autoimmune form of hemolytic anemic tk response to chronic heliotrine pensioning. BJJR e 113462r Benzene metabolism ia the Ever ef txaniamkl animals snd assn. Tiunov, L. A.; Sokolova, T.I.; F A. L. (USSR). Farmakci. Tekiikal. (Moscow) 1969, % 185-8 (Russ). The rate of CeHt metabolism timing 24 . incubation teas similar in Ever homogenates from hnmans sad t rats, more rapid in homogenates from guinea pap, and doner mi in rabbit liver homogenates. Species-specific difltrencea teemed to be involved in CH* conversion, since Ae acthntica of aryl 4 B hydroxylase and ghieuronyltransfense increased while Ae snlfonatlng system activity did not change in CA-treated rata, la GfHrtreated rabbits the. sulfate adenyltramderase and tat R itfotraasfcnxe activities decreased during dAxprion of sulfooatiug system. The high rate ef CH conventon A guiaea pigs may be connected with Ae relatively high fiver catahm activity. BJJR 1134638 Effect ef Ae sodium salt of adenosine triphuipkrto on experiments] cyanide poisoning of rats (mothsnism ef An satidotsl action). Mosketi, K. V.; Gcnxhara. P. S. (Odesa. Med. Inst., Odessa, USSR). Farmaket. TaksOst. (Moscow) 1969, 32(2), 214-15 (Russ). Na ATP (0-5 ml. rf a 1% sohu) given s.c. or i.m. to rats 1 hr. prior to administrsrioo of the aria, lethal dose of N*CN' prolonged mrvival. When given *.c. im mediately after leAal cyanide poisoning it mbstaxmOy extended Ae life span ef 50% and prevented de*A A Ae other 10% ri Ae rats. The antrdotk effect of ATP may malt Aon is ability to restore respiration by bypassing cyanide-sensitive rnrymer BKJl 1134641 Changes A Ae csrdlac sctfvity ef mis chronkaly exposed to vinyl chloride vapors. VaxA, A. X.; Plokbova. j E. I. (Gor'k. Kauch.-Issled. Inst. Gig. Tr. Prof-Zaboi., Gonki. C USSR). Farmakal. Toksikat. (Moscow) 1969, 32(2), 220-2 (Russ). Chronic (5 monAs) exposure of rats to vinyl chloride vapors at 0.00-0-04 mg./l. disrupted cardiac work rhythm, A- duced bradycardia and arrhyAraia. and reduced the idative duration of 1-11 and T-II sound intervals. The relative dma- tion of Ac Q-T complex did not change significantly. Within 15 days after termination of poisoning. Ac rat cardiac activity rhythm returned to normal, but the duration <d Ae I-It snd T-II sound intervals remained below Ae initial level for another IS dayi. The maximal permissible coocn. of vinyl chloride apparently is significantly lets Aan Ac 0.03 mg./l. level tov- viondy rtf. BJJR 14--TOXICOLOGY T. *. TWKBUON 41109* Toxicology of vinyl chloride. Schottek, Wolfgang (Abt. Arbci'itoiikoL, Hotxwcisslg, G*r.). Cktm. Tech. (Ltip' {() 1969, 21(11). TOS-lt (Ger). A review with 24 reft. The toxicity of vinyl chloride in uinuh end humane, end the relation of the chem. structure of the compJ to its toxicity were die* cursed. CCJG 4111Qr Microscopically contrasted heavy metal intoxication. Silver sulfide process, a method for L 'sliced hlstechemical ds- tectioo of heavy metals in tissues. Haider. Gerhard (Ger.). Mihrohosmos 1949, 58(9), 272-5 (Ger). A review of work is pre sented which illustrates the value of the combination of light mi croscopy with histochem. techniques for the detection, localisa tion, and identification of Hg. Pb, Bi. Pe, Zb, and Cu in cells and tissues. Highlights of the silver sulfide histochem. procedure are presented along with representative photomicrographs. S refs. Nellie G. Dehnbostel 41111a Development of the hemodynamic, bioehamical, and morphologic change* in experimental endotoxin shock. Sten- gert, Knysttof (Z Zakl. Anest'cxjologii, AM, Lodx, Poland). Posupy Hit to**- 1969, 23(5), 601-59 (Pot). A review is given of methods for detg. hemodynamic, .bioehetn., and raor- phot, changes, the course of changes in dags, clin. evaluation and patterns, and damage to tissues and organisms during exptl. endo toxin shock. 146 refs. Y. Pomeraa* 41I1XC Saponin*. Birk, Yehudith (Hebrew Univ., Re- bovoth, Israel). Tone Const. Plant Foodst. 1969, 169-210 (Eag). Edited by Liencr, Irvin E. Acad. Press: Hew York, N.Y. Dietary source, metabolism, and effects of various tapo- nins are given with methods for qual. and quant, analyses. 167 refs. B. A. Hodgdon 41113u Chromatographic identification of psychotropic drugs. Phillips, Ceoffrey F.; Gardiner, Jane (Lab. Govt. Chem.. Lon don, Engl.). J. Pharm. Pharmacol. 1969, 21(12), 703-807 (Eng). The thin-layer chromatog. of 3 classes of psychotropic drugs, phenethylamines, tryptamines, and erganes, has been in- vmtJgsted. Published methods are reviewed and X/ data, nor malized by a graphical technique, are reported for extensions and modifications of some of these systems. Optimum forensic sort ing procedures are recommended. RCHQ 41114v Estimation of Isad in urine by atomic abaoraoau analysis. Taira, Yoshiko. Nippon Eiseihtnsa Gishikai Zasshi I960, 18(5), 389-91 (Japan). The Pb" was extd. into iso-Bu- COMe soln. from 30% N1LOH. The recovery rate was 99.9%. The reproducibility of at. absorption measurement was 1.4%. No interference from other ions was noticed. T. L. Chang 4111Sw Determination of toxic lutetucti and their me tabolite* in biological flulda by gas chromatography. I. Tri- chloroethanoi in urine. Sedivec, Vaclav; Pick, Jan (tfstav Hyg. Prace, Prague. Caeeh.). Prat. Lth. 1969,21(7), 301-6 (Czech). Sec CA 70:113446p. VNJZ 4U16x Aflatoxin E, in th* excretion of aflatrxin-foisooad rats. Chou, Ming-Wu; Tung, Ta-Chcng (Coll. Med.. Nat. Taiwan Univ., Taipei. Taiwan). J~ai-Wa / Htnth Hoi Tsa CM 1969,68(8), 380-91 (Eng). Afiatoxin Bi was detected in the rat urine and feces after i.p. injection of the toxin. Most of the afiatoxin B. was excreted in the first 34 hr. The percentage re covery was tbout 1.5%. A thin-layer chromatographic method James A.; Seifaold, H. R. (Tulane Univ., Covington, La.). ToxicM. Appt. Pharmacol. 1969, 15(3), 624-31 (Eng). Ttt toxic effects of ethylene glycol in several macaque species are re. ported. The compd, was administered in the linking water at concn*. of 0.25-10%, and histol. studies woe made after acate and chronic administration. With the exception of a few animal, (which had Ca oxalate crystals in the brain), significant paxhol. alterations were limited to the kidney*. Animls receiemg I.j ml/kg or more of ethylene glycol had Ca oxalate crystals wuim proximal renal tubules and assoed. tubular degene.ation. De spite the absence of cryitals in animals receiving <15 ml/kg. add glomerular damage was found, and azotemia occurred in sane animals, suggesting a toxic effect of ethylene glycol apart from its conversion to oxalic acid. RCZB 41I20u A clinlcopathologic study of the effects of riot control agent* on monkey*. IV. o-Chlorobenxylldsna malononitrfle (CS) grenade. Striker, G. E.; Strcett, C. S.; Ford, D. F.; Herman, L. H.; Holland. D. R. (Edgewood Arsenal, Md.). U.S. CUarinihonsc Fed. Sci. Tech. Inform., AD 1967, AD-83S- 732, 39 pp. (Eng). Avail. CFSTI. From UJ. Coot. Res. De velop. Rep. 1969, 69(19), 123. A study was (bade of the order, severity, and resolution of pathol. changes in monkeys exposed to CS. Monkeys were exposed to CS (2700, 8300, 28,500, er 80,000 mg nun/m*).' The most prominent It limit seen after the 2 lower dose* were m3d pulmonary congestion, brondborrbm, emphysema, and atelectasis. Them lesion* cleared by 72 hr but recurred at I week and 30 days. Oral and nasal discharges aad dyspnea appeared early after a level of 28,500. They wtre mast severe between 12 and 24 hr and were resolved by 72 hr. Pneu monia. emphysema, and atelectasis were promt 1 week and 30 days after exposure. Significant lesions were men radiographi cally only in those monkeys exposed to a levd of 80,000. Them lesions paralleled those seen on necropsy. At this level erimi appeared by 12 hr, peaked between 24 and 48 hr, and cleared by 1 week. Emphysema and faroochiolitb were present 1 week aad 30 days after exposure. TCVL 41121v Experimental study oa gas smboflam with partksfcr rafaranc* to too differentiation between emboGc gta and pi from putrefaction. Pierucd, Giovanni; Cberson, Gemma (Imt. Med, legale, Univ. Pavia, Pavia, Italy). ZacrKi 1968,13) 40), 347-73 (Ital). Embolism was induced by injecting air or He i.v. into living (followed by instant death), and Lv. or intracarfi- ally into sacrificed, rabbits, and gas was aspirated from the heart at intervals. Putrefaction gas was aspirated from the heart md abdominal cavity of rabbits and human cadaver 1-13 days, sod 15-236 days, after death, reap. In samples of sir emboGc gas, Oa decreased and 1 hr aIter death was insignificant; CO, ns present immediately; Ni levels wtre relatively stable, ximdar to air, for 2 days, then decreased sharply. In He embofic gas. Os, Ni. and CO. were present immediate/. Results were essen tially the same fat rabbit* injected before and after death. At. values for putrefaction ga* contents in rabbit aad cadaver hews were, reap.: Oi 1.32 aad 2-05%, Ni (usually <50%) 12.13 and 22X6%. CO.3l.08 and 5042%; CH, appeared early and i' constantly fat the rabbit. F. Fa 41122W Early affects of carbon tatrachlorid* an th* i was a simple way for detg. the afiatoxin concn. of tlw excretions, and could provide useful information for detecting it in humans. N.M. Wright 41117/ Paper chromatography of Taxes baccata toxin. Bn- bien, Zewn (Wyxsxa Sxk. Roln., Wroclaw, Poland). Zeis. Nan*. IFysm. St*. Re/a. HVociawt*. Wet. 1968, No. 23, 215-21 (Pot). The presence of toxin in 7Macce<a (English yew) needle*, in fodder, and in the alimentary tract content was detected by paper chromatog. The alkaloid was extd. from the biol. ma terial by EtiO, purified with active C, and chromatographed in the form of aq. HCI soln. The chromatograms were developed at 18* by the ascending technique, using as solvent either BuOH- 80% AcOH-anhyd. EtOH-HjO (50:7:2:15), or 75% aq. (NH,V SOt, The R, values were 0.95 and 0.75. reap. The toxin spots were stained by the Dragrendorf reagent. Irena Klocako 411181 Errors of converting a urine alcohol value into a blood akohol level. Kaye, Sidney; Cardona, Eduardo (Sch. Med., Univ. Puerto Rico, Rio Picdra*. P.R.). Amor. J. Clin. Pathol. 1969, 52(5), 577-84 (Eng). Evidence is presented for the in- advisability of calc*, blood EtOH levels on tne hub of urine BtOH content. EtOH content was detd. in the blood end urine of 148 patients and the ratio of orine/blood was cakd. The range of ratios was 0.21-2.66 with a mean ratio of 1.28. Blood levels were cak'd, from urine levels using a conversion factor of 1.28 and compared with measured values. Cakd. values ex ceeded actual va'urs by at least 00'-' X ;nil in 21.5% of the cases and Herr loner by the same amt. in 34.5% of the case*. J. K. Macnab 41119a Etbylen* glycol toxicity in the monkey. Roberta, Biephys. Acta I960.187(4), 584-7 (Eng). In rata, i.p. injection of CQi In doses as low as OX *1/100 g reduced the ability of Ever microtomes to incorporate cboCne-T into total phospbaGpid* and labeled L-leucine-l-"C into protein, dimnut as early as 10-15 min postinjection and lasting for 220 hr. Ineorponemn pattern* of choline mete identical whether the radioactive choLrw was labeled in the Me groups or in the 1,2-carbao atoms. The magnitude of choline inhibition seas not attend by varying the dose of labeled choline over n lOOMold range, attesting to the independence of this phenomenon of the attendant variations m the urterual pool size of bee choline. Ethioninc (1 rag/g) and dlmcthyhitrosaminc (10 mg/100 g) did not affect the incorprotion of choline into liver phospholipids, although they mhibiad protein synthesis. CCL enhanced the incorporation of ethandamine-f-MC into liver microsomal phospholipids. The early set.and the long persistence, as well as the specific nature, of the Ar rangement of phospholipid synthesis by CCL suggest a possftk rote of this phenomenon in the pathogenesis in fatty liver. BKJS 41123s la vitro inhibition of succinate and pyruvate uiUatisn by etkaaoHc vxtrac-a *f grssaas. legumes, and dyatropbsgsK foraga*. Checkc. Peter K.; Oldfield, James E. (Orcgw Star Univ., Corvanis, Oreg.). Can. J. Anim. Sci. 1969. 490.4aM (Eng). EtOH ext*, of title plants inhibited m vitro ovdn. vf both succinate and pyruvate by rat liver huiiiocnuii-s.. Ens- '* 2 dystrophogenic forages did not inhibit succinate oxidn- ns*1' than those of two noodystrophogeuk: sampler. The : :oj (Aff. is. iiI TOXICOLOGY miia R&S 028236 rleaniiw, k)dr'aullr wash-out) and hyglesle (anll-Aist respirators, proirr'ltr paitrs) irfuurn wrre recommended, Introduction o* suck measures si i number of rlrrtrle powrr stations IwlH <o d; iilklltj reduce the rnncrniraiton of fuel and rlnder dual In the atmosphere o( knrl prrmijra and in do away with aru*e and chronic eerupattnnal dlft --s.--C. M. M. ,9. PAVIOVA. L P. IM. M. Etrndl-rJdr Inal. |nd. Hv*. Orrup. Di., Sumv^li. USSR.) Matrrlalv k otmsnovahlvu prrdrl'no d.pu-iimnl konlftentral-itl dllfnprnpllbmaolnv v vnutukhc proltvodal- irnnvkh pon>r*hrhrn||. IMl'frM-. (nr ralahllnMnp the maximum pf-rnii-.-IMr ftofi w1 ration nf Ons-pn-pvl Ur.iirnrii in Ihr air of industrial prfnib*^.] Gifl TP pllAl /.A DO 1- 14121: ildl. I.lua. rn. Ji Thn comparative Inalellv ol m- and p- Dipn |diiM^ropvlbrnmnca| wan atudird at lethal, loxlc and thresh- old concentration* and dosage*. DIPD am virtually devoid of cumu- Uilti-tJpablUty. Chrmle acllnn of ihrlr fume* al a concentration Id I mg iprodutrd'CNS Inhibition, disturbances of the anti toxic-sviuhrilc and protein-forming funeilon of Ihr llrrr and ftharpty pronounced primary Irukocyloili with subsequent tendmey toward* Irukrpenli, Cunri rUrallrm of 0.2 Rif I waa Ihr threshold value In a chronic leal. Dim (O.OS mi D wan ihr recommended maximum permissible conrrniration lor ihr aimoaphrre armnd-work placta. ~C.2f.M. .46320. SIM I'SON, G. R. (Di, Occup. Hrsllh, Ltdeombe.N. S. W., Aum.l Emmurr lo dust Is Ihr civ ion-camriling Industry. MED J A 1ST 57-1(23); 1151*1152. 1970.--Six eotion-firnetllnf plants were examined and cotton-dux! concentrations of lo 21 mg'cu m wrre recorded In the ln-ptxM almoepherlc breathlng-aone. Tests of ' lung (unction of Ihc operators showed an over-Hill average fall of forced expiratory volume [FEV)| of 0.12 I. In mor- duly areas, an average fall in FEVi of 0.211 waa recorded. Al dual concer*rmuons In Ihr vicinliv of 6 mg ' cs m, liiflr change in FEVj occurred. As the alr-dMrne dual waa not entirely raw cotton, a figure of 5 mg eu m of coil on dust In air la suggested ae a tentative thresh old value for this type of work. Thr use of eahauit rrntltatliv is rrcamm aided lo reduce thr cone ml ration of cation dust In air --C. If. M. 46321. MEL'NIKOVA. M. M., 1. S. IVANOVA, and B. A. YAMPOL'- 5KAYA. ICeni. Inal. Postgrad. Med., Moscow, USSR.) K kUnikr khronlclirakoi intokalkalall oklt'yu uglrroda, [Clinical picture In chronic carbon moncsldc polaoetng.l GIG TR PROF ZAIOL "11(0)5 23-26' 1970, |EngL *ura.|--Results of an examination of 266 wo- i mgaged In aervtelng taxi-llrrt garages of the elty ad MI , whose oeciqational activities Invoiced their being exposed o the effect of elevated conctsfrallcns of CO txhauat pa are pre sented. A high incidence of functional disorders Implicating the CMS, appearing In conjunction with vrgrtailve-vascular dysfunction, hyper tensive reactions and ECG signs of focal and diffuse myocardial changes, was noted. A high carboxy Hb level In these persons coonrm-d thr etiological role played by CO In the development of these changes.-^. M. M. 46322, BLAGODATW, V. M,, I, A. GOLOVA, N. K. BLAGODATKINA, E. P. RUMYANTSEVA, U A. GORYACHEVA, H. K. AUEVA, and E. 91. GRONSBERG. final, lad, Hyp. Occup. Dta., Gorki, USSL) Ycproay glgteny troda 1 profpatologll v proigvodstvc orpnlcheakego Hekla, [Isaurs of Industrial hygiene and occupational pathology In *he manufacture of organic ifckI GIG TR PROF Z>BOL 14(g): 11-14. 1970. [EngL um.l--Foar fadorlrs manufacturing organic glass 'poljmethyUcrylate) dextlaed for dlfferenf purposes wars reviewed. A feature common lo all of them waa air pollution la work pn-miaes with mrlhyhn-fkacrylale (MMA) furn is. Ra coocesfrotioo varied within a wide range. MMA produced ao adverse effect co the health of the workers, manifesting Itself In the develcpmeaf -f chronic occupational poisoning.--C. 3f. St. 46323. GUKSltTFIN, M. I). aarJierye iwnhennurtl artcrlai'ango ifHHih* u Nistiissls hikh a malivu-rnviHvml neflvaml. |Lrngth-*i4--rill , r, Lii.vt iioiurm -if 'hr arterial Iihmh lii uersunn wvirkiim' wiili |.iw--ullur iiiHruliwni.i lit AZf./tll KAtK'n-fSh'LCD InVi Cig TR HiOrZAiOL"V H=T4. INS. From: REF EH OTD VYP FARM \KOL KHIMIOTER SREDSTVA TOKSIKOL, IS70, No. I.M.ISII, 46324. KHLEONIXOVA, M. L, E. V. GLADKOVA, L. T. KURENKO, A. V. PSIEN1TSYN, and B. M. SHAUN, float, tnd. Hyg. Occig). Dia., Gorki, USSR.) Vcprssy flglmy tr'c*a I sostoyaike ftdorov'ya rahnchlkh v protivodatvc o-toMdlaa. 1 Problems of Industrial hllift* aad health etatus at workere rnglgwl In lit production of ^lOT-in--r--.T-----C--I-G--T---R ra--o-r ZA B-OLL-' Tflt: rzvrimnTB5T | awn. J--Work ctndltlnss and health status of workers sngagN la the 'production of odotudlse were studied. The air of work prwlaea c-na`--0 laertssed cokratratIons of o-tohtldiae aad o-oMolaeoa. Van kert demonstrated dyasrlc manifestations, Initial patho- Fade, .iterations cf the urinary bladder mucosa and. Is Individual nitancrft, bladder papillomas, Thcae changes and disorders wars rf an occupational nature. Cp<cUI experlmetSal Investigations are nrrdrd lodrtrrantnr Ihr eatrid if *;ir haaard caused by rarh rntutdiae laomcr In regird lo Ihr drtrlqpr rnt of urlnarv bladder tumnra. --C. M.M. 46225. AGARKOV, r, T., arrt S. V. AGARKOVA. fA. hf. Gnrkll Med, Inal,, Donetsk, USSR.) O Imiperaiurr wdikha.-m.go intikMi I kondttftlmlrurUfthchel funklnll dvkhatel'nogn a|>paraia rdiriivd^k I bol'nvkh pneymehnnlnanm xhakhterov, ITrmprraiurr nf rihi^H air and conditioning function of Ihr respiratory lprnn-ilusTSTS^M ftndpnrumnconlfinlftsafleetrd minrrn.1 QIC TH 1`ltOF /.AIOL If (21: 21-31, 16701 (Engl. sum.|--The rxplrid air temperature waa registered In 064 practically healthy and pneumncnnln*tnHiffecird misers by an rlectrolhcnnnaidcr provided with a highly sensitive and low-incetla thermlalor sensor. This waa paralleled by thr mraaurcmrnf of vital capacity of Ihr lung*. Thr data obtained formed a baala fo- determining rrarrvr conditioning potentialities of Ihr respiratory ayatrm. Thr rxplrcd air lomprraiarr lo practically healthy mlncra la appratlmately thr aam ? aa In normal subjects not mpiid la mining, sversglrg 14.37* 0.03'C. In parumoconmla and Ita progrraalvr development, the temperature of expired eir goea down, Thia la accompanied by a dlallnct drerraar of merer conditioning possibilities of the respiratory system. Thr im malty with which the conditioning function declines augments aa the pro cess of pneumoconiosis progresses In lls development.--C. 34. M. 46338. MARIN, A. M., aad A. O. NAVAKATIKYAN. (Imt, Ind. Hyg. Ocon> Gi*>> Donetsk, USSL) KUnlko-fliloIoglckcsknya kharakterlsIlkB pylevogo broNklta u padxemnykh rabachikh ugol'nytt thlUl, [CUnjcsI^ftTalolodexi characteristics of dsaf-liidocsd bronchUla la fftrtrond coal mtsera.1 blf* fit Fwr iUbOL 14(1): 26-3i. iffioT I EngL #isa.|~Pmlientft |70| with chronic dwst- Induced bronchttla of long alindlng were reported. Transformation into (17.1?) aid suspected pnctsaocailaals (1.17 of cssesf were nofed after a lapse of 1-5 yr. la potlcnta with bronchitis exhibiting no signs of pulmonary fibrosis, non-diseased miner and practically hokkhy IndlvtdNt* with ao service record ia ao atmospheric enrtrenmsflt of high dustiness Ihc vital capacity of the lunga (VCL), restdiml air (RA), total hang capacity (TLO, maximum volsm-trlc expiration rale QHVER) and maximton volumrtric losMrafloa rare CMVIR) we.-e datermlnod. Wkea measured, Ihrft- indices wrre contrasted against the due values. A distinct rise of RA aad an agweeiabty fall of Ihc VLC, MVER and MVUt were re -. drd la patlems suffering frees chronic bronchitis. Iscresaad RA figures were registered also la aon^ilaeaaed miners with long servtce-record, proving exrty development of maallcataUeos typical id emphysema aad deranged pulmonary ventilation.--C. M. M. 46227. KHENOKH, E. A, Glglcnlcheskaya otseofta ralovil Iruda rabctaytubchlkh prl mokrykh pratsessaJdi mtUualc5ital& obrsbotkl ixdelil la stckla I khrystatya. [Hygienic evahatlon working conditions In wet machining processes at class and crystal wareTT CIC TR PRQrtABOL 1 HH):~4?-. 1WD. ^ --wet processes of marMnlag class, crystal and quarts ware (grinding, polishing aad Mew Jig) are accompanied by consider able release cf qmrtx-cfwUaloing dust Into the air of lbs work rooasa. Grinding and poBehlag are dime mostly by hand aad rsqidrs appre ciable physical exertion on the part of the workers. Tbs considerable release of that makes It necessary lo equip the plafhg art polishing equtpmmf with crtiaurt tans. The occupaHoas cd grinders aad poUabers should be lncktded among those that are detetertow. These workers most todergo maadxlory prehmlimry md pm ksSc medical examInalloos.--J. S. 4622* OflRJOVA,N.A.,aniH. P.GRANDC. (Gorki ta. _ lod. Hyg. Occnu DU., Gorki, USSR.) Ob ctdalennykh posisdsl- C vlyakh profeaUmrtl'nykh Odtdykk aravlenU sikrinryml sglrre- <S dorodaml I ikh profsrodnymL [Long-term aide eflects of yute QcCTgmtlisml polamitnc by certain hydrocarhans and tbcjr dcrivaitvrs.l GW TR PROF ZADOL 24(5): 50-51. tkfbT--X sledy nf the Okie eHrcln nf ocrupMImal pnlmmlng In 25 prnwwm (uti-flnn, 6; brnxyl, 5; mrlhylrnr chbirlde, 2; vinyl rhlurtdr. 2; IrlchluriHlhylrne, ; dlchlurmHhann, 6; trtraehlororihaap, 1; chloriftnixenr, 2: polychiorobutasc, I) In reported. In all cases residual eflects la Ihc form of laartlocm! diatarbaimeo d the CM, symptoms of sympathetic-senaoey polyneuritis w orgame dis order of the brain wrre Observed. The frequency aad degree of expression of these side eflects d^enri iqKsi the severity of Intst- callon suffered, previous CNS diseases ami the lime rt retwrs lo work after aeurotroplc pcfsonlag.--C.P. 46226. ENTERUNI, PHILIP E. (Grad. SCh. PN. Hrakh, Urtv., Plttaburgk. Pm.. USA.) VaUdxtloa threahokta sslng Imlsstrial records. J OCCUP MEO 110? M-3T. Ilkm IV7g.-SSny has soma fairly accessible records width might he mefsl la estabHahlag Threshold Limit Vaksss for certain ikliilam n these are employs)art and exposure records oa retlrad pcpslrilima im rramds aa martallly In those pipuletioQs. Dels svailsMe from these records meet all the reqstremorts for good epidemiological Ibvestigallons. There mlfld even be oom* idvartage in pooBxg retlremert It'il.'Ha (hr drtrtopmrnl to pulmonary animate la rat* Mudtr* an rhaagr* I* (hr Mil, rilrrllK (r** thok-Wrrol ul pho*|hoUpld* <ere itldr In tone*. IMr M blood plnama over a period of >00 toy*. T(il rholraierol, Ml fraction* and phonphoUpid emend Incrrurd with Itela Ihr hug* of allirotle inlmiln. Illatochrmlrilly audancphllk ffiDli wit observed in the cytoplasm of pulmonary nun#iKi|, i '(tv simitar lo Iboor of hiyi wore not otmerred In liver ind blood ---'4ml: Ok Increased Upld eodtd Of lane* dirlog npirlwiMI pul* monary silicon* may br da* to fa localised UrgeneraUee artion of silica on macrophages. 1 linit. MUELLER. W,, *ndC. HOLZAPFEL. (Inel. Arbehehyt., Unit., Jrni, E. Crr.) Ueber dk Brlkhind rwtacben Iklli-Amliohn- U/iBieufT-Auatcheklung Im Rirn and BkutbtrUplrfrl b*l Arbrtlrm nil UidrrichledUchrr Blelrxpoattlon. (The rebdlonihlp bttiwn ALA In urine ind kid In blood In wtkm with different lesd-expoeure.l IMF XBCSrKRBErf5nEo~I1TOT5nSJTrnSiin57rriE5r*5Sm.|"I 1 proma of differently iqtnid lead-worker* the relationship between ALA (gamma-omlnokwUnle acid] In urlne and Pb In blood iu In* veatigited, TbU retulonahlp la sot conataid and depend* on ibe kind kd Wcnatty of riponrc, II I* dlfllcul lo ekahlXah an acee^abto Uro# value of Ibe ALA-output lu urine. Women *em more aeoetlleo lo Pbthia men. 1122*9, LtVSHfTO, O. D. O voxmathnoatl Irpol" xovanly* meatoykb pektlMOdrrxhaahchlMi pUhehcrykh produkloe e profilaMIke aatur-lxma. fThe poeirbllily of uelne beat prctln-contalnlnc food products for Ibe ^ogfeiToFTead ooUmiliw.l T'RTERH METniCr U 1M-TW. mO.TraAslated from JlEFzH OTO VYP FARMAKOL KHIMIOTER SREDSTVA TOKSnCOL, 1070, do. 10.M.5.--For < mo. lead acetal* at M mgAg m fed totragxstrkally to 2-mo.told male rata. Tboae at group l.uer* maintained on Ihe umal ration tad (boa* of poup 1 nerd given the ueual ration * IW ra earrofe. Dy Ibe end of the expoouro to Pb, the r*ia of poup 1 bad developed the aymidom* of rbrook Pb polaoolnp torpor, dtoturtanc** of nutrition, loo* of b*lr and * re duction In food eonaumptlon. During the entire period of observation all the rat* of poup 1 remained veil, gained weight and had a pot appetie. in rat* of poup 3 the dally dtareala waa 1*11 mL On Ibe 20th*2Stb day of exposure tbooc of poop 1 Mowd bypourla (3*4 ml). The average weight al the end of the experiment waa M4.1 g for croup 1 and 1(3 g for (roup 1. The kfchiey* and gaatrokteotbial tract of tbeiat* of poop 3 axereted WJ mg Pb (gj% of taut token Wo (he body) dnli of group I, <0 mg (40T>). The propbylaclk action of local ^H-eotoaining food (roducta toovld be studied for oae In Ibe there* V^Sfe-peo^iylaetk diet of workere exposed to Pb.--d. T. to mao, LOSKUTOV, N. aw N. F. WUETVAI/, Umrneni* elektrokardlogrammy pod ellyanlem krotonmltrtta 1 ixokrotooo-nltrlto. [Chance* In the eteetrocardloeram under the action of crotdnanitrito anJlaocrofonooTtrUc.l TftlStJW'WW 3EtTPET~ IT.~ -- KSl.Trinalated &om RET Z8 OTO VYP FARMAKOL KHIMK3TER SREMTVA TOKSKOU 1*70, No. 1.54.05.--to rata and guinea pig* gleca a Ingl* median lethal doe* of crotoocmkrU* (I) or taocrotooo- altrlle CD; ened to the production of aytobetk rubber), the ECC abound a reduction to Ibe voltage of the QR9 complex, aa lacreaae to lb* nm- beT of heartbeat* lo MO/mto, *a upward ahlft from the haaellrw of aegmete ST, aadfbo appoarkace of a high, pototed T wave (for 3*4 *--* *- --i i i tm latMft^Heftlh lAntl i J0 to o to QO fo CO aeregnaaaaagueoun nn* * v -- ---------------------- mo, the rot* allowed aa Increaee to the heart rote, upward dlaplaet- meto ef toe ST aegmenl from the buaeUne, aa tocrcuae to the Tj-g wave to T*P atm, a reduction |a Ibe QR3 voltage, an toereaae to lb* FQ Werval, and, to come of the animate, ataomn'kator blockade or blockade of the toft team* of the bundle of HI*. Change* of Ibto type were atoo found to guinea pice. Impulnaeid of the principal htactlooa of the myocardium Occur*; Ibe coockldlvUy, exckabiUty, autdmattam, and ccdnctlUty, thla la explained by impairment of the metabolic procesae* to the myocardium exuaed by Ibe pollening. Then to a blb- Uogmdty with 10 reference!. Front lh* Ukndalaa Mkdt lev Ibo Foatpadwt* EducalIon of Porton, XXar'ko*, USSk,*d, T. (33301 BASALAEV, A. V. (Cork! tool. tod.Byg. Occup.Dl*^ Cork. iRj Upyt prlmcncnlya krupnokadrovol nyuorogntU pel oaalrdo- uull aketota u nhotayuabcblldi e krvitakte a oepredefnymi ugtovodoramf etlkaoco 17*d* (otoftoaml) I Ikb klbtieoimbynl (kblorvinll, trlkhbretltoel. fExperlenee wltb the oae offeree-frame (fwtofluorocndbT toenmtotoc xaetelnlbone*of oeraonx occutotknxUvdaallnx wRhkto* aaturtoed bvtooearbon* ef the etovtoue aertea (plena*! and toelr ae derteatlee* (vtoyl chlorld*. lr)cbtorethvkeae)X GIG TH PROF C-WntK ~W4l, lBW.~TagL oaiu,l-Tfeae anmtoattoad n- 1 a definite reeowotrurtlna to Ole benea; oataaoetorooto, onkeo V. oak. ueXeotyxt* *ad oyotle tbengea. TraenWIMton of the Baba W prvinJeee* to (be ettnfeat polmudag pktaro of Ibeo* eympfo-- euocenled toutenn of higher vegHaflvw eetoeru. part tcutarty UOrr pnlhelamlc re*km. Three rhaacea may be of a -uT'-tyWr <tok~ omt, Largr-lramr ^Mtoduornpra^F my br rermumcruh-rt for rvrurim cal examlnaf ton# of (hr akrtotnn la ncnpalkmal croup# w*h puntix bow paibotocy.--C. M. M. 1313*3. AMIROV, R. O., 1.1. ALEKPEROV, and V. O. PITEkARtr K axnWarnOtlclenkheakol UuraUet(alike ualwlt Irm ntrxj. toeprl pokwhentl Uiaplna (IKtKhF-1). tA axnltxry-hvclenir (%tn-trr3r tton of the werhlne condUton of orrxona predwclnc utaom !IlfiilbP>-I -fo'^doJrrrlbretr/) -PTrUIntuiuJ Vr Azt.Rfl RUigU^UtfcthSg CKJ TR PROF fAOOL 3. 13V-14J. tm. From: REF a OVD w FARMAKOL KNIMlOrER SRED6TVA TOKSIKOL, 1*70, Ne. 1S4.LB1 U33. BRA(OUMOVA, I. T,, and G. V. SAiCSOHOV. Inahm olaenka vUyaulya m orCMlxm nRrldov perelhodnykh metaftoe I o*um talkn. IComeuridre atudr of the effeel of tranalUonal metal md m melallk nllrtdra on the body.) CI6 Tft FftoE lilTg: fJ-5 I7qretd. I*7l).--bi experwteida with wbke rata adrldea to u- dtla toctodtog BN, SlgNg, and WC bad weakly pronwmeed Bku- genk adtvlly and caused pnednwrntootk ebaagea. Mrial-ton auridv toebidto* TIN, ZeN and NbN I* addblon caused dystroifey to (be Beer and epChellum to the renal enuobded tubalev. The reromm ^d maximum permissible dose for nitride# touoa-aMals sad tot to U mg/m>, br ABf la 4 mg/m* and tar ZrN la 0 tog/m>. The toxto *T~ led# to nitride* correapoaded to dkelr electro* afrueturo. The bkilogtcal aetlvgy decreased wgb the Increased posstallSy to tonku 5>p*-electron canflguntlon* toirtog Interaction with N to aaa wrtiiw and aeml-melato and atoo d4-configuration# was the formwmn to aXridee to traaiCionnl aaetale.--N. L O. 133394. KARIMOV, A. M. Prtoexliooxrny* xxbolrraatrx ntoto w ttlopfeorahov, vyavanwyo yadokhltoBPtnaal, I meroprlyatlya po to pofllitolke. tOecuoalkeml ekla toeeueee In cotton proven 1 chemical wlaon* and measure* tar their m-TT*loo./ cJc : M8gL" TWUrood. OTip-PCSmo and ecm. occurfed in 30 parson* out to 33 to dtooct eootact with DOT and I chlorxne. The dtoturbu*;** wera to a seasonal meun. OtCBcmtoa grower*, lh* skto wa* aunalttve to the pwibaxpifc toidkto* methylmerciptophoa, octamethyl nd tadypboa to 439u The tow to devolopmeot to aeaaRtetolon to dlllaieid AemlcUa varied and 1 on body reiponae, fonreidrtokn to Ibe toeulci^ work 1 toe ntour* of contact.--N. L. C. 1U1H.. AN, A. ,, V. A. D^ACZEHXO, V. L IVANOV, mto A.F. TAUN. Opyt mrdlkamentoxooi profUaktikd poraheuU atnw Mem prl tatokaomtoll ogueatolkdai maoism ~lvrtor-3\ fExpajeoeeto to a breakdown at aa otoctrto power otxttoo were Moxkatod by to* ham* to "Trlol-3", a compound baaed on trtxylevyW>o*(Cue*, * Z, vRanda B* and phytto waa effective to pmXtg itarnige to 132294. XLBUBKAYA, )L T. Ssategraato ptodoeRonU u 1 prl khroakhextoea voadaiatvO parse aMtadtooprspDtoxa of tecondltv to animate affected to tonale aftacto to mi mKemewe'Itmee.l (HOnBlOfTAgain^na-. 44-____ T____ l*taL-%hlo ret* (49) wHfe drktb portodk otftil cycleo eaoe es- poaodbatoofaaaeotorwtadltooipawtoeaiea* tot mg/1 aad 1 mg/l I kr AlOf 9 time* a wk lor I aemal cycb was disturbed vtb tkmarfai eapaoty tar eonoeploe was WdatltUr--------Dumber toeO*{Xla( defiesned aa vwll as their < efleetn d the r tinffimi are toiUrtood,. Womeaf* to tola compmud Would b* regaMk*d.-ff. L. O. 133397. 9UKXARZVBKATA, 7-IL,L.I. SAVZLTVA. uaA.l. VOROtNIXDVA. Qtaeooto. SanlL. 1WU, Novoslb^ tBSR.) Opytlrt- mewcajya < ewimtapmawl ktololy prl MuonkbeulM We*~--1-- twnfcirto t on - *------ * > - -- - ______ 1 Bg and Bji, glucc#* and To prepnntlouu mt use 1} ptodt wgh chronk polaontng kg beaxewe and ka bomok symptoma to btiMnbagk dktkwk. A hemoutatk etfed was unaaQ to 13- day* to patients with mild symptom* of hemophilia aad si 2-3 to days to those with pronounced martIretxtlorn to dldhiaia. In NAka to (he hsmoatatk eRect, capillary permeability *w the nbrtaabOc aetteky of tha hkmd dacranaa< aad htood congulaam time a^iSadap. Tha mimbtr to amtoro ptodalka tocteaiud atter bwtometo Wtomm bertooM (teaWhoryu farm* ktraawnd, N.L.O, 133393. UtjrKO, N. W. tbmt-Hyk-TaeknL Poatk. Polym. ytom. ToiiiiJeeoidStowduS^WR^WtomtotoWInaaf toe n'<n!m * SpagvaTiluTatia^lagturprnimKtnrd,VimhthokFoea-laan lantkbme .i-rnvo^f aram.odToventtarrn-TtxVwea. 15121-755)0 TOXICOLOGY |V.4. mniinu 7552* KUDRYAVTSEVA. O. F. (I)tfr7li1*iik Ini, M. By*. Ocrup. tiirrrfiiii*k, USSR.) K kharxkterlslike elrhlrnhsrrtlncrafichesklkh ^ 11inirnrnlt utrlnykh khrftnlrhrvkm Inlnhslkstslcl khlorlilym vtnllom. T^-iChincirrisitcs of cletitiwardljysphtc ^iwea is PiUcnU with Tiny) thl^nilf pTm-ntac 1 tlfl TP ZAPOL 14 (Si WTOPKO studies of to mile snd O (rtnslc worker* suffering chronic vinyl chloride oisonlsg revealed cardiovascular dlMurtjsnce* manifested i chzn*e* a rhythm, conductance ud repolarlution processes and an Increase In *yiolic Index. ECC ibta ahnuld be vied to determine the condition or the heirt when evaluating (he degree of vinyl chloride poisoning In a patient.--C. P. 75522. pEHKNOVtCH. A. A.. I. S. PAERMAN, end E. V. GLADKOVA. (Inal. Ind. Hyg. Orcup. Die.. Gorki, USSR.) K voproau ob etsenke I aoetnyanlt'funktstl vneshnegn dykhanlya prl pylevyhh tabolcvanlyakh bronkho. IrftnchnniED apparala. IThe evaluation and elate of Ihc external recoins- turn function In dust-induced disorders of the broncho-pulmonary tTIlm.l GIG TR pA6f ZADAl 14(11): 7-16. 1*76. | Engl..sum.)--The nature and extent of change* In a number of ventilation figure* were depoidest on the decree of rreplralory Incompetence and the form and ata(e of the eontotle proceae In the lungs. The reeulta of 1459`examinations were aub|ected to electronic date processing. The moat apeclfle Indlcee char acterising the dletuibcd external reaplration function were the maximum ' pulmonary ventilation, maximum expiration rate and the at terla! blood Oj aaturation. No concluaive difference* of ventilation figure* In pa tient* with dissimilar form* and stage* of pneumoconloalx could be dlscloeed. The moel aerlni* disorder* of the ventilation function were noted In patient* with pn*wmoeon!o*t* accompanied by clinical mantfestatlfl** if chronic bronchltia.--C. M, M. ISSli, ILIKA, V. A., and T. A. KOCHETXOVA. final- bid. Hjf. OcCup. Die-. Acad. Med. Set. USSR. Moscow, USSR.) Eksperimental'nyl pnevmosktcrvx prl vdykhanll aeroaolel msgnlevotitievykh splaeoe. fExnerimcntsl pneumosclerosis from Inhalation nf rnacnealum-llthlnm alloy TSiSTH p*or ZaKSE 1<U: -. Wo. f&jt. sum:]-- When inhaled. Mg-LI alloya have aa Irritating action on the mocoea of the upper reapiratory tract and pulmonary ttaauc and cause a number of changes In the respiratory organ*. Thrse Include moderate catarrhal tracheitis, bronchitis. Interstitial pneumonia, diffuse scleroet* and em physema of the lungi. The extent of the pathological process bscomss greatcT as the LI proportion tn the alloy Increase*.--C. M. M. 75514. ZHDANEEVA, G. S. O rentgenologtchcsklkh limenenlyikh I leghtkh pri mtoksikiutl karbonll-nikclcm v ostrom t ofdalenaom p-riod-kh. fX-ny chances Is the lung* with nickel carbonyl potsonlnx tn t1-* ute phase knit Inter. 1 KAZAK MED ZH 1. 47-50. 1970. Translate! . om REP !h otd Wp PARMAKOL KHIMIOTER SRED6TVA TOKSQCOL, 1970. No. 7,54.749.--to 5 men and 1 women (of whom ( were 11-31 yr old and 1. SZ) who had undergone acute poisoning from IrhaUng nickel carbonyl, observations were made of the organs of 11) thorax for 7-13 yr. Co Ihc 2nd or 3rd day after the poisoning, s high position of the dtapnragm was noted The respiratory movement* of the diaphragm were oof determined or were limited. There wan nheef air content of the pulmonary field. Two patients showed Intensification and vagus*nest id the lung picture and of the roots of lb* lungs and tbs remainder also showed bilateral foci. Retrograde development of tbo A-ray change* began on the 7tb-I2th day*. The outcome of the poisoning was favorabl* In all the young people. Dynamic obsemtlona for 10-13 yr (bowed thal they were completely recovered. Regression of lb* X-ray changes la the older patient was acted until Ifce 29th day. The position and reapiratory movement* of the diaphragm were restored la 3 mo. The picture of the hmg* ud roots became as they originally were la 3 yr after tb* poisoning. After 7 yr the pattest developed pneumosclerosis, cardio sclerosis and stage 1 respiratory Insufficiency. Nickel carbwql potsow ing t* probably not the determining factor la the growth of tbs sclerotic process. It* principal tonic effect ie a disturbance of the tong capil laries sad arteriole*. Acate poisoning la healthy parson* doe* not leave after effect*.--S. T. _ A QJp --- 75521. OSETROVA. V. 1. Soatoyant* tdorov'ya rabochlkb larkha flotoftbrikt Sereinikorskogo kalilnogo kombtnala po danoym periodicbeaktkk mcditsisiklkb oemotrov. iThe health ef workers at the flotation Comenuad plant cf the Bcrezovshll Potass (urni Combine. according to data from periodic physical examination*. I TR PERM MED INST 12: SS-90. 1970. Translated from REF ZH OTD VYP PARMAKOL KHIMIOTER SRED5TVA TOKSDCOL. 1*70, No. 10.S4.757.--Of 137 workers examined 701 were women, SO had worked less thac 10 yr sad 77 more in the flota tion compound plant of the potassium combine. The potentially oecsps- lionally harmful products there consisted of higher aliphatic amines nf fatty acid* it concentration* lens ef limes the maximum allowable with i relative humidly tfmb HI bad temperatere la the plant of up tb 30 C. 17>V patients eomplalned mostly of headache. Of those sesmtsod. 501 showed moderate tachycardia, dulling of heart lone*, labile Mood p. nsurt and fimetlonal CHS disorders. Tenderness In tb* right sub- t*l area m noted In IS patient* and urobilin was fmmd la ths urine lost of those examined. Equipment operator* exposed most to uataes showed ha increase la the cumber of rettcutoeyta* sad thrombocytopenia. -t-T. 75521. MOZAH. C, A. LACtJlMH/Tl. sad I- PETTTHATl. On Mr*. Lav.. Turin, Italy.) Evaluation du risque todoll par lr loseysw-v u^. Iritis, ftviluatlnn nf the hartani* ernatrd be Inrfuvlriil txsiwv 1 ran MAL PROfRED'TOV ice fc' >!(: Ul-UC tTii.-'KTmrm. of cvatuatlng the atnmrpherle harnrd created by Industrial limans that, are currently practiced appear to be unsauafactnry and qw * erttg Results obtained with them are InadmitsMe. The problem nf mrn tug systems of sampling and qeanlltailrr drlermlnaiion f Innas it i sing and essential. Well-defined norms ehould be givte regarding tw epeed of air sampling and ihe point or pnt*<t where nnpiic it to hr done, bi evaluating the risk Involved, Ihe phenomenon eg tnxne lunm. lion upon dlffcrenl surfaces of work areas which become IO-- lary source* of pollution muet not be fnrgulten. The only system aqipeanm to show this part of ths hazard Is that nf quantitative ftunrnsaiinw m series, even at limes when Ihe epeelfle risk 1* theoretically **11. m. that characteristic profiles for each work cycle can be dtiMd. Era la this case, a standard method should be seed in oblate mepariMt reproducible evaluation*. Thl* I* the only way to ubtai* valid param eters id Ihe hazard created by atmospheric toxins. These parameters are essential for a program of organized and syetematie prewatra. --S. L. R_ 75527. nun. TAMOTSU. (Osaka Unlv. Med. Sch,, Osaka. Jap.) (Pm-- moron!osl* caused by "Sendo* dust amarg rush-mat worksrx-1 notOT aUtA RADkJL m. tti-114. illusTfFM. |in7ap."wah`fc^L *ra.)~ Fhacy mil worker* are caponed to dense dust of "seoCb* (a >0(1 id dm used to dye tush) Is tb* process of rush-mat manufacturing. to order to confirm the possibility of the development of pneuimocsaias** dm to "sendo". mss* survey of wo-kers In domestic rush-mat workshops a performed by direct cbesl roentgenography- PucumocmdoUc sodeia found la lb* roentgenograms were not tedform In six*. 15m ill nk n were mainly composed of punettfon* Oiaxllle* from C.S-l.O ms to *- ameler and were distributed evenly thni^liout the lung fielM. Bra td the smalls*** or Individual dust focus, spam* opacities is zw early stag* of pneumoconiosis were difficult to dcmoRitrat* Is roMtoc X-ray film. More pneumocontotic nodules were usually evidenced is the dines 1-fold magnificatto* radiograms than Is csavenfional fibs*. These Ikd lory z**r* similar 10 (boss of some sort* ef atypical stUcosta sod ww-- oonill.cocto pneumoconioses, especially pneumoconiosis caned by rtq (hast initiation. fibrous Ihkkeslsg of the pleura do* to ................chub wks not .-cmrrkabt*. Hilar ebadow* showed no enlargsmisf. - emphysca:* was sot so cosaplcwous. A* to tbs complkaciows m' tto ^g, case* with active pulmooary tuberculosis war* not sevs. Cd 7 siaSazs with dlsllact pneumoconiosis. IT had sllgMIp Impaired hog hsctlm and had moderate impairment. PneumnwcoaloGc workeia ShonMhe removed from area* of Ugh dust exposers to protect toeas from 0* de velopment ef the disease. "AXashl Sentoe" wkteh are mod ha Otsyara Prefecture, are composed of about 30% quart* and many klads <d t minerals. The pneumoconiosis due to "sendo'* Is e son of axypical| tit caused by the dust which contains free silica la low percentage! at the tame time, may be Included In clay po*umoconiasts.~C. M. if 75533. IL'INA, V. A. (fast. IntL Kyg. Oect^. Die.. USER. Moscow, USSR.) Voprosy gigieey truda pel palsthinll t magnlevotUievykh splavov. fOccupations! hveien* In rdexiirtmc and tee of maxneslum-lltMum altSa.l Alfa 5AHTT SSIlbg 34-27. If lEngl. sum.|--Workli^ condlltons at Ibc apes pit mlntog of are characterized by lbs almost coaUsnsas formation of ** Its discharge Into the air of J<* working son*. Tb* aerosol phase consists mainly cf lithium oxide, Mblsst earbossfs. Wlum rid*, lithium fluoride had magnesium aside. The mais sign eg Ow effect or Mg-Ll alloy aerosol* 1* tbo dmlipmint of *s Mia co*s la ths respiratory Met and lbs Img Usewes: uschvltks. and loterxiillal pneumonia nestling Is diffused pnsumnsrteumls mi hmg emphyssmt.--C. M. M. 7553*. BATOLSCA. An aad H. MARSDYA. (but. MxL Pxxg. W. Tm. Trav., SMta. Bulg.) Modifications du gbdilMnti chex Its tTMilllemi d*uns e*(reprise SMtallurgiqs* mlelcrc. fClotalhlone mndlWrattom to workers of a mlntog metallurgical flrm.1 AftfcH MAL PRO# kED tblT stcSOC 51(3h UT-i22. fltus. i70.-A moderaie ctMcal ptetmv mffeating preliminary occupational potoostog was noted bt wnte* m iq contact with Pb. As, Cd and . Almostof the wother* bad loecred Hb. Glutathione (Gat] amounts decreased. GSH IMitoMoa was psrtlM to the length cf lime when contact with the substances occsevwd. The d- feet cf glstatlol was fhvorablt with regard to both the cbslcmi pictare and laboratory tsots. PoHowiag admltosMtloo of tldsisL GSH cnmrm tratloa, tb* reduced GSH/toul GSR rstto and the amoMt d scrum bos dshydrogenas* increased---t- L. R. 0b7t5f5ft5o0t.tvAaSoHslBl EULc*b. eLnLty.aLbGol'.sKykHb ItLllb*u.LaoUmTaAeXroUoBly. atoaddLIDct.skTOlisUsmDwTA. solysial sbcbelochoi. libs effecMvetwad ef Ircaltnc i With aerosol* and slsetroaeraaols ef lbaUes.l SB1 WST GIG TR PftofcABOL Cftlll SJ4 ll lt-154-1370.7 from REF ZH OTD VYP PARMAKOL, KKDrOTER SRETBTTA TOKEXOL. 1970, No. 1.54.W4.--Of 53 silicosis psilmls *tadled. 13. of atom. 12 Sait chronic bronchltld. were trsalsd with a 10% solution of sodhms klrsrt n at* (9 ml by lefulstbsi at pff I far a ecu** of 3 bihsMtbuc a <toy lor to R&S 028238