Document 998my9G80Gjv1QYz3kYmo68aR

R&WI 38440 'reviews 77-83/dan BA7502;RRM2402(See Flle55) (c. 81 OS IS 1982 ) (Item 3 10 of 858 ) User 3614 25jan83 2086 70006582 NONNEOPLASTIC EFFECTS OF VINYL CHLORIDE IN HOUSE LUNG SUZUKI Y ENVIRON. SCI. LAB.. DEP. COMMUNITY MED., MT. SINAI SCU. MED., CITY UNIV. N.Y., ONE GUSTAVE LEVY PL.. NEW YORK. N.Y. 10029. USA. ENVIRON RES 21 (1). 1980.. 235-253. Language: ENGLISH Coden: ENVRA In a previous study. a high Incidence of pulmonary tumors {a 1veo1ogen1c neoplasia) In mouse lung exposed to vinyl chloride at heavy dose (2500 and 6000 ppm) for long durations (5 and 6 mo.) was reported (Y. Suzuki). In the present study, nonneoplast1c effects In mouse lung were Investigated by 1Ight microscopy and EM. As major light microscopic alterations, pro 11fera11 on and hypertrophy of the terminal bronchlolar cells, consisting of ciliated and Clara cells. hypersecretion of the epithelial mucin In the goblet cells of both the bronchial and the proximal bronchlolar epithelium, hyperplasia of alveolar epithelium, mobilization of alveolar macrophages and occasional presence of peribronchial or bronchlolar chronic Inflammation, were observed. Electron mIcroscop1cn11y. Clara cells of the terminal bronchlolar eptthollum showed pro 1 Iforat1 on of tho rough and smooth surfaced endoplasmic rotlculum and appearance of large and abnormally shaped mitochondria. Similar alterations were found In the ciliated cells. SubmIcroscoptc changes of pulmonary alveoli were represented by focal thickening of the basement membrane, multiple foci of hyperplastic type II cell (the precondition of the alveologenlc tumor), active discharge of osrolophillc lamellar bodies from the type II cell and phagocytosis of the bodies by macrophages, appearance of cholesterol crystalloids In the macrophages, degeneration of alveolar septal cells and occasional appearance of a large nucleus with swelling of the capl1lary endothellum. Descriptors: MACROPHAGE CILIATED CELLS CLARA CELLS CARCINOGEN INFLAMMATION LIGHT MICROSCOPY ELECTRON MICROSCOPY Concept Codes: MICROSCOPY-HISTOL.HISTOCHCM TECH(01056); ELECTRON MICROSCOPY(01058); CYTOLOGY/CYTOCHEM-ANIMAL(*02506>; BIOCHEM STUD-GENERAL(10060): BI0PHYS-MEMBRANE PHENOMENA(10508) ; ANATOMY/HISTOL-MICRO,ULTRAMICRSC( 1 1 108 ) : PATHOLOGY-INFLAMMA- TN.1NFLAM DIS(t2508); METABOLISM-GENL STU0.META8 PATHW(13002): BLOOD/BODY FLDS-8LD,LYM.RES PATH(* 15006): BLOOD/BODY FLOS-LYMPHAT TISS.RES{ 15008): RESPIRATORY SYST-GENL STUD.METHS( 16001): RESPIRATORY SYST-PATHOLOGY(*16006); TOXICOL-GENL/EXP STUDS.METHS(*22501): T0X1COL-ENVIRONMNTL.I NO - USTR{22506); NEOPLSMS/NEOPL AGNTS-CARCIN0GEN5(*24007): ENVIRON HEALTH-AIR,WATR.SL P0LLN(37015) BlosystematIc Codes: MURIQAE(86375) Language: ENGLISH The permeability coefficient of benzene vapor In air was calculated from experimentally measured values of solubility coefficient and diffusion coefficient for natural rubber, nitrile, neoprene, natural rubber plus neoprene, butyl rubber , polyvinyl chloride and polyethylene membranes. The permeability coefficient for natural rubber at room temperature (.apprx. 23.degree. C) was 4.2 .times, 10-10 cm2/s when the concentratI on of benzene In air was 10 ppm. This means that a worker (1.8 m2 surface area) completely clothed In a 0.0254 cm (10 mil) natural rubber suit would be exposed via the skin to 0.3 .mu.g benzene In an 8 h shift If the benzene concentration were lO ppm. In the same time period and with the same benzene concentrat1 on the worker would Inhale 1600 .mu.g benzene If his tidal volume were 700 cm3. his breathing rate were 15/mln, and he was wearing a respirator with a protect1 on factor of lOO. Permeability coefficients for other vapor-membrane systems available In the literature suggest that exposure to vapors ponetrnt tng protective garments are In general negligible when compared with Inhalation exposures for low vapor concentrations. Descriptors: SKIN RUBBER NITRILE NEOPRENE BUTYL RUBBER POLY VINYL CHLORIDE POLY ETHYLENE INHALATION Concept Codes: MATHEMATIC B1DL/STATISTIC METH(04500); SOCIAL BIOL/HUMAN COLOGY(05500) 1 BIOCHEM-GASES( 10012); BIOCHEM STUD-GENERAL( 10060): METABOLISM-GENL STUD.ME TAB PATHW( 13002); RESPIRATORY SYST-GENL STUD.METHS{16001): INTEGUMENT SYST-GENL STUDS,METHS( 1850 1 ); ROUTES OF IMMUNIZ.INFECT.THEflAP(22lOO ) : TOXI COL-ANT I DOTES.PREVENT IVE(*22505) ; TOXICOL-ENVIRONMNTL,INDUSTR(* 22506); TEMPERATURE-GENL,METHSt23001); ENVIRON HEALTH-OCCUPATNL HEALTHt*37013); ENVIRON HEALTH-AIR,WATR.SL POLLN(* 37015) B losystematIc Codes: HOMIN10AE(86215) 70006370 THE PERMEABILITY OF PROTECTIVE CLOTHING MATERIALS TO BENZENE VAPOR SANSONE E B: TEWARI Y B ENVIRON. CONTROL RES. LAB., FREDERICK CANCER RES. CENT., FREDERICK. MO. 21701, USA. AM INO I1YG ASSOC U 41 (3). 1980. 170-174. Coden: AIHAA ri-ev 1 ews. 77-83/Uan BA7502 : RRM24Q2( See FI1e55) (c. BIOSIS 1982) (Item 312 of 858) User 3614 25Jan83 2087 700037 14 VINYL CHLORIDE AND TRI CHLORO ETHYLENE COMPARISON OF ALKYLATING EFFECTS OF METABOLITES AND INDUCTION OF PRE NEOPLASTIC ENZYME DEFICIENCIES IN RAT LIVER .LAIS R U; STOECKLE G; BOLT H M; KUNZ W INST. T0X1K0L.. UNIV. TUEQ.. WILHELMSTR. 74, Dt7400 TUEBINGEN, W. GER. J CANCER RES CLIN ONCOL 94 (2). 1979. 139-148. Coden: JCROD Language: ENGLISH [1.2-14C] Vinyl chloride and [1.2-14C] trichloroethylene were Incubated with rat liver mlcrosomes, NAOPH and RNA (from yeast). Whereas tr1ch1oroothy1ene metabolites were Irreversibly bound to proteins In microsomal Incubations to a higher extent than vinyl chloride metabolites. Irreversible binding to RNA was lower for tr1ch1oroethy1ene motabolItes. Hydrolysis of the RNA which was relsolated from microsomal Incubations with 14C~v1nyl chloride or 14C-trIch1oroethy1eno and separation of the nucleosides showed different alkylation products arising from vinyl chloride and from trichloroethylene, characteristic for vinyl chloride being formation of 1.N6-ethenoadenos1ne and 3.N4-ethenocytIdIne. The different reactivities of metabolites of vinyl chloride and of trichloroethylene prompted a comparison of the oncogenic effects of both compounds against the rat liver cell. Newborn rats were exposed for 10 wk to 2000 ppm vinyl chloride or trIchloroethylene (8 h/day; 5 days/wk). After this period livers of the animals were stained for nuc1eosIde-5-tr1 phosph atase. Whereas the vinyl ch1 or 1de-exposed rats showed focal hepatocellular deficiencies in this enzymo. which are supposed to represent an early sign of malignancy, no such changes were Induced by trichloroethylene exposure. The data suggest differences between the hepatocarc1 nogen Ic activity of vinyl chloride and possible effects of trichloroethylene on the 1 Ivor, Oescrtptors: YEAST RNA CARCINOGEN NUCLEOSIDE 5 TRI PHOSPHATASE Concept Codes: M1CR0SC0PY-CYT0L0G.CYT0CHEM TECH(01054); CYTOLOGY/CYTOCHEM-ANIMAL(02506); RAO I ATI ON B101.-RADTN. I SOTOP TECM(06504); COMPARATIVE BIOCHEM-GENL STUDIES(10010): BIOCHEM STUD-GENERAL( 10060): BIOCHEM STUD-NUCL ACD.PURNS,PYRM( 10062): BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACD( 10064); ENZYMES-GEN.- COMPAR STUD,C0ENZYMS( 10802); ENZYMES-METHODS( 10804): ENZYME 5 - - PHYSIOLOGICAL STUDIES(* 10008): METABOLISM-GENL STUD,ME T AB PATHW(* 13002): METABOLISM-PROTNS.PEPTDS.AM ACDS( 13012); METABOLISM-NUCL ACD.PUR I NS,PYRIM(13014); DIGESTIVE SYST-PATHO- L0GY(* 14006); TOXICOL-GENL/EXP STUDS.METHS(*22501); NEOPLSMS/- NEOPL AGNTS-CARCINOGENS(*24007); PEDIATRICS(25000); TISS CULTURE-APPARAT.METHS.MEDIA(325O0); IN VITRO STUDS-CELLULR.SU BCELL ( 32600 ) ; PLANT PHYSIOL-CHEM CONS T I TUF.NT S ( 5 15 2 2 ) Blosystemat Ic Codes: FUNG I-UNSPECIFI ED( 15000); MUR I DAE(8637- 5) MOEED A; DAWSON D G ECOL. DIV., DEP. SCI. IND. RES., PRIV. BAG. LOWER 1IUTT, N.Z. N Z J ZOOL NZJZA 6 (4). 1979 (RECD. 1980). 613-618. Codon: Language: ENGLISH The reproductive success of starlings (S. vulgaris) using nest boxes In Hawke's Bay, New Zealand, differed significantly according to the type of box, but this may refect the competence of the parents as well as the quality of the site. The most young fledged from boxes of 310 cm2 Internal basal area, significantly fewer from boxes of 520 cm2 or more, and Insignificantly fewer from boxes of 180 cm2. Success Increased with the depth of the nest box up to at least 200 mm. Sites with largo entrance holes were little used, suggesting that starlings prefer minimal access clearance (perhaps to exclude predators) and the nest bowl to be dark. The box material (wood, concrete or PVC (polyvinyl chloride)) had no significant effect on use or success. Descriptors: HAWKES BAY NEW-ZEALAND WOOD CONCRETE POLY VINYL CHLORIDE YOUNG SUCCESS DEPTH ENTRANCE HOLE SIZE PREDATORS Concept Codes: GENERAL FIELO METH0DS(O1OO8); GENERAL FIELD APPARATUSf*01010); MATHEMATIC BIOL/ST AT 1 ST IC METH(04500); ECOLOGY-ANIMAL(*07508); EXTERN EFF-LIGHT.DARKNES5( 10604 ) ; REPRODUCT SYST-GENL STUDS.METHS(* 16501): PED I ATRICS(25000): DEVELOPMNTL BIOL-GEN M0RPHGENSIS(*25508 ) : SOIL SCI-GENL STUDS.METHS(52801) Blosystemat1c Codes: SPERMATOPHYTA-UNSPECIFI ED(25000): ANIMAL I A-UNSPECIFI ED(33000); PASSER I FORMES(8554 8 ) 70001360 BREEDING OF STARLINGS STURNUS-VULGARIS IN NEST BOXES OF DIALOG e5: BIOSIS Previews 77-83/Uan BA7502;RRM2402(See FI1 70001322 R&S 138442 EFFECT OF COEXij.*,,-.......... ........ ... SPORICIDAL ACTIVITY OF GASEOUS PROPYLENE OXIDE TOWARD BACILLUS-SUUTILIS-VAR-NIGER TAWARATANI T; INUI Y; SHIBASAKI I OEP. FERMENT. TECHNOl.. FAC. ENG., OSAKA UNIV., YAMAOA, SUITA. OSAKA 565, JPN. HAKKOKOGAKU KAISHI 58 (1). 1980. 1-9. Coden: HKOKD Language: JAPANESE This paper describes the mechanism of the protective action of coexisting substances. I.e., milk casein, agar powder, cellulose powder, polyvinyl chloride powder, teflon powder and glass beads, against the sporlcldal activity of gaseous propylene oxide (PO) toward B. subtil Is var. niger 4380 spores. . The first 4 substances showed remarkable protective action. while the others had no effect. The isothermal PO adsorption curve of spores was of the Henry's type. so the D [decimal reduction time] value of spores was dependent on the amount of adsorbed PO. But the amount of PO adsorbed by spores decreased with increasing water content of spores. When spores were exposed to gaseous PO, the amount of PO adsorbed by spores was significantly decreased In the presence of coexisting protective substances. Although spores lost the water during the gaseous PO treatment. loss of water from spores was suppressed by the coexistence of protective substances. The protective effect of the gaseous treatment. Descriptors: MILK CASEIN AGAR POWDER CELLULOSE POWDER POLY VINYL CHLORIDE POWDER TEFLON POWDER GLASS BEAD Concept Codes: BIOCIIEM-PHYSIOLOGL WATER 5TUD( 10011): BI0C.HEM STUD-GENERAL(10060); BIOCHEM STUD-PROTEINS.PEPTIDES,AMINO ACD(10064); BIOCHEM STUD-CARBOHYDR.( 10068);. BACTERI A-M0RPH0L0- GY.CYTOLOGY(30500): BACTERIA-PHYSI0L0GY,BI0CHEMISTRY(*31000); 01SINFECTION.DISINFECTANTS.STERL(*39500) Blosystemat tc Codes: BACILLACEAE(05610) 69079706 MUTAGENICITY OF PLATINUM COORDINATION COMPLEXES IN SALMONELLA-TYPHIMURIUM BECK D U; FISCH d E OEP. BIOL. SCI., BOWLING GREEN STATE UNIV., BOWLING GREEN. OHIO 43403, USA. MUTAT RES 77 (1). I960. 45-54. Coden: MUREA Language: ENGLISH The mutagenic properties of 5 Pt compounds [antitumor drugs] were studied using Ames p1 ate-IncorporatI on mutngcnosls assays and strains of Salmonella typhlmurlum. Platinum drugs were direct mutagens as thalr mutagenicity was not dependent on metabolic activation by rat liver extracts. Ability of the compounds to revert a base-pair substitution mutation causing histidine dependency wa3 promoted by pi asm Id-mnd I ated DNA-repnlr since cells of strain TA 100 were reverted and not colls of strain TA 1525; those strains are Isogenic except that TA 1525 lacks thepKMIOl plasmid. Mutagenic potencies (revertants per .mu.g compound). as determined from linear dose-response curves, were In order of decreasing mutagenicities; 450. c1s-d1amm1 nod 1chIornplatInum(I I) (cls-platln); 100. dI chi oroethy 1encd1 am Inep1 atInum(1 I); 90. (c. BIOSIS 1982 ) (Item 314 of 858) User 36 14 25J.V 2088 d 1 amm tnema1ona top 1 a11num(II); 60. dlammlneoxalatoplatlnum(Ii); and 16 , t rans - d 1 amm 1 nod I ch 1 or op loti num (II). rramoshift mutations were not reverted In treated colls of strains IA 98. TA 1537 or TA 1538. Compounds which reacted with the most active mutagen, cls-platln, such as pantoyl lactone. adonlno or cytldlne. caused a decrease In number of revertants when added with the drug to pints-Incorporation assays. The effect of methionine on mutagenicity of cls-platln was exceptional In that prelncubatI on of methionine and cls-platln was required for decreasing Its mutagenic activities. When methionine and cls-platln were added concomitantly to assays there was an elevation of Its mutagenicity. Methionine may enhance mutagenicity of the platinum drug by Increasing activities of some enzymes associated with error-prone DNA repair. Descriptors: TA-98 TA-100 TA-1535 TA-1537 TA-1538 STRAINS PLASMID PKM-101 RAT LIVER METABOLIC ACTIVATION CIS DI AMMINE DI CIILORO PLATINUM II 01- CHLOROETHYLENE DI AMINE PLATINUM II DI AMMINE MALONATO PLATINUM II DI AMMINE OXALATO PLATINUM I I TRANS DI AMMINE 01 CHLORO PLATINUM II ANT INEOPLAST IC-DRUG DNA METHIONINE PHARMACODYNAMICS FRAMESHIFT SUBSTITUTION BASE PAIR SUBSTITUTION PANTOYL LACTONE ADENINE CYTIOINE ERROR PRONE DNA REPAIR ENZYME Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(*02506): GENETICS/C- YTOGENET-ANIMAL(*03506); BIOCHEM STUD-NUCL ACO,PURNS.PYRM(lOO- 62): BIOCHEM STUO-PROTEINS.PEPTIDES.AMI NO ACO(IOOG4): MINERALS( 10069); ENZYMES-PHYSIOLOGICAL STUD IES( * 10808); METAn0LISM~PR0TNS.PEPTD5.AM ACDS( 13012); METABOLISM-NUCL ACD.PUR INS,PYRIM( *13014); DIGESTIVE SYST-PHYSIOL.BI0CHEM( 14 00- 4); PHARMACOL-DRUG METAB.METAB ST IMU(22003); TOXI COL - PHARMAC OLOGICAL (*22504); NEOPLSMS/NEOPL AGNTS-TKERAP,AGNT(* 24008): BACTERIAL AND VIRAL GENETICS(31500); MICROBIOLOG APPARAT,METHS.MOIA(32000): CHEMOTHERAPY-GEN STUD.METH.METAB(- 38502) B losystematIc Codes: ENTEROBACTERIACEAE(04810); MURIDAC(863- 75) DIALOG F 1 1 e5 ; BIOSIS Pi R&$ 138443 ;RRM2402(See F I I e55 ) (c. BIOSIS 19B2) (Item 316 of 858) user 3614 25jan83 2089 6907284 5 A GAS CHROMATOGRAPHIC HEAD SPACE METHOD FOR MONITORING VINYL CHLORIDE IN LIQUID DRUG AND COSMETIC PRODUCTS WATSON J R; LAWRENCE R C; LOVERING E G PHARM. CHEM. DIV., DRUG RES. LAB., HEALTH PROT. BRANCH. OTTAWA, ONT. KIA 0L2, CAN. CAN J PHARM SCI 14 (3). 1979. 57-60, Coden: CNJPA Language: ENGLISH A gas chromatographic method Is described for monitoring vinyl chloride (a carcinogen] levels In liquid drug and cosmetic preparations packaged In polyvinyl chloride containers. A weighed aliquot of the commercial product In a tightly septum-sealed vial with accurately known headspace volume Is heated to 50.degree. for 30 min. A portion of the warm headspace gas Is then Injected Into a gas chromatograph equipped with a flame Ionization detector and a styrene-d1v1ny1 benzene porous polymer column. The vinyl chloride Is eluted Isothermally at 125.degree. and Is quantitated by simple computation relative to a response factor determined dally using a standard vinyl chlorlde-oir calibration gas mixture. The procedure was subjected to collaborative study by 5 analysts. Two mouthwash products, 2 commercial shampoos, 2 largo volume parenteral solutions and 2 baby oil preparations were analyzed. Statistical evaluation of the results of tho study showed that the method had an overall coefficient of variation of about 17%. The limit of detectability of the procedure Is about 0.1 ppb In the sample solutIon. Descriptors: CARCINOGEN SOLUTION BABY OIL MOUTHWASH SHAMPOO PARENTERAL Concept Codes: MATHEMATIC BIOL/STATISTIC METH(04500); BIOCHEM METH-GENERAL( * 10050); BIOCHEM STUD-GENERAL(10060); BIOPHYS-GENERAL BIOPHYS TECH( 10504); EXTERN EFF-HOT( 10618); MOVEMENT(12lOO); DENTAL/ORAL B10L-GENL STUD.METHS(19001): PHARMACOL-GENERAL STUD IES(22002); TOXICOL-GENL/EXP STUDS.ME TH- S('22 501 ): TOXICOL-PHARMACOLOG I CAL(+22 504 ) ; TEMPERATURE-GENL,- METHS(2300 I ); NE0PL5MS/NE0PL AGNTS-CARCI NOGENS('24007) 69069687 IN-VIVO EVALUATION OF ARTIFICIAL SURFACES WITH A NONHUMAN PRIMATE MODEL OF ARTERIAL THROMBOSIS HANSON S R; MARKER L A; RANTER B 0; HOFFMANN A S DIV. HEMATOL., DEP. MED.. HARBORVIEW MED. CENT., 325 9TII AVE.. SEATTLE. WASH. 90104. USA, J LAB CLIN MED 95 (2). 1900. 289-304. Codon: JLCMA Language: ENGLISH Factors determining the thrombotic response to artificial surfaces in vivo were Investigated In a baboon (Paplo cynocepha1 us] cannular shunt modol. Overall rates of thrombus formation In vivo were klnettcally assessed with autologous 5ICr- 1abo1nd blood platelets and 1251-lobelod flbrlnogon. Rates of cannula platelet consumption per unit area (p1 ate1ets/cm2-day) depended strongly on material type yet were Independent of large variations In cannula blood flow rate, circulating platelet concentration and total cannula PViPfpCO -f lrtnnr. I'+nH.--- ... ' grafted acrylic polymers and copolymers there was a direct linear correlation (r [correlation coefficient] * 0.833) between tho water content of the grafted layer and the rate of platelet consumption per unit area. With 5 commercial polyurethanes there was a good Inverse correlation (r * 0.935) between platelet consumption per unit area and the percentage of surface carbon atoms forming C-H bonds ns determined by ESCA [electron spectroscopy for chemical analysis]. Po1ytetraf1uoroethy1ene, polyvinyl chloride, po1 ydimethy1s1 Io- xane and polyethylene consumed less than 2 .times. 100 p 1 ateIcts/cm2 per day and were the least consumptive materials tested. In 5 experiments with consumptive shunts. heparin antIcoagu1 at 1 on did not alter sIgn1fI cant 1y the rate of platelet consumption (P > 0.80) compared to 7 control studies without heparin. Platelets taken from donor animals with consumptive shunts survived normally In recipient animals without shunts. demonstrating that the residual lifespan of circulating platelets was not reduced. Consumptive shunts positioned In the renal arteries of 3 animals caused progressive occlusion of the renal microcirculation by platelet emboli. In simultaneous control studies utilizing Silastic cannulas In the opposing kidneys, emboli could rarely bo detected. Platelet consumption Induced by artificial surfaces results In tho production of platelet mlcroomholt. This process strongly depends on the physicochemical properties of prosthetic materials. Descriptors: PAP 10-CYNOCEPHALUS PLATELET HEPARIN ANTICOAGULANT HEMATOLOGIC-DRUG PLATELET EMBOLUS RENAL MICRO CIRCULATION OCCLUSION POLY ETHYLENE POLY 01 METHYL SILOXANE POLY VINYL CHLORIDE POLY TETRA FLUORO ETHYLENE FIBRINOGEN SILASTIC Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506): RADIATION BIOL-RADTN.ISOTOP TECH(O6504): BIOCHEM METH-GENERAL( 10050 ) : BIOCHEM METH-PROTNS.PEPTDS.AM AC( 10054); BIOCHEM STUO-GENERAL- (100G0); BIOCHEM STUD-PROTEIN5.PEPTIDES.AM I NO ACD(I00G4); BIOCHEM STUD-CARBOHYDR.(10068); BIOPHYS-GENERAL BIOPHYS TECH( 10504); BIOPHYS-MOLECUL PROP,MACROMOLEC( 10506 ) ; BIOPHYS-- BIOENGINEERING(*10511); ANATOMY/HISTOL-MICRO.ULTRAMICRSC(11108); MOVEMENT(12100); MET ABOLISM - PROTNS,pEPTDS.AM ACDS( 13012); CARDIOVASC SY5T-GENL STUDS.METHS('14501); CARDIOVASC SYST-BLO VESS PATHOL( 1 4508 ) ; BLOOD/BODY FLDS-GENL STUDS,METHS( I 5001 ) ; BLOOD/BODY FLDS-BLOOD.LYMPH STUD('15002 ) ; BLOOD/BODY FLDS-8L000 CELL STUDS(* 15004); URIN SYST/EXT SECR-PA IHOLOGY( 1 5506 ) ; PHARMACOL-BLOOD,HEMATO AGENTS(22008) Btosystematic Codes; PR I MATES-UNSPEC1FI ED(86190); CERCOPITII- ECI DAE(B6205) DIALOG F11e5: BI05IS Previews R&S 138444 2( See F11e55 ) (c. BI0S1S 1902) (Item 318 of 850) User 3614 25jan03 2090 69069368 BLOOD COMPATIBILITY OF MEDICAL DEVICE MATERIALS AS MEASURED BY LYMPHOCYTE FUNCTION WILSNACK R E; 8ERNADYN S A HUNTINGDON RES. CENT.. DIV. BECTON DICKINSON CO., P.O. BOX 527. BROOKLANOVILLE. MO. 21022, USA. BIOMATER MED DEVICES ARTIF ORGANS 1980). 527 - 5A 6, Codon: BMDOA 7 (A). 1979 (RECD. Language: ENGLISH Bovine lymphocyte compatibility of a variety of device materials was assessed by quantification of effect on PIIA-M (phytohemagglutinin) mediated lymphocyte activation In a whole blood assay. Samples of polypropylene, polyethylene, stainless steel. Teflon. polycarbonate. silicone rubber and somo polyurethane proved 1ymphocompat1b1e. Polyvinyl chloride plastics and rubber yielded the largest proportion of 1ymphosuppress1ve samples. Lymphocyte Inactivation manifested character 1stles suggestive of specific receptor alteration, demonstrated typical dose response kinetics and proved a more sensitive Indicator of specific aspects of blood compatab I 1 Ity than hemolysis. Most 1ymphosuppressIve materials failed to Induce hemolysis under the defined test parameters. Descriptors: BOVINE LYMPI10 SUPPRESSION HEMOLYSIS PIIYTO HEM AGGLUTININ RUBBER POLY VINYL CHLORIDE POLY URETHANE POLY PROPYLENE POLY ETHYLENE STAINLESS STEEL TEFLON POLY CARBONATE SILICONE RUBBER Concept Codes: CYT0L0GY/CYT0CHEM-ANIMAL(O2506); BIOCHEM STUD-GENERAL(10060); BIOCHEM 5TU0-PR0TEI NS,PEPTIDES.AMI NO ACD(10064): BIOPHYS-BIOENGINEERING(* 10511): BLOOD/BODY FLDS-BLOOD.LYMPH STUD(15002); BLOOO/BOOY FLOS-BLOOO CELL STUDS( + 1500A); BLOOO/BODY FLDS-LYMPHAT TISS.RES(* 15008); PHARMACOL-BLOOD.HEMATO AGENTS(2200B); PHARMACOL - IMMUNO PROCES .ALl. ERGY ( 22018 ) ; IMMIJNOL/I MMUNOCHEM- IMMUNOP A TIIOL ( *34508 ) ; PLANT PHYSIOL-CHEM CONST ITUENTS(5 I 522); PHARMACOGNOSY/PHARM- ACEUT BOTANY(54000) Blosystemat1c Codes: PLANTAE-UNSPECIFI ED( 11000); B0VIDAE(85- 7 15) 69068020 TOTAL ELEMENTAL CONTENT PASSIVE PERSONAL MONITORS MONTALVO J G JR SOUTH. REG. RES. CENT.. P.O. BOX 19607, NEW ORLEANS. LA. 70179. USA. AM IND HYG ASSOC J 40 (12). 1979. 104G-1054. Codon: AIHAA Language: ENGLISH Tho development of specific passive personal monitors for each volatile form of on element should ultimately load to a common monitor which can detect any or all forms of that elements. Such a device Is a total elemental content passive personal monitor and depends upon diffusion to bring gaseous pollutants Into its collecting matrices. How to compute and limit the ambient concentration error attributed to molecular diffusion approximations for such monitors is shown. The error depends upon the'value for the weighted diffusion coefficient USed to CO Overt tlio Of rO n m r* o + rnl i .. concentration. A computed average diffusion coefficient tends to be non I deal. because the relative conccntratIons of tho volatile forms of an element entering the monitor are variable during the work day. Since it Is not possible to calculate an exact diffusion coefficient, a finite error exists between monitor and ambient concentration values. Total organic Cl at a vinyl chloride plant can be estimated by use of an average diffusion coefficient without Imparting significant error. Descriptors: DIFFUSION GA5E0US POLLUTANTS TOTAL ORGANIC CHLORINE VINYL CHLORIDE Concept Codes: MATHEMATIC BIOL/STAT ISTIC METH(04500 ) ; ECOLOGY-BIOCLIMATOL.BIOMETEOROLf *07 504); BIOCHEM-GASES( 10012); BIOCHEM METH-GENERAL( 10050): BIOCHEM STUD-GENERAL( 10060): MOVEMENT( 12100); TOX I COL-ENV1RONMNTL. INDUSTR(2250G); ENVIRON HEALTH-OCCUPATNL HEALTH(*37013): ENVIRON HEALTH-A IR.WATR.$L PQLLN(*37015) B losystematic Codes: HOMINIDAE(B62 15) 69067933 GASEOUS HYDROGEN SULFIDE DETERMINATION BY DIS COLORATION OF LEAD STABILIZED POLY VINYL CHLORIDE GRAEDEL T E; FRANEY U P BELL LAB.. MURRAY HILL, N.J. 07974. USA. AM IND HYG ASSOC J 40 (11). 1979. 947-954. Coden: AIHAA Language: ENGLISH The discoloration of Pb-stablI lied PVC (polyvinyl chloride) resulting from Its Interaction with H2S gas was Investigated as a potential H2S measurement technique. Color measurements of PVC samples exposed to controlled concentratIons of H25 over a range of humidities and temperatures demonstrated that toxic M2S concentrations can be detected In less than 5 min. The technique was appropriate for industrial applications such as the pretesting of manhole atmospheres prior to entry. Exposure times of several hours were sufficient to detect the much lower 112S concentrations that might be present In ambient e.g.. 15 h exposures were needed for 10 3 ppb H2S. a level typical of certain oil field, swamp and sewage treatment areas. The technique Is Inexpensive and can be performed by unskilled personnel. Descriptors: MANHOLE ENTRY HUMIDITY TEMPERATURE OIL FIELD SWAMP SEWAGE TREATMENT Concept Codes: ECOLOGY-BIOCLIMATOL.BIOMETEOROL(07504); ECOLOGY -LIMNOLOGY(*07514 ); ECOLOGY-WATR RESRCH.FISHERY BI0L(075 I 7): BIOCHEM-GASES(10012); BIOCHEM METH-GENERAL(* 1005 - 0); BIOCHEM STUD-GENERAL(10060): BIOPHYS-GENERAL BIOPHYS TECFK 10504); BIOPHYS-BIOENGINEERING(10511); EXTERN EFF-TEMPER ATURE ( 106 14 ) : EXIFRN Err-HUMIDITY( 10620): TOXI COL-ENV1RONMNTL- . INDIJSTR( *22506) ; TEMPERATURE-GENL,METHS(23001 ) ; ENVIRON IIEAL TH-OCCUPAINL I IEALTl I (* 37013); ENVIRON HFALTH-SCWG 01 SP.SANITAR( *370 14 ); ENVIRON HEALTH-A IR.WATR.SL POLLN(* 37015) DIALOG g5 : BIOSIS Previews 77-8 R&S 138445 F I1e55 ) (c. BIOSIS 1982) (Item 321 of B5B) User 3614 2SJanB3 209 1 69065887 CARCINOGENICITY OF CHLORO ETHYLENE OXIDE AN ULTIMATE REACTIVE METABOLITE OF VINYL CHLORIOE AND BIS CHLOROMETHYL ETHER AFTER SUB CUTANEOUS ADMINISTRATION AND IN INITIATION PROMOTION EXPERIMENTS IN MICE ZAJDELA F; CROISY A; BARB IN A; MALAVEILLE C: TOMATIS L: BARTSCH H UNIT CHEM, CARCINOG.. CEDEX 2, FR. 150 COURS ALBERT-THOMAS, 69372 LYON CANCER RES 40 (2). 19B0. 352-356. Coden: CNREA Language: ENGLISH Repeated s.c. administration of ch1oroethy1 one oxidase, a reactive metabolite of the carcinogen vinyl chloride, Induced local tumors In mice, with an Incidence comparable to that of b1s(chioromethy 1)ether, a structurally related human and animal carcinogen, when both compounds were applied at maximum tolerated chronically toxic doses; no tumors distant from the Injection site were ch1oroethy 1ene oxide produced. and Its BIs(ch1oromethy 1)ether. rearrangement product ch1oroaceta 1dehyde, a highly toxic compound. were further tested In an InItI atI on-promo11 on experiment. Application to the skin of .a single dose of bts(chloromethyl)ether or ch1oroethy 1ene oxide, followed by 3-11mes-week 1y applications of 12-,0-n*tetradecanoylphorbol- 13-acetate for 42 wk, produced skin tumors In mice: ch1oroaceta1dehyde under comparable conditions produced no Increase In benign or malignant tumors. A good correlation between the chemical reactivity, on the basts of hydrolysis constants In aqueous media, and the carcinogenicity of the 3 compounds was noted. Apparently epoxldatlon of the ethylenlc double bond In vinyl chloride yields an ultimate carcinogenic metabolite, chioroethy 1ene oxide, a highly reactive compound which also appears to be largely responsible for the known genetic changes caused by the parent 'compound. Descriptors: HUMAN 12-0-N TETRA DECANOYL PHORBOL 13 ACETATE CARCINOGEN CHLORO ACETALDEHYDE Concept Codes: GENETICS/CYTOGENET-ANIMALf *03506); COMPARATI VE BIOCITEM-GENL STUDIES(10010); BIOCHEM STUD-GENERAL(10060); METABOLISM-GENL STUD,METAB PATHW(* 13002); INTEGUMENT SY ST -GENL STUDS.METHS(18501): INTEGUMENT SYST-PATHOLOGY(*18506); ROUTES OF IMMIJNIZ, INFECT ,THERAP(22 lOO) : TOX l COL - C.ENL/EXP STUDS,METHS(*22501); NEOPLSMS/NEOPL AGNTS-CARC I NOGENS(* 24007 ) Blosystemat1c Codes: HOMINIDAE(86215); MURI0AE(86375) hydratase could bo Separated from each liver source. Most of the rat and human preparations were apparently homogeneous as Judged by polyacrylamide gel electrophoresis In the presence of sodium dodecyl sulfate; all of the preparations examined had apparent MW of 50,000 as Judged by this technique. Different epoxide hydratase fractions showed differences upon rochromntography or agarose gel e1ectrophoresIs. Amino acid compositions were determined for all of the apparently homogeneous enzyme preparations: analysis of the data Indicated differences between some of the Isolated proteins. Differences were also found between some of the epoxide hydratase fractions when their activities toward the substrates styrene-7.8-ox Ide. benzo(aIpyrene-4.5-ox 1de. benzo(a)pyrene-7,8-ox Ide, benzo(a)-anthracene-5;6-oxlde. d I be - nzo(a,h)anthracene-5,6-oxide, 3-me thyIcholanthrene - 1 1. 12-oxtdo and 2-ch1oroethy1ene oxide were examined under conditions of fixed time and enzyme and substrate concentrations. Some apparent differences were also observed In the effects of fixed concentrations of metyrapone, cyclohexene oxide and 3,3.3-tr1ch1oropropy1ene oxide on enzymatic activities of the various epoxide hydratase fractions. These oDservatIons, coupled with Immunological studies provide evidence that: rat and human liver microsomal epoxide hydratases are similar to each other in many respects but are distinguishable by several criteria; multiple forms of epoxide hydratase exist In livers of Individual rats or humans: and the natures of these forms and the levels of each can be altered by treatment with various xenoblotlcs. Descriptors: BENZO A PYRENE 7 8 OXIDE STYRENE 7 8 OXIDE BENZO A ANTHRACENE 5 6 OXIDE DI BENZO A PYRENE 7 8 OXIDE BENZO A PYRENE 4 5 OXIDE 3 METHYL CHOLANTHRENE 11 12 OXIDE 2 CHLORO ETHYLENE OXIDE METYRAPONE CYCLO HEXENE 0XI0E 333 TRl CHLORO PROPYLENE OXIDE METABOLIC-DRUG AMINO-ACID COMPOSITION GEL ELECTROPHORESIS IMMUNOCHEMISTRY Concept Codes: COMPARATIVE BIOCHEM-GENL STUD IES(' 10010): BIOCHEM ME Til-PROTNS.PEPTDS.AM AC< 10054); BIOCHEM STUD-GENERAL- (10060); BIOCHEM STUD - PROTEI NS,PEPTIOES.AM I NO ACD( 10064); BIOPHYS-GENERAL BIOPHYS TECH( 10504); EN2YME.S-GEN,COMPAR STUD,COENZYMS( 10802); ENZYMES-METHOOS(* 10804); ENZYMES-CHEM, - PHYSICAL STUDIES(* 10806): MOVEMENT( 12100): METABOLISM-GENL STUD.METAB PATHW( * 13002); DIGESTIVE SYST-PHYSIOL.BIOCHEMf I 40- 04); PHARMACOL-DRUG METAB. METAB S T I MU ( * 2 2003 ) ; TOX I COL - GENl. /E - XP STUDS, METHS1 *22501 ) ; NEOPLSMS/NEOPL AGNTS - C ARC I NOC.ENS ( 2400- 7); IMMUNOL/1MMUNOCI IEM- GEN METH(34502) BlosystematIc Codes: HOMINIDAE(86215): MUR I DAE(86375 ) 69064055 RAT AND HUMAN LIVER MICROSOMAL EPOXIDE HYDRATASE EC-4.2.1.63 PURIFICATION AND EVIDENCE FOR THE EXISTENCE OF MULTIPLE FORMS GUENGERlni F P; WANG P; MITCHELL M B: MASON P S DEP. BIOCHEM., VANDERBILT UNIV. SCH. MED., NASHVILLE. TENN. 37232, USA, 0 BIOL CHEM 254 (23). 1979. 1224B-12254. Coden: vJBCHA Language: ENGLISH Liver microsomal epoxide hydratase was purified from untreated rats, from rats treated with phenobarbIta1. 3-methy1cholanthrene, or trans-st11 bone oxide, and from 3 different human autopsy samples. More than 1 form of epoxide DIALOG FI1e5: BtOSIS Provlows 77 R&S 138446 Sno r 11 69062467 BLOOD SURFACE INTERACTIONS FOURIER TRANSFORM IR STUDIES OF PROTEIN SURFACE ADSORPTION FROM FLOWING BLOOD PLASMA AND SERUM GENOREAU R M: JAKOBSEN R J BATTELLE COLUMBUS LAB.. COLUMBUS, OHIO 4320) . USA. J B10ME0 MATER RES Coden: JBMRB )3 (6). 1979 (RECD. 1980). 893-90G. Language: ENGLISH Adsorption of blood proteins onto various surfaces In contact with flowing (human and rabbit] blood plasma or serum was investigated using Fourier Transform IR spectroscopy (FT -1R) coupled with attenuated total reflection (ATR). Comparison of adsorption from a static versus a flowing blood plasma system Indicated that a greater amount of protein was adsorbed when the static system was employed, but desorption was observed with the static system and not In the flowing system. When plasma and serum were compared In terms of amount and type of protein absorbed, little difference was noted In kinetics of adsorption or stability of the adsorbed layers. Variations In ratios of IR adsorption bands (from plasma or serum) Indicate that changes occur during the adsorption process In the protein layers. Comparison of poly(vlnyl chloride) to germanium as the protein adsorbing surface In the static system showed differences In composition of the adsorbed layers. Descriptors: RABBIT HUMAN Concept Codes: MATHEMATIC .BIOL/STATISTIC METH(04500); RADIATION BIOL-RADTN.ISOTOP TECH(06504); BIOCMEM METH-PROTNS,- PEPTDS,AM AC(10054); BIOCHEM STUD-PROTE1 NS,PEPTIDES,AM1ND ACD( +10064); BIOPHYS-GENERAL STUD IES( 10502); BIOPHYS-GENERAL BIOPHYS TECH( 10504); BIOPHYS-BIOENGINEERING(* 10511): MOVEMENT- (12100); BLOOD/BODY FLDS-GENL STUDS.METHS(15001); BLOOD/BODY FLDS-BLOOD,LYMPH STUD(+15002) BlosystematIc Codes: LEPORIDAE(86040): HOMINIDAE(06215) 69061114 A SELECTIVE GAS CHROMATOGRAPHY COLUMN FOR TRACE ANALYSIS OF VINYL CHLORIDE IN AIR KROCKENBERGER D; LORKOWSKI H; ROHRSCHNEIDER L ZENT. FORSCH. ENTWICK., CHEM. WERKE HUELS AG. PQSTFACH 1320. D-4370 MARL. W. GER. CHROMATOGRAPHIA 12 (12). 1979 (RECD. 19BO). 787-789. Coden: CIIRGB Language: ENGLISH A selective GC [gas chromatography] column for the determination of vinyl chloride monomer In air was developed. The 1.5 m .times. 1/8 In column was filled with a mixture of Porapack S and T (00:20). The selectivity was tested with 21 possible pollutants. All of the tested compounds were separated from vinyl chloride, a potental carcinogen. Descriptors: POLLUTANTS CARCINOGEN Concept codes: ECOLOGY-BIOCLIMATOL.BIOMETEOROL(+07504); BIOCHEM MF.TH-GENERAL( * 10050) : BIOPHYS-GENERAL BIOPHYS TECH( 10504); MOVEMENT( 1210O); TOXI COLtENVIRONMNTL.INDUSTR(* 22 - 506); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(24007); ENVIRON HEALTH-AIR.WATR.SL POLLN(+37015) (c. runsis Iona) i iiph 333 or non) user nr>i4 25)a 30'J ? 69058960 HEPATIC ANGIO SARCOMA ASSOCIATED WITH ANDROGTNIC ANABOLIC STEROIDS FALK H; POPPER H; THOMAS L B; ISHAK K G CHRONIC DIS. DIV.. BUR. EPIDEMIOL.. CENT. DIS. CONTROL. US PUBLIC HEALTH SERV,. ATLANTA. GA. 30333. USA. LANCET 2 (8152). 1979. 1120-1122. Coden: LANCA Language: ENGLISH A retrospectIve epidemiological study of deaths from hepatic angiosarcoma (HAS) In the USA showed that during 1964-1974 there were 168 such cases, of which 37 (22%) were associated with previously known causes (vinyl chloride, thorotrast and Inorganic arsenic) and 4 (3.1%) of the remaining 131 cases with the use of androgep1c-anabo1Ic steroids. The long-term use of androgen 1c-anabo1 Ic steroids Is the 4th cause of HAS, the majority of cases still being of unknown etiology. The presented cases serve as a link In a spectrum of hepatic disorders recently recognized to be caused by envlronmcnt.il agents such as vinyl chloride, arsenic.' and thorotrast and by contraceptive and anabolic steroids. Similar precursor stages, usually not recognized by clinical laboratory tests and consisting of areas of hyperplasia of hepatocytes and sinusoidal cells and sinusoidal dilatation. lead potentially to hepatic adenoma, carcinoma, poliosis and angiosarcoma. Descriptors: HUMAN HEPATIC ADENOMA PEL I OS I S CARC1 NOMA VINYL CHLORIDE THOROTRAST ARSENIC USA Concept Codes: CYTOLOGY/CYTOCHEM-HUMAN(02508); MATHEMATIC BIOL/STATI5TIC METH(04500); BEHAVIOR BIOL-HUMAN BEHAVI OR(0700- 4); CLIN BIOCHEM-GENL STUD IES( 10006); BIOCHEM STUO-GENERAL( 10060): BIOCHEM STUD - STEROLS.STEROIDS( 10067); ANATOMY/HISTOL-MICR0.ULTRAMICRSC(11108): PATHOLOGY-COMPARATIVE(12503); PATHOLOGY-NECROSIS(12510); META BOLISM - STEROLS,STEROI OS(13008); DIGESTIVE SYST-GENL STUDS.ME- THS(14001): DIGESTIVE SYST-PATHOLOGY(*14006): CAROIOVASC SYST-BLD VESS PATHOL( 14508): ENDOCRINE SYST-GONADS.PLACENTA( - + 17006); PSYCHIATRY-ADO ICTI ON(INC SMOKNG)(21004 ); PHARMACOL - E- NDOCRINE SYST(+22016); TOXI COL-GENL/EXP STUDS.METHS( 22501 ); 10X1 COL-PHARMACOLOGICAL(+2 2504 ): TOXICOL-ENVIRONMNTL.INDUSTR(+22506); NEOPLSMS/NEOPL AGNTS-BIO- CHEM(+24006); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS( *24007 ); PUB HEALTH-ADMJNISTR.STAT I ST ICS(37010); ENVIRON HEALTH-AIR.WATR.SL POLLN(37015): EPIDEMIOL-ORGANIC DIS.NEOPLASMS(37054) BIosystematIc Codes: HOMINI 0AE(862 1 5 ) DIALOG Flle5: BIOSIS Previews 77-B3/Jan B/ R&S 138447 ) (c. BIOSIS 1982) (Item 326 of 858) User 3614 25jan83 2093 69055842 IN-VIVO ASSESSMENT IN SHEEP OF THROMBO RESISTANT MATERIALS BY DETERMINATION OF PLATELET SURVIVAL LINDON J N; COLLINS R E C; COE N P; JAGOOA A; BRIER-RUSSELL D; MERRILL E W; SALZMAN E W DEP. SURG., BETH ISR. HOSP., 330 BROOKLINE AVE., BOSTON. MASS, 02215. USA. CIRC RES 46 (1). 1980. 84-90. Language: ENGLISH Coden: CIRUA The thromboresI stance of 13 potentially blood-compatIb1e polymers was assessed In sheep by determining survival of 51Cr- 1abe1ed platelets. Polymer tubing (120-150 cm .times. 2.0-2.3 mm l.d. [Internal diameter]) colled around the neck was incorporated Into the circulation through silicone rubber connectors as a carotid artery-external Jugular vein shunt. The moan platelet half-life In control animals (shunt control) was 78.2 2,8 (SEM [standard error ofthe mean]) h. Of the 13 polymers tested, ,11 significantly shortened platelet half-life [ t 12 ] . Polyvinyl chloride ( t 1 / 2 = 45.4 . . 3.0 h), polyperfluoro ethylene (tl/2 = 47.0 .+-. 1.6 h), and a polymethyl acrylate (PMA)/acr11 on ItrIIe copolymer (t1/2 = 50.7 7.0 h) produced the greatest shortening. Only slllca-freo po 1 yd I mo thy 1 slloxane (tl/2 * 74.7 4.9 h) and PMA (tl/2 = 01.5 .+-. 3.4 h) were Indistinguishable from shunt controls. Pretreatmont of PMA tubing with autologous plasma In a paired trial significantly Increased platelet half-life (P < 0.05 vs. untreated PMA). This system offers an economical, reproducible, sensitive and biologically relevant method for assessment of the reactivity of artificial surfaces with platelets. Descriptors: PLASMA POLY VINYL CHLORIDE POLY PER FLUORO ETHYLENE POLY DI METHYL SILOXANE ACRYLONITRILE CO POLYMER artificial Surface Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506); MATHEMATIC BIOL/STATISTIC METH(04500); RADIATION BIOL-RADTN.I50T0P TECH(06504); COMPARATIVE BIOCHEM-GENL STUD IES( 10010): BIOCHEM STUD-GENERAL( 10060) : MINERALS ( 10069) : BI OPHYS-BIOENC. INE ER I NG ( - * 10511); ANATOMY/HISTOL-EXPERIMENTAL( 1 I 104); CARDIOVASC SYST-GENL STUDS.METHS(14501); CARDIOVASC SYST-BLD VESS PATHOLC 14508 ) ; BLOOD/BODY F LDS - BLOOD . LYMPH S'TUO ( * 15002 ) ; BLOOD/BOOY FLDS-BLOOD CELL STUDS(*15004) B losystematIc Codes: BOVIDAE(85715) separated vinyl chloride from 65 potential Interfering substances like low-bolling hydrocarbons and halogenated hydrocarbons. Descriptors: CARCINOGEN INTERFERING SUBSTANCES Concept Codes: ECOLOGY-BIOCLIMATOL.BIOMETEOROL(07504 ) ; BIOCHEM METH-GENERAL(* 10050): BIOCHEM STUD-GENERAL( 10060) : MINERALS!10069): BIOPHYS-GENERAL BIOPHYS TECH(10504): MOVEMENT( 12 100): TOXI COL -ENVIRONMNTL, INDUSTR(*22506 ) ; NEOPLSM- S/NEOPL AGNTS-CARC I NOGENS(* 24007): ENVI RON HEALTH-A IR.WATR.SL POLLN(*37015) I 69053996 A DIRECT AND SENSITIVE GAS CHROMATOGRAPHIC METHOD FOR SELECTIVE MEASUREMENT OF VINYL CHLORIDE IN AMBIENT AIR BURGIIARD [ E; J E L T E 5 R; VAN DE WIEL H d; ORANdF E .J TNO RES. INST. ENVIRON. HYG., P.O. BOX 214. 2600 AE DELFT. NETH, ATMOS ENVIRON 13 (7). 1979. Language: ENGLISH 1057-1060. Coden: ATENB For the measurement of ppb concentrat1ons of vinyl chloride In ambient air. a relatively wide bore column packed with a highly selective and efficient picric acid coated Corbopack C phase was used. In the method applied, air samples were DIALOG Files: BIOSIS Previews 77-03/Jan I R&S 138448 ) (c. BIOSIS 1982) (Item 328 of 858) User 3614 25Jan83 2094 G90Stons COMPARISON OF. THE HYDROXYLATION OF BENZO A PYRENE WITH THE METABOLISM OF VINYL CHLORIDE N NITROSO MORPHOLINE AND N NITROSO-N'-METHYL PIPERAZINE TO MUTAGENS BY HUMAN AND RAT LIVER MICROSOMAL FRACTIONS SABADIE N; MALAVEILLE C; CAMUS A-M; BARTSCH II UNIT CHEM. CARCINOG.. INT. AGENCY RES. CANCER. 69372 LYON CEDEX 2, FR. CANCER RES 40 (l). 1980. 119-126, Coden: CNREA Language: ENGLISH Carcinogen metabolism In vitro was studied In 20 surgical liver specimens from adult male and female human subjects. A 60-fold 1nterIndIv1dua1 variation In aryl hydrocarbon [benzo(aJpyrene] hydroxylase activity was seen; the capacity to convert vinyl chloride. N-n1troso-N'-methy1p1perazIne and N-nltrosomorpholIne Into electrophiles mutagenic to Salmonella typhlmurlum varied 9-, 17-, and 35-fold, respectively. The mean enzymic capacity relative to liver from untreated rats was 84% for vinyl chloride, 42% for N-nItrosomorpho1 Ine and 380% for N-n1troso-N'-methy 1ptperaz1ne. When aryl hydrocarbon [benzofaJpyrene] hydroxylase activity In human liver specimens was plotted against mutagenicity In S. typhlmurlum mediated by liver mlcrosomes f rom the same spec Imens, a positive correlation was obtained In the presence of vinyl chloride (r [correlation coefficient] = 0.55: P< 0.1). N-nltrosomorphollne (r 0.86; P< 0.01), or N-n11roso-N'-me thy 1pIperazI no (r 0.94; P < 0.01). The results are discussed In relation to the possible development of methods for assessing rates of metabolism of environmental carcinogens In human subjects In vivo using nontoxlc drugs that are metabolized by the same enzymes that metabolize carcinogens. Hepatic aryl hydrocarbon [benio(a)pyrene) hydroxylase activity following treatment of rats with phenobarb1 tone, pregnono1 one - 16.a 1pha.-carbon It r11e. dIbenamI - ne, am I noaceton 11r11e or dlsulflram, but not after treatment with 3-methy1cho1 anthrene, showed a positive correlation with the mutagenicity of the respective 9000 .times. g liver supernatant fraction mediated In the presence of N-n1trosomorpho11ne, vinyl chloride or aflatoxln Bt. Cytochrome P-450-1 inked monooxygenases In rat liver apparently convert N-nItrosomorphol1ne, vinyl chloride and aflatoxln B1 Into mutagenic electrophiles. Descriptors; SALMONELLA-TYPHIMURIUM AFLA TOXIN B.-1 CARCINOGEN PHENO BARBITONE PREGNENOLONE 16-ALPHA CARBONITRILE DIBENAMINE AMINO ACETONITRILE DISULFIRAM 3 METHYL CHOLANTHRENE METABOLIC-DRUG ARYL HYDRO CARBON HYDROXYLASE CYTOCHROME P-450 Concept Codes: GENET ICS/CYTOGENET-ANIMAL(*03506); GENET ICS/- CYTOGENET-HUMAN(03508); MATHEMATIC BIOL/STATISTIC METH(04500) COMPARATIVE B10CMEM-GENL STUDIES(10010); BIOCIIFM STUD-GENERAL (10060); BIOCIIEM STUD-PROTEI NS.PEPTIUES,AM I NO ACD( 10064) BIOCIIEM STUD-PORPIIYRNS.BILE PIGM(!00G5); 0 I OPIIYS - GENE RAL BIOPHYS TECH( 10504 ); ENZYMES-GEN,COMPAR STUD,COENZYMS( 10802) ENZYMES-PHYSIOLOGICAL STUDIES! 10808) ; ANATOMY/l 11STOL-SURGERY (11105); METABOLISM-GENL STUD.MET AB PATl 1W(* 1 3002 ) METABOLISM-PROTNS,PEPTDS,AM ACDS(* 13012) ; DIGESTIVE SYST-GEN STUDS ,METITS( 14001 ) ; `DIGESTIVE SYST-PUYSIOL . B 10CI1EM( 1 4004 ) PHARMACOL-DRUG MET AB.METAB ST IMU(* 22003); TOXICOL-ENVIRONMNTL- . I NDUSTR ( *22506) ; NEQPLSMS/NEOPL AGNT S-C ARC. 1 NflGF Ns ( nwi 1 nACTCRIAL AND VIRAL GENET ICS(3 1500) ; Ml CKUU I CM 0G APPARAT.MET 1 IS.MED I A(32000): T ISS CULTURE-APPARAT.ME 1 MS.ME0 I A( - 32500); IN VITRO STUDS-CELLULR.SUBCELL(32600); MEO/CLIN MICROBIOL-MYCOLOGY(36008); PLANT PHYSIOL-CHEM CONST ITUENTS(5 I522 ) B losystemat1c Codes; ENTEROBACTERI ACEAE(04810); DEUTEROMYCE- TES( 15500): HQMINIDAE(86215); MUR I DAE(86375 ) 69051939 1 YEAR TIME SEQUENCE INHALATION TOXICITY STUDY OT VINYL CHLORIDE IN RATS 3. MORPHOLOGICAL CHANGES IN THE LIVER FERON V J; SPIT B J; IMMEL H R; KR0E5 R DEP. TOXICOL., CENT. ZEIST. NETH. INST. NUTR.. P.O. BOX 360. 3700 AJ TOXICOLOGY 13 (2). 1979. 143-154. Coden: TXCYA Language: ENGLISH Wlstar rats were exposed to atmospheres containing o (control) or 5000 ppm vinyl chloride monomer (VCM).. 7 hh//dda>a>y, 5 days/weok. for 52 wk. After 4, 13, 26 and 52 'ks each t1 me 10 rats/sex per group were killed and subject to ex tens 1ve examinations. The morphological changes found Ini t he 11ver were described. The major parenchymal changes5 compr1 sod swelling and malformation of mitochondria, an Increeansseedd amount of smooth endoplasmic reticulum, necrosis, nuc lear and cellular polymorphism of hepatocytes, foci o f cellular alteration. neoplastic nodules and hepatocellular ccaarrccin1 noommaass.. A reduced g1ucose-6-phosphatase activity In hepatoccyytes and a strong sinusoidal activity of alkaline phosphatase! wWGerre f ound within foci of cellular alteration. The i-pa renchyma1 alterations Included focal dilatation of sir i f ds , f oca 1 proliferation of atypical sinusoidal cells a mu 1 t 1 ceil t r 1 c angiosarcomas. The effects of VCM on the hepatic P arenchyma seemed to precede those on the hepatic stroma. Descriptors: GLUCOSE 6 PHOSPHATASE ALKAL PHOSPHATASE MITOCHONDRIAL SWELLING NECROSIS MULTICENTRIC ANGIO SARCOMA Concept Codes: CYTOLOGY/CYTOCHEM-AN IMAL(*02 506); BIOCHEM STUD-GENERAL( 10060); BIOCHEM STUD-PROTEI NS.PEPTIDES.AMINO ACD( 10064); ENZYMES-PHYSIOLOGICAL STUDIES( * 10008); ANATOMY/HI- STOL-MICRO.ULTRAMICRSC( 1 1 108); PATHOLOGY -INFLAMMATN.INFLAM DIS(12508); PATHOLOGY-NECROSIS(12510): METABOLISM-GENL STUD.METAB PATHWf13002); METABOLISM-PRDTNS.PEPTOS.AM ACQS(130- 12); DIGESTIVE SYST-GENL STUDS.METHS( 1 400 1 ) ; DIGESTIVE SYST-ANATOMY(* 14002): OIGESTIVE SYST-PATHOLOGY(* 14006 ) ; BLOOD/BODY FLOS-OTHER BODY FLDS(15010): RESPIRATORY SYST-GENL STUD,ME THS( 160011; BONE.JNTS,FASC,CONN/AD 1P-PA 1HOL( 10006 ) ; ROUTES Or IMMUNIZ.INFECT.THERAP(22100): TOX I COL-GENL/EXP S TUDS.METHS(2750 1 ); TOXlCOl. -ENVIRONMNTL. INDUSTR( *2 2506 ) ; NEOP- LSMS/NEOPL AGN1S-CARC I NOGENS(* 2 4 007 ); ENVIRON HE AL1II - A IR.WATR- .SL POLLNt*37015) B losystemat ic Codes: MUR I DAE(86375 ) #DI ALO e5: BIOSIS Previews 77'83/Jan BA7502;RRM2402(See FI k&S 138449 (Item 330 of 858) User 3GI4 25Jan83 205 5 6905 1930 1 YEAR TIME SEQUENCE INHALATION TOXICITY STUDY OF VINYL CHLORIDE IN RATS 2. MORPHOLOGICAL CHANGES IN THE RESPIRATORY TRACT CERUMINOUS GLANDS BRAIN KIDNEYS HEART AND SPLEEN FERON V J; KROES R DEP. TOXICOL., CENT. ZEIST, NETH. INST. NUTR., P.O. BOX 360, 3700 AJ TOXICOLOGY 13 (2). 1979, Language: ENGLISH 131-142. Coden: TXCYA Wlstar rats were exposed to atmospheres containing O (control) or 5000 ppm vinyl chloride monomer (VCM). 7 h/day, 5 days/wk, for 52 wk. After 4, 13. 26 and 52 wk each time 10 rats/sex per group were killed and subjected to extensive examinations. The morphological changes observed In the respiratory tract, ceruminous glands, brain, kidneys, heart and spleen were described. The VCM-effects Included increased degree of tubular nephrosis. mild focal degeneration of the myocard and Increased hematopoietic activity in the spleen. Primary tumors were found In the brain (ependymoma), lungs (papillary adenoma and mesenchymal type of tumor). ceruminous glands (mainly keratinized squamous cell carcinomas), and nasal cavity (carcinomas of the olfactory epithelium, care 1 no-sarcoma, es thesIoneuroep1 the 1 1oma). Descriptors: NASAL CAVITY EPENDYMOMA PAPILLARY ADENOMA MESENCHYMAL TYPE TUMOR SQUAMOUS CELL CARCINOMA OLFACTORY EPITHELIAL CARCINOMA EPITHELIOMA CARCINO SARCOMA ESTHESIO NEURO .Concept Codes: CYT0L0GY/CYT0CHEM-ANIMAL(02506); BI0C1IEM STUD-GENERAL(10060): ANATOMY/HISTOL-MICRO,ULTRAMICRSC(11108): PATHOLOGY-NECROSIS( 12510): METABOLISM-GENL STUD.METAB PATHW(1- 3002): CARDI0VA5C 5YST-HEART PATHOLOGY(*1450G); BLOOD/BODY FLDS-BLD.LYM.RES P ATH( * 15006 ) ; BLOOD/BODY r I.OS - L YMPI1A T TISS.RES( 15008) ; IJRIN SYST/EXT SECR - PAT! 10L0GY ( 15506 ) ; RESPIRATORY 5YST-GENL STUD.METHS( 16001); RESPIRATORY SYST-PATHOLOGY(* 16006); BONE.JNTS.FASC,CONN/AO IP-PATHOL(* 18006); SENSE ORGANS - ANATOMY- (20002): SENSE ORGANS - PA11IOLOGY(*20006); NERVOUS SYST'PA 11IOLO- GY ( * 20506 ) : R0UTE5 OF IMMIJNI Z. INFECT , T11T R A P ( 22 100) : 10XIC0L-GENL/EXP STUDS,METHS(22501); TOXI COL-ENVIRONMNTL. INDU- STR(*22506); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(24007); ENVIRON HEALTH-AIR,WATR,SL POLLN(37015) Blosystemat1c Codes: MURIDAE(8G375) exposed to" high PVC dust Icvols. The chest X-ray changes were observed after a minimum oxposuro of 5 yr and. In a small percentage of cases. were associated with slight restrictive respiratory function impairments. In the whole group of workers 380 cases (31.9%) were found with non-specific X-ray abnormalities mainly related to age and smoking. Descriptors: HUMAN RESPIRATORY IMPAIRMENTS AGE SMOKING Concept Codes: MATHEMATIC BIOL/STATISTIC METH(04500) ; SOCIAL BIOL/HUMAN ECOLOGY(05500); RADIATION BIOL-RAOTN,I SOTpP TECH(06504); BEHAVIOR BIOL-HUMAN BEHAVIOR(07004); ECOLOGY-BIO- CL IMATOL.BIOMETEOROL(07504 ); BIOCHEM STUD-GENERAL( 10060); ANATOMY/HISTOL-RAD IOLOGIC( 1 I 106): CHORDATE BODY RGNS-THORAX(- 11312); METAB0L1SM-GENL STUD,METAB PATHW( 13002): RESPIRATORY SYST-GENL STUD.METHS(16001); RESPIRATORY SYST-PHYSIOL,BIOCHEM(16004): RESPIRATORY- SYST-PATHOLOGY(* 16006); PSYCHIATRY-AOOIC- T1 ON(INC SMOKNG)(21004); TOXI COL-GENL/EXP STUOS.METHS(2250 1 ) : TOXICOL-ENVIRONMNT L,INDUST R(* 22506); PUB HEALTH-ADM 1NISTR.STA- TIST ICS(*370 10); ENVIRON HEALTH-OCCUPATNL HEALTH( 370 13 ) : ENVIRON HEALTH-AIR.WATR.SL P0LLN(37015); EPI DEM IOL-ORGAN IC DIS,NEOPLASMS!*37054 ); PLANT PHYSIOL-CHEM CONSTITUENTS(5 1 522 ) ; AGRONOMY-TOBACCO CROPS(52512) Blosystomat(c Codes: SOLANACEAE(26775): MOMINI0AE(86215 ) 69047209 POLY VINYL CHLORIDE PNEUMOCONIOSIS EPIDEMIOLOGICAL STUDY OF EXPOSED WORKERS MASTRANGELO G; MANNOR M; MARCE R G: BARTOLUCCI G B: GEMIGNANI C; SAl.ADINO G; SIMONATO L; SAIA B INST. INQ. MED.. UNIV. PADOVA, PADOVA. ITALY. J OCCUP MED 21 (8). 1979. 540-542. Coden: JOCMA Language: ENGLISH Among 1216 workers who wore employed In a polyvinyl chloride [PVC] production factory and who had had no previous dust exposure elsewhere, 20 cases of pneumoconiosis were found. Chest X-ray abnormalities were characterized by limited profusion, Irregular type and low gravity. All 20 workers were DIALOG FUe5: BIOSIS Previews 77-83/Jan 8A7502;RRM2402(See file 690-10820 ACUTE HEPATO TOXICITY OF VINYL CHLORIDE AND ETHYLENE MODIFICATION BY TRI CHLORO PROPENE OXIDE DI ETHYL MALEATE AND CYSTEINE CONOLLY R 8; JAEGER R J IMP. CHEM. IND. LTD., CENT. TOXICOL. LAB.. ALDERLEY PARK. CHESHIRE SK10 4TJ, ENGL.. UK. TOXICOL APPL PHARMACOL 50 (3). 1979. 523-532. Coden: TXAPA Language: ENGLISH Vinyl chloride (VC) and ethylene are acutely hepatotoxlc In rats pretreated with po1ychlor Inated blophenyl {PC8 ). Several chemical treatments were used to Investigate the mechanisms of acute VC and ethylene toxicity In PCB-pretreated rats. TrIchloropropene oxide (TCPO) depletes hepatic glutathione (GSH) and Inhibits hepatic epoxide hydrase (EH). 01othy1ma1eate (OEM) also depletes hepatic GSH. Cysteine Is a rate-1ImltIng precursor In hepatic GSH synthesis. Effects of these various treatments on VC and ethylene toxicity were compared with their Influence on hepatic GSH concentrations. Exposures to vc and ethylene were by Inhalation at 1000-50.000 ppm. TCPO significantly Increased VC toxicity in fasted but not in fed rats. Ethylene toxicity was not affected by TCPO. These actions of TCPO were not attributable to changes In hepatic GSH. DEM significantly lowered GSH during exposure, but did not Increase the hepatotoxIcIty of either VC or ethylene, suggesting either that hepatic GSH concentrations are not an Important determinant of the acute response to vc and ethylene or that DEM has Important effects In addition to hepatic GSH depletion. Cysteine protected significantly, though Incompletely, against acute VC hepatotox 1cIty, There was no effect of cysteine on the toxicity of ethylene. In PCB-treated rats. hepatic GSH and EH Influence the acute hepatotoxlclty of VC, but not that of ethylene. Descriptors: RAT ANTIDOTE POLY CHLORINATED 81 PHENYL EPOXIDE HYDRASE GLUTATHIONE DEPLETION PROTECTION EASTING Concept Codes: BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-PROTEINS.PEPTrOES.AMINO ACD(10064): BIOCHEM STUD-CAR80HY- DR.(10068): ENZYMES-CHEM,PHYSICAL STUD IES( 10806); ENZYMES-PHY- SIOLOGICAL STUDIES(* 10808); METABOLISM-GENL STUD,METAB PATHW( * 13002) ; MET ABOLI SM-C ARBOHYDR AT E S ( * 13004 ) ; METABOLISM-P- ROTNS.PEPTDS.AM ACDS(13012): NUTRITI ON-MALNIJ TRITI ON.OBESITY(- 13203); RESPIRATORY SYST-GENL STUD,METHS(16001); RESPIRATORY SYST-PATHQLOGY( 1G006); PHARMACOL-DRUG METAB.METAB $TIMU(*220- 03); ROUTE5 OF IMMUNIZ.INFECT,THERAP(22100); TOXICOL-GENL/EXP STUDS.METHS(*22501 ); TOXI COL-ANT I DOTES.PREVENT IVE(*22 505); TOXICOL -ENVIRONMNTL,INDUSTR(22506); ENVIRON HEALTH-A IR.WATR.SL POLLN(37015) B losysteinat Ic Codes; MURIDAE ( 86375 ) DIALCK^^Pe5: BIOSIS Previews 77-03/Jan BA7502;RRM2402(Se< R 6903B469 ACTIVATION OF VINYL CHLORIDE TO COVALENTLY BOUND METABOLITES ROLES OF 2 CHLORO ETHYLENE OXIDE ANO 2 CHLORO ACETALDEHYDE GUENGERICH F P; CRAWFORD W M OR; WATANABE P G DEP. BIOCHEM., VANDERBILT UNIV. SCH. MED., NASHVILLE, TENN. 37232, USA. BIOCHEMISTRY 18 (23). 1979. 5177-5182. Language: ENGLISH Coden: BICHA 2-Ch1oroethy1ene oxide, a postulated metabol Ite of vinyl chloride [a potential carcinogen], rearranged' to 2-chloroacetaldehyde and hydrolyzed (and dehydrochlormated) to glycola 1dehyde In aqueous buffer. The hydrolysis was catalyzed by apparently homogeneous preparations of rat liver microsomal epoxide hydratase; purified hydratase also lowered the tl/2 (half time] of the epoxide in aqueous buffer. 2-Chloroacetaldehyde was reduced by horse liver alcohol dehydrogenase In the presence of NADU and oxidized by yeast aldehyde dehydrogenase In the presence of NAD +. The NADPW-dependont covalent binding of [14C]vtny1 chloride to protein was examined In systems containing rat liver mlcrosomes or highly purified rat liver cytochrome P-450 and NADPH-cytochrome P-450 reductase. Since g1yco1 a 1dhyde. 2-chloroethanol and 2-chloroacet1c acid are relatively weak alkylating agents, the effects of epoxide hydratase and alcohol and aldehyde dehydrogenases on covalent binding were examined. In a reconstituted system containing cytochrome P-450 and Its reductase, > 90*/, of the covalent binding of 14C label from vinyl chloride was blocked by the addition of epoxide hydratase. In the microsomal system only 507. of the covalent binding could be blocked by epoxide hydratase but > 907. of binding was blocked with alcohol or aldehyde dehydrogenase. In the microsomal system, neither Inhibition of endogenous' hydratase with 3,3,3-trlehloropropy1ene oxide nor enhancement,of hydratase activity by pretreatment of rats with trans-stIIbene oxide affected the level of covalent binding of label from (14C]v1nyl chloride. The use of highly purified enzymes In elucidating the chemistry of activation of compounds to reactive metabolites was demonstrated and the following statements were Indicated: cytochrome P-450 activates vinyl chloride; 2-chloroethylene oxide Is formed from vinyl chloride; 2-ch1oroethy1ene oxide Is a substrate for epoxide hydratase; the rearrangement product 2-ch1oroaceta1de hyde Is an Important alkylating agent derived from vinyl chloride: and cytochrome P-450 Is effectively segregated from epoxide hydratase and highly nucleophilic groups In microsoma I membranes In this process. A highly electrophilic metabolite apparently can form a less reactive compound which may be more effective In biological alkylations. Descriptors: RAT HORSE YEAST 333 TRI CHLORO PROPYLENE OXIDE ENZYME INHIBITOR-DRUG TRANS S1ILBENE OXIDE METABOLIC-DRUG ALDEHYDE ALCOHOL DEHYDROGENASE MEMBRANE DEHYDROGENASE EPOXIDE HYDRATASE NAOH CYTOCHROME P-450 MICROSOMAL Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506); RADIATION BIOL-RADTN.ISOTOP TECH(06504); COMPARATIVE BIOCMEM-GENL STUDIES( 1001O); BIOCHEM STUD-GENERAL( 10060): BIOCHEM STUD-NUCL ACD,PURNS,PYRM( 10062); BIOCHEM ST IID-PROTEI NS.PEPTIDES.AMI NO AC0(10064);' BIOCHEM STUD-PORPHYRNS,BILE PIGM(10065); 138451 82) (Item 333 of 858) User 3614 25jan83 2097 BIQPMY S-MOLE CUL PROP.MACROMOLEC( 10506); BIOPIIYS-MCMBRANE PHENOMENA! 10508); ENZYMES-GEN.COMPAR STUO,COENZYMS( 10002); ENZYMES-METHODS! * 10804): ENZYMES-CHEM,PHYSICAL STUD IES( 10806); ENZYMES-PMYSIOLOGI CAL STUD IE5(* 10808): METABOLISM-GENL STUD,ME TAB PATHW(13002); METABOLISM-PROTNS,PEPTDS.AM ACDS(*1- 3012); DIGESTIVE SYST-PHYSIOL.BIOCHEM(14004); PHARMACOL-DRUG ME TAB.METAB ST 1 MU(22003); TOXI COL-GENL/EXP STUDS.METHS( 2250 1 ) ; NEOPLSMS/NEOPL AGNT5-CARC INOGENS(* 24007) B losystemat Ic Codes: FUNGl-UNSPECIFI ED( 15000 ) : EOUIDAE(86 1 4- 5); MURIDAE(B6375) (iDIALOG me6: BIOSIS Previews 77-83/Jan BA7502;RRM2402(See FUe55) R&S 138452 34 of 858) User 3614 25Jan83 2098 69034047 1 YEAR TIME SEQUENCE INHALATION TOXICITY STUDY OF VINYL CHLORIDE IN RATS 1. GROWTH MORTALITY HEMATOLOGY CLINICAL CHEMISTRY AND ORGAN WEIGHTS FERON V J; KRUYSSE A; TIL H P DEP. TOXICOL., CENT. INST, NUTR. FOOD RES, TNO, P.O. BOX 360, 3700 A ZEIST. NETH. TOXICOLOGY 13 (1). 1979. 25-28. Coden: TXCYA Language: ENGLISH Wlstar rats were exposed to atmospheres containing O (control) or 5000 ppm vinyl chloride monomer (VCM) [a potential carcinogen). 7 h/day, 5 days/wk, for 52 wk. After 4. 13, 26 and 52 wk 10 rats/sex per group were killed and subjected to extensive examinations. Growth. mortality, hematology, clinical chemistry and organ weights were studied. Slight growth retardation throughout the experimental pehlod and high mortality In the 2nd half of the study were observed In VCM-exposed animals. Some of the hematological parameters and biochemical blood parameters were slightly Influenced by VCM after an experimental period of 52 wk. Blood clotting time was generally slightly shorter In VCM-exposed rats than In controls. There were minor Indications of Increased K contents In the blood serum In VCM-exposed animals during the 1st half of the test period. That the kidneys were adversely affected by VCM was evidence by Increased blood urea N levels and relative kidney weights. After 52 wk Increased weights of heart and spleen, and slight signs of anemia were noticed In VCM-exposed rats. The present study did not produce obviously suitable parameters for early diagnosing VCM-dlsease In man. [The effect of VCM exposure on Industrial dIscussed). safety was Descriptors: HUMAN KIDNEY PATHOLOGY HEART SPLEEN GROWTH RETARDATION ANEMIA BLOOD CLOTTING POTASSIUM CONTENTS NITROGEN LEVELS Concept Codes: BIOCHEM-GASES( 100 I 2); BIOCHEM STUD-GENERAL(t- 0060): BIOCHEM STUD-PROTEINS,PEPTIOES,AM I NO ACD( 10064): MINERALS( 10069); PHYSIOLOGY-GENERAL STUDIES( 12002); PHYSIOLOG- Y-COMPARATIVE( 12003); PATHOLOGY-DIAGNOSTIC( 12504); PATHOLOGY -- NECROSIS(12510); MINERALS(*13010); METABOLISM-PROTNS,PEPTDS.AM ACDS(* 13012); CARD IOVASC SYST-PHYSIOL.81OCHEM( 14504 ); BLOOD/B ODY ELDS-BLOOD,LYMPH STUD(t5002): BLOOD/BODY ELDS-BLD,LYM,RES PATH(*15006); BLOOD/BODY ELDS -LYMPHAT TISS.RES( 15008); URIN SYST/EXT SECR-PATHOLOGY(* 15506); RESPIRATORY SYST-PHYS1OL,B10 - CHEM( 16004); TOXI COL -ENVIRONMNTL.INDUSTR(*22506); NEOPL SMS/NE- OPL AGMT S-CARC INOGENS(24007); DEVELOPMNTL BIOL-GEN MORPIIC,ENSIS( *25508) : ENVIRON HEALTH-OCCUPATNL HEALTH( *370 13 ) Blosystemat1c Codes: HOMINIDAE(86215); MUR I DAE(86375) 69031414 FORMATION ' AND INACTIVATION OF A CHEMICALLY REACTIVE METABOLITE OF VINYL CHLORIDE IN RATS PESSAYRE D; WANDSCHEER J C: DESCATOIRE V; ARTIGOU J Y; BENI IAMOU J P UNITE RECH, PHYSI OPATHOL. HEPATIQUE. INST. NATL. SANTE RECII. MEO.. HOP. BEAUJON. 92118 CLICHY, FR. TOXICOL APPL PHARMACOL 49 (3). 1979. 505-51G. Codon: TXAPA Language: ENGLISH The mechanisms responsible for, and protecting against, metabolic activation of vinyl chloride [a potential carcinogen) were Investigated In the rat. When [14C)v1nyl chloride was Incubated with hepatic mlcrosomes, a 14C-laboled material became Irreversibly bound to microsomal proteins; binding required NAdph. was decreased by CO. SKE 525-A or glutathione, and was Increased by 1, 1. 1 -1rIch1oropropeno-2.3 - - oxide (TCPO). Inhalation of a 5% vinyl chloride atmosphere decreased hepatic cytochrome P-450 and gluthathionc. Pretreatment of the animals with DDT or phenobarb 1 ta1 Increased in vitro Irreversible binding to microsomal proteins measured In the presence, but not In the absence. of TCPO and Increased the in vivo loss of cytochrome P-450 during Inhalation of vinyl chloride but decreased the In vitro Irreversible binding to 10,000 g supernatant proteins and the In vivo loss of glutathione during Inhalation of vinyl chloride. These results are consistent with the following views: vinyl chloride Is activated by cytochrome P-450 Into Its chemically reactive epoxide; the epoxide may be Inactivated by epoxide hydrase or by binding to glutathione: pretreatment with DDT or phenobarbIta I Increases the formation rate of the epoxide and Its Inactivation rate by epoxide hydrase and cytochrome P-450 destruction Is related to the formation rate of the epoxide. whereas glutathione depletion seems related to only that fraction of the formed epoxide which has escaped Inactivation by microsomal epoxide hydrase and has diffused In the cytosol. [The effect of vinyl chloride on Industrial workers was discussed.) Descriptors: HUMAN CARCINOGEN HEPATIC MICROSOME CARBON MON OXIDE SKF-525-A GLUTATHIONE 1 I 1 TRI CHLORO PROPENE 2 3 OXIDE PHENO BARBITAL METABOLIC-ORUG DDT INSECTICIDE EPOXIDE HYDRASE CYTOCHROME P-450 NADPH Concept Codes: CYT0L0GY/CYT0CMEM-ANIMAL(O25O6); RAO I A TI ON BIOL-RADTN,ISOTOP TECH(06504); COMPARATIVE BIOCHEM-GENL STUDIESt 10010); BIOCHEM-GASES( 10O12); BIOCHEM STUD-GENERAL( 10- 060): BIOCHEM STUD-NUCL ACO.PURNS.PYRM( 10062 ) : BIOCHEM STUD-PROTEINS,PEPTIDES,AMINO ACO( 10064): BIOCHEM STUD-PORPHYR- NS,BILE PIGM(IOOGS): BIOPHYS-GENERAL BIOPHYS TECH(10504): ENZYME5-GEN,COMPAR STUD.COENZYMS( 10802): MOVEMENT( 1 2 100 ) : METABOLISM-GENL STUD,METAB PATHWf* 13002); METABOLISM-PROTNS.P- EPTOS.AM ACOS(* 13012): METABOLISM-PORPHYRI NS.BILE PIGMN( 13013) ; DIGESTIVE SYST-PHYSIOL.BIOCMEM(* 14004); RESPIRATORY SYST-PHYSIOL.BIOCHEM( 16004); PHARMACOL-DRUG MET AB.MET AB STIMU(22003); TOXICOL-GENL/EXP STUDS.METHS(22501): TOXICOL-E- NVI RONMNTL , INDUSTR( *22506 ) : NEOPLSMS/NEOPL AC.NT S -CARC INOGE NS ( - *24007); IN VITRO STUDS-CELLULR.SUBCELL(32600): PEST CONrRI. GENL/PEST ICS/HERBICS(54GOO); ECONOM ENTOMOL-CHEM PHYS CONI Rl. ( GOO 16 ) B losys1omat lc Codes: HOMIN1DAE(862 15 ) ; MUR I 0AC( 86375 ) : ABSTRACTS Of T. NTOMOLOGY ( 96000 ) DIALOG FlleS: BIOSIS Previews 77-83/Uan 0A7502;RRM2402(See FtleSS) (c. biosi; R&S 138453 58) User 3614 25Jan83 2099 69026559 THE OCCURRENCE OF ALIPHATIC CHLORINE AND BROMINE COMPOUNDS IN AUTOMOBILE EXHAUST HASANEN E; S01NINEN V; PYYSALO H: LEPPAMAK1 E CHEM. LAB., TECH. RES. CENT. FINL., 02150 ESPOO 15. FINE. ATMOS ENVIRON 13 (8). 1979. Language; ENGLISH 1217-1220. Coden: ATENB A glass capillary gas chromatographic method was used to Investigate whether automobile exhaust contains the scavenging substances of Pb added to gasoline, l.e., 1,2-dIbromoethane and 1.2~dIch1oroethane. and their degradation products vinyl bromide and vinyl chloride. Exhaust gases were also examined for the presence of methyl chloride, dIch1oromethane, chloroform. carbon tetrachlor 1 do, 1, 1,1 - trI chioroethane, trIchloroethy1ene and tetrachloroethylene, which were Identified In urban air. None of these compounds could be detected In the exhaust gases. The detection limits were 2 mg/m3 for methyl chloride. 0.5 mg/m3 for dIch1oromethane and for the other compounds Investigated, 0.05 mg/m3. Based on the neutron activation analytical method, automobile exhaust contained 1.0 .+-. 0.3 mg/m3 gaseous Cl compounds. so far unidentified. and corresponding Br compounds about 0.7 0.3 mg/m3, when Finnish 99-octano gasoline (Pb contont 0.59 g/1) was used. Descriptors: TETRA CHLORO ETHYLENE TRI CHLORO ETHYLENE 1 1 1 TRI CHLORO ETHANE I 2 DI BROMO ETHANE 1 2 DI CHLORO ETHANE VINYL BROMIDE VINYL CHLORIDE METHYL CHLORIDE 1)1 CHLORO METHANE CHLOROFORM CARBON TETRA CHLORIDE LEAD Concept Codes: ECOLOGY-BIOCLIMATOL.BIOMETEOROL(*07504): BIOCHEM METH-GENERAL(* 10050): BIOCHEM STUD-GENERAL(* 10060): BI0PHY5-GENERAL BIOPHYS TECH(10504); MOVEMENT(12100); TOXICOL-ENVIRONMNTL,INDUSTR(* 22506); ENVIRON HEALTH-A1R.WATR.SL POLLN(*37015) 69017757 METABOLIC AND MUTAGENICITY STUDIES ON DOT AND 15 DERIVATIVES DETECTION OF 1 1 BIS- P CHLOROPHENYL-2 2-DICHLQRO ETHANE AND 1 1 BIS- P CHLOROPHENYL-2 2 2-TRICHLOROETHYL ACETATE KELTHANE ACETATE AS MUTAGENS IN SALMONELLA-TYPHIMURIUM AND OF 1 1 BIS- P CHLOROPHENYL ETHYLENE OXIDE A LIKELY METABOLITE AS AN ALKYLATING AGENT PI.ANCIIF. G; CROISY A; MALAVEILLE C; TOMATIS L; BARTSCH H UNIT CHEM. CARCINOG., INT. AGENCY RES, CANCER. 150 COURS ALBERT-THOMAS. 69372 LYON, FR. CHEM-BIOL INTERACT 25 (2-3). 1979. 157-176. Coden: CBINA Language: ENGLISH Using a novel In vitro technique whereby microsomal enzymes were embedded In an agar layer to prolong their viability. 1.1-b1s(p-chloropheny1) ethylene (DDNU), a mammalian metabolite of 1 , 1-bIs(p-ch1oropheny1)-2,2,2-1rI chioroethane (ODT), was converted by microsomal monooxygenases of mouse liver .Into 1,1-bIs(p-chloropheny1)-1,2-ethanedIo1 (DDNU-dlol). The putative epoxide Intermediate, 1,1-b1s(p-chloropheny1)eth- ylene oxide (DDNU-ox 1de), a new compound, was synthesized and f + ..t,*,! *r. I, 1 'I ............ - ..............I dine but was not mutagenic In S. typhlmurlum strains TAiOO and TA90, ODT and 13 of Its metabolites or putative synthetic derivatives. Including 1. 1-bIs(p-chloropheny1)-2.2~dIch1oroet - hylene (DDE), 1. 1-bIs(p-ch1oropheny1)-2-ch1oroethy 1ene (OOMU). 1 . 1 - bIs(p-chloropheny1)-2-ch1oroethane (DDMS)-DDNU. 2.2 -b I s(p- -ch1oropheny1)ethano1 (DDOFI), bIs(p-ch1oropheny1)acet Ic acid (DDA) and 1, 1-bIs{p-chloropheny1)-2,2,2-tr1ch1oroethano1 (Kolthane), caused no mutagenic effects In S. typhlmurlum TAIOO or TA98, either In the presence or absence of a mouse liver microsomal fraction. Kelthane acetate [ 1 . 1 -bIs(p-ch1oro pheny 1 ) - 2,2.2 - t r I c.h 1 oroe t hy 1 acetate) was a direct-act lag mutagen In strain TA 100. whereas 1. |-bls(p-chloropheny1 ) - 2.2 - - dIch1oroethane (DDD) was mutagenic In TA98 only In the presence of mouse liver mlcrosomos. Possible pathways whereby DDT Is activated to mutagenic and/or carcinogenic metabolites are discussed. Descriptors: TA-98 TA-100 STRAINS MOUSE LIVER MICROSOME MONO OXYGENASE 1 I BI5-P CHLOROPHENYL ETHYLENE I t BIS-P CHLOROPHENYL-1 2 ETIIANEDIOL 4-4 NITROBENZYL PYRIDINE I 1 OIS-P CHLOROPHENYL-2 2-DICHLORO ETHYLENE 1 1 BIS-P CHL0R0PHENYL-2-CHL0R0 ETHYLENE 1 I BIS-P CHLOROPHENYL-2-CHLORO ETHANE 2 2 BIS-P CHLOROPHENYL ETHANOL BIS-P CHLOROPHENYL ACETIC-ACID 1 1 BIS-P CHLOROPHENYL-2 2 2-TRICIILORO ETHANOL MUTAGEN CARCINOGEN INSECTICIDE AGAR Concept codes: CYTOLOGY/CYTOCHEM-ANIMAL(*02506); GENETICS/C- YTOGENET-ANIMAL(*03506); BIOCHEM STUD-GENERAL(10060): BIOCHEM SUJD-NUCL ACD.PURNS,PYRM( 10062): BIOCHEM STUO-PROTEI NS.PEPTID- ES.AMINO ACD( 10064 ); BIOCHEM STUD-CARBOHYDR.( 10068 ) ; ENZYME 5-METHODS!* 10004); ENZYMES-PHYSIOLOGICAL STUD I ES( 10808 ) ; METABOLISM-GENL STUD.METAB PATHW(* 13002); METABOLISM-PROTNS - ,PEPTDS.AM ACDS( 13012): METABOLISM-NUCL ACD.PUR I NS.PYRIM( 1 30 - 14); DIGESTIVE S Y ST - PHY S I OL , B IOCHEM ( 1 4004 ) ; T OX I COL - C.E NL/E XP STUDS,METIIS(22501); TOXI COL-ENVIRONMNTL. INDUSTR(* 22506); NEOP- L SMS/NEOPL AGNTS-CARCINOGENS(*24007); BACTERIAL AND VIRAL GENETICS(31500): MICROBIOLOG APPARAT,METHS.ME0 I A(32000): IN VITRO STUDS-CELLULR.SUBCELL(32600): PEST CONTRL GENI./PESTICS/- HERBICS(54600): ECONOM ENTOMOL-CHEM PHYS CONTRL(60016) Blosystemat1c Codes: ENTEROBACTERI ACEAE(04810): MURIDAE(863- 75); ABSTRACTS OF ENTOMOLOGY(96000) DIALOG F l 1 e 5 ; BIOSIS Previews 77-83/Jon BA7502;RRM2402(See F11o55) (c. BI R&S 138454 f 858) User 3614 25Jan83 2 lOO 69015057 RISKS TO THE OFFSPRING FROM PARENTAL OCCUPATIONAL EXPOSURES HAAS 0 F: SCHOTTENFELD D CORNELL UNI V. MED. COLL., 10021, U5A, 1300 YORK AVE. , NEW' YORK, N.Y. J OCCUR MED 21 (9). 1979. 607-613. Coden: JOCMA Language: ENGLISH Risks to the offspring of workers with occupational chemical exposures may derive from mutagenic, teratogenic or carcinogenic effects of Industrial agents to which the parents are exposed. Evidence for Impaired pregnancies and hazards to the offspring of working populations with chemical exposures Is very limited. Perhaps the best documented example Is Increased spontaneous abortion rates In female operating room personnel who have 1st trimester exposure to waste anesthetic gases. Evidence is reviewed for hazards to the offspring resulting from parental occupational exposure to vinyl chloride. benzene, chloroprene, radiation and petroleum-derived hydrocarbons. It Is essential In Investigating the role of 'occupational factors that other environmental and behavioral factors with major effects on pregnancy outcome be accounted for. These Include smoking, alcohol and drug exposures. An approach to surveillance for chromosomal abnormalities in offspring of occupationally exposed parents Is outlined. Descriptors: HUMAN CHROMOSOMAL ABNORMALITIES MUTAGEN TERATOGEN CARCINOGEN INDUSTRIAL AGENTS SPONTANEOUS ABORTION ANESTHETIC GASES VINYL CHLORIDE BENZENE CHLOROPRENE RADIATION PETROLEUM DERIVED HYDRO CARBONS SMOKING ALCOHOL Concept Codes: CYTOLOGY/CYTOCHEM-HUMAN(O25O0); GENETICS/CYT- OGENET-HUMAN(*03508); RADIATION BIOL-RAOTN EFF.PROTECT(*06506) ; BEHAVIOR BIOL-HUMAN BEHAVIOR(*07004); BIOCHEM STUD-GENERAL(10060); METABOLISM-GENL STUD.METAB PATHW( 13002): REPRODUCT SYST-PATHOLOGY( 16506); NERVOUS SYST-GENL STUDS.METHS(20501); PSYCH!ATRY-ADDICTION(INC SMOKNG)(21004); PHARMACOL-NEUROPHARMACOLOGY(22024); TOXICOL-GENL/EXP STUDS.ME - THS(*22501 ); TOXICOL-PHARMACOLOGICAL!*22504); TOXI COL-ENVIRON- MNTL,INDUSTR(*22506): NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(*24007) ; DEVELOPMNTL 81DL-PATH0LDG1CAL(*25503); DEVE LOPMNTL BIOL-DESCRIP TERATOL(*25552); ENVIRON HEALTH-OCCUPATNL HEALTH(*37013): ENVIRON HEALTH-A IR.WATR.SL POLLN(37015); ENVIRON HEALTH-RADIATION HEALTH(*37017); PLANT PHYSIOL-CHEM CONSTITUENT5(51522); AGRONOMY-TOBACCO CR0PS(525I2) BlosystematIc Codes: PLANTAE-UNSPECIFI ED( 1 1000); HOMJNIDAE(- 86215); BIOSIS INTERNAL USE(97000) 69014195 POLY VINYL CHLORIDE MEMBRANE FOR A GLUCOSE SENSOR HIROSE S; HAYASHI M; TAMURA N; SUZUKI S: KARUOE I CENT. RES. LAB. , MITSUBISHI PF.TROCMEM. CO. LTD.. INASI IIKI, IBARAGI 300-03, JPN. J MOL CATAL 6 (4). 1979. 251-260. Coden; JMCAD Language: ENGLISH Glucose oxidase (EC 1. 1.3.4) (20 mg/g of carrier) Immobilized on a porous polyvinylchloride membrane (PVC). pt^hl 1 i h/ Of rilurnra. i^ .. AMI. was The ' `' Immobilization. The glucose oxIdase-PVC membrane was applied as a glucose sensor. as assay, reproducible within 7'/. relative error, was completed within 1 min by the steady state method and within 15 s by the kinetic method. Glucosel concentrations of fresh (human) sera were determined by the sensor which remained viable for more than 2 mo. Descriptors: HUMAN GLUCOSE OXIDASE EC-1.1.3.4 ENZYME IMMOBILIZATION Concept Codes: CLIN BIOCHEM-GENL STUD IES(*10006): BIOCHEM METH-CARBOHYDRATES(* 10058); BIOCHEM STUD - PROTEI NS.PEPTIDES.AM INO ACD( 10064); BIOCHEM STUD-CARBOHYDR.( 10068): BIOPHYS-GENER- AL BIOPHYS TECH(10504); 0 IOPHYS-MEMBRANE PHENOMENA( 1050B ) ; BIOPHYS-BIOENGINEERING!* 10511); ENZYMES-METHODS( 10804); METAB OLISM- CARBOHYDRATES(13004); BLOOD/B00Y FLDS-BLOOQ,LYMPH STUD(* 15002) BtosystemntIc Codes: HOMINI DAE(862 1 5) 69013353 SCLERODERMA SIMULATING VINYL CHLORIDE DISEASE BRETZA J; GOLDMAN J A EMORY UNI V. SCH. MED. , USA . 69 BUTLER ST. S.E., ATLANTA. GA. J OCCUP MED 21 (6). 1979. 436-438. Coden: JOCMA Language: ENGLISH Progressive systemic sclerosis. especially prior to distinctive internal organ involvement. can be difficult to distinguish from vinyl chloride disease. A 50 yr old male developed classic scleroderma while working with polyvinyl chloride. Early In his disease he displayed a number of features common to both disorders. Including ncroosteolysIs, sc 1erodacty1y, po1ygammopathy and circulating Immune complexes. Characteristic visceral Involvement was the cardinal feature which distinguished his disease from the pseudoscIerodcrma of vinyl chloride disease. Descriptors: HUMAN WORKER PROGRESSIVE SYSTEMIC SCLEROSIS ACRO OSTEOLYSIS SCLERO DACTYLY POLY GAMMOPATHY CIRCULATING IMMUNE COMPLEXES Concept Codes: SOCIAL BIDL/HUMAN EC0L0GY(O55O0); BIOCHEM STUO-GENERAL( 10060): BIOCHEM STUD-PROTEI NS.PEPTIDES.AMI NO ACD(10064); BIOCHEM STUD-CARBOHYDR.( 10068): CHORDATE BODY REGNS-EXTREMITIES( 1 1318); PATHOLOGY - GENERAL STUD IES( 12502 ) : PATHOLOGY-COMPARATIVE(12503); METABOLISM-CARBOHYDRATES(13004): METABOLISM-PROTNS.PEPTDS.AM ACDS(13012); BONE.JNTS.FASC.CONN/- ADIP-PATHOL(* 18006); INTEGUMENT SYST-PATHOLOGY(* 18506); TOXI COL -ENVIRONMNTL,INDUSTR(*22506): IMMUNOL/IMMUNOCHEM-IMMUNOPATHOL(*34 508); ENVIRON HEALTH-OCCUP - ATNL HEALTH!*37013); ENVIRON HEALTH-AIR.WATR.SL POLLN( * 370 1 5 ) B losystomatIc Codes: HOMINIDAE(06215) DIALOG gS: BIOSIS Previews 77-83/Uan BA7502 ; RRM2402 ( See F I I e55) (c. BIOSIS 1982) R&S 138455 tr 36 1 A 25 J an03 2 10 1 690133-15 OCCUPATIONAL ACRO OSTEOLYSIS IN VINYL CHLORIDE WORKERS IN ISRAEL HAHN E: ADERKA D; SUPRUN H; SHTAMLER B DEP. RADIOL., NAHARIYA GOVT. HOSP., NAHARIYA, ISR. ISR d MED SCI 15 (3). 1979. 218-222. Coden: IJMDA Language: ENGLISH Exposure to vinyl chloride monomer (VCM) may result In a bizarre syndrome, which Is character 1 zed by lytic changes In the distal phalanges, cutaneous stigmata of scleroderma' and Raynaud's phenomenon. Detailed case histories of 2 such patients are presented. Epidemiologic. pathogenetic and radiological aspects of occupa11ona1 acroosteo1ys I s are briefly reviewed. The possibility Is emphasized that the condition may result not only from Industrial (l.e.. occupational) exposure to VCM but also from exposure In. the home or neighborhood (l.e., nonoccupatIona1). DoscrIptors: HUMAN SKIN FINGERS SWELLING DISTAL PHALANGE LYTIC CHANGES SCLERODERMA CUTANEOUS STIGMATA RAYNAUDS PHENOMENON EPIDEMIOLOGY PATHOGENICITY RADIOLOGY X-RAY HOME EXPOSURE Concept Codes: PHOTOGRAPHY-METHS,MATLS,APPARAT(01012); SOCIAL BIOL/HUMAN ECOLOGY(0G500): RADIATION BIOL-RADTN.ISOTOP TECH(0G504); BIOCHEM STUD-GENERAL { 10060 ) ; ANATOMY/HI STOL - RADI OLOGIC ( 1 1 106 ) ; CHORDATE BODY REGNS-EXTREMITIES( 1 1 3 1 8 ) ; PHYSIOLOGY-INSTRUMENIATI0N( 12004): PATHOLOGY-0 IAGNOSTIC( 1250-1) ; PATHOLOGY-INFLAMMATN,INrLAM 015(12500); BLOOD/BODY FLDS-OTHER BODY FLDS(15010); BONE,JNTS,FASC.CONN/AD IP-PATHOL(- *18006): INTEGUMENT SYST-PATHOLOGY(*1B50G); TOXI COL-ENVIRONMN- TL.INDUSTR(*22506); ENVIRON HEALTH-OCCUPATNL HEALTH(*37013): ENVIRON HEALTH-AIR.WATR,SL POLLN(*37015); EPI DEM IOL-MISCELL STUDlES(37056) Blosystemat1c Codes: HOMINIDAE(06215) Increase ovor the time cours a of DOMIJ adm I n I stral I on. 7 ho plasma itpld level was reduced after -l days whereas t ho hepatic lipid content was subs tantially Increa sed sugge sting that the fatty liver condition may be caused by deer eased liver triglyceride release. P lasma glucose wa s reduced at 8 days but there was no evidence o f a hyperglyceml c state, T ho changes noted after 2 days of DDMU diet wer e conf1rm ed by measurements on birds 18 h after ora 1 dosIng wit h DDMU. The study demonstrates the appar ent value of p1asma e nz yme measurements for the early detec t I on of toxIc e f fects. DDMU ndmlnlstratIon may lead to extra hepa tic effects 1 n add It On to those previously described In th e liver. Descriptors: DDT METABOLITE LIVER DAMAGE FATTY LIVER GLUTAMATE OXAL ACETATE TRANS AMINASE GLUTAMATE DEHYDROGENASE SORBITOL DEHYDROGENASE PSEUDO CHOLJN ESTERASE Concept Codes: CYTOLOGY/CYTOCHEM-AN IMAL(02506); BIOCMCM STUD-GENERAL( 10060); BIOCHEM STUD-PROTEI NS,PEPTIOES,AMI NO AC0( 1006-1); BIOCHEM STUD - L I P IDS ( 10066 ) : BIOCHEM STUD - C ARROHYD - R.( 10060); ENZYMES-GEN.COMPAR STUD,COENZYMS( 10802); ENZYMES-C- HEM,PHYSICAL STUDIES(10806); ENZYMES-PHYSIOLOGICAL STUDIES(*1- 0808); PATHOLOGY-GENERAL STUD IES( 12502); PATHOLOGY-DIAGNOST1C - (1250-1): METABOLISM-GENL STUD.METAB PATHW(13002): METABOLISM-- CARB0HY0RATES( * 1300-1 ) ; ME T ABOL l SM - L I P I DS ( * 1 3006 ) ; METABOLISM-- PROTNS.PEPTDS.AM ACDS ( 1 30 1 2 ) : DIGESTIVE S YS T - ANA T OMY ( 1-1002 ) : DIGESTIVE SYST-PATI IOLOGY(* 1A006); BLOOD/BODY FLDS-GENL STUDS.METHSf 15001 ): BLOOD/BODY FLDS-BLOOD.LYMPH STUD(*15002 ) ; DENTAL/ORAL B10L-GENL STUD,METHS(19001): ROUTES OF 1MMUNIZ.INFECT,TITERAP(22100): TOXI COL-GENL/EXP STUDS.METHS(*2- 2501); TOX1 COL -ENVIRONMNTL.INDU5TR(22506): PEST CONTRL GENL/PESTICS/HERBICS(5-1600): ECONOM ENTOMOL-CHEM PHYS CONTRL(60016) Blosystemat1c Codes: ENTOMOLOGY(9G000) GALL I FORMES(85536 ) ; ABSTRACTS OF 690065B 1 THE EFFECTS OF 1 1 DI P CHL0R0PHENYL-2-CHL0R0 ETHYLENE OF PLASMA ENZYMES AND BLOOD CONSTITUENTS IN THE JAPANESE QUAIL COTURNIX-COTURNIX-JAPONICA WESTLAKE G E: BUNYAN P J; STANLEY P I: WALKER C H PEST INFEST. CONTROL LAB.. MINIST. AGRIC. FISH. FOOD, TOLWORTH, SURBITON, SURREY KT6 7NF, ENGL., UK. CHEM-BIOL INTERACT 25 (2-3). 1979. 197-210. Coden: CBINA Language: ENGLISH Glutamate oxaloacetate transaminase (GOT), glutamate dehydrogenase (GDH), sorbitol dehydrogenase (SDH), pseudo-cholinesterase (ChE) and various blood constituents were measured In the plasma of Japanese guaI 1 fed 1,1-d1(p-cliloropheny1)-2-chloroethy1ene (DDMU, a DDT metabolite) at low levels for periods of 2-32 days. DDMU Is a potent Inducer of hepatic microsomal enzymes causing marked structural changes In the liver. A rapid Increase In plasma GOT was observed within A days accompanied by an Increase In relative liver weight. Plasma GDH and SDH Increased to a maximum at 16-24 days which seems to be associated with hepatic cell proliferation. Plasma ChE showed a steady DIALOG FUeS: BIOSIS Previews 77-83/Uan BA7502:RRM2402(See Flle55) (c. BIDSIS 1982) R&S 138456 er 36 14 25j an83 2 102 69006542 DEVELOPMENT OF METHODOLOGIES TO ASSESS THE RELATIVE HAZARDS FROM THERMAL DECOMPOSITION PRODUCTS OF POLYMERIC MATERIALS BARROW C S; LUCIA H; STOCK M F; ALAR IE Y CUEM. IND. INST. TOXICOL.. RESEARCH TRIANGLE PARK. N.C. 27709, USA. AM INO HYG ASSOC J 40 (5). ig79. 408-423. Coden: AI HAA Language: ENGLISH The physiological stress Imposed upon mice due to the Irritating properties of thermal decomposition products of polymeric materials was evaluated. Acute lethality and hIstopatho 1og1ca1 evaluations of the lung. eyes and kidney were included. The rankings of the polymeric materials studied from most of least hazardous was polytetraf1uoroethy 1ene > polyvinyl chloride > Douglas Fir and flexible polyurethane foam > fiber glass reinforced polyester > Cu coated wire with mineral insulation. Descriptors: MOUSE LETHALITY LUNG EYE KIDNEY PATHOLOGY POLY TETRA FLUORO ETHYLENE POLY VINYL CHLORIDE DOUGLAS-FIR POLY URETHANE FIBER GLASS REINFORCED POLY ESTER COPPER COATED WIRE Concept Codes: MICROSCOPY-HISTOL.HISTOCHEM TECH10105G): BIOCIIEM STUD-GENERAL(10060); MINERALS(10069); EXTERN FF-HOT(10618): ANATOMY/HISTOL-MICRO.ULTRAMICRSC(*11108); PAT HOLOGY - NECROS I S ( 1 2 5 1 0 ) : METABOLISM-GENL STUD,METAB PATHW(1300- 2); MINERALS! 13010): URIN SYST/EXT SECR-PATl IDLOGY(* 1 5506 ) ; RESPIRATORY SYST-PATHOLOGY(*16006); SENSE ORGANS-PATHOLOGY(2 - 0006); TOXICOL-GENL/EXP STUDS.METHS(*2250 1 ); TOXI COL-ENVlRONM- NTL.INDUSTR(22506): TEMPERATURE-GENL.METHS(*23001); FORESTRY AND FOREST PRODUCTS(53500) B tosystemat1c Codes: CONIFEROPSI DA (CONI FERAE)(25102); MURIDAE(06375) Concept Codes: GENL BIOL-INSTI TUT.ADM1N.LEGISLN(00508) SOCIAL BIOL/HUMAN ECOLOGY(05500): BIDCHEM STUD - GENERAL( 10060) 81OPHYS-BIOENGINEERING!*10511): PHYS1OLOGY-STRESS(* 12008) ENVIRON HEALTH-OCCUPATNL HEALTH!*370 13) Blosystemat1c Codes: HOMINIDAE(862 I 5) 69005998 STRESSES INVOLVED IN WEARING POLY VINYL CHLORIDE SUPPLIED AIR SUITS A REVIEW RAVEN P B; DODSON A; DAVIS T 0 DEP. PHYSIOL.. N. TEX. STATE UNIV. HEALTH SCI. CENT./TCOM, FT. WORTH. TEX., USA. AM IND HYG ASSOC U 40 (7). 1979. 592-599. Coden: AI HAA Language: ENGLISH A side effect of the growth and development of Industrial technology Is the ever increasing number of hostile environments encountered by man. This situation rosulted In the development of Impermeable clothing as a barrier protection against the external environment. Although specific government standards concerning the design and engineering requirements of the Impermeable suit were stated, little or no standardized evaluation of the majority of available suits was attempted. This review provided an In-depth summary of the physiological effectsof a polyvinyl chloride protective suit while working. It was necessary to develop a standardized performance test to determine the protective and stressful character 1st Ics of the individual manufacturer's designed suit. Recommendations of specific criteria for the test were obtained. Descriptors: HUMAN PROTECTION standards DIALOG F I 1 e5 : BIOSIS Previews 77-83/Jan BA7502:RRM2402(See F11e55) (c. BIOSIS 19 R&S 138457 User 3614 25Jan83 2 103 69002507 .. MUTAGENICITY OF VINYL CHLORIDE VINYLIDENE CHLOROPRENE IN V-79 CHINESE HAMSTER CELLS DREVON C; KUROKI T CHLORIDE AND UNIT CHEM. CARCINOG.. INT, AGENCY RES. CANCER. ALBERT THOMAS. 69372 LYON CEDEX 2, FR. 150 COURS MUTAT RES 67 (2). 1979. Language: ENGLISH 173-182. Coden: MUREA The mutagenicity of vinyl chloride, vinylIdene chldride (1, 1-d1 chioroethy 1ene) and chloroprene (2~ch1oro-1,3-butadlen- e) [Industrial chemicals] was tested In V79 Chinese hamster cells in the presence of a 15,000 .times. g liver supernatant from phenobartaItone-pretreated rats and mice. Mutations In terms of 8-azaguanlne and ouabain resistance were Induced In a dose-related fashion by exposure to vapor of vinyl chlordle In the presence of liver supernatant from phenobarbItono-pretroa- ted rats. Vapors of vinylIdene chloride arid chloroprene Induced a dose-related toxicity In the presence of liver supernatant from phenobarb1 tone-pretreated rats. but these 2 compounds were not mutagenic In V79 Chinese hamster cells under these conditions. The metabolic activation of these compounds and the correlation between their mutagenicity and carcinogenicity dIscussed. In humans and experimental animals were Descriptors: LUNG CELL HUMAN EXPERIMENTAL ANIMAL RAT 'MOUSE LIVER SUPERNATANT PHEND DARBITONE 1 I DI CHLORO ETHYLENE CHLOROPRENE OUABAIN RESISTANCE 8 AZA GUANINE RESISTANCE INDUSTRIAL CHEMICAL CARCINOGENICITY .Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(*02506); CYTOLOGY/C- YT0CHEM-HUMAN(02508); GENETICS/CYTOGENET-ANIMAL(*03506): GENE- TICS/CYTOGENET-HUMAN(*03508): BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-NUCL ACD,PURNS.PYRM(10062); BIOCHEM STUD - STEROLS - .STEROIDS( 10067 ) ; BIOCHEM STUD-CARBOHYOR.( 10060); ENZYMES-MET- HODS(1080-1 ): ENZYME5-PHYSI0L0GICAL STUDIES!10808); PATHOLOGY- -COMPARATIVE! 12503); METABOLISM-GENL STUD.METAR PATHW(* 13002); METAI30LISM-PR0rNS.PEPTDS.AM ACDS(13012): METABOLISM-NUCL ACD , PUR I NS , PYR I M( * 1301-1) ; DIGESTIVE SYST-GENl SUJDS . ME 11 IS ( I 40- 90: DIGESTIVE SYST-PHYS10L ,8I0CHEM( MOO-1 ) : SYST-GENL STUD.METHS!16001); PHARMACOL-DRUG RESPIRATORY ME TAB.METAB ST I MU(22003); PHARMACOL-DIGEST IVE SYST(220 14); ROUTES OF IMMUNIZ,INFECT.THERAP(22lOO); TOXI COL-GENL/EXP STUDS,ME IMS(*2- 2501): TOXICOL-ENVIRONMNTL.INDUSTR(22506); NEOPLSMS/NEOPL AGNTS- CARC lNOGF.NS( *24007 ) ; TISS CU1.TLJRE - APPAR AT . METIIS . MED I A ( 3- 2500): ENVIRON HEALTH-OCCUPATNL HEALTH(37013); PLANT PHYSIOL-CHEM CONST 1TUENTS(51522); PHARMACOGNOSY/PIIARMACEUT BOTANY(54000) Btosystematic Codes: APOCYNACEAE(25580); VERTEBRATA-UNSPECI- FI ED(85150); HOMINIDAE(86215); CRICETI DAE(863 10 ) ; MURIDAE(86375) Language: ENGLISH The method developed to measure transient tnrombus deposition from art.erlal blood on polymeric surfaces Involved Infusion of small amounts of 1251-labeled fibrinogen and 51Cr-labeled platelets into the circulation of anosthetl7od mongrel dog3. Radioactivity adsorbed to the walls of femoral A-V [artery to vein] shunts was counted to measure fibrin and platelet deposition with time following Initial blood-polymer contact. Shunt segments were obtained at each datum for scanning electron microscopy of adhered thrombus material. Plasticized polyvinyl chloride (PVC), recognized as having poor blood compatibility, elicited rapid platelet and fibrin activation resulting In a transient maximum of thrombus deposition after 10-15 min of blood contact. Adherent thrombi subsequently loft the surface. Contact of blood with segmented po1 yetherurethane (BIOMER) resulted In minimal platelet and fibrin deposition. Morphological analysis by EM confirmed these observations. This method can be used to determine the thrombogenlc and embolic potential of polymeric surfaces and may be used to elucidate the mechanisms of artificial surface Induced thrombosis. Descriptors: DOG POLY VINYL CHLORIDE POLY ETHER URETHANE PLATELETS FIBRIN ARTIFICIAL SURFACE INDUCED THROMBOSIS Concept Codes: ELECTRON MlCROSCOPY(01058); CYTOLOGY/CYTOCHE- M-ANIMAL!02506): RADIATION BIOL-RADTN.ISOTOP TECH(06504): BIOCHEM STUD-GENERAL( 10060); BIOCHEM STUD-PROTEI NS,PEPTIDES.A - MINO ACD( 10064): MINERALS( 10069): BIOPHYS-BIOENGINEERING(* 105- it); ANATOMY/HISTOL-MICRO.ULTRAMICRSC!* 11108); CARDIOVASC SYST-BLD VESS PATHOL!* 14508); BLOOD/BODY FLDS-BLOOD.LYMPH STUD!* 15002); BLOOD/BODY FLDS-BLOOD CELL STUDS(*15004); PHARMACOL-NEUROPHARMACOLOGY(22024) B1osystemat1c Codes: CAN1DAE(85765) 69000394 MEASUREMENT OF TRANSIENT THROMBUS DEPOSITION ON POLYMERIC MATERIALS 1HLENFELD J V; MATHIS T R; RIDDLE L M; COOPER S L DEP. CHEM, ENG., UNIV. WIS'. , MADISON. WIS. 53706, USA. THROMB RES 14 (61. 1979 993-968 Ond~,T tmooa DIAL0d^e5: BIOSIS Previews 77-03/Jan BA7502; RRM2402 (See F I I 19062018 SUBCHRONIC TOXICITY OF SOME PIGMENTS ON CADMIUM COMPOUNDS BASIS PREDA N: POPA L; ARIE5AN M; BORDAS E DEP. TOXICOL.. INST. MED. PHARM.. CLUJ-NAPOCA. ROM. 2ND INTERNATIONAL CONGRESS ON TOXICOLOGY. BELGIUM. JULY 6-11, 1980. TOXICOL LETTERS (AMST) ISSUE 1). 1980. 187. Coden; TOLED Language: ENGLISH BRUSSESLS. O (SPEC. Descriptors: ABSTRACT RAT KIDNEY TESTES POLY ETHYLENE POLY VINYL CHLORIDE POLY STYRENE ENZYME CHANGES HI5T0 PATHOLOGY Concept Codes: GENL BIOL-SYMPOSIA,PROCDNGS,REVW(00S20): MICROSCOPY-HISTOL.HISTOCHEM TECH(01056); CYTOLOGY/CYTOCHEM-ANIMAL {02506): COMPARATIVE BIOCHEM-GENL STUDIES(10010); BIOCHEM STUD-GENERALC10060); BIOCHEM STUD-PROTEI NS.PEPTIDES.AMI NO ACD(10064); MINERALS*10069); ENZYMES-GEN.COMPAR STUD,COENZYMS- (10802); ENZYMES-METHODSf 10804 ) ; ENZ YMES - PI IYS I OLOC, I C AL STUD IES(* 10808) ; ANATOMY/HISTOL-MICRO.ULTRAMICRSC( 11108); MET- ABOLISM-GENL STUD,METAB PATl IW( 13002); MlNERALS( 13010); METABOLISM-PROTNS.PEPTDS.AM ACOS(13012); URIN SYST/EXT SECR-GEN STUD .METIK 15501 ) ; U.RIN SYST/EXT SECR - PAT HOLOGY ( * 1550- 6); REPRODUCT SYST-GENL STUDS.METHS( 16501 ); REPRODUCT SYST-PATHOLOGY( 16506) ; TOXI COL-GENL/EXP STUDS.METHS(*22501 ): TOXI COL -ENVIRONMNT L.INDUSTRf22506); ENVIRON HEALTH-AIR.WATR.SL POL LN(37015) B I osys tenia t I c Codes: MUR I DAE (8637 5 ) 19061616 BIOCHEMICAL MODIFICATION OF HUMAN RED BLOOD CELLS PRIOR TO FREEZE. PRESERVATION VALERI C R NAV, BLOOD RES. LAB., BOSTON UNIV. SCH. MED.. 615 ALBANY ST.. BOSTON. MASS. 02118, USA. 16TH ANNUAL MEETING OF THE SOCIETY FOR CRYOBIOLOGY. ATLANTA. GA., USA, OCT. 1-4. 1979, CRYOBIOLOGY 16 (G). 1979 (RECD. 1980). 597. Coden: CRYBA Language: ENGLISH Descriptors: ABSTRACT POLY VINYL CHLORIDE PLASTIC CONTAINER Concept Codes: GENL BIOL*SYMPOSI A.PROCDNGS.REVW(00520); CYTOLOGY/CYTOCHEM-HUMAN(02508); BIOCHEM STUD-GENERAL(10060): EXTERN EFF-COLD(10616); BLOOD/BOOY FLDS-GENL STUDS.METHS(*150- 01): BLOOD/BODY F LDS-BL.000 CELL S TUDS ( * 15004 ) ; TEMPERATURE-GENL.METHSf 23001); TEMPERATURE-CRYOBIOLOGY ( *23004) Btosystemat1c Codes: HOMINIDAE(862 15 ) (c. BIOSIS 198 R&S 138458 Jser 36M 25jan83 2 104 Concept Codes: BIOCHEM mETM-GENERaL(*10050): BIOCHEM STUD-GENERAL( 10060); BIOPMY5 - GENERAL BIOPHYS TECM( * 10504 ) ; T0X1C0L-E NVlRONMNT L.INDUSTR(22506); ENVIRON HE ALTH-OCCUPATNL HEALTH!*37013); ENVI RON HEALTH-A IR.WATR.SL POLLN( 370 15 ) 19060923 MIGRATION OF HARMFUL SUBSTANCES FROM POLY VINYL CHLORIDE MATERIALS USED IN WATER SUPPLY SYSTEMS/ SHEFTEL' V 0: GRINBERG l M ALL-UNION RES. INST. HYG. TOXICOL. PESTIC. POLYM. PLAST.. KIEV, USSR. GIG SANIT O (8). 1979. 78-79. Coden: GISAA Language: RUSSIAN Concept Codes: ECOLOGY-LIMNOLOGY(*075 1 4); ECOLOGY-WATR RESRCM.FISHERY B10L(07517); BIOCHEM STUD-GENERAL( 10060) ; MOVEMENT( 12100); TOXI COL-ENVIRONMNTL.INDUSTR(22506); ENVIRON HEALTH-AIR,WATR.SL POLLN(37015) 19057397 INDUCTION OF PRE NEOPLASTIC FOCI IN RAT LIVER BY HALOGENATED ETHYLENES LAIB R d; BOLT H M; STOECKLE G ART. TOXIKDL., PHARMAKOL. INST.. UNIV.. 0-G500 MAINZ, W. GER. 2 1 ST SPRING MEETING OF THE DEUTSCHE PHARMAKOLOGISCME GESELLSCHAFT (GERMAN PHARMACOLOGICAL SOCIETY), MAINZ, WEST GERMANY. MARCH 18-21, 1980. NAUNYN-SCHMIEOEBERG'S ARCH PHARMACOL 311 (SUPPL.). 1980- R22. Language: ENGLISH Coden: NSAPC Descriptors: ABSTRACT VINYL CHLORIDE VINYL BROMIDE VI NY LI DENE FLUORIDE TRI CHLORO ETHYLENE PER CtILDRO ETHYLENE ATPASE Concept Codes: GENL BIOL-SYMPOSI A,PROCDNGS.REVW(00520 ) : COMPARATIVE BIOCHEM-GENL STUD IES( 10010): BIOCHEM STUD-GENERAL- (10060): BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACD(10064): BIOPHY S-MOLE CUL PROP,MACROMOLEC( 10506); ENZYMCS-PIIYSIOLOGI CAL STUD1ES( 10808): METABOLISM-GENI. STUD.METAB PATHWt * 13002 ) ; DIGESTIVE SYST-PATHOLOGY(* 14006); TOXICOL-GENL/EXP STUDS.METH- S(* 2250 1 ); NEDPLSMS/NEOPL AGNTS-CARCI NOGENS(24007) B losystematic Codes: MURIDAE(86375) 19060950 USE OF CONTINUOUS COULOMETRY TO DETERMINE ORGANO CHLORINE COMPOUNDS IN AN INDUSTRIAL ENVIRONMENT RASPUTNIS .1 I INST. IND.' HYG. OCCUP. DIS.. LENINGRAD. USSR. GIG TR PROF ZABOL O (8). 1979. 56-58. Coden: G T PZ A ' Language: RUSSIAN Descriptors: NOTE CHLORINATED HYDRO CARBONS VINYL CHLORIDE TRI CHLORO ETHYLENE DI CHLORO ETHANE METHYLENE CHLORIDE it DIALOG e5: BIOSIS Previews 77-03/Jan BA7502 ; RRM2402 ( See Flle55) R&S 138459 (c. BIOSIS 1982) (Item 352 ui oao; user 3fa14 25Jan83 2105 19057390 ROLE OF PARENCHYMAL AND NONPARENCHYMAL RAT LIVER CELLS IN THE METABOLISM OF VINYL CHLORIDE OTTENWALDER H: KAPPUS H; BOLT H M MEO. INST. UMWE LTHYG. , UNIV. DUESSELD.. DUESSELOORF. W. GER. 2ND INTERNATIONAL CONGRESS ON TOXICOLOGY, BRUSSESLS, BELGIUM. JULY 6-11, 1980. TOXICOL LETTERS (AMST) 0 (SPEC. ISSUE 1). 1980. 165. Coden; TOLED Language: ENGLISH Descriptors: ABSTRACT TUMOR I GENESIS CARBON-14 NADPM GLUTATHIONE Concept Codes: GENL BIOL -SYMPOSIA,PROCDNGS.REVW(00520); CYT0L6GY/CYT0CHEM-ANIMAL(O25O6); RADIATION BIOL-RAOTN.ISOTOP TECM(06504): BIOCHEM STUO-GENERAL( 10060); BIOCHEM STUD-NUCL ACD,PURNS,PYRM( 10062); BTOCHEM STUD - PROTEI NS.PEPTIDES,AMlNO ACD( 1006A); METABOLISM-GENL STUD.ME TAB PATHW( 13002): METABOLISM-PROTNS.PEPTDS.AM ACDS(13012): METABOLISM-NUCL ACD,PURINS,PYRIM(13014); DIGESTIVE SYST-GENL STUDS,METIIS(1400- 1): DIGESTIVE SYST-PATHOLOGY(* 14006); TOXI COL-GENL/EXP STUDS,METHS(*22501); TOXI COL-ENVIRONMNTL,INDUSTR(22506): NEOP- LSMS/NEOPL AGNTS-CARC1N0GENS(*24007); ENVIRON HEALTH-AIR.WATR- ,SL POLLN(37015) B losystematIc Codes: MURIOAE(86375) 19057356 IMMUNOLOGICAL EFFECTS OF VINYL CHLORIDE IN MICE SHARMA R P; GEHRING P J TOXICOL. PROGRAM. UTAH-STATE UNIV.. LOGAN. UTAH 84322, USA. NICHOLSON. W. J. AND J. A, MOORE (ED.). ANNALS OF THE NEW YORK ACAOEMY OF SCIENCES, VOL. 320. HEALTH EFFECTS OF HALOGENATED- AROMATIC HYDROCARBONS; INTERNATIONAL SYMPOSIUM. NEW YORK, N.Y.. USA. JUNE 24-27, 1978, X+730P. NEW YORK ACADEMY OF SCIENCES: NEW YORK. N.Y., USA. II.LUS. MAPS. PAPER. ISBN 0-89766-008-0. O (0). 1979 (RECD. 1980). P551-563. Coden: ANYAA Language: ENGLISH Descriptors: HUMAN WORKER COMPARISON CARCINOGENESIS Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS.REVW(00520); BIOCHEM STUD-GENERAL(10060): PATHOLOGY-COMPARATIVE(12503); METABOLISM-GENL STUD,METAB PATHW( 13002); TOXI COL-GENL/EXP STUDS.METHS(*22501 ): TOXI COL-ENVIRONMNTL. INDUSTR(22506); NEOP- LSMS/NEOPL AGNTS-CARCINOGENS(*24007): IMMUNOL/IMMUNOCMEM-GEN METH(34502); IMMUNOL/IMMUNOCHEM-IMMUNOPATHOL(34508): ENVIRnN HEALTH-OCCUPA TNL HEALTH(37013); ENVIRON HEALIII-A IR.WAIR.SL POL LN(37015) B losystematIc Codes: IIOMINIDAE(86215); MURIOAE(86375) GESELLSCHAFT (GERMAN PHARMACOLOGICAL SOCIETY), MAINZ. WEST GERMANY. MARCH 18`21. 1900. NAUNYN-SCUMlEDEBERG'S ARCH PHARMACOL 311 (SUPPL.). 1980. R23. Coden: NSAPC Language: ENGLISH Descriptors: ABSTRACT SACCHAROMYCES-CEREVISI AE RAT LIVER MICROSOMES TRYPTOPHAN PROTOTROPH Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS,REVW(00520): CYTOLOGY/CYTOCHEM-ANIMAL(02506); GENETICS/CYTOGENET-ANIMAL(*03506): COMPARATIVE BIOCHEM-GENL STUDIES(10010); BIOCHEM STUD-GENERAL(10060): BIOCHEM STUD-PROTEINS.PEPTIDES,AMINO ACD(10064); BIOPHYS-MOLECUL PROP.MACROMOLEC( 10506); METABOLISM-GENL STUD.METAB PATHW(*130- 02); METABOLISM-PROTNS.PEPTDS.AM ACDS(13012); DIGESTIVE SYST-PATHOLOGY! 14006); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(240- 07); IN VITRO STUDS-CELLULR.SUBCELL(32600): MED/CLIN MI CROC IOL-GEN.METH,TECH(36001): MED/CUN MICROBIOL- MYCOLOGY(* - 36000); PLANT PHYSIOL-CHEM CONST ITUENTS(5 1 522 ) Blosystemat1c Codes: ASCOMYCETES( 15100); MUR IOAE(8637 5) 19047510 CONSIDERATIONS IN THE, DECISION OF THE SWEDISH OCCUPATIONAL HEALTH STANDARD FOR VINYL CHLORIDE MONOMER HOLMBERG B; WE ST L1N A NAIL, BOARD OCCUP. SAF . HEALTH, ' ARBE TARSK YDDS ST YRE 1. SEN. FACK, S-100 2G STOCKHOLM. SWEO. HAMMOND, E. C. AND I. J. SELIKOFF (F.O.). ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, VOL. 329, PUBLIC CONTROL OF ENVIRONMENTAL HEALTH HAZARDS; INTERNATIONAL CONFERENCE. NEW YORK. N.Y., USA, JUNE 28-30. 1978. IX+405P. NEW YORK ACADEMY OF SCIENCES: NEW YORK. N.Y., USA. ILLUS. MAPS. PAPER. ISBN 0-89766-031-5. 0 (0). 1979 (RECD. 1980). P201-206. Coden: ANYAA Language: ENGLISH Descriptors: HUMAN ANIMAL CARCINOGEN Concept Codes: GENL 0 IOL-SYMPOSI A.PROCDNGS.REVW(00520 ) : SOCIAL BIOL/HUMAN ECOLOGY(05500); BIOCHEM STUD-GENERAL(100601: PATMOLOGY-COMPARATIVE( 12503); METABOLISM-GENL S T UO,ME T AB P A T HW( 13002); TOXI COL-ENV1RONMNTL,INDUSTR(*22506); NEOPLSMS/N- EOPL AGNTS-CARCI NOGENS(24007); ENVIRON HEALTHOCCUPATNL HEALTHf *37013) ; ENVIRON HEALTH-A I R . WATR . SL P0l.LN(37O15) BloSystomatIc Codes: VERTEBRATA-UNSPEC1FIEO(85150): HOMINID- AE(86215 > 19055715 MUTAGENICITY OF VINYL CHLORIDE IN-VITRO AND IN-VIVO WITH YEAST AS INDICATOR ORGANISM ECKARDT F: OE RUI TER N; OTTENWAELDER H ABT. PHARMAKOL., MED. INST. UMWE LTHYG. , UNIV. DUESSELDORF. GURLITTSTR. 53, D-4000 DUSSELDORF 1, W. GER. 21 ST SPRING MEETING OF THE DEUTSCHE pilUBMAXm nnicrur DIALOG F11e5: BIOSIS Previews 77-83/Jan BA7502;RRM2402(See F11e55) (c. BIOSIS 1992) (Item R&S 138460 lS J an83 2106 19047509 INTERNATIONAL DIFFERENCES IN DECISION MAKING ON ENVIRONMENTAL CONTROLS CASE STUDY VINYL CHLORIDE DUNCAN K P LONDON W2 4TF, ENGL.. UK, HAMMOND, E. C. AND I. J. SELIKOFF (ED.). ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. VOL, 329. PUBLIC CONTROL OF ENVIRONMENTAL HEALTH HAZARDS INTERNATIONAL CONFERENCE. NEW YORK, N.Y.. USA. JUNE 28-30. 197B. IX+405P. NEW YORK ACADEMY OF SCIENCES: NEW YORK. N.Y.. USA. ILLUS. MAPS. PAPER. ISBN 0-89766-031-5. ANYAA 0 (0). 1979 (RECD. 1980). P 1 8 3 - 187 . Coden: Language: ENGLISH Descriptors: HUMAN VINYL CHLORIDE CARCINOGEN LEGISLATION Concept Codes: GENL BIOL-INST I TUT.ADMIN.LEG ISLN(00508); GENL BI0L-SYMP05IA,PROCDNGS.REVW(00520); BIOCHEM STUD-GENERAL- (10060); METABOLISM-GENL STUD,METAB PATHW( 13002); TOXICOL-ENV- IRONMNTL. INOUSTR(+22606); NEOPLSMS/NEOPL AGNTS-CARC I NOGENS(*2- 4007);- ENVIRON HEALTH-OCCUPATNL HEALTH(37013); ENVIRON HEALTH-AIR.WATR.SL P0LLN(37015) B losystemat1c Codes: HOMINIDAE(86215) 19044448 FASTENING OF HIVES WITH POLY VINYL CHLORIDE SAFE TRANSPORTATION GALLARATO B HARNAJ. V. L'API CULTURE INDUSTRIELLE; INTERNATIONAL. BUCAREST AND TULCEA. AOUT. SYMPOSIUM 16-24. 1978 (INDUSTRIAL APICULTURE: INTERNATIONAL SYMPOSIUM, BUCHAREST AND TULCEA. ROMANIA, AUG. 16-24, 1978). 184P. EDITIONS APIMONDIA: BUCHAREST. ROMANIA. ILLUS. Coden: 08632 Language: FRENCH Descriptors: HONEY FLOW PAPER. O (O). 1979. P145-147. Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS.REVW(00520); BIOCHEM STUD-CARBOHYDR.(10068): FOOD TECH-SUGAR(+13524); ECONOM ENTOMOL-API CULTURE!*60018) Blosystemat1c Codes: HYMENOPTERA(75326) CELL STUDSt 15004); BONE.JNTS.FASC.CONN/AD IP-PATHOL( * 18006 ) : INTEGUMENT SYST-PATHOLOGY(18506): PHARMACOL - GENERAL STUD IE S t - 22002): PHARMACOL-CLINICAL PHARMACOL(22005); TOXI COL-GENL/EXP STUDS.METHS(+22501); TOXICOL-PHARMACOLOGI CAL(22504 ); TOXICOL - ENVIRONMNTL.INDUSTR(22506); IMMUNOL/IMMUNOCHEM-IMMUNOPATHOL(+34508); ENVIRON HEALTH-AIR.W- ATR.SL P0LLN(37015): CHEMOTHERAPY-GEN STUD.METH.METAB(38502) Blosystemattc Codes: HOM1NIDAE(86215) 19042517 FASCIITIS AND FIBROSIS LYNCH M; JAYSON M I V RHEUM. RES. CENT.. R. INFIRM., MANCHESTER, ENGL., UK. CLIN RHEUM DIS 5 (3), 1979 (RECD. 1980). 833-856. Coden: CRHDD Language; ENGLISH Descriptors: REVIEW HUMAN INFLAMMATION COLLAGEN DUPUYTRENS DISEASE PEYRONIES DISEASE DRUG INDUCED PULMONARY FIBROSIS VINYL CHLORIDE DISEASE EOSINOPHILIC FASCIITIS SYSTEMIC SCLEROSIS Concept Codes: BIOCHEM STUO-PRDTE INS.PEPTIDES.AMINO AC.O( 10064); CIIORDM E BODY REGNS-E XTREM1T1ES( 1 13 10) : PATHOLOGY-INFLAMMATN.INFLAM DIS(*12508); MET ABOLISM-PROTNS.PE - PTDS.AM ACDS( 130(2): BLOOO/BOOY FLOS-BLD,LYM ,RES PATH(* 15006); RESPIRATORY SYST-PATHOLOGY(*16006); REPRODUC T SYST- PATHOLOGY(- + 1G506): MUSCLE SY5T-PATHOLOGY( +17506 ) ; BONE .JNTS.FASC.CONN/A- DIP-PATHOL(* 18006): TOXICOL-PHARMACOLOGICAL( *22504 ); TOXI COL - - ENVIRONMNTL,INDUSTR(*22506): ENVIRON HEALTH- OCCUPATNL HEALTIU - 37013) B losystematIC Codes: H0MINIDAE(86215) 19042519 CLASSIFICATION AND NOMENCLATURE OF PROGRESSIVE SYSTEMIC SCLEROSIS SCLERODERMA RODNAN G P; JABLONSKA S; MEOSGER T A JR DEP. MED., UNIV. PITTSB. 5CH, MED., PITTSBURGH, PA., USA. CLIN RHEUM 01S 5 (1). 1979. S-14. Codec: CRHOD Language: ENGLISH Descriptors: HUMAN POLY VINYL CHLORIDE DISEASE TRI CIII.ORO ETHY1LNE INDUCED SCLERODERMA BLEOMYCIN INDUCED riBROSIS EOSINOPHILS FASCIITIS PROGRESSIVE SYSTEMIC SCl.EROSIS MORPHEA Concept Codes: GENL B1OL-TAXONOMY,NOMENCLATUR(00504): CYTOI.OGY/CYTOCHEM-I IUMAN (0250B ) ; BIOCHEM STUD-GENERAL ( 10060): BIOCHEM STUD-PROTEINS.PEPTIDES,AMINO ACO{10064); BIOCHEM STUD-CARBOHYDR. (-10068): PM,,n| Mlrt PATHOLOGY-GENERAL STUD IES(* 12502): ~r-w. f................... R&5^J 38461 reviews 77-03/Jan BA7502;RRM2402 ( See Fll 19037175 CARCINOGENIC RISK OF PRODUCTS USED IN THE PHARMACEUTICAL AND RELATED INDUSTRIES COUSTOU F UNIV. BORO. II, BORDEAUX, FR. DAVIS. W. AND C. R05ENFELD (ED.). IARC (INTERNATIONAL AGENCY FOR RESEARCH ON CANCER) SCIENTIFIC PUBLICATIONS. NO. 25. INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) SYMPOSIUM SERIES. VOL. 74. CARCINOGENIC RISKS: STRATEGIES FOR INTERVENTION: PROCEEDINGS OF A SYMPOSIUM, LYON. FRANCE. NOV. 30-DEC. 2, 1977. XV+283P. INTERNATIONAL AGENCY FOR RESEARCH ON CANCER: LYON, FRANCE. ILLUS. ISBN 92-832-1125- 1; ISBN 2-85598-181-G. Coden: IARCC 0 (O). 1979. P129-150. Language: ENGLISH Descriptors: HUMAN HEALTH VINYL CHLORIDE MONOMER ANILINE DYES ARTIFICIAL SWEETENERS ASBESTOS AFLA TOXIN CARCINOGEN FOOD OCCUPATIONAL HAZARD Concept Codes: GENL BlOL-SYMPOSI A.PROCDNGS.REVW{00520); BIOCHEM STUD-GENERAL( 10060); MINERALS( 10069); NUTRITI ON-PATHO- GENIC DIET5( 13216); PHARMACOL-GENERAL STUD IES(22002): TOXICOL-FOOD.RESIDS,ADDIT,PRESRV(*22502): TOXICOL-PHARMACOLOGICAL(*22504); TOXICOL -ENVIRONMNT L,INDUSTR(*22506); NEOPLSMS/NCOPL AGNTS-CAR- CINOGENS(*24007); MED/CLIN MICROBIOL-MYCOLOGY(3G00B); ENVIRON HEALTH-OCCUPATNL HEALTHf*37013): FOOD/INDUS MICRO-FD/BEV SP CNTAM(39002); PLANT PHY5I0L-CHEM CONST ITUENTS(51522) BlosystomatIc Codes: OEUTEROMYCETESf 15500); HOMINIDAE(86215) 19037169 ASSESSMENT CARCINOGEN ' OF TRI CHLORO ETHYLENE AS AN OCCUPATIONAL PAGE N N PRIOR. RES. ANAL. BRANCH. NATL. INST. OCCUP. 5AF. HEALTH, ROCKVILLE, MO., USA. DAVIS. W. AND C. ROSENFELO (ED.). IARC (INTERNATIONAL AGENCY FOR RESEARCH ON CANCER) SCIENTIFIC PUBLICATIONS. NO. 25. INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) SYMPOSIUM SERIES, VOL. 74. CARCINOGENIC RISKS: STRATEGIES FOR INTERVENTION; PROCEEDINGS OF A SYMPOSIUM. LYON. FRANCE, NOV. 30-DEC. 2, 1977. XV+283P. INTERNATIONAL AGENCY FOR RESEARCH ON CANCER: LYON, FRANCE. ILLUS. ISBN 92-832-1125-1: ISBN 2-85598-181-6. Coden: IARCC 0 (0). 1979. P75-80. Language: ENGLISH Descriptors: MOUSE RAT HUMAN VINYL CHLORIDE CARCINOGEN EPOXIDE METABOLITE Concept Codes: GENL B1OL-SYMPOSI A.PROCDNGS.REVW(00520) ; COMPARATIVE BIOCHEM-GENL STUD IES( 10010): BIOCHEM STUD-GENERAL- (100G0); METAGOLISM-GENL SFUD.METAB PATHW(13002): TOXICOL-ENVIRONMNTL.INDIJSTR(* 22506); NE0PL5MS/NE0PL AGNTS-CAR- CIN0GENS(*24007); ENVIRON HEALTH-OCCUPATNL HEALTH(* 37013) Blosystemat1c Codes: HOMINIDAE(86215); MUR IOAE(86375) (c. BIOSIS 1982) (Item 360 of 858) User 3614 25Jon83 2107 19035785 AN ACQUIRED RED CELL ANTIGEN DERIVED TROM POLY VINYL CHLORIDE BLOOD PACKS BRUCE M; CRAWroRD R d; MITCHELL R; GILES C M GLASG, AND W. SCOTL. BLOOD TRANSFU5. SERV.. LAW HOSP.. CARLUKE. LANARKSHIRE ML8 5ES, SCOTL.. UK. MED LAB SCI 37 (2). 19B0. 171-172. Codcn; MLASD Language: ENGLISH Descriptors: NOTE HUMAN TOXICITY Concept Codes: CYTOLOGY/CYTOCHEM-HUMAN(0250B): BIOCHEM STUD-GENERAl.( 10060); BLOOO/BODY FLOS-GENL STUDS.METHS(*1500 1 ); BLOOO/BOOY FLDS-BLOOD CELL STUDS(*15004); TOXI COL-GENL/EXP STUDS.METHS(*22501): IMMUNOL/IMMUNOCHEM-IMMUNOHEMATOL(*34506) Blosystewat1c Codes: H0M1NIDAE(8G215) 19035413 UTILIZATION OF THE CHINESE HAMSTER OVARY CELL HYPO XANTHINE GUANINE PMOSPHO RIBOSYL TRANSFERASE SYSTEM METABOLIC ACTIVATION AND METHOD FOR TESTING GASES KRAHN D F HASKELL LAB. TOXICOL. IND. MED., E.I. DU PONT DE NEMOURS CO.. WILMINGTON. DEL. 19898, USA. HSIE. A. W., J. P. O'NEILL AND V. K. MCELHENY (ED.). BANBURY REPORT, 2. MAMMALIAN CELL MUTAGENESIS: THE MATURATION OF TEST SYSTEMS: PROCEEDINGS OF A MEETING. MAY 1979. XIV+504P. COLD SPRING HARBOR LABORATORY: COLO SPRING HARBOR. N.Y.. USA. ILLUS. ISBN 0-87969-201-4. O (0). 1979 (RECD. 1980). P251-262. Coden: BANRO Language: ENGLISH Descriptors: CHLOROFLUORO METHANE TRI CHLOROFLUORO METHANE VINYL CHLORIDE DI CHLORODIFLUORO METHANE CHLOROFLUORO METHANE MUTAGEN CYTO TOXICITY Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS.REVW(00520): CYTOLOGY/CYTOCHEM-ANIMALt *02506): GENET1CS/CY70GENET-ANIMAL(*03506); BIOCHEM-GASES( 10O12); BIOC HEM STUD-GENERAL( 10060); BIOCHEM STUD-NUCL ACD.PURNS.PYRM( ioo- 62); BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACD(10064); ENZYMES-PHYSIOLOGICAL STUD IES(* 10808); PATHOLOGY-NECROS I S( 125- 10): METABOLISM-PROTNS.PEPTDS,AM ACDS(13012); METABOLISM-NIJCL ACD.PURINS.PYRIM(* 13014): REPRODUCT SYST-GENL STUDS.METHS( 165- 01): TOXICOL-GENL/EXP STUDS.METHS(*22501); TISS CULTURE - APPAR - AT.METHS.MEDIA(32500); IN VITRO STUDS-CELLULR.SUBCELL(32600) B I osyStematIc Codes: CRICETI DAE(86310) DIALOG FlleS: R&S 138462 Jan BA7502;RRM2402(See FlleSS) (o'. BIOSIS 1982 ) (Item 364 of 850) User 3614 25Jnn83 2 100 1903069 I PROBLEM OF VINYL CHLORIDE HAZARD IN CONNECTION WITH HYGIENIC ASPECTS OF THE USE OF POLY VINYL CHLORIDE MATERIALS OYUBANKOVA E N; BYKHOVSKII A V F.F. ERISMAN M05C. RES. INST. HYG., MOSCOW, USSR. GIG SANIT 0 (1). 1979. 69-74. Coden: GISAA Language: RUSSIAN Descriptors: CHILD FOOD WRAPPER GENETICS Concept Codes: GENETICS/CYT0GENET-HUMAN(03508); SOCIAL BIOL/HUMAN ECOLOGY(05500): BIOCHEM STUD-GENERAL(10060): METABOUSM-GENL STUD,METAB PATHW(13002); FOOD TECH-PREP.PROCE- SSNG,STORAGE! 13532); TOXICOL-GENL/EXP STUDS,METHS(* 22501}: TOXICOL-FOOD,RESI OS.ADO IT,PRESRV(+22502); TOXICOL * ENVIRONMNTL,INDUSTR(22506); PEDIATRICS(25000): ENVIRON HEALTH-OCCUPATNL HEALTH(37013): POLLNf 370 15) ENVIRON HEALTH-AIR,WATR.SL B1osystemat 1 c Codes: HOMINIDAE(B6215) 19030550 ACUTE MORTALITY DUE TO INHALATION OF THERMAL DECOMPOSITION PRODUCTS OF SYNTHETIC AND NATURAL POLYMERS ANDERSON R C; ALAR IE Y DEP. IND. ENVIRON. HEALTH SCI., GSPH, UNIV. PITTSB., PITTSBURGH. PA. 152G1. USA. 1BTH ANNUAL MEETING OF THE SOCIETY OF TOXICOLOGY, NEW ORLEANS, LA., USA. MAR. 11-15. 1979. TOXICOL APPL PHARMACOL 4a-(l PART 2). 1979. A5. Coden: TXAPA Language: ENGLISH Descriptors: ABSTRACT MOUSE DOUGLAS-FIR POLY TETRA FLUORO ETHYLENE POLY CARBONATE POLY VINYL CHLORIDE POLY URETHANE FOAM POLY STYRENE FOAM FIBERGLASS REINFORCED POLY ESTER Concept Codes: GENL BIOL-SYMPOSI A,PROCDNGS.REVW(00520): BIOCHEM STUD-GENERAL(10060); EXTERN EFF-HOT(+10618); PATHOLOGY-NECROSIS!12510); RESPIRATORY SYST-GENL STUD,METHS(1 - 6001): ROUTES OF IMMUNIZ,INFECT.THERAP(22100); TOXICOL-GENL/E - XP STUDS,METHS!+22501); TOXI COL-ENVIRONMNTL.INOUSTR(22506); TEMPERATURE-GENL,METHS(23001); FORESTRY AND FOREST PRODUCTS(53500) B 1 osys tema 11 c Codes: CONI F EROPSI DA (CON I F ERAE ). ( 25 102 ); MURIDAE(06375) 19029809 HYGIENIC ASSESSMENT OF PROCESSES OF HIGH TEMPERATURE TREATMENT OF POLY VINYL CHLORIDE FINISHING MATERIALS ZOLKIN G A ALL-UNION RES. INST. CONSTR. IND.. OFF. ST AIE CONSTR. USSR. MOSCOW, USSR.' GIG SANI.T 0 (4). 1979. 76-77. Coden: GISAA Language: RUSSIAN Descriptors: VINYL CHLORIDE HYDROGEN CHLORIDE CARBON MON OXIDE HYDRO CARBONS MAXIMUM PERMISSIBLE CONCENTRATION Concept Codes: GENL BIOL-INSTI TUT,ADMIN.LEG ISLN!00508); BIOCHEM-GASES(10012); BIOCHEM STUD-GENERAL(10060); EXTERN URE-GENL . METHS! 2300 1 ) : ENVIRON HE AL III - OCCIJP A T NL HE A L TIU 3 70 I3) 19028465 INSULIN KINETICS WITH INTRA VENOUS HYPER ALIMENTATION IN POLY VINYL CHLORIDE AND GLASS CONTAINERS COWAN G S M JR CLIN. INVEST. SVC.. D.D. EISENHOWER ARMY MED CENT.. F T GORDON. GA. 30905. USA. 64 TH ANNUAL MEETING OF THE FED. AM. SOC . EXP. BI OL . ANAHEIM . CALIF.. USA, APR. 13-18, 1980. FED PROC 39 (3) 1980. ABSTRACT 4460. Coden : FEPRA Language: ENGLISH Descriptors'. ABSTRACT HUMAN Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS,REVW(00520) : RADIATION BIOL-RADTN, ISOTOP TECH(06504 ); CLIN BIOCHEM-C.ENL STUDIES! 10006); BIOCHEM STUD-GENERAL( 10060) ; BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACO(10064); METABOLISM-PROTNS.PE- PTOS.AM ACDS(+ 13012); NUTRITION-GENL.NUTR STATUS.METHS( 13202 ) CAROIOVASC SYST-GENL STUDS,METHS(14501): PHARMACOL-DRUG METAB.METAB STIMU(+22003); PHARMACOL-ENDOCRINE SYST(220 1 6 ) : ROUTES or IMMUNIZ.INFECT.THERAP(22100) Btosystemattc Codes: HOMINI DAE(86215). 19026946 VINYL CHLORIDE UBIQUITOUS CARCINOGEN LINGEMAN C H NATL. CANCER INST,, BETHESDA, MD. 20014. USA. NIELSEN, S. w. , G. MIGAKI AND D. G. SCARPELLI (ED.). ANIMALS AS MONITORS OF ENVIRONMENTAL POLLUTANTS: SYMPOSIUM. STORRS. CONN.. USA. 1977. XII+421P. NATIONAL ACADEMY OF SCIENCES: WASHINGTON. D.C., USA. ILLUS. MAPS. PAPER. ISBN O-309-02871 -X. 0 (0). 1979 (RECD. 1980). P391-392. Coden: 08582 Language: ENGLISH Descriptors; ABSTRACT MOUSE RAT HAMSTER HUMAN ANIMAL DEATH HEM ANGIO SARCOMA FIBROSIS Concept Codes: GENL BIOL-SYMPOSI A,PROCDNGS.REvw(00520 ) : PATHOLOGY-NECROSIS( 12510): BLOOD/BOOY FLDS"GENL STUDS.METHS( 1 5001); BLOOO/BOOY FLDS-BLO,LYM,RES PATH(+15006): TOXI COL-GENL- /EXP STUDS.METHS!*22501); TOXI COL-ENVIRONMNTL. INDUSTR(22506 ) ; NEOPLSMS/NEOPL AGNTS-CARCINOGENS!+24007); NEOPLSMS/NEOPL AC.NTS-BLOOD.RES!+24010) ; ENVIRON HE ALTH-A I R . WAT R . SL P0LLN(370- 15) B losystemat1c Codes: ANIMALI A-UNSPECIFI ED(33000); HOMINIDAE- (86215); CRICETI0AE(8G310); MUR IOAE(86375) OIALO e5: B&S 138463 'an BA7502;RRM2402(Soe Fil 19026930 THE METABOLIC ACTIVATION OF CHEMICAL CARCINOGENS SIMS P DIV. CHEM.. CHESTER BEATTY RES. INST., R. CANCER HOSP,. LONDON, ENGL., UK. BR MED BULL 36 (1). 1980. Language: ENGLISH 11-10. Coden: BMBUA Descriptors: REVIEW RAT LIVER AFLA TOXIN B-1 SAFROLE NAPHTHALENE BENZO A PYRENE 2 ACETYLAMINO FLUORENE DI METHYL NITROSAMINE VINYL CHLORIDE EPOXIDE HYDRATASE GLUCURONYL TRANSFERASES SULFO TRANSFERASES MONO OXYGENASES Concept Codes: BIOCHEM STUD-GENERAL(10060); BIOCHEM 5TUD-PR0TEINS,PEPTIDES,AMINO ACD(10064): ENZYMES-PHYSIOLOGICAL STUDIES!*1OBO0); METABOLISM-GENL STUD,ME T AB PATHW(* 13002): DIGESTIVE SYST-PHYSIOL.BIOCHEM( 14004); TOXI COL-GENL/EXP STUDS,METHS(*22501): NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(*24007); MED/CLIN MICROBIOL-MYCDLOGYf 36008): PLANT C0NSTITUENTS(51522); AGRONOMY-OIL CR0PS(52514) PHYSIOL-CHEM Blosystemat Ic Codes: DEUTEROMYCETES(15500); ANGIOSPERMAE-UN SPECIFIED ( 25200 ) : MURIDAE(86375) 19020375 THE EFFECTS OF TOTI GESTATIONAL EXPOSURE TO ETHCHLORVYNOL ON DEVELOPMENT AND BEHAVIOR PETERS M A; HUDSON P M PHARMACOL. DEP., SCH. MED., LOMA LINDA UNIV., LOMA LINDA. CALIF. 92350, USA. 64TH ANNUAL MEETING OF THE FED. AM. SOC. EXP. BIOL.. ANAHEIM. CALIF., USA. APR. 13-10, 1980. FED PROC 39 (3). 1980, ABSTRACT 4042. Coded: FEPRA Language: ENGLISH Descriptors: ABSTRACT VINYL CHLORIDE OFFSPRING Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS,REVW(00520): BEHAVIOR BIOL-ANIMAL BEHAVIOR(*07003); BIOCHEM STUD-GENERAL( 1- 0060); PHYSIOLOGY-GENERAL STUD IESC12002); PATHOLOGY-GENERAL STUD1ES(12502); REPRODUCT SYST-PHYSIOL.BIOCHEM(16504); NERVOUS SYST-PATHOLOGY(*20506); TOXI COL-GENL/EXP STUDS,METHS(*22501): TOXICOL-ENVIRONMNTL.INDUSTR(22506); DEVELOPMNTL BIOL-PATHOLOG- ICAL(*25503); DEVELOPMNTL BIOL-EXPERIMENTAL(*25504) Blosystemat1c Codes: VERTEBRATA-UNSPECIFI ED(05150) 19020288 TRANS MEMBRANE ALKYLATION A NEW METHOD FOR STUDYING IRREVERSIBLE BINDING OF REACTIVE METABOLITES TO NUCLEIC-ACIDS LA IB R d; BOLT H M ABT. TOXIKOL., PHARMAKOL. INST., UNIV., OBERE ZAHLBACHER STR. 67. D-6500 MAINZ. W. GER. BIOCHEM PHARMACOL 29 (3). 1980. 449-452. Coden: BCPC.A Language: ENGLISH Descriptors: NOTE RAT LIVER MICROSOMES VINYL CHLORIDE POLY ADENYLIC-ACID 1-N-6 ETHENO ADENOSINE Concept Codes: CYTOLOGY/CYTOCHEM-AN IMAL(02506) ; BIOCHEM STUD-GENERAU10060); BIOCHEM STUD-NUCL ACO,PURNS,PYRM(10062): METABOLISM-GENL STUD,ME T AB PATHW(13002): DIGESTIVE (c. B10SIS 1982) (Item 369 of 858) User 3614 25JanB3 2109 SYST-PHYSIOL .BIOCIIEMf 14004 ) ; PHARMACOL - DRUG ME1AB.ME1AB STIMU( *22003); TOXICOL-GENL/EXP STUOS.METHS( 2250 1 ) B(osystematIc Codos; MUR I DAE(06375 ) 19016257 THE COMPARATIVE EFFECTS OF AGE OF AN ANIMAL AT TIME OF EXPOSURE AND EXPOSURE DURATION ON VINYL CHLORIDE CARCINOGENESIS BOORMAN G A; MCCONNELL E E; COCKRELL B Y; DREW R T; STONE C U: HASEMAN d K; MOORE d A NATL. INST. ENVIRON. HEALTH SCI., P.O. BOX 12233. RESEARCH TRIANGLE PARK. N.C. 27709. USA, 64ri-l ANNUAL MEETING OF. THE FED. AM. SOC. EXP. BIOL.. ANAHEIM. CALIF., USA. APR. 13-18. 1900. FED PROC 39 (3). 1980. ABSTRACT 1481. Coden: FEPRA Language: ENGLISH Descriptors: ABSTRACT GOLDEN SYRIAN HAMSTER RAT MOUSE CARCINOGEN HEM ANGIO SARCOMA SKIN TUMOR NONGLANDULAR STOMACH TUMOR MAMMARY TUMOR HEPATO CELLULAR TUMOR Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS.REVW(00520); CYTOLOGY/CYT OCHEM-HUMAN(02508); BIOCHEM STUD-GENERAL( 10060); DIGESTIVE SYST-PATHOLOGY(14006); CARDIOVASC SYST-BLD VESS PATHOL(* 14508); REPRODUCT SYST-PATHOLOGY(*16506); INTEGUMENT SYST-PATHOLOGY!* 18 506); TOXICOL-GENL/EXP STUDS.METHS(*2250 1); NEOPLSMS/NEOPL AC.NTS-CARC I NOGENS (* 24007 ) B losystematIc Codos: CRICETIDAE(86310); MUR I DAE(86375 ) 19016210 FORMATION AND INACTIVATION OF A REACTIVE METABOLITE OF VINYL CHLORIDE PESSAYRE O: WANDSCHEER d-C; ARTIGOU d-Y; OESCATOIRE V; DEGOTT C; BENHAMOU d-P UNITE RECH. PHYIOPATHOL. HEPATIOUE, INST. NATL. SANTE RECH. MED., HOP. BEAUdQN. F-92110 CLICHY. FR. 14TH FORUM OF RESEARCH OF THE FRENCH NATIONAL SOCIETY OF GASTROENTEROLOGY AND 6TH MEETING OF THE FRENCH ASSOCIATION FOR STUDY OF THE LIVER, TOULOUSE, FRANCE. OCT. 13-14, 1978. GASTROENTEROL CLIN BIOL 3 ( 1 ). 1979. 1O0. Coden: GCB10 Language: FRENCFI Descriptors: ABSTRACT HUMAN CARCINOGEN HEPATO TOXIC CYTOCHROME P-450 Concept Codes: GENL BIOL-SYMPOSI A,PROCDNGS,REVW<00520); BIOCHEM STUD-GENERAL( 10060); BIOCHEM STUD-PROTEI NS.PEPTIOES . A- MINO ACD( 10064); BIOCHEM STUD-PORPHYRNS.BILE PIGM(IOOGS): ENZYMES-GEN,COMPAR 5TUD,COENZYMS!*10B02); METABOLISM-GENL STUD.METAB PATHW(* 13002); DIGESTIVE SYST-PATHOLOGY(14006 ) ; TOXICOL-GENL/EXP STUOS,METHS(* 22501); NEOPLSMS/NEOPL AGNTS-CA- RCINOGENS(*24007) Blosystemnt Ic Codes: VERTEBRATA-UNSPECIFIEO(85 I 50) DIALOG Flle5: BIOSIS F R&S 138464 '2 ; RRM2402 ( See F I le55) (c. BIOSIS 1982) (Item 374 of 858) User 3614 25jan83 2 110 19009595 THE NATURE AND FREQUENCY OF SLEEP DISORDERS IN PERSONS EXPOSED TO THE EFFECT OF VINYL CHLORIDE DURING WORK GNESINA E A; ANTONYUZHENKO V A; MASHIKHIN E N; ROSTOVTSEVA G G INST. IND. HYG. OCCUR. OIS., GORKI. USSR. GIG TR PROF ZABOL Coden: GTPZA 0 (11). 1970 (RECD, 1979). 16-19. Language: RUSSIAN Descriptors: DYSSOMNIA ELECTRO ENCEPHALOGRAPHY Concept Codes: SOCIAL BIOL/HUMAN ECOLOGY(05500): BEHAVIOR BIOL-HUMAN BEHAVI OR(07004); BIOCHEM STUD-GENERAL( 10OGO): BIOPHYS-GENERAL BIOPHYS TECH( 10504); PATHOLOGY-DIAGNOSTIC( I 25- 04); ME T ABOLISM-GENL STUD.METAB PATHWl 13002); NERVOUS SY5T-GENL STUDS.METHS(20501): NERVOUS SYST-PATHOLOGY(*20506); PSYCHIATRY-PSYCHPATH-DYNM.THERAP(21002); TOXICOL -ENVIRONMNTL.INDUSTR(*22506); ENVIRON HEALTH-OCCURATNL HEALTH(*37013); ENVI RON HEALTH-A IR.WATR,SL POLLN(37015) Blosystemat1c Codes: HOMINIDAE(862 15 ) 19009060 A CASE OF STRANGULATION OF THE PENIS MIYAMOTO S-I; TAMIYA T; TAKATSUKA K OEP. UROL., SUNAGAWA. HOKKAIDO. JPN. NISHINIHON d UROL Coden: NHvJUA 41 (6). 1979 (RECD. 1900). 1129-1130. Language: JAPANESE Descriptors: NOTE HUMAN PROSTATE HYPERTROPHY URINARY DRIBBLING SWELLING VINYL CHLORIDE PIPE Concept Codes: BIOCHEM STUD-GENERAL(1006Q); PATHOLOGY-INFLA- MMATN,INFLAM DIS(12S08); URIN SYST/EXT SECR-PHYSL.BIOCHEM( I 5- 504); REPRODUCT SYST-GENL STUDS.METHS( 1650 I ); REPRODUCT SYST-PATHOLOGY(16506) B losystemat1c Codes: HOMINIDAE(06215) 19006004 LOSS OF VITAMIN A FROM TOTAL PARENTERAL NUTRITION SOLUTIONS MCKENNA' M C; BIER I J G NATL. INST. HEALTH, BUILD. 10. ROOM 5N-102. BETHESOA, MD. 20205. USA. 64TH ANNUAL MEETING OF THE FED. AM. SOC. EXP. BIOL., ANAHEIM, CALIF,. USA, APR. 13-10, 1900- FED PROC 39 (3). 1900. ABSTRACT 1561. Coden: FEPRA Language: ENGLISH DescrIptors; ABSTRACT HUMAN RETINOL POLY VINYL CHLORIDE INFUSION TUBING Concept Codes: GENL B IOL - S YMPOS I A . PROCDNC.S . RE VW( 00520) ; BIOCHEM STUD-GENERAL('IOOGO); BIOCHEM STUD-VII AMI NS( 10063): BIOCHEM STUD-LIPIDS( 10066); PATHOLOGY-THERAPY( 1 25 1 2 ) : NUTRITI- ON-MALNUTRITION,OBESITY(*13203); NUTRITION-VITAMINS.FAT-SOLUBLEf * 13 208) ; NUTRITION-PROPHYLAC,THERAP DIETS(* 132 18) B losystemat 1c Codes: FIOMINI DAE ( 862 I S ) 19005720 INTERNATIONAL AGENCY FOR RESEARCH ON CANCER MONOGRAPHS ON THE EVALUATION OF THE CARCINOGENIC RISK OF CHEMICALS TO HUMANS VOL. 19. SOME MONOMERS PLASTICS AND SYNTHETIC ELASTOMERS AND ACROLEIN LYONS FRANCE FEB. 7-13 1970 INT AGENCY RES CANCER LYONS. FR. INFERNATIONAL AGENCY FOR RESEARCH ON CANCER. 1ARC (INTERNATIONAL AGENCY FOR. RESEARCH ON CANCER) MONOGRAPHS ON THE EVALUATION OF THE CARCINOGENIC RISK OF CHEMICALS TO HUMANS. VOL. 19. SOME MONOMERS. PLASTICS AND SYNTHETIC ELASTOMERS, AND ACROLEIN. LYONS. FRANCE. FEB. 7-13. 1970. S13P. WHO: GENEVA. SWITZERLAND. ILLUS. PAPER. ISBN 92-032-1219-3. 0 (0). 1979. 5I3P. Language; ENGLISH Coden: IARMB Descriptors: BOOK ACRYLIC-ACID ACRYLATES ACRYLONITRILE CAPROLACTAM NYLON 6 CHLOROPRENE POLY CHLOROPRENE ETHYLENE POLY ETHYLENE METHYL METHACRYLATE POLY METHYL METHACRYLATE PROPYLENE POLY PROPYLENE STYRENE STYRENE OXIDE TETRA FLUORO ETHYLENE POLY TETRA FLUORO ETHYLENE DI ISO CYANATES POLY URETHANES VINYL ACETATE VINYL BROMIDE VINYL CHLORIDE VINYLI DENE CHLORIDE N PYRROL I DONE ACROLEIN VINYL-2 PYRROL I DONE POLY VINYL Concept Codes: BIOCHEM STUD-GENERAL(10060): BIOPHYS-MOLECUL PROP,MACROMOLEC( 10506); TOXICOL-GENL/EXP STUDS.METHS(* 22501); NEOPLSMS/NEOPL AGNT S-CARCI NOGENS(*24007) BlosystematIc Codes: HOMINIDAE(86215) 19005668 HEPATIC ANGIO SARCOMA ASSOCIATED WITH USE OF ANDROGENIC ANABOLIC STEROIDS FALK H: THOMAS L B; POPPER H: ISHAK K CENT. DIS. CONTROL, ATLANTA. GA., USA. 30TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASE. CHICAGO. ILL.. USA. NOV. 7. 1979. GASTROENTEROLOGY 77 (5). 1979. All. Coden: GASTA Language: ENGLISH Descriptors: ABSTRACT HUMAN VINYL CHLORIDE ARSENIC THOROTRAST CARCINOGEN Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS.REVW(00520 ) : BIOCHEM STUO-GENERAL(10060): BIOCHEM STUO-STEROLS.STEROIDS(IQ- 067 ) ; MINERALS( 100G9): DIGESTIVE SYST-PATHOLOGY( 14006 ) ; ENDOCRINE SYST-GONADS.PLACENTA( 17006); PHARMACOL-DRUG METAB.M- EIAB S TI MU(22003); PHARMACOL-ENDOCRINE SYST( 22016): TOXICOL-GENL/EXP STUDS.METHS(22501): TOXICOL -PIIARMACOLOGICAL(22504): NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(*24007 ) B losystemat1c Codes: HOMINIDAE(86215) DIALOG F11e5: BIOSIS Preview R&S 138465 402(See F I le55) (c. BIOSIS 1902) (Item 379 of 858) User 3614 25jan83 2 111 19003257 STUDY OF FUNGAL RESISTANCE OF SOME LIQUID PLASTICIZERS USED IN POLY VINYL CHLORIDE FORMULAS LINOVITSKAYA V M; KURGANOVA L N; ANISIMOV A A; BOCHKAREVA G G: OVCHINNIKOV YU A; KOMOLOVA V M GORKI STATE UNIV., GORKI, USSR, APPL BIOCHEM MICROBIOL (ENGL TRANSL PRIKL BIOKHIM MIKROBIOL) 15 (1). 1979. 54-57. Coden: APBMA Language: ENGLISH Descriptors: PENI ClLLIUM-FUNICULOSUM Concept Codes; BIOCHEM STUD-GENERAL(100G0): METABOLISM-GENL STUD,METAB PATHWf+ 13002): MICROBIOLOG APPARAT,METIIS.MED I A(020- 00); FOOD/INDUS MICRO-BIODEGRAD,DE T E R(* 3 9005): PHYSIOL-METAE0L1SM(*51519) PLANT Blosysteraat1c Codes: DEUTEROMYCETES(15500) 18061977 MORPHOLOGIC PARAMETERS OF HEPATIC INJURIES POPPER H SCH. MED.. CITY UNIV. N.Y., 535 E. SOTH ST.. NEW YORK. N.Y. 10021, USA. HUNTER. W. J. AND J. G. P. M. SMEETS (ED.). THE EVALUATION OF TOXICOLOGICAL DATA FOR THE PROTECTION OF PUBLIC HEALTH; PROCEEDINGS OF THE INTERNATIONAL COLOOUIUM. LUXEMBOURG. LUXEMBOURG. DEC. 7-8. 1976. 427P. PERGAMON PRESS: NEW YORK. N.Y., USA; OXFORD, ENGLAND. ILLUS. PAPER. ISBN 0-08-021998-5. 0 (0). 1979. P151 - 160. Coden: 07421 Language: ENGLISH Descriptors: REVIEW HUMAN RODENT EXPERIMENTAL ANIMAL SEX STEROIDS DRUGS VINYL CHLORIDE NECROSIS ANGIO SARCOMA FAT INFILTRATION CARCINOGENESIS MICROSCOPY BIOPSY ENVIRONMENTAL AGENTS MICROSOME Concept Codes: GENI. BIOL-SYMPOSI A.PROCDNGS.REVW(00520): MICROSCOPY-HISTOL.HISTOCHEM TECH(01056); ELECTRON MICROSCOPYt- 01058); CYTQLOGY/CYTOCHEM-ANIMAL(02506); CYTOLOGY/CYTOCHEM-HU- MAN(02508); BIOCHEM STUD-GENERAL( 10060); BIOCHEM STUD-LIPIDS(- 10066); BIOCHEM STUD - STEROLS.STEROIDS(10067); ANATOMY/HISTQL-- MICR0,ULTRAMICR5C(*11108); PATHOLOGY-DIAGNOSTIC( 12504 ) ; PATHO LOGY-NECROS I S ( 1 25 10} ; METABOLISM-GENL STUD,METAB PATHW( 13002): MTABOLISM-LIPIDS(13006); METABOLISM-STEROLS,STEROIDS(13008): DIGESTIVE 5YST-C.ENL STUDS . ME THS ( 1400 1 ) ; DIGESTIVE SYST-PATHOL- OGY(+14006): CARDIOVASC SYST-BLD VESS PATHOL(*14508): ENDOCRINE SY ST - GONADS,PLACENTA( 17006): BONE.JNTS.FASC.CONN/AD- IP-PATHOU 18006); PHARMACOL-DRUG METAB.ME TAR ST I MU(22003): PHARMACOL-ENDOCRINE SYST(22016); PHARMACOL-REPROOUCT SYST.IMP- LANT(22028); T0X1C0L-GENL/EXP STUDS,METHS(*2250 I ) : TOXICOL-PH ARMACOLOGIC AL ( *2 2504 ); TOXICOL-ENVIRONMNTL. INDUSTRf >22506) : NEOPLSMS/NEOPL AGNTS-PATH.CL INIC(24004): NEOPLSMS/NEOPL AGNTS-CARCINOGENS(+24007); ENVIRON HEALTH-A IR.WATR,SL P0LLN(3- 7015) Blosystemat 1c Codes: ANIMAL IA-UNSPECIFIED(33000): HOMINIDAE- (86215); CAVIIDA(86300) THE MIGRATION OF PLASTICIZERS FROM POLY VINYL CHLORIDE HEMO DIALYSIS TUBES GERSTOTT J: CHRISTIANSEN E; NIELSEN I L; NIELSEN B DEP. NEPHROL.. COPENH. CITY HOSP.. HVIDOVRE. DEN. PROCEEDINGS OF THE EUROPEAN DIALYSIS AND TRANSPLANT ASSOCIATION. AMSTERDAM. NETHERLANDS. JUNE 17-20. 1979. KIDNEY INT 16 (2). 1979. 222. Coden: KDYIA Language: ENGLISH Descriptors; ABSTRACT HUMAN PLASMA DI-2 ETHYLHEXYL PHTHALATE STERILIZATION GAS CHROMATOGRAPHY IRRADIATION Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS.REVW(00520 ) : RADIATION BIOL-RAOTN.ISOTOP TECH(06504); BIOCHEM STUD-GENERAL- (IOOGO); BIOPHYS-GENERAL BIOPHYS TECH( 10504 ); MOVEMENT( 12100) : PATHOLOGY-TMERAPY( 125 12) ; METABOLISM-GENL STUD.METAB PATHW(13- 002): CARDIOVASC SYST -GENL STUDS.METHS( 1450 1 ) : BLOOD/BODY FLDS-GENL STUDS.METHS( 15001); BLOOD/BODY FLDS-BLOOD.LYMPH STUD(15002); TOXI COL-GENL/EXP STUDS,METHS(* 2250 1 ): DISINFECT ION . D I S INF EC T ANTS .STERL(39500) BlosystematIc Codes; HOMINIDAE(862t5) 180G 1043 NECROTIZING CUTANEOUS VASCULITIS CAUSED BY POLY VINYL CHLORIDE PLASTIC TUBING BOMMER J; RITZ E DEP. INTERN. MED.. HEIDELBERG. W. GER. PROCEEDINGS OF THE EUROPEAN DIALYSIS AND TRANSPLANT ASSOCIATION. AMSTERDAM. NETHERLANDS. JUNE 17-20. 1979. KIDNEY INT 16 (2). 1979. 218. Coden: KDYIA Language: ENGLISH Descriptors: ABSTRACT HUMAN ALLERGY ATOPY HISTOLOGY IMMUNO HISTOLOGY DIALYSIS Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS.REVW(00520); MICROSCOPY-I II STOL .III STOCHEM TECH(0105G ) : C YT OLOGY/C Y TOCHE M - HU- MAN(02500); BIOCHEM STUD-GENERAL(10060): BIOPHYS-GENERAL BIOPHYS TECH( 10504); ANATOMY/HISTOL-MICRO.ULTRAM ICRSC( 11108); MOVEMENT( 12100); PATHOLOGY - INFLAMMATN.INFLAM 015(12508); PATHOLOGY-NECROSIS( 12510); PATHOLOGY - THERAPY( 12512); METABOLI SM-GENL STUD.METAB PATHW( 13002): CARDIOVASC SY S T-GENL STUOS.MF.THS( 14501 ) ; CARDIOVASC SYST-BLD VESS PATHOL (* 1 4S0B ) ; BLOOD/BODY FLDS-GENL STUDS.METHS( 1 5001): I NT EGUMFNT S Y S T-GENL STUDS.METHSf 18501): INTEGUMENT SYST-PATHOLOGY 1 * 18506 ) : TQXICOL-CENL/EXP STUDS.METHS(*22501 ); IMMUNOL/IMMUNOCHE M- GEN METH(34 502); 1MMUNOL/1MMUNOCHEM-IMMUNOPATFIOL(*34 500); ALLERGY - (*35500) BIosystemat1c Codes: HDMINIDAE(862 15 ) 1 imp Inn DIALOG F11e5: RIOSIS Previews 77-83/Ja R&S 138466 I D55 ) (c. BIOSIS 1982) (Item 383 of 858) User 3614 25Jnn83 2 112 10061750 EPIDEMIOLOGIC CONSIDERATIONS IN THE DESIGN OT TOXICOLOGIC STUDIES AN APPROACH TO RISK ASSESSMENT IN HUMANS WOODS J S BATTELLE HUM. AFFAIRS RES. CENT.. 4000 N.E. SEATTLE. WASH. 98105. USA. 41ST ST.. SYMPOSIUM ON THE ROLE OF EPIDEMIOLOGY IN TOXICOLOGY AT THE ANNUAL MEETING OF THE AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS AND THE SOCIETY OF TOXICOLOGY. HOUSTON. TEX.. USA, AUG. 15. 1978. FED PROC 38 (5). 1979. 1891-1896. Corien: FEPRA Language: ENGLISH Descriptors: ANIMAL MODEL VINYL CHLORIDE CARCINOGENESIS BIO STATISTICAL PROCEDURE DOSE RESPONSE RELATIONSHIP ENVIRONMENTAL AGENTS Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS.REVW(00520); MATHEMATIC BIOL/STATISTIC METH(O4500); BIOCHEM STUD-GENERAL( I - 0060); BIOPHYS-BIOCYBERNETICS( 105 1 5); PATHOLOGY-COMPARATIVE( 1- 2503): METABOLISM-GENL STUD.METAB PATHW( 13002); PHARMACOL-DRUG METAB , MET AB ST I MU ( 22003 ) : TOXICOL-GENL/EXP ST UDS . ME TI-1S ( * 2 250 I ) ; TOXI COL -ENVIRONMNTL.INDUSTR(* 22506); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(* 24007); PUB HEALTH-LAB METHS(*37006); PUB HEALTH-ADM INISTR.STATI ST ICS(37010); ENVIRON HEALTH-AIR.WATR.SL POLLN(37015); EPI DEMIOL-MISCELL STUD IES(3705G) Btosysteranttc Codes: ANIMAL!A-UNSPEClFI EDI 33000): 1I0MIN1DAE- (862 15) 18057879 CANCER AND INDUSTRIAL CHEMICAL PRODUCTION DAVIS D L; MAGEE B H TOXIC SUBST. PROGRAM. ENVIRON. LAW INST.. WASHINGTON. D.C. 20036, USA. SCIENCE (WASH D C) 206 (4425). 1979 (RECD. 1980). 1356, 1358. Coden: SCIEA Language: ENGLISH Descriptors: NOTE HUMAN BENZENE PER CHLOR ETHYLENE VINYL CHLORIDE ACRYLONITRILE ASBESTOS CHROMITE CHLOROFORM CARBON TETRA CHLORIDE TRI CHLOROETHYLENE CARCINOGEN LUNG CANCER SMOKING Concept Codes: BEHAVIOR BIOL-HUMAN BEHAVI OR(07004); BIOCHEM STUD-GENERAL(10060); MINERALS(10069); RESPIRATORY SYST-PATHOL- OGY(*16006); PSYCHI ATRY-ADDICTION(INC SMOKNG)(21004); TOXI COL - -GENL/EXP STUDS.METHS(22S01): TOXICOL-ENVIRONMNTL.INDUSTR(22- BOG ) ; NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(24007): ENVIRON HEAl.TII-OCCUPATNL HEALTIK *37013) ; PLANT PHYSIOL-CHEM CONSIUUENTS(5 1522); AGRONOMY-TOBACCO CR0PS{52512) Dlosyr. temnt Ic Codes: PLANT AE-UNSPEC I T I ED ( 11000 ) ; IIOMINI OA E ( - 002 15 ) UNITE RECH. PHYSI OPATHOL. HE PA TI DUE. INST. NATL. SAN I E RCCH. MED. UNITE 24. HOP. BEAUUON. 92118 CLICHY, FR. BIOCHEM PHARMACOL Coden: BCPCA 20 (24). 1979 (RECD. 1980). 3G67-366Q. Language: ENGLISH Descriptors: NOTE RAT BLOOD KIDNEY SPLEEN MUSCLE SKF-525-A PROADIFEN HYDRO CHLORIDE PHENO BARBITAL DDT METABOLIC-DRUG EPOXIDE HYDRASE CARCINOGENESIS INTRA PERITONEAL DOSE MICROSOMC Concept Codes: CYTOLOGY/CYTOCHEM-AN IMAL(02506); COMPARATIVE B IOCHEM-GENL STUDIES( 10010): BIOCHEM STUD-GENERAL( 10060); BIOCHEM 5TUD-NUCL ACD.PURNS.PYRM(10062); BIOCHEM STUD-PROTEIN- S. PEPTIDES.AMINO ACD( 10064): BIOPHYS-MOLECUL PROP,MACROMOLEC(- *10506); BIOPHYS-MEMBRANE PHENOMENA( 10508); ENZYMES-PHYSIOLOG- ICAL STUDIES( 10808): CHORDATE BODY REGNS-ABDOMEN( 113 1 4 ) ; PHYSIOLOGY-COMPARATIVE(12003); METABOLISM-GENL STUD,METAB PATHW( 13002); METABOLISM-NUCL ACD.PUR I NS.PYRIM( 13014); DIGESTIVE SYST-PATHOLOGY(* 14006); BLOOD/BODY FLDS-GENL STUDS,METMS(15001); BLOOD/BODY FLOS-BLOOD.LYMPH STUD(15002): LOOO/BODY T LDS-LYMPt IA T TISS.RES(* 15000); URIN SYST/EXT SECR-GEN STUD.METH( 15501); URIN SYST/EXT SECR-PATHOLOGY( 1 550- 6); MUSCLE SYST-GENL STUDS.METHS(17501); MUSCLE 5YST-PATH0L0GY( 17506); PHARMACOL-GENERAL STUDIES(22002) : PHARMACOL-DRUG METAB.METAB ST I MU(* 22003); ROUTES OT IMMUNI Z INFECT . THERAP (22 100) : TOXICOL-GENL/EXP STUDS . ME T HS ( 2 - 2501): TOXI COL -ENVIRONMNTL.INDUSTR(22506); NEOPLSMS/NEOPL AGNT S-CARC1N0GEN5(*24007); ENVI RON HEALTH-A IR.WATR.SL P0LLN(3- 7015); PEST CONTRL GENL/PESTICS/HERBICS(54600); ECONOM ENTOMOL-CHEM PHYS CONTRL(60016) Blosystemat1c Codes; MUR I DAE(86375); ABSTRACTS OF ENTOMOLOGY(96000) 10057819 EFFECTS OF INDUCERS ON THE IN-VIVO COVALENT BINDING OF A VINYL CHLORIDE METABOLITE TO LIVER TRACTIONS PESSAYRE 0; WANDSCIIFER U C; DESCAIOIRE V; DOLDFR A; RENHAMOU DIALOG F11e5: BIOSI5 Previews 77-83/Jan BA7502 R&S 138467 BJOSIS 1982) (Item 306 of 858) User 3614 25Jan83 2 113 1 80505*1 <1 DENITRIFICATION AND REMOVAL OF HEAVY METALS FROM HASTE WATER BY IMMOBILIZED MICROORGANISMS HOLLO J; TOTH J; TENGERDY R P; JOHNSON J E VENKATSUBRAMANIAN, K. (ED.). ACS (AMERICAN CHEMICAL SOCIETY) SYMPOSIUM SERIES. VOL. 106. IMMOBILIZED MICROBIAL CELLS; SYMPOSIUM AT THE 176TH MEETING. MIAMI BEACH, FLA., USA. SEPT. 14, 1978. X+257P. AMERICAN CHEMICAL SOCIETY: WASHINGTON, D.C., USA. ILLUS. Coden; ACSMC ISBN 0-8412-0508-6. O (O). 1979. P73-86. Language: ENGLISH Descriptors: REVIEW PSEUDOMONAS-AERUG1NOSA POLY VINYL CHLORIDE FILM MELT BLOWN POLY PROPYLENE WEB Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS.REVW(00520): EC0LOGY-LIMNOLOGY(*O7514): ECOLOGY-WATR RESRCH.FISHERY BIOL(07 5 17); BIOCHEM METH-GENERAL(* 10050 ) : BIOCHEM METH-MINERALS(* 10059); BIOCHEM STUD-GENERAL( 10060); MINERALS(- 10069); BIOPHYS-GENERAL BIOPHYS TECH(10504); BIOPHYS-BIOENGIN- EERING(*10511); METABOLISM-GENL STUD,METAB PATHW(13002); MINERALS(* 13010); TOXI COL-ENVIRONMNTL.INDUSTR(22506) ; BACTERI- A-PHYSIOLOGY.BIOCHEMISTRY(*31000); MICROBIOLOG APPARAT,METHS.- MED I A(32000); ENVIRON HEALTH-SFWG DISP,SANITAR(* 37014); ENVIRON HEALTH-AIR.WATR.SL POLLN(* 370 15); FOOD/INOUS MICRO-GENL.MISC STUDS(*39008) BlosystematIc Codes: P5EUDOMONADACEAE(04716) 18047256 ENVIRONMENTAL LIVER TUMORS POPPER H; THOMAS L B KURUME MED d 26 (3). 1979 (RECD. 1980). 1B9-204. Coden: KRMJA Language: ENGLISH Descriptors: REVIEW HUMAN RODENT CARCINOGENESIS STEROIDS VINYL CHLORIDE ANGIO SARCOMA CARCINOMA HEPATITIS B INFLAMMATION HYPERTENSION INDUSTRIAL TOXIJVS Concept Codes: BIOCHEM STUO-GENERAL( 10060): BIOCHEM STUD-STEROLS.STEROIDS(10067); PATHOLOGY-I NFLAMMATN,I NFLAM DIS- (12508); DIGESTIVE SYST-PATHOLOGY( 1 4006): CARDIOVASC SYST-BLO VESS PATHOLf* 14508); TOXI COL-ENVIRONMNTL.INDUSTR(* 22506); NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007); VIROLOGY-ANlMAL HOST V I RUSE S(33506); MED/CL IN MICROBIOL-VIROLOGY(36006); ENVIRON HEALTH-OCCUPATNL HEALTH(*37013); ENVIRON HEALTH-AIR.WATR.SL POLLN(*37015) Blosystemat1c Codes: ANIMAL VIRUSES-UNSPECIFIED(02 200): IIOMINIDAE(86215): RODENT IA-UNSPECIFI ED(86265) CARCINOGENS: SELECTED METHOOS DF ANALYSIS. VOL. 2. METHODS TOR THE MEASUREMENTS OF VINYL CHLORIDE IN POLY (VINYL CHLORIDE). AIR. WATER AND FOODSTUFFS. XIII+142P. INTERNATIONAL AGENCY FOR RESEARCH ON CANCER: LYON, FRANCE. ILLUS. ISBN 92-832-1122-7. 0 (O). 1979. XIII+142P. Coden: IARCC Language: ENGLISH Descriptors: BOOK F1UMAN ANIMAL WORKER EXPOSURE Concept Codes: SOCIAL BIOL/HUMAN ECOLOGY(05500) ; ECOLOGY-ANIMAL(07508); BIOCHEM METH-GENERAL(10050): BIOCHEM STUD-GENCRAL(10060): BIOPHYS-GENERAL BIOPHYS TECH(10504); FOOD TECH-GENL STUDS,METHS(13502): TOOD TECHEVALNS PHYS.CIIEM PROPS( 13530); TOX I COL-F000,RESIDS.AODIT.PRESRV( 22502 ) ; TOXIC-I OL - E NVIRONMNTL,INDUSTR(*22506); NEOPLSMS/NEOPL AGNTS-CARC I NOG - ENS(*24007); ENVIRON HEALTH-OCCUPATNL HEALTH(37013): ENVIRON HEALTH-AIR.WATR.SL POLLN(37015) BlosystematIc Codes: ANlMALI A-UNSPECIFI ED(33000); M0MIN1DAE- (862 15) 18045465 OVERVIEW OF POTENTIAL MUTAGENIC PROBLEMS POSED BY SOME PESTICIDES AND THEIR TRACE IMPURITIES FISHQEIN L WORKSHOP ON HIGHER PLANT SYSTEMS AS MONITORS OF ENVIRONMENTAL MUTAGENS, MAR INELAND, FLA., USA. JAN. 15-19, 1978. ENVIRON HEALTH PERSPECT 27 (0). 1978 (RECD. 1979). 125-132. Coden: EVHPA Language: ENGLISH Descriptors: REVIEW HUMAN ORGANISM DDT HEXA CHLORO BENZENE 2 4 5-T PENTA CHLORO PHENOL CARBAMATE VINYLIOENE CHLORIDE TRIAZINE VINYL CHLORIDE DI CHLORO PROPENE TRICHLORPHON HERBICIDE CARCINOGEN Concept Codes: CYTOLOGY/CYTOCHEM-HUMAN(02508 ) ; GENETICS/CYT - OGENET-GENL STUDIES!*03502); GENETICS/CYTOGENET-HUMAN(*03508) ; BIOCHEM STUD-GENF.RAL( 10060) ; BIOCHEM STUD-NUCL ACD , PURNS . P YRM- (10062); BIOPHYS-MOLECUL PROP,MACROMOLEC(10506); METABOLISM-N- UCL ACD.PURINS.PYRIM(13014): TOXI COL-GENL/EXP STUDS.METHS(* 2 - 2501): TOXICOL-ENVIRONMNTL.INDUSTR(* 22506); NEOPLSMS/NEOPL AGNT S-CARCINOGEN$(* 24007); ENVI RON HEALTH-A IR.WATR,SL POLLN(*- 37015); PEST CONTRL GENL/PEST 1CS/HERB1CS(54600): ENTOMDL-CHEM PHYS CONTRL(60016) ECONOM B losystematIc Codes: DRGANI5MS-UNSPECIFlED(00500); HOMJNIDAE(862 15); ABSTRACTS OF ENTOMOLOGY(96000) 180472 13 international agency for research on cancer science PUBLICATIONS NO. 22. ENVIRONMENTAL CARCINOGENS SELECTED METHODS OF ANALYSIS VOL. 2. METHODS FOR THE MEASUREMENTS OF VINYL CHLORIDE IN POLY VINYL CHLORIDE AIR WATER AND FOODSTUFFS EGAN It EGAN. H. (ED.). IARC (INTERNATIONAL AGENCY TOR RESEARCH .ON DIALOG F11e5: BIOS1S Previews 77-83/Jan BA7502 : RRM2402 ( Se< R&S 138468 '82) (Item 390 of 858) User 36U 25J.m83 2 114 18045384 LACK OF MUTAGENIC EFFECT OF VINYL CHLORIDE MONOMER IN THE MAMMALIAN SPOT TEST PETER S; UNGVARY G MUTAT RES 77 (2). 1980. Language: ENGLISH 193-196. Coden: MUREA Descriptors: NOTE MOUSE C-57BL-6JHAN STRAIN HUMAN CYCLO PHOSPHAMIDE COAT COLOR OCCUPATIONAL EXPOSURE Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(*02506); GENETICS/C- YTOGENET-ANIMAL(*03506); GENETICS/CYTQGENET-HUMAN(*03508); MATHEMATIC BIOL/STATISTIC METH(04500); BIOCHEM STUD-GENERAL( 1 - 0060); BIOCHEM STUO-NUCL ACO.PURNS.PYRM( (0062); METABOL1SM-NU- CL ACD.PURINS.PYRIM(* 13014); REPRODUCT SYST-GENL STUDS.METHS(- 16501); INTEGUMENT SYST-GENL STUDS.METHS( 1850 1 ); INTEGUMENT SYST-PHYSIOL.BIOCHEM( 18504); INTEGUMENT SYST-PATHOLOGY(* 18506) PHARMACOL-GENERAL STUD1E S(22002); ROUTES OF IMMUNIz.INFECT.THERAP(22100): TOXICOL -ENVIRONMNT L.INDUSTR(*22506); NEOPLSMS/NEOPL AGNTS-THE- RAP.AGNT(24008); ENVIRON HEALTH-OCCUPATNL HEALTH(* 37013); CHEMOTHERAPY-GEN STUD.METH.METAB(30502) Blosystemat1c Codes: MAMMAL IA-UNSPECIFI ED AND EXTINCT(85700) : H0MINIDAEI86215) ; MURIDAE(86375) 1B0453B 1 MUTAGENICITY OF VINYL CHLORIDE IN THE AMES TEST POSSIBLE ARTIFACTS RELATED TO EXPERIMENTAL CONDITIONS DE MEESTER C; DUVERGER-VAN BOGAERT M; LAMBOTTE-VANDEPAER M; ROBERFROID M; PONCELET F; MERCIER M MUTAT RES 77 (2). 1980. 175-180. Coden: MUREA Language: ENGLISH Descriptors: NOTE SALMONELLA-TYPHIMURIUM STRAIN TA-1530 RAT LIVER MICROSOME HUMAN Concept Codes: CYTOLOGY/CYTOCHEM-AN1MAL(*02506): GENETICS/C- YTOGENET-ANIMAL(*03506); GENET1C5/CYT0GENE T-HUMAN(*03508); BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-NUCL ACD.PURNS.PYRM- (10062); META80LISM-NUCL ACD,PUR I NSPYRIM(* 13014); TOXICOL-GE- NL/EXP STUDS,METHS(*22501): NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(- 24007); BACTERIAL AND VIRAL GENETICS(31500); MICROBIOLOG APPARAT.METHS.MEDIA(32000) Blosystemat1c Codes: ENTEROBACTERI ACEAE(040 10 ) ; HOMINIDAE(8" 6215); MURIDAE(86375) Descriptors: B AC I L LUS - CO AC.UL ANS GLUCOSE IS0MERA5E Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS,REVW(00520); BIOCHEM METH-CARBOHYORATES(* 10058); BIOCHEM STUD-GENERAL( 1006- O); BIOCHEM STUD-PROTEINS,PEPTIDES.AMINO ACO(I00G4); BIOCHEM STUO-CARBOHYDR.( 10068); MINERALS( 10069): BIOPHYS-GENERAL BIOPHYS TECH( 10504); BIOPHYS-BIOENGINEERING(* 105 1 1); ENZYMES-- ME THODS(* 10804); METABOLISM-CARBOHYDRATES( 13004); BACTERIA-PH YSIOLOGY .BIOCHEMISTRY(*31000); MICROBIOLOG APPARAT.ME THS.MED I - A02000); FOOD/INDUS MI CRO - S YN. B 10 A S S . F E RM ( * 39007 ) B iosystemat 1C Codes: BACILLACEAE(05610) 18042394 INFLUENCE OF SERUM PROTEINS ON THROMBOSIS AND LEUKOCYTE ADHERENCE ON POLYMER SURFACES BARBER T A; LAMBRECHT L K; MOSHER D L; COOPER S L SCANNING ELECTRON MICROSCOPY MEETING. WASHINGTON. D.C.. USA, APR. 16-20. 1979. SCANNING ELECTRON M1CR0SC 1979 (3). 1979. 881-890. Coden: SEMYB Language: ENGLISH Descriptors: DOG PLATELET MONOCYTE POLYMORPHONUCLEAR NEUTROPHIL MIGRATION CHEMO TAXIS AGGREGATION FIBRIN GAMMA GLOBULIN ALBUMIN 1MMUNO GLOBULIN G VON WILLEBRAND FACTOR ALPHA-2 MACRO GLOBULIN FJBRONECTIN ANTI FIBRONECTIN .SILICONE RUBBER POLY VINYL CHLORIDE TRANSMISSION ELECTRON MICROSCOPY SCANNING ELECTRON MICROSCOPY Concept Codes: GENL BIOL-SYMPOSIA.PROCDNGS.REVW(00520); MICROSCOPY-CYTOLOG,CYTOCHEM TECH(O1054); ELECTRON MICR05C0PY(- *01O5B); CYTOLOGY/CYTOCHEM-ANIMAL(02506); BIOCHEM STUD-GENERA- L(10060); BIOCHEM STUD-PROTEI NS,PEPTIDES.AM I NO ACD(*10064); BIOCHEM STUD-CARBOHYDR.(10068); ANATOMY/HISTOL-MICRO.ULTRAMIC- RSC(* 1 I 108); MOVEMENT( 12100): CARDIOVASC SYST-RLD VESS PATHOLt * 14500); BLOOD/BODY FLDS-BLOOD.LYMPH STUD(* 15002) : BLOOD/BODY FLOS-BLOOD CELL STUDS(*15004); BLOOO/BOOY FLDS-BLD.LYM.RES PATH(15006): BLOOD/BODY F LDS-LYMPHAT TISS.RES(* 15008): IMMUNOL/IMMUNOCHEM-GEN METH(34502): IMMUNOL- /1MMUNOCHEM- IMMUNOPATHOL(3450B) B losystemat1c Codes: CANtOAE(85765 ) 18045096 EVALUATION OF A NOVEL MICRO POROUS POLY VINYL CHLORIDE SILICA SUPPORT FOR IMMOBILIZED ENZYMES ITS USE IN A FLOW-THROUGH REACTOR SYSTEM FOR PRODUCTION OF FRUCTOSE GDI DBERG B 'S; IIAUS5ER A G; GILMAN K R; CHEN R Y VENKATSUBRAMANIAN. K. (ED.). AC5 (AMERICAN CHEMICAL SOCIETY) SYMPOSIUM SERIES. VOL. 106. IMMOBILIZED MICROBIAL CELLS: SYMPOSIUM AT THE 176TH MEETING. MIAMI BEACH. FLA.. USA. SEPT. 14. 1978. X+257P. AMERICAN CHEMICAL SOCIETY: WASHINGTON, D.C.. USA. ILl.US. ISBN 0-8412-0508-6. O (0). 1979. PI73-I86. Coden: ACSMC Lannunnn: FNGI ISM R&S 138469 DIALOG FHe5: BIOSIS Preview^ 77-B3/dan BA7502:RRM2402(See F I 1e55) (c. BlOSlb 15u., ,/tem 394 of 858) User 3614 25Jan83 2115 18041743 NECROTIZING DERMATITIS RESULTING FROM MEMO DIALYSIS WITH POLY VINYL CHLORIDE TUBING BOMMER d: RITZ E; ANDRASSY K ANN INTERN MED Coden: AI MEA 91 (6). 1979 (RECO. 1900). 869-870. Language: ENGLISH Descriptors: NOTE HUMAN SERUM HEPATITIS B SURFACE ANTIGEN EOS INOPHILI A ALLERGY HISTOLOGY PARATHYROID HORMONE Concept Codes: MICROSCOPY-HISTOL,HISTOCHEM TECH(0t05G); CYTOLOGY/CYTOCHEM-HUMAN(02508); BIOCHEM STUD-GENERAL(10060); BIOPHYS-GENERAL BIOPHYS TECH!10504): ANATOMY/ITISTQL-MICRO.ULT- RAMICRSC!11108); MOVEMENT( 12100): PATHOLOGY - INFLAMMATN. INFLAM DIS( 12508): PATHOLOGY-NECROSIS! 125 10) : METABOLISM-GENL 5TUD.METAB PATHW(13002); DIGESTIVE SYST-PATHOLOGY( 1 A006); BLOOD/BODY FLDS-GENL STUDS.METHS(15001); BLOOD/BODY FLDS-BLOOD.LYMPH STUD!15002); BLOOD/BODY FLDS-BLOOD CELL STUOSC * 1500A); BLOOD/BODY FLDS-BLO.LYM.RES PATH(* 15006): ENDOCRINE SYST - PARATHYROID(17010); INTEGUMENT SYST-GENL STUDS.METHS!18501 ); INTEGUMENT SYST-PATHOLOGY(18506): TOXICOL-GENL/EXP STUDS.METHS!*22501); IMMUNOL/1MMUNOCHEM- IMMU- NOPATHOL!+34508): ALLERGY!+35500); MED/CLIN MICROBIOL-VIROLOGY(36006) BlosystematIc Codes: ITOMI NI0AE(862 15) ANIMAL VIRUSES-UNSPECIFIED(02200); 18041238 DETERMINATION OF THE CONTENT OF DI-2 ETHYLMEXYL PHTHALATE IN BLOOD PREPARATIONS STORED IN POLY VINYL CHLORIDE BAGS PIK YU; BRA IER YU: KAL'MANNE ZH; I0ZHEFNE P INST. EXP. MEO.. ACAD. SCI. HUNG. PEOPLE'S REPUB., BUDAPEST. HUNG. PROBL GEMATOL PERELIV KROVI 24 (2). 1979. 49-51. Codon: PGPKA Language: RUSSIAN Descriptors: HUMAN BLOOD THROMBOCYTE MEDICOR M-1 BAG BIOPACK P BAG ETHER ACETONE N HEPTANE ACID CITRATE DEXTROSE SOLUTION LIPID SOLUBILITY SATURATION CURVE Concept Codes: CYTOLOGY/CYTOCHEM-HUMAN!02508): MATHEMATIC BIOL/STATISTIC METH(04500): CLIN BIOCIIEM-GENL SIUOlES( 10006); BIOCHEM STUD-GENERAL(10060): BIOCHEM STUD -LIPIDS( IOOG6); BIOCHEM STUD-CARBOHYDR.(10068); BIOPHYS-MOLECUL PROP.MACROMOL- EC!10506); BLOOD/BODY FLDS-GENL STUDS.METHS(*15001); BLOOD/BODY FLDS-BLOOD.LYMPH STUD!15002); BLOOD/BODY FLDS-BLOOD CELL STUDS!15004); TOXICOL-GENL/EXP STUDS.ME1NS(+22501) B losysternnt 1c Codes: HOMINIDAE ( 862 15 ) 1978. ENVIRON HEALTH PERSPECT 27 (0). 1978 (RCCD. 1979). 7-10. Coden: E VHPA Language: ENGLISH Descriptors: HUMAN VINYL CHLORIDE KEPONE INSECTICIDE POLY BROMINA TED 81 PHENYL Concept Codes: GENL BIOL-SYMPOSI A,PROCDNGS.REVW(005?0 ) : BIOCHEM STUD-GENERAL! 10060); TOXI COL-ENVIRONMNTL.I NOUSTR( 225 - 06); NE0PL5MS/NE0PL AGNTS-CARCI NOGENS(24007 ); ENVIRON HEALTH-AIR.WATR.SL POLLN(37015 ); EPI DEM IOL-ORGAN IC DIS.NEOPLA- SMS(* 37054 ): PEST CONTRL GENL/PEST ICS/HERBICS(54600): ECONOM ENTOMOL-CHEM PHYS CONTRL(60016) B losystemat Ic Codes: HOMINI DAE(862 1 5 ) : ABSTRACTS OF ENTOMOLOGY!96000) 18036785 METABOLIC ACTIVATION OF HALOGENATED ETHYLENES BOLT H M INST. TOZIKOL.. UNIV., WILHELMSTR. 56. 7400 TUEBINGEN. W. GER. REMMER, H. ET AL. (ED.). FALK SYMPOSIUM. NO. 25. PRIMARY LIVER TUMORS: PROCEEDINGS. TITISEE. WEST GERMANY. OCT. 3-5. 1977. XVI +51 IP. UNIVERSITY PARK PRESS: BALTIMORE, MD. . USA. ILLUS. ISBN 0-B391 - 1226-2. 0 (0). 1978 (RECD. 1979). P285-294. Coden: FASYD Language: ENGLISH Descriptors: REVIEW RAT LIVER MICROSOMES TR1 CHLORO ETHYLENE VINYLI DENE CHLORIDE VINYL CHLORIDE CARCINOGEN MUTAGEN EPOXIDE Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS.REVW(00520): GENETICS/CYTOGENET-ANIMAL!+03506); BIOCHEM STUD-GENERAL(10060) ; MINERALS! 10069); METABOLISM-GENL STUD,METAB PATIIW(13002 ) : MINERALS! + 13010): DIGESTIVE SYST-PHYSIOL.BlOCHfM( 14004 ) : TOXICOL-GENL/EXP STUDS,METHS(+22501); NEOPLSMS/NEOPL AGNTS-CA- RCINOGENS!`24007) BlosystematIc Codes: MUR 1 DAE(86375) 18040373 ENVIRONMENTAL POLLUTANTS AND THE EPIDEMIOLOGY HEATH C W JR CHRONIC DIS. DIV. , BUR. EPIDEMIOL.. CENT. ATLANTA, GA. 30333, USA. WORKSHOP ON HIGHER' PLANT SYSTEMS AS OF CANCER OIS. CONTROL. MONITORS OF DIALOG FHeS: BIOSIS Previews 77-83/Jan BA7502:RRM2402(See FlleS5 R&S 138470 :m 398 of 858) User 3614 25Jan83 2116 18036777 EFFECT OF LONG-TERM VINYL CHLORIDE EXPOSURE IN MOUSE LIVER STRUCTURE SCHAFFNER F MT. SINAI SCH. MED.. 1 E. 100TH ST., NEW YORK. N.Y. USA . 10029 REMMER. H. ET AL. (ED.). FALK SYMPOSIUM, NO. 25. PRIMARY LIVER TUMORS; PROCEEDINGS. T I TI SEE. WEST GERMANY. OCT. 3-5. 1977. XVI +5 1 IP, UNIVERSITY PARK PRESS:- BALTIMORE, MD., USA. ILLUS. ISBN 0-8391-1226-2. P 189-200. Coden; FASYO 0 (O). 1978 (RECD. 1979). Language: ENGLISH Descriptors: LIVER ANGIO SARCOMA SCREENING SINUSOIDAL CELL PROLIFERATION RETICULUM FIBERS COLLAGEN MACROPHAGES LYMPHOCYTES HEPATOCYTES ULTRASTRUCTURE HYPERTROPHY CHLORO ETHYLENE OXIDE CARCINOGEN Concept Codes: GENL BIOL-SYMPOSIA,PROLONGS,R EVW(00520): CYTOLOGY/CYTOCHEM-ANIMAL(02506); BIOCHEM STUD-GENERAL(10060): BIOCHEM STUD-PROTEINS,PEPTIDES.AMINO ACO(IOOGA); ANATOMY/HI ST - OL-MICRO,ULTRAMICRSC(11108);" PATHOLOGY-DIAGNOSTIC(12504); DIG ESTIVE SYST-PATHOLOGY{14006); BLOOD/BODY FLDS-BLOOD CELL STUDS(15004); BLOOO/BOOY FLOS-LYMPHAT TISS.RES(15008); BONE,JNTS,FASC.CONN/AD IP-PHY.8CH( 10004); TOXICOL -ENVIRONMNTL,INOUSTR(*22506); NEOPLSMS/NEOPL AGNTS-DIA- GNS METH(*24001); NEOPLSMS/NEOPL AGNTS-CARC1NOGENS(*24007): ENVIRON HEALTH-OCCUPATNL HEALTH(*37013) Blosystemat1c Codes: MURIDAE(86375) 18036607 GENETIC DAMAGE CARCINOGENESIS AND ENVIRONMENTAL MUTAGENS COULTER J R DEP. TISSUE PATHOL.. INST. MED. VET. SCI.. FROME RO. . ADELAIDE. S. AUST. 5000. AUST. AUST J PHARM SCI 8 (2). 1979. 33-39. Codon: AUP5B Language: ENGLISH Descriptors: HUMAN ANIMAL SMOKING VINYL CHLORIDE EPIDEMIOLOGY Concept Codes: GENET ICS/CYTOGENET-HUMAN(*03508); BEHAVIOR BIOL-HUMAN 0 EHA VI OR(07004); BIOCHEM STUO-GENERAL( 10060!: PSYCHIATRY-ADDICTION(INC SMOKNG)(21004); TOXI COL-GENL/EXP STUDS.METHS(* 22501): TOXI COL -ENVIRONMNTL.INDUSTR( *22506 ) ; NEO- PLSMS/NE0P1. AGNTS'CARCINOGENS(*24007); PUB HEALTH-AOMINISTR.S- TATISTICS(37010): ENVIRON HEALTH-OCCUPATNL HE ALTH(370 13 ) ; EP IOEMIOL-ORGANIC 01S.NEOPLASMS(*37054 ); PLANT PHYSIOL-CHEM CONST ITUENTS(51522) fllosystematlc Codes: PLANTAE-UNSPECIFI ED( 110OO): VERTEBRATA- -UNSPECIFIED(05150); HOMINIOAE(86215) 18036751 ENVIRONMENTAL CHEMICALS CAUSING CANCER ANO GENETIC.BIRTH DEFECTS MUTAGENICITY TESTING FOR REACTIVE METABOLITES AMES B N DEP. BIOCHEM.. UNIV. CALIF.. BERKELEY. CALIF. 94720, USA. COHEN. Y. (EO.). PROCEEDINGS OF THE INTERNATIONAL CONGRESS OF PHARMACOLOGY. NO. 7, ADVANCES IN PHARMACOLOGY AND THERAPEUTICS. VOL. 9. TOXICOLOGY. PARIS. TRANCE. L978. XI+304P, PERGAMON PRESS: NEW YORK, N.Y.. USA; OXTORD, ENGLAND. ILLUS. ISBN 0-08-023199-3. O (0). 1978 (RECD. 1979). P29-40. Codon: PCPMB Language: ENGLISH Descriptors: SALMONELLA HUMAN RAT SMOKING VINYL CHLORIDE NITRITE ETHYL DI BROMIDE CARCINOGEN ONA DAMAGE Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS.REVW(00520): GENET ICS/CYTOGENET-ANIMAL(*03506); GENETICS/CYTOGENET - HUMAN (03508 ) ; BEHAVIOR BIOl.-IIUMAN BEHAVIOR - (07004): BIOCHEM STUD-GENERAL(100G0); BIOCHEM STUO-NUCL ACD.PURNS", PYRM( 10062) : METABOLISM-NUCL ACD,PURINS,PYRIMf 1301- 4); PSYCHIATRY-ADDICTION(INC SMOKNG)(21004): I OX I COL-GENL/EXP S TUDS,ME T I IS(* 2 2501); TOX I COL -ENV1R0NMN1L.INDUSTR(*22506); NEO PLSMS/NEOPL 'AGNIS-CARCINOGENS(*24007); OE VE LOI'MN r L BIOL-PATHO- LOGICAL(*25503); OEVELOPMNTL BIOL-DESCRIP 1ERATOL(*25552); BACTERIAL ANO VIRAL GENE T I CS ( 3 1500 ) : MICROBIOLOC, APPARAT .METHS,MF.DIA( 32000) ; PLANT PI IY S I OL - Cl IE M CONSTITUENIS ( 5 - 1522) BlosysternatIc Codes; ENTEROBACTERI ACEAE(04 810): PLANTAE-UNSPECI r i F0( i tonn): nriM I nt nx f (nci i s i - unottiAUiniir.i DIALOG FUe5: BIOSIS Previews 77-83/Jan BA7502:RRM2402(See Flle55) R&S 138471 - .jm-c; iitem 401 of 85B) User 3G14 25Jan83 2 117 18036GB0 CELL TRANSFORMATION ASSAYS STYLES J A CENT. TOXICOL. LAB., IMP. CHEM. INO. LTD., ALDERLEY PARK. MACCLC SEI ELD . CHESHIRE. ENGL,. UK. PAGET. G. E. (ED. ). SUB-MAMMALIAN SYSTEMS: UNIVERSITY PARK PRESS: 0-8391- 1367-6. 0 (O). Language; ENGLISH TOPICS IN TOXICOLOGY; MUTAGENESIS IN STATUS AND SIGNIFICANCE. XIV+231P. BALTIMORE, MO.. USA. ILLUS. .ISBN 1979. P147-164. Coden: 07966 Descriptors; SALMONELLA BABY HAMSTER KIDNEY CELL AMES TEST HUMAN 4 AMINO BI PHENYL TOBACCO SMOKE CONDENSATE P NITROSQ DI METHYL ANILINE TRI CHLORO ETHYLENE VINYL CHLORIDE ETHYLENE DI CHLORIDE ANILINE NORHARMAN CHLOROFORM 0 TOLUIDINE 2 AMINO TRIAZOLE GUANAZOLE SACCHARIN PIIOSPHORAMIOE BUTTER YELLOW CYCLAMATE HEXA METHYL Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL('02506); CYTOLOGY/C- YT0CHEM-HUMAN(*02508); GENETICS/CYTOGENET-AN IMAL(*0350G); GEN ET ICS/CYTOGENET-HUMAN(*0350B); BEHAVIOR BIDL-HUMAN BEHAVIOR(0- 7004); BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-NUCL ACD.PURNS,PYRM(10062); ANATOMY/HISTOL-MICRO.ULTRAMICRSC(11108) ; METABOLISM-NUCL ACD.PUR INS.PYRIM(* 13014); FOOD TECH-PREP,PR- DCESSNG,STORAGE! 13532 ) ; URIN SYST/EXT SECR-GEN STUD.METH( 1550- 1); PSYCHIATRY-ADDICTIONCINC SMOKNG)(21004); TOXI COL-GENL/EXP STUDS.METHS(*22501); TOXI COL-FOOD.RESIDS.ADD IT.PRESRV(22 502); TOXICOL-ENVIRONMNTL,INDUSTR(2250G); NEOPLSMS/NEOPL AGNTS-CARC- INOGENS(*24007); PEDIATRICS(25000); BACTERIAL AND VIRAL GENETICS(31500): MICROBIOLOG APPARAT,METHS,MEDIA(32000); TISS CULTURE-APRARAT,METHS.MEDIA(32500); ENVIRON HEALTH-OCCUPATNL HEALTH(37013); ENVIRON HEALTH-AIR ,WATR.SL POLLN(37015); PLANT PHYSIOL-CHEM C0NSTITUENTS(51522); AGRONOMY-TOBACCO CR0PS(S2S1- 2) Blosysteniat1c Codes: ENTEROBACTERIACEAE(04810); SOLANACEAEt- 26775); HOMINIDAE(86215); CRICETIDAE(86310) 10030686 PULMONARY MANIFESTATIONS OF VINYL CHLORIDE AND POLY VINYL CHLORIDE EXPOSURES DEMETER S L: CORDASCO E M CLEVE. CLIN. FOUND.. CLEVELAND, OHIO, USA. 75T1I ANNUAL MEETING OF THE AMERICAN LUNG ASSOCIATION HELD IN CONJUNCTION WITH THE 74TH ANNUAL MEETING OF THE AMERICAN THORACIC SOCIETY AND THE 67TH ANNUAL MEETING OF THE CONGRESS OF LUNG ASSOCIATION STAFF. LAS VEGAS. NEV., USA. MAY 13-1G, 1979. AM REV RESPIR DIS 119 (4 PART 2). 1979. 210. Coden: ARDSB Language; ENGLISH Descriptors: ABSTRACT HUMAN OCCUPATIONAL LUNG DISEASE CHEST X-RAY Concept Codes: GENL BIOL-SYMPOSIA.PROCDNGS,REVW(00520); PHOTOGRAPHY-METHS.MATLS.APPARAT(OIO 12); SOCIAL BIOL/HUMAN ECOLOGY(05500); RADIATION BIOL-RADTN.ISOTOP TECH(06504); BIOCHEM STUD-GENERAL( 10060); ANATOMY/HISTOL-RAD IOLOGIC( 11106); CHORDATE BODY REGNS"THORAX( 113 12); PATHOLOGY-DIAGNOSTIC( 12504) ; RESPIRATORY SYST-GENL STUD.METHS( 16001): RESPIRATORY TOXICOL-ENVIRONMNTL.INDUSTR(*2 2506); ENVIRON HEAL Til-OCCUPATNL HEALTH(*37013); ENV1 RON HEALTH-A 1R.WATR.SL PDLLN( 370 1 5) B losystemat 1c Codes; F10MINI DAE (862 15 ) 18029832 2 BUTANONE AND TETRA HYDRO FURAN CONTAMINATION IN THE WATER SUPPLY WANG T C; BRICKER J L HARBOR BRANCH FOUND. INC.. RR1. BOX 196. FT. PIERCE. FLA. 33450. USA. BULL ENVIRON CONTAM TOXICOL Coden: BECTA 23 (4-5). 1979. 620-G23. Language: ENGLISH Descriptors: LABORATORY POLY VINYL CHLORIDE PIPE LEACHING KINETICS Concept Codes: GENERAL LABORATORY APPARATUS(*01006); BIOCHEM STUD-GENERALt 10060); BIOPHYS-MOLECUL PROP.MACROMOLEC( 10506 ) ; TOXICOL-ENVIRONMNTL.INDUSTR(22506); ENVIRON HEALTH-SEWG DISP.SANITAR( *370 14 ); ENVIRON HEALTH-A IR.WATR.SL POLLN( * 370 1 5 ) 18022531 SCANNING ELECTRON MICROSCOPIC ANALYSIS ON ANTI THROMBOGENICITY OF ARTIFICIAL HEART BLOOD PUMP POLY VINYL CHLORIDE PASTE AVCQTHANE COATED POLY VINYL CHLORIDE PASTE AND POLY URETHANE I MACH I K; FUJIMASA I; SATO N; IWAI N; MIYAKE H: TAKIDO N; NARAJIMA M; KOUNO A; ONO T; ATSUMI K INST. MED. ELECTRON.. FAC. MED.. UNIV. TOKYO, HONGO, BUNKYO. TOKYO. JPN. GTH ANNUAL MEETING OF THE EUROPEAN SOCIETY FOR ARTIFICIAL ORGANS. GENEVA. SWITZERLAND. SEPT. 29-OCT. 1. 1979. ARTir ORGANS (CLEVE) 3 (3). 1979. 301. Coden: ARORD Language: ENGLISH Descriptors: ABSTRACT GOAT ANTICOAGULANT CARDIOVASCULAR-DRUG HYPER COAGULABILITY BLOOD FLOW Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS.REVW(00520); ELECTRON MICROSCOPY(O1058); BIOCHEM STUD - GENERALl 10060): BIOPIIYS-GENERAI. BIOPIIYS TECH( 10504); BI OPHYS - 0 1 OF.NG I NE ER I NG ( - 10511): ANATOMY/HISTOL-EXPERIMENTAL(11104); ANAT0MY/HISIOL-RC- GEN.TRANSPLANT(*11107); MOVEMENT(12100): PATHOLOGY-DIAGNOSTIC- (12504 ); PATHOLOGY-11IERAPY( 12512); CARDIOVASC SYS I-GENL S THUS. ME 1 HS( * 14501 ) ; CARDIOVASC SYST -PHYSIOL. B ICICI IE M( 14 504 ) ; CARDIOVASC SYST-HEART PATHOLOGY(14506); CARDIOVASC SYST-ULU VESS PATHOL(* 14508); BLOOD/BODY FIDS-BLOOD.LYMPH STUD(* 1 5002 ) : PIIARMACOL-BLOOO.IIEMATO AGENT S (* 22008 ) ; PHARMACOL - CARD 1 OVASG SYST(*22010) . B I osystematIc Codes: BOV I DAE(85715) DIALOG F11e5: 8IOSI5 Previews 77-83/Jan BA7502:RRM2402!See FlleS5) (c. BIf R&S 138472 858) User 3GI4 25jan83 2 118 18021328 SIMPLE DETERMINATION OF THE FOLATE BINDING CAPACITY OF PROTEINS BY CHROMATOGRAPHY ON NITRO CELLULOSE AND POLY VINYL CHLORIDE MEMBRANES PRISTOUPILOVA K; PRISTOUPIL T I; PROKE5 J; VULTERIN K INST. HAEMATOL. BLOOD TRANSFU5.. PRAGUE, CZECH, d CHROMATOGR 170 ( 1). 1979.- 221-226. Language: ENGLISH Coden: JOCRA Descriptors: GLUTAMIC-ACID NOTE COW MILK TRITIUM LABELED PTEROYL Concept Codes: RADIATION BIOL-RADTN. ISOTOP TECH(06504); BIOCHEM METH-GENERAL(10050): 8I0CHEM METH-PROTNS.PEPTDS.AM AC(* 10054); BIOCHEM METH-CARBOHYDRATES( 1005B); BIOCHEM STUD-GENERAL(10060): BIOCHEM STUD-VITAMINS(*10063): BIOCHEM STUD-PROTEINS,PEPTIDES,AMINO ACD(*10064); B10PHYS-GENERAL BIOPHYS TECH!10504); BIOPHYS-MOLECUL PROP,MACROMQLEC(*10506); B10PHYS-MEMBRANE PHENOMENA( 1050B); MOVEMENT( 12100); REPRODUCT S Y ST - PHYSI OL , BIOCI 1EM( 16504) B I osys t etna t 1 c Codes: BOV IOAE ( 857 15 ) 1B020724 PROBLEMS WITH CALF BED PADS STAPLES G E N.D. STATE UNIV. AGRIC. APPL. SCI,. FARGO, N.O. 5B102, USA. BR VET J 135 (4). 1979. 3B0. Coden: BVdOA Language: ENGLISH Descriptors: NOTE BACTERIAL ACTION POLY VINYL CHLORIDE HAIRBALL HAIR LOSS DIGESTIVE PROBLEM URINE SCALD Concept Codes; BIOCHEM STUD-GENERAL( 10060) ; DIGESTIVE SYST-PATHOLOGY( * 14006); URIN SYST/EXT 5ECR-PHYSL.BIOCHEM! 1550- 4); INTEGUMENT SYST-PATHOLOGY(+18506); TOXI COL-VETER I NARY(* 22 - 508): PED1ATRICS(2 5000): ANIMAL PRODUCTN-GENL STUDS,METHS(*26 - 502); BACTER1A-PHYSIOLOGY.BIOCHEMISTRY(31000): MED/CLIN MICROBIOL-BACTERIOLOGY!36002); VETERINARY SCI-PATHOLOGY!*3800- 4); VETERINARY SC I-MICROBIOLOGY(38006) B1osys tema tIc Codes: BACTERI A-UNSPECIEI ED!04000): B0VIDAE(857 15) 18020277 SMALL AIRWAY DYS FUNCTION IN MEAT WRAPPERS ASTHMA PRESTEL T H OR; CHESTER E H; TUTHILL T M; SCHWARTZ M d; BARANCIK d I: BOZICH T A VETERANS ADM. MED. CLEVELAND. OHIO, USA. CENT.. CASE WEST. RESER. UNIV.. 75TH ANNUAL MEETING OF THE AMERICAN LUNG ASSOCIATION HELD IN CONJUNCTION WITH THE 74TH ANNUAL MEETING OF THE AMERICAN THORACIC SOCIETY AND THE 67TH ANNUAL MEETING OF THE CONGRESS OF LUNG ASSOCIATION STAFF. LAS VEGAS. NEV.. USA, MAY 13-16, 1979. AM REV RESPIR DIS 119 (4 PART 2). 1979. 231. Coden: ARDSB Language: ENGLISH Descriptors: ABSTRACT HUMAN POLY VINYL CHLORIDE PYROLYSIS FUMES DYSPNEA COUGH CHEST TIGHTNESS SPIROMETRY PLETHYSMOGRAPHY Concept Codes: GENL B1OL-SYMPOSIA,PROCDNGS.REVW(00520): BIOCMEM-GASES!* 10012): BIOPHYS-GENERAL BIOPHYS TECH! 10504); EXTERN EFT-HOT( 106 18); CHORDATE BODY REGNS-THORAX( II 3 1 2 ) ; PATHOLOGY-DIAGNOST1C!12504); PATHOLOGY-INFLAMMATN.INFLAM DIS(- *12500): RESPIRATORY SYS T-GENL STUD,METHS( 16001); RESPIRATORY SYST-PATHOLOGY!* 16006); TOXI COL -ENVIRONMNTL,INOUSTR!*22506 ) ; TEMPERATURE-GENL,METHS!23001); IMMUNOL/IMMUNOCHEM-IMMUNOPATHOL(*34508); ALLERGY!*35500): ENV IRON HEALTH-OCCUPATNL HEALTH(*37013) Blosystemat lc Codes: HOMINIDAE(86215) 18020393 A METHOD FOR STAINING POLY VINYL CHLORIDE IN SECTIONS USING SUDAN IV WILSON N PATHOL. SECT,, CENT. TOXICOL. LAB., IMP. C1IEM. I NO. LTO . ALDERLEY PARK, NR. MACCLESFIELO, CHESHIRE. ENGL.. UK. STAIN TECHNOL 54 (2). 1979. 101-102. Codon: STTEA Language: CNGLISH Descriptors: NOTE TOXICITY INVESTIGATION USE PARATF IN PROCESSING MAYERS IIEMALUM LIPIDS LIPOCIIROME PIGMENTS Concept Codes: MICROSCOPY-GENL,SPECL T E Cl IN I OWES! *01052) ; MICROSCOPY-HISIOL,HISTOCHEM TECH!*01056) ; BIOCHEM METII GCNERA- L(*10050); BIOCHEM METH-LIPI OS( 10056): BIOCHEM SIUO-GENERAL( I - 0060); RESPIRATORY SYST -GENL STUD,METHS( 1600 I ): ROUTES OF IMMUNIZ,INFECT.THERAP(22100); TOXICOl-GENL/EXP STUDS,METHS!*2- 2501); T0XIC0L-ENVIR0NMN7I . tndHSTP(?eenr1 DI ALO He5: BIOSIS Previews 77-03/Jon BA7502; RRM2402 (See FIltfK) (c. BIOS, R&S 138473 858) User 3614 25Jan83 2 119 18012399 SOME PROBLEMS INVOLVED IN RECOGNIZING TERATOGENS USED IN INOUSTRY BUFFLER P A DEP. PREV. MED. COMMUNITY HEALTH. UNIV. TEX. MED. BRANCH. GALVESTON. TEX. 77550. USA. KLINGBERG, M. A. AND J, A. C. WEATHERALL (ED.). CONTRIBUTIONS TO EPIDEMIOLOGY AND BIOSTATIST1CS. VOL. 1. EPIDEMIOLOGIC METHODS FOR DETECTION OF TERATOGENS. IX+203P. S. KARGER: BASEL. SWITZERLAND; NEW YORK. N.Y.. USA. ILLUS. MAPS. PAPER. ISBN 3-8055-2809-2. CEPBD O (0). 1979. PI 18-137, Coden: Language: ENGLISH Descriptors: REVIEW HUMAN VINYL CHLORIDE INHALATION CHROMOSOMAL ABERRATIONS CIRCULATING. LYMPHOCYTES SPONTANEOUS ABORTION MUTAGEN Concept Codes: GENL BIOL-INFRMTN.DOCU.COMP APPL(*00530); CYTOLOGY/CYTOCHEM-HUMAN(*02508); GENET ICS/CYTOGENET-HUMAN(*03508); SOCIAL BIOL/IIUMAN EC0L0GY(0- 5500); BIOCHEM STUD-GENERAL( 10060); PATHOLOGY-DIAGNOSTIC( 1250- 4); PATHOLOGY-NECROSI5( 12510); BLOOD/BOOY F LDS- BLOOD CELL STUDS(* 15004 ) ; RESPIRATORY SYST-PATHOLOGY( 16006); REPRODUCT SYST-GENL STUDS.METHS(16501); REPRODUCT SYST-PATHOLOGY(*16506) ; TOXI COL -ENVIRONMNTL,INDUSTR(* 22506); DEVELQPMNTL BIOL-PATIIOLOGICAL(*25503); DEVELOPMNTL BIOL-DESCRIP TERATOL(*25552); PUB HEALTH-ADM INISTR.STAT ISTICS(*37010); ENVIRON I IEALTH-A IR.WATR.- SL POLLN(37015); EPI DEMIOL-MISCELL STUDIES(3705G) Blosystematlc Codes; HOMINIOAE(86215) 18003185 EFFECTS OF ELECTRIC ENVIRONMENTAL FACTORS ON THE BEHAVIOR OF CAGED HONEY- BEES ALTMANN G; WARNKE U FACHR. ZOOL.. FACHGER. 16 UNIV. SAARLANDES, 6600 SAARBRUECKEN. W. GER. ANZ SCHAEDLINGSKD PFLANZEN5CIUJTZ UMWELT5CHUTZ 52 (2). 1979. 17-19. Codon: ASPUC Language: GERMAN Descriptors: RECTAL BLADDER METABOLIC RATE POLY VINYL CHLORIDE CAGE STEEL CAGE Concept Codes: GENERAL LABORATORY METHODS(01004); GENERAL LABORATORY APPARATUS(01006); BEHAVIOR BIOL -ANIMAL BEHAVIOR(*0- 7003); BIOCHEM STUO-GFNERAL(10060); EXTERN EFF-CLECTR,MAGNET.- GRAVITY(* 10610); DIGESTIVE SYST-PHYSIOL.BIOCIIEM( 14004); ECONOM ENrOMOL-SERICULTURE(*60020); INVERTU PHYSIOL- 1NSECTA-PHYSIOL(- *64076); INVERTB BODY-SPECIAL ORGANS(6421B) Blosystematlc Codes: HYMENOPTERA(75326) TOXICOL APPL PHARMACOL TXAPA 49 (1). 1979. 15-22. Coden: Language: ENGLISH Dose - response data for the Induction of angiosarcoma In rats exposed to various levels of vinyl chloride (VC) together with attendant b1otransformatI on data were used to estimate the risk of developing angiosarcoma In persons exposed to VC. Since a b1otransformat1 on product of VC. not VC per se . Is responsible for the Induction of angiosarcoma, the body surface area of people relative to rats was used to estimate the dose of the carcinogen b1otransformed from VC by the former. Four models were used to extrapolate the data. Using a probIt model. 10 hepatic angiosarcomas were predicted to occur In a recently reported epidemiological cohort of 9677 workers whereas 5 have occurred. Linear models and that based on the equation. Risk = 1 - e-.bota.x. where x * dose, do not appear as reliable. For an 8 h day, 5 days/wk, 35 yr tIme-we1ghted/average exposure of 1 ppm. the predicted Incidence of hepatic angiosarcoma using the prob 1 t model Is 1.5 .times. 10-8. Descriptors: CARCINOGEN BIO TRANSFORMATION BODY SURFACE AREA LIVER PROBlT MOOEL Concept Codes: MATHEMATIC BIOL/STAT I ST IC METH(04500); BIOCHEM STUD-GENERAL(100G0); PHYSIOLOGY-COMPARATIVE(12003); DIGESTIVE SYST-GENL STUDS,METHS( 14001); DIGESTIVE SYST-PAT IIOL- OGY(* 14006); CARD IOVASC SYST-GENL STUDS.METHS( 14501); CARD IOVASC SYST-BLD VESS PATHOL(* 14508); BONE.JNTS.FASC.CONN/- ADIP-GENL( 10001): BONE.JNTS.FASC.CONN/AD IP- PATHOL( 18006); T0X1C0L-ENVIRONMNTL,INDUS TR(* 22506); NEOPLSMS/NEOPL AGNTS-CAR- ClNOGENSl*24007); PUB HEALTH-ADMINISTR.STAT I ST ICS(37010): ENVIRON HEALTH-OCCUPATNL HEALTH(*37013): ENVIRON HEALTH-A IR.W- ATR.SL POLLN(37015); EPIDEMIOL-ORGANIC DIS.NEOPLASMS(*37054 ) Blosystematlc Codes: HOMINIDAE(86215); MUR IOAE(86375 ) 60074644 RISK OF ANGIO SARCOMA IN WORKERS EXPOSED TO VINYL CHLORIDE AS PREDICTED FROM STUDIES IN RATS GEHRING P J; WATANABE P G; PARK C N TOXICOL. RES. LAB.. DOW CHEM, USA, MIDLAND, MICH. 48640, USA, DIALOG : BI05IS Previews 77-83/dan BA7502;RRM2402(See FI 1e5 (c. BIOS R&S 138474 858) User 3614 25Jan 2 120 60073207 STUDY OF FUNGAL RESISTANCE OF SOME LIQUID PLASTIFIERS UTILIZED IN POLY VINYL CHLORIDE COMPOSITION LI NOVIT 5KAY A V M: KURGANOVA L N; ANISIMOV A A; BOCHKAREVA G G; OVCHINNIKOV YU A; KOMOLOVA V M GORKI STATE UNIV.. GORKI. USSR. PRIKL BIOKHIM MIKROBIOL 15 (1). 1979. 70-73. Coden: PBMI A Language: RUSSIAN Fungal resistance of liquid plastlflers, dlesters of sebaclc, adipinic and phthallc acids. was measured with respect to the pH of culture fluids before and after the sample exposure together with the mold Penlcllllum funlculosum. The composition of acid metabolites of the tost mold was determined by descending paper chromatography. Plastlflers based on adipinic and sebaclc acids underwent destruction by the mold. This was Indicated by an accumulation of acid groups In the medium. Phthalates In the liquid C-free media were fungus-res Istant. Descriptors: PEN1CILLIUM-FUNICULOSUM SEBACIC-ACID ADIPINIC-- ACID PHTHALIC-ACID Concept Codes: COMPARATIVE BIOCHEM-GENL STUD IES( 10010): BIOCHEM METH-GENERAL(10050): BIOCHEM STUD-GENERAL(10060): BIOPHY S-GENERAL BIOPHYS TECH( 10504); MOVEMENT( 12100); METABOLISM-GENL STUD,METAB PATHW(*13002); MICROBIOLOG APPARAT,METHS,MEDIA(32000); FOOD/INDUS MICRO-BIODEGRAD.DETER(- +39006); PLANT PHYSIOL-METABOLISM(+51519) Biosystemat1c Codes: DEUTEROMYCETESf15500) Descriptors: RAT LIVER MICROSOME METYRAPONE TETRA HYDRO FURAN TWEEN QO VINYL CHLORIDE METHYL Cl IOL AN 11 IRENE 7 8 UC.N70 FLAVONE CYTOCHROME P -408 MONO OXYGENASE Concept Codes: CYTOLOGY/CYTOCHEM-ANJMALf+02506): GENETICS/C- YTOGENE T- SEX OIF F ERENC(035 tO); MATHEMATIC BIOL/STATISTIC ME TH(04 500); COMPARATIVE BIOCHEM-GENL STUD IES( 10010): BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-NUCL ACD,PURNS.PYRMf1O062); BIOCHEM STUD-PROTEINS,PEPTIDES.AMINO ACD(10064); BIOCHEM STUD-PORPHYRNS.BILE PIGM(IOOGS): BIOCHEM STUD-LIPIDS( 10066); BIOPHYS-MOL ECUL PROP.MACROMOLEC( 10506 ) ; ENZYMES-GEN,COMPAR STUD.COENZYMS(10802): ENZYMES-METHOOS(10804); ENZYMES-CHEM.PH YSICAL STUDIES! + 10806) : ENZYMES-PHYSIOLOGI CAL STUD IES(*10008): ANA TOMY/HISTOL-MICRO.ULTRAMICRSCf 11108): METABOLISM-GENL ST1JD- .METAB PATHWf 13002): METABOLlSM-LIPI OS( 13006); METABOLISM-PRO- TNS.PEPTDS.AM ACOS! 13012); DIGESTIVE SYST - PHYSIOL.BIOCHEM( 140- 04): PHARMACOL-DRUG METAB.METAB STI MU(+22003) : PHARMACOL-NEUR- 0PHARMAC01.0GY(2202 4 ); TOXI COL-GENL/EXP STUDS.METHS( '2 2501 ); TOXICOL-PHARMACOLOGICALf+22504 ); IN VITRO STUDS-CELLULR.SUBCE- LL(32600) BIosystemattc Codes: MURIDAE(86375) 68070713 DI CHLORO-P-NITRO ANISOLE 0 DE METHYLASE PART 2 EVIDENCE FOR SEPARATE ETHANOL INHIBITED AND PHENO BARBITAL INDUCIBLE ENZYMES HULTMARK D; SUNDH K; JOHANSSON L; ARRHENIUS E DEP. MICROBIOL., UNIV. STOCK!!.. S-106 91 STOCKHOLM. SWED. eiOCHEM PHARMACOL 28 (10). 1979. 1587-1590. Coden: BCPCA Language: ENGLISH Some properties of the monooxygenase activity measured In teh recently described d1ch1oro-p-nItroan 1 so 1e 0-demothy1ase assay were studied In rat liver mtcrosomes. Enzyme activity In control mtcrosomes was Inhibited by ethanol (150 (median Inhibitory dose) = 5 mM). The small slope of the Inhibition curve was evidence for a heterogenous enzyme system, with at least I enzyme being highly sensitive to ethanol Inhibition. A number of other water-mI sc lb 1e organic solvents Inhibited the reaction; totrahydrofuran was most efficient (ISO - O.R mM). Tween BO gave only weak Inhibition at concentrations up to 4 mg/ml. Vinyl chloride was a strong Inhibitor. Phenobarb1ta1 pro treatmentof the rats Increased f)-domethyIase activity at least 24-fold and made the enzyme highly, sensitive to metyrapone inhibition but .not to ethanol, P-448 was not Involved In the reaction since 3-me thy 1cho1 antrene protreatment or addition of 7, B-benzof1avone produced no effect. Only small differences were found between the enzyme from male had female rats. DIALOG F11e5: BIOSIS Previews 77-83/Jan BA7502;RRM2402(See Flle55) (c. BIOSIS R&S 138475 58) User 3814 2S)anB3 2 121 6B070692 PHARMACO KINETICS OF HALOGENATED ETHYLENES IN RATS FILSER J G: BOLT H M INST. TOXIKOL., UNIV. TUEB., LOTHAR MEYER-BAU. WILHELMSTR. 56. D*7400 TUEBINGEN 1. W. GER. ARCH TOXICOL 42 (2). 1979. Language: ENGLISH 123-136. Codon: ARTOD Inhalation pharmacokinetics of the halogenated ethylenes vinyl fluoride (VF), vinylIdene fluoride (VF2), vinyl chloride (VC1), vinyl Idene chloride (VC12")i els- and trans-dlchloroethylene (cts-DCE and trans-DCE), trtch1oroothy- lene (Trl), perch 1oroethy 1ene (Per) and vinyl bromide (VBr) were comparatively studied In the rat. Rats wore exposed In a closed Inhalation system to various Initial atmospheric levels of halogenated ethylenes, and the decline of atmospheric concentration was followed using gas chromatographic analysis. From pharmacokinetic analysis of the experimental curves the following general patterns of the halogenated ethylenes were derived.' Distribution of the compounds in the organism and In the gas phase was determined by physical factors. A relation of the equilibrium constants with the volatilities of the compounds. expressed by the boiling points. may be used; compounds with a low boiling point are enriched In tissues less than those of a higher boiling point and vice versa. Compounds with high accumulation In tissues (Trl, Per) need more time for completion of the equilibration process than more volatile compounds. Metabolic elimination of halogenated ethylenes Is a saturable, dose-dependent process. If animals are exposed to atmospheric concentrations of a halogenated ethylene which exceed the point of saturation, elimination Is determined by a zero-order law, l.e.. Its rate is Independent of the concentration of the compound. Below saturation normal Ist-order kinetics apply. If the rate of metabolic elimination Is related to the concentrations of the compounds In the tissue compartment, very similar rates for ist-order elimination of the different halogenated ethylenes are found. A common rate limiting factor applicable for the lower concentration range was suggested. The Vmax of metabolic elimination of halogenated ethylenes which are reached above the saturation points depend on the chemical structures of the Individual compounds. With the exception of Trl. further halogen substitution inhibits metabolic conversion. Of the halogenated ethylenes, VF2 and Per were slowly metabolized. The data necessary for calculation of tho rates of metabolism of halogenated ethylenes In rats at a given concentration of atmospheric exposure were provided. Descriptors: VINYL FLUORIDE VINYLIOENE FLUORIDE VINYL CHLORIDE VINYLIDENE CHLORIDE CIS 01 CHLORO ETHYLENE TRANS 01 CHLORO ETHYLENE TRI CHLORO ETHYLENE PER CHLORO ETHYLENE VINYL BROMIDE Concept Codes: COMPARATIVE BIOCHEM-GENL STUD IE5( 10010); BIOCHEM-GASES(10012); BIOCHEM METH-GENERAL(10050); BIOCHEM STUO-GENERAL( 10060) : BIOPHY S - GE NE R At, BIOPHYS T ECI l( 10504 ) : BI0PHY5-M0LECUL PROP.MACROMOLEC(*10506); MOVEMENT(12lOO); METABOLISM-GENU STUD,MET AO PATHW(13002); RESPIRATORY SYST-PHYSIOL.BIOCHEM( 16004); TOXI COL-GENL/EXP STUDS,METHS(*22- 501): NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(* 2 4007) B 1 05vs t ema t Ic Corfos 68066609 INSECT CONTROL WITH CARBON DI OXIDE IN A SMALL STACK OF BAGGED GRAIN IN A PLASTIC FILM ENCLOSURE BANKS H J; SHARP A K DIV. ENTOMOL.. CSIRO, CANBERRA. A.C.T. AUST. AUST J EXP AGRIC ANIM HUSB Codcn: AAAHA 19 (96). 1979. 102-107. Language: ENGLISH The use of C02, added as dry Ice. was demonstrated as a means of disinfestation of bagged wheat and rye enclosed In a PVC [polyvinyl chloride] membrane. The bag stack was dosed with dry Ice giving an atmosphere of about 60% C02. C02 levels were maintained over 2? days with additional charges of dry Ice added directly on top of the stack or enclosed within a polystyrene box to regulate the C02 release rate. A natural Infestation of Rhyzopertha domlnlca with small numbers of other stored product pest species was controlled. with complete mortality of adult Insects, but slight survival of some early stages of R. domlnlca. Some hymenopterous parasttolds, An 1sopteroma1 us calandrae and Choetosplla elegans, survived tho treatment, apparently as pupae. Tho treatment was successful under conditions where other methods of pest control were inappllcalbe because of difficulty or expense of application, as In a small bulk (2.8 tonnes), at low temperature (1 1 - 13.degree. C). when the commodity Is close to working areas and when pesticide residues are not perm 11 ted, Descriptors: RHYZOPERTHA-DOMINICA ANI SOPTEROMALUS-CALANDRA CHOETOSPILA-ELEGANS WHEAT RYE PESTICIDE POLY VINYL CHLORIDE MORTALITY Concept Codes: BIOCHEM-GASE$(10012): BIOCHEM STUD-GENERAL( 1 - 0060): PATHOLOGY-NECROSIS(12510): FOOD TECH-CEREAL CHEM!STRY( 135 10) : TOOD TECH-PREP . PROCESSNC,. STORAGE ( 1 3532 ) : TOXICOL-GENL/EXP STUDS . METHS ( 2250 1 ) ; AGRONOMY - C.R A I N CROPS(*52- 504 ); PEST CONTRL GENL/PESTICS/HERBtCS(* 546001; ECONOM ENTOMOL-STORED PR0DUCTS(*60008): ECONOM ENTOMOL-CHEM PHYS CONTRL(*G0016); INVERTB PHYSIOL-I NSECTA-PATHOL( 64078) B losystematIc Codes: GRAMINEAE(25305); COLEOPTERA(75304 ); HYMENOPT ERA(75326); ABSTRACTS OF ENTOMOLOGY(96000) DIALOG Flle5: BIOSIS Previews 77-83/den BA7502:RRM2402(See rile55) (c. BIOSIS 19E R&S 138476 User 3614 25jan83 2122 68064661 THE INFLUENCE OF SOIL TEMPERATURES AS CONTROLLED BY MULCHING ON GROWTH AND DEVELOPMENT IN MAIZE IREMIREN G 0; MILBOURN G M NIGER. INST. OIL PALM RES., P.M.B. 1030. BENIN CITY, NIGER. ANN APPL BIOL 91 (3). 1979. 397-402. COden: AABIA Language: ENGLISH An Increase In soil temperature (at 5 cm) of I .5 - 4.o.degree. C occurred for 84 days after sowing maize with a surface mulch of clear polyvinyl chloride (PVC) sheet compared with a ground chalk mulch. This rise In soil temperature resulted In a 15-day advance In both emergence and the commencement of tassel prlmordla d1fferent1 at1 on. with full tassel differentiation being 24 days earlier. The PVC mulch also led to 13 days earlier silking, with the spread In date of silking being reduced from 19 to 8 days, this effect being similar for both a double-cross and a single-cross hybrid. Dry matter yields of whole crop silage and of grain were Increased by M and 39%, respectively, with PVC mulch due to the earlier development of a complete cahopy with a longer grain fill per 1od. Descriptors: POLY VINYL CHLORIDE TASSEL PRIMORDIA DIFFERENTIATION SILKING DRY MATTER YIELD GRAIN SILAGE Concept Codes: BIOCHEM STUD-GENERAL(10060); EXTERN EFF-TEMPERATURE(10614); TEMPERATURE-GENL,MET1IS(23001); PLANT PHYSI0L-TEMPERATURE(*51503); PLANT PHYSIOL-GROWTH,DIFFRENTI AT - (*51510); PLANT PHYSIOL-REPRODUCT I0N(51512): AGRONOMY-GRAIN CR0PS(*52504 ); AGRONOMY - FORAGE CROPS , FODDER(*52506); SOIL SCI-FERTILITY.APPLIED STUDS(*52807) B Iosystema11c Codes: GRAMINEAE(25305) 680G1939 V1NYLIDENE FLUORIDE METABOLISM AND INDUCTION OF PRE NEOPLASTIC HEPATIC FOCI IN RELATION TO VINYL CHLORIDE STOCKLE G; LAIB R d: FILSER J G; BOLT H M INST. TOXIKOL.. UNIV. TUEB.. WILHELMSTR. 56. 0-7400 TUEBINGEN-t, W. GER. TOXICOL LETT (AMST) 3 (6). 1979. 337-342. Coden: TOLED Language: ENGLISH The velocity (Vmax) of metabolic elimination of vinylIdene fluoride from the rat Is 1/100 that of vinyl chloride. In the light of the current concept of metabolic activation of halogenated ethylenes, this may explain tho much lesser ability of vlnylldone fluoride, compared with vinyl chloride, to Induce pre-neop1 ast1c ATPase-def1cIent hepatic foci In newborn rats. Descriptors: RAT CARCINOGENS Concept Codes: COMPARATIVE BIOCIIEM-GENL STUD IES( 100 10): BIOCHEM STUD-'GENERAL( 10060) : BIOCHEM S t UD - PRO T E I NS . PE P T I DE S . A - MINO ACD( 10064); ENZYMES-METHODS( 10804); ENZYMES-PHYS1DLOGICAL STU0IES(* 10808); MOVEMENTS 12100); METABOLISM-GENL STUD.METAB PATF1W(* 13002); DIGESTIVE SYST-GENL STUDS.METHS( 14001): DIGESTIVE SYST-PATHOLOGY(* 14006); TOXI COL-GENL/EXP STUDS.METH- 5(* 22501); NE0PLSM5/NE0PL AGNTS-CARCI NOGENS(*24007); PEDIATRI CS (25000) R tnran t- { r- *7 * WHOlOUf 68061880 ETHANOL INHIBITION OF VINYL CHLORIDE METABOLISM IN ISOLATED RAT HEPATOCYTES HULTMARK 0: SUNDH K; JOHANSSON L; ARRHENIUS E DEP. MICROBIOL., UNIV. STOCKH.. S-106 91 STOCKHOLM. SWED. CHEM-BIOL INTERACT Language: ENGLISH 25 (1). 1979. 1-6. Coden: CBINA Isolated rat liver cells convert (14C)vlnyl chloride (a carcinogen] Into non-volatlie metabolites. This metabolism Is not Increased by in vivo pretreatment with phenobarb I ta 1 . It Is sensitive to Inhibition by ethanol. which at a concentration of 4 mM Inhibits vinyl chloride metabolism to 50% In hepatocyte suspensions. The metabolic activity Is NADPH-dependent and Is localized In the microsomal fraction of the liver. The enzyme Is strongly inhibited by te1rahydrofuran. Indicating that It could be Identical to an ethano1 - 1nductb1e cytochrome P-450. Descriptors: TETRA HYDRO FURAN ENZYME INH1BI TOR - DRUG ETHANOL PHENO BARBITAL METABOLIC-DRUG CARCINOGEN CYTOCHROME P-4S0 NAOPH Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506); RADIATION BIOL-RADTN,ISOTOP TECH(06504 ); COMPARATIVE BIOCHEM-GF NL STUD 1ESf10010); BIOCHEM STUD-GENERAL( 10060): BIOCHEM STUO-NUCL ACD,PURNS,PYRM( 10062); BIOCHEM STUD-PROTEI NS.PEPTIDES.AM I NO ACD( 10064); BIOCHEM STUD-PORPHYRNS.BILE PIGM( 10065);, ENZYMES-GEN.COMPAR STUD.COENZYMS(10802): PATHOLOGY - THERAPY( 1 - 2512): METABOLISM-GENL STUD,ME T AB PATHWf 1 3002 ) ; DIGESTIVE SYST-PHYSIOL.BIOCHEM(* 14004): PHARMACOL-DRUG ME T AB.ME T AB ST I MU(* 22003); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(*24007); NEOPLSMS/NEOPL AC.NTS-THERAP,AGNT(24008); IN VITRO STUDS-CELLU- LR,SUBCELL(32600) B iosystemattc Codes: MUR I DAE(86375) DIALOG F 1 1e5: BIOSIS Previews. 77-83/Jan BA7502;RRM2402(See F11e55) 68058807 TRANSIENT IN-VIVO PROTEIN ADSORPTION ONTO POLYMERIC BIO MATERIALS IHLENFELD J V; COOPER S L 3M CO.. 3M CENTER, ST. PAUL. MINN. 55101. USA, J BIOMED MATER RES 13 (4). 1979. 577-592. Codon: JBMRB Language: ENGLISH The adsorption of albumin, .gamma.-g1obu11n and fibrinogen was measured on 3 ex vivo polymeric shunt surfaces [polyvinyl chloride (PVC). Silastic and segmented polyether urethane (Blomer)] exposed to flowing heparinized, canine blood In vivo. Small amounts of radiolabeled proteins wore Infused Into anesthetized mongrel dogs and the deposition of radioactivity on the walls of femoral arteriovenous shunts was followed with time for 2 h following Initial blood-polymer contact. Previously, transient In vivo platelet and fibrin deposition onto PVC. Silastic and Blomer was measured by a similar technique In the absence of anticoagulant. A t1 mo-dependent phase of thrombus deposition followed by thromboembolism was observed on the PVC and Silastic shunt surfaces but not on the Blomer surface. In relation to PVC and Silastic studies fibrinogen adsorption predominated Initially; It subsequently desorbed and was replaced by albumin and .gamma.-g1obu11n. On Blomer the adsorption of all 3 proteins Increased with time following blood contact and fibrinogen was less prominent Initially. The PVC surface became passivated with respect to further thrombogenesIs after 60 min exposure to flowing blood; a higher fraction of albumin was present on the surface compared to that at earlier blood contact times. Apparently rearrangement or adsorbed protein species occurs with time on polymer surfaces exposed to flowing blood in vivo. Early and predominant fibrinogen absorption Is apparently Important In the thrombogentc and embolic events observed on the PVC and Silastic shunt surfaces In vivo. Descriptors: DOG BLOOD FEMORAL ARTERIO VENOUS SHUNT PLATELET HEPARIN ANTICOAGULANT FIBRINOGEN GAMMA GLOBULIN ALBUMIN FIBRIN POLY VINYL CHLORIDE SILASTIC POLY ETHER URETHANE BIOMER THROMBUS Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02006); RADIATION BIOL-RADTN,ISOTOP TECH(0GG04); COMPARATIVE BIOCHEM-GENL STUDIES! 10010); BIOCHEM STUD-GENERAL( 10060); BIOCHEM STUD-PROTEINS,PEPTIDES.AMINO ACD(10064); BIOCHEM STUD-CARBOHY- DR.(IOOGB); BIOPHYS-GENERAL BIOPHYS TECHt10504); BIOPHYS-MOLE- CUL PROP.MACR0M0LEC( 10506); B10P1IYS-BIOENG1NECRING(* 105 I 1 ); ANAT OMY/111STOL-EXPERIMENTAL( 11104); ANATOMY/HISTOL-REGEN.TRANSPLANT( I 1107); CHORDATE BODY REGNS-E- XTREMITIES( 113 18): PHY5 IOLOGY-COMPARAT IVE(12003); MOVEMENT(12- lOO); PATHOLOGY-COMPARAT IVE( 12503); METABOLISM-GENL STUD.ME T AR PATHWf 13002); METABOLISM-CARBOHYORATES( 13004); METABOLISM- PR - OTNS . PEPTDS . AM ACOS ( 1 30 12 ) ; CARDIOVASC SYST-C.ENL STUDS. METHS- (14501); CARDIOVASC SYST-PHYSIOL.BIOCHEM(14504); CARDIOVASC SYST-BLD VESS PATHOL(*14508); BLOOD/BODY FLOS-BLOOD.LYMPH STUO(15002); BLOOD/BODY FLDS-BLOOD CELL STUOS(* 15004); NERVOUS SYST-GENL STUDS.METHS(20501): PHARMACOL - BLOOD, IIEMATO AGENTS{22008); PHARMACOL-CARDIDVASC SYST(220I0); PHARMACOL-NE- UROPHARMACOLOGY(22024); IN VITRO STUDS-CELLULR.SUBCELL(32600) B iosystematIc Codes; CANIDAE(85765) DIALOG Flle5: BIOSIS Previews 77-83/dan BA7502;RRM2402(See FMc55) (c. BIOSIS 1982) (Item 420 o R&S 138478 83 2 124 60057721 THE SEARCH FOR EXPIRATORY OBSTRUCTION IN MEAT WRAPPERS STUDIED ON THE JOB KRUMPE P E: FINLEY T N; MARTINEZ N DEP, MED.. UNIV. CALIF.. DAVIS. CALIF., USA. AM REV RESPIR DIS 119 (4). 1979. 611-610- Coden: ARDSB Language: ENGLISH The respiratory history questionnaire responses and maximal expiratory flow-volume curves In meat wrappers and control subjects who worked 12 . + 3 yr at their occupation were studied; all subjects regularly cut polyvinyl chloride film with a hot wire and were exposed to pyrolysis fumes on the Job. One half of the subjects were studied at room temperature and the rest were studied In a refrigerated work area (2.degree. C). Compared to the control subjects. the wrappers demonstrated a greater prevalence of respiratory complaints and related eye Irritation after exposure to fumes. Baseline values for forced vital capacity [FVC], forced expired volune In 1 s [FEVIs] and expiratory flow at 50*/. of vital capacity exceeded 707. of predicted values In all but 1 of 30 wrappers. After one 8-h shift, FVC and FEVIs remained unchanged (, + -. 107.) In 15 wrappers; maximal flow at 507. of vital capacity decreased by 10% or more In 4 of 15 wrappers (26%). After work for 1 wk. FEV was decreased by 10% or more In 2 of 30 wrappers (7%). FEVIs was unchanged and expiratory flow at 50% of vital capacity was decreased In 7 of 30 wrappers (13%). Changes In the group of wrappers were not significantly different from the control groups when studied by analysis of variance. The wrappers' responses under refrigerated conditions were not different from those studied at room toinporature. Although certain hypersens 111ve persons may develop bronchospasm after exposure to fumes of polyvinyl chloride film, documentation of normal base-line pulmonary function studies and the low Incidence of reactive bronchospasm after on-the-job exposure to polyvinyl chloride pyrolysis fumes arguo against the presence of a major respiratory hazard In this occupation. Descriptors: HUMAN RESPIRATORY PROBLEM EYE IRRITATION BRONCHO SPASM POLY VINYL CHLORIDE PYROLYSIS Concept Codes: MATHEMATIC BIOL/STAT I ST IC MFTH(04500); SOCIAL BIOL/HUMAN ECOLOGY(05500): BIOCHEM STUD-GENERAL(10060); EXTERN EFF-C0LD(10616); EXTERN EFF-HOT(I0618); MOVEMENT(12100); PATHOLOGY-INFLAMMATN,INFLAM DIS( 12508); FOOD TECH-MEAT,MEAT BY-PRODUCTS( 13516); FOOD TECH-PREP,PROCESSNG,STORAGE( 13532 ) ; RESPIRATORY SYST-GENL SIUD.MCTHS(1 GOO 1); RESPIRATORY SYST-PMYSIOL.BIOCtIEM(16004); RESPIRATORY SYST-PATHOLOGY(* 1600- 6); MUSCLE SYST- PATHOLOGY( 17506); SENSE ORGANS-PHYS1OL.BIOCHE- M(20004 ) ; SENSE ORGANS - PATHOLOGY(*20006); TOXI COL-ENVIRONMNTL- ,I NOUS T R(*22506); TEMPERATURE-GENL.METHS(23001); TEMPERATURE - - CRY0BI0L0GY( 23004 ) ; I MMUNOL/1MMUNOCHEM - I MMtJNOP A TIIOL ( 34 500 ) ; ALLERGY!35500): ENVIRON HEALTH-OCCUPA1NL HEAL111(*37013) Blocystemat Ic Codes; VERTEBRALA-UN5PECIFIEP(65150); II0M1NID- AE(8G215) NFLMS L It; REISZNER K 0; WEST P W ENVIRON. SCI. INST.. CIIEM. OEP., ROUGE. LA.. 7QB03, USA. LA. STATE UNIV., BATON ANAL CIIEM 49 (7). 1977. 994-998, Language: ENGLISH Coden: ANCHA A method for measuring the exposure of personnel to vinyl chloride was developed which utilizes the permeation technique for sampling. The vinyl chloride that permeates the membrane Is trapped on activated charcoal which Is removed Tor subsequent determination by gas chromatography. The monitor Is about the size of a standard film badge. weights < 35 g and requires no source of power. The method Is Insensitive to temperature and humidity and Interferences. The method Is Is free of significant Ideally suited to personal monitoring programs required by OSHA [Occupational Safety and Health Act Of 1970) regulations, because the analytical data represent a time-weighted-average exposure and require no further data reduction step. Descriptors; HUMAN OCCUPATIONAL HAZARD Concept Codes: GENL BI0L -1NST I TUT , ADM1N . LEC.I SLN( 00508 ) : SOCIAL BIOL/HUMAN ECOLOGY(05500): BIOCHEM METH-GENERAL(10050): BIOCHEM STUO-GNERAL(10060); BIOPHYS-GENERAL BIOPHYS TECH( 10504); MOVEMENT( 12 100): TOXI COL-GENL/EXP STUDS.METMS( 2 2501); TOXICOL-ENVIRONMNTL.INDUSTR(*22506); PUB HEALTH-ADM IN I - STR.STATI5TICS(37010); ENVIRON HEALTH-OCCUPATNL HE ALTH(370 1 3 ) ; ENVIRON HEALTH-AIR.WATR.SL POLLN('37015) B losystemat I c Codes: HOMINIDAE(86215 ) 68057695 PERSONAL VINYL CHLORIDE TECHNIQUE FOR SAMPLING MONITORING DEVICE WITH PERMEATION DIALOG F I I o5 : BIOSIS Previews. 77-03/dan BA7502 : RRM2402 (See F 11 e55) (c. BIOSIS 1982) (Item 422 of 858) User R&S 138479 68055039 METABOLISM OF CARBON-14 LABELED AND CHLORINE-36 LABELED VINYL CHLORIDE IN-VIVO AND IN-VITRO GUENGERICH F P; WATANABE P G DEP. BIOCHEM.. CENT. ENVIRON. TOXICOL.. VANDERBILT UNIV. SCH. MED., NASHVILLE, TENN. 37232. USA. BIOCHEM PHARMACOL Language: ENGLISH 2B (5). 1979. 589-596. Coden: BCPCA Label from [14C]v1ny1 chloride was covalently bound to protein and nucleic acids In vivo and In vitro In the presence of rat liver microsomal fractions or highly purified cytochrome P-450 and NADPH-cytochrome P-450 reductase preparations. The ratio of bound to total non-volatile metabolites Increased In going from the In vivo to the microsomal to the purified system. [36C1]vtnyl chloride was metabolized by mlcrosomes and highly purified systems. No label was bound and most could bo accounted for as C1-. Phenobarb I ta 1 pretreatment of rats did not Induce total metabolism of vinyl chloride in vivo at either 10 or 250 ppm exposure levels. Binding to protein and RNA was enhanced at the 10 ppm but not the 250 ppm level. Phenobarb1ta1 pretreatment Increased the In vitro microsomal conversion of vinyl chloride to both total and bound metabolites. A sizeable fraction of the label of[14C]vlnyl chloride metabolized In vivo was recovered In the microsomal fraction of the liver, but sodium dodecyl sulfate polyacrylamide gel electrophoresis of In vitro Incubations Indicated that the metabolites were distributed among many microsomal proteins and not localized to cytochrome P-450. Evidence was obtained for the metabolism of the suspected vinyl chloride metabolite chioroethy 1ene oxide by microsomal epoxide .hydratase. The epoxide hydratase Inhibitor 3,3,3-trI chioropropy1ene oxide, which blocks the microsomal degradation of ch1oroethy 1ene oxide. did not enhance the level of vinyl chloride bound to either protein or adenos1ne. Descriptors: RAT LIVER CARCINOGEN CYTOCHROME P-450 NADPH CYTOCHROME P-450 REDUCTASE PHENO BARBITAL CENTRAL DEPRESSANT PROTEIN RNA ADENOSINE SODIUM DODECYL SULFATE POLY ACRYLAMIDE GEL ELECTROPHORESIS CHLORO ETHYLENE OXIDE MICROSOMAL EPOXIDE HYDRATASE 333 TRI CHLORO PROPYLENE OXIDE Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(*02506); RADIATION BIOL-RADTN,ISOTOP TECH(06504); BIOCHEM STUD-NUCL ACO.PURNS.PY- RM( 10062); BIOCHEM STUD-PROTEINS.PEPTIDES,AM I NO ACO( 10064 ) : BIOCHEM STUD-PORPHYRNS.BILE PIGM(100G5): BIOCHEM STUD-L1PIDS(- 10066); BIOCHEM STUD-CARBOHYDR.(10068): MINERALS!10069): BIOPHYS-GENERAL BIOPHYS TECH!10504); BIOPIIYS-MOLECUL PROP,MACROMOLEC(+10506); ENZYMES-PHYSIOLOGICAL STUD IES( 10808 ) : MOVEMENT(12100); META80LISM-GENL STUD.MET AB PATHW( 13002); METABOLISM.NUCL ACD.PUR I NS,PYRIM(13014); DIGESTIVE SYST-GENL STUDS . ME I list 1400 1 ) : DIGESTIVE SYST-PHYS 101. . BIOCHEM! 14004 ) ; NERVOUS SYST-GENL STUDS.METHS(20501); PHARMACOL-NEUROPHARMACO- LOGY(22024 ); TOXI COL-GENL/EXP STUDS,METHS(+22501); NEOPLSMS/N- EOPL AGNTS-BIOCHEM!+24006); NE0PL5MS/NE0PL AGNTS-CARC INOGENS(- +24007); IN VITRO STUDS-CELLULR.SUBCELL(32600) B1osystematIc Codes: MURIDAE(86375) 60046563 EMBRYO TOXIC AND TERATOGENIC ACTION OF VINYL CHLORIDE MIRKOVA E: MIKHAJLOVA A; NOSKO M INST. HYG. OCCUP. DI5.. MED. ACAD., SOFIA. BULG. KHIG ZDRAVEOPAZ 21 (5). 1978 (RECD. 1979). 440-443. Coden: KHZDA Language: BULGARIAN The embryotoxlc and teratogenic action of v1nyIch1 or 1dc on 40 pregnant white Wlstar rats was examined. The experiments were carried out under the conditions of dally Inhalatory poisoning during gestation at mean dally concentrations of vIny1chI or 1de (6.15 mg/m3 ) . There was a manifested embryotoxlc and teratogenic effect of vInyIch1 or Ide-e1evated total embryonal mortality, lowered fetal wt and Induction of external and Internal anomalies in the development of the fetus. The threshold value of concentrstIon for embryotox Ic I ty and teratogenicity was calculated to be 10 mg/m3. Descriptors: WISTAR RAT TERATOGEN GESTATION Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506); G E NE TICS/CY- TOGENET-ANIMALf*03506): MATHEMATIC BIOL/STATISTIC METH(04500); BIOCHEM STUD-GENERAL( 10060); PATHOLOGY-NECROSIS( 12510); RESPIRATORY SYST-GENL STUD,METHS(16001): REPRODUCT 5YST-PATH0L0GY( 16506) : ROUTES OF IMMUNIZ.INFECT.THERAP(22100 ) ; TOXICDL-GENL/EXP STUDS.METHS(+22501): DEVELOPMNTL B1OL-PATHOL - OGICAL(+25503): DEVELOPMNTL BIOL-EXPER TERATOL(25554 ) B1osys tema tIc Codes: MUR 1 DAE(86375) DIALOG FI1e5: BIOSIS Previews 77-83/Jfin BA7502 ; RRM2402 ( See Flle55) (c. BIOSIS 1982) (Item R&S 138480 _. oaol User 3614 25Jan83 2126 6B045021 DAMAGING EFFECT OF CADMIUM OXIDE DUST TO THE LUNG AND ITS RELATION TO SOLUBILITY OF THE DUST KOSHI K; HOMMA K; SAKABE H NATL. INST. IND. HEALTH. NAGAO 6. TAMA. KAWASAKI, KANAGAWA 213. JPN. INO HEALTH INHEA 16 (2). 1978 (RECD. 1979). 81-90. Coden: Language: ENGLISH The effects of cadmium oxide dusts on the rat lung were studied after exposure of 90 min at a concentration of 19,5 mg/m3 and compared with experiments carried out with calcium carbonate and polyvinyl chloride dusts with different concentrations. Alveolar macrophages, protein and phospholipid In the lung washing fluids of rats and the lung weights were determined 1 h and 21 h after exposure to each dust. Remarkable points In the results were the decrease In number of macrophages and Increase of protein 21 h after exposure to cadmium oxide dusts. The decrease of macrophages yias observed 1 h after exposure to cadmlurti oxide dusts. Cadmium oxide dusts were dissolved easily In water or Tyrodo's solution added with protein or amino acid as In tho case of Cd fume reported previously. Cadmium oxide dusts added In the washing fluid from the lung of rats 21 h after exposuro showed a higher solubility compared with that added In the washing fluid from non-exposod (control) rot lung. Cd which was dissolved from cadmium oxide dusts In albumin or glycine solution showed a strong toxic action on the l.p. macrophages and mouse embryo 3TG fibroblast cells. Decrease of macrophages and increase of protein In the lung washing fluid by exposure to cadmium oxide dusts was apparently evoked by the toxic action of Cd of which solubility was enhanced by the biological medium In the lung containing protein. Descriptors: MOUSE EMBRYO 3T6 FIBROBLAST POLY VINYL CHLORIDE CALCIUM CARBONATE PROTEIN MACROPHAGE DECREASE Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(*02506) : COMPARATIVE BIOCHEM-GENL STUD IE5( 10010); BIOCHEM STUD-GENERAL( 10060): BIOCHEM STUD-PROTEINS,PEPTIDES.AMINO ACD(10064): BIOCHEM STUD-LIPIDS(10066); MINERALS(10069); BIOPHYS-MOLECUL PROP.MAC- R0M0LEC( 10506); CHORDATE BODY REGNS-ARD0MEN( 113 14 ) ; METABOLISM-LIP105( 13006); MINERALS( 130 10); METABOLISM-PROTNS,- PEPTQS.AM ACD$(* 13012); BLOOD/BODY FLDS'LYMPHAT T ISS,RES(* 150- 08); RESPIRATORY 5YST-PHYSIOL.B10CHEM( 16004); RE 5PI RAT ORY SYST-PATH0L0GY(* 16006): INTEGUMENT 5YST-GENL STUDS,METHS(1850- 1): ROUTES OF IMMUNIZ.INFECT,THERAP(22lOO): TOXI COL-GENL/EXP STUDS,METHS(*2 2501); TOXICOL -ENVIRONMNTL.INDUSTR(22506); DEVE- LOPMNTL BIOL-GENL.DESCRIPTIVE(25502) B(osystematIc Codes: MUR I DAE(863 75 ) Language: ENGLISH Maximum concentration levels (MCL). recommended by the National Drinking Water Advisory Council (USA), are more flexible than granular activated C treatment [GAC] for synthetic organic compounds [SOC ] . Considerable data on SOC nro available on which MCL could be based. Tho GAC treatment cannot be Justified by cost analysis for 5 potential carcinogens (bIs(2-ch1oroethy1) ether, CCI4. polychlorinated biphenyls, trIch1oroethy1ene and vinyl chloride]. The Environmental Protection Agency lacks the authority to promulgate the current regulation and should regulate SOC by MCL. Descriptors: ENVIRONMENTAL PROTECTION AGENCY NATIONAL DRINKING WATER ADVISORY COUNCIL USA "BIS-2 CHLOROETHYL ETHER CARBON TETRA CHLORIDE POLY CHLORINATED BI PHENYLS TRI CHLORO ETHYLENE VINYL CHLORIDE CARCINOGEN MAXIMUM CONCENTRATION LEVEL Concept Codes: GENL BI0L-IN5TI TUT,ADMIN,LEG ISLN(00508 ) ; MATHEMATIC BIOL/STATISTIC METH(04500): ECOLOGY-LIMMOLOGY(* 075- 14): BIOCHEM STUD-GENERAL( 10060); MINERALS( 10069 ) ; BlOPHYS-MEMBRANE PHENOMENA( 10508); TOXI COL -ENVIRONMNTL. I NOUST -/ R(* 2250G ) : NEOPLSMS/NCOPL AGNTS-CARCI NOGENS(24007 ); ENVIRON HEALTH-SEWG DISP.SANITAR(+370I4); ENVIRON MEALTM-A IR.WATR.SL POLLNt *37015) 68044291 ORGANICS IN DRINKING WATER MAXIMUM CONTAMINANT LEVELS AS AN ALTERNATIVE TO THE GRANULAR ACTIVATED CAROON TREATMENT REQUIREMENT PENOYGRAFT G W: SCHLEGEL F E: HUSTON M d AM WATER WORKSASSOC J 71 (4). 1979. 174-183. Coden: vJAWWA DIALOG BIOS1S Previews 77-83/Jnn BA7502;RRM2402 ( See File R&S 138481 426 Of 858) User 3614 20Ja 2 127 68042510 HEADSPACE GAS CHROMATOGRAPHIC ANALYSIS OF VINYL CHLORIDE MONOMER IN RAT BLOOD AND TISSUES ZUCCATO E; MARCUCCI F; FANELLI R; MUSSINI E 1ST. RIC. FARMACOL. MARIO NEGRI. VIA ERITREA 62. 20157 MILAN. ITALY. XENOBIOTICA 9 (l). 1979. 27-32. Coden: XENOB Language: ENGLISH A method for measuring [the carcinogen) vinyl chloride monomer (VCM) concentration In rat blood and tissues Is described, using a head-space GLC technique with flame Ionization detector. The method Is sensitive to 5 ng/ml vCM In blood and 30 ng/g In tissues. VCM disposition was determined In rat blood, liver, kidney, brain and lung at different Intervals after administration of 1-10 mg VCM/kg l.v. and 10 mg/kg orally, VCM distributed rapidly In the organism after l.v. administration; It was eliminated rapidly and was no longer detectable at 15 min for the highest dose and at 4 min for the lowest. VCM was absorbed rapidly when given orally and tissue concentrations were measurable for longer than after l.v. treatment. For both routes, VCM concentration In liver and lung decrease faster than In other organs, suggesting that these organs play a role In VCM elimination. Descriptors; LIVER KIDNEY BRAIN LUNG CARCINOGEN GAS LIQUID CHROMATOGRAPHY FLAME IONIZATION DETECTOR Concept Codes: CLIN BIOCHEM-GENL STUD IES(* 10006); COMPARATIVE BIOCHEM-GENL STUD IES( 10010); BIOCHEM METH-GENERAL- (*10050); BIOCHEM STUD-GENERAL ( 10060); BIOPIIYS-GENERAL BIOPMYS TECH(10504); BIOPHYS-MOLECUL PROP.MACROMOLEC(10506); PHYSIOLO GY -COMPARATI VE ( 1 2003 ) ; MOVEMENT(12100); METABOHSM-GENL STUD.METAB PATHW(* 13002); DIGESTIVE SY5T-PHYSIOL,BIOCHEM(* 140- 04); CAROIOVASC SYST-GENL STUDS.METHS(14501); BLOOD/BODY FLDS-BLOOD.LYMPH STUD(* 15002); URIN SYST/EXT SECR-PHYSL.BIOCH- EM(* 15504); RESPIRATORY SYST-PHYSIOL,BIOCHEM(* 16004); DENTAL/- ORAL BIOL-GENL STUD,METHS( 19001): NERVOUS SYST-PHYSIOL,BIOCHE- M(* 20504); . ROUTES OF IMMUNIZ.INFECT,THERAP(22100): TOXICOL-GENL/EXP STUDS,METHS(22501); NEOPLSMS/NEOPL AGNTS-BI- OCHEMI*24006); NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007) B losystemat1c Codes; MURIDAE(B6375) 68041119 STUDIES ON METABOLIC ACTIVATION OF VINYL CHLORIDE IN DROSOPHILA-MELANOGASTER AFTER PRE TREATMENT WITH PHENO BARBITAL AND POLY CHLORINATED BI PHENYLS MAGNUSSON J: HALLSTROM l; RAMEL C ENVIRON. TOXICOL. UNIT. WALLENBERG LAB., UNIV. STOCKII. S-106 91. STOCKHOLM. SWED. CHEM-BIOL INTERACT 24 (3). 1979. 287-298. Coden; CBINA Language: ENGLISH Vinyl chloride Is metabolized by the mixed function oxygenase v/stem (n the liver to reactive mutagenic and carcinogenic metabolites. This metabortc activation was studied In 0. melanogaster by measuring the uptake of 14C from labeled vinyl chloride In different strains [Berlin, Karsnas 60 and Hlkone] and with different pretreatments with phenobarbItaI and polychlorinated biphenyl (PCB) (Clophen A50), well known Inducers of cytochrome P-450. In accordance with previous data on vinyl chloride Induced sex-linked recessive lethals. It was shown that pretreatment with inducers Increased the uptake of labeled compound up to 10 times. There was a marked difference In response between the 5 strains used. The Hlkone strain, known to be Insecticide resistant, had a comparatively high Initial radloact1v|ty from vinyl chloride without any pretreatment. but It was not (or Insignificantly) Inducible with phenobarbIta1 or PCB. Crosses hetwoen Hlkone and an Inducible strain Indicated essentially a dominance for the Hlkone genotype. Tests on Inducible strains showed the same response to phenobarb1ta1 by 2 h old larvae and adult males and females. D1 me thy 1su1fox Ide (DMSO) used as a solvent decreased both the Initial uptake of 1-iC and particularly the Induction by PCB. The use of Tween 80 as an emulsifier did not have such an effect. The Interstrain variation In met abo11c actlvatI on and InduclblIIty has to be taken Into consideration to optimize the use of Drosophila for mutagenicity testing. This variation also opens up new possibilities of analyzing the mixed function oxygenase system biochemically and genetically. Descriptors: KARSNAS 60 BERLIN HIKONE STRAINS LIVER CLOPHEN A - 50 METABOLIC-DRUG MIXED FUNCTION OXYGENASE CYTOCHROME P-450 MUTAGEN CARCINOGEN INSECTICIDE RESISTANCE DI METHYL SULFOXIDE TWEEN 80 CARBON-14 MUTAGENICITY TESTING SEX LINKED RECESSIVE LETHAL Concept Codes: C YT DLOGY/CYTOCIIEM-AN I MAL ( *02506 ) ; C.ENETICS/C- YTOGENET-ANJMAL(*03506); GENET ICS/CYTOGENET-POPULAT GENET(035- 09); GENETICS/CYT OGENET- SEX DIFFERENC(035 IO ) ; RADIATION BIOL-RADTN,ISOTOP TECH(06504); BIOCHEM METH-GENERAL( 10050); BIOCHEM METH-NUCL ACD.PURNS.PYRM(10052); BIOCHEM STUO-GENERAL - (10060): BIOCHEM STUD-NUCL ACD.PURNS.PYRM( 10062 ) : BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACD(10064); BIOCHEM STUD-PORPHYR- NS.BILE PIGM( 10065); BIOCHEM STUD-LIPIDS( 10066); ENZYMES-GEN.- COMPAR STUO.COENZYMS(10802); ENZYMES-METHODS(10804); EN2YMES- -PHYSIOLOGICAL STUD IES(* 10808); PATHOLOGY-COMPARAT IVE( 1 2503 ) : PATHOLOGY-NECROSIS(125IO); METABOLISM-GENL STUD.METAB PATIIW(*13002); METABOLISM-PROTNS.PEPTDS.AM ACDS(* 13012) ; METABOLISM-- NUCL ACD.PURINS,PYRIM(* 13014); DIGESTIVE SYST-PHYSIOL.BIOCHEM- (14004); PHARMACOL-DRUG METAB.METAB ST I MU(* 22003); TOXICOL-GENL/EXP STUDS.METHS(*22501): TOXI COL - ANT I DOTES.PREVE - NT I VE( 22 505 ) : TOX I COL - F.NVI RONMNT L . I NDUSTR ( Q250G ) ; NEOPLSMS/NE - OPL AC.NTS-CARCINOGENSt *24007) ; DEVELOPMNTL BIOL-GENL.OESCR IP1 - IVE(25502): DEVELOPMNTL BIOL-GEN MORPHGENS IS(25500 ) ; ENVIRON HEALTH-AIR.WATR,SL POLLN(37015); PEST CQNTRL GENL/PEST ICS/HER- BICS(54 600); ECONOM ENTOMOL-CHEM PHYS CONTRL(60016 ) ; INVERTfi PHYSIOL- I NSEC1 A-PHYSIOL(64 076); INVERTB PHYSIOL- I NSECT A -PA n 10- L(* G407R) B losystematIc Codes: D IPTERA(753 14 ) ; ABSTRACTS OF ENTOMOLOGY(96000) DIALOG rileS: BIOSIS Previews 77-83/Jan BA7502:RHM2402(Sea F1 Ie55' R&S 138482 m 428 Of 858) User 3614 26Jan83 2128 68039174 INTERACTIONS OF ARTIFICIAL SURFACES THROMBIN AND ANTI THROMBIN III WITH CHUANG H Y K; CROWTHER P E; MOHAMMAD S F; MASON R G DEP. PATHOL., COLL. MED., UN1V. S. FLA.. TAMPA, FLA., USA. THR0ME3 RES 14 (2-3). 1979. 273-282. Language: ENGLISH Coden: THBRA Thrombin adsorption onto Cuprophane surfaces was not saturable at thrombin concentrations of up to 1 mg/ml and gave adsorption Isotherms distinct from those for 4 other proteins: albumin, fibrinogen. Immunoglobulin [Ig] G and ant I thrombin III. Kinetic analyses suggested 2 types of binding sites with thromb1n-Cuprophane apparent Kd of 300 nM and 7igo nM, respectively. Data from the competitive adsorption of thrombin on Cuprophane with albumin and Ig G at low and high thrombin concentrations and the absence of such types of adsorption of thrombin on PVC [polyvinyl chloride] support the concept of the presence of these 2 types of binding sites on Cuprophane. Thrombln-PVC interaction resulted In a Langmuir type adsorption. Ig G showed higher affinity for PVC (Kd = 35 nM) than did the other 4 proteins (Kd = 300-900 nM). A hypothesis that multiple types of binding sites that are specific for certain plasma proteins may exist on various artificial surfaces was proposed. Descriptors: POLY VINYL CHLORIDE ALBUMIN FIBRINOGEN IMMUNO GLOBULIN G Concept Codes: BIOCHEM STUD - GENERAL( 10060); BIOCHEM STUD-PROTEINS,PEPTIDES.AMINO ACD(*100G4); BIOCHEM STUD-CARBOH- YDR.(10068); BIOPHYS-MOLECUL PROP,MACROMOLEC(*10506); BIOPHYS- -BIOENGINEERING( + 10511); ENZYMES-PHYSIOLOGICAL STUD IS(* 10800) ; BLOOD/BODY FLDS"BLOOD,LYMPH STUD(15002); IMMUNOL/IMMUNDCHE- M-GEN METH(*34502) B1osys tema t1c Codes: VERTEBRATA-UNSPECIFI ED(851 SO) meth-lip IDS( 10056): STUD-LIP I OS( 10066) BIOCHEM SfUO-GENERAL( 10060) ; BIOCHEM 68033633 TECHNIQUES FOR SAMPLING THE AIR SEA INTERFACE FOR ESTUARINE AND COASTAL WATERS HAMILTON E I; CLIFTON R J INST. MAR. ENVIRON. RES., 67/69 CITADEL RD. . PLYMOUTH PL 1 3DH, ENGL., UK. LIMNOL OCEANOGR 24 (1). 1979. 188-193. Coden: LIOCA Language: ENGLISH A freezing probe Impacted onto the surface of the sea had a very high efficiency for the removal of most materials present, surface water and any suspended particulate material present to a depth of about 1000 .inu.m. A PVC [polyvinyl chloride] film cast on the sea surface removed solid materials and various organic compounds, such as lipids and hydrocarbons,' floating on the surfaco, but excluded aqueous phases. Descriptors: PARTICULATE LIPID HYDRO CARBON POLY VINYL CHLORIDE FILM Concept Codes: GENERAL FIELD METII0DS(*01008): GENERAL FIELD APPARATUS!*01010): ECOLOGY-OCEANOGRAPHY.LIMNOLOGY!*07510): ECOLOGY-OCEANOGRAPHY(*07512); ECOLOGY-WATR RESRCH,FISHERY BIOL(07517); BIOCHEM METH-GENERAL(*100501: BIOCHpm DIALOG Flle5: BIOSJS Preview? 77-B3/dan BA75' R&S 138483 60032050 SORPTION OF VINYL CHLORIDE BY SELECTED FOOD CONSTITUENTS BIRAN 0: GILBERT S G; GIACIN J R BAIT YIZZHAK, ISR. J FOOD SCI 44 (1). 1979, Language: ENGLISH 56-58. Coden: JFOSA The problem of migration from a packaging material Into packaged food Is treated In the literature using extraction studies from polymeric materials Into simulating solvents such as heptane, oil, water, 3% acetic acid, 507. ethanol, etc. (Flgge. 1972). Such studies provide a good measure for predicting possible migration Into foods. but do not serve as a direct measure for the relative affinity of foods or their components for the migrant (e.g., v1ny1ch1 or Ide monomer, VCM), The approach taken In this study was to establish directly the relative affinities of the basic food constituents for vIny1ch1 oride. Sorption measurements of VCM by 4 basic food constituents, (water, corn oil, casein and sucrose) were conducted. In addition, sorption studies were carried out with oil in water emulsions. For water, oil, dI1/water emulsions and casein. It was found that the partition coefficient values (defined as the equilibrium concentration of VCM sorbed over the equilibrium concentration of VCM In headspace) were fairly constant within the sorbate (VCM) concentrations studied. At 24.degree. C, the partition coefficient values for oil, casein and water were 23.7 .times. 103, 11.7 .times. 103 and 2.1 .times. 103, respectively. Sucrose did not sorb detectable amounts of VCM under the experimental conditions employed. The sorption of VCM by an ol1 -In-water emulsion, representing a multI-component system. follows the same relationship to Initial headspace concentration and temperature as do water and oil. The total amount of VCM sorbed by the emulsion Is not the exact arlthmatlcal sum of potential contributions of Its individual components. Sorption studies showed that the chemical nature of the sorbent (l.e., food constituent), starting sorbate (l.e., VCM) concentrations and temperature are Important factors affecting the extent of vIny1 chi or Ide sorptI on. Descriptors: CORN OIL WATER CASEIN SUCROSE MIGRATION EMULSION Concept Codes: MATHEMATIC BIOL/STATISTIC METH(04500): BI0CHEM METH-GENERAL( 10050); BIOCHEM STUO-GENERAL(M0060 ) ; BIOCHEM STUD-PROTEINS.PEPTIDES,AMINO ACD( 10064): BIOCHEM SruD-LIPIDS( 1O0G6); BIOCHEM STUO-CARBOHYOR.( 10068); EXTERN EFF-TEMPERATURE(10614); MOVEMENT(12100): FOOD TECH-GENL STUDS,METHS(*13502); FOOD TECH-FATS,0ILS( 13514); FOOD TECH-DAIRY PRODUCTS(135 18); FOOD TECH-SUGAR( 13524 ); FOOD TECH-EVALNS PHYS.CHEM PR0PS(* 13530); FOOD TECH-PREP,PROCESSNG- .STORAGE( \ f 3532) : TOXI COL - FOOD,RESIDS,ADD IT.PRESRV(*2 2502): TEMPERATURE-GENL,METHS(23001); PLANT PtIYS1OL-CtlfcM C0N5TITUENT- S(5 1 52 2 ) ; AGRONOMY-GRAIN CR0PS(52504 ) B1osystemat1c Codes: GRAMINEAE(25305 ) (c. BIOSIS 1982) (Item 430 of 850) User 3614 25Jnn83 2 1 29 BlRAN 0; GIACIN J R; HAYAKAWA K; GILBERT S G BAIT YIZZHAK. ISR. J FOOD SCI 44 (1). 1979. 59-61. Coden: JFOSA Language: ENGLISH Sorption of vIny1 chi or 1de (VCM) by dry casein particles was determined as a function of temperature and moisture content. The amount sorbed Increased with a decrease In temperature or reduction In moisture content of the particles. At 30.degree. C, the partition coefficient values (Kp) were 1.05, 0.4 and 0.33 .times. 102-for casein particles of moisture content 3.5. 6.0 and 7.5, weight percent. respectively. The partition coefficient was defined as the equilibrium concentration of VCM sorbed over the sorbate concentretIon In the headspace. The effect of dipole moment of the sorbate on sorption to casein was evaluated by comparing sorptloti of VCM and the analogues, ethylene and vinylIdene chloride. Sorption was Increased with the dipole moment of the sorbate, suggesting the Importance of dipole moment as a sorption Inducing factor. Further supportive evidence for the Importance of dipole moment In sorbate-case 1n Interaction was obtained by a gas chromatographic technique (Inverse phase gas chromatography). Using casein as the stationary phase of a gas chromatographic column, the solutes VCM. ethylene. vinylIdene chloride (VCD) and hexane were pulsed through the column and the peak shapes recorded. Peak shapes Indicated an Interaction between casein and the polar solutes (VCM and VDC) whereas no such Interaction (sorption) was Indicated for the nonpolar solutes, ethylene and hexane. A rate model for VCM sorption by dry casein particles was also developed. Descriptors: TEMPERATURE MOISTURE PARTITION COEFFICIENT DI POLE MOMENT RATE MODEL Concept Codes; COMPARATIVE 8 IOCHEM-GENL STUD IES( 10010 ) ; BIOCHEM METH-GENERAL( 10050); BIOCHEM STUO-GENERAL(* 10060): BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACD(*10064); BIOPHYS-GEN- ERAL STUDIES!10502); BIOPHYS-GENERAL BIOPHYS TECH(10504); BI0PHY5-M0LECUL PROP.MACR0M0LEC(10506): EXTERN EFF-TEMPERATUR- E(* 10614); MOVEMENT( 12100); FOOD TECH-DA IRY PRODUCTS( 1 35 I 8 ) : FOOD TECH-EVALNS PHYS.CHEM PROPS(13530): TOOD TECU-PREP.PROCESSNG.STORAGE(* 13532); FOOD TECH-SYNI1I,SUPPL.EN RICH FOS( 1 3534 ) ; TOX I COL - FOOD.RESIDS.ADD IT.PRESRV( 22502 ) ; TEMPERATURE-GENL.METHS(23001) GB032053 VINYL CHLORIDE SORPTION BY DRY CASEIN PARTICLES MECHANISTIC DIALOgTTIbS: BIOSIS Previews 77-03/Jan R&S 138484 55) (c. BIOSIS 1982) (Item 432 of 058) User 3614 25JanB3 2 no 60029790 MUTAGENIC AND ALKYLATING METABOLITES OF HALO ETMYLENES CHLORO BUTADIENES AND DI CHLORQ BUTENES PRODUCED BY RODENT OR HUMAN LIVER TISSUES EVIDENCE FOR OXIRANE FORMATION BY CYTOCHROME P-4S0 LINKED MICROSOMAL MONO OXYGENASES BARTSCH H; MALAVE1LLE C; BARB IN A: BLANCHE G INT. AGENCY RES. CANCER, LYON CEDEX 2, FR. 150 COURS ALBERT - THOMAS. F-69372 ARCH TOXICOL 41 (4 ), 1979. 249-278. Coden: ARTOO Language: ENGLISH Mutagenicity, expressed as the number of hist revertants per .mu.mol of'test compound per h of exposure, was estimated In 2 strains of S. typhlmurlum In the presence of a postm1tochondr1 a 1 mouse liver supernatant, following exposure to vapors of 1 of a series of halo-olefins. The 1r activity was In the following descending order: 3.4-dIch1orobutene-1 > 1-chiorobutadlene (technical grade) > 2-chiorobutad 1ene > vinyl bromide > vinylIdene chloride > vinyl chloride: marginal mutagenicity was detected In the presence of 1, 1.2-trI chioroethy 1ene and , 1. 1-d1f1uoroethy 1ene, and none with tetrachloroethylene and vinyl acetate. Liver fractions from humans converted vinyl chloride. vinyl bromide, vinylIdene chloride and 2-chIorobutad 1nno Into mutagens. In the plate Incorporation assay. 1,4-d1ch1orobutone-2 was mutagenic per se, and addition of microsomal fractions from human or mouse liver enhanced the mutagenicity; a synthetic putative metabolite, 1,4-dIch1oro-2,3 - epoxybutane was less mutagenic than the parent olefin In strain TA100. Treatment of rats with phenobarb1ta1 or 3-methylcholanthreno caused an up to 2-fold Increase In the liver mlcrosome-mediated mutagenicities of vinyl chloride and vinylIdeno chloride in S. typhlmurlum TA1530; while treatment with pregnono1 one - 16.a 1ph- a,- carbon ItrI 1o, am 1 nonce ton 1trI Io or dlsulflrnm decreased the mutagenic effects. Vinyl chloride, and probably vinyl bromide, wore epoxldtzed by mouse-liver mlcrosomes; volatile alkylating metabolites were trapped by reaction with excess 4-(4-n1trobenzy1)pyrIdIne and analyzed spectrally. 2-Chlorobu- tadlene yielded an alkylating Intermediate, but 1, 1-d1f1uoroethy 1ene, 1, 1-d1 chioroethy 1ene and 1, 1.2-tr Ichlor- oethylene did not. 2-Chloro- and 1-chlorobutodlene, 3,4-dIch1orobutene-1 ,1.4-dIchIorobutene-2 and Its 2,3-epoxy derivative showed alkylating activity with 4-(4-nItrobenzy1)p- yrldlne. which was not related quantitatively to mutagenic activity In S. typhlmurlum TAIOO In the absence of a metabolic activation system. An oxidation of the double bond In certain halo-olefins, which Is dependent on microsomal mono-oxygenases probably Is a common pathway In the formation of biologically reactive Intermediates. The relevance of the metabolites formed during such oxidative processes to the mutagenic, toxic and carcinogenic activities In vivo of some of tho parent compounds Is discussed, Oescrtptors: MOUSE. SALMONELLA-TYPHIMUR UJM TA-100 3 4 01 CHI ORO BUTENE I CHLORO BUTADIENE 2 CHLOKO BUTADIENE VINYL BR0MI0E VINYLI DENE CHLORIDE VINYL CHLORIDE 1 1 2 TRI CHLORO ETHYLENE 1 1 01 FLUORO ETHYLENE TETRA CHLORO ETHYLENE VINYL ACETATE 1 4 DI CHLORO BUTENE 2 1 4 01 CHLORQ-2 3-EPOXY BUTANE 1 1 DI CHLORO ETHYLENE METHYL CHOl.ANTHRENE 4-4 NITROBENZYL PYRIDINF. CARCINOGENS PHENO BARB I IA L PRFGNFNOI AMP CARBONITRI l.E AMINO ACETONITRILE DISULFIRAM METABOLIC-DRUG Concept Codes: COMPARATIVE BIOCHEM-GENL STUOIES( 100 10); BIOCHEM STUO-GENERAL( 10060): BIOCHEM STUD-PROTEI NS,PEPTIDES,A - MINO ACD( 10064): BIOCHEM STUD-PORPHYRNS.BILE PIGM( 10065); BIOCHEM STUD-STEROLS,STEROIDSf10067); BIOPHYS-MOLECUL PROP.MA- CROMOLEC(10506); ENZYMES-GEN.COMPAR STUD.COENZYMS(10802): ENZYMES-PHYSIOLOGICAL STUD IES(*10808); PHYSIOLOGY-COMPARATIVE- (12003); PATHOLOGY -THERAPYf 12512); METABOLISM-GENL STUD,ME T AE3 PATHW(13002); DIGESTIVE SYST-PHYSIOL.BIOCHEM(* 14004 ) ; PHARMACOL-DRUG METAB.METAB ST I MU(* 22003); PHARMACOL - CL INI CAL PHARMACOL(22005); TOXI COL-GENL/EXP STUDS,METHS(*22501); NEOPLSMS/NEOPL AGNTS-BIOCHEM(*24006); NE0PL5MS/NE0PL AGNTS-CA- RCINOGENS( '24007 ) ; BACTERIAL AND VIRAL GENET ICS ( * 3 1500) ; MICROBIOLOG APPARAT,METH5.MED I A(32000): IN VITRO STUDS-CELLUL - R . SUBCELL(32600) B losystemattc Codes: ENTEROBACTERI ACEAE(04810); HOMINI 0 A E ( 8 - 6215): R0DENTIA-UNSPECIFIED(86265); MUR 10AE(8637 5) DIALOG FlleS: BIOSIS Previews R&S 138485 52(See Flle55) (c. BIOSIS 1982) (Item 433 of 858) User 3614 25Jan83 2 13 1 6B029773 ALKYLATION OF RNA BY VINYL BROMIDE METABOLITES IN-VITRO AND IN-VIVO OTTENWAELDER H; LAIB R 0; BOLT H M INST. TOXIKOl., UNIV. TUEB. WILHELMSTR. 56. D-7 4 00 TUEBINGEN-1, W. GER. ARCH TOXICOL 41 (4). 1979. 279-286. Language: ENGLISH Codon: ARTOD The suspected carcinogen [ 1 .2 - 14C]vIny1 bromide was incubated wltb rat liver mlcrosomes, NADPH. and Poly-A acid, Poly-C acid or RNA, respectively. Part of the adenosine moieties In RNA or- In Poly-A acid were alkylated and labeled 1,N6-ethenoadenosIne structures were formed. Part of the cyttdtne moieties were converted Into 3.N4-ethenocytId1ne. A further unidentified cyttdtne alkylation product was observed which was not seen In experiments using (1,2 - 14CJv1ny1 chloride. When rats were exposed to ( 1 .2 - 14C ] vIny1 bromide, radioactive ethenoadenos1ne and ethenocytIdIna were present In hydrolysates of liver RNA. A further alkylation product was observed In the RNA hydrolysates which did not occur In experiments using [14C]v1nyl chloride. Vinyl bromide metabolites apparently alkylate nucleic acids. Although In general In this respect vinyl bromide and vinyl chloride behave similarly, some differences are observed In their alkylation behavior. Descriptors: RAT LIVER MICROSOME VINYL CHLORIDE CARCINOGENS NADPH POLY ADENYLIC-ACID POLY CYTIDYLIC-AC IU TREATMENT.) N-6 ETHENp ADENOSINE 3 N-4 ETHENO CYTID1NE FORMATION CARBON-14 LABELING Concept Codes: CYT0LOGY/CYTOCHEM-ANIMAL(O25O6); RADIATION BIOL-RADTN.ISOTOP TECH(06504); COMPARATIVE BIOCHEM-GENL STU0IES( 100,10) ; B10CHEM STUD-GENERAL ( 10060) ; BIOCHEM STUD-NUCL ACD.PURNS.PYRM(10062); BIOPHYS-MOLECUL PROP.MACROMOLEC(10506); ENZYME5-GEN,COMPAR STUO.COENZYMS(* 10802); METABOLISM-GENL STUD,METAB PATI IW(* 13002): METABOLISM-NUCL ACO.PUR I NS.PYRIM(* 1 - 3014); DIGESTIVE SYST-PHYSIQL.BIOCHEM(* 14004): TOXICOL-GENL/E- XP STUDS,METHS(*22501); NEOPLSMS/NCOPL AGNTS-BIOCHEM(*24006); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(24007); IN VITRO STUDS-CELLIJLR , SUBCELL ( 32600) Blosystomat1c Codes: MURIOAE(0G37S) coll lysis was observed In either of the Isotonic saline systems. This value Increased to 10 mg/ml (10.000 ppm) in the Isotonic buffer system. Efforts were made to correlate the hemolysis and [L929 mouse fibroblast] cell culture toxicity of residual ethylene oxide In 5 medical materials to the toxicity Of pure ethylene oxide. Only materials exhibiting a low order of inherent toxicity showed any correlation. In po1y(vlnyl chloride) tubing containing 1.8 and 2.1 mg ethylene oxlde/g of material. a small amount of toxicity was seen In the cell culture system but toxicity was absent in the hemolysis test. Descriptors: HUMAN MOUSE L-929 FIBROBLAST CELL VINYL CHLORIDE Concept Codes: CYTOLOGY/C YTOCHEM-ANI MAL ( *02506 ) ; CYTOLOC.Y/C- YTOCHEM-HUMAN(*02508); BIOCHEM STUD-GENERAL(10060): MINERALS(- 10069); ANATOMY/HISTOL-SURGERY(1 1 105); BL00D/B00Y FLDS-GEN1. STUDS,METHS(15001): BLOOD/BODY FLDS-BLOOD CELL STUDS(* 1 5004): BLOOD/BODY FLDS-BLO.LYM.RE5 PATH(* 15006); BONE.JNTS.FASC.CONN- /ADIP-GENL( 18001); TOXI COL-GENL/EXP STUDS.METH5(*22501): NEOPLSMS/NEOPL AGNTS-CELL L1NE(24005); TISS CULTURE-APPARAT.M- ETHS.MEDIA(32500): 0 ISINFECTI ON.DISINFECTANTS.STERL(*39500) Blosystemat1c Codes: HOMINIOAE(862 IS ) ; MUR 10AE(86375 ) 68025G77 IN-VITRO EVALUATION OF HEMOLYTIC AND CELL CULTURE TOXICITY POTENTIAL OF RESIDUAL ETHYLENE OXIDE IN SELECTED MEDICAL MATERIALS JONES A B SCH. PIIA1.-M. , UNIV. MI 55. , UNIVERSITY. MISS. 38677, USA. J BIOMED MATER RES 13 (2). 1979. 207-216. Coden: JBMRB Language: ENGLISH The hemolytic potential of pure ethylene oxide (a sterilising agent] In solution was evaluated os a function of Initial ethylene oxide concentration In 3 test systems: diluted whole blood In Isotonic saline. [human] erythrocytes washed and resuspended In Isotonic saline and erythrocytes washed and resuspended In Isotonic phosphate buffer. ConcentratIons of 2 mg/ml (2000 onm) were hrr*s<!nrv hrf------ DIALOG BI0SI5 Prevl R&S 138486 12402 ( See FI leS5) (c. BIOSIS 1982) (Item 435 of 858) User 3614 25Jan83 2 132 68024775 THE COMPARTMENTATION OF ETHYLENE IN DEVELOPING COTYLEDONS OF PHASEOLUS-VULGARIS JERIE P H; SHAARI A R; HALL M A IRRIG. RES. INST.. TATURA, VICTORIA. AUST. PLANTA (BERL) 144 (S). 1979. 503-508. Coden: PLANA Language: ENGLISH Isolated cotyledons of P. vulgaris L. cv. Canadian Wonder accumulated 14C2H4 (0.7-1 .mu.l1-1) from air to give partition coefficients of 1-4, which greatly exceeded the value obtained with steam killed cotyledons (0.05) and with water (0.11). After 14C2H4 treatment 98% of the 14C In the tissue remained as 14C2H4. The labeled ethylene accumulated by cotyledons was released only slowly (1-10% h-1) either In an air stream or Into toluene. Heating to 60.degree. C for 2 h. but not freezing and thawing, caused the Immediate release of 14C2H4 from the tissue.Propylene and vinyl chloride competitively Inhibited the accumulation of 14C2H4. Cotyledons emanated endogenous ethylene at a very low rate but after heating (although not freezing and thawing) 13 nl of ethylene/g fresh mass were released within minutes. Apparently french bean cotyledons hold ethylene In a compartmented form In sufficient amount of account for at least 200 h of emana 11 on. Descriptors: CULTIVAR CANADIAN WONDER HEATING Concept Codes: RADIATION BIOL-RADTN.ISOfOP TECH(0G504); EXTERN EFF-HOT( 10618); MOVEMENT(*12100); TEMPERATURE-GENL,MET - HS(23001); PLANT PHYS1QL-TEMPERATURE(51503); PLANT PHYSIOL-GROWTH,DIFFRENTIAT(*51510): PLANT PHYSIOL-GROWTH SUBSTANCES(*5 15 14); PLANT PHYSIOL-TRANSLOC,ACCUMUL(* 51520); HORTICULT-VEGETABLES(53O0B) B losystemat1c Codes: LEGUMINOSAE(26260) 68023092 MORTALITY EXPERIENCE OF WORKERS IN A VINYL CHLORIDE MONOMER PRODUCT PLANT BUFFLER P A; WOOD S: EIFLER C; SUAREZ L: KILIAN 0 J UNIV. TEX. SCH. PUBLIC HEALTH. P.0. BOX 20186. HOUSTON, TEX. 77025, USA. d OCCUP MED 21 (3). -1979. 195-203. Coden: JOCMA Language: ENGLISH The evidence associating exposure to vinyl chloride with the risk of tumors of various sites. including lung cancer. Is Inconsistent. In 1976 a mortality follow-up study of 464 white males employed In a vinyl chloride monomer (VCM) production plant since 1948 was conducted. Vital status was ascertained for 100% of the cohort. Of the 28 deaths observed. 8 (28.5%) were duo to malignant neoplasms. No angiosarcomas or other liver tumors wore observed. A statistically significant excess war, noted for malignant neoplasms of the respiratory system (P .03). The effect of smoking, duration of oxposuro to VCM, level of exposure and the combined effect of duration and level of exposure were analyzed separately. A 5-yr latency requirement was maintained for all analyses except for the smoking analysis: Levels of exposure to VCM prior to 1971 wore estimated from monitoring data available for the porlorl 1971-1975 by extrapolating the relative levels for Job classifications backwards In time. Smoking histories were not available) for 27.6% of the cohort. When It was assumed that all "unknowns" smoked, a significant excess of respiratory cancer was still observed (P * ,05). When the minimum latency period of 5 yr restricted analysis to the mortality experience after 5 yr from date of initial exposure to VCM for the 314 employees satisfying this criterion, the excess of respiratory cancer was moderate but not significant (P = .06). Both a longer duration and a higher level of exposure during the first 5 yr following the date of Initial exposure were associated with a statistically significant excess of respiratory cancer (P = .02 and .03. respectively). When duration and level of exposure were combined In an overall exposure Index. the results were not significant (P * .07). The discrepancy In the results from the dose - response analyses may be due to the potential error In the estimated levels and the small number of events observed, but the results suggest that a relationship exists between exposure to VCM and respiratory cancer. Descriptors: CARCINOGEN RESPIRATORY CANCER LIVER TUMOR ANGIO SARCOMA SMOKING Concept Codes; MATHEMATIC BIOL/STATISTIC METH(04500); SOCIAL BIOL/HUMAN ECOLOGY(05500); BEHAVIOR BIOL-HUMAN BEHAV I OR(07004) ; BIOCHEM METH-GENERAL( 10050): BIOCHEM STUD-GENERAL( 10060): BIOPHYS-MOLECUL PROP.MACR0M0LEC( 10506); PATHOLOGY-NECROSIS( 1 2 - 510); DIGESTIVE SYST-PATHOLOGY(*14006): CARDIOVASC SYST-BLD VESS PATH0L(* 14508); RESPIRATORY SYST-PATHOLOGY(*16006 ) ; BONE.JNTS.FASC,CONN/AD IP-PATHOL( 18006); PSYCHIATRY-ADDICTION(INC SMOKNG)(* 21004); TOXI COL-GENL/EXP STUDS.METHS(*22501 ); TOXI COL-ENVIRONMNTL.INDUSTR(*22506) : NEO- PLSMS/NEOPL AGNTS-CARCI NOGENS(*24007); PUB HEALTH-AOMINI STR.S- TATI5TICS(37010); ENVIRON HEALTH-OCCUPATNL HEALTH(370 1 3 ) : EPIDEMIOL-ORGANIC DIS,NEOPLASMS(* 37054); PLANT PHYSIOL-CHEM CONSTITUENTS151522) B losystematIc Codes: HOMINIDAE(862 15 ) DIALOG FI 1e5: BIOSIS I R&S 738487 >2;RRM2402(See F I 1055 ) (c. BIOSIS 1982) (Item 437 of 858) User 3614 25Jan83 2 133 68021333 RESISTANCE OF POLYMERIC CABLE COVERINGS TO SUBTERRANEAN TERMITE ATTACK AFTER 8 YEARS OF FIELD TESTING IN THE TROPICS BEAL R Hi BULTMAN J D FOR. SCI. LAB., SOUTH. FOR. EXP. STN., US FOR. SERV., GULFPORT. MISS. 39503, USA. INT BIOOE TER I OR BULL Coden: IBDBA 14 (4 ). 1978 (RECD. 1979). 123-127. Language: ENGLISH Polymers (27) formulated to meet the requ 1 rements for cable sheathing material wore exposed to subterranean termites at 2 field sites. Increasing hardness Improved the resistance of polyvinyl chloride (PVC] plastics considerably, but Increasing surface smoothness. specimen thickness or Incorporating inert fillers had little or no effect. Ethy1ene-propy1ene rubber, chlorinated polyethylene and chlorosulfonated polyethylene were more resistant then PVC polymers of equal hardness. Descriptors: POLY VINYL CHLORIDE PLASTICS ETHYLENE PROPYLENE RUBBER CHLORINATED POLY ETHYLENE CHLORO SULFONATED POLY ETHYLENE Concept Codes: BIOCHEM STUD-GENERAL(10060): PEST CONTRL GENL/PESTICS/HERBICS(*54600): ECONOM ENTOMOL-GENL STUDSf'GOOO- 2); ECONOM ENTOMOL-CHEM PHYS CONTRL(*GOO 16) Blosystemattc Codes: ISOPTERA(75328) 68018482 PREPARATION OF DYNAMIC MIXTURE OF VINYL CHLORIDE AND AIR BY PERMEATION TUBE/ SODA R NATL. INST. IND. HEALTH. NAGAO 6-CHOME TAMA , KAWASAKI. KANAGAWA 213, JPN. INO HEALTH 16 (1). 1978 (RECD. 1979). 29-40. Coden: INHEA Language: ENGLISH A method to construct a permeation tube of vinyl chloride was described. The constructed tube was held In a water Jacket, temperature of which was controlled by cIrcuI a t 1 ng water from a thermo-regu1 a ted water bath, and a clean air diluent flew through the Jacket to prepare a Ir-gas mIx ture stream of known concentration. The concentration of vinyl chloride in the stream was determined gas chromatographIcaI 1y. and a fairly good llnoarlty was observed between the calculated cnacontrntIon and chromatographic peak height. An apparent activation energy of permeation was calculated from temperature dependency of permeation rate. (This Is related to Industrial health monitoring.) Concept .Codes: MATHEMATIC BIOL/STATISTIC METH(04500); ECOLOGY-BIOCLIMATOL.BIOMETEOROL(07 504 ) ; BIOCHEM METH-GENERAL( - 10050): BIOCHEM STUD-GENERAL(*100G0): BI OP! IYS-GENERAL BIOPtlYS TEC!l( 10504): B 1 OPI IYS - B IOENGI NE E R 1 NG( * 105 11); EXTERN EFT-TEMPE RA TURE ( 10614); MOVEMENT( 12100): TOX I COL -ENVIRDNMNTL. INDUST R( * - 22506); TEMPERATURE-GENL,METHS(2300 I ); ENVIRON I IEALTH-OCCURAT- NL HEALTH!*37013); ENVIRON HEALTH-AlR,WATR,SL P0LLN(37015) 68016571 POTENTIAL HAIOGENATED INDUSTRIAL CARCINOGENIC AND MUTAGENIC CHEMICALS PART 1 HALOGENATED UNSATURATED HYDRO CARBONS FISHBEIN L NATL. CENT. TOXICOL. RES., JEFFERSON, ARKANSAS 72079. USA. SCI TOTAL ENVIRON II (2). 1979. 111-162. Coden: STEVA Language: ENGLISH The halogenated aliphatic hydrocarbons represent one of the most Important categories of Industrial chemicals from a consideration of use categories. production volume, environmental and toxicological considerations, and hence most Importantly, potential population risk. The major unsatumtod hydrocarbons reviewed, primarily In terms of their synthesis, utility, stability. distribution and levels of exposure as well as their reactivity, care 1 nogen 1cIty. mutagenicity and metabolism. Include: vinyl chloride, vinylIdene chloride, tr I ch1oroethy1ene, perch 1oroethy 1ene, chloroprene, trans-1.4-- dIch1 orobutene, hexnchlorobutad Iene and ally) chloride. Descriptors: VINYL CHLORIDE VINYLIOENE CHLORIDE TRI CHLORO ETHYLENE PER CHLORO ETHYLENE CHLOROPRENE TRANS-1 4 DI CHLORO BUTENE HEXA CHLORO BUTADIENE ALLYL CHLORIDE CARCINOGENS Concept Codes: BIOCHEM METH-GENERAL( 10050) : BIOCHEM METH-MINERALS( 10059); BIOCHEM STUD-GENERAL( 10060); MINERALS! 1 - 0069); B 10PHYS-MOLECUL PROP,MACROMOLEC( 10506 ) ; TOXICOL-ENVIRO- NMNTL.INOUSTR!*22506); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(*2400- 7): ENVIRON HEALTH-OCCUPATNL HEALTH(* 37013); ENVIRON IIEALTH-AIR.WATR.SL POLLN{37015) Blosystemat1c Codes: AN IMALIA-UNSPECIFI ED(33000) DIALOG FlleS: BIOS1 -\38488 7502;RRM2402(See F 1 1e55) (c. BIOSIS 1982) (Item 440 of 858) User 3614 25jan83 2 134 60015332 THE MUTAGENIC EFFECT OF 1 2 DI CHLORO ETHANE ON SALMONELLA-TYPHIMURIUM PART 2 ACTIVATION BY THE ISOLATED PERFUSED RAT LIVER RANNUG U; BE IJE B DIV. TOXICOL. STOCKHOLM. SWED. GENET.. UNIV. WALLENBERG LAB.. STOCKH.. CHEM-BIOL INTERACT Language: ENGLISH 24 (3). 1979. 265*286. Codon: CBINA S. typhImurlum strlans TA 1530 and TA 1535 were combined with Isolated perfused rat liver. Samples of perfusate and bile produced were tested for mutagenicity after treatment with 1.2-dlchloroethane (DCE ) , 1.2-dIbromoetbane (DBE ) or 2-chloroethanol. Tbe results are In good agreement with previous experiments which Indicated that both DCE and DBE are activated through conjugation with glutathione (GSH). Most GSM conjugates are normally excreted In bile. Tollowing liver perfusion the bile was highly mutagenic after DCE and DBE treatments, while 2-ch1oroethario1 did not have this effect. The highest mutagenic effect'was seen 15-30 min after the addition of DCE or DBE. The production of mutagenic bile also occurred In mice treated In vivo with DCE. One possible metabolic endproduct of a GSH conjugate Is the corresponding mercapturlc acid. Thus synthetic N-acety1 -S-(2-chioroethy 1)-L-cystelne was tested on TA 1535 and was as mutagenic as S-(2-ch1oroethy 1)-L-cysteIne In the concentration range 0.2-0.6 .mu.mol/plate. Differences and similarities In the metabolIsm of DCE and vinyl chloride are discussed on the basis of these results. Human applicability Is Implied. Descriptors: TA-1530 TA-1535 STRAINS MOUSE HUMAN BILE VINYL CHLORIDE 1 2 DI BROMO ETHANE 2 CHLORO ETHANOL N ACETYL-5-2-CHLOROETHYL-L CYSTEINE 5-2 ClILOROETHYL-L CYSTEINE GLUTATHIONE CONJUGATION EXCRETION METABOLISM Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(+02506); GENETICS/C- YTOGENET-ANIMALC *03506): GENET ICS/CY TOGENE T-HUMAN(*03500): BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-NUCL ACD,PURNS,PYRM- (10062): BIOCHEM STUD-PROTE INS . PEPT IDES , AMINO ACDM00G4); ENZYMES-PHYSIOLOGICAL STUDIES(* 10800): PATHOLOGY-COMPARAT I VE ( - 12503); METABOLISM-GENL STUD,METAB PATHW(* 13002); METABOLISM-- NUCL ACD,PURINS,PYRIM(* 13014); DIGESTIVE 5YST-GENL STUDS.METHS(14001); DIGESTIVE SYST-PHYSIOL.BIOCHEM(* 14004 ) ; BLOOD/BODY FLDS-OTHER BODY FLDS(15010); URIN SYST/EXT SECR-PHYSL,BIOCHEM(15504); TOXI COL-GENL/EXP STUDS.MTHS(*2250- 1); BACTERIAL AND VIRAL GENET ICS(31500); MICROBIOLOG APPARAT.METHS.MED I A(32000); TISS CULTURE-APPARAT,METHS,MEDlA(- 32500); IN VITRO STUDS-CELLULR.SUBCELL(32600) 6iosystematlc Codes: ENTEROBACTERI ACEAE(04810): HOMINI DA E (8 6215): MURIDAE(86375) Language: ENGLISH I ho possible contamination of dr 1nk1ng water from water pipe materials was Investigated. Polyurethane pipes leached chlorobenzene and ar.omatlc compounds. Homogenous polyvinylchloride pipe leached low concentrations of 3 contam I nants. Cast Fe pipes with asphalt or cement linings did not affect water quality. Descriptors: CHLORO BENZENE AROMATICS POLY URETHANE POLY VINYL CHLORIDE Concept Codes: ECOLOGY-LIMNOLOGY(*07514); E COL OGY-WA T R RESRCH.FISHERY BI0L(07517 ); BIOCHEM STUD-GENERAL( 10060); MINERALS! 10069): BIOPHYS-BIOENGINEERING( 105 1 1 ) : TOXICOL-ENVJR- ONMtlTL . 1NDUSTR! *22506) ; ENVIRON HEALTH- SEWG D I SP , S AN I T A R ( 3 70- 14); ENVIRON HEALTH-AIR,WATR.SL POLLN(*37015) 68012012 THE LEACHING OF VOLATILE ORGANIC COMPOUNDS FROM DIFFERENT TYPES OF WATER PIPES EKl.UND G; JOSFFSSON B; RODS C DEP, ANAL. CHEM., CHALMERS UNIV. TECHNOL., PACK. S-402 20 GOTEBORG. SWED. VATTEN 34 (3). 1978. 207-208. Cnrlrkn4 ` DIALOG F11e5 : B R&S 138489 -i BA7502;RRM2402(See Flle55) (c. BIOSIS 1982) (Item 442 of 858) User 3614 25jnn83 2 135 6801I 127 CHANGES IN CORTICO STEROID SYNTHESIS OF THE HUMAN ADRENAL CORTEX IN-VITRO INDUCED BY TREATMENT WITH 0 P DDD FOR CUSHINGS SYNDROME EVIDENCE FOR THE SITES OF ACTION OF THE DRUG TOUITOU Y; BOGDAN A; LUTON <J-P BIOCHEM. DEP., FAC. MED. PITIE-SALPETRI ERE, 91 BLVD. DE L' HOPITAL, 75634 PARIS, FR. d STEROID BIOCHEM Coden: JSTBB Language: ENGLISH 9 (12). 1978 (RECD. 1979). 1217-1224. The In vitro synthesis of cortisol, cortisone, corticosterone, 18-hydroxycortIcosterone, aldosterone and 11-dehydrocortIcosterone was studied In human adrenals removed from patients with Cushing's syndrome (adrenal adenomas, hyperplasias or carcinoma) treated or not with o,p'-DDD. A very significant fall occurred In the synthesis of cortisol (precursor: 1 I-deoxycor11 sol), cortIcosterone (precursor: 11-dnoxycortIcosterone), 18-hydroxycortI costerone and aldoste rone (precursors: 11-deoxycor11 costerone and cortI costerone) In the adrenals resected from patients treated with o.p'-DDD. when compared with adrenals from untreated patients. In 1 patient with Cushing's syndrome, cortI costeroIdogenes I s was studied on both adrenals, Tho 1st adrenal was removed after treatment with o,p'-DDD for a month (treated adrenal); the 2nd was removed 4 mo. later when the patient relapsed. No medical treatment was given during this period (control adrenal). Steroids synthesis (cortisol, corticosterone, 18-hydroxycortI- costerone, aldosterone) was much lower (40-60%) In treated adrenal as compared to control adrenal. These results clearly establish the Inhibitory effect of o.p'-DDD on 1 1 -hydroxy 1ase and 18-hydroxylase activities In human adrenals of treated subjects. In contrast, addition of o.p'-DDD (10-2 M). o.p'-DDE (10-2 M). p-,p'-DDMU [ 2,2-b 1 s (p-chl oropheny 1 ) - 2-ch 1 oroe t hy 1 ene ) (10-2 M) and p.p'-DOOH [2.2-b I s(p-ch1oropheny1ethano1)] (2.1 .times. 10-3 M) to Incubation media had no effect on steroid synthes1s. Descriptors: 11 DEHYDRO CORTICO STERONE ALDO STERONE 10 HYDROXY CORTICO STERONE CORTISONE CORTICO STERONE CORTISOL Concept Codes: CLIN BIOCHEM-GENL STUDIES(*1000G): BIOCHEM STUD-STEROLS,STEROIDS! 10067) ENZYMOS-METHOOSf * 10804); ANATOM- Y/H1ST0L-SURGERY( 11105); PATHOLOGY - THERAPY( 12512); METABOLISM- -5TER0LS,STER0IDS(13008); METABOLISM-METABOLIC DI SOROERS(* 13- 020); ENDOCRINE SYST-ADRENALS(17004 ) ; PIIARMACQL-DRUG METAB.METAB ST I MU(* 22003); PIIARMACOL-CLINICAL PI IARMACOL(22005) ; PIIARMACOL-ENDOCRINE SY5T(*22016); NEOPLSMS/NEOPL AGNT S-BIOCI IEM(*24006); NEOPLSMS/NEOPL AGNTS-Tl IEHAP,AGNI(*2400- 8); TISS CULTURE-APPARAT,METIIS.MEDIA(32500); IN VITRO STUDS-CELLULR.SUBCELL(32600) Blosystemat1c Codes: HOMINIDAE(8G2 15) 60010176 ANGIO SARCOMA OF THE SPLEEN A REPORT OF 2 CASES AND REVIEW OF THE LITERATURE CHEN K T K; BOLLES d C: GILBERT E F DEP. PATHOL., FRESNO COMMUNITY IIOSP.. P.0, BOX 1232. FRESNO. CALIF. 937 16 VISA ARCH PATHOL LAB MED APLMA 103 (3). 1979. V22-124. Coden: Language: ENGLISH UI trostruetura1 study of 1 of 2 cases of splenic angiosarcoma established the blood vessel origin of th i s tumor. Previously reported cases (53) were reviewed, None of tho 55 patients had a history of exposure to thorium dI ox I do. vinyl chloride or As. which are known to be associated with hepatic angiosarcoma and other tumors. A comparison of the splenic and hepatic angiosarcomas showed that tumors not associated with exogenous material frequently Involve the spleen and liver simultaneously. Tumors associated with thorium dioxide, vinyl chloride. or As commonly Involve the liver with sparing of the spleen. Descriptors: HUMAN LIVER INVOLVEMENT THORIUM DI OXIDE VINYL CHLORIDE ARSENIC CARCINOGENS Concept Codes: RADIATION BIOL-RADTN EFF.PROTECT(*06506): BIOCHEM STUD-GENERAL(10060); MINERALS!10069); ANATOMY/HISTOL-- MICRO.ULTRAMICRSC( 11 10B); PATHOLOGY-COMPARATIVEt 12503) : DIGES TIVE SY5T-PATH0L0C.Y( 14006) ; CAROIOVASC SYST -BLD VESS PATHOLf14508); BLOOD/BODY FLDS-LYMPHAT TISS.RES(* 15008); BONE .JNTS,FASC,CONN/AD IP-PATHOL( 18006 ) ; PHARMACOL - C.E NE R A L STU DI ES(22002); TOXICOL-GENL/EXP STUDS,METHS(* 22501 ) ; TOXICOL-P- IIARMACOLOGI C A1. ( *22504 ) ; TOXI COL - ENVI RONMNT L , INDUSTR( 2250G ) ; NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(*24007); NEOPLSMS/NEOPL AGNT S-BLOOD,RE S(*24010) B losystemat Ic Codes: FIOMINIDAE ( 862 15 ) 68008217 PENETRATION OF DIFFERENT PACKING MATERIALS BY SOME STORED PRODUCT INSECTS KHARE B P; SHUKLA R P DEP. ENTOMOL., COLL. AGRIC., GOVINO BALLABH PANT UNIV. AGRIC. TF.CIINOL,, PANTNAGAR. NAINITAL 263 145, U.P.. INDIA. INDIAN J AGRIC SCI 49 (2). 1979. 116-117. Codon; IJASA Language: ENGLISH Sltophtlus oryiao (Linn.) and Rhyioportha domlnlca (rabr.) easily penotrate cloth bags. According to their resistance to penetration by both Insocts, pncktng materials are arranged In the order; polyvinyl chloride > poI yethy1ene- 1 I ned gunny bags > po1 ye thy 1 one > laminated polyothylone > hessian cloth > muslin cloth > cotton cloth. Descriptors: S1 TOPHILUS-ORYZAE RllYZOPERTHA-DOM INICA CLOTH POlY VINYL CHLORIDE POLY ETHYLENE LINED GUNNY BAGS MUSLIN COTTON Concept Codes: BIOCHEM STUD-GENERAL(10060): FOOD TECH-GENL STUDS,METHS( * 13502); FOOD TECU- PREP.PROCESSNG,STORAGE(* 13532 ) ; ECONOM ENTOMOL-S1 ORED PRODUCTS(*60008); ECONOM ENIOMOL-CHEM PHYS C0N1RI(*60016) BlosystematIc Codes; MALVACEAE(26330): COLEOPTERA(75304) DIALOG Flle5: BIOSIS ProvleW3 77-03/Jnn ha RRM2402 ( See rilo55) (c, RI0S1S 1902 ) (Item 44S of 850) User 3614 2 5 j 2 136 R&S 138490 68006117 VINYL CHLORIDE DISEASE IN BULGARIA NOSKO M; PERNOV K; SPASOVSKI M RES. INST. HYG. OCCUP. OIS,. ACAD. MED., SOFIA. BULG. KHIG ZDRAVEOPAZ Codon: KIIZDA 20 (5). 1977 (RECO. 1978). 409-412. Language: BULGARIAN The concentratIons of vtnylchlorIda were followed from the beginning of v1ny1ch1 or 1de production till now during Its synthesis and polymerization. In 1965 they were 110 mg/m3 but since 1970 they were In the ranges of 12-240 mg/m3 (the threshold value Is 30 mg/m3). Workers (137) were examined for neurologic status, changes In hemopoiesis and protein and enzymic function of liver. Ten cases of v1ny1ch1 or 1de disease and 19 with single syndromes were discovered. The sick persons mainly worked at the polymerization of v I ny1ch1 or I do at the repair workshop with a length of service of 3-11 yr. Vegetative polyneuropathy and Increased activity of .gamma,-g1utamyltranspeptidase were the leading signs. There were acrp-osteo1ys1s and thrombocytopenia In some patients. Medical prophylactic measures In respect to a 6 h working day. additional food without pay. preliminary and periodic examinations of the workers and suitable labor establishment of the same patients were suggested. An experiment is carried out to correct the threshold value concentration. OescrIptors: HUMAN NEUROPATHY ACRO THROMROCY T OPENI A GAMMA GLUTAMYL TRANS PEPTIDASE OSTEOLYSIS Concept Codes: CYT0L0GY/CYT0CHEM-HUMAN(02508): SOCIAL BIOL/HUMAN ECOLOGY(05500); BIQCHEM STUD-GENERAL(10060); BIOCHCM STUD-PROTEINS.PEPTIDES,AMINO ACD(I00G4); ENZYMES-PHYS- 10L0GICAL STUDIES(* 10808); PATHOLOGY-DIAGNOSTIC( 12504 ) ; NUTRITION-GENL.NUTR STATUS.METHS(13202); DIGESTIVE SYST-PHYSI- OL.BIOCHEMf14004): BLCQD/BODY FLOS-BLOOO CELL STUDS(*15004); BLOOD/BODY FLDS-BLD.LYM.RES PATH(* 15006); BONE.JNTS.FASC.CONN- /ADIP-PATHOL(* 18006): NERVOUS SYST-PATHOLOGY(20506); TOXICOL- - ANTIDOTES .PREVENTIVE( *22505.); TOXICOL-ENVIRGNMNTL,INDUSTR(*22506); ENVIRON HCALTH-OCCUPATNL HEALTHt*37013) ; ENVIRON HEALTH-AIR.WATR.SL P0LLN(37015) B(osystemat1c Codes: H0M1NIDAE(862 15) of the modulation techniques used. the observed signal as a fund Ion of electric field Is the 1st derivative of the absorption line profile, and the peak-to*peak Intensity of the derivative Is the measured analytical signal. The analytical curve Is a straight line over several orders of magnitude in concontratI on. In all cases. ppm or sub-ppm concert tratIons of the gases In air and/or N are measured using a C02 laser, a discussion of Interferences and selectivity of the technique are Included. Descriptors: VINYL CHLORIDE VINYLIDENE CHLORIDE ACRYLONITRILE METHANOL STARK EFFECT Concept Codes: RADIATION BIOL-RADTN.TSOTOP TECH('06504); ECOLQGY-BIOCLIMATOL,BIOMETEOROL(*07504); BIOCHEM-GASES(10012): BIOCHEM METH-GENERAL(* 10050); BIOCHEM STUD-GENERAL( 10060): B IOPHYS-GENERAL BIOPHYS TECH( 10504); BIOPHYS-MOLECUL PROP,MACROM0LEC( 10506); EXTERN EFF-LI GUT,0ARKNESS( 10604 ) : EXTERN EFF-ELECTR.MAGNET.GRAVITY( 10610); TOXICOL -ENVIROMMNTL. - I NOUS TR(* 2 2 506); ENVIRON HEALTH-A 1R.WATR.SL P0LLN( * 37015) 68005568 AN APPLICATION OF IR LASERS TO THE SELECTIVE DETECTION OF TRACE ORGANIC GASES SWEGER 0 M; TRAVIS d C NATL. BUR. STAND.. WASHINGTON. D.C. 20234, USA. APPL SPECTROSC 33 (1). 1979. 46-51. Coden: APSPA Language: ENGLISH For molecules possessing a permanent electric dipole moment the Stark effect may be used to perturb the molecular energy levels and to tune some absorption lines Into coincidence with fixed frequency lasers. The same perturbation may modulate the absorption and allow the use of sensitive AC detection techniques. . Quantitative results for 4 organic gases of Industrlal. Importance [vinyl chloride. vinyl I dene chloride, aery 1 on Itr11e and methanol) are presented. All have overlapping absorption bands In the C02 laser region. Because DIALOG FIle5: B 1 BA7502;RRM2402(See F11e55) (c. BJOSIS 1982) (Item 447 of 858) User 3614 2SJan83 2 137 R&S 138491 60002762 LACK OF MUTAGENICITY OF 2 POSSIBLE METABOLITES OF HALOTHANE WASKELl L DEP. BIOCHEM. , UNIV. CALIF., BERKELEY, CALIF. 97-120, USA. ANESTHESIOLOGY 50 (1). 1979. 9-12. Codon: ANESA Language: ENGLISH 1,1-D1f1uoro-2-bromo-2-chloroethy1ene, a probable metabolite of halothane, was purified by preparative gas chromatography and tested for mutagenicity In the Salmonella/mammalian liver system developed by Ames et al, 1,1,1-Tr1f1uoro-2*chloroethane which was Isolated from the breath of rabbits anesthetized with halothane also was tested for mutagenicity In a similar manner. Both compounds were nonmutngenlc In this bacteria system. Although no study has yet demonstrated that halothane or any of its metabolites Is genetically active. unnecessary [human] occupational exposure to the drug should be avoided due to the possibility that future .studios could reveal adverse ef reels secondary to halothane. Descriptors: SALMONELLA MAMMALIAN LIVER MICROSOME HUMAN RABBIT 1 1 1 TRI FLU0R0-2-CHL0R0 ETHANE I 1 01 FLUORO-2-BROMO-2-CHLORO ETHYLENE GENERAL ' ANESTHETIC BREATH OCCUPATIONAL HAZARD GAS CHROMATOGRAPHY Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(*02506); GENETICS/C- YTOGENET-ANIMALf*03506); GENETICS/CYTOGENE T-HUMAN(*03508); BIOCHEM-GASES(10012); BIOCHEM METH-GENERAL(10050): BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-NUCL ACD,PURN5,PYRM(10062); BIOCHEM STUD-PROTEINS,PEPTIOES,AMINO ACD(1006-1): BIOPHYS-GENE- RAL BIOPHYS TECH( 1050-1 ); ENZYMES-PHYSIOLOGICAL STUD IE$(*10808) ; M0VEMENT(12100): METABOLISM-GENL STUD,METAB PATHW( 13002); METABOLI5M-NUCL ACD.PUR I NS.PYRIM(13014): DIGESTIVE SYST-GENL STUDS,METHS(14001): DIGESTIVE SYST-PHYSIOL.BIOCHEMf* 14004): RESPIRATORY SYST - PHYSIOL , BIDCHEM ( 1 600-1) ; PHARMACOL-DRUG METAB.METAB'STIMU(22003); PHARMACOL-CL INICAL PHARMACOL(22005 ) ; PHARMACOL-NEUROPHARMACOLOGY(2202A); TOX1 COL-GENL/EXP STUDS,ME - THS(22501); TOXI COL-PHARMACOLOGI CAL(*22504): BACTERIAL AND VIRAL GENETICSOI500) ; MICROBIOLOG APP ARAT , METHS . MEOIA ( 32000); ENVIRON HEALTH-OCCUPATNL HEALTH(*37013) BlosystematIc Codes: ENTEROBACTERIACEAE(04010); MAMMALI A-UN- SPECIFIED AND EXTINCT(85700); LEPORIDAE(86040); HOMINIDAE(862 15) procedures and sampling techniques are discussed. covering automatic operation In the field and discontinuous control by analyses performed In the laboratory. The efficiency of the overall procedure is Illustrated by the results obtained during 2 pollution measuring campaigns. one performed In the neighborhood of a vinyl chloride plant and the other In an area with an Intensive paint Industry. Descriptors: HYDRO CARBON CHLORINATED HYDRO CARBON AROMATICS Concept Codes: ECOLOGY-81OCLIMATOL,BIOMETEOROL(*07504 ) : BIOCHEM-GASES(10012); BIOCHEM METH-GENERAL(10050): BIOCHEM STUD-GENERAL(10060); BIOPHYS-GENERAL BIOPHYS TECM(10504); MOVEMENT! 12100); TOXI COL-ENVIRONMNTL. IN0U5TR(* 22506) ; ENVIRON HEALTH-AIR.WATR.SL POLLN(*37015) 67074383 IN-VIVO TRAPPING OF A VINYL CHLORIDE METABOLITE BY MEANS OF 3 4 DI CHLORO BENZENETHIOL MUELLER G; NORPOTH K; OWZARSKI W INST. STAUBLUNGENFORSCH. ARBEITSMEO.. WESTFAEL. WILHELMS-UNIV.. WESTRING 10. 0-4400 MUENSTER. W. GER. INT ARCH OCCUP ENVIRON HEALTH 42 (2). 1978 (RECD. 1979). 137- 139. Coden: 1 ADI ID Language: ENGLISH The successful trapping of a vinyl chloride metabolite and a metabolite of 2.2`dI chirorod1ethy 1ether In a carcinogen detection test is reported. The reaction products are excreted as S-2 (3.4 d lehloroth lopheny1) acetic acid In the urine of rats. This was confirmed by GC-MS (gas chromatography-mass spectrophotometry] measurements. Descriptors: RAT URINARY EXCRETION CARCINOGEN GAS CHROMATOGRAPHY MASS SPECTROPHOTOMETRY Concept Codes: BIOCHEM METH-GENERAL( 10050): BIOCHEM STUD-GENERAL( 100G0): BIOPHYS-GENERAL BIOPHYS TECH( 10504); MOVEMENT( I 2 100); METABOLISM-GENL STUD,ME T AB PATHW(* 13002 ) ; UR 1N SYST/EXT SECR-PHYSL,BIOCMEM( 15504); TOXI COL-GENL/EXP STUDS.METHS(*22501): NEOPLSMS/NEOPL AGNTS-BlOCHEMf * 24006); NEOPLSMS/NEOPL AGNTS-CARC INUGEN5(*24007) BlosystematIc Codes: MUR I DAE(86375 ) 67076486 TRACING ORGANIC GASEOUS POLLUTANTS IN THE ATMOSPHERE THE GAS CHROMATOGRAPHIC SURVEY OF VINYL CHLORIDE AND PAINT INDUSTRY RYMEN T A A CHEM. DEP., STUD IECENT, KERNENERG./CENT. ETUD. ENERG, NUCL.. MOL, BELG. . INT J ENVIRON ANAL CHEM 6 (I). 1979. 1-24. Codon: IJEAA Language: ENGLISH Low MW hydrocarbons, chlorinated hydrocarbons and aromatics are 3 groups of volatile organic chemicals that are widely used in industry and constitute a potential danger for the environment. Selective tracing of these pollutants In ambient air was performed with the aid of gas chromatography and flame Ionization or electron capture detection, whichever yielded R&S 138492 dialog F 1 1e5: BIOSIS Previews 77-83/dan BA7502:RRM2402(See Flle55) (c. BIOSIS 1982) (Item 450 of 858) User 3614 25Jan83 2 138 67074352 GAS CHROMATOGRAPHIC STUDIES OF VINYL CHLORIDE IN AIR BY CATALYTIC HYDROGENATION TO ETHYL CHLORIDE HENDIFAR A R; T1RGAN M R CHEM. DEP., NATL. UNIV. IRAN. EVIN, TEHERAN, IRAN. J CHROMATOGR 161. 1978. 119-126. Coden: JOCRA Language: ENGLISH To investigate the amount of the carcinogen vinyl chloride In air, the hydrogenation of vinyl chloride to ehtyl chloride Is used. This method of determination Is preferable to the other methods because: (a) it proves that only vinyl chloride goes through hydrogenation by Its displacement to the ethyl chloride peak In the chromatogram; (b) the actual amount of vinyl chloride can be obtained In the case of superimposed or Interfering peaks (e.g., various gases contained In air samples). either by calculating the ethy1 ch1 or Ide peak area or by the reduction of the peak area In the region of the same retention time as the vinyl chloride peak In the related chromatogram. Various kinds of catalysts for hydrogenation purposes at temperatures ranging from -20 to 250.degree. have been used. Among the catalysts used; Pd gives the best results at low temperature. Descriptors: CARCINOGEN PALLADIUM Concept Codes; MATHEMATIC BIOL/STATISTIC METH(045OO); BIOCHEM-GASES(10012); BIOCHEM METH-GENERAL(10050); BIOCHEM STUD - GENERAL(*I00G0): MINERALS(100G9); BIOPHYS-GENERAL BIOPHYS TECH(10504); EXTERN EFF-C0LD(1061G); EXTERN EFF-H0T( 10618); MOVEMENT(121O0): TOXICOL -ENV1RONMNTL.INDUSTR(*22506); TEMPERA TURE-GENL . METHS ( 2300 1 ) : NE0PLSM5/NE0PL AGNTS-CARCI NOGENS(*240- 07); ENVIRON HEALTH-AIR.WATR.SL P0LLN(*37015) Blosystemat1c Codes: CHORDATA-UNSPECIFIED(B5000) mechanisms affecting the fate of organic pollutants. fate of carcinogens, human exposure and Interactions of hum 1 c substances with herbicides. Tables, references, diagrams and a subject Index supplement the text and Individual papers by contributing authors are Indexed In BIORESEARCH INDEX. Descriptors: BOOK FISH HUMAN SULFUR 01 OXIDE CHLORO ETHYLENE BORON HYDRIDE PHOSPHORUS HYDRIDE RADIO NUCLIDE PUTHALIC - AC I D TOXAPHENE CARCINOGEN HUMIC SUBSTANCE HERBICIDE Concept Codes: GENL BIOL-SYMPOSI A,PROCONGS,REVW(* 00520): RADIATION BIOL-GENERAL STUD IES(06502); ECOLOGY-BI0CLIMATOL .BI - 0METE0R0L(*07504); ECOLOGY-AN1MAL(0750B); ECOLOGY-OCEANOGRAPH- Y . LIMNOLOGY ( *075 10) ; ECOLOGY - L I MN0L0C.Y ( *075 14); B IOCHEM-GASE S- (10012); BIOCHEM STUD-GENERAL(10060); EXTERN EFF-LIGHT.DARKNE- SS( 10604); BONE,JNTS.FASC.CONN/AD IP-PHY,BCH( 18004 ) ; TOXICOL-E- NVIRONMNTL.INDUSTRt*22506); NE0PLSM5/NE0PL AGNTS-CARCI NOGENS(- 24007); ENVIRON HEALTH-A IR.WATR.SL POLLNf *37015) ; ENVIRON HEALTH-RADIATION |IEALTH(*370 17); PLANT PHYSIOL-GROWTH SUBSTANCES!51514); AGRONOMY-WE EDS AND WEED CONTROL(525 I 0 ) ; PEST CONTRL GENL/PESTICS/HERBICS(54600) B losystomat1c Codes: PISCES-UNSPECIFI ED(85200 ) ; HOMINI DA E(8 62 15) 67073223 ADVANCES IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY VOL 8 FATE OF POLLUTANTS IN THE AIR AND WATER ENVIRONMENTS PART 2 CHEMICAL AND BIOLOGICAL FATE OF POLLUTANTS IN THE ENVIRONMENT SYMPOSIUM AT THE 165TH NATIONAL AMERICAN CHEMICAL SOCIETY MEETING IN THE ENVIRONMENTAL CHEMISTRY DIVISION PHILADELPHIA PENNSYLVANIA USA APRIL 1975 SUFFET I H AOV ENVIRON SCI TECHNOL 1977 (RECD. 1970). 442. Coden: AESTC Language: ENGLISH The 2nd part of the treatise describes the fate of pollutants In air and water environments from local and global perspectives. The 1st section considers the chemical Tate of pollutants in the atmosphere and Includes papers on the formation and removal of S02 and oxidants, aerosol formation In phoIochemIcn1 systems, ch I oroe thy 1 one oxidation and the fate of B and P hydrides. This Is followed by a section concerned with discussions on the biological fate and transformation of pollutants, radionuclides In aquatic environments, dynamics of phthallc ncld esters and tho effects of toxapheno on bone .development and growth of fish. The remaining section Is devoted to the chemical no 1 * ' + T' * * ** *,r -H * ^ f ,, s,. P ' ` ' ' > - - ' fate of R&S 138493 DIALOG FI1e5: BIOSIS Prev i ews. 77 - 83/Jan ba , n,,,.,*. .See FHe55) (C. BIOSIS 1982) (Item 452 of 858) User 3614 25janB3 2139 67073194 SOME APPLICATIONS OF NONDISPERSIVE X-RAY FLUORESCENCE TO FORENSIC INVESTIGATIONS CROPP P L; HURST F; WALLACE G; WHITEHEAD N E; MCCALLUM G J CHEM. DIV.. DEP. SCI. IND. RES., PETONE. N.Z, N Z J SCI 2) (3), 1978 (RECD. 1979). 371-376. Coden: NZJSA Language: ENGLISH Non-dI specs 1ve X- ray fluorescence has valuable forensic appllcatlons In New Zealand and loci udes Identification of holes In heav11y bloodstained mater lal such as bullet holes with Pb or Cu conten t: ma tchIng of pa lot smears and cosmetic traces wIth the Ir sources: analys Is and sourcing of glass fragments and cannnb Is, and the I dent Iflcatlon of a charred object such as a fir e accelerant from Its Cr content. The high Cl content of 1 sample Indicated that It burned In the presence of PVC [pol yvlnyl chloride], The technique was used In 1 case where a fingerprint suppo sedly disappeared. This technique Is versatl le and non-dostruc tlve. It also provides spectral Information Descriptors: BLOOD STAIN CANNABIS CHROMIUM LEAD COPPER PAINT COSMETIC GLASS FIRE ACCELERANT POLY VINYL CHLORIDE FINGER PRINT HUMAN NEW-ZEALAND Concept Codes: GENL BIOL-FORENSIC SC IENCE(*00531); RADIATION BIOL-RADTN.ISOTOP TECH(*0650-1 ); BIOCHEM METH-GENERAL( 10050); BIOCMEM METH-M1NERALS(10059); 8I0PHYS-GENERAL BIOPHYS TECH(* 10504); EXTERN EF F-GENL STUD( 10602): CHDRDAT E BODY REGN5-EXTREMITIES(11318): BLOOD/BODY FLDS-GENL STUDS,METMS(15- 001 ) Blosystemat1c Codes: CANNABIDACEAE(25738); 110M1NIDAE(86215) 67071216 SYNTHESES OF DL SERINE AND OF PRECURSORS THEREOF GLYCOLALDEHYDE AND MASKED GLYCOLALDEHYDES/ BASSIGNANI L; BIANCINI B; BRANDT A; CACIAGLI V; BIANCHI G E: RE L: ROSSODIVITA A; ZAPPELLI P SNAMPROGETTI SOC. AZIONI, L, P. M.. VIA ERCOLE RAMARINI 32. M0NTER0T0ND0. ITALY. CHEM BER 112 (1). 1979. 148-160. Coden: CUBEA Language: ENGLISH On treatment of vinyl chloride epoxide wtth(4) with water, of qhloroethy 1 one carbonate with aqueous bases, of vinyl acntnto or othyl vinyl other with aqueous potassium chlorate and catalytic amounts of osmium tetroxlde, g1yco1 a 1dehyde was formed (scheme 1). The aldehyde 5 (not Isolated), when submitted to the Ze11nsky-StadnIkoff amino acid synthesis, afforded 01 -serine In 70% yield. The latter method, when applied directly to the masked g1yco1 a 1dehydos vinyl acetate epoxide, 1, 1.2-tr lacetoxy ethane, chlorethyIene carbonate and acetoxyothy1ene carbonate 2, 7, 9, 10, vlnylene carbonate 2,5-dIch1orodIoxone or 2,5-dI acetoxydIoxane also gave DL-serlne (yields 35-70%), whereas with 4 no serine formation could bo detected (scheme 1). Concept Codes: BIOCHEM METH-PROTNS,PEPTDS.AM AC(* 10054); BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD - PROTE1 NS.PEPTIDES.A- MIND (nncaI 6 706 4 2 7 7 EXPERIMENTAL STUDIES FOR CORRECTION OF THRESHOLD VALUES OF VINYL CHLORIDE NOSKO M SCI. INST. HYG. OCCUP. DIS.. MED. ACAD.. SOFIA. BULG. KHIG ZDRAVEOPAZ 21 (4). 1978. 348-355. Coden: KHZDA Language: BULGARIAN An Inhalation experiment was conducted with 2 concentrations of vInylch1 or I do, 6.15 and 17.51 mg/m3, on white rats for 5 mo. Its action on liver functions and peripheral blood was examined in the experimental animals. pregnant ones and 3 Offspring. Basic liver functions, enzymatic, excretory, dextoxic and metabolic. were disturbed. Dose-dependont response was found for the activity of .alpha.-GTP, clas. LAP, OKT (ornithine carbamyl transferase). GPT (alanine transaminase), GDH (glycerophosphate dehydrogenase) , LDH (lactic dehydrogenase), bilirubin and Indices of fat metabolism. Histologic studies revealed analogous changes. The changes In the blood vessels and parenchymatous dystrophy were more manifest at the higher concentration. A now temporary threshold value for v1nylchi or 1de In air at the working place of 0.06 mg .cntdot. m3 was proposed. Descriptors: RAT DYSTROPHY ORNITHINE CARBAMYL TRANSTERASE ALANINE TRANS AMINASE GLYCERO PHOSPHATE DEHYDROGENASE LACTIC DEHYDROGENASE Concept Codes: MICROSCOPY-HISTOL,HISTOCHEM TECH(01056); ECOLOGY-LIMNOLOGY(07514 ); BIOCHEM STUD-PROTEINS,PEPTIDES, AMI NQ^ ACD(10064); BIOCHEM STUD-PORPHYRNS.8 ILE PIGM( 10065); ENZYMES-GEN,COMPAR STUD.COENZYMS( 10B02); ENZYMES-PHYSIOLOGICAL STUOIESt* 10808); METABOLISM-GENL STUD,ME T AB PATHW( 13002); METABOLISM-LIPIDS( * 13006); DIGESTIVE SYST-PHYSIOL.BIOCHEM( < 14- 004); CARD IOVASC SYST-PHY5I0L,BI0CIIEM( 14504 ) ; BL00D/U00Y FLDS-BLOOD,LYMPH STUD(15002): RESPIRATORY SYST-GENL STUD,METHS( 16001); REPRODUCT SYST-PHYSIOL,BIOCHEM( 16504); ROUTES OF IMMUNIZ.INFECT.THERAPf22100): TOXI COL - ANT I DOTES . PRE VENT IVE(22505); TOXI COL-ENVIRONMNTL,INDUSTR(* 22506); PEDIATRI- CS(25000): ENVIRON HEALTH-OCCUPATNL HEALTH(*37013): ENVIRON HEALTII-AIR.WATR.SL P0LLN(37015) B losystematIc Codes: MOM INIDAE(86215) R&s 138494 DIALOG F11e5: QIOSIS Previews 77-83/dan BA7502:RRM24UXilo55) (c. BI0S1S 1982) (Item 455 of 858) User 3614 25Jan83 2140 67063 1 64 EFFECT OF VEHICLE ON PILOCARPINE INDUCED MIOSIS SAARI M; KOSKELA P; MASAR S-E UNIV. EYE HOSP., KA JAANINTI E 50. SF-90220 OlJt U 22, F I NL . ACTA OPHTHALMOL 56 (4). 197B. 496-503. Coden: ACOPA Language: ENGLISH To determine the effect of 1 . A"/, polyvinyl alcohol (PVA) and castor oil vehicles on the p11ocarp1ne-Induced miosis, the miotic effect of 2% pI 1ocarpIne-PVA and oily drops on A young and 10 elderly people was studied and the miotic effect of A'/. pI 1ocarpIne-PVA and oily drops on 13 elderly people was studied. The miosis developed fast within 15 min, and maximum miosis was reached within 1 h. Oily drops of pilocarpine (nduced stronger maximum miosis than correspond Ing PVA-drops. The pupil remained contracted to less than 50% of its starting diameter after pI IocarpIne-PVA drops for 3-4 h and after oily drops for 9 h and returned to Its starting diameter after pilocarpIne-PVA drops 9-10 h and after oily drops 20-24 h following administration. The difference In the effect between pI 1ocarp I ne-PVA and oily drops was independent of the subjects' age. Descriptors: AUTONOMIC-DRUG OPHTHALMIC-DRUG CASTOR OIL POLY VINYL CHLORIDE PHARMACEUTI CAL-ADJUNCT AGE DIFFERENCE NEGATIVE Concept Codes: BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-LIPIDS( 10066); METABOLISM-GENL STUD,ME TAB PATHW(13002); METABOLISM-LIPIDS( 13006); MUSCLE SYST-PHYSIOL,BI0CHEM(* 17504); SENSE ORGANS-PHYSIOL,BIOCHEM(*20004); NERVOUS SYST-PHYSIOL.BI - 0CHEM(20504); PHARMACOL-GENERAL STUD IES(*22002); PHARMACOL-DR- UG METAB,METAB STIMU(22003); PHARMACOL-MUSCLE SYST(*22022 ) ; PHARMACOL-NEUROPHARMACOLOGY(22024); PHARMACOL-SENSE ORGANS( * - 22031): OEVELOPMNTL BIOL-GEN MORPHGENSIS(25508); PLANT PHYSIOL-CHEM CONSTITUENTS(51522); AGRONOMY-OIL CROPS(52514); PHARMACQGNOSY/PHARMACEUT BOTANY(54000) Blosystemat1c Codes: EUPHORBIACEAE(26055): RUT ACEAE(26685) 67062380 TEST USING POLY VINYL CHLORIDE BANDS WITH AN ADHESIVE LAYER FOR DIAGNOSING ENTEROBIASIS IN LENINGRAD USSR BEREZANTSEV YU A; MEZHAZAKIS F I; LAVROVA V P LENINGR. SANIT.-HYG, MED. INST.. LENINGRAD. USSR. MED PARAZITOL PARAZIT BOLEZNI 47 (4). 1978. 106-107. Coden: MPPBA Language: RUSSIAN Data are presented from a 4-yr study of enterobiasis In children's nurseries and kindergartens In the Leningrad area (Russian SFSR, USSR). Use of a polyvinyl band with an adhesive strip was more effective than the perianal scrape In diagnosing the disease. More efficient diagnosis resulted In a decrease in enterobiasis cases. Descriptors: CHILDREN PERI ANAL SCRAPE Concept Codes: PATHOLOGY-DIAGNOSTIC(* 12504 ): PATHOLOGY-THER- APY( 12512): DIGE5TIVE SYST-GENL STUDS,METHS( 14001); DIGESTIVE SYST-PATIIOLOGY( * 14006) : ROUTES OF IMMUNI Z , I NF ECT , Tl IER AP ( 22 100 ) ; PEDIATRICS(25000): PUB HEALTH-AOMINISTR,STrtTISTICS(370(0): EPIDEMIOL-COMMUNI CABLE DISEASES(*37052); PARASITOLOGY-MEDICAL- D losystemat lc Codes: NEMATODA(51300): MOM IN1DAE(862 I 5 ) 67057845 THE SUITABILITY OF SIMULANTS FOR FOODSTUFTS COSMETICS ANO PHARMACEUTICAL PRODUCTS IN MIGRATION STUDIES FIGGE K; KOCH d; FREYTAG W UNILEVER FORSCHUNGSGES.. MBH, BEHRINGSTR. 154. 2000 HAMBURG 50. W. GER. FOOD COSMET TOXICOL 16 ( 2). 1978. 135-142. Coden: FCTXA Language: ENGLISH In connection with the control of packaging materials for human use, a radiotracer technique Is being used In migration studies designed to determine the best simulants for the most important foodstuffs and the test conditions of time arid temperature most representative of the storage conditions used In practice for any given type or food. Several 14C-!abeled plastics additives were synthesl7ed. Incorporated into plastics compounds and compression-molded Into test sheets. These sheets were stored for various periods In contact with selected food, pharmaceutical. hair-care and cosmetic products, as well as with food simulants proposed by the EEC authorities, at several different temperatures. The amounts of labeled additives migrating from rigid PVC [polyvinylchloride] Into any of the products were very small. The level of migration from high-density polyethylene was generally much higher, particularly for the relatively small and volatile BUT [butylated hydroxy to 1uene] molecule, but results varied widely with different contact media. In comparative studies with BUT containing HD/PE [high density polyethylene) there was closer agreement of migration levels between the few fat-conta InIng foods and the test fat than with the aqueous food simulants. For most of the pharmaceuticals and cosmetic products appropriate simulants must be Identified. Descriptors: HUMAN POLY VINYL CHLORIDE HIGH DENSITY POLY ETHYLENE BUTYLATED HYDROXY TOLUENE Concept Codes: RADIATION BIOL-RADTN.ISOTOP TECH(06504): BIOCIIEM-GASESC 10012): BIOCHEM STUD-GENERAL(* 10060); BIOCHEM STUD-LIPIDS(10066); BIOPHYS-MOLECUL PROP.MACROMOLECf 10506): EXTERN EFT-TEMPERATURE(10614); MOVEMENT( 12100 ) ; TOOD TECH-EVALNS PHYS.CHEM PROPS ( 1 3530 ) ; FOOD TECH-PREP , PROCESSNC.. - STORAGE(* 13532 ) : INTEGUMENT SYST-GENL STUDS.METHS( I 850 1 ) : PIIARMACOL-GENERAL STUDIES( 22002); TOXI COL-GENL/EXP STUDS.MET- HS(22 501); TOXI COL - FOOD.RESIDS.ADD IT,PRESRV(22502 ): TEMPERA TURE - GENL . ME Tl IS ( 2300 1 ) B I osys tema tIc Codes: ORGANISMS-UN$PECIFI ED(00500); HOMINIDA- E(862 15) DIALOG BIQSIS Previews 77-B3/Jan Bi R&S 138495 ) (c. BI0S1S 1982) (Item 458 of 858) User 3614 25JnnB3 2 14 1 67052552 EXPERIMENTAL STUDY ON NONTHROMBOGENIC LEFT HEART BYPASS KINUGAWA N DEP. SURG.. OKAYAMA UNIV. MED. SCH., TSUSHIMA, OKAYAMA, JPN. OKAYAMA IGAKKAI 2ASSHI 361-374. Codon: OIZAA 89 (3-4), 1977 (RECD. 1978). Language: JAPANESE A new technique Is described to facilitate descending thoracic aorta replacement [In hybrid dogs] without the usp of antIcoagu1 ants. To eliminate the need of anticoagulants, tubes and cannulas are coated with nonthrombogenIc polyurethane-polyvInyl-graph 1te (PPG). The loft heart bypass using them can provide a dry operative field. No significant changes were observed In clotting time and prothrombin time during this nonthrombogen1c left heart bypass. Under scanning electron microscopy the majority of platelets were solitarily dispersed and a few platelets were aggregated to each other on the PPG-coated tube. They were uniformly spherical or spheroidal with short spiny projections and long pseudopods. Platelet aggregations were present but metamorphoses of the platelets and fibrin net formation were not observed.' These findings of PPG-coated tubes were similar to those of uncoated polyvinyl chloride tubes In heparlnlnzed left heart bypass. PPG-coated tube showed a tendoncy to depress platelet transformat Ion In the early stage of thrombus formation. Neither silicone tubes nor uncoated polyvinyl chloride tubes prevented platolet transformation. Descriptors: DOG POLY VINYL CHLORIDE POLY URETHANE POLY VINYL GRAPHITE HEPARIN ANTICOAGULANT SILICONE TUBE FIBRIN NET CLOTTING TIME PROTHROMBIN TIME PLATELET AGGREGATION SCANNING ELECTRON MICROSCOPY Concept' Codes: ELECTRON MICR0SC0PY(O1O58): BIOCHEM STUO-GENERAL(10060); BIOCHEM STUD-PROTEINS,PEPTIDES.AMINO ACD(10064);' MINERALS!10069); BIOPHYS-GENERAL BIOPHYS TECH( 10504); BIOPHYS-MEMBRANE PHENOMENA( 1050B); ANATOMY/HISTO- L-SURGERY(11105); ANATOMY/HISTOL-MICRO,ULTRAMICRSC(11108); PATHOLOGY-THERAPY( 12512); CARDIOVASC SYST-GENL STUDS.METHS(*1 - 4501); CARDIOVASC SY5T-HEART PATHOLOGY(+1450G); CARDIOVASC SY5T-BI.D VESS PATIIOL ( * 14508 ) ; BLOOD/BODY r LOS-BLOOD , LYMPII STUD(* 15002); BLOOD/BODY FLDS-BLOOO CELL STUDS(* 1 5004 ) B lnsystem.it Ic Codes: CANI DAE ( 85765 ) G7()52534 FLEXIBLE VALINOMYCIN ELECTRODES FOR ON-LINE DETERMINATION OF INTRA VASCULAR AND MYO CARDIAL POTASSIUM IONS HILL J L; GETTES L 5; LYNCH M R; HEBERT N C DEP. MFD., UNIV. KY. COLL. MED., LEXINGTON. KY. 40506. USA. AM J PHY5.I0L 235 (4 ). 1978. H455-II459. Codon: AdPIIA Language: ENGLISH Flexible electrode systems capable of monitoring In vivo changes In venous and myocardial extracellular potass Him activity were constructed using va1 InomycIn-po1yvIny1 chloride matrix membrane and polyvinyl chloride tubing. Electrode Impedance was 1-30 m.OMEGA., time Constant 10-200 ms, drift < 1 mV/h, and shelf life .apprx. 3 days ( I n t rninyocard I a 1 electrode) and .apprx. 6 wk (venous electrode). In vitro and In vivo accuracy were determined In 5 dogs nnrl 10 pigs, anesthetized with sodium pentobarbital (35 mg/kg t.v.). with normal andelevated Kt levels. Serum and venous K+ concentration, determined using a KE electrode with tip diameter of 1.5 mm, correlated well to serum K+ values determined by flame photometry (r (correlation coefficient) >= 0.997). Steady-state myocardial extracellular K+ concentration determined using double-barrel electrodes with total tip diameter of O.G mm correlated well to the serum Kt concentratI on (r - 0.992). These electrode assemblies permit on-line, virtually Instantaneous In vivo detprmInatI on of Intravascular and local myocardial extrace I 1u1 or K+ activity, a capability not previously available. Descriptors: DOG PIG POLY VINYL CHLORIDE SODIUM PENTO BARB IT 01. CENTRAL DEPRESSANT GENERAL ANESTHETIC Concept Codes: CYTOLOGY/CYTOCHEM-AN IMAL(02506); MATHEMATIC BIOL/STATISTIC METH(04500): BIOCHEM METH-MINERALS( 10059): BIOCHEM STUO-GENERAL(10060): MINERALS(t0069); BIOPHYS-GENERAL BIOPHYS TECH(10504); BIOPHYS-MEMBRANE PHENOMENA(10508); MINERALS(* 13010); CARDIOVASC SYST-GENL STUDS.METHS( * 14501 ) : CARDIOVASC SYST-PHYSIOL,BIOCHEM!14504); BLOOD/BOOY FLDS-GENL STUDS,ME THS( 1500 I): BLOOD/BODY FLDS-BLOOD,LYMPH STUD( 15002); MUSCLE SYST-GENL STUOS.METHS(17501); MUSCLE SYST-PHYSIOL.BIOC- HEM( 17504); NERVOUS SYST-GENL STUDS,METHS(2050 1 ); PHARMACOL-N- EUROPHARMACOLOGY ( 2.2024 ) ; IN VITRO ST UOS - CE LLUL R , SUBC E L L ( 3 2600 ) B losystematIc Codes: SUIOAE(85740): CANIDAE(85765 ) 67052097 INVESTIGATION OF LIPID MEMBRANES WITH STABILIZER PART 1 FORMATION AND PROPERTIES OF STABILIZED LIPID MEMBRANES SHCHIPUNOV YU A; PRYAZHEVSKAYA I S INST. CHEM,. FAR-EAST-SCI. CENT.. ACAD. SCI. USSR. PR 100 LET VLADIVOSTOK 159. VLADIVOSTOK 22, USSR. STUD BIOPHYS 71 (3).. 1978. 151-16 1. Coden; STBIB Language: RUSSIAN The formation and properties of bllayer lipid membranes with stabilizers are described. If a linear polystyrene Is Incorporated Into a bllayer Itpld membrane formed from fatty monog1 year Ides, the lifetime Increases 10-15 times and tno breakdown voltage Increases 2-3 times. Polyvinyl chloride and wax wero also used for membrane stabilization. The following mixtures wore used as solvents: mothy1 -caproate with n-decano. dloxano with n-Uecano and chloroform with n-ilocnno. Descriptors: LINEAR POLY STYRENE WAX POLY VINYL CHI OR I OF Concept Codes: BIOCHEM STUD-GENERAL(10060): BIOCHEM STU0-L1PI0S( * 10066); BIOPHYS-MEMBRANE PIIENOMFNAI * 10508 ) DIALOG FtleS: DIOSIS Previews 77-83/Jan 8A7502;RRM24 R&S SIS 1902) litem 461 of 858) User 3614 25jan83 2 14 2' 6705 14 I 1 GAS CHROMATOGRAPHIC DETERMINATION OF 1 1 t TRI CHLORO ETHANE IN VINYL CHLORIDE POLYMERS AND IN FOODS GILBERT J; STARTIN J R; WALLWORK M A FOOD SCI. DIV. , MINI ST. AGRIC. FISH. FOOD. HALDIN HOUSE. QUEEN ST.. NORWICH NR2 4SX, NORFOLK. ENGL.. UK. J CHROMATDGR 160 (1). 1978. Language: ENGLISH 127-132. Coden: JOCRA A gas chromatographic method Is described for the quantification of levels of 1, 1. 1 -trIchIoroethane In vinyl chloride polymer resins and In poly(vtnyl chloride) (PVC) bottles used In the packaging of foods. By application of electron-capture detection the method can be extended to foods wh1ch were stored In PVC botties and 1, 1.1-trlchloroethane can be estimated with a limit of detection In the foodstuff of between 0.002-0.01 ppm. depending on the food. The results of a small survey of the amounts of this compound In PVC bottles and foodstuffs purchased from retail outlets are reported. Descriptors: PACKAGING ELECTRON CAPTURE DETECTION Concept Codes: BIOCHEM METH-GENERAL(*10050): BIOCHEM STUD-GENERAL{10060); BIOPHYS-GENERAL BIOPHYS TECH(10504); MOVEMENT(12100): FOOD TECH-GENL STUDS.METHS(* 13502); FOOD TECH-EVALNS PHYS.CHEM PROPS(13530); FOOD TECH-PREP.PROCESSNG- .STORAGE(* 13532); TOXICOL-FOOD,RESI OS.ADDIT.PRESRVf*22502); NEOPLSMS/NEOPL AGNTS-CARCINOGENS(24007) 67046041 SURFACE MORPHOLOGY OF POLY VINYL CHLORIDE AND SILICONE ELASTOMER UMBILICAL ARTERY CATHETERS BY SCANNING ELECTRON MICROSCOPY CLAWSON C C; BOROS S J CHILD. HOSP.. 311 PLEASANT AVE., ST. PAUL. MINN. 55102. USA. PEDIATRICS 62 (5). 1978. 702-705, Coden: PEDIA Language: ENGLISH Tho surface features of a new silicone elastomer umbilical artery catheter were defined by scanning electron microscopy and compared with those of a standard polyvinyl chloride catheter. Little difference was noted In the surfaces of the catheter materials themselves, but the radiopaque material used to render the catheters visible by X-ray resulted In a considerable difference In tho overall smoothness. The polyvinyl chloride catheter's marker was In tho form of a wldo, rough band extending the length of the tubing whereas tho marker particles of the silicone elastomer wore dispersed, more uniform In size and resulted In less overall Irrogularlty of tho surface. Dnscrtptors: X-RAY Concept Codes: PHOTOGRAPHY-METI1S.MAILS,APPARAT(O1012); ELEC 1 RON MICROSC0PY(01O5B) ; RADIATION BIOL-RADTN,ISOTOP TECIM 06504); BIOCHEM STUD - GENERAL(10060); MINERALS(*100G9); BIOPHYS"GENERAL BIOPHYS TECH( 10504); BIOPHYS-BI DENG INE ERING(* - 10511): ANATOMY/HI STOL-RADIOLOGIC! 1 1 IOTj) ; ANMOMY/1IIST0L-MICR- O.ULTRAMICRSCf*11100): CAROIOVASC SYST-GENL 51UDS.METI IS(1450- 1) 67039995 EFFECTS OF VINYL CHLORIDE EXPOSURE ALONE AND IN COMBINATION WITH TRYPAN BLUE APPLIED SYSTEMATICALLY DURING ALL THIRDS OF PREGNANCY ON THE FETUSES OF CFY RATS UNGVARY G: HUOAK A; TATRA I E; LORINCZ M; FOLLY G OEP. EXP. PATHOL. CHEM,, STATE INST. OCCUP. HEALTH. P.O. BOX 22. H-1450, OUDAPFST, HUNG. TOXICOLOGY 11 (1). 1978. 45-54. Coden: TXCYA Language: ENGLISH Vinyl chloride (VC) Is present In the fetal and maternal blood and In the amnlotlc fluid after the exposition of pregnant CFY rats to VC at an atmospheric concentration of 5500. 18.000 or 33.000 mg/m3 (.npprx, 2000. 7000 or 12.000 ppm) for 2.5 It on the 18th day of pregnancy. Indicating the permeability of the placenta to the agent. Terato 1og I ca 1 Investigation of the offspring of pregnant rats exposed continuously to VC at an atmospheric concentration of 4000 mg/m3 air (1500 ppm) during the 1st. 2nd or last 3rd of pregnancy showed that VC has no terato IogIca1 effect In the rat and has no embryotoxlc effects either, when applied during the 2nd or last 3rd of pregnancy In the above concentration. Exposition to VC during the 1st third of pregnancy resulted in an Increased fetal mortality and In the manifestation of embryotoxlc effects. Fetal losses and Induction of CNS malformation due to trypan blue adm1 nstrat1 on were not potentiated by a combined exposure of pregnant rate to VC and the dye. Descriptors: TERATOGEN CENTRAL NERVOUS SYSTEM MALFORMATION MORTALITY Concept Codes: BIOCHEM STUD-GF.NERAL ( 10060 ) : B I OPHYS-MEMBRANE PHENOMENA( 10508): MOVEMENT(12100); PATHOLOGY-NECROSIS( 12510); BLOOD/BOOY FLOS-BLOOD.LYMPH STUD( 15002); BLOOD/BODY FLDS-0THER BODY FLDS( 15010): RESPIRATORY SYST-GENL STUD.METHS( 1600 1 ) : REPRODUCT SYST-PHYSIOL.BIQCHEM( 16504); NERVOUS SYST-PATHOLOGY - (20506); ROUTES OF IMMUNIZ,INFECT,THERAP(22100): TOXtCOL-GENL- /EXP STUDS.METHSf *22501); TOXI COL-ENVIRONMNTL.INDUSTR(22506): DEVELOPMNTL BIOL-PATHOLOGICAL(25503); OEVELOPMNT L BIOL-EXPER TERATOL(*25554) Blosystemat1c Codes: MURIDAE(86375) ; BIOSIS INTERNAL USE(97 000) DIALOG Flle5: QIOSIS Previews 77-83/Jan BA7D02-.RRM2 R&S 1 67038481 INFLUENCE OF ORGANIC TIN STABILIZER FOR POLY VINYL CHLORIDE AOVASTAB MOL-17 ON SOME BIOCHEMICAL AND MORPHOLOGICAL INDICES UNDER EXPERIMENTAL CONDITIONS RADEVA M; BOROV B; KR'STEV L; ANGEL 1 EVA R INST. HYG. OCCUR. DIS., ACAD. MED., SOFIA. BULG. KHIG ZDRAVEOPAZ 20 (5). 1977 (RECD 1978) 437-442. Coden: KHZQA Language: BULGARIAN White female rats, weighing 150-160 g. were treated with the organic tin compound Advastab Mol 17 In a dose of 220 mg/t<g orally. The following were studied on the 6th h. 24th h. 4th day, 10th day and 20th day: the activities of glutamic oxalacetlc transaminase [GOT], glutamic pyruvic transaminase [GPT]. alkaline phosphatase [AP], succinic dehydrogenase [SDH J, glutamic dehydrogenase [GLDH ] , catalase and the amount of soluble protein In liver; the activity of the same enzymes without catalase In blood serum; the amount of Sm In liver, kidney, spleen and myocardium; and pathomorphoIogIc changes In Internal organs. They found toxic damage of liver, most manifested on the 24th h, presenting an Increased activity of AP and lower activity of catalase and GPT. There was an Increased activity of the enzymes AP and GPT In blood serum. The activity of AP was altered mostly and permanently. Pathomorpho1og1c examination revealed acute venous stasis and dystrophic changes, presenting the type of parenchymatous and vacuolar dystrophy. They were mostly manifested on the 24th h after administration of the substance. There were high concentrations of Sm In all examined organs. especially In liver and kidney 6 h after administration of the compound. The amount of Sm In liver, kidney, spleen and myocardium at this stage were, respectively. 189, 418, 152 and 170 .times, higher than that of the control animals. Descriptors: RAT LIVER DAMAGE KIDNEY SPLFEN MYO CARD IUM BLOOD SERUM GLUTAMIC PYRUVIC TRANS AMINASE GLUTAMIC OXAL ACETIC TRANS AMINASE ALKALINE PHOSPHATASE SUCCINIC DEHYDROGENASE GLUTAMIC DEHYDROGENASE CATALASE VENOUS STASIS PROTEIN Concept Codes: BIOCHEM STUD-PROTEI NS.PEPTIOES.AMI NO ACD( 10064); BIOCHEM STUD-PORP! IYRNS.BILE PIGM( 10065); MINERALS(10069); ENZYMES-PHYSIOLOGICAL STUD1ES(*10808); PHYSIOLOGY-GENERAL STUD IES(* 12002); MINERALS(*13010); METABOL ISM-PROTNS , PEPTDS , AM ACDS( 13012 ) ; DIGESTIVE SYST-PAT1I0L0GY( 1- 400G); CARD IOVASC 5YST-PHYSIOL.BIOCHCM( 14504 ); CARDIUVASC SYST-BLD VESS PATHOL(*14508); BLOOD/BODY TLDS-BLOOD.LYMPII STUD( 15002); BLOOD/BODY FI.DS-LYMPHAT TISS . RES( 15008); URIN SYST/EXT SECR-PHYSL,BIOCHEM!15504); DENTAL/ORAL BIOL-GENL STUD.METHS(19001); ROUTES OF IMMUNIZ.INFECT.THERAP(22100); TOXICOL-GENL/EXP STUDS.METHS(*22501) B 1 osysteniat Ic Codes: MURIDAE(86375) 3SIS 1982) (Item 464 of 858) User 3614 25Jan83 2M3 LAB. POLYM. , MOSC. TECHNOL, INST. MEAT DAIRY I NO. . MOSCOW. USSR. VOPR PITAN (3). 1978 72-74. Coden; VPITA Language: RUSSIAN A technology was developed for obtaining coatings based on aqueous dispersions of BXBD-65 (a copolymer of vinyl and v I ny1 1 dcnooh1 or I do) and butyl rubber which possess physico-chemical properties required to ensure biochemical processes attending maturing of cheese. GLC showed that the diffusion of the solvent remnants occurs only In the layer of the cheese In Immediate contact with Its coating and In amounts below the premlsslble concentratI on. V Iny1ch1 or 1de was absent tn the coating and In the cheese enclosed In the coatIng. Descriptors: BXBD-65 VINYL CHLORIDE VINYLIDENE CHLORIDE BUTYL RUBBER Concept Codes: BIOCHEM METH-GENERAL(10050): BIOCHEM STUD-GENERAL(10060); BIOPHYS-GENERAL BIOPHYS TECHC10504); MOVEMENT( 12lOO); FOOD TECH-DAIRY PRODUCTS(* 1 35 I 8 ) ; FOOD TECU-PREP,PROCESSNG,STORAGE(* 13532); TOXICOL-GENL/EXP STUDS.M- ETHSt*22501); TOXI COL - FOOD,RESIDS.ADD IT.PRESRV(* 22502 ) : TOXIC OL - ENVI RONMNT L . INDUSTR ( 22506 ) ; NEOPLSMS/NEOPL AGNTS-CARC INOGENS(24007) Blosystomat Ic Codes: MAMMAL I A-UN5PEC1FI ED AND EXTINCT(857001 67038433 GAS LIQUID CHROMATOGRAPHY INVESTIGATION OF MIGRATION INTO CHEESE- OF VOLATILE COMPONENTS OF COATINGS BASED ON AQUEOUS POLYMER DISPERSIONS TARASOVA N A; SNEZHKO A G; DONTSOVA E P; VENEDIKTOVA L V DIALOG F(le5: BIOSIS Previews 77-83/Jan BA7502:RRM24Q2(See F R&S 138498 ) (Item 466 of 858) User 3614 25jan83 2 144 670384 16 establishing a protocol from laboratory studies to be used IN FIELD SAMPLING OPERATIONS GR07E A A; KIM W S; .KUPEL R E PUBLIC HEALTH SERV., DIV. PHYS. SCI. ENG.. NATL. INST. OCCUP. SAP. HEALTH. CINCINNATI, OHIO 45226, USA. AM IND HYG ASSOC J 39 ( 11), 1978 880-884. Coden: AIHAA Language: ENGLISH A laboratory procedure Is described that was used In determining the breakdown products of plastic compounds used In l.njectlon molding operations. These compounds Include polyvinyl chloride, polystyrene, aery 1 on ItrI 1e-butad I one-styr- ene. methyl methacrylate, polyethylene. polypropylene and nylon [occupational hazards to humans). Laboratory samples were generated at Injection molding temperatures and collected on various solid sorbents. Detector tubes were used for qualitative Information to Indicate whether certain classes of compounds wore present. Compounds Identified from the analyses of these laboratory samples are listed. Qualitative gas chromatography-mass spectrometry (GC/MS) data obtained from charcoal tube samples collected at a tire molding and a rubber producing company are also presented. Descriptors; HUMAN POLY 'VINYL CHLORIDE POLY STYRENE ACRYLONITRILE BUTADIENE STYRENE METHYL METHACRYLATE POLY ETHYLENE POLY PROPYLENE NYLON OCCUPATIONAL HAZARD Concept Codes: SOCIAL BIOL/HUMAN ECOLOGY(05500); BIOCHEM METH-GENERAL( 10050); BIOCHEM STUD-GENERAL( 10060); 8 IOPHYS-GEN ERAL BIOPHYS TECH(10504); EXTERN EFF-TEMPERATURE(106H): MOVEMENTf12100); TOXI COL-GENL/EXP STUDS.METHS(*22501); TOXICOL-ENVIRONMNTL,INDUSTR(*22506); TEMPERATURE-GENL.METHSf 23001); PUB HEALTH-LAB METHSf *37006): ENVIRON HEALTH-OCCUPATNL HEALTH(*37013); ENVIRON HEALTH-AIR,WATR.SL POLLN(+37015) BIosystomat1c Codes: HOMINIDAE(86215) DIAGNOSIS Concept Codes: PHOTOGRAPHY-METHS.MATLS.APPARAT(0 10 1 2 ) : MICROSCOPY-HISTOL.HISTOCHEM TECH(01056); SOCIAL BIOL/I IUMAN ECOLOGY(05500): RADIATION BIOL-RADTN,ISOTOP TECH(*06504); BIOCHEM STUD-GENERAL( 10060); ANATOMY/HISTOL-RAD IOLOGIC( 1 1 106); ANATOMY/HISTOL-MICRO,ULTRAM ICRSC( 1 1 108); CHOR0ATE BODY REGNS-ABDOMEN( 1 13 14 ) ; PATHOLOGY-01AGN05TIC(12504); DIGESTIVE SYST-GENL STUDS.METHS( 14001); DIGESTIVE SYST-PATHOLOGY( * 14006) ; CARDlOVASC SYST-BLO VESS PATHOL(* 14508); BONE.JNTS.FASC.CON - N/AD IP-GENL( 18001); BONE.JNTS,FASC.CONN/AD IP-PATHOL( 18006); COELOM MEMBRANES.MESENTERIES.ETC(18200); TOXICOL-ENVIRONMNTL,- INDUSTR(*22506); NEOPLSMS/NEOPL AGNTS-DIAGN5 ME Til (* 2400 1 ) : NEOPLSMS/NEOPL AGNTS-PATH.CL INIC(* 24004); NEOPLSMS/NEOPL AGNT S-8 IOCHEM{24 006); ENVI RON HEALTH-OCCUPATNL HE ALTH( 370 I 3) B losystemat 1c Codes: H0M1NIDAE(862 15 ) 67036486 HEPATIC ANGIO SARCOMA DUE TO VINYL CHLORIDE REPORT OF 4 CASES ROCHE J; FOURNET J; HOSTEIN d; PANH M; BONNET-EYMARD J CLIN. HEPATOL.-GASTROENTEROL.. CENT, HOSP. UNIV. GRENOBLE. F 38700 LA TRONCHE, FR. GASTROENTEROL CLIN BIOL 2 (8-9). 1978 GG9-678. Coden: GCBID Language: FRENCH Four cases of angiosarcoma of the liver occurring In workers exposed to vinyl chloride are reported. From the study of these 4 patients and that of 37 patients reported In the literature. the clinical, biochemical and histological features of vinyl ch1 or 1de-assoc1 ated angiosarcoma of the liver are outlined. The main clinical finding Is hepatomegaly. The diagnostic value of hepatic artcr rogrnphy and the frequent occurrence of hemoper1toheum are stressed. The responslb I 1 Ity of vinyl chloride for the development of hepatic angiosarcoma Is discussed. Descriptors: HUMAN CARCINOGEN BIOCHFMICAL FEATURES rvnorPOP , r n - - /* .............................. - DIALOG F I 1 o5 : BIOSIS Prev1 ews. 77-83/dan BA7502 ; RRM2402( See Fi R&S 138499 (Item 468 of B58) User 3G14 25Jan83 2 145 67036305 INTERACTIONS OF VINYL CHLORIDE WITH RAT LIVER DNA IN-VIVO GREEN T; HATHWAY D E CENT. TOXICOL. LAB., IMP. CHEM. CHESHIRE SK10 ATJ, ENGL., UK. 1ND. LTD., ALDERLEY PARK. CHEM-BIOL INTERACT 22 (2-3). 1978 211-224. Codon: CBINA Language: ENGLISH 9.beta.-D-2'-Deoxyrtbof uranosyl-tmldazo-[2,1-1)purine ("etheno-deoxyadenosine") and 1 .beta.-D-2'-deoxyr1bofuranosy1 - - 1 , 2 - d 1 hydro-2-oxo- 1 rn Idazo- ( 1,2 -c ] -pyr 1 m 1 d I ne ("etheno-deoxycytIdlne") are Identified In the enzyme hydrolysates obtained from calf-thymus DNA which had been modified by chemical reaction with chioroacotn1dohyde and from liver DNA prepared from rats which had been exposed orally to vinyl chloride In their drinking water (250 ppm) for approx 1mato1y 2 yr. Vinyl ch1 or Ide-derIved chioroethy 1ene oxide and/or chioroaceta1dehyde behaves as a blfunction alkylating agent towards deoxyadennsIne and deoxycytIdIne residues of DNA. The separation of deoxyrIbonuc1eos1des and the 2 etheno-deoxyrIbosyl-nucleosIdes by liquid chromatography, and the mass spectra of etheno-deoxyadenosIne and etheno-deoxycytIdlne and of their 0-b 1 s - (tr I methy1sI 1y1) derivatives are described. In the animal experiment, the resulting proportion of etheno-dooxyadenosIne is small compared with that of etheno-deoxycytIdlne. Im I dazo[2, 1 - I ]pur- Ine (etheno-den1ne) Is Identified In the supernatant after sedimentation of the modified DNA In the model experiment, and in the product resulting from the reaction between chioroacetaIdehyde and deoxyadenos1ne. The effect on the structure of DNA of the 1m Idazo-cyc1 Iza11 on of deoxyadenos1ne and deoxycytId I ne residues and of the depurlnatton of etheno-deoxyadenos1ne residues Is discussed In relation to vinyl chloride oncogenicity. Descriptors: ETHENO ADENINE ETHENODEOXY CYTIDINE ETHENODEOXY ADENOSINE CALF THYMUS DNA CHLORO ACETALDEHYDE CFILORO ETHYLENE OXIDE IMIDAZO CYCLIZATION MA5S SPECTRA CARCINOGEN LIQUID CHROMATOGRAPHY MASS SPECTRA Concept Codes: BIOCHEM-PHYSIOLOGL WATER STUD(IOOM); BIOCHEM METH-GENERAL(10050); BIOCHEM METH-NUCL ACO,PURNS,PYRM(10052); BIOCHEM METH-PROTNS.PEPTDS,AM AC(10054); BIOCHEM STUD-NUCL ACD,PURNS,PYRM(10062); BIOCHEM STUD-PROTEINS,PEPTIDES,AMINO ACD(10064); BIOPHYS-GENERAL BJ0PHY5 TECH(10504); ENZYMES-METH- OD$(10'804); MOVEMENT ( 12100); ME TABOL I SM-GENL STUD , MET AB PATHW(13002); METABOLISM-NUCL ACD,PUR I NS,PYRIM( 1 3014); DIGESTIVE SYST-PHYSIOL.BIOCHEM(* 14004); ENDOCRINE SYST-THYMUS- (17016); DENTAL/ORAL BIOL-GENL STUD,METlIS( 19001): ROUTES OF IMMUNIZ.INFECT,THERAP(22100); TOXICOL-GENL/EXP STUDS.METHS(*2- 2501); NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007); PED I ATRICS(2 - 5000) BlosystematIc Codes: BOVIDAE(85715); MUR I DAE(06375) 1ST. SUPER. SANITA ORTO BOT.. UNIV. ROMA. ROMA. ITALY. CHEM-BIOL INTERACT 22 (2-3). 1978 297-308. Coden: CBINA Language: ENGLISH Twelve pesticides (az1nphosmethy 1. dial late. dlchlorvos. EPTC (ethyl N.N-d1propy1thIo1carbamate]. fench1orphos, mevlnphos. monocrotophos. noruron, parathIonmethy 1 . trial late, trlchlorfon and vegadex) were tested for the ability to Induce hist revertants In 4 hIstIdIne-requIrIng strains of S. typhlmurlum {T AI 535 (mlssense), T AI 536, TAI 537 and T AI 538 (frame-shIft)) and resistance to low levels of streptomycin In S. coellcolor. Dlchlorvos. which Is a phosphoric ester with a dI chiorovIny1 group as side chain. and trlchlorfon, which Is known for Its spontaneous conversion In dlchlorvos, are both mutagenic In S. typhlmurlum (strain T AI 535) and S. coellcolor. Five organophosphorus pesticides similar to dlchlorvos but devoid of the vinyl group are not mutagenic. Three carbamates (dial late. trial late and vegadex), which contain a chloroallyl group similar to the vinyl group of dlchlorvos. are mutagenic In S. coellcolor. Trial late and vegadex are powerful mutagens In S. typhlmurlum (strain TAI 535); 2 other carbamates devoid of the chlorinated group are not mutagenic. The presence of a vinyl chloride or allyl chloride group In the molecule of these pesticides apparently Is responsible for the ability to Induce point mutations In S. typhlmurlum strains and S. coellcolor. Other organisms may be similarly affected. Descriptors: TAI-535 TAI-536 TAI-537 TAI-538 STRAINS ORGANISM STREPTOMYCIN AZINPHOS-METHYL DIALLATE ETHYL-N N-DI PROPYL THIO CARBAMATE FENCHLORPHOS MEVINPHOS MONOCROTOPHOS NORURON PARA THI ON-METHYL TRIALLATE TRICHLORFON VEGADEX VINYL GROUP ALLYL GROUP HISTIDINE Concept Codes: GENET ICS/CYTOGENET-GENL STUD IES(-03502); BIOCHEM STUD-GENERAL(* 10060); BIOCHEM STUD-PROTEI NS.PEPTIDE5. - AMINO ACO( 10064 ); BIOCHEM STUD-CARBOHYDR. ( 10068); BIOPHYS-MOL- ECUL PROP,MACROMOLEC( * 10506); PHARMACOL-GENERAL STUD IES(* 2200- 2); TOXICOL-GENL/EXP STUDS.METHS(*22501); BACTERIAL AND VIRAL GENETICS!*31500): CHEMOTHERAPY-GEN STUD.METH.ME TAB(38502 ) ; PEST CONTRL GENL/PEST ICS/HERBICS(54600): ECONOM EN70M0L-CHEM PHYS CONTRL(60016) BlosystematIc Codes: ORGANISMS-UNSPECIFI ED(00500); ENTEROBA- CTERIACEAE(04810); STREPTOCOCCACEAE(05514); ABSTRACTS OF ENT0M0L0GY196000) 67035050 MUTAGENICITY OF DICHLORVOS AND OTHER STRUCTURALLY RELATED PESTICIDES IN SALMONELLA-TYPHIMURIUM AND STREPTOMYCES-COELICO- LOR CADFPF A * n D T A I T W A * fAnnAMOMC r> . O n mrn r* DIALOG F 1 1e5: BIOSIS Previews 77-B3/Jan BA7502;RRM24Q2( See FUe55) R&S 138500 470 of 858) User 3614 25jan83 2 146 67034380 PENETRATION OF 7 COMMON FLEXIBLE PACKAGING MATERIALS BY LARVAE AND ADULTS OF 11 SPECIES OF STORED PRODUCT INSECTS CLINE L D STORED-PROD. INSECTS RES. DEV. LAB., US FED. RES.. SCI. EDUC. ADM.. SAVANNAH, GA, 31403, USA. J ECON ENTOMOL 71 (S). 1978 726-729. Coden: JEENA Language: ENGLISH The ability of larvae to penetrate flexible packaging materials was determined for large and small larvae of 11 spp. of stored-product Insects. These Insects were confined Individually, with or without food. In small pouches made of cellophane, polyethylene, paper, polyvinylchloride. aluminum foil, polyester or polypropylene. Larvae of Oryzaephllus mercator (Fauvel). Cathartus quadr1 col 11s (Guer|n-Menev111e) and Cryptolestes puslllus (Schoenherr) made no penetrations. Trlbollum castaneum (Herbst) larvae were very weak penetrators. Only Tenebroldes maurltanlcus (L.) and Trogoderma varlabile Ball Ion larvae penetrated all 7 materials. Larvae of the 5 other spp.. Dermestes maculatus De Geer, Lasloderma serrlcorne (F.). Ephestla cautella (Walker), Corcyra ccphalonlca (Stalnton) and Plodla Intorpuncto 11 a (Huebner), penetrated 5 of of the 7 materials. Foil, polyester arid polypropylene were generally the most resistant to penetration. Larvae of all species generally showed a much greater propensity to penetrate when confined without food. Many penetrations occurred within 24 h and most occurred with 1 wk. Some larvae that did not penetrate and subsequently transformed Into adults made more penetrations as adults than as larvae. The locations of the penetrations In the vertically positioned pouches were predominantly In the bottom half of the pouches and In a zone 0-1 cm from the folds. Descriptors: TRIBOLIUM-CASTANEUM CRYPTOLESTES-PUS ILLUS ORYZAEPHILUS-MERCATOR CATHARTUS-QUADRI COLL IS TENCBROIDES-MAUR- ITANICUS DERMESTES-MACULATUS TROGODERMA-VAR IABILE LAS IOOERMA- - SERRICORNE CORCYRA-CEPHALONICA EPHESTIA-CAUTELLA PLOD I A - I NTER- PUNCTELLA FOOD LARVA ADULT CELLOPHANE POLY ETHYLENE PAPER POLY VINYL CHLORIDE ALUMINUM FOIL POLY ESTER POLY PROPYLENE Concept Codes: BEHAVIOR BIOL-AN IMAL BCHAVI OR(*07003); NUTRITION-GENL.NUTR STATUS,METHS( 13202); NUTRITI ON-MALNUTRITI ON . OBESI TY ( 13203 ) ; DEVELOPMNTL BIOL-GENL,DESCR IPT1VE(25502); DEVELOPMNTL BIOL-GEN MORPHGENSIS(25508): ECONOM ENTOMOL-STORED PRODUCTS!*60008); ECONOM ENTOMOL-CHEM PHYS CONTRL(*60016): INVERTB PHYSIOL-INSECTA-PHYSIOL(64076) Blosystomat1c Codes: COLEOPTERA(75304 1 ; LEPIOOPTERA(75330) hydrocarbons (PAH) In smoko particulates obtained from pyrolysis and combustion of polyfvlnyl chloride) under simulated fire conditions. ,mu.-Silica and .mu.-Styrage 1 columns were used In high pressure liquid chromatography for PAH fraction Isolation. An Ultra-Bond column was used In gas chromatography (C.C) and GC/mass spectrometry for quantitation of individual PAH In the particulates. Many PAH were Identified, Including carcinogenic benzol aIpyrene and 7. 12-d1methyl-benz(a]anthracene. Descriptors: SIMULATED FIRE CONDITIONS BENZO A PYRENE 7 12 Dl METHYL BENZ A ANTHRACENE CARCINOGENS Concept Codes: ECOLOGY-BIOCLIMATOL.BIOMETEOROL(07504); BIOCHEM METH-GENERAL(* 10050); BIOCHEM STUD - GENERAL( 10060); BIOPHYS-GENERAL BIOPHYS TECH(* 10504); EXTERN EFF-HOT( 106 1 8 ) : MOVEMENT( 12 100); TOXI COL -ENVIRONMNTL. INDUSTR(*22506); TEMPERA TURE -GENL.METHSC23001): NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(2400- 7); ENVIRON HEALTH-AIR.WATR.SL POLLN(* 37015) 67031324 DETERMINATION OF POLY NUCLEAR AROMATIC HYDRO CARBONS IN POLY VINYL CHLORIDE SMOKE PARTICULATES BY HIGH PRESSURE LIQUID CHROMATOGRAPHY AND GAS CHROMATOGRAPHY MASS SPECTROMETRY LIAO d C: BROWNER R F SCH. CltEM., GA. INST. TECHNOL.. ATLANTA. GA. 30332. USA. ANAL CHEM 50 (12). 1978 1683-1686. Codon: ANCIIA Language: ENGLISH A simple, fast and accurate chromatograpn Ic method was n *1 t rV> M f: I T'yM f '* * * 4 * 1 " `1 ^ * - - 1 * 77-03/Jon BA7502;RRM2402(See F11e55) (c. BIOSIS 1982) (Item 472 of 858) User 3614 25Jan83 2 147 67029496 VINYL CHLORIDE AND VINYL BENZENE STYRENE METABOLISM MUTAGENICITY AND CARCINOGENICITY VAINIO H DEP`. IND. HYG. TOXICOL.. INST. OCCUP. HEALTH. HAARTMANINKATU 1. SF-00290 HELSINKI 29. FINL. CHEM-BIOL INTERACT `?2 (1). 1978 117-124. Coden: CBINA Language: ENGLISH Vinyl .chloride and vinyl benzene (styrene) are mutagenic In microbial tests, In Orosophlla. In yeast and In mammalian cells. Reports from various countries show an excess of chromosomal aberrations In the lymphocytes of workers exposed to vinyl chloride monomer when the workers are compared with controls. Workers occupationally exposed to styrene also reveal a clear increase In the rate of chromosome aberrations In their lymphocytes. Both chloroethylene oxide and styrene oxide, tho primary biotransformation products of vinyl chloride and styrene. respectively. bind covalently to cellular macromolecules. Vinyl chloride Is a carcinogen In both animals and man. Styrene Is currently being tested in animals. The demonstration of mutagenic response via microbial and other test systems and observations of significant excesses of chromosomal aberrations among workers exposed to these agents raise scientific and health concern about possible genetic risks of vinyl chloride an,d styrene to man. Descriptors: MICROBE DROSOPHILA YEAST MAMMAL CELL HUMAN LYMPHOCYTE CHLORO ETHYLENE OXIDE STYRENE OXIDE CARCINOGENS OCCUPATION Concept Codes: CYTOLOGY/CYTOCHEM-PLANT(02S04); CYTOLOGY/CYT- OCHEM-ANIMAL(02506); CYT0L0GY/CYT0CHEM-HUMAN(O25O8); GENETICS- /CYTOGENET-GENL STUDIES(*03502); GENET ICS/CYTOGENET-PLANT(035 - 04); GENETICS/CYT0GENET-ANIMAL(O35O6); GENETICS/CYTQGENET-HUM- AN(0350B); ' SOCIAL BIOL/HUMAN ECOLOGY(05500); BIOCMEM STUO-GENERAL(10060): BIOPHYS-MOIECUL PROP,MACROMOLEC(10506): ANATOMY/111 STOL - Ml CRO . ULTRAMICRSC( 11108); METAHOl I SM-C.ENL STUD- .METAB PATHW(13002); BLOOD/BODY FLDS-B100D CELL STUDS(15004); BLOOD/BOUY F LOS-LYMPHAT TISS.RES(15000); ROUTES OT IMMUNIZ.INFECT.THERAP(22100); TOXI COL-GENL/EXP STUDS.MET IIS(* 2 - 2501); TOXI COL -ENVIRONMNTL,INDUST R ( * 22 506); NEOPLSMS/NCQPL AGNTS -B I OCI IE M ( *24006) ; NEOPLSMS/NEOPL AGNT S-C ARC I NOC.ENS ( *2400- 7); BAC T ERI A-PHY$IOLOGY,BIQCHEMISIRY(3lOOO); BACTERIAL AND VIRAL GENETICS(*31500); MICROBIOLOG APPARAT.METHS.MED I A(32000) ; ENVIRON HEAL1H-0CCUPATNL HEALTII ( * 370 13); PLANT PI IYSIOL-CHEM CONSTITUENTS! 5 1522 ) : INVERTB PI IYS 101. - INSECT A - PATHOL ( *64070) Blosystomnt1c Codes: MICROORGANISMS-UNSPECIFIEO(O1O00); FUNGI-UNSPECI F I ED ( 15000) : DI PT ERA ( 753 1*1) ; MAMMAL I A-UNSPEC I F I ED AND E XT INCT(85700); HOMINI DAE(86215) (1). trIch1oroethy1ene oxide (2), teteach 1oroethy1ene oxide (3), cis- and trans- 1-ch1oropropene oxide (4 and 5). and cls- and trans-1.3-dI chioropropene oxide (6 and 7). were synthesized from their respective chIoroaIkenes via either autooxygenation (In the case of 2 and 3) or m-chloroperbenzo Ic acid oxidation (In the case of 1 and 4-7). Dichlorobenzene was a byproduct In the synthesis of both 6 and 7. In tho case of 6. Its formation was determined to be a result of a blmolecular reaction Involving an Intermediate In the synthesis of 6. Kinetics of hydrolysis at pH 7.-1 and 37.degree. C were determined for compounds 2-7. Kinetics of thermal decomposition in dilute hydrocarbon solution were determined for compounds 2. 4, 5. and 7, The hydrolysis and thermolysis rates are discussed with respect to structure and mechanism of product formation. Descriptors: VINYL CHL0RI0E OXIDE TRI CHLORO ETHYLENE OXIDE 1 CHLORO PROPENE OXIDE 1 3 01 CHLORO PROPENE OXIDE CARCINOGENS AUTO OXYGENATION M CHLORO PER BENZOIC-ACID OXIDATION 01 CHLORO BENZENE KINETIC STUDIES HYDROLYSIS THERMAL DECOMPOSITION Concept Codes: BIOCHEM METH-GENERAL( 10050) ; BIOCHEM STUO-GENERAL(10060): BIOPHYS-MOLECUL PROP,MACROMOLEC(10506); EXTERN EFF-HOT( 106 18); TOXICOL-GENL/EXP STUDS,METl IS(*22501); TEMPERATURE-GENL.METHS(23001): NEOPLSMS/NEOPL AGNTS-CARC INOGE- NS( *2*1007 ) B losystemat 1c Codes: CHORDATA-UNSPECIFIED(85000) 67029-147 SYNTHESIS AND REACTIONS OF CHLORO ALKENE EPOXIDES KLINE S A; SOLOMON J d; VAN DUUREN B L LAB ORG. CHEM. CARCINOG., INST. ENVIRON. MEO.. N.Y. MED. CENT.. NEW YORK. N.Y. 10016. USA. J ORG CHEM 43 (18). 1978 3596-3600. Coden: JOCEA Language: ENGLISH Thn ( MnrmM I r* rMnufinll/ofif nhhv I Hna i r f *-4i i t * 1 n Ipii UNIV. mu DIAL0GTl1e5: BI R&S 138502 BA7502;RRM2402(See Ftle55) (c. BIOSIS 1982) (Item 474 of 858) User 3614 25Jan83 2 148 67026 t 4 0 INTERACTION OF PLASMA PROTEINS WITH ARTIFICIAL SURFACES PROTEIN ADSORPTION ISOTHERMS CHUANG H Y K: KING W F; MASON R G DEP. PATHOL., UNIV. S. FLA. COLL. MED., TAMPA. FLA. 33612, USA. 12901 N. 30TU ST.. J LAB CLIN MED 92 (3). 1978 483-496. Coden: ULCMA Language: ENGLISH A simple technique using a small disc which Is dipped Into a 1251-labeled protein solution was devised to study the adsorption of human albumin, fibrinogen and Ig(immunoglobul1n]G onto Cuprophane or PVC [polyvinylchloride- ). The purity of these human plasma proteins was examined carefully with polyacrylamide gel electrophoresis and Immunochemical methods. The adsorption Isotherms of albumin, fibrinogen and IgG show a Langmuir type adsorption. Deltptdatlon of albumin did not alter the albumin affinity to Cuprophane and PVC. The surface saturation concentration (ng/cm2) for albumin, fibrinogen. or IgG were all more on PVC (a hydrophobic surface) thah on Cuprophane (a hydrophilic surface). The competitive adsorption of I protein species In 2- or 3-proteln mixture was also studied. Albumin and fibrinogen compete with each other for adsorption. The effects of IgG on the adsorption of albumin or fibrinogen were Inconsistent and not predictable; the reason for this Is unknown. The effect of laminar flow on albumin adsorption was studied with a specially designed Richardson flow chamber. In general. flow caused an Increase In albumin adsorption over that at static conditions. The Increase of albumin adsorption was more pronounced also for PVC than for Cuprophane from 1-10 ml/mln. Descriptors: ALBUMIN 1MMUN0 GLOBULIN G FIBRINOGEN HUMAN CUPROPHANE POLY VINYL CHLORIDE GEL ELECTROPHORESIS IMMUNOCHEMICAL STUDIES RICHARDSON FLOW CHAMBER Concept Codes: RADIATION BIOL-RADTN.ISOTOP TECH(06504): BIOCHEM STUD-GENERAL( 10060): BIOCHEM STUD-PROTE1 NS,PEPTIDES.A - MINO ACD(*10064); BIOPHYS-GENERAL BIOPHYS TECH( 10504); BIOPHYS-BIOENGINE ERING(*10511); MOVEMENT(12 100); BLOOD/BODY FLDS-BLOOD,LYMPH STUD(*15002); IMMUNOL/IMMUNOCIIEM-GEN METH(34 502 ) BlosystematIc Codes: HOMINIDAE(062 15 ) 67023197 10 CASES OF ANGIO SARCOMA OF THE LIVER IN SHAWINIGAN QUEBEC CANADA DELORME F: THERIAULT G DEP. PATHOL., CENT. HOSP. REG. MAURICE. SHAWINIGAN. OUE.. CAN. J OCCUP MED' 20 (5). 197B 338-340. Coden: JOCMA Language: ENGLISH Ten cases of angiosarcoma of the liver have been diagnosed In Shawlnlgan. Quebec [Canada) since 1955. All have occurred In men who worked In a vinyl chloride polymerizing plant. Cigarettes and alcohol did not seem to be associated with this tumor. The amount of vinyl chloride to which these people wero exposed. according to Information obtained through questionnaires. appears elevated. Angiosarcoma of the liver was accompanied by a fibrosis or the liver which may precede Its appearance. In describing the Canadian cases of angiosarcoma, this study attempted to shed more light upon the causal relationship between vinyl chloride monomer and angiosarcoma or the liver and to provide some clues to understanding the pathogenesis of this disease. Descriptors: HUMAN VINYL CHLORIDE CIGARETTES ALCOHOL LIVER FIBROSIS Concept Codes: SOCIAL BIOL/HUMAN ECOLOGY(05500); BEHAVIOR BIOL -HUMAN BEIHAVIOR(07004); BIOCHEM STUD-GENERAL( 10060); DIGESTIVE SYST-PATHOLOGY(* t 4006); CAROIOVASC SYST-BLD VESS PATHOL(* 14508); PSYCHI ATRY-ADD ICT10N(1NC SMOKNG)(21004); TOXICOL-GENL/EXP STUDS.METHS(22501); TOXI COL -ENVIRONMNTL,INDU- STR(*22506 ) ; NEOPLSMS/NEOPL AGNTS-PATM.CL INIC(* 24004); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(*24007); ENVIRON HEALTH-OCCU- PATNL HEALTU(*37013); ENVIRON HEALTH-A IR.WATR.5L POLLN(370 1 5); EPIDEMIOL-ORGANIC 015.NEOPLASMS!*37054 ); PLANT PI IYSIOL-CHEM CONST ITUENT S(51522); AGRONOMY-TOBACCO CR0PS(525I2) Blosystematlc Codes: SOLANACEAE(26775 ) : HOMINIOAE(86215 ) 67023193 10 CANADIAN CASES OF ANGIO SARCOMA OF THE LIVER IN VINYL CHLORIDE WORKERS DELORME F CENT. HOSP. REG. MAURICIE, CP 1130. SHAW INI GAN-SUD. OUE.. CAN. ANN ANAT PATHOL 23 (2). 1978 97-104. Coden: ANAPA Language: FRENCH Ten cases of angiosarcoma of the liver among vinyl chloride workers from a plant In Shawlnlgan, Quebec [Canada) are reported. The occupational history of these workers and morphologic description of the lesions were presented. pathogenic hypothesis Is submitted. A Descriptors: HUMAN CARCINOGEN Concept Codes: SOCIAL BIOL/HUMAN ECOLOGY(05500): BIOCHEM METH-GENERAL( 10050); BIOCHEM STUD-GENERAL( 10060); ANATOMY/HIS- TOL-MICRO.ULTRAMICRSC(11108); DIGESTIVE SYST-PATHOLOGY(*14006) ; CARD I OVA SC SYST-BLD VESS PATHOL( * 14508) ; BONE.JNTS.FASC.CON- N/AD1P-PAT1I0L( 18006): TOXI COL-ENVIRONMNTL.INDUSTR(*22506): NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007); ENVIRON IIEALTH-OCCU- PATNL HEALTH!*37013) B losystemat1c Codes: HOMINIDAE(86215) R&S 138503 DIALOG FlleS: BIOSIS Previews... UJ,uan BA7502;RRM24Q2(See F11eS5) (c. BIOSIS 1982) (Item 477 of 858) User 3614 25jan83 2 149 67023 192 ASSOCIATION OF ANGIO SARCOMA OF THE LIVER WITH HEPATOMA IN A VINYL CHLORIDE WORKER DELORME F CENT. HOSP. REG. MAURICIE, CP 1130. SHAW1NI GAN-SLID. OUE. . CAN. ANN ANAT PATHOL 23 (2). 1978 105-113. Coden: ANAPA Language: FRENCH This report deals with a 51 yr-old man who, for 23 yr and 4 mo. of his working life, was exposed to vinyl chloride vapors. Autopsy revealed a hepatoma associated with an angiosarcoma of the 1tver. The case Is the 1st ever to be reported In the medical lltterature. This case raises doubts about the theory which suggests that the carcinogenic effect of vinyl chloride In man elicit a tumor of vascular nature. .Descriptors: HUMAN CARCINOGEN Concept Codes: SOCIAL BIOL/HUMAN ECOLOGY(05500): BIOCHEM METH-GENERALl 10050): B1OCHEM STUD-GENERAL( 10060); PATHOLOGY-N ECROSIS ( 1 25 10 ) : DIGESTIVE SYST-PATH0L0GY(* 14006); CARDIOVASC SYST-BLD VESS PATHOL(*14508); BONE,JNTS.FASC.CONN/AD IP-PATHOL - (18006); TOXICOL-ENVIRONMNTL.INOUSTR(*22506); NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007): ENVIRON HEALTH-OCCUPATNL HEALTH(* 3 - 7013 ) Blosystemat1c Codes: HOMINIDAE(B6215) 67021626 . 1ST STAGES OF MICROBIAL DEGRADATION OF POLY VINYL CHLORIDE STEREO SCAN ELECTRON MICROSCOPICAL INVESTIGATION KILBERTUS G LAB. MICROBIOL.. CENT. 2 CYCLE CO 140. UNIV. NANCY I. 54037 NANCY CEOEX'. FR. MATER ORG (BERL) Language: FRENCH 13 (2). 1978 89-100. Codon: MTOGA The development of the surface microflora was observed with SEM (stereoscan electron microscopy] during successive stages In the alteration of PVC [polyvinylchloride]. When decomposing In nature, this material exhibits a scarce fungal and bacterial population. This scarcity Is probably related to the toxicity of this material. Descriptors: BACTERIA FUNGI Concept Codes: ELECTRON MICROSCOPY(01058): BIOCHEM STUD-GENERAL( 10060); METABOLISM-GENL STUD.METAB PATHW(* 13002); TOXICOL-C.ENL/EXP STUDS .ME THS( *22501 ) : B AC TER I A -PIIYS I OLOGY , BIO CHEM ISTRY(* 31000): MICROBIOLOG APPARAT,METI IS.MEOI A(32000); FOOD/INDUS MICRO-BIODEGRAD.DETER(*39006) Blosystemat1c Codes: BACTERI A-UNSPECIFIEO(04000); FUNGI-UNS- PECIF I EOI 15000) SAVANNAH, GA. 31403, USA. U ECON ENTOMOL 71 (4). 1978 689-G91. Language: ENGLISH Coden: JEENA Larvae of the lepldopteran species Ephestla cautolla (Walker), Corcyra cephalonlca (Stalnton) and Plodia 1nterpuncte11 a (Huebner) clung to and climbed paper. glass, aluminum foil, cellophane, polyethylene (PE). fluorlnated ethyIenepropy1ene (FEP), ethy1enetetraf1uoroethy 1ene (ETFE). polyester (PET), polyvinylchloride (PVC) and polypropylene (PP) at the greatest angle of Incline (90.degree.). Larvae of 8 coleopteran species only climbed paper at 90.degree.. Larvae of some species could not climb some materials at a 5.degree. Incline. Coleopteran larvae ranked generally from best to worst climbers were Anthrenus flavlpes LeConte, Dermestes maculatus De Geer. Trlbollum castaneum (Herbst), Oryiaephllus mercator (Fauvel), Cathartus quadrlcollls (Guer1n-Menev111e ) . Trogoderma varlablle Ball Ion, Attagenus megatoma (F.) and Lasloderma serrlcorne (F. ) , Test materials ranked from easiest to most difficult to climb were paper, ETFE. PET, foil, cellophane, PE, FEP. glass, PVC and PP. Three coleopteran species. 0. mercator. C. quadrlcollls and D. maculatus clung to all materials at 90.degree.. Other larvae ranked from best to worst dingers were T. varlablle, Trlbollum castaneum, Anthrenus flavlpes, Attagenus megatoma and L. serrlcorne. Tost materials ranked generally from easiest to most difficult to cling to were paper, glass, PET, ETFE. PVC. cellophane, FEP. foil, PE and PP. Descriptors: EPHESTIA-CAUTELLA CORCYRA-CEPHALONICA PL0DIA-I: NTERPUNCTELLA ANTHRENUS-FLAVIPES DERMESTES-MACULATUS TRIBOLIU- M-CA5T ANEUM ORYZAEPHILUS-MERCATOR CATHARTUS-OUADRICOLL I S TROGODERMA-VARIABILE ATTAGENUS-MEGATOMA LASI0DERMA-SERRICORNE PAPER GLASS ALUMINUM FOIL CELLOPHANE POLY ETHYLENE FLUORINATEO ETHYLENE PROPYLENE ETHYLENE TETRA FLUORO ETHYLENE POLY ESTER POLY VINYL CHLORIDE POLY PROPYLENE Concept Codes: BEHAVIOR BIOL-ANIMAL BEHAVI OR( * 07003); MOVEMENT! 12100): FOOD TECU-PREP.PROCESSNG.STORAGE(*13532 ) : DEVELOPMNTL BIOL-GENL,DESCR IPTIVE(25502 ); ECONOM ENTOMOL-STOR- ED PRODUCTS!*60008); INVERTS PHYSIOL-INSECTA-PHYSIOL(6407 6) BtosystematIc Codes: COLEOPTERA(75304); LEPIDOPTERA(75330) 67021194 CLINGING AND CLIMBING ABILITY OF LARVAE OF 11 SPECIES OF STORED PRODUCT INSECTS ON 9 FLEXIBLE PACKAGING MATERIALS AND GLASS CLINE L D c* fnnrn . ftrtf'P* Hir r n T P hf P r* r * / rt DIAL0G^n1e5: BIOSIS Preview: R&S 138504 02(See FI 1 e55) (c. BIOSIS 1982) (Item 480 of 858) User 3614 25Jan83 2 150 670191 13 PESTICIDE INDUCED CHANGES IN HEPATIC MICROSOMAL ENZYME SYSTEMS FURTHER STUDIES ON THE EFFECTS OF 1 1 DI-P CHL0R0PHENYL-2-CHL0R0 ETHYLENE IN THE JAPANESE QUAIL STANLEY P I; BUNYAN P J; REES W D; SWINDON D M; WESTLAKE G E PEST INFEST. CONTROL LAB.. MINIST. AGRIC. FISH. FOOD. TOLWORTH, SURBITON. SURREY. ENGL., UK. CHEM-BIOL INTERACT Language:' ENGLISH 21 (2-3). 1978 203-214. Coden: CBINA Changes In the liver' resulting from the low level dietary administration of 1 , 1 ~d1(p-ch1oropheny1 ) -2-ch1oroethy 1ene (DOMU),p,p*-DDT . o,p'-DDT,p,p'-DDD and p,p'-DDE to Japanese quail were monitored. DDMU was exceptional In causing substantial Increases In relative liver weight and hepatic glucose-6-phosphatase after feeding at 100 ppm for 2B days. The time course of liver enzyme Induction by DDMU was studied In Japanese quail after periods of dietary administration ranging from 1-28 days with particular reference to changos In hepatic cytochrome P-450 and relative liver weight. Structural changes In the 1Iver were followed by reference to protein and lipid components. The hepatic response to DDMU appears to be blphaslc. Initially there are substantial Increases In hepatic cytochromo P-450 and relative liver wolght. but tho latter Is largely due to accumulation of tr1g1ycor1des. After approximately 20 days the level of .hepatic tr1g1ycerIdes returns to normal. but the relative liver weight and hepatic cytochrome P-4S0 remain at a high plateau level. This secondary phase of liver Induction probably Involves cell prol1feration. DDMU causes major changes In the avian liver and either directly or through a metabolite causes pronounced microsomal enzyme Induction. Descriptors: DDT DDE DDD INSECTICIDES GLUCOSE 6 PHOSPHATASE CYTOCHROME P-4S0 PROTEIN LIPID Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506); BIOCHEM STUD-GENERAL( 10060); BIOCHEM STUD-PROTEI NS.PEPTIDE5.AM I NO ACD( 10064); BIOCHEM STUD-PORPHYRNS.BILE PIGM( 10065); BIOCHEM STUD-LIPIDS( 10066); ENZYMES-GEN,COMPAR STUD.COENZYMS(* 10802); ENZYMES-PHYSIOLOGICAL STUD IES(10808); PHYSIOLOGY-GENERAL STUDIES(12002); METABOLISM-LIPIDS(13006); METABOLISM-PROTNS,P- EPTDS.AM ACOS( 13012); NUTRITI ON-GENL.NUTR STATUS.METIIS(* 13202) ; NUTRITION-PATHOGENIC DIETS( 1 3216 ) ; DIGESTIVE SYST-ANATOMY( I - 4002); DIGESTIVE SYST-PATHOLOGY(14006); TOXI COL-GENL/EXP STUDS.METHS(*22501 ): TOXI COL-ENVIRONMNTL.INDUSTR(22506); PEST CONTRL GENL/PESTICS/HERBICS(*54600); ECONOM ENTOMOL-CHEM PHYS CONTRL(60016) Blosystemat1c Codes; GALLIF0RME5(85536); ABSTRACTS OF ENTOMOLOGY(96000) (CBA/H .times. CBA/H-T6)F1 mice were given s.c. Implants of unplastlclzed vinyl chloride acetate 15 .times. 22 mm copolymer films. The animals were pulsed with (311 ]thymId 1ne at various times during the 15 mo. following Implantation. ONA synthesis occurred In the film-attached cell population, predominantly macrophages. throughout the preneoplastic phase In females and males. Giant cells with fewer than 10 nuclei were labeled synchronous Iy and asynchronous 1y. No ONA synthesis was detected In giant cells with -more than 10 nuclei. Previous studies showed that phagocytic Inactivity and u1trastrueturaI signs of functional dormancy are character 1s11c for the foreign body-reactive macrophage. The macrophage was not dormant with respect to DNA synthesis. Descriptors: VINYL CHLORIDE ACETATE FILM IMPLANTATION CARCINOGEN TRITIATED THYMIDINE LABELING MACROPHAGES Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506); GENET ICS/CY- TOGENET-ANJ MAL(03506); RAD IATI ON BIOL-RADTN. ISOTOP TECH(065O4) ; BIOCHEM STUD-GENERAL(10060): BIOCHEM STUD-NUCL ACD.PURNS * PYRM( 100G2); BIOPHYS-MOLECUL PROP.MACROMOLEC( 10506): EXTERN EFF-PHYSICAL.MECH EFFECTS( 10612); ANATOMY/HISTOL-REGE - N,TRANSPLANT ( 11107); ANATOMY/HISTOL-MICRO.ULTRAMICRSC( 11108); ME T ABOLISM-NUCL ACD,PUR INS.PYRIM(13014); BLOOO/BODY FLDS-BLQ- OD CELL $TUDS(15004); BLOOD/BODY FLDS-LYMPHAT TI55.RES( * 15000); INTEGUMENT SYST-GENL STUDS,METIIS( 1B50 I ) ; ROUTES OF IMMUNIZ.INFECT.THERAP(22100); TOXICOL-GENL/EXP STUDS.METHS(*22501); NEOPLSMS/NEOPL AGNTS-IMMUNOLOGY(24003); NEOPLSMS/NEOPL AGNTS-BIOCHEM(*24006); NEOPLSMS/NEOPL AGNTS-CA- RCI NOGENS(*24007); IMMUNQL/IMMUNOCHEM-IMMUNOPATHOL(34508) Blosystemat1c Codes: MUR I DAE(8637 5 ) 67016728 FOREIGN BODY TUMORIGENESIS IN MICE DNA SYNTHESIS IN SURFACE ATTACHED CELLS DURING PRE NEOPLASIA THOMASSEN M J; BUOEN L C; BRAND I; BRAND K G DEP. PEDIATR.. CASE WEST. RESERVE UNIV., CLEVELAND. OHIO ` 44106. USA. J NATL CANCER INST 61 (2). 1978 359-364. Codon; JNC1A Language: ENGLISH dialog' ri e5 : BIOSIS Previews 77-83/. R&S 138505 I le55 (c. BIOSIS 1982) (Item 482 of 858) User 3614 2SJan83 2 15 1 67014795 STUDIES ON THE ECOLOGY OF BLACK FLIES SIMIJLIIDAE DIPTERA PART 1 COMPARISON OF SOME QUANTITATIVE SAMPLING METHODS FOR LARVAE NAKAMURA Y; SAITO K; TAKAHASHI M YOKOHAMA CITY INST, HEALTH. TAKIGASHIRA. ISOGO, YOKOHAMA 235. JPN. UPN J SANIT ZOOL 29 (2). 1978 209-212. Language: JAPANESE Coden: ESDBA Artificial substrates for Immature slmulllds were compared to establish a standard quantitative sampling method. Hand collection methods were also Investigated. Artificial substrates used were nylon scrubbing brushes. short and long polyvinyl chloride (PVC) sheets. PVC tubes. fire bricks, normal bricks and ceramic tiles. Number of slmulllds captured by the PVC tubes was largest and that by the nylon scrubbing brushes was smallest. Hand collections were carried out by 2 collectors for 5 min each. To collect the Immature stages of slmultld quantitatively, use of 2 methods, PVC tubes and 5 min hand collection are recommended. Descriptors: POLY VINYL CHLORIDE TUBES HAND COLLECTION Concept Codes: GENERAL FIELD METHODS(01008): GENERAL FIELD APPARATUS(OIOIO); MATHEMATIC BIOL/STATISTIC METHC04500): BEHAVIOR BIOL-ANIMAL BEHAVI0R(*07003); ECOLOGY-ANIMAL(*07508); ECONOM ENTOMOL-ANIMAL PESTS(*60012): ANIMAL DISTRIBUTION/ZOOG EOGRAPHY (62800): INVERTS TAXN-INSECTA.01PTERA{* 63574 ) Blosystemat1c Codes: DIPTERA(753 14 ) WEST P W; REISZNER K D DCP. CIIEM., ENVIRON. SCI. INST., LA. STATE UNIV.. BATON ROUGE. LA. 70803. USA. AM IND HYG ASSOC J 39 (8). 1978 645-650. Coden: AIHAA Language: ENGLISH A passive dosImeter-type personal monitor for vinyl chloride underwent extensive field testing. Collaborative studies by a number of laboratories confirm the accuracy. reliability, convenience and general acceptability of personal monitors utilizing gas permeation for sample collection and quantification. Data are generated as tlmewelghted averages and response is linear from 5 ppb-50 ppm. The monitors, which weigh only 35 g. are unaffected by variations In environmental cond1tIons. Concept Codes: BIOCHEM-GASES( 10012): BIOCHEM METH-GENERAL(* - 10050): BIOCHEM SriJD-GENERAL( 10060): BIOPHYS-BIOENGINEER1NG(* - 10511); TOXICOL-ENVIRONMNTL.INDUSTR(*22506); ENVIRON MEALTH-0- CCUPATNL HEALTH!37013); ENVIRON HEALTH-A IR.WATR.SL POLLN(*37015) 67012826 URETHRAL REACTION TO CATHETER MATERIALS IN DOGS ENGELBART.R H; BARTONE F F; GARDNER P; HUTSON J DEP. UROL., CDLL. MED., UNIV. NEBR.. 42ND ST, AND DEWEY AVE.. OMAHA, NEBR. 68105, USA. INVEST UROL 16 (1). 1978 55-56. Coden: INURA Language: ENGLISH The reaction of the dog urethra to 2 new polyurethane polymers was compared with those produced by materials currently used In the manufacture of urethral catheters. The comparison Included sill cane, latex rubber, tetraf1uoroethy Ie- ne polymer (Teflon) coated latex and polyvinyl chloride. There were no significant differences in the reaction of the urethra to the various materials. The present study was carried out In the absence of bacterial contamination. Descriptors: SILICONE LATEX RUBBER TETRA FLUORO ETHYLENE POLYMER COATED LATEX POLY VINYL CHLORIDE Concept Codes: BIOCHEM STUD-GENERAL( 10060): BIOPHYS-BIOENGI NEER ING(* 105 1 1 ) ; ANATOMY/HISTOL-EXPERI MENTAL( 1 I 104); URIN SYST/EXT SECR-GEN STUD,METH(* 15501 ): URIN SY5T/EXT SECR-ANATOMY(15502); URIN SYST/EXT SECR-PMYSL.U1UCHEM(*t5504) BlosystematIc Codes: CANIDAE(85765) 67012073 FIELD TESTS OF A PERMEATION TYPE PERSONAL MONITOR FOR VINYL CHLORIDE/ m DIALOG e5: BIOSIS Previews 77-83/Jan BA7502 R&S 1385 G7010216 RAT LIVER MICROSOMAL UPTAKE AND IRREVERSIBLE PROTEIN BINDING OF 1 2 CARBON-14 VINYL BROMIDE BOLT H M: FILSER J G; HINDERER R K INST. TOXICOL.. UNIV. TUEBIN.GEN 1. W. GER. TUEB., W!LHELMSTR, 56. D-7400 TOXICOL APPL PHARMACOL TXAPA 44 (3). 1978 481-490. Coden: Language: ENGLISH When rat liver mlcrosomes are Incubated In a [14C]vlny1 bromide atmosphere, rapid equilibration of vinyl bromide occurs between the gas and liquid Incubation phases. The presence of NADPH In the Incubation further Increases the uptake of radioactivity Into the Incubation mixture which Is related to microsomal metabolism of vinyl bromide. Saturation of metabolizing enzymes occurs at a partial pressure of vinyl bromldo In the gas phase of 0.1 Torr. which Is about 1 order of magnitude less than previously reported for the carcinogen vinyl chloride. The presence of 1,2.3-benzoth1 adiazo1e derivatives and SKF 525 A ' [2-d1ethy I am InoothyI - 2.2-dIpheny1 valerate] Inhibits microsomal metabolism of vinyl bromide. Part of the vinyl bromide metabolites bind Irreversibly to microsomal protein. Irreversible binding depends on NADPH. with the Vmax amounting to 6.6 pmol bound/mg of microsomal proteln/mln. Half-maximal binding occurs at a partial pressure of vinyl bromide in the gas phase of 0.022 Torr. If soluble proteins are added to the microsomal Incubation, vinyl bromide metabolites also Irreversibly bind to those proteins. Strain differences occur In metabolism of vinyl bromide by liver mlcrosomes from Sprague-Dawley and Wlstar rats. Descriptors: VINYL CHLORIDE CARCINOGENS 1 2 3 BENZOTHIADIAZOLE 2 DI ETHYLAMI NOETHVL-2 2-DIPHENYL VALERATE SKF-525-A METABOLIC-DRUG NADPH Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506); RADIATION BIOL-RADTN,ISOTOP TECH(06504); COMPARATIVE BIOCHEM-GENL STUDIES!100lO); BIOCHEM-GASES(10O12); BIOCHEM STUD-GENERAL(IQ- 060); EXTERN EFF-PRESSURE(10606); PHYSIOLDGY-COMPARAT1VE(1200- 3): METABOLISM-GENL STUD.METAB PATHW(* 13002); METABOLISM-PROT- NS,PEPTDS,AM ACDS(* 13012): DIGESTIVE SYST-PHYSIOL.B10CHEM(*14 - 004): PI IARMAC0L - DRUG METAB. METAB ST I MU ( * 22003 ) : TOX J COL-C.ENL/- EXP STUDS.METFIS(*22501 ): NEOPLSMS/NEOPL AGNTS-BIOCHEM(* 24006); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(*24007); LABORATORY ANIMAL S- - GENL STUDS(28002); IN VITRO STUDS-CELLULR.SUBCELL(32600) BtosystcmatIc Codes: MUR I DAE(86375) BIOSIS 19B2) (Item 485 Of B58) User 3G14 25Jan83 2 152 to determine If VC-Induced care I nogenes 1s may be rotated to electrophilic alkylation of macromolecules In vivo. Male Sprague-Dawlny rats were exposed to 1. 10. 25, 50, 100. 250. 500 or 5000 ppm of [I4C]VC for 6 h. Following exposure, radioactivity covalently bound to hepatic macromolecules and purified nucleic acids (RNA, DNA) was determined. The total amount of [14C]VC metabolized and hepatic glutathione (GSH) content were also determined. The total amount of rad 1oact1v1ty bound to macromo1 ecu 1es In the liver did not Increase proportlonately to the Increase In the exposure concentra11 on of VC, A dIsproportIonate decrease In macromolecu I or binding was observed as the concentration of VC Increased. Covalent binding to hepatic macromolecules was related to the amount of VC metabolized. At exposures greater than 50 ppm, the amount of 14C bound to macromo1 ecu 1es In the liver- correlates with Induction of hepatic angiosarcoma. There was no detectable binding of radioactivity to DNA or RNA In the liver. Hepatic glutathione content was significantly depressed only at exposure concentrations greater than 100 ppm. Descriptors: RAT CARCINOGEN ANGIO SARCOMA RNA DNA BINDING GLUTATHIONE CONTENT Concept Codes: RADIATION BIOL-RADTN.ISOTOP TECH(0G504); BIOCHEM METH-GENERAL( 10050): BIOCHEM METH-NUCL ACD.BURNS.PYRM- (10052): BIOCHEM METH-PROTNS.PEPTDS.AM AC(10054): BIOCHEM STUD-GENERAL(10060): BIOCHEM STUD-NUCL ACD.PURNS.PYRM(10062): BIOCHEM STUD-PRDTEINS.PEPTIDES,AMINO ACD( 10064): BIOPHYS-MOLE- CUL PROP.MACR0M0LEC(10506); METABOLISM-GENL STUD.METAB PATHW(* 13002); METAB0LI5M-PR0TNS.PEPTDS.AM ACDS(13012): METABOLISM-NUCL ACD.PUR I NS,PYRIM(* 13014): DIGESTIVE SYST-PATH- 0L0GY(* 14006); CARDIOVASC SYST-BLD VESS PATHOL(*14508): BONE,JNTS.FASC.CONN/ADIP-PATHOL(18006): TOXI COL-GENL/EXP STUO- S.METHS(*22501): NEOPLSMS/NEOPL AGNTS-BIOCHEM(*24006); NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007) Blosystemat Ic Codes: MUR I DAE(86375 ) 67010215 HEPATIC MACRO MOLECULAR BINDING FOLLOWING EXPOSURE TO VINYL CHLORIDE WATANABE P G; ZEMPEL J A; PEGG 0 G; GEHRING P J TOX1 COL. CHEM. CO. . TOXICOL TXAPA RES. LAB.. HEALTH ENVIRON. MIDLAND. MICH. 48640. USA. APPL PHARMACOL 44 (3), RES. . 1978 1B03 BUILD. . DOW 571-580. Coden: Language ENGLISH Covalent binding of radioactivity to hepatic macromo1 ecu 1 os In rats oxnosed to 14C-laboled vlnvl chlorine (Vf: 1 was atuHton DIALOG 1 e5: BIOSIS Previews 77-B3/dan BA7502;RRM2402( R 138507 1982) (Item 487 of 858) User 3614 25Jan83 2153 670 102 13 RESOLUTION OF DOSE RESPONSE TOXICITY DATA FOR CHEMICALS REQUIRING METABOLIC ACTIVATION EXAMPLE VINYL CHLORIDE GEHRING P J; WATANABE P G; PARK C N HEALTH ENVIRON. RES.. DOW CHEM.. USA, MIDLAND. MICH. 48640, USA . TOXICOL APPL PHARMACOL 44 (3). 1978 501-592. Codon: TXAPA Language: ENGLISH The toxicity of many chemicals results from blotransform.it ion products formed from chemical rather than the chemical per se. In such cases. the Incremental response may become d1m1n1shIng1y smaller with Increasing dose or exposure because activation of the chemical to the toxic form follows apparent MIchae11s-Menten rather than apparent Ist-order kinetics. Rats were exposed to concentratI oris ranging from 1.4-4600 ppm of vinyl chloride for 6 h. and the total amount metabolized was determined. The amount metabolized followed apparent MIchaeI Is-Menten kinetics. For rats, the logarithmic probability Incidence of angiosarcoma vs. the amount of vinyl chloride metabolized rather than the exposure concentration of vinyl chloride Is linear. Assuming no threshold In spite of evidence to the contrary, extrapolation of data below the range of doses causing experimentally observable responses predicted an Incidence of 0.01% hepatic angiosarcoma In rats exposed to 4.6 ppm of vinyl chloride. Theoretical extension of the extrapolation to humans after adjusting for metabolic and body mass differences was undertaken. The theoretical extrapolation for man exposed dally for 8 h to 1 ppm suggests an Incidence of 1.5/100.000.000- This theoretical incidence, although a likely overestimate because of a less than predicted Incidence In men exposed to' 200 ppm and greater, as well as'evldence for a threshold In rats, Is less than that expected to occur spontaneously. The concepts evolved from this analysis reveals why pharmacokinetics must be considered In deslgnlhg toxicology experiments as well as InterpretatIon of resulting data. Descriptors: RAT HUMAN CARCINOGEN LIVER ANGIO SARCOMA OCCUPATIONAL EXPOSURE Concept Codes: MATHEMATIC BIOL/STATISTIC METH(O450O): SOCIAL BIOL/HUMAN ECOLOGY(05500); BIOCHEM STUD-GENERAL( 10060); METABOLISM-GENL STUD.METAB PATHW(* 13002); DIGESTIVE SYST -PATHOLOGY(* 14 006); CARDIOVASC SYST-BLD VESS PATII0L(* 1450- 8): BONE.UNTS.FASC,CONN/AD IP-PATHOL( 18006); ROUTES OF IMMUNIZ.INFECT,THERAP(22 100) : TOXI COL-GENL/EXP STUDS.ME 11 IS(* 2 - 2501); TOX1 COL -ENVIRONMNT L,INOUSTR(* 22506): NEOPLSMS/NLOPL AGNTS-BIOCHEM( *24006): NEOPLSMS/NEOPL AGNTS-CARC I NOGENS(*2400- 7): ENVIRON HEALTH-OCCUPATNL HEALTH(* 37013) Olosystem.il Ic Codes: II0MINI DAE ( 862 15 ) : MUR IDAF. ( 86376 ) LAB. PATIIOl... NATL. CANCER INST.. ROOM 2A77 , BUILO. 10. BETHESDA. MO. 20014. USA. AM J PATIIOL 92 (2). 1978 349-376. Coden: AJPAA Language: ENGLISH Examples of human angiosarcoma following exposure to vinyl chloride. Thorotrast or As (medicinal and industrial) and cases. Including children, of unknown etiology were studied to establish diagnostic criteria and to study their evolution. The uniform evolution suggests an environmental factor also In the cases of unknown etiology. which may be established by epidemiologic studies. A precursor stage Is characterized by areas of combined Hyperplasia of hepatocytes and a variety of sinusoidal and per Is1nuso1 da 1 cells associated with excess of retlcutln and sinusoidal dilatation. The diagnostically useful picture In Ag Impregnations Indicates reticulum formation by the per 1 s I nuso1 da 1 cells. presumably the lipocytes. The hepatocytlc pro I 1feratI on suggests a hepatocarcI nogen Ic but usually not fully expressed potential. The mixed hyperplasia of the various sinusoidal colls proceeds to an overgrowth of angiosarcoma cells, presumably derived from endothelial cells. In early stages they are usually In contact with hepatocytes (Intralobular growth). A trabecular arrangement results from loosening of the lobular plate arrangement by dilatation of sinusoids, leading to primary pellosls. With disappearance of the hepatocytes, various growth patterns develop, terminating In nodular, solid angiosarcoma composed of spindle-shaped or polyhedral cells which undergo necrosis or hemorrhage (secondary pellosls). The Interaction between hepatocytes and sinusoidal cells requires elucidation. Descriptors: CARCINOGENS OCCUPATIONAL EXPOSURE SILVER IMPREGNATION DIAGNOSIS Concept Codes: MICROSCOPY-CYTOLOG.CYTOCHEM TECH(*01054 ) ; CYTOLOGY/CYTOCHEM-HUMAN(02508); SOCIAL BIOL/HUMAN ECOL0GY(O55- 00): RADIATION BIOL-RADTN.ISOTOP TECH(06504); RADIATION BIOL-RADTN EFF,PR0TECT(*06506): BIOCHEM STUD-GENERAL( 10060): BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACD( 10064); MINERALS(100- 69): BIOPHYS-MEMBRANE PHENOMENA(10508); ANATOMY/HISTOL-MICRO,- ULTRAMICRSC(11108): PATHOLOGY-COMPARATIVE(12503); PATHOLOGY-D IAGNOSTIC ( 1 2504 ); PATHOLOGY-THERAPY( 125 12 ) ; 0IGE5TJVE SYST-GENL STUDS.METHS(14001); DIGESTIVE SYST-PATHOLOGY(*14006) ; CARDIOVASC SYST-GENL STUDS.METHS(1450t); CARDIOVASC SYST-BLD VESS PATH0L( 14508 ) ; BONE.JNTS.FASC,CONN/AO IP-GENL( 18001 ) ; BONE,JNTS.FASC,CONN/ADIP-PATHOL(18006): PHARMACOL-GENERAL STU DIES (*22002): PHARMACOL-CLINICAL PHARMACOL(22005); TOXICOL-PH ARMACOLOGICAL ( *22504); TOXICOL-ENVIRONMNTL.INOUSTR(*22506); NEOPLSMS/NEOPL AGNTS-DIAGNS METH(24001): NEOPLSMS/NEOPl AGNIS-CARC I NOGENS{* 2 4007); PEDI ATRICS(25000); ENVIRON HE AL Tl l-OCCUPA T NL HEALTH(* 37013): EPI DEM IOL-ORGAN 1C DIS.NEOPLA- SMS(37054) B losystomatIc Codes: HOMINIDA E(8G215) 67010204' DEVELOPMENT OF HEPATIC ANGIO SARCOMA IN MAN INDUCED BY VINYL CHLORIDE THOROTRAST AND ARSENIC COMPARISON WITH CASES OF UNKNOWN ETIOLOGY POPPER H; THOMAS L B: TELLES N C: FALK H: SELIKOFF I , I BIOSIS Previews 77-83/1Jen 8A 7502;RRM2402(See FIIe5 R&S 138508 tern 489 of 858) User 3614 25Jan83 2 154 67009009 MUTAGENICITY OF VINYL CHLORIDE EXTERNAL CHROMOSOME STUDIES PERSONS WITH AND WITHOUT VINYL CHLORIDE ILLNESS AND ON VINYL CHLORIDE EXPOSED ANIMALS FLEIG I: THIESS A M DEP. OCCUP. MED. HEALTH PROT., BAD. ANILIN SODA FABR. AG.. 6700 LUDWIGSHAFEN. W. GER. J OCCUP MED 20 (8). 1978 557-561. Coden: JOCMA Language: ENGLISH Chromosome analysis was undertaken on lymphocyte cultures taken from 6 workers with estimated exposure to VC [vinyl chloride] and 4 workers with monitored exposure to VC; 20 workers showing symptoms of VC Illness with unknown exposure and 1 angiosarcoma case. due to VC exposure; and. on bone marrow cells of Chinese hamsters after inhalation of 2500 ppm or .5000 ppm, or after l.p. Injections of 300 mg/kg or 600 mg/kg. The proband groups showing symptoms of VC Illness. the only living angiosarcoma case. and the animal test show a significant increase in the rate of aberrations In comparison to the control group. Descriptors: LYMPHOCYTE CHINESE HAMSTER BONE MARROW CELL ANGIO SARCOMA Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(*02506); CYTOLOGY/C- YT0CHEM-HUMAN(O25OB); GENET IC5/CYT0GENET-ANIMAL(*03506); GENE- TICS/CYTOGENET-HUMAN(*03508); SOCIAL BIOL/HUMAN ECOLOGY(05500) BIOCHEM STUO-GENERAL(10060): BLOOD/BODY FLDS-BLOOD CELL STUDS( 15004 ) ; BLOOD/BODY FLDS-LYMPHAT TISS.RES(* 15008); RESPIRATORY SYST-GENL STUD.METHS(1600 1 ); BONE.JNTS.FASC.CONN/- ADIP-PATHOL(18006); ROUTES OF IMMUNIZ.INFECT.THERAP(22100); TOXICOL -ENVIRONMNTL.INDUSTR(* 22506); NEQPLSMS/NEOPL AGNT5-P AT - H,CLINIC(24 004); NEDPLSMS/NEOPL AGNTS-CARCINOGENS(* 24007); ENVIRON HEALTH-OCCUPATNL HEALTH(* 37013); ENVIRON HEALTH-A IR.WATR.SL POLLN(*37015) Blosystematic Codes: HOMINIOAE(86215); CRICETI DAE(86310) techniques. UItrastruetura1 data Indicate that the mcclvinlsm of thrombus formation on polymeric vascular graft materials may differ extensively dependent upon surface composition. A characteristic deposition and embolization profile for thrombi containing radiolabeled platelets and fibrinogen was found with each polymeric material tested. Preadsorption of fibrinogen and fibronectln to polyvinyl chloride (PVC) shunt tubing enhanced Its thrombogen1cIty but had little effect on the form of the surface-spec Ific curve relating platelet density/1000 .mu.m2 to time of blood exposure. Increased numbers of po1ymorphonuc1 ear neutrophils (PMN) were associated with thrombi on fIbronectin-coatod PVC shunts. Immuno1abeIing showed the initial adherence of platelets and PMN on pre-coated surfaces to be related to fibronectln deposits, and allowed speculation that a significant proportion of the previously reported activity of fibrinogen In mediating cel I-substrate Interactions on medical polymers may be due to Its content of fibronectln. The most suitable polymeric materials for extracorporeal circulation devices apparently will be those which adsorb minimal amounts of fibronectln and fibrinogen during the early stages of blood contact. Descriptors: DOG PLATELETS FIBRINOGEN FIBRONECTIN POLY VINYL CHLORIDE POLYMORPHONUCLEAR NEUTROPHILS EXTRACORPOREAL CIRCULATION DEVICES Concept Codes: ELECTRON MICROSCOPY(01058); CYTOLOGY/CYTOCHE M-ANIMAL (02506); RADIATION BIOL-RADTN.ISOTOP TECIK06504 ) ; BIOCHEM-GASES(10012); BIOCHEM STUD-GENERAL< 10060); BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACD(*10064); BIOCHEM STUD-CARBOH- YDR.(1006B); BIOPHYS-GENERAL BIOPHYS TECH(10504); BIOPHYS-BIQ- ENGINE ERING(* 10511); ENZYMES-METHODS(10804); CARDIOVASC SYST-GENL STUDS.METHSt* 14501): CARDIOVASC SYST-BLD VESS PATHOLf 14508) ; BLOOD/BODY FLDS-GENL STUDS.METHS(15001 ): BLOOD/BOOY FLDS-BLOOD.LYMPH STUD(* 15002); BLOOD/BODY FLDS-BLOOD CELL STUDS(*15004); BLOOD/BODY FLDS-LYMPIIAT TISS.RESC* 1500B); IMMUNOL/IMMUNOCHEM-GEN METH(34502) BlosystematIc Codes: CANIOAE(85765) 67007039 SHORT-TERM INTERACTIONS OF BLOOD WITH POLYMERIC VASCULAR GRAFT MATERIALS PROTEIN ADSORPTION THROMBUS FORMATION AND LEUKOCYTE DEPOSITION BARBER T A; MATHIS T; IHLENFELD J V; COOPER S L: MOSHER D F DEP. PATHOL., UNIV. WIS.. MADISON, WIS. 53706, USA. SCANNING ELECTRON MICROSC 1978 (2). 1978 431-440. Coden: SEMY8 Language: ENGLISH Adherence of formed blood elements and adsorptIon of plasma proteins to the surface of polymers commonly used In blood collection devices, dialyzers and oxygonators were examined using an ex vivo arteriovenous shunt model, rad Io1abe1 Ing. Immuno1abe1tng and correlative scanning and transmission electron microscopy. Platelets Isolated from the blood of canine experimental subjects and fibrinogen were rad 1o1 so tope-tagged and returned to the circulation prior to the beginning of experiments. Fibrinogen and fibronectln adsorbed to shunt materials prior to use or during blood exposure wore visualized directly rnrnf'inni rl I on nr>t Inlnhul in*j pnr| through the uso of < ionnn**F*vifHep t y* the DIALOG Flle5: BIOSIS Prev 1 ews. 77 - 83/Jan BA7502;RRM2402(See Fllo55) (c. E R&S 138509 Of 858) User 3614 25Jan83 2155 67006062 THE EFFECTS OF ORGANIC COMPOUNDS USED IN THE MANUFACTURE OF PLASTICS ON THE RESPONSIVITY OF MURINE AND HUMAN LYMPHOCYTES THURMAN G B; SIMMS B G; GOLDSTEIN A L; KILIAN D J DIV. BIOCHEM.. UNIV. TEX. MED. BRANCH. GALVESTON. TEX. 77550. USA. TOXICOL APPL PHARMACOL TXAPA *14 (3). 1978 6I7-6<12. Coden: Language: ENGLISH The effects of acute exposure to a number of Industrially Important organic compounds on the Immunological responses of human and murine lymphocytes were studied. The compounds were benzene. 1.4-dtoxano. toluene diisocyanate (TDI), vinyl chloride, vinyl idene chloride, e thy 1 en lin 1 ne arid epIch1orohydr1n. Control compounds known to have Immunological effects were azoth1 opr 1ne, hydrocortisone acetate and tr1ethy1enemelam 1ne (TEM). Tho uptake of trltiated thymidine ((3H]TdR) of lymphocytes was used to measure their ability to respond to mitogenic agents, allogeneic lymphocytes or the antigenic nature of the compounds themselves. Most of the compounds were cytotoxic to lymphocytes at high concentrations. Dloxane and TDI showed evidence of specific actions on the Immunological system. Dloxane suppressed T(thymus-dor 1ved]-cel 1 responses while augmenting B[bone marrow-der1vedJ-ceI 1 responses. TDI exhibited stimulatory effects at several concentrations to both human and murine lymphocytes. Of the chemicals studied, both dloxane and TDI apparently have properties making them capable of affecting lymphocytes In ways other than nonspecific cytotoxicity. These properties make TDI and dloxane Interesting when monitoring Immunological systems of Industrial workers accidentally exposed to these compounds at high concentrations or routinely exposed to minimal levels of these compounds. Descriptors: WORKERS BENZENE 1 4 DIOXANE TOLUENE DI ISO CYANATF. VINYL CHLORIDE VI NYL I DENE CHLORIDE E THY L EN I M I NE EPI CHLOROHYDRIN AZA Till OPR INE HYDROCORTISONE ACETATE T RI ETHYLENE MELAMINE Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506): CYTOLOGY/CY- TQCIIEM-HUMAN(02508); SOCIAL BIOL/HUMAN ECOLOGY(05500); RADIATION BIOL-RADTN,ISOTOP T ECI l(06504): BIOClirM STUD-GENERAL- (10060); BIOCHEM STUD-NUCL ACO,PURNS.PYRM(10062); BIOCHEM STUD-STEROLS.STEROIDS( 10067); MOVEMENT( 12 100): METABOLISM-NUCL ACD,PUR I NS.PYRIM( 13014); BLOOD/BOOY F LDS-BLOOD CELL STUDS ( 1 500*1 ) : BLOOD/BODY F LDS - L YMPHAT T I SS . RE S ( * 1 5000 ) ; ENDOCRINE SYST-THYMUS( 17016); RONE.JNTS.FASC.CONN/aD1P-GENL( 1 - 0001); TOXICOL-ENVIRONMNTL.INDUSTR(* 22506); NEOPLSMS/NEOPL AGNTS-CARCINOGENS(2*1007 ) ; IMMUNOL/IMMUNOCHEM- IMMUNOPATHOL(+3*1508); ENVIRON HEALTH-OCCUP- ATNL HEALHlf +37013); ENVIRON HEALTH-A IR.WATR,SL PDLLNf* 37015) Blosystomat1c Codes: H0M1NIDAE(86215); MUR I DAE(86375) ENVIRON RES 16 (1-3). 1978 285-301. Coden: ENVRA Language: ENGLISH Neoplastic effects of vinyl chloride were studied In lungs of 27 mice exposed to vinyl chloride monomer at 2500 and 6000 ppm for 5 and 6 mo. Pulmonary tumors were observed In 26 of 27 experimental animals. By light microscopy, the tumors wera' multiple and arranged In either tubu1o-pap111 ary or adenomatous formations. Although occasional mitotic divisions and Invaginations into the bronchlolar lumen were observed, no metastases were found. By EM, short microvilli. tight Junctions between 2 adjacent cells, appearance of osmlophlllc lamellar hodles, large mitochondria of irregular shape, we I I-deve1 oped Gotgf complexes, continuous or discontinuous basement membranes, occasional appearance of seguestrat1 on and of crystalloids, and lack of both cilia and mucous secretory granules were observed as characterIstIc features of the neoplastic cells. Some of the cells were poor 1y differentiated and were equipped with poorly developed organoids. without formation of osmlophlllc lamellar bodies. The pulmonary tumors corresponded to alveologenlc tumors or alveologenlc cancer. The neoplastic cells were probably transformed from type II alveolar epithelium via Its hyperplastic form. Mouse lung is an extremely sensitive Indicator of the oncogenicity of vinyl chI or 1de. Descriptors: CARCINOGEN CELLULAR CHANGES LIGHT MICROSCOPY ELECTRON MICROSCOPY Concept Codes: MICROSCOPY-GENL.SPECL TECI INIQUES(01052): MICROSCOPY-HISTOL.HISTOCHEM TECH(01056); ELECTRON MICR0SC0PY(: 01058); CYTOLOGY/CYTOCHEM-ANIMALt*02506): BIOCHEM STUD-GENERA- L( 10060); BIOPHYS"MOLECUL PROP.MACROMOLEC( 10506); BIOPHY5-MEM BRANE PHENOMENA( 10508): ANATOMY/HISTOL-MICRO,ULTRAM ICRSC(+111- 08): BLOOD/BODY F LDS-LYMPHAT TISS.RES( 15008): RESPIRATORY SYST-ANATOMY(16002); RESPIRATORY SYST-PATHOLOGY(16006); TOXICOL-GENL/EXP SIUOS,ME THS(+22501): TOX1 COL -ENVIRONMNfL. 1 NO - USTR(22506); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS('2 *1007); ENVIRON HEAt. TH-OCCUPATNL HE AL T H( 370 13 ) ; ENVIRON HE AL Til - A I R . WA T R . S L P0LLN(37015) BIosystematIc Codes: MUR I DAE(8G375 ) 6700388A PULMONARY TUMORS INDUCED IN MICE BY VINYL CHLORIDE MONOMER SUZUKI Y ENVIRON. SCI. LAB., MT. SINAI SCH. MED,. FIFTH AVE. AND 1AATH CT MCW vnpu- H V < Ah *10 MCA DIALOG FlleS: BIOSIS Previews 77-83/Jan BA7502;RRM2402(See F i 1o55) R&S 138510 493 of 858) User 3614 25jan83 2 156 C7002739 EFFECTS OF VINYL CHLORIDE IN HAN A CYTO GENETIC FOLLOW-UP STUDY HANSTEEN I -L; HILLESTAD L; THIIS-EVENSEN E; HELDAAS S S LAB. GENET.. TELEMARK CENT, HOSP.. OLAVSGT. 26. 3900 PORSGRUNN. NORW. MUTAT RES 51 (2). 1978 271-278. Coden: MUREA Language: ENGLISH Cytogenetic studies were performed on 39 workers from a PVC [polyvinyl chloride] plant In 1974; 16 healthy men without any connection with the plant were chosen as controls. The cytogenetic study was repeated for 37 of the 39 workers 2-2.5 yr later. During this time Interval the workers had only had a minimal exposure to VCM [vinyl chloride monomer]. This repeated study was performed with 32 matched controls from the office employees In the factory. Breaks, gaps and stable rearrangements were scored In 10O metaphases per person from 48 h lymphocyte cultures. The mean chromosome-breakage frequency for the workers (3.41%) was significantly higher than for the controls (1.79%) In the 1st Investigation. In the repeated study no difference was found In mean chromosome-breakage frequency between the workers and their matched controls. Neither was there any difference between these breakage frequencies and the breakage frequency for the previous control group. A relationship between the reduction In exposure to VCM and the normalized chromosome-breakage frequency Is Indicated. SIster-chromatId exchanges [SCE] were studied for 16 workers with matched controls In the repeated study. A mean of 7.6 SCE/cell was found for both workers and controls. Bone-marrow samples from 4 workers were studied In the 1st Investigation. The mean chromosome-breakage frequency was higher in the bone marrows (4.2%) than that reported for normal bone marrows (0.2, 0.4, 1.7%), and higher than for the correspond 1ng lymphocyte cultures. Descriptors: WORKER BONE MARROW LYMPHOCYTE Concept Codes: CYTOLOGY/CYTOCHEM-HUMAN(*02508): GENET ICS/CY- TOGENET-HUMAN(*03508); MATHEMATIC BlOL/STAT I ST IC METH(OASOO): SOCIAL BIOL/HUMAN ECOLOGY(05500): BLOOD/BODY F LDS-LYMPHAT TISS,RES(15008): BONE, vJNTS.FASC.CONN/AD 1P-GENL(18001); T0XIC0- L-ENVIRONMNTL. INDUSTR(*22506); TIS5 CULTURE-APPARAT.METHS.MED - IA(32500); ENVIRON HEALTH-OCCUPATNL HEALTH(*37013); ENVIRON HEALTH-AIR,WATR.SL POLLN(*37015) BlosystematIc Codes: HOMINlDAE(86215) 67001646 PROGRESS REPORT ULTRASOUND AND GASTRO ENTEROLOGY TECHNICAL CONSIDERATIONS VICARY F R UNIV. COLL. HOSP., LONDON, ENGL., IJ K. CUJT 18 (5). 1977 386-397. Codun: C.UTTA Language:- ENGLISH Recent technical advances in ultrasonic Imaging have opened up now diagnostic possibilities for the gastroenterologist. This report discusses important points which are necessary for Interprctat1 on of what anatomy arid pathology can or cannot bn seen by ul t rnson I or., Pntbolonli's rllsouxaml Itv.link.' I nunrl lr** liver tumors; hepatic cysts; vinyl chloride liver disease; diseases of the pancreas; and abdominal masses. Descriptors: HUMAN DIAGNOSIS Concept Codes: RADIATION BIOL-RADTN,ISOTOP TECH(*06504); BIOCHEM STUD-GENERAL(10060): BIOPHYS-GENERAL BIOPHYS TECH( 10504): PATHOLOGY-GENERAL STUD IES( 12502): PATHOLOGY-DI AG NOSTIC (12504); DIGESTIVE SYST-GENL STUDS.METHS(*14001); DIGESTIVE SYST-ANATOMY(14002); DIGESTIVE SYST-PATHOLOGY(*1400- 6); TOXICOL-GENL/EXP STUDS,METHS(22501); NEOPLSMS/NEOPL AGNTS-DIAGNS METH(24001) BIosystematIc Codes: HOMINIDAE(86215) 67001014 AN IMPROVED LATEX INJECTION MEDIA FOR REPLICATING THE PULMONARY MICRO VASCULATURE FRASCA J M: CARTER H W; SCHAFFER W A LAB. SENIOR MED. INVEST.. VETERANS ADM. HOSP.. EAST ORANGE. N.J. 07019. USA. SCANNING ELECTRON MICROSC Coden: SEMYB 1978 (2). 1978 485-489. Language: ENGLISH A highly stable replica [In anesthetized guinea pigs) was obtained by blending a plasticized vinyl chloride copolymer with a vinyl chloride copolymer In a ratio of 3:1 containing 1.0% polyethylene glycol (MW 400) and 6.0% Hypaque (dlatrlzoate sodium). Complete polymerization of the latexes was best accomplished by critical point drying prior to digestion of the tissue. The replicating media meets the criteria established for SEM (scanning electron microscope] examination, l.e.. It completely fills the pulmonary vascular system, polymerizes and dries without shrinkage or distortion, can be rendered conductive and withstands electron beam 1 rrad I a tIon. Descriptors: GUINEA-PIG VINYL CHLORIDE CO POLYMER POLY ETHYLENE GLYCOL DIATRIZOATE SODIUM ELECTRON MICROSCOPY Concept Codes: ELECTRON MICROSCOPY(*01058); RADIATION BIOL-RADTN.ISOTOP TECH(06504); BIOCHEM STUD-GENERAL(10060); EXTERN EFF-C0LD( 10616): NUTRITI ON-GENL.NUTR STATUS.METHS( 1 320- 2); CARO I OVA SC SYST-GENL STUDS.METHS(* 14501): RESPIRATORY SYST-GENL STUD.METHS(* 16001); RESPIRATORY SYST-PIIYSIOL.BIOCHEM(*16004); NERVOUS SYST-PHYSIOL,BIOCHEM(20504); PHARMACOL - NEU ROPHARMACOLOGY (22024); ROUTES OF IMMUNIZ.INFECT.THERAP(22100); TEMPERAIURE-GENL,METHS(23001); TEMPERATURE-CRYOBIOLOGY(23004 ) BIosystemat1c Codes: CAVI I DAE(86300) DIALOG Fi1eS: BIOSIS Previews 77-B3/Uan BA7502:RRM2402(See FileSE R&S 138511 litem 496 of 858) User 3614 25Jan83 2157 67000938 NEW APPROACH TO STUDY OF CONNECTIVE TISSUE VASCULAR DISEASE LEROY E C: MARICO H R DIV. RHEUMATOL. IMMUNOL., DEP. MED.. MED. UNIV. S.C., CHARLESTON, S.C., USA. CARD IOVASC MED 3 (7). 1978 695-696. Language: ENGLISH Coden: CMEDD The pathogenesis of scleroderma and other human vasqular connective dlsese Is reviewed. Inborn errors of metabolism and exposure to vinyl chloride (VC) are Implicated as causes. Scleroderma and VC related disease In animal models `are compared. Descriptors: HUMAN ANIMAL MODEL SCLERODERMA VINYL CHLORIDE Concept Codes: BIOCHEM STUD-GENERAL(10060); PATHOLOGY-GENER- AL STUDIES( 12502); PATHOLOGY-COMPARATIVE(12503); METABOLISM-G- ENL STUD.METAB PATHW( * 13002); METABOLISM-METAQOLIC DISORDERS(* 13020); CARDIOVASC SYST-8LD VESS PATHOL(*14508); BONE.JNTS.FASC.CONN/AD IP-GENL( 18001)j BONE ,.JNTS.FASC,CONN/AD IP-PATHOL(* 18006); INTEGUMENT SYST-GENL STUDS.METHS( 18501 ): INTEGUMENT SY ST - PATHOLOGY( IB506); TOXICOL'ENVIRONMNTL,INDUSTR(*22506); IMMUNOL/IMMUNOCHEM-IMMUNOPATHOL(*34508); ENVIRON HEALTH-A IR,WATR.SL POLLN(370 I 5) BtosystematIc Codes: VERTEBRATA-UNSPECIFIED(85150): HDMINID- AE(862 15) 67000531 PLATELET STORAGE AT 22 CELSIUS EFFECT OF TYPE OF AGITATION ON MORPHOLOGY VIABILITY AND FUNCTION IN-VITRO HOLME S: VAIDJA K; MURPHY S CARDEZA FOUND. HEMATOL. RES., 1015 WALNUT ST., PHILADELPHIA. PA. 19107. USA. BLOOD 52 (2). 1978 425-435. Coden: DLOOA Language: ENGLISH Recovery In vivo after SlCr labeling, platelet morphology and platelet aggregation were studied with platelet concentrates (PC) stored for transfusion under carefully controlled conditions. PC were prepared to a final volume of 50 ml from whole blood anticoagulated with c1trate-phosphate-dextrose (CPD). The platelet count was kept between 0,8-1.6 .times. 1012 pi ate1ets/11 ter. The PC' were stored In bags constructed of polyvinylchloride (PVC) or polyethylene (PE) at 22.degree. C for 72 h. The bags wore placed on a horizontal shaker or a ferrls wheel for agitation during storage. No significant changes In pH or platelet count were observed during storage. PC stored on the wheel showed moderate Joss of viability and a marked do ter I oratI on of platelet morphology and aggregation compared to tho shaker, PC stored on the shaker In bags made of PE showed better aggregation with AOP and thrombin, but had the same viability and morphology as PC In bogs constructed of PVC. Maintenance of normal platelet morphology, as determined by phase - contrast microscopy. extent of shape change response, and tho size distribution according to the Coulter Counter correlated with recovery In vivo. Dnv:r lr>lnrr, : POLY FTHYI.FNC 0405 POI.Y VINYL CHLORIDE BAGS THROMBIN ADP AGGREGATION Concept Codes: MICROSCOPY-CYTOLOG.CYTOCHEM TECH(O 1054 ) ; CYTOLOGY/CYTOCHEM-ANIMAL( *02506): RADIATION BIOL-RADTN. I SOTOP TECH(06504); BIOCHEM STUD-GENERAL(10060): BIOCHEM STUD-NUCL ACO.PURNS,PYRM(10062); BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACD( 10064); BIOCHEM STUD-CARBOHYDR.( 10068): MINERALS( 10069 ) : EXTERN EFF-TEMPERATURE(* 106 14); ENZYMES-PHYSIOLOGICAL STUDIES- (10808): ANAT0MY/HI5T0L-REGEN.TRANSPLANT 11 107): MOVEMENT( 1 2 1 - oo): PAT1I0L0GY-THERAPY( 12512) ; BLOOD/BODY FLOS-GENL STUDS.METHS(* 15001): BLOOD/BODY FLDS-BLOOD.LYMPH STUD( 15002); BLOOD/BODY FLDS-BLOOD CELL STUDS(*15004); TEMPERATURE-GENL.ME - TMS(23001) Blosystematlc Codes: VERTEBRATA-UNSPECIFI ED(85i50) 17059948 ENGINEERING CONTROL TECHNOLOGY IN POLY VINYL CHLORIDE POLYMERIZATION PLANTS GIDEON J A J ENVIRON PATHOL TOXICOL JEPTD 2 (5). 1979 285-318 Codon: Descriptors: HUMAN ILLNESS PREVENTION EQUIPMENT MODIFICATION VENTILATION WORK PRACTICE EDUCATION MANAGEMENT Concept Codes: GENL BIOL-TXTBKS.EDUCATN.AUD-VIS(005 I 4); SOCIAL BIOL/I IUMAN ECOLOGY(05500): BIOCHEM STUD-GENERAL( 10060 ) ; BIOPHYS-BIOENGINEER ING(10511); PATHOLOGY-GENERAL STUD IES( 125- 02): METABOLISM-GENL STUD.METAB PATHW( 13002); TOXI COL-ANT I DOT ES. PREVENTIVE! *22505): T0X1COL -ENVIRONMNTL.INOUSTR(*2 2506 ) ; ENVIRON HEALTH-OCCUPATNL HEALTH(* 370 13) BlosystematIc Codes: HOM1N1DAE(862 15 ) 17054944 FORMATION OF CHLORINATED HYDRO CARBONS DURING COMBUSTION OF POLY VINYL CHLORIDE AHLING B; BJORSETH A; LUNDE G CHEMOSPHERE 7 (10). 1978 799-806 Coden: CMSHA Descriptors: AIR POLLUTION Concept Codes: ECOLOGY-BIOCLIMATOL.BIOMETEOROL(*07504 ) ; BIOCHEM STUD-GENERAL(10060); ' MINERALS(10069): EXTERN EFF-HOT( 106 18): TOXI COL-ENVIRONMNTL.INDUSTR(*22506): TEMPERAT URE -GENL.METHS(23001); ENVIRON HEALTH-A IR.WATR,SL P0LLN(*37O1- 5) DI ALO e5: BIOSIS Previews 77-B3/dan BA7502;RRM2A02(See Fll 170501 4 1 EVOLUTION OF THOROTRAST INDUCED HEPATIC ANGIO SARCOMAS TELLES N C: THOMAS L B; POPPER H; 1SHAK K G: FALK H ENVIRON RES 18 (1). 1979 74-87 Coden: ENVRA Descriptors: HISTOLOGY HUMAN VINYL CHLORIDE ARSENICALS CARCINOGENS Concept Codes: MICROSCOPY-HISTOL,HISTOCHEM TECH(01056); CYTOLOGY/CYTOCHEM-HUMAN(*02508); RADIATION B1OL-RADTN.ISOTOP TECH(0G504): RADIATION BIOL-RADTN EFF,PROTECT(*06506); BIOCHEM STUO-GENERAL(10060): MINERALS{10069); ANA TOM Y/E1 [STOL - MICRO,UL- TRAMICR5C!* 1 1 108 ) ; PATHOLOGY-COMPARAT IVE( 12503); DIGESTIVE SYST-GENL STUDS,METHS(14001); DIGESTIVE SYST-PATHOLOGY(*14006) : CARDIOVASC SYST-GENL STUDS,METHS(14501); CARDIOVASC SYST-BLD VESS PATHOL( * 14508) : TOXI COL - GENl. / E XP STUDS . METHS (* 2250 1 ) : TOXICOL-FOOD,RESI OS.ADO IT,PRESRV(*22502): NEOPLSMS/NEOPL AGNTS-CARC I NOGENS(*24007) B 1 osys tenia t 1 c Codes: HOM INI DAE (862 15 ) 17049614 METABOLIC ACTIVATION OF VINYL CHLORIDE IN DROSOPHILA-MELANOGASTER AFTER PRE TREATMENT WITH INDUCERS OF MICROSOMAL DE TOXICATION ENZYMES MAGNUSSON d; HALLSTROM I; RAMEL C MUTAT RES 64 (2). 1979 138-139 Coden: MUREA Descriptors; ABSTRACT MAMMAL INSECT HIKONE STRAIN DI METHYL SULFOXIDE PHENO BARBITAL CLOPHEN METABOLIC-DRUG MUTAGEN CARCINOGEN INSECTICIDE RESISTANCE CARBON-14 Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(*02506); GENETICS/C- YTOGENET-ANIMAL(*03506): RADIATION BIOL-RADTN.ISOTOP TECH(065- 04); BIOCHEM METH-GENERAL(10050); BIOCHEM STUD-GENERAL(10060): BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACD(10064); ENZYMES-PHYS- IOLOGICAL STUDIES!10808); PHYSIOLOGY-COMPARATIVE(12003); METABOLISM-GENL STUD,METAB PATHW(* 13002 ) ; DIGESTIVE SYST-PHYSIOL,BIOCHEM{ 14004); PHARMACOL-DRUG MET AB,ME T AB STIMU1 *22003) : PHARMACOL-DIGESTIVE SYSTC22014 ); ROUTES OF JMMUNIZ,INFECT.THERAP(22100); TOXICOL-GENL/EXP STUDS.METHS(*2 - 2501); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(24007): PEST CONTRL GENL/PESTIC5/HER8ICS(54600); ECONOM ENTOMOL-CHEM PHYS CONTRL(60016); INVERTB PHYSIOL-I NSECTA-PHYSIOL(64076); INVERTB PHYSIOL-INSECTA-PATHOL(*64078) Blosystemat1c Codes: INSECTA-UNSPECIFIE0(75300): DIPTERA(75- 314); MAMMAL IA-UNSPECIFI ED AND EXT INCT(85700); ABSTRACTS OF ENTOMOLOGY(96000) (c, BIOSI; A385^2 58) User 3614 25J 2 158 YTOGENET-ANIMALl*03506); GFNETICS/CYTOGENET- HUMAN(*03508 ) ; BIOCHEM STUD-GENERALl 10060); BIOCHEM STUD-PROTEI NS.PEPTIOES.AMINO ACO( 10064); ENZYMES-METHODS( 10804 ); ENZYMES-PHYS1OLOGI CAL STUDIES!* 10808); FOOD TECH-PREP,PROCESSNG.STORAGE( 1 3532 ) ; DIGESTIVE SYST-PHYSIOL.BIDCHEM( 14004 ); PIIARMACOL-DRUG METAB.M- ETAB STJMU(*22003); PHARMACOL-0IGESTIVE SYST(22014); TOXICOL-GENL/EXP STUDS.METHS(* 22501): TOXI COL-FOOD.RESI OS.ADD - IT ,PRESRV(*22502); BACTERIAL AND VIRAL GENET ICS(31500): MICROBIOLOG APPARAT.METHS,MEDIA(32000) Blosystemat(c Codes: ENTEROBACTER1 ACEAE(04810): IIOMINIQAE(8 - 6215); MURI0AE(86375) 17049157 EFFECT OF CHRONIC VINYL CHLORIDE POISONING ON THE REGULATION OF CARBOHYDRATE METABOLISM KURLYANDSKJI B A; KLOCHKOVA S I; ROTENBERG YU S: T0M1LINA L A; STOVBUR N N GIG TR PROF ZABOL (7). 1978 54-55 Coden: GTPZA Descriptors: NOTE RAT SUGAR INSULIN Concept Codes: BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACD(10064): BIOCHEM STUD-CARBOHY- DR.( 10068): METABOLISM-GENL 5TUD.METAB PATHW( 13002): METABOLISM-CARBOHYDRATES!* 13004); ENDOCRINE SYST-PANCREAS{*17- 008): TOXICOL-GENL/EXP STUDS.METHS(*22501) Blosystemntic Codes: MURIDAE(86375 ) 17048603 CURRENT METHODS FOR DETERMINATION OF AIR POLLUTION ON INDUSTRIAL PREMISES ALEKPEROV I I; KYAZJMOVA G P AZERB MED ZH (3). 1978 49-54 Coden: AZMZA Descriptors; HUMAN RUBBER POLY VINYL CHLORIDE LINOLEUM ALUNITE CHROMATOGRAPHY SPECTROPHOTOMETRY PHOTO COLORIMETRY POLAROGRAPHY Concept Codes: ECOLOGY-BIOCLIMATOL.BIOMETEOROL!*07504); BIOCHEM METH-GENERAL!* 10050); BIOCHEM STUD-GENERAL( 10060): 8I0PHYS-GENERAL BIOPHYS TECH!* 10504): MOVEMENT( 12100): TOXICOL-ENVIRONMNTL,INDUSTR(*22506); ENVIRON HEALTH-OCCURATNL HEALTH!*37013): ENVIRON HEALTH-A 1R.WATR.SL POLLN(370 15 ) Blosystemat Ic Codes: HOMINIDAE(862 15) 17049604 IMPACT OF MICROSOMAL ENZYMES ON THE MUTAGENICITY OF ACRYLONITRILE BUTADIENE AND STYRENE DE MEESTER C; PONCELET F; ROBF.RFROID M; MERC 1ER M MU1A 1 RES 64 (2 ). 1979 132 Codon: MUREA Descriptors: ABSTRACT SALMONELLA-TYPHI MUR IUM TA-1530 TA-1535 T A - 100 STRAINS RAT MOUSE HUMAN S-9 L TVER MICROSOME AMES TEST VINYL CHLORIDE AROCLOR 1254 PHENO BARBITAL METHYL-3 CHOLANHIRENE METABOLIC-DRUG FOOD PACKAGING Concept Codes:- CYTOLOGY/CYTOCHEM-AN IMAL(*02506): GENETICS/C- DIALO' 1e5: BIOSIS Previews 77-03/dan BA7502;RRM2402(See F11e55) (c. BIOSIS 198*: 13851$ I) User 3614 25janB3 2159 17047 148 GAS CHROMATOGRAPHIC DETERMINATION OF VINYL CHLORIDE LEVELS IN THE BLOOD OF TREATED LABORATORY ANIMALS AND THE EFFECT OF VINYL CHLORIDE MONOMER ON DIFFERENT TOXICOLOGICAL PARAMETERS HOLLO A; KNEFFEL Z; VARGA L PROC HUNG ANNU MEET BIOCHEM 10. 1978 97-90 Coden: PHABO Descriptors: ABSTRACT RAT RABBIT PSYCHO PHYSIOLOGICAL CHANGE NEURO TOXICITY CYTOCHROME P-450 IMMUNO SUPPRESSION Concept Codes: BEHAVIOR BIOL-ANIMAL 8EHAVI0R(O7OO3); BIOCHEM STUD-GENERALC10060); BIOCHEM STUD-PROTEIN5.PEPTIDES.AMI NO ACD(10064); BIOCHEM STUD-PORPHYRNS.BILE PIGM(10065); ENZYMES-GEN.COMPAR STUO,COENZYMS(*10802); NERVOUS SYST-PATHOL- OGY(*20506); PSYCHIATRY-P SYCHPATH-DYNM,THE RAP( *2 1002): TOXI CO - L-GENL/EXP STUOS,METHS(*22501); TOXI COL-ENVIRONMNTL.INDUSTR ( 2 - 2506); IMMUNOL/IMMUNOCHEM-IMMUNOPATHOL(*34508) Blosysternat1c Codes: LEPORIDAE(B6040): MUR I DAE(86375) 17042685 THE KINETICS OF POST REPLICATION REPAIR IN MAMMALIAN CELLS AS STUDIED BY THE ALKALINE ELUTION TECHNIQUE MEYN R E; FLETCHER S E J SUPRAMOL STRUCT 7 (SUPPL 2). 1978 17 Codon: dSPMA Descriptors: ABSTRACT CHINESE HAMSTER CELL CYCLO HEXIMIDE UV LIGHT ALKALINE SUCROSE GRADIENT EDTA TETRA PROPYL AMMONIUM HYDRO CHLORIDE POLY VINYL CHLORIDE FILTER Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(*02506): GENETICS/C- YTOGENET-ANIMAL( *03506); MATHEMATIC BIOL/STATISTIC METH(04500) RADIATION BIOL-RADTN,ISOTOP TECH(06504): RADIATION BIOL-RADTN EFF,PROTECT(*06506); BIOCHEM METH-NUCL ACD.PURNS.P- YRM(10052); BIOCHEM STUD-GENERAL(10060); BIOCHEM STUO-NUCL ACD.PURNS,PYRM(10062); BIOCHEM STUD-CARBOHYDR.(10068): REPLICATN.TRANSCRIPTN.TRANSLATNf * 10300): BIOPHYS-GENERAL BIOP- HYS TECH( 10504); BIOPHYS-MOLECUL PROP,MACROMOLEC( 10506); MOVEMENT( 12100): METABOLISM-NUCL ACD.PUR INS.PYRIM( 130 I 4); PHARMACOL-DRUG MET AB.MET AB ST I MU ( * 22003) : TISS CULTURE-APPARA- T,METHS,MEDIA!32500); PEST CONTRL GENL/PESTICS/HERBICS(54C00) BlosystemntIc Codes: MAMMAL IA-UNSPECIFI ED AND EXT INCT(85700) : CRICETI0AE(86310); ABSTRACTS OF MYCOLOGY(95000) ; ENVIRON HEALTH-AIR.WATR.SL POLLN(*37015) 17040664 FORMATION OF ETHENO DERIVATIVES OF NUCLEIC-ACID BASES IN-VIVO BY METABOLITES OF VINYL CHLORIDE LAID R J: OTTENWAELDER H; BOLT H M IIOPPE-SEYLER'S Z PHYSIOL CHEM 359 (3). 1978 293 Coden: H5ZPA Descriptors: RAT CARCINOGENIC MUTAGENIC ADENINE CYTOSINE RNA DNA Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506); GENETICS/CY- TOGENF.T-ANIMAL( *03506 ) ; BIOCHEM ST UD - GENE RAL ( 10060 ) ; BIOCHEM STUD-NUCL ACD.PURNS.PYRM( 10062): METABOLISM-GENL STUD.MET AB PATHW(13002); METABOLISM-NUCL ACD.PUR INS.PYRIM(* I 30 I 4 ) ; TOXICOL-GENL/EXP STUDS.METHS(*22501): TOXI COL-ENVIRONMNTL.INO- USTR(22506): NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(*24007) Btosystemat1c Codes: MURIDAE(86375) 1703G152 BACTERIOLOGY OF MINERAL WATERS INFLUENCE OF POLY VINYL CHLORIDE ON THE GROWTH OF PSEUDOMONAS-AERUGINOSA AND PSEUOOMONAS-FLUORESCENS MASSON A; MICHEL R; RICHOZ E EXPERT ENT IA (BASEL) 34 (12). 1978 1665- 1666 Coden: EXPEA Descriptors: ABSTRACT PLASTIC FILM DEGRADATION Concept Codes: ECOLOGY-LIMNOLOGY(*07514); ECOLOGY-WATR RESRCH, FISHERY BI0U07517); BIOCHEM STUO-GENERAL( 10060) : MINERALS! 10069); TOXI COL-ENVIRONMNTL.INOUSTR(*22506 ) ; BAC1ERI- A-PHYSIOLOGY.BIOCHEMISTRY!*3lOOO): ENVIRON HEALTH-A IR.WATR.SL POLLN(*37015); FOOO/INOUS MICRO-FD/BEV SP CNTAMl*39002); FOOD/I NOUS MICRO-BIODEGRAD.DE T ER(*39006) BlosystematIc Codes: PSEUDOMONADACEAE(04716) 17041411 THE ROLE OF SINGLET OXYGEN IN THE PHOTO OXIDATION OF POLYMERS RABEK J F; RANBY B PHOTQCIIEM PHOT OB IOL 28 (4/5). 1978 557-570 Coden: PHCBA DescrIp1urs: MICROWAVE GENERATOR POLY DIENE POLY STYRENE POLY VINYL CHLORIDE QUENCHERS CAROTENE AMINE SUBSTITUTED PHENOL METAL CHELATE Concept Codes: RAO I AT ION BIOL-RADTN.I SOI OP TECH(0C504); ECOLOGY -13 I OCL IMA TOL. BIOMET EOROLt *07504 ) ; B 1 OCIIEM-GA S E S ( 100 1 2 ) : BIOCHEM STUD-GENERAL( 10060): BIOCHEM STUDV1 TAMJNS( 10063); BIOCHEM STUO-PROTCINS,PEPTIDES.AMINO ACD(10064): BIOCHEM STUD-LIPIDS(10066): MINERALS(10069): BIOPHYS-GENERAL BI0PI1YS TECH( 10504); BIOPHYS-MOLECUL PROP.MACROMOLEC( 10506); EXTERN EFF-LIGHT.OARKNESSt 10604); TOX I COL -ENVIRONMNT 1. . INOUST R( *27506) D1AL0 le5: BIOSIS Previews 77-83/Jan BA7502;RRM2402(See FI 1e5!>) (c. BIO R&S 138514 858) User 3614 25Jan83 2160 17029971 INDOCYANINE GREEN CLEARANCE AS THE PROSPECTIVE INDICATOR OF HEPATO CELLULAR CHEMICAL TOXICITY TAMBURRO C H; CREECH J L; DAVIS A; GREENBERG R A GASTROENTEROLOGY 75 (5). 1978 989 Coden: GASTA Descriptors: ABSTRACT HUMAN WORKER OCCUPATIONAL EXPOSURE VINYL CHLORIDE DIAGNOSTIC-DRUG GASTROI NTESTINAL-DRUG Concept Codes: CYTOL0GY/CYTOCHEM-HUMAN(O25O8) ; SOCIAL BIOL/HUMAN ECOLOGY (05500); BIOCHEM STUD-GENERAL(10060): ANATOMY/HISTOL-MICRO.ULTRAMICRSC(11108): METABOLISM-GENL STUD- .METAB PATHW(* 13002); DIGESTIVE SYST-GENL STUDS ,METH5( * 14,001 ) : DIGESTIVE SYST-PATHOLOGY(14006); PHARMACOL-CL INICAL PHARMACO- L(2 2005); PHARMACOL-DIGEST IVE SYST(* 220 14 ) : TOXICOL-GENL/EXP STUDS,METHS(*22501); TQXICOL-ENVIRONMNTL,INDU5TR(* 22506): NEO- PLSMS/NEOPL AGNT S-CARCI NOGENS(24007); ENVIRON HEALTH-OCCUPATNL HEALTH(*37013); ENVIRON HEALTH-AlR,WATR.SL POLLN(*37015) B losystemat Ic Codes: HOMINIOAE(86215) 17029849 URINARY GLYCOSAMINO GLYCAN PATTERNS IN HUMAN HEPATIC ANGIO SARCOMA HEPATOMA AND IN WORKERS AT RISK FOR ANGIO SARCOMA CURRAN K L; KUPCHELLA C E; SANDOZ J: TAMBURRO C H GASTROENTEROLOGY 75 (5). 1978 959 Coden: GASTA Descriptors: ABSTRACT URINE VINYL CHLORIDE CARCINOGEN ANION EXCHANGE CHROMATOGRAPHY Concept Codes: SOCIAL BIOL/HUMAN ECOLOGY(05500): CLIN BIOCHEM-GENL STUD IES( 10006); BIOCHEM METH-PROTNS,PEPTDS,AM AC(10054); BIOCHEM METH-CARBOHYDRATES(10058); BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-PROTEINS,PEPTIDES.AMINO ACO(10064): BIOCHEM STUD-CARBOHYDR.(1006B); BIOPHYS-GENERAL BIOPHYS TECH( 10504): MOVEMENT ( 12100); METABOLISM-CARBOHYDRATES { * 13004); METABOLISM-PROTNS.PEPTDS,AM ACDS(* 13012): DIGESTIVE SYST-PATHOLOGY(14006); CARDIOVASC SYST-BLD VESS PATHOL(*14508); URIN SYST/EXT SECR-PHYSL,B1OCHEM( 15504): TOXI COL-ENVIRONM NTL .INDUSTR(*22506); NEOPLSMS/NEOPL AGNT5-BI0CHEM(*24006): NEOPLSMS/NEOPL AGNTS-CARCINOGENS( *24007) ; ENVIRON HEALTH-OCCUPATNL HEALTH!*37013) B losystematIc Codes: HOMINIDAE{86215) 17029687 CONTROL STATUS OF VINYL CHLORIDE WYATT S TEX REP BIOL MEO TRBMA 37. 197B {RECD 1979) 145-151 Coden: Descriptors: HUMAN CARCINOGEN AIR POLLUTANT CLEAN AIR ACT Concept Codes: GENL BIOL-INSTI TUT,ADM IN.LEG ISLN(* 00500); SOCIAL BIOL/I IUMAN ECOLOGY(05500); COMPARATIVE BIOCHEM-GENL SlUDIES( 10010): BIOCHEM-GASESf 10012): BIOCHEM STUD-GENERAL( 10- 060): TOXICOL-ENVIRONMNTL.I NOUS T R(* 2 2506); NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007); ENVIRON HEALTH-A IR.WATR.SL POLLN(*37015) BlosystematIc Codes: HOMINI DAE(862 15 ) 17O29G06 HEALTH EFFECTS OF VINYL CHLORIDE TAMBURRO C H TEX REP BIOL MED 37. 1978 (RECD 1979) 126*143 Coden: TRBMA Descriptors: ANIMAL HUMAN LIVER TUMORS CARCINOGEN ANESTHETIC ENVIRONMENTAL EXPOSURE DIAGNOSIS Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(*02506): CYTOLOGY/C- YTOCHEM-HUMANf*02508); SOCIAL BIOL/HUMAN ECOLOGY(05500): BIOCHEM STUD-GENERAU10060); PATHOLOGY - 01AGNOSTIC( 12504 ); PATHOLOGY-THERAPYC12512); DIGESTIVE SYST-GENL STUDS.METHS(140- 01): DIGESTIVE SYST-PATHOLOGY(* 14006); NERVOUS SYST-GENL STUDS.METHS(20501); PHARMACOL-CLINI CAL PHARMACOL(22005); PHARMACOL'NEIJROPHARMACOLOGYC *22024); TOXICOL-PHARMACOLOGICAL(*22504); TOXICOL-ENVIRONMNIL.INDUSTR(*22506): NEOPLSMS/NEOPL AGNT S-DI A - GNS METlK *24001): NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(*24007 ) ; ENVIRON IIEALTH-OCCUPATNL HEALTH(37013) BlosystematIc Codes: MAMMAL I A-UNSPECIFI ED AND EXT I NOT(8 5700) -, HOM INIDAE(86215) 17028726 POPULATION EXPOSURE TO TOXIC SUBSTANCES USE OF 1970 CENSUS DATA LANDAU E: CONIGL10 W J.A1R POLLUT CONTROL ASSOC 29 (3). 1979 249-251 Coden: JPCAA Descriptors: HUMAN VINYL CHLORIDE INDUSTRIAL POLLUTANT Concept Codes: ECOLOGY-B10CL1MATOL.BIOMETEOROL(*07504); BIOCHEM STUD-GENERAL( 10060); TOXI COL-ENVIRONMNTL,INDUSTR(*225- 06); PUB HEAL TH-ADMINISTR,STATISTICS(*37010): HEALTH-AIR.WATR.SL POLLN(*37015) ENVIRON B losystemat(c Codes: HOMINIOAE(B6215) 17020154 . POLY VINYL CHLORIDE PYROLYSIS PRODUCTS AS A CAUSE OF SMALL AIRWAY DYS FUNCTION IN MEAT WRAPPERS ASTHMA SCHWARTZ H J: PRESTEL T F JR; CHESTER E H: TUTHILL T M; BARANCIK G; BOZICH T J ALLERGY CLIN IMMUNOL 63 (3). 1979 152 Coden: JACIB Descriptors: ABSTRACT HUMAN Concept Codes: BIOCHEM-GASES(10012): EXTERN EFF-HOT(1061B); RESPIRATORY SYST-PATHOLOGY(* 16006); TOXI COL-ENVIRONMNTL.INOUSTR(*22506): TEMPERATURE-GENL.METHS(23001); IMMUNOL/IMMUNOCHEM-IMMUNOPATIIOL(*34508); ALLERGY(*35500); ENVIRON IIEALTH-OCCUPA TNL HEALTIK *37013) U I or.ys teina t I c Codes: MOM I NI OAE ( 862 1 5 ) DIALOG F(le5: BIOSIS Prev 1 ews. 77 - 83/Jan BA7502;RRM24Q2(See FI1e55) R&s 13851$ (c. B1 ijj, _ if 858) User 3614 25Jan83 2 16 1 17027801 CHLOROPRENE 2 CHLORO-1 3 BUTADIENE WHAT IS THE EVIDENCE FOR ITS CARCINOGENICITY HALEY T J WINER. CHARLES L. AND SYDNEY P. SHANOR (ED.). TOXICOLOGY ANNUAL. VOL. 3. XII+340P. ILLUS. MARCEL DEKKER, INC.: NEW YORK, N.Y.. USA; BASEL, SWITZERLAND. 1979 153-170 Coden: 07223 ISBN O-0247 - 6773 - X. Descriptors: HUMAN RAT MOUSE NERVOUS SYSTFM VINYL CHLORIDE CARCINOGEN OCCUPATIONAL EXPOSURE MIXEO FUNCTION OXIDASE NERVOUS SYSTEM EFFECTS LUNG CANCER SKIN CANCER DENTAL EFFECTS Concept Codes: COMPARATIVE BIOCHEM-GENL STUD IES( IO010): BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-PROTEI NS.PEPTIDES.A - MINO ACOC 10064); BIOPHYS-MOLECUL PROP.MACROMOLEC( 10506): ENZYMES-PHYSIOLOGICAL STUDIES(*10808); METABOLISM-GENL STUD,METAB PATHW(* 13002): RESPIRATORY SYST-GENL STUD.METHS( 16 - OO 1 ) ; RESPIRATORY SYST-PATHOLOGY(*16006); INTEGUMENT SYST-GENL STUDS.METIISt 18501 ) : INTEGUMENT S Y ST - P A THOLOC.Y ( *18506 ) ; DENTAL/ORAL BIOL-GENL STUD.METHS(19001); DENTAL/ORAL BIOL-PATHOLOGY(* 19006); NERVOUS SYST-GENL STUOS,METHS(2050 I); NERVOUS SYST-PATHOLOGY(*20506); ROUTES OF IMMUNIZ.INFECT.THER- AP(22100); T OX I COL -ENV1RONMNT L,INDUSTR(*22506); NEOPLSMS/NEOPL AGNT S - C ARC I NOGENS ( * 24 007 ) ; ENVIRON HF. AL TH-OCCUP A TNI. HE A LTN( 3 - 7013); EPIDEMIOL-ORGANIC DIS.NEOPLASMS(37054) Blosystemat1c Codes: HOMINIDAE(86215); MUR 1 DAE(06375) Concept Codes: GENET ICS/CYTOGENET-ANIMAL(*03506); ECOLOGY-W- ATR RESRCH.FISHERY BI0L(07517); BIOCHEM STUD-GENERAL(10060): TOXICOL-ENVIRONMNT L.INDUSTR(*22506); MICROORGANISMS-GENL.MIXED,UNSPEC(29500): ENVIRON HEALTH-A IR.W- ATR.SL POLLN(*37015) BlosystematIc Codes: MICROORGANISMS-UNSPECIFI ED(O1000); MAMMALIA-UNSPECIFIED AND EXTINCT(85700); MURIDAE(86375) 17018086 A WATER EXTRACTABLt TOXIC COMPOUND IN VINYL UPHOLSTERY FABRIC AHRENS V D: HENI ON J D; MAYLIN G A; LEI BOV IT Z L: ST JOHN L E JR: LISK D d BULL ENVIRON CONTAM TOXICOL BECTA 20 (3). 1978 418-422 Coden: Descriptors: CARASSI US-AURATUS POLY VINYL CHLORIDE TRI PHENYL PHOSPHATE NEUROLOGIC INTOXICATI ON HISTO PATHOLOGIC LESION DEATH Concept Codes: ECOLOGY-ANIMAL(*07 508) ; ECOLOGY-LIMNOLOGY(07 - 514); ECOLOGY-WATR RESRCH,FISHERY BI0L(07517); ANATOMY/HISTOL- -MICRO,ULTRAMICRSC(11108); PATHOLOGY-NECROSIS(12510): NERVOUS SYST-PATHOLOGY(*20506); TOXICOL-ENVIRONMNTL,INDUSTR(*22506) BlosystematIc Codes: OSTEICHTHYES(85206) 17027402 TRI CHLOROETHYLENE FELDMAN R G VINKEN, P. J. AND G. W. BRUYN (ED.). HANDBOOK OF CLINICAL NEUROLOGY. VOL. 36. INTOXICATIONS OF THE NERVOUS SYSTEM. PART 1. XII * 570P. ILLUS. ELSEVIER/NORTH-HOLLAND BIOMEDICAL PRESS: AMSTERDAM. THE NETHERLANDS; NEW YORK. N.Y.. USA. (DIST. IN THE USA BY ELSEVIER/NORTII - HOLLAND, INC.: NEW YORK. N.Y.) ISBN 0-7204-7236-9. 1979 457-464 Coden: 07183 Descriptors: HUMAN RAT GUINEA-PIG SENSATION LOSS PSYCHO PHYSIOLOGY NEUROPATHY INDUSTRIAL SOLVENT Concept Codes: BEHAVIOR BIOL-HUMAN BEIIAVI OR(07004); BIOCHEM STUD-GENERAU10060): PATHOLOGY-COMPARATIVE( 12503): MET ABOLISM- -GENL STUD,METAB PATHW ( 13002); NERVOUS SYST-PA 11IOLOGY(* 20506): PSYCHIATRY-PSYCHPATH-DYNM.THERAP(*21002): PSYCHIATRY-PSYCHOPHYSIOLOGY(21003); TOXICOL-ENVIRONMNTL.INDUSTR(*22506) Blosystemat1c Codes: MUR I DAE(86375 ) HOMINI DAE ( 862 I 5); CAVI I DAE(86300); 17009459 MAINTENANCE OF PERMANENTLY IMPLANTED CARDIAC PRESSURE CATHETERS IN EXPERIMENTAL ANIMALS CHITWOOD W R JR; HILL R C; WECH5LER A S ANN THORAC SURG 26 (5). 1978 4B5-4B8 Coden: ATIISA Descriptors: DOG HEPARIN ANTICOAGULANT THROMUOSIS POLY VINYL CHLORIDE THORACOTOMY Concept Codes: BIOCHEM STUD-GENERAL( 10060); BIOCHEM S1UD-CARB0HYDR.(10068); BIOPHYS-GENERAL BIOPHYS TECH(10504); BIOPHYS-BIOENGINEERING(10511); AN ATOMY/II ISTOL-EXPERIMENTAL( * 1 1 104 ) ; CIIORDATE BODY REGNS-TMOR- AX( 1 13 12); PHYSIOLOGY-INSTRUMENTATIDN( 12004); CARDIOVASC SYST-GENL STUDS.METIISt* 14501 ) : CARDIOVASC SYST-BLD VESS PATIIOL(14508); PHARMACOL-BLOOD.HEMATO AGENIS(22008); PHARMAC OL -CARD I OVASC SYST(22010) B losys teina t tc Codes: CANIDAE (85765 ) 17021875 HYGIENIC ASSESSMENT OF FILMS INTENDED FOR HYDRO INSULATION OF ASSEMBLY LINE SWIMMING POOLS KYPYROV V N; KAPLINA T V; GAKAL R K; VINARSKAYA E I; STARCIIENKO S N; KONOVALOV V S: KOLESNIKOV M M GIG SANIT (5). 1978 91-93 Codon: GISAA Descriptors: MICRO FLORA RAT WARM BLOODED ANIMAL POLY VINYL i'll! noHH- nrnejir Ftcrrr watcd rm a t t v DIAL0<^Wle5: BIOSIS Previews 77-03/Jan B A7502 ; RRM2402 ( See F11e55) (c. BIOSIS 198 A3B&a6 _/ User 3614 25J an83 2 162 17008652 THE IMPORTANCE OF NONLINEAR DOSE DEPENDENT PHARMACO KINETICS IN HAZARD ASSESSMENT WATANABE P G; YOUNG J D; GEHRING P J J ENVIRON PATHOL TOXICOL 1 (2). RECD 1977 147-159 COden: dEPTD Descriptors: RAT HUMAN VINYL CHLORIDE CARCINOGEN EXPOSURE HAZARD BIO TRANSFORMATION EXCRETION PROTEIN BINDING concept Codes: MATHEMATIC BIOL/STATISTIC METH(0450O); SOCIAL BIOL/HUMAN ECOLOGY(05500); COMPARATIVE BIOCHEM-GENL STUOIES(10010); BIOCHEM STUD-GENERAL(10060): BIOCHEM STUD-PROTEINS,PEPTIDES,AMINO ACD(10064); PHYSIOLOGY-COMPARATI - VE(12003); METABOLISM-GENL STUD.METAB PATHWf13002); METABOLISM-PROTNS.PEPTDS.AM ACDS( 1 3012): URIN SYST/EXT SECR-PATHOLOGY(15506); T0X1C0L-GENL/EXP STUDS.METHS(*22501); TOXICOL-ENVIRONMNTL.INDUSTR(* 22506); NEOPLSM5/NEOPL AGNTS-BIO- CHEM(*24006); NEOPLSMS/NEOPL AGNTS-CARC 1 NOGENS(24007 ); ENVIRON HEALTH-AIR.WATR.SL POLLN(37015) B losystem.it Ic Codes: MAMMAL IA-UNSPEC I F I ED AMD EXT INCT ( 85700 ) ; HOMINIDAE(862 15) ; MUR I DAE(86375) 1700B348 METABOLIC ACTIVATION AND DISPOSITION OF VINYL CHLORIDE IN-VIVO AND IN-VITRO BOLT H M; LAIB R J; FILSER J d ENVIRON PATHOL TOXICOL 2 (1). 1978 221 Coden: JEPTD Descriptors: ADENYLIC-ACID ABSTRACT RAT LIVER CARCINOGEN NADPH POLY Concept Codes: BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-NUCL ACD.PURNS,PYRM( 10062); ENZYMES-GEN.COMPAR STUD.COEN- ZYMS(* 10802 ) ; METABOLISM-GENL STUD.METAB PATHWf 13002): DIGESTIVE SYST-PHYSIOL,BIOCHEM(* 14004); TOXI COL-GENL/EXP STUDS.METHSt*22501); NEOPLSMS/NEOPL AGNTS-BI0C1IEM( * 24006); NEOPLSMS/NEOPL AGNTS-CARCINOGENSC* 24007); IN VITRO STUDS-CELLULR.SUBCELL(32600) B I osys t etna t I c Codes: MUR I DAE { 86375 ) 1700692G VINYL CHLORIDE DISEASE JOHNSTON E N M BR J DERMATOL SUPPL 99 (16). 1978 45-48 Coden: BJDSA Descriptors: ABSTRACT HUMAN RAYNAUDS PHENOMENON IMMUNE COMPLEX VASCULITIS COMPLEMENT C-3 IMMUNO GLOBULIN G OCCUPATIONAL HAZARD Concept Codes; BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-PROTEINS.PEPTIDES,AMINO ACD(10064); BIOCHEM STUD-CARBOHY- DR. (100GB); CARD 1OVASC SYST-OLD VESS PATHOL(* 1450B); BLOOD/BODY FLDS-BLOOD.LYMPH STUD( 15002); NERVOUS SYST-PATIIOLO- GY(* 20506); 1DXI COL-ENVIRONMNTL.1NDUSTR( *2 2506); IMMUNOL/IMMU- NOCHEM-IMMUNOPATIIOL(*34508); ALLERGY(35500): ENVIRON HEALTH-OCCURAT NL HEALTH{* 370 I 3) Blosys1emat 1c Codes: HOMINIDAE(86215) 17004007 FACTOR-VI11 CONTENT AS EVIDENCE FOR ENDOTHELIAL ORIGIN OF VINYL CHLORIDE ASSOCIATED LIVER ANGIO SARCOMA FORTWENGLER H P; JONES 0; TAMBURRO C H: ESPINOSA E FED PROC 38 (3 PART 1). 1979 999 Coden: FEPRA Descriptors: ABSTRACT IMMUNO FLUORESCENCE concept Codes: MICROSCOPY-HISTOL,HISTOCHEM TECH(0105G); CYTOLOGY/CYTOCHEM-ANIMAL(02506); BIOCHEM STUD - GENERAL(10060); BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACD(10064); DIGESTIVE SYST -GENL STUDS.METHS( 14001 )`. DIGESTIVE SYST - PATHOLOGY ( 1 4006 ) : CARD IOVASC SYST-BLD VESS PATHOL(* 14508); BLOOD/BODY FLDS-BLOOD.LYMPH STUD(*t5002); BLOOD/BODY FLDS-LYMPHAT TISS.RES( 15008); TOXI COL-GENL/EXP STUDS.METHS(*22501): NEOPLSMS/NEDPL AGNTS-CELL LINE(24005); NEOPLSMS/NEOPL AGNTS-BIOCHEM(*24006); NEOPLSMS/NEOPL AGNTS-CARCTNOGENS(2400- 7); IMMUNOL/IMMUNOCHEM-GEN METH(34502) B losystemat1c Codes; VERTEBRATA-UNSPECIFI ED(85150) 1 7004076 REACTIVITY OF HUMAN ALPHA THROMBIN ADSORBED ON ARTIFICIAL SURFACES CtlUANG H Y K; MOHAMMAD S F; SHARMA N C: MASON R G FED PROC 38 (3 PART 1). 1979 997 Coden: FEPRA Descriptors: ABSTRACT GLASS CUPROPHANE POLY VINYL CHLORIDE CLOTTING ACTIVITY ESTERASE ACTIVITY ANTI THROMBIN ANTIBODY IMMUNO GLOBULIN G Concept Codes: CYTOLOGY/CYTOCHEM-HUMAN(02508); RADIATION BIOL-RADTN,ISOTOP TCH(06504); BIOCHEM STUD-PROTEI NS.PEPTIDES- .AMINO ACD( 10064); ENZYMES-PHYSIOLOGICAL STUD IES(*10808); BLOOD/BODY FLDS-BLOOD FLDS-BLOOD.LYMPH STUD(*15002); BLOOD/BODY CELL STUDS(15004); 1MMUNOL/IMMUNOCHEM-GEN METlH *34 502); IMMUNOL/IMMUNOCHEM-IMMUNOHEMATOL(34506 ) B I osys tenia t 1 c Codes: HOMINI DAE ( 862 15 ) 17001129 A TERATOLOGIC EVALUATION OF PLASMA SOLUBLE EXTRACTS OF POLY VINYL CHLORIDE PLASTICS IN RATS CHEN T S: FERNANDES J; LEWANOOWSKI M FED PROC 3B (3 PART 1). 1979 438 Coden: FEPRA Descriptors: ABSTRACT GROSS EXTERNAL SKELETAL VISCERAL DEFECTS PL-130 PL-146 DI ETHYLHEXYL PHTHALATE Concept Codes: BIOCHEM STUO-GENERAL( 10060) ; PA THOLOGY-GF.NER- AL STUDIES! 12502); BONE,JNIS.FASC.CONN/AO IP-PA I MOL( 18006 ) ; TOXICOL-GENL/EXP STUDS,METHS!22501); DEVELOPMNTL BIOL-PATMOL- OGICAL(*25503); DEVELOPMNTL BIOL-EXPER TERATOL(25554 ) B 1 osys t ema t I c Cories: MUR I DAE ( 86375 ) DIALOG M1e5: BIOSIS PrevIews. 77-83/Jan BA7502;RRM2402(See F11e55) Cc. BIOSIS 1982) (It R&S 138517 614 25Jan83 2 1G3 16059797 WATERBORNE DISEASE CURRENT THREAT COOPER R C GROUND WATER 17 (2). 1979 192-196 Coden: GRWAA Descriptors: ESCHERI CHI A-COL I VIRUS MAN MORTALITY INFECTIOUS DISEASE CANCER ASBESTOS VINYL CHLORIDE DIELDRIN HEPTACHLOR DOT LINDANE INSECTICIDE CHLOROFORM TRI CI1L0R0 ETHYLENE DRINKING WATER TREATMENT Concept Codes: ECOLOGY-OCEANOGRAPHY,LIMNOLOGY(*07510): ECOLOGY-LIMNOLOGY(07514): ECOLOGY-WATR RESRCH.FISHERY BI0L(O7- 517); BIOCHEM STUD-GENERAL(10060): MINERALS( 10069); B I OPHYS-BIOENGINEER ING( 10511); PATHOLOGY-NECROSIS( 12510); TOX ICOL - ENVI RONMNTL , INDUSTR ( *22506 ) ; NEOPLSMS/NEOPL AC.NT S - CARCIN OGENS (24007); MED/CLIN MICROBIOL-BACTERIOLOGY(36002); MED/CLIN MICROBIOL-VIROLOGY(+36006); PUB HEALTH-GENL.MlSCELL(- *37001): ENVIRON HEALTH-SEWG DISP.SANITAR( *37014 ): ENVIRON HEALTH-AIR.'WATR.SL POLLN( *37015) ; EP 10EM1 OL - COMMUNIC ABL E OISEASES(37052): PUB HEALTH-INANIMATE DIS VECIORS(*37060): PUB HEALTH MICROBIOL(37400); PEST CONTRL GENL/PESI IC5/MERBICS(* 54 - 600); ECONOM ENTOMOL-CHEM PHYS CONTRL(6001G) BlosystematIc Codes: MICROORGANISMS-UNSPECIFI ED(01000); ANIMAL VI RUSE5-UNSPECIFI ED(02 200); ENTEROBACTERI ACEAE(04810): HOMINIDAE(86215); ABSTRACTS OF ENTOMOLOGY(96000) 16058095 ANALYSIS OF FOOD SAXBY M J LENIHAN, JOHN ANO WILLIAM W. FLETCHER (ED.). ENVIRONMENT AND MAN, VOL. 7. MEASURING AND MONITORING THE ENVIRONMENT. XII+131P. ILLUS. ACADEMIC PRESS. INC.: NEW YORK. N.Y.. USA. ISBN 0-12-443507-6. 1978 (RECD 1979) 14-36 Coden; 07128 Descriptors: FOOD ADDITIVES MYCO TOXIN INSECTICIDE HERBICIDE FUNGICIDE FUMIGANT POLY CHLORINATED BI PHENYL METAL POLY CHLORO DI BENZO-P-DIOXIN VINYL CHLORIOE NI TROSAMINE S CARCINOGENS Concept Codes: BIOCHEM-GASES( 10012); BIOCHFM METH-GENERAL(* - 10050); BIOCHEM METH-MINERALS(*10059): BIOCHEM STUD-GENERAL( 1- 0060); MINERALS( 10069); FOOD TECII-GENL STUOS,METHS(* 13502): FOOD TECH-EVALNS PHYS.CHEM PROPS(* 13530); FOOD TECH-SYNTH.SUPPL,ENRICH FDS(*13534); TOXI COL-FOOD.RESIDS.ADD I T.PRESRV(*22502 ) ; TOXI COL-ENVIRONMNTL.INOUSTR(22506); NEOPLS MS/NEOPL AGNT S-CARC I NOGENS(24007); MED/CLIN MICROBIOL-MYCOLOG- Y( *36008); F00D/1NDUS MICRO-FD/BEV SP CNTAM(39002): PI ANT PHYSIOL-GROWTH SUBSTANCES(51514); AGRONOMY-WEEDS AND WEED CONTROL(52518); PEST CONTRL GENL/PESTICS/l IERBICS(* 54600): ECONOM ENTOMOL-CHEM PHYS CONTRL(60016) B losys toiu.it Ic Codes; 0RC.ANI SMS-UNSPEC I F I ED ( 00500 ) ; FUNGI-UN- SPECIFIEDI 15000): ABSTRACTS OF MYCOLOGY(95000); ABSTRACTS OF ENTOMOLOGY(9GOOO) GIG TR PROF ZABOL (1). 1978 23-27 Coden: GTPZA Descriptors: NERVOUS PROBLEM HISTAMINE CATECHOLAMINE CALCIUM POTASSIUM ION ACETYL CHOLINE CHOLIN ESTERASE SEROTONIN 8L000 Concept Codes: CLIN BIOCHEM-GENL STUDIES(10006); BIOCHEM STUD-GENERAL( 10060); BIOCHEM STUD-PROTEI NS.PEPT10ES,AMI NO ACO( 10064); MINERALS( 100G9); BIOPHY$-MOLECUL PROP.MACROMOLEC(- 10506); ENZYME S- PHY SIOLOGI CAL STUDIES( 10808); METABOLISM-GENL STUD,METAB PATHW( 13002); MINERALS(13010): METABOLISM-PROTNS.P- EPTDS.AM ACOS( 13012); BLOOD/BOOY FLDS-BLOOD.LYMPH STUD( 15002); NERVOUS SYST-PATHOLOGY(*20506): TOXICOL-GENL/EXP STUDS.METHS(- *22501); TOXICOL-ENVIRONMNTL.INDUSTR(22506) BlosystematIc Codes; HOMINIDAE(86215) 16054523 SCANNING ELECTRON MICROSCOPIC OBSERVATIONS OF FORMED BLOOD ELEMENTS ON PLASTIC SURFACES WILKINSON R F J CELL BIOL 75 (2 PART 2). 1977 412A Coden; JCLBA Descriptors: ABSTRACT HUMAN ERYTHROCYTES LEUKOCYTES PLATELETS EXTRACORPOREAL CIRCULATION POLY VINYL CHLORIDE TUBING POLY URETHANE THROMBOGENIC POTENTIAL Concept Codes; CYT0L0GY/CYT0CHEM-HUMAN(02508); BIOCHEM 5TUD-GENERAL( 10060): BIOPHYS-BIOENGINEERING(* 1051 1): CARDIOVA- SC SYST-GENL STUDS.METHS(14501); BLOOD/BODY FLDS-BLOOD.LYMPH STUD(15002); BLOOD/BODY FLDS-BLOOD CELL STUDS(15004); BLOOO/BODY FLOS-BLD.LYM.RES PATH(* 15006); BLOOD/BODY FLDS-LYMPHAT TISS.RES(* 1 5008) Blosystematfc Codes; HOMINIDAE(B6215) 1604 8951 THE USE OF PARITY SURVIVORSHIP ANALYSIS IN THE STUDY OF REPRODUCTIVE OUTCOME DOBBINS J G; EIFLER C W; BUFFLER P A AM J EPIDEMIOL 108 (3). 1978 245 Coden: AJEPA Descriptors: ABSTRACT HUMAN VINYL CHLORIDE CARCINOGEN MUIAGEN TERATOGEN LIFE TABLE ANALYSIS Concept Codes: GENETICS/CYTOGENET-I IUMAN(*03508): MATHEMATIC BIOL/STATISTIC METH(04500); SOCIAL BIOL/HUMAN ECOLOGY(05500): PATHOLOGY-NECROSIS( 125 10); REPRODUCT SYST-PATHOLOGY( 16506 ) ; TOXICOL-GENL/EXP STUDS.METHS(*22501); NEOPLSMS/NEOPL AGNTS-CA- RCINOGENS( *24007); OEVELOPMNTL BIOL-PATHOLOGI CAL( * 25503 ) ; DEVF.LOPMNTL BI0L-DESCR1P TERATOU *25552 ) ; PUB HEALTH-admINIST- R.STATIST ICS(37010): ENVIRON HEALTH-OCCUPATNL HEALTH(37013 ) B losystemattc Codes; HOMINIDAE!B6215) 16055149 NEURO HUMORAL INTERRELATIONSHIPS VINYL CHLORIDE POISONING mn runt A crh* nv a r a IN PATIENTS WITH CHRONIC DI ALO e5 : BI05IS Previews 77-83/Jan BA7502 : RRM2402 C See 16048950 BIRTH DEFECTS MONITORS CAN THEY ANSWER THE RIGHT QUESTIONS HARLAP S AM J EPIDEMIOL 108 (3). 1978 245 Codon: AJEPA Descriptors: ABSTRACT HUMAN SEX HORMONE VINYL CHLORIDE INFECTION EPIDEMIOLOGY TERATOGENESI S Concept Codes: GENET ICS/CYTOGENET-SEX 01FFERENC(03510); PHYSICAL ANTHROPOLOGY/ETHNOBIOL(05000): SOCIAL BIOL/HUMAN ECOLOGY(05500); BIOCHEM STUD - STEROLS.STEROIDSI 10067); PATHOLO GY -01AGNOSTIC( 12504); METABOLISM-STEROLS.STEROIDS( 13008); END OCRINE SY ST - GONADS,PLAC ENT A(* 17006); TOXI COL-GENL/EXP STUDS.M- ETHSt*22501); PEOI ATRICS(25000): DEVELOPMNTL BIOL-DESCRIP TERATOL(*25552 ) ; MED/CL IN MICROBIOL-GEN.METH.TECH(36001); PUB HEALTH-HEALTH SERV.MEDL CARE(370 12); CPIDEMI0L-M1SCELL STUDIE5(37056) Blosystemat1c Codes: MICROORGANISMS-UN5PECIFIEO(01000); MOMINIDAE(86215) 16048855 ENVIRONMENTAL SOURCES OF CHEMICAL MUTAGENS PART 2 SYNTHETIC MUTAGENS FISHBEIN L FLAMM, W. GARY AND MyRON A. MEMLMAN (ED.). ADVANCES IN MODERN TOXICOLOGY. VOL. 5. MUTAGENESIS. XII+401P. ILLUS. HEMISPHERE PUBLISHING CORPORATION: WASHINGTON. D.C., USA; LONDON. ENGLAND (DIST. BY HALSTED PRESS/WILEY & SONS. INC.: NEW YORK. N.Y.. USA.). ISBN 0-470-99393-6. 1978 257-348 Coden: 06983 Descriptors: REVIEW HUMAN HALOGENATED HYDRO CARBON VINYL CHLORIDE VINYLIDENE CHLORIDE TR1 CHLORO ETHYLENE TETRA CHLORO ETHYLENE CHLOROPRENE CARBON TETRA CHLORIDE FLUORO CARBON POLY CHLORINATED BI PHENYLCHLORO DIOXIN HALO ETHER CHLORINE BROMO ALKANE FLUORINE DDT INSECTICIDES PHTHALATE ESTER ARSENIC LEAD MERCURY Concept Codes: CYTOLOGY/CYTOCHEM-HUMAN(*02508); GENET ICS/CY- TOGENET-HUMAN(*03508); BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-NUCL AGO.PURNS.PYRMf10062): MINERALS(10069); METABOLISM-- NUCL ACD.PURINS.PYRIM(* 13014); TOXICOL-GENL/EXP STUDS,METHS(2 - 2501); TOXICOL-E NVIRONMNTL,INDUSTR ( *22506); ENVI RON HEALTH-A I- R.WATR.SL POLLN(*37015); PEST CONTRL GENL/PESTICS/HERBICS(546- GO); ECONOM ENTOMOL-CHEM PHYS CONTRL(600 16) Blosystemat1c Codes: HOMINIDAE(86215); ABSTRACTS OF ENTOMOLOGY(96000) 16048850 THE SALMONELLA MICROSOME MUTAGENICITY TEST PREDICTIVE VALUE TOR ANIMAL CARCINOGENICITY MCCANN J; AMES B N FLAMM. W,' GARY AND MYRON A. MEIll.MAN (ED.). ADVANCES IN MDDERN TOXICOLOGY. VOL. 5. MUTAGENESIS. XIIM01P. ILLUS. HEMISPHERE PUBLISHING CORPORATION: WASHINGTON. D.C.. USA; LONDON. ENGLANO (DIST. BY HALSTED PRESS/WILEY ft SONS. INC.: NEW YORK. N.Y., USA.).. ISBN 0-470-99393-6. 1978 87-108 Coden: 06983 (c. BIOSIS 1982) CIt R&S 138518 l4 25Jan83 2 164 Descriptors: HUMAN DMA AFLA TOXIN B-1 VINYL CHLORIDE ASBESTOS CHLOROPRENE COAL TAR CARCINOGENS Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506): CYTOLOGY/CY- TOCME M-HUMAN(02508); GENET 1CS/CYTOGENET-ANIMAL(03506 ) ; GENET- ICS/CYTOGENET-HUMAN(*03508); BIOCHEM STUD-GENERAL(10060): BIOCHEM STUD-NUCL ACD.PURNS.PYRM(10062); MINERALS(10069); ME T ABOLISM-NUCL ACD.PUR I NS.PYRIM(13014); TOXI COL-GENL/EXP STUDS.METHS(*22501); TOXICOL-ENVIRONMNTL.1NDUSTR(*22506); NEO- PLSMS/NEOPL AGNTS-BIOCHEM(*24006); NEOPLSMS/NEOPL AGNTS-CARCI - NOGENSt*24007); BACTERIAL AND VIRAL GENET ICS(* 31500); MICROBIOLOG APPARAT.METHS.MED I A(32000); IN VITRO STUDS-CELLUL- R.SUBCELL(32600); MED/CL IN MICROBIOL-MYCOLOGY(*36008); ENVIRON HEALTI1-0CCUPATNL HEALTH(*37013) B losystematIc Codes: ENTEROBACTERI ACEAE(04810): DEUTEROMYCE- TES( 15500): AN I MAH A-UNSPECIFI ED(33000): HOMINIDAE(862 1 5) 16047306 HYGIENIC EVALUATION OF WORK CONDITIONS OF WORKERS DURING THE WELDING OF POLY VINYL CHLORIDE LINOLEUM FLOOR COVERING WITH THE SEMI AUTOMATIC PCHELKA KRAEV B G GIG TR PROF ZABOL GTPZA 12, 1977 (RECO 1978) 43-44 Coden: Descriptors: USSR HUMAN AIR TOXIC SUBSTANCES VENTILATION Concept Codes: BIOCHEM-GASES(10012); BIOCHEM STUD-GENERAl. ( 1 - 0060): RESP1RATDRY SYST-GENL STUD.METHS( 1600 1 ); TOXICOL-ENVIR- ONMNTL.INDUSTR(*22506); ENVIRON HEALTH-OCCUPATNL HEALTH(* 3701- 3) Blosystematic Codes: HOMINIDAE(86215) 16047304 COMPARATIVE HYGIENIC EVALUATION OF WORK CONDITIONS IN PLASTER CASTING AND POLY VINYL CHLORIDE FROM SECTIONS OF THE DULEVO PORCELAIN FACTORY DUPLYANKIN S A GIG TR PROF ZABOL 12. 1977 (RECD 1978) 40-41 Coden: GTPZA Descriptors: USSR HUMAN DUST KEROSINE VAPOR Concept Codes: BIOCHEM-GASES( 100 12); BIOCHEM STUD-GENERAL{ 1 - 0060); TOXI COL -ENVIRONMNTL.INDUSTR( * 22506); ENVIRON HEALTH-OC CUPATNL I1EALT11( *37013) ; ENVIRON HE ALT H - A 1 R , WA T R . SL POLLN(37015) 8 losystomat1c Codes: HOMINIOAE(86215) DI ALO 1e5: BI OS IS Previews 77-B3/Jan BA7502;RRM2402(See FI 16046400 CONTRIBUTION TO THE DETECTION AND ASSAY OF VINYL CHLORIDE EVENTUALLY PRESENT IN AQUEOUS INJECTABLE SOLUTIONS CONTAINED IN VINYL POLY CHLORIDE BAGS ROLLET M; GUFEDIN A ANN PHARM FR 36 (3/4). 1978 169-177 Coden: APFRA Descriptors: CHROMATOGRAPHY DIRECT GAS CHROMATOGRAPHY GAS SOLID THERMO Concept Codes: COMPARATIVE BIOCHEM-GENL STUD IES( 10010); BIOCHEM METH-GENERAL(10050): BIOCHEM STUD-GENERAL(10060): BIOPHYS-GENERAL BIOPHYS TECH(10504); BIOPHYS-MOLECUL PROP.MACROMOLECf10506): MOVEMENT(12100); ROUTES OF IMMUNIZ.INFECT.THERAP(22100): TOXI COL-GENL/EXP STUDS,METHS(*22501) . 16044661 PATHOGENESIS OF CARDIO VASCULAR OYS FUNCTION IN CHRONIC VINYL CHLORIDE INTOXICATION KURL Y ANDSKI I B A; TOMI.LINA L A; DUKHOVNAYA A I; STOVBUR N N GIG SANIT (2). 1978 104-105 Coden: GISAA Descriptors: ALBINO RAT EPINEPHRINE PHUITRIN HORMONE-DRUG CARDIOVASCULAR-DRUG Concept Codes: GENETICS/CYT0GENET-ANIMAL(03506); BIOPHYS'GE- NERAL BIOPHYS TECH(10504); PATHOLOGY-DIAGNOSTIC ( 12504) ; CARD I OVA SC SYST-GENL STUDS.METHS( 14501); CARDIOVASC SYST-BLD VESS PATHOL(* 14508): ENDOCRINE SYST-ADRENALS(17004); ENDOCRINE SYST-NEUROENDOCRINOLOG(* 17020): NERVOUS SYST-PATHOl- OGY(*20506): PHARMACOL-CARDI OVASC SYST(* 22010); PHARMACOL - END- OCRINE SYST(*22016); TOXI COL-GENL/EXP STUDS.METHS('22501): TOXICOL-ENVIRONMNTL,INDUSTRf22506): NEOPLSMS/NEOPL AGNTS-CARC- INOGENS(24007) RlosystematIc Codes: MURIDAE(86375) 16043888 THE MUTAGENIC ACTIVITY OF HALOGENATED COMPOUNDS FOUND IN CHLORINATED DRINKING WATER SIMMON V F; TARDIFF R G JOLLEY. ROBERT L.. HEND GORCHEV AND 0. HEYWARD HAMILTON. JR. (ED.). WATER CHLORINATION. ENVIRONMENTAL IMPACT AND HEALTH EFFECTS. VOL. 2. PROCEEDINGS OF THE 2ND CONFERENCE. GATLINBURG, TENN.. USA. OCT. 31-NOV. 4. 1977. XVIII909P. ILEUS. MAPS. ANN ARBOR SCIENCE PUBLISHERS. INC.: ANN ARBOR. MICH.. USA. ISBN 0-250-40201-7. 1970 417-431 Coden: 06969 Descriptors: SALMONELLA-TYPHIMUR IUM RAT VINYL CHLORIDE VINYL IRENE CHLORIDE 1 2 DI CIll.ORO ETHANE I 1 2 TRI CIILORO ETHYLENE-BIS-2-CHLOROETHYL ETHER METHYL IODIDE BROMOTORM CARBON TETWA CHLORIDE CHLOROFORM CARCINOGENS Concept Codes: CYTOLOGY/CYTOCHM-ANIMAL(02506); GENE TICS/CY- TOGENE T-ANIMAL(*03506); ECOLOGY-LIMNOLOGY(*075 14): ECOLOGY-WA- TR RESRCH.FISHERY BI0L(07S17); BtOCHEM STUO-GENERAL(10060): MINERALS! 10069); BIOPHYS-MOLECUL PROP.MACROMOLEC( 10506); DENTAL/ORAL BIOL-GENL STUD.METHS(19001); ROUTES OF IMMUNIZ.INFECT,THERAP(22100): TOXI COL-GENL/EXP STUDS.METHS(*2- 2501): TOXICOL-ENVIRONMNTL.INDUSTRI*22506); NEOPLSMS/NEOPL (c. BIOSIS 1982) R&S 138519 er 3614 2Sjan83 2165 AGNTS-CARCINOGENS(*24007); BACTERIAL AND VIRAL GENETICS( * 3150- O): MICROBIOLOG APPARAT.METHS,MED I A(32000); ENVIRON HEALTH-A1R.WAIR.SL POLLNf*37015) BlosystematIc Codes: ENTEROBACTERI ACEAE(04 8IO): MUR IDAE(B63 - 75) 16040187 DE TOXIFICATION OF PESTICIDES AND HAZARDOUS WASTES BY THE MICROWAVE PLASMA PROCESS BAILIN L J: HERTZLER B L; OBERACKER D A KENNEDY. MAURICE V. (ED.). ACS (AMERICAN CHEMICAL SOCIETY) SYMPOSIUM SERIES. VOL. 73. DISPOSAL AND DECONTAMINATION OF PESTICIDES. A SYMPOSIUM AT THE 174TH MEETING OF THE AMERICAN CHEMICAL SOCIETY. CHICAGO. ILL.. AUG. 29-SEPT. 2. 1977. VII-U5BP. ILLUS. AMERICAN CHEMICAL SOCIETY: WASHINGTON, D.C.. USA. ISBN 0-8412-0443-0. 1978 49*72 Coden: 06794 Descriptors: NITROSAMINE VINYL CHLORIDE VINYLIDENE CHLORIOE CARCINOGEN MERCURY ARSENIC CADMIUM LEAD NERVE POISON Concept Codes: GENETICS/CYTOGENET-GENL STUD IES(03502 ) : RAO I A TION BIOL-RADTN,ISOTOP TECH(0G504 ); BIOCHEM METH-GENERAL- (10050): BIOCHEM STUD-GENERAL(*10060): NERVOUS SYST-PATHOLOGY- (20506); TOXICOL-GENL/EXP STUDS.METHS(*22501); TOXI COL-ENVIRO- NMNTL.INDUSTRf*22506); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(2400- 7); ENVIRON HEALTH-AIR.WATR,SL POLLNf370 15); PEST CONTRL GENL/PESTICS/HERBICS(*54600) B I osy s tenia t I c Codes: ORGANI SMS-UNSPECI F I ED (00500 ) 16039351 TERATOLOGIC EVALUATION OF VINYL CHLORIDE VINYLIDENE CHLORIDE AND STYRENE IN LABORATORY ANIMALS JOHN J A; MURRAY F J; SMITH F A; SCHWETZ B A TERATOLOGY 17 (2).. 1978 48A Codon: TJAOA Descriptors: ABSTRACT MOUSE RAT RABBIT INHALATION GAVAGE DRINKING WATER Concept Codes: BIOCHEM STUO-GENERAL(10060): NUTRIT1ON-GENL.- NUTR STATUS.METHS( 13202): DIGESTIVE SYST-GENL STUDS.METHS( 1 AO- 01); RESPIRATORY SYST-GENL STUD.METHS( 1 GOO 1); ROUTES OF IMMUNIZ, INFECT.THERAP(22100); TOXICOL-GENL/EXP STUDS.METUS( 22501): OEVE LOPMNTL BIOL-EXPER TERATOL(*25554 ) Blosystemat Ic Codes: LEPORI DAE(86040): MUR I DAE(86375 ) DIALOG^fcileB: BIOSIS Previews 77~83/Jnn BA7502;RRM2402 ( See Fll 16039228 EFFECTS OF PLASTIC POLYMER SURFACES ON THE LIQUID PRESERVATION OF HUMAN GRANULOCYTES CONTRERAS T J: JEMIONEK J F; FRENCH J E; SHfELDS L <J TRANSFUSION (PHILA) 18 (5). 197B 650-651 Coden: TRANA Descriptors: ABSTRACT POLYMORPHONUCLEAR CELLS GRAM NEGATIVE SEPTICEMIA TRANSFUSION POLY VINYL CHLORIDE Concept Codes: CYTOL0GY/CYTOCHEM-HUMAN(02508) : BIOCHEM STUD-GENERAL( 10060); PATHOLOGY - THERAPY(12512) ; BLOOD/BODY FLDS-GENL STUDS.METHS(15001); BLOOO/BODY FI.DS-BLOOD CELL STUDS ( * 1 5004 ) ; BLOOD/BODY FLDS-BLD , LYM . RES PATH( * 15006 ) ; BLOOD/BOOY FLOS-LYMPHAT TISS.RES(* 15008); MED/CLIN MICROBIOL-BACTERIOLOGY(36002) Blosystemat1c Codes: BACTERIA-UNSPECIFI ED(04000): HOMINIDAE- (862 15 ) (c. BIOSIS 1982) (Item 542 R&S 138520 2 1G6 PROCEEDINGS OF THE INTERNATIONAL CONGRESS u., THE HUMAN ENVIRONMENT (HESC). KYOTO. JAPAN. NOV. 17-26, 1975. XIV*99?P. ILLUS. MAPS. PERGAMON PRESS: NEW YORK. N.Y., USA; OXFORD, ENGLAND. ISBN 0-08-02194B-9. 1977 (RECD 1978) 496-504 Coden: 06445 Descriptors: HUMAN TRI CHLORO ETHYLENE TETRA CHLORO ETHYLENE VINYL CHLORIDE 1 2 DI CHLORO ETHANE PER CHLORO ETHYLENE 1 1 1 TRI CHLORO ETHANE CARBON TETRA CHLORIDE METHYLENE CHLORIDE METHYL CHLORIDE CHLOROFORM CARCINOGENS OCCUPATIONAL EXPOSURE METABOLIC TRANSFORMATION Concept Codes: SOCIAL BIOL/HUMAN ECOLOGY(05500): BIOCHEM STUD-GENERAL(10060): METABOLISM-GENL STUD.METAB PATHW(* 13002 ) ; TOXICOL-ENVIRONMNTL,INDUSTR(*22506); NEOPLSMS/NEOPL AGNTS-BIO- CIIEMt*24006); NEOPLSMS/NEOPL AGNTS-CARC1 NOGENS(24007); ENVIRON HEALT H-OCCUPATNL HEALTH(37013) BlosystematIc Codes: HOMINIDAE(862 15 ) 16039179 IN-VITRO FUNCTION AND IN-VIVO VIABILITY OF STORED PLATELET CONCENTRATES THE EFFECT OF A STABILIZER COMPONENT OF POLY VINYL CHLORIDE STORAGE BAGS . LINDBERG J E: CARMEN R A; SCHROEDER D D; NELSON E J TRANSFUSION (PHILA) 18 (5). 1978 634-635 Coden: TRANA Descriptors: ABSTRACT TETRA HYDRO FURFURYL OLEATE Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506); BIOCHEM 5TUD-GENERAL(10060); BLOOD/BODY FLDS-GENL STUOS,METHS(15001); BLOOD/BODY FLDS-BLOOD CELL STUDS(*15004) BIosys temat1c Codes: VERTEBRATA-UNSPECIFI ED(85150) 16026728 INHALATION CARCINOGENESIS NELSON N FUKUSHIMA. YOI CHI (ED.). SCIENCE FOR BETTER ENVIRONMENT. PROCEEDINGS OF THE INTERNATIONAL CONGRESS ON THE HUMAN ENVIRONMENT (HESC). KYOTO. JAPAN, NOV. 17-26, 1975. XIV+992P. ILLUS. MAPS. PERGAMON PRESS: NEW YORK. N.Y.. USA; OXFORD. ENGLAND. ISBN 0-08-021948-9. 1977 (RECD 1978) 505-510 Coden: 06445 Descriptors: HUMAN BENZENE NICKEL CARBONYL MUSTARD GAS VINYL CHLORIDE CHLOROPRENE BIS CHLOROMETHYL ETHER CARCINOGENS AIR POLLUTION OCCUPATIONAL EXPOSURE LUNG CANCER Concept Codes: SOCIAL BIOL/HUMAN ECOLOGY(05500): BIOCHEM-GASES( 10012); BIOCHEM STUD-GENERAL(10060): MINERALS(.1 - 0069); RESPIRATORY SYST-PHYSIOL.BIOCHEM(16004); RESPIRATORY SYST-PATHOLOGY(* 16006); TOXICOL-ENVIRONMNTL.INDUSTR(*22506): NEOPLSMS/NEOPL AGNTS-CARC INDGENS(24007); ENVIRON HEALTH-OCCU- PATNL HEALTH( *37013) : ENVIRON HE AI.TII - A IR . WATR . SL POL LN ( * 370 15 ) BIosys tema t1c Codes: H0M1NIDAE(862 15 ) 16026726 PROBLEMS IN THE INTERPRETATION OF LIVER NODULES STERNBERG S S FUKUSHIMA. YOI CHI (ED.). SCIENCE FOR BETTER ENVIRONMENT. PROCEEDINGS OF THE INTERNATIONAL CONGRESS ON THE HUMAN ENVIRONMENT (HESC). KYOTO. JAPAN. NOV. 17-26. 1975. XIV+992P. ILLUS. I4APS. PERGAMON PRESS: NEW YORK. N.Y.. USA; OXFORD. ENGLAND. ISBN 0-08-021948-9. Coden: 06445 1977 (RECO 197B) 494-495 Descriptors: HUMAN ARSENIC MINERAL OIL BETA NAPHTt IYLAM INE BENZIDINE ASBESTOS CHROMATE PHENACETIN THOROTRAST VINYL CHLORIDE CARCINOGENS SKIN BLADDER RENAL LUNG TUMORS Concept Codes: SOCIAL BIOL/HUMAN ECOLOGY(05500); RADIATION BIOL-RADTN. ISOTOP TECH(O6504); RAO I AT I ON BIOL-RAQTN EFF,PROTECT(*0G5O6): BIOCHEM STUD-GENERAL(10060): BIOCHEM STUD -LIPIDS( 10066): MINERALS! 10069); PATHOLOGY - THERAPY( 12512); DIGESTIVE SYST-PATIIOLOGY(* 14006); URIN SYST/EXT SECR-PATHOLOG- Y(*15506); RESPIRATORY SYST-PATHOLOGY(*1GOOG); INTEGUMENT SYST-PATH01.0GY( * 18506) ; PHARMACOL-GENERAL STUD I E S ( 22002 ) ; PHARMACOL-CLINICAL PHARMACOL(22005); TOXI COL-PHARMACOLOGICAL( - *22504); TOXICOL-ENVIRONMNTL.INDUSTR(* 22506); NEOPLSMS/NEOPL AGNTS-CARCINOOENS(*24007); ENVIRON HEALTH-OCCUPATNL HEAL TH(* 3 - 7013); ENVIRON HE ALTH-A IR.WATR.SL POLLN(* 37015) BIosys tema tIc Codes: HOMINIDAE(86215) 16026727 TOXICOLOGY OF CHLORINATED SOLVENTS MENSCIILER D FUKUSHIMA. YOI CHI (ED.). SCIENCE FOR BFTrtR ENVIRONMENT. D I All S 138521 /s.77-83/dan BA7502:RRM2402(See F 1 le55 ) (c. BIOSIS 1982) (Item -547 of 858) User 3614 25)nn83 2 167 1 602A 84 2 THE INTERACTION BETWEEN FOODS AND PACKING `AND ITS SIGNIFICANCE FOR EUROPEAN LEGISLATION VOM BRUCK C G: ECKERT W R; FIGGE K; KOCH 0; RUDOLPH F B MITT GEB LEBENSMITTELUNTERS HYG 69 (1). 1978 20-41 Coden: MGLHA Descriptors: RUBBER POLY ETHYLENE POLY VINYL CHLORIDE POLY STYROL Concept Codes: GENL BIOL-INSTI TUT.ADMIN.LEG ISLN(*00508): BIOCHEM STUD-GENERAL( 10060)1 FOOD TECH-GENL STUDS.METHS(1350- 2); FOOD TECH-EVALNS PHYS.CHEM PROPS(* 13530): FOOD TECH-PREP.PROCESSNG.STORAGE(* 13532 ) ; , TOXICOL-FOOD.RESIDS,ADOIT.PRESRV(22502) 16023009 INVESTIGATIONS OF DI-2 ETHYLHEXYL PHTHALATE IN BLOOD PREPARATIONS STORED IN POLY VINYL CHLORIDE SACKS/ PICK J: BREUER K U: ZSDANSZKY-ENGE L; PINTER-KRAMER J ACTA PHARM HUNG 48 (5). 1978 230-235 Coden: APHGA Concept Codes: BIOCHEM METH-GENERAL(* 10050): BIOCHEM STUO-GENERAL(100G0); BLOOD/BODY FLDS-BLOOD,LYMPH STUD(*15002): PHARMACOL-BLOOD,HEMATO AGENTS(*22008) 16021475 CONFERENCE ON COMPARATIVE METABOLISM AND TOXICITY OF VINYL CHLORIDE RELATED COMPOUNDS OVERVIEW AND SUMMARY MURPHY S D ENVIRON HEALTH PERSPECT (21). 1977 (RECD 197B) 327-328 Coden: Evhpa Descriptors: HUMAN WORKERS ANIMAL MUTAGENS CARCINOGENS Concept Codes: GENL BIOL-SYMPOSI A.PROCDNGS.REVW(00520); GENETICS/CYTOGENET-ANIMAL(03506); GENETICS/CYTOGENET-HUMAN(*03508); SOCIAL BIOL/HUMAN EC0LOGY(O- 5500); COMPARATIVE BIOCHEM-GENL STUDIES(10010); BIOCHEM STUD-GENERAL(10060)1 METABOLISM-GENL STUD,METAB PATHW(13002); TOXICOL-GENL/EXP STUDS.METHS(*22501); TOXI COL-ENVIRONMNTL,IND- USTR(*22506); NEOPLSMS/NEOPL AGNTS-CARC1 NOGENS(*24007); ENVIRON HEALTH-OCCUPATNL HEALTH(* 370 I 3); ENVIRON HEALTH-A IR.W- ATR.SL POLLNt*37015) Blosystemat1c Codes: VERTEBRATA-UNSPECIFIEO(05150); HOMINID- AE{862 15) 16021468 MUTAGENIC AND CARCINOGENIC RISKS ASSOCIATED WITH HALOGENATED OLEFINS INTANTE P F ENVIRON HEALTH PERSPECT (21). 1977 (RECD 1978) 251-254 Coden: EVHPA Descriptors: MOUSE RAT HUMAN SALMONELLA-TYPHIMURIUM DROSOPHILA VINYL CHLORIDE VINYLIDENE CHLORIDE TRI CHLORO ElMYLTNE Afirnni y CARCINOGENS OCCUPATIONAL i* i** * ''iMpri'r EXPOSURE CHROMOSOMAL Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(*02506); GENETICS/C- YTOGENET-ANIMAU*03506); SOCIAL BIOL/HUMAN ECOLOGY(05500); BIOCHEM STUD-GENERAL(10060): BIOPHYS-MOLECUL PROP.MACROMOLEC(- 10506); `RESPIRATORY SYST-PATHOLOGY(* 16006): INTEGUMENT SYST-PATHOLOGY(18506): TOXICOL-GENL/EXP STUDS.METHS(22501 ) : TOXICOL-ENVIRONMNTL,INDUSTR(* 22506 ) ; NEOPLSMS/NEOPL AGNTS-CAR- CINOGENS(*24007); BACTERIAL AND VIRAL GENET ICS(* 31500): MICROBIOLOG APPARAT.METHS.MEOIA(32000); ENVIRON HEALTH-OCCUPA TNL HEALTH(*37013): INVERTB PHYSIOL-INSECTA-PATHOL(*64078) 0losysteroatIc Codes: ENTEROBACTERI ACEAE(048 10) : DIPTERA(753- 14 ) ;.HOMINI DAE(86215); MUR IDAE(86375) 16021453 EFFECT OF ETHANOL AND VINYL CHLORIDE ON THE INDUCTION OF LIVER TUMORS PRELIMINARY REPORT RADIKE M U; STEMMER K L: BROWN P G; LARSON E; BINGHAM E ENVIRON HEALTH PERSPECT (21). 1977 (RECD 1978) 153-155 Coden: EVHPA Descriptors: RAT CARCINOGENS ANGIO SARCOMA HEPATO CELLULAR CARCINOMA Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506): BIOCHEM STUD-CENERAL( 10060): OIGESTIVE SYST-PATHOLOGY(* 1400G); CARD IOVASC SYST-BLD VESS PATHOL(* 14508 ) ; BONE.UNTS.FASC.CONN/- ADIP-PATHOL( 18006): PSYCH IATRY-ADD ICTION(INC SMOKNG)(21004); TOXICOL-GENL/EXP STUDS.METHS( *22501 ) ; TOX I COL - F.NVI RONMNTL . IND:, USTR(22506): NEOPLSMS/NEOPL AGNT5-CARCIN0GENS(*24007); ENVIRON HEALTH-OCCUPATNL HEALTH(37013) B losystemat1c Codes: MUR I DAE(86375 ) 1602145 I DAMAGE TO HEPATIC CELLULAR MEMBRANES BY CHLORINATED OLEFINS WITH EMPHASIS ON SYNERGISM AND ANTAGONISM REYNOLDS E S; MOSLEN M T ENVIRON HEALTH PERSPECT (21). 1977 (RECD 1978) 137-147 Coden: EVHPA Descriptors: SPRAGUE DAWLEY RAT MITOCHONDRIA CHROMATIN TRI CHLORO ETHYLENE VINYL CHLORIDE PER CHLORO ETHYLENE 1 1 DI CHLORO ETHYLENE GLUTATHIONE CYTOCHROME P-450 Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(*02506): BIOCHEM SIUD-GENERALI 10060); BIOCHEM STUD-NUCL ACD.PURNS.PYRM( 10062 ) ; BIOCHEM STUD-PROTEINS,PEPTIDES.AMINO ACD(10064); BIOCHEM SIUD-PQRPHXRNS.RILE PIGM( 10065); BIOPHYS-MEMBRANE PI IE NOMENA(* - 10508); ENZYMES-GEN.COMPAR STUD.COENZYMS(10B02); DIGESTIVE SYST-ANATOMY( 14002 ) ; OIGESTIVE SYST-PATHOLOGY(1400G); TOXICOL-GENL/EXP STUDS.METHS(*22501) B1osystematIC Codes: MUR I DAE(86375) DIALO leS: BIOSIS Pr R&S 138522 :RRM2402(See FI 13??) (c. BIOSIS 1982) (Item 553 of 838) User 3614 25jan63 2 168 1602 1446 IRREVERSIBLE BINDING OF CHLORINATED ETIIYLENES TO MACRO MOLECULES BOLT H M; FILSER U G ENVIRON HEALTH PERSPECT Coden: E VHPA (21). 1977 (RECO 197B) 107*112 Descriptors: RAT RABBIT BOVINE ALBUMIN VINYL CHLORIDE TRI CHLORO ETHYLENE CARBON TETRA CHLORIDE CARCINOGENS Concept Codes: BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-NUCL ACD.PURNS.PYRM(10062); BIOPHYS-MOLECUL PROP.MACROMO- LEC(10506): METABOLISM-GENL STUO.METAB PATHW(*13002); METABOLISM-PROTNS.PEPTDS.AM ACOS(* 13012): TOXI COL-GENL/EXP STUDS.METHS(*22501): NEOPLSMS/NEOPL AGNTS-BIOCHEM(24006); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(*24007) Blosystemattc Codes: BOV I DAE(857 15); LEPORI DAE(86040): MURIDAE(86375) DIXON R L: WOODS J S ENVIRON HEALTH PERSPECT Coden: EVHPA (21). 1977 (RECD 1978) 25-32 Descriptors: MOUSE RAT MAMMARY GLAND LIVER LUNG KIDNEY DISEASES CARCINOMAS Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506); BIOCHEM STUO-GENERALt 10060); PATHOLOGY-GENERAL STUD IES( 12502): PATHOLOGY-INFLAMMATN.INFLAM DIS( 12500): PATHOLOGY-NECROSIS( 12- 510); DIGESTIVE SYST-PATHOLOGY(14006); BLOOD/BOOY FLOS-LYMPHAT TISS.RES( 15008): URIN SYST/EXT SECR-PATHOLOGY(* 1 - 5506); RESPIRATORY SYST - PATHOLOGY(*16006); REPRODUCT SYST-PATHOLOGY( 16506): TOXI COL-ENVIRONMNTL.INDUSTR(*22506) ; NEOPLSMS/NEOPL AGNTS-PATH.CL INIC(*24004); NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007); ENVIRON HEALTH-A IR.WATR.SL POLLN(-' 37015) B losystemat 1c Codes: MURIDAE(86375) 16021441 DOMINANT LETHAL STUDIES WITH THE HALOGENATED OLEFINS VINYL CHLORIDE AND VINYLIDENE DI CHLORIDE IN MALE CD-I MICE ANDERSON D; HODGE MCE; PURCHASE I F H ENVIRON HEALTH PERSPECT Coden: EVHPA (21). 1977 (RECD 1978) 71-70 Descriptors: ETHYL METHANESULFONATE CYCLO PI10SPHAMIDE Concept Codes: GENETICS/CYTOGNET-ANIMAL(*03506); BIOCHEM STUD-GENERAL( 100G0): PHARMACOL-GENERAL STUD IES(22002): TOXICOL-GENL/EXP STUDS.METHS(*22501): TOXI COL-ENVIRONMNTL.IND- USTR(22506): NEOPLSMS/NEOPL AGNTS-CARCINOGENS(* 24007); NEOPLSMS/NEOPL AGNTS-THERAP.AGNT(24008); CHEMOTHERAPY-GEN STUD.METH.METAB(38502) Blosystemat 1c Codes: MUR I DAE(86375) 16021438 COMPARATIVE MAMMALIAN METABOLISM OF VINYL CHLORIDE AND VINYLIDENE CHLORIDE IN RELATION TO ONCOGENIC POTENTIAL HATHWAY D E ENVIRON HEALTH PERSPECT (21). 1977 (RECD 1978) 53-59 Coden: EVHPA Descriptors: MOUSE RAT CARCINOGEN DNA BINDING Concept Codes: BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-NUCL ACD,PURNS.PYRM( 10062): PHYSIOLOGY-COMPARAT IVE( 1200- 3); METABOLISM-GENL STUD.METAB PATHW(13002): METABOLISM-NUCL ACD,PURINS.PYRIM(13014); TOXI COL-GENL/EXP STUDS.METHS< *22501) ; NEOPLSMS/NEOPL AGNTS-BIOCHEM(* 24006); NEOPLSMS/NEOPL AGNTS-CARCINOGENS{*24007) Blosystemattc Codes: MAMMAL IA-UNSPEC1F1 ED AND EXTINCT(B5700) ; MURIDAE(86375) 16021431 RECENT FINDINGS ON THE CARCINOGENICITY OF CHLORINATED OLEFINS MALTONI C ENVIRON HEALTH PERSPECT Codon: EVHPA (21). 1977 (RECD 1978) 1-5 Descriptors: RAT MOUSE HAMSTER VINYL CHLORIDE VINYLIOENE CHLORIDE STYRENE ACRYLO NITRILE 01 CHLORO ETHANE CHLORO FLUORO CARBONS TRI CHLORO ETHYLENE CARBON TETRA CHLORIDE VINYLIDENE FLUORIDE CARCINOGENS SKIN MAMMARY LEUKEMIA FORE STOMACH TUMORS LYMPHOMA Concept codes: BIOCHEM STUD-GENERAL(10060); DIGESTIVE SYST-PATHOLOGY(* 14006); BLOOD/BODY FLOS'BLO.LYM.RES PATH(*150- 06): BLOOD/BOOY FLOS-LYMPHAT TISS.RES(* 15008); REPRODUCT SYST-PAT1I0L0GY( 16506); INTEGUMENT SYST-PATHOLOGY(* 18506); TOXICOL-GENL/EXP STUDS.METHS(22501); TOXICOL-ENVIRONMNTL,IND- U5TR(22506); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(*24007 ); NEOPLSMS/NEOPL AGNTS-BLOOD.RES(*24010): ENVIRON HEALTH-OCCUPA- TNL HEALTHf37013) Blosystemat1c Codes: CRICETIDAE(86310): MURIDAE(86375) 16021434 INHALATION CHLORIDE TOXICITY LEE C-C; BHANDARI U C; OF VINYL CHLORIDE AND VINYLIDENE WINSTON J M; HOUSE W B; PETERS P J: DI ALO <a e5: BIOSIS Prev R&S 138523 !M2402(See FI 1 16021430 PROCEEDINGS OF THE CONFERENCE ON COMPARATIVE METABOLISM AND TOXICITY OF VINYL CHLORIDE RELATED COMPOUNDS MAY 2-4 1977 FALK H L ENVIRON HEALTH PERSPECT (21). 1977 (RECD 1978) 1-320 Coden: EVHPA Descriptors: SYMPOSIUM Concept Codes: GENL BIOL-SYMPOSIA,PROCONGS.RE VW(*00520); COMPARATIVE BIOCHEM-GENL STUD IES( 10010): BIOCHEM STUO-GENERAL- (10060): METABOLISM-GENL STUD.METAB PATHW(13002); TOXICOL-GENL/EXP STUDS.METH5(*22501); TOXI COL-ENVIRONMNTL.I NO - USTR(22506); NEOPLSMS/NEOPL AGNTS-CAWCINOGENS(24007) 16020671 POLY VINYL CHLORIDE PARTICLE IMPLANTATION IN MOUSE LIVER A TECHNIQUE FOR EXPERIMENTAL STUDY OF SCHISTOSOME EGG INDUCED LIVER PATHOLOGY UOKY A; CORNU M; LOUIS D: GRIMAUD J A EXPERIENTIA (BASEL) 34 (4). 1970 547-548 Coden: EXPEA Descriptors: SCHISTOSOMA-MANSONI PORTAL GRANULOMA Concept Codes: BIOCHEM STUD-GENERAL(10060): ANATOMY/HISTOL-- REGEN.TRANSPLANT 1 1 107 ) : PATHOLOGY-1NFLAMMATN. INFLAM DISH250- 8): DIGESTIVE SYST-GENL STUDS.METHS(14001); DIGESTIVE 5YST- PATHOLOGY(* 14006); CARDIOVASC SYST-GENL STUDS.METHS(1450- 1): IMMUNQL/IMMUNOCHEM-IMMUNOPATHOL(*34508): IMMUNOLOGY-PARAS ITOLOGICAL (35000); PARASITOLOGY-GENERAL(*60502); INVER)B PHYSI0L-PLATYHELMINTHES(64010) BlosystematIc Codas: TREMATODA(45200): MURIDAE(86375) 16019835 ELECTRO tNCEPHALOGRAPH CHANGES IN WORKERS ENGAGED IN VINYL CHLORIDE PRODUCTION DI NCI IE VA E: GAVRILENKO T ELECTROENCEPHALOGR CLIN NEUROPHYSIOL Coden: ECNEA 44 (2). 1978 260 Descriptors: ABSTRACT HUMAN FATIGUE HEAD ACHE SLEEP DISORDERS VINYL CHLORIDE DISEASE Concept Codes: 8EHAVI OR BIOL-HUMAN BEHAVI OR(07004): BIOCHEM STUD-GENERAL( * 10060) : BIOPHYS-GENERAL BIOPHYS TEC,H( 10504); CHORDATE BODY REGNS-HEAD(11304): PATHOLOGY-DIAGNOSTIC(12504); NERVOUS SYST-PHYSIOL . BI OCHEM ( 20504 ) ; NERVOUS S Y ST - P A THOLOC.Y ( *- 20506); PSYCH I ATRY- PSYCHPATH-DYNM.THERAP(21002); PSYCH IATRY-P- $YCHOPHYSIOLOGY(*21003); ENVIRON HEALTH-OCCUPATNL HEALTH(*370- 13) Blosystemat1c Codes: HOMINIDAE(862 15) (C. BIOSIS 1982) (Item 558 of 858) User 3614 25j' 2 109 Concept Codes: BEHAVIOR BIOL-HUMAN BEHAVIOR(07004); BIOCHEM STUO-GENERAL(10060); BIOPHYS-GENERAL BIOPHYS TECH!10504): PHYSIOLOGY-STRESS(12008); MOVEMENT(1210O); PATHOLOGY-GENERAL STUDIES( 12 502); PATHOLOGY -DIAGNOSTIC( 12504): PATHOLOGY - THE RAP- Y( 12512); CARDIOVASC SYST-BLO VESS PATHOL( 14508): URIN SYST/EXT SECR-GEN STUD.METH(15501); URIN SYST/EXT SECR- PATHOLOGY(*1S506): BONE.JNTS.FASC.CONN/AO IP-GENL( 18001 ) ; BONE.JNTS.FASC.CONN/ADIP-PATHOL(* 18006): INTEGUMENT SYST-GENL STUDS.METHS( 18501 ): INTEGUMENT SYST-PATHOLOGY(*18506); NERVOUS SYST-PHYSIOL.BIOCHEM(20504); PSYCHIATRY-PSYCHOPHYSIOLOGY(*21003); TOXI COL-ENVIRONMNTL,INOUSTR(*22506): IMMUNQL/IMMUNOCHEM-IMMUNOPATHOL( *34 508); ENVIRON HEALTH-A IR.W- ATR.SL POLLN(37015) 8losystemat1c Codes: HOMINIDAE(86215) 16017205 LEVELS OF CARCINO EMBRYONIC ANTIGEN AMONG VINYL CHLORIDE AND POLY VINYL CHLORIDE EXPOSED WORKERS ANDERSON 11 A; SNYDER J; LEWINSON T: WOO C: LILIS R; SELIKOFF IJ CANCER (PHILA) 42 (3 SUPPL). 1978 1560-1567 Coden: CANCA Descriptors: HUMAN CARCINOGENS DIAGNOSTIC TESTING LIVER HEM ANGIO SARCOMA Concept Codes: SOCIAL BIOL/HUMAN ECOLOGY(05500): CLIN BIOCHEM-GENL STUD IES(*10006): BIOCHEM METH-PROTNS.PEPTDS . AM AC(10054); BIOCHEM METH-CARBOHYDRATES(1005B); BIOCHEM STUD-GENERAU10060): BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACD{ 10064); BIOCHEM STUD-CARBOHYDR.( 10068); PATHOLOGY-01AGNOS- TIC( 12 504); METAB0L1SM-CARBOHYDRATES( 13004); METABOLISM-PROT- NS,PEPTDS.AM ACDS( 13012); DIGESTIVE SYST-GENL STUDS.METHS( 140- 01): OIGESTIVE SYST-PATHOLOGY(* 14006); CARDIOVASC SYST-GENL STUDS,METHS( 14501); CAROIOVASC SYST-BLD VESS PATIIOL( 14500); BONE.JNTS.FASC.CONN/AD IP-GENL( 18001): BONE.JNTS,FASC.CONN/AD 1P-PATHOL( 18006); TOXICOL -ENVIRONMNTL.INOUSTft(*22506): NEOPLSMS/NEOPL AGNTS-DI A - GNS METH(*24001); NEOPLSMS/NEOPL AGNTS-IMMUNOLOGY(*24003): NEOPLSMS/NEOPL AGNTS-BIOCHEM(*24006): NEOPLSMS/NEOPL AGNTS-CA- RCINOGENSf*24007); DEVELOPMNTL BIOL-GENL,DESCR IPTIVE(* 25502 ) : ENVIRON HEAL TII-OCCUPATNL HE ALTH( * 370 1 3 ) B losystemat1c Codes: HOMINIDAE(862 1 5) 16019679 SCLERODERMA PATHOGENIC FACTORS AND CURRENT MANAGEMENT PENNY R AUST N Z J MED 8 (SUPPL 1). 1978 143-148 Coden: ANZJB Descriptors: HUMAN NEPHROPATHY VASCULAR DISEASE EMOTIONAL STRESS POLY VINYL CHLORIDE TOXICITY DIALYSIS DIALOG FlleS: BIOSIS Previews 77-83/Jon Bj r&S 138524 ) (c. BIOSIS 1982) (Item 563 of 858) User 3614 25Jar>83 2 170 16014 183 DECISION MAKING IN THE REGULATION OF CHEMICALS BROOKS E M JOLLEY, ROBERT L. (ED,). WATER CHLORINATION. ENVIRONMENTAL IMPACT AND HEALTH EFFECTS. VOL. 1. PROCEEDINGS OF THE CONFERENCE ON THE ENVIRONMENTAL IMPACT OF WATER CHLORINATION. OAK RIDGE. TENN. USA, OCT, 22-24. 1075. XVI+439P. ILLUS. ANN ARBOR SCIENCE PUBLISHERS. INC.: ANN ARBOR. MICH., USA. ISBN 0-250-40201-7. 1978 181- 194 Coclen: 06655 Descriptors: HUMAN ASBESTOS VINYL CHLORIDE AFLA TOXIN Concept Codes: GENL BIOL-INSTI TUT.ADMIN.LEGISLN(*00508): BIOCHEM STUD-GENERAL( 10060): MINERALS< 10069); TOXI COL-GENL/EXP STUDS.METHSf*22501): TOXICOL-ENVIRONMNTL.INDUSTR(22506); NEOP- LSMS/NEOPL AGNTS-CARCI NOGENS(24007); MED/CLIN MICROBIOL-MYCOL- OGY(36008); ENVIRON HEALTH-A IR.WATR.SL POLLN(37015): PLANT PHYSIOL-CHEM CONST 1TUENTS(5152 2) Blosystemat1c Codes: DEUTEROMYCETES(15500): HOMINIDAE(86215) 16006569 DETERMINATION OF PLASTICIZER LEVELS IN SERUM OF HEMO DIALYSIS PATIENTS LEWIS L M; FLECHTNER T W: KERKAY J; PEARSON K H: CHEN W T: POPOWNIAK K L: NAKAMOTO S TRANS AM SOC ARTIF INTERN ORGANS (23). 1977 566-571 Coden: TAIOA Dedcr1ptors: BIS-2 ETHYLHEXYL PHTHALATE POLY VINYL CHLORIDE Concept Codes: BIOCHEM STUD-GENERAL ( 10060); BIOPHYS-GENERAL B10PHYS TECH( 10504); BIOPHYS-BIOENGINEERING(* 1051 1); MET ABOLI - SM-GENL STUD.MET AB PATHW(* 13002); BLOOD/BODY FLD5-GENL STUDS.METHS(* 15001); BLOOD/BODY FLDS-BLOOD,LYMPH STUD( 15002): URIN SY5T/EXT SECR-GEN STUD.METl I ( 15501); URIN SYST/EXT SECR-PAT110L0GY( 15506) ; TOX I COL - GENL/EXP STUDS , METI1S ( 2250 1 ) Blosystemat Ic Codes: HOMINIDAE(86215) 16006365 SPONTANEOUS DISLOCATION OF ENDO TRACHEAL TUBES RIPOLL I; LINDHOLM C-E: CARROLL R; GRENVIK A ANESTHESIOLOGY 49 (1), 1978 50-52 Coden: ANESA Descriptors: HUMAN POLY VINYL CHLORIDE TUBE INTERMITTENT POSITIVE PRESSURE VEN1ILATION Concept Codes: RESPIRATORY SYST-GENL STUD.METl IS( 16001); RESPIRATORY SYST-PATHOLOGY( 16006) Blosystemat1c Codes: HOMINIDAE(86215) 16001710 EFTECTS OF CYSTEINE 01 ETHYL MALEATE AND TRI CHLORO PROPANE OXIDE ON ACUTE VINYL CHLORIDE HEPATO TOXICITY CONOLLY R B: JAEGER R J . TOXICOL APPL PHARMACOL 45 (1). 1978 338 Coden: TXAPA Descriptors: ABSTRACT RAT ANTID07ES POLY CHLORINATED BI PHENYL CHLORO ETHYLENE OXIDE GLUI A T111 ONE EPOXIDE HYORASE rnf(ni' rnmP A o a M/ n i (if i ic M * Mi t i fn ? r <; f ipn t n > . BIOCHEM STUO-GENERALC 10060) ; aiOCHF.M StUO-PROTEI NS.PPTIOES.A - MINO ACD(10064); BIOPHYS-MOLECUL PROP.MACROMOLEC(10506); ENZYMES-PHYSIOLOGICAL STUD IES(*10808): METABOLISM-GENL STUD.METAB PATHW(13002); DIGESTIVE SYST-PATHOLOGY(*14006); TOXICOL-GENL/EXP STUDS.METHS(*22501 ): TOXI COL-ANT I DOTES.PREVE NT I V(* 22505); TOXI COL -ENVIRONMNTL,INDUSTR(2 2506); ENVIRON HEALTH-OCCUPATNL HEALTH(37013); ENVIRON HEALTH-A IR.WATR.SL POLLN(*37015) BlosystematIc Codes: MUR I DAE(86375) 16001678 THE EFFECT OF DISULFIRAM ON VINYL CHLORIDE INDUCED CARCINOGENESIS IN MICE WINSTON J M; BHANDARI J C; EL-HAWARl A M; SHORT R D JR; LEE CC TOXICOL APPL PHARMACOL 45 (1). 1978 324-325 Coden: TXAPA Descriptors: ABSTRACT ANT INEOPLAST IC-DRUG MIXED FUNCTION OXIDASE ACTIVITY HEPATIC HEM ANGIO SARCOMA BRONCHIOLO ALVEOLAR ADENOMA Concept Codes: CYT0L0GY/CYT0CHEM-ANIMAL(02506); COMPARATIVE BIOCMEM-GENL STUD IES( 10010); BIOCHEM STUD - GENERAL( 10060 ) : BIOCHEM 'STUD-PROTEINS.PEPTIDES,AMINO ACD( 10064); BIOPHYSMULE - CUL PROP.MACROMOLEC(10506): ENZYMES-PHYSIOLOGICAL STUDIES(*10- 800): DIGESTIVE SYST-PATHOLOGY(14006); CARDJOVASC SYST-BLD VESS PATHOL(14508); RESPIRATORY SYST-PATHOLOGY(16006); TOXICOL-GENL/EXP STUDS.METHS(*22501): TOXI COL-ANT I DOTES.PREVE NT I VE (* 22505 ) ; NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(24007): NEOPLSMS/NEOPL AGNTS-THERAP.AGNT(24008); CHEMOTHERAPY-GEN STUD,METH.METAB(*38502) B losystemat1c Codes: MURIDAE(B6375) 16001651 AN ATTEMPT TO CORRELATE THE CALCULATED STABILITY OF A SERIES OF EPOXIDES WITH THE KNOWN GENO TOXIC PROPERTIES OF THEIR ALKENE PRECURSORS MACKRODT W C; JONES R B: SALMON A G; ASHBY J TOXICOL APPL PHARMACOL 45 (1). 1978 314 Codon: TXAPA Descriptors: ABSTRACT VINYL CHLORIDE VI NY LI DENE FLUORIDE TETRA CHLORO ETHYLENE CARCINOGENICITY MUTAGENICITY Concept Codes: GENET ICS/CYTOGENET-ANIMAL(*03506): MATHEMATIC DIOL/STAT 1ST IC ME T11( 04 500 ) : COMPARATIVE B I OCIIEM-C.ENL STUUIES( 10010); BIOCHEM STUD-GENERAL( 10060); BIOPHYS-MOLECUL PROP.MACROMOLEC(10506); BIOPHYS-BIOCYBERNETICS(10015); TOXICO L-GENL/EXP STUDS.METH5(*22501): NEOPLSMS/NEOPL AGNTS-CARC1 NOG - ENS(*24007) Btosystomnltc Codes: VERT CBR AT A-IJNSPEC I F I ED ( 85 1 50 ) DIALOG e5 : BIOSIS Previews.77-83/Jan R&S 138525 ) (c. BIOSIS 1982) (Item 569 of 858) User 3614 25Jan83 2 17 1 16001581 A COMPARISON OF THE ACUTE INHALATION TOXICITY OF HYDROGEN CHLORIDE VS THE THERMAL DECOMPOSITION PRODUCTS OF POLY1 VINYL CHLORIDE BARROW C 5: LUCIA H; ALAR IE Y TOXICOL APPL PHARMACOL 45 (1). 1978 284 Coden: TXAPA Descriptors: ABSTRACT MOUSE SENSORY IRRITATION STRESS INDEX HISTO PATHOLOGY ACUTE LETHALITY Concept Codes: COMPARATIVE BIOCHEM-GENL STUD IES( 10010): BIOCHEM STUD-GENERAL(10060); BIOPHYS-MOLECUL PROP.MACROMOLEC(- 10506); EXTERN EFF-HOT(106 IB); PHYSIOLOGY-STRESS(* 12008); PATHOLOGY-INFLAMMATN,INFLAM DISC 12508): PATHOLOGY-NECROSIS( 12- 5 10); SENSE ORGANS-PATHOLOGY(20006); NERVOUS SYST-PATHOLOGY(- *20506); TOXICOL-GENL/EXP STUDS.METHS(*22501): TOXI COL-ENVIRO- NMNTL.INDUSTR(22506); TEMPERATURE-GENL,METHS(23001); ENVIRON HEALTH-OCCUPATNL HEALTH(37013); ENVIRON HEALTH-A IR,WATR.SL POLLN(*37015) Blosystemat1c Codes: MUR I DAE(86375) 16001447 RESOLUTION OF DOSE RESPONSE TOXICITY DATA FOR CHEMICALS REQUIRING METABOLIC ACTIVATION USING VINYL CHLORIDE AS AN EXAMPLE GEHRING P J; WATANABE P G; PARK C N TOXICOL APPL PHARMACOL 45 (1). 1978 225 Coden: TXAPA Descriptors: ABSTRACT RAT CARCINOGENICITY BIO TRANSFORMATION HEPATIC ANGIO SARCOMA Concept Codes: MATHEMATIC BIOL/STATISTIC METHT04500); COMPARATIVE BIOCHEM-GENL 5TUDIES(10010); BIOCHEM STUD-GENERAL- (10060): BI0PHY5-M0LECUL PROP.MACR0MOLEC(10506): MOVEMENT(121- 00); METABOLISM-GENL STUD,MET AB PATHW(* 13002): DIGESTIVE SYST-PATHOLOGY(* 14006); TOXICOL-GENL/EXP 5TU0S.METHS(*22501 ); NEOPLSMS/NEOPL AGNTS-CARC I NOGENS(*24007) Blosystemat1c Codes: MURIDAE(86375 ) no. N-Acety1 -S-(2-methoxyethy 1)cysto1ne plus N-acety1 -S-v1ny1 - cysteine degrade to give the volatile S-(2-methoxyethy1)(prop- -1 or 2-eny1)su1f1de. Administration of several vinyl chloride metabolites and closely related compounds to rats shows that ch1oroacota1dohydo and S-(carboxymethy1)-cyste1ne. but not ch1oroacetIc acid, lie on a pathway or pathways connecting vinyl chloride with th1odIg1yco111c acid. The fact that chloroacetaldehyde affords both th1od1g1yco11 Ic acid and N-acety1 -S-(2-hydroxyethy1)-cysteIne In the animal and that S-(carboxymethyI)cyste1ne has heon Identified amongst the hydrolytic products from an hepatic extract prepared from vinyl ch1 or 1de-treated animals Is consistent with the formation of chloroacetaldehyde, and with the reaction of ch1oroethy 1ene oxide or chloroacetaldehyde with glutathione in the presence of a glutathione S-epoxIde transferase to give the Identified S-contatnlng metabolites. Descriptors: SALMONELLA-TYPHIMURIUM NEGATIVE MUTAGEN GLUTATHIONE S EPOXIDE TRANSFERASE CHLORO ETHYLENE OXIDE Concept Codes: GENET ICS/CYTOGENET-GENL STUD IES(*03502); BIOCHEM STUO-GENERAL(* 10060): BIOCHEM STUO-PROTEINS.PEPTIOES .- AMINO ACD(10064); ENZYMES-PHYSIOLOGI CAL STUD IES( 10808); METABOLISM-GENL STUD.METAB PATHW(* 13002); DIGESTIVE SYST-PHYSIOL.BIOCHEM(14004); BLOOD/BODY FLDS-OTMER BODY FLDS( 15010); URIN SYST/EXT 5ECR-PHYSL.BIOCHEM( 15504 ) : TOXICOL-GENL/EXP STUDS,METHS(* 22501): BACTERIAL AND VIRAL GENETICS!31500) Blosystematic Codes: EUBACTERIALE5(07200): MURIDAE(86375 ) 66074259 THE CHEMISTRY AND BIOGENESIS OF THE SULTUR CONTAINING METABOLITES OF VINYL CHLORIDE IN RATS GREEN T; HATHWAY D E CENT. TOXICOL. LAB.. IMP. CHEM. IND. LTD.. ALDERLEY PARK. MACCLESFIELD SK10 4TJ. CHESHIRE. ENGL.. UK. CHEM-B10L INTERACT 17 (2). 1977 137-150. Coden: CBINA Language: ENGLISH In order to determine whether vinyl chloride yields chloroetliyisriB oxide In vivo, the blogonesls of the various urinary S-contatntng metabolites In rats was Investigated. N-Acety1 -S-(2 - hydroxysthy1 )cysteI no Is a major vinyl chloride metabolite In rats. but according to the method of protective esterification that is used, either N-'ace t y 1 -S - ( 2-ch 1 oroe tby 1 - (cysteine or N-acety1-S-(2-hydroxyethy1)-cyste Ine may be Isolated from tho body fluids. N-Acoty1 -S-vIny1cysteIne Is a 2nd related metabolite. Tbeso S-conta InI rig vinyl chloride metabolites are not mutagenic In Salmonolla typhlmurlum. Nowtf'Al mu t hf\nn I mo thylalos -S - f ? - Iwrli'ovvpt hi/1 o * - DI ALO le5: BIOSIS Previews 77-83/Jan BA7502. R&S 1385 66074199 POLY VINYL CHLORIDE FILM THERMAL DECOMPOSITION PRODUCTS AS AN OCCUPATIONAL ILLNESS PART 2 CLINICAL STUDIES BROOKS S M; VANDERVORT R OEP. ENVIRON. HEALTH, UNIV. CINCI.. CINCINNATI. OHIO 45267. USA. J OCCUP MED 19 (3). 1977 192- 19G. Language: ENGLISH Coden: JOfcMA Exposure [occupational] to air contaminants emitted Into the meat wrapping environment may produce acute health effects In some Individuals, The effects relate primarily to eye, nose and throat Irritation. Individuals with bronchial asthma and other types of chronic obstructive respiratory disease may develop bronchspasm as the result of exposure to the Irritants emitted. It cannot be determined from these studies whether actual allergic sensitization and resultant bronchial . asthma occurs from exposure to these contaminants. If actual allergic sensitization does occur. It does not appear to bo common. There Is a possibility that changes may occur In the small airways of the lung as -the result of exposure to PVC [polyvinyl chloride] contaminants. The significance of these changes, If real, cannot be determined from the available data. The high reported prevalence of chronic respiratory symptoms In the meat wrappers studied suggests possible long-term effects from exposure to the air contaminants In the meat wrapping environment. The significance of chronic symptoms cannot be determined since In general. pulmonary function test results for Individuals studied were within normal limits. Persons with bronchial asthma and clinically significant chronic obstructive pulmonary disease should avoid exposure to poorly controlled meat wrapping work environments. Efforts shoud be made to reduce contaminant concentrations In the meat wrapping environment. Descriptors: HUMAN MEAT PACKAGING BRONCHIAL ASTHMA CHRONIC OBSTRUCTIVE PULMONARY DISEASE Concept Codes: B10CHEM STUD-GENERAL(100G0): EXTERN EFF-HOT(10618); METABOLISM-GENL STUD,METAB PATIIW(13002); FOOD TECH-MEAT.MEAT BY-PRODUCTS( 135 16); FOOD TECH-PREP.PR0CES5NG.S- TORAGE(* 13532 ) ; RESPIRATORY S Y S T - PHY S IOL . B IOCHE M ( 1 600-1 ) ; RESPIRATORY SYST - PATHOLOGY(*16006); SENSE ORGANS - PATHOLOGY(20- 006); TOXICOL-ENVIRONMNTL.INDUSTR(* 22506); TEMPERATURE-GENL.M- E T MS(23001): IMMUNOL/1MMUNOCHEM-IMMUNOPATHOL(*34 508); ALLERGY- (*35500): ENVIRON HEALTM-OCCUPATNL HEALTH('37013); ENVIRON HEALTH-AIR.WATR.SL P0LLN(37015) 8losystematIc Codes: HOMINIDAE(86215) . BIOSIS 1982) (Item 572 of 858) User 3614 25jan83 2 172 dI - 2-othy11tcxy1 adipate and HC1. 0 I-2-othyIhoxy1 adipate Is not a significant Irritant to the skin or eye. Little Information Is available regarding Inhalation toxicity of this compound. HC1 can be detected by most persons at concentratIons of 1-5 ppm. At slightly higher concentrations (5-10 ppm), It Is Immediately Irritating and disagreeable. Thermal decomposition products of dicyclohexyl phthalate [the/ film label adhesive major constituent] are eye 1ohexano1. cyclohexyt ether. phthallc nnydrIde and cyclohexyl benzoate. The standard sources of criteria used to assess workroom concentrations of air contaminants are: recommended threshold limit values (TLV) and occupational health standards. TLV and federal standards have not been established for the plasticizers (d I - 2-ethy1hexy1 adipate and dicyclohexyl phthalate) and for cyclohexyl ether and cyclohexyl benzoate. Descriptors: HUMAN MEAT PACKAGING WORKROOM PLASTICIZERS 01-2 ETHYLHEXYL ADIPATE DI CYCLO HEXYL PHTHALATE CYCLO HEXYL ETHER CYCLO HEXYL BENZOATE Concept Codes: MATHEMATIC BIOL/STATISTIC METH(04500): BIOCHEM 5TUD-GENERAL(10060); EXTERN EFF-HOT( 106 18); METABOLISM-GENL STUD.METAB PATHW(13002): FOOD TECH-MEAT.MEAT BY-PRODUCTS(13516): FOOD TECH-PREP.PROCESSNG.STORAGE(13532 ) ; RESPIRATORY 5YST-GENL STU0.METHS(16001): INTEGUMENT SYST-PATHOLOGY(18506): SENSE ORGANS-PATHOLOGY(20006); ROUTES OF IMMUNIZ,INFECT.THERAP(22100): TOXI COL - FOOD,RESI OS.ADD IT.PR - ESRV(22502); TOXI COL-ENVIRONMNrL.INDUSTR(2250G); TEMPERATURE- -GENL.MET1IS(23001): PUB HEALTH-ADMINISIR.STATISTICS(37010); ENVIRON HEALTH-OCCUPATNL HEALTH(* 370 13); ENVIRON HEALTH-AIR.W- ATR.SL POLLN(37015) Blosystemat Ic Codes: HOMINIDAE(862 15 ) 66074198 POLY VINYL CHLORIDE FILM THERMAL DECOMPOSITION PRODUCTS AS AN OCCUPATIONAL ILLNESS PART 1 ENVIRONMENTAL EXPOSURES AND TOXICOLOGY . VANULRVORT R; BROOKS S M. OB ASSOC.' INC., SALT LAKE CITY, UTAH. USA. J OCCUP MED 19 (3). 1977 IBB-19 1. Codon: JOCMA Language: ENGLISH It appears that the major emissions from the hot-wire cutting of PVC [polyvinyl chloride] meat wrapping film are DIALOG e5 : BIOSIS Previews 77-83/Jan BA7502 : RRM2/. R&S 66072242 CARDIAC TAMPONADE CAUSED BY METASTASIZING HEM ANGIQ ENDOTHELIAL SARCOMA OF THE LIVER SYED S; JUNG R T DEP. MORB. ANAT. HISTOPATHOL., JOHN BONNETT CLIN. LAB., ADDENBROOKE'S HOSP. CAMBRIDGE CB2 2Q0. ENGL., UK. BR HEART J 40 (6). 1978 697-699. Language: ENGLISH Coden: BHJUA A case of primary hemang1osarcoma of the liver with secondary deposits In the pericardium Is described. The patient presented most unusually with cardiac tamponade. There was no association with vinyl chloride, thorium dioxide or As. Descriptors: HUMAN PERI CARDIAL DEPOSITS Concept Codes: RADIATION BIOL-RADTN,ISOTOP TECI l( 06504 ) ; RADIATION BIOL-RADTN EFF,PROTECT(06506); BIOCHEM STUD-GENERAL- (10060); MINERALS!10069); PATHOLOGY-THERAPY(12512); DIGESTIVE SYST-PATHOLOGY(* 14006); CARDIOVASC SY5T-HEART PATHOLOGY(1450- 6); CARDIOVASC SYST-BLD VESS PATHOL(14508); BLOOD/BODY FLOS-LYMPHAT TISS.RESC* 15008); BONE,JNTS.FASC,CONN/AO IP-PATHO- L( 10006); COELOM MEMBRANES.MESENTERICS.ETC( 18200): PHARMACOL - - GENERAL STUD IES(22002); PHARMACOL-CL INICAL PHARMACOL(22005); TOXICOL-PHARMACOLOGICAL(22504); TOXICOL -ENVIRONMNTL,INDUSTR(22506); NEOPLSMS/NEOPL AGNTS-PATH- ,CLIN1C(*24004); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(24007); ENVIRON HEALTH-OCCUPATNL HEALTH(37013) B losystemat1c Codes: H0MIN1DAE(86215) 66070751 CHROMOSOMAL ANALYSES IN VINYL CHLORIDE EXPOSED WORKERS PURCHASE I F H; RICHAROSON C R; ANDERSON D; PADDLE G M; ADAMS W G F CENT. TOXICOL. LAB., CENT. MED. GROUP MONO DIV,, IMP. CHEM. IND. LTD., ALDERLEY PARK, MACCLESFIELD, CHESHIRE, ENGL.. UK. MLJTAT RES 57 (3). 1978 325-334. Coden: MUREA Language: ENGLISH Chromosonta 1 morphology from cultured peripheral lymphocytes was studied In 81 men; 57 of the men were employed In plants manufacturing vinyl chloride or polyvinylchloride, 19 were on-site controls and 5 were off-site controls. There was a significant Increase In chromosomal abnormalities In the exposed workers when compared with the controls. The greatest statistically significant Increase In total B cells [cells with either a chromatid break or gap or a chromosome gap] and total C cells [cells with larger chromosomal abnormalities] occurred In autoclave operators, with smaller Increases In other Job categories. The Increase In chromosomal aberrations was correlated with the length of exposure and with a history during .the year prior to sampling (1973-1974) of exposure to excursion levels of vinyl chloride. Information on smoking habits was obtained 18 mo. after blood sampling and a positive correlation between these and total C cell ahnormo1 It l os was found. There was no positive correlation with various other parameters (bilirubin, platelets. .gamma.-g1utnmy1transpept I d- ase. alkaline phosphatasB, alanlno transaminase and aspartate transaminase). It was not possible to estimate which of the 3 parameter's (smoking history, length of employment or oxposure 27 SIS 1982) (Item 574 of 858) User 3614 25J 2 173 to excursion levels) was the most Important. Descriptors: SMOKING AUTOCLAVE OPERATOR GAMMA GLUTAMYL TRANS PEPTIDASE ALKALINE PHOSPHATASE ALANINE TRANS AMINASE ASPAR1A1E TRANS AMINASE Concept Codes: CYTOLOGY/CYTOCHEM-HUMAN(*02508); GENE TICS/CY- TOGENET-HUMAN(*03508); BEHAVIOR BIOL-HUMAN BEHAVIOR(07004); BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-PROTEI NS.PEPTIDES.A - MINO ACD( 10064); BIOCHEM STUD-PORPHYRNS.BILE PIGM( 10065): ENZYMES-PHYSIOLOGICAL STUD IES( 10B08); BLOOD/BODY FLD5-BLOOD . L - YMPH STUD( 15002); BLOOD/BODY FLDS-BLOOD CELL STUDS( 15004 ) ; BLOOD/BODY FLDS-LYMPHAT TISS.RES(* 15008); PSYCHIATRY-ADD ICT10 - N(INC SMOKNG)(21004); TOXI COL-GENL/EXP STUDS,METHS(22501 ) ; TOXICOL-ENVIRONMNTL.INDUSTR(*22506); NEOPLSMS/NEOPL AGNTS-CAR- C1 NOGENS(*24007); TISS CULTURE-APPARAT.METHS.MED I A(32500); ENVIRON HEALTH-OCCUPATNL HEALTH(*37013); PLANT PHYSIOL-CHEM CONSTITUENTS(51522) Blosystemat1c Codes: PLANTAE-UNSPECIFIED(11000); HOM1NIDAE( - 86215) 66070749 MUTAGENIC EFFECTS OF VINYL CHLORIDE ON DROSOPHILA-MELANQGAS- TER WITH AND WITHOUT PRE TREATMENT WITH SODIUM PHENO BARBITURATE MAGNUSSON J; RAMEL C ENVIRON. TOXICOL. UNIT. WALLENBERG LAB.. UNIV. STOCKII. . STOCKHOLM, SWED. MUIAT RES 57 (3). 1978 307-312. Coden: MUREA Language: ENGLISH Treatment of D, melanogaster males with 1-207. vinyl chi orIde In air, a compound carcinogenic In workers at vinyl chi or 1de plants, gave an Increased freqtrency of complete an mosa 1 recessive lethals. Pretreatment with phenobarb1turate for 24 caused an Increase In the mutagenic effect of vinyl chloride. The mixed-function oxygenase system 'can be Induced In D. melanogaster In the same way as In mammals. Descriptors: HUMAN MAMMAL OXYGENASE SYSTEM RECESSIVE LETHALITY Concept Codes: GENETIC5/CYTOGENET-HUMAN(*03508);BIOCHEM- CA SE S ( 1 0012); BIOCHEM STUD-GENERAL(1OOGO): BIOCHEM STUD-PROTEIN- S.PEPTIDES,AMINO ACD( 10064); ENZYMES-PHYSIOLOGICAL STUDIES!*1- 080B); PATHOLOGY-NECROSIS! 12510); TOXI COL-PHARMACOLOGICAL( 225 - 04); TOXICOL - ENVI RONMNTL , I NDUSTR ( * 22506 ) ; ENVIRON HE A t. T H - 0CC1J - PATNL HEALTH! *37013); INVERTB PHYSIOL-INSECTA-PATHOL( 6407B) BlosystematIc Codes: DIPTERA(753 1 4 ) ; MAMMAL I A-UNSPECIF I ED AND EXT INCT(85700): HOMINI DAE(B6215) r(j DIALOG Files: BJOSIS Previews 77-83/dan BA7502;RRM2402(See B, 138528 2) (Item 577 of 858) User 3614 25Jan83 2 174 66068029 SAFETY EVALUATION OF MEDICAL PLASTICS GUESS W L SCH. PHARM., UNIV. MISS.. UNIVERSITY. MISS. 38655, USA. CLIN TOXICOL 12 (1). 1978 77-96. Coden: CTOXA Language: ENGLISH At present, there Is no evidence of toxicity from the use of PVC (polyvinyl chloride] plasticized plastics In medical practice. The major components of plasticized PVC were examined over a span of years, and each passing year sees a conf 1 rmat 1-on of the lack of toxicity. ' From time to time, misconceptions of new workers In the field may raise Issues that were examined and found to no longer be Issues, Cotnsldorlng all the factors of cost, convenience and safety. It appears that plasticized PVC containers continue to have a valuable place In medical practice. Descriptors: REVIEW POLY VINYL CHLORIDE Concept Codes: CLIN BIOCHEM-GENL STUD IE5(* 10006); BIOCHEM STUO-GENERAL(10060); TOXICOL-GENL/EXP STUDS . ME TIIS (* 2250 1 ) were significantly Increased In the early period and then started to decline. The activities of SDH and ATPase reached control values at 150 days, while those of the lysosomal enzymes remained significantly higher up to this period. Hlstopathologlcally. the pulmonary response was In the form of acute Inflammatory changes during the early stages of dust burden, followed by the development of granulomatous lesions containing small amounts of stromal elements. Descriptors: ACUTE INFLAMMATORY CHANGES GRANULOMATOUS LESIONS SUCCINIC DEHYDROGENASE ATPASE ACID PHOSPHATASE BETA GLUCURONIDASE RNASE Concept Codes: MICR05C0PY-HISTOL,HI5T0CHEM TECIK01056); BIOCHEM STUD-GENERALC 10060); BIOCHEM STUD-PROTEI NS.PEPTIDES.A- MIND ACD( 10064); ENZYMES-PHYSIOLOGICAL STUD IES(*10808 ) ; ANATOMY/HISTOL-MICRO.ULTRAMICRSC(*11108): PATHOLOGY-INFLAMMATN,INFLAM DIS(12508 ) : RESPIRATORY SYST-GENL STUD,METlISt 16001): RESPIRATORY SYST-PATHOLOGY(*16006); ROUTES OF IMMUNIZ. INFECT,THERAP(22100): TOXI COL-ENVIRONMNTL. I NOUSTR(- *22506); ENVIRON HEALTH-AIR,WATR.SL POLLNf*37015) BIosystemotIc Codes: MURI0AE(8637 5 ) 66068007 FORMATION OF MONO ETHYLHEXYL PHTHALATE FROM DI ETHYLHEXYL PHTHALATE IN HUMAN PLASMA STORED IN POLY VINYL CHLORIDE BAGS AND ITS PRESENCE IN FRACTIONATED PLASMA PROTEINS/ VESSMAN J; RIETZ G AB HAESSLE, FACK, S-431 20 MOLNDAL. SWEO. VOX SANG 35 (1-2). 1978 75-80. Coden: VOSAA Language: ENGLISH Substantial amounts of MEHP were formed, and In 10 bags from 4-56 ,mu.g/ml were found. After 2 wk at room temperature the concentration of MEHP had Increased to values between 27 and 79 .mu.g/ml. MEHP was also disappearing as shown In a recovery experiment. Of the fractionated proteins, albumin contained MEHP In amounts from < 3-290 .mu.g/g. Concept Codes: BIOCHEM STUD-GENERAL(10060): EXTERN EFF-TEMPERATURE(10614): BLOOD/BODY FLDS-GENL STUDS.METIHS(*150- oi): BLOOD/BODY FLOS-BLOOD.LYMPH STUD(*15002); TOXI COL-GENL/E- XP STUDS,METHS(*22501); TEMPERATURE-GENL.METHS(23001) Blosystemat1c Codes: H0MINIDAE(862 15) 66067902 SOME BIOCHEMICAL AND HISTO PATHOLOGICAL CHANGES INDUCED BY POLY VINYL CHLORIDE DUST IN RAT LUNG AGARWAL D K; KAW J L; SRIVASTAVA S P; SETH P K IND. TOXICOL. RES. CENT,, MAHATMA GANDHI MARG, POST BOX 80. LUCKNOW 226001. U.P.. INDIA. ENVIRON RES' 16 (1-3). 1978 333-341. Codun: ENVRA Language: ENGLISH Enzymatic and pathninorpho1ogIC alterations In rat Kings were studied at dlfforont time Intervals up to 180 days after a Single Intratracheal administration of 25 mg of polyvinyl chloride dust. The activities of 2 energy - I 1nkod enzymes, succinic dehydrogenase (SOU) and AtPasn, and 3 lysosomal itI e5 DIALOG BIOSIS Previews. 77-83/Jan BA7502;RF R&S 138529 BIOSIS 1982) (Item 580 of 858) User 3614 25JanB3 2 175 6C067091 portal hypertension in vinyl chloride monomer workers a HEMODYNAMIC STUDY BLEND IS L M; SMITH P M; LAWRIE B W; STEPHENS M R; EVANS W D TORONTO GEN. H05P., UNIV. WING. ROOM 112. 585 UNIVERSITY AVE.. TORONTO. ONT. M5G 1L7. CAN. GASTROENTEROLOGY 75 (2). 1978 206-211. Coden: GASTA Language: ENGLISH Hemodynamic studies were performed In 5 vinyl chloride monomer workers In whom splenomegaly or thrombocytopen1 a was detected during a screening program at a major chemical plant. Three patients had portal hypertension and collateral venous C1rcu1 atIons. with Intrasplonlc pressures between 20 and 29 mm Hg and norma 1 wedged hepatic venous pressures, but tho gradient between the wedged and free hepatic vein pressures was also Increased. Splenic blood flows were Increased In both hypertensive and normotenslve patients. There was no correlation between the splenic blood flow and the portal pressure or the presence of portal fibrosis. The portal hypertension associated with vinyl chloride exposure Is mainly pres Inuoso I da 1 In type. and may be attributed to an abnormality of the portal vein radicles or hepatic slnuosolds. [Possible medico*legal Implications were also considered.] Descriptors: SPLENOMEGALY THROMBOCYTOPENIA MEDICO LEGAL IMPLICATIONS Concept Codes: GENL BIOL-FORENSIC SCIENCE(00531); CYTOLOGY/CYTOCHEM-HUMAN(02508): SOCIAL BIOL/HUMAN EC0L0GY(O55- 00); BIOCHEM STUD-GENERAL(10060): BI0PHY5-M0LECUL PROP.MACR0M0LEC(10506); MOVEMENT(12100): DIGESTIVE SYST-PATHO- L0GY(* 14006); CARD IOVASC ' SYST-BLD VESS PATHOL(*14508); BLOOD/BODY FLDS-BLOOD,LYMPH STUD(15002); BLOOD/BODY FLDS-BLOOD CELL STUDS( 15004); BLOOD/BODY FLD5-BLD.LYM.RES PATH(* 15006); BLOOD/BODY FLDS-LYMPHAT T1SS.RES(15008); BONE.dNTS.FASC.CONN/- ADIP-PATHOL( 1B0O6); TOXI COL -ENVIRONMNTI..INDUSTR(*22506): ENVI RON HEAL1H-0CCUPATNL HEALTH(*37013); ENVIRON HEALTH-A 1R.WATR.- SL POLLN(*37015) Blosystemat1c Codes: HOMINIOAE(86215) toxicity of DEHP 1s very low (> 20 g/kg ns LD50 In rats), and the ester Is rapidly metabolized to products which are excreted In the urine and bile; chronic toxicity from the levels of dosage obtaining Is thus very Improbable. Carcinogenicity has never been demonstrable In animals, while teratoIog1ca1 effects are of a very low order. Serious acute results observed after transfusion of neonates have not been proved to be caused by DEHP. and might be ascrlbable to accompanying foreign substances. Atheroma in chronic dialysis subjects Is still unexplained. but hepatitis probably caused by dIethy Iphtha1 ate from plastic was resolved when apparatus plasticized by DEHP alone was substituted. The benefits of DEHP appear vastly to outweigh any risks. The status of DEHP os environmental contaminant Is noted. Descriptors; EQUIPMENT RAT HUMAN ENVIRONMENTAL CONTAMINANT MEDICAL Concept Codes: CLIN BIOCHEM-GENL STUD!ES(* 10006): BIOCHEM STUD-GENERAL( 10060); BIOCHEM STUD-LIPIDS( 10066); BIOPHYS-GENE- RAL GIOPHYS TECH(10504); MOVEMENT(12100); METABOLISM-GENL STUD,METAB PATIIW(* 13002); DIGESTIVE SYST-PHYSIOL,B1OCHEM( 1400- 4); DIGESTIVE SYST-PATHOLOGY(14006); CARDJOVASC SYST-BLD VESS PATHOL( 14508); BLOOD/BODY F LDS-GENL STUDS.METHS(*15001); BLOOD/BODY FLDS-BLOOD.LYMPH STUD(* 15002): URIN SYST/EXT SECR-PHYSL,BIOCHEM( 15504); TOXICOL-GENL/EXP STUDS,ME THS(*2250- 1); TOXICOL -ENVIRONMNTL,INDUSTR( 22506); NEOPLSMS/NEOPL AGNT S-CARCINOGFNS(24007); DEVELOPMNTL BIOL-DESCRIP TERATOL(25 - 552); ENVIRON HEALTil-AIR.WATR.SL POLLN(* 370 15) Blosystemat 1c Codes: HOMINIOAE(86215); MUR I DAE(86375) 606 17 18 DI ETHYLHEXYL PHTHALATE AS A FACTOR IN BLOOD TRANSFUSION AND HEMO DIALYSIS BAKER R-W R DEP. CHEM. PATHOL.. GUY'S HOSP. MED. SCH., LONDON S.E. 19RT. ENGL.. UK. TOXICOLOGY 9 (4), 1978 319-330. Coden: TXCYA Language: ENGLISH D1 - 2-ethyIhexy1 phthalate (DEHP), the most frequently occurring plasticizer In medical equipment manufactured from polymers of vinyl chloride, forms about 40% wt/wt of tubes and containers used for storing blood and for hemodialysis. Tho plasticizer leaches out Into liquids with lipid contents, although It Is very sparingly soluble In purely aqueous Solutions. On Infusion of 2-3 1 of stored blood. up to 200 mg DEHP may be transferred to the patient. while much higher quantities may be given during dialysis, which Is moreover nf ton f rni ion t 1 \f lorift r**i *> < *"*r**? THr /'i > M DIALOG^^le5: BIOSIS Previews 77-83/Jan BA7502;RRM24Q2 R& G6061675 COMPARISON OF THE FATE OF VINYL CHLORIDE FOLLOWING SINGLE AND REPEATED EXPOSURE IN RATS WATANABE P G; 2EMPEL J A; GEHRING P J TOXICOL. RES. LAB., HEALTH ENVIRON. RES., DOW CHEM. USA, MIDLAND, MICH. 48640. USA. TOXICOL APPL PHARMACOL TXAPA 44 (2). 1978 391-400. Coden: Language: ENGLISH Rats were exposed by Inhalation to 5000 ppm of nonlabeled vinyl chloride (VC) 6 h/day, 5 days/wk for 7 wk. On the last day of repeated exposure 14C-1abeled VC was used. The fate of the [14C]VC was compared In a group of rats exposed repeatedly to a group exposed simultaneously for a single 6 h period to 5000 ppm of [14C]VC. The routes and rates of excretion of 14C activity were the same for the 2 experimental groups. The activity of microsomal enzymes, as reflected by aniline hydroxylase and p-n1troan 1 so 1e 0-demethy1ase derived from 9000 g liver supernatants, was essentially the same In rats exposed once or repeatedly or In nonexposed control rats. Covalent binding to hepatic macromolecules was greater In rats repeatedly exposed as compared to those subjected to a single exposure. Repeated exposure to VC does not Induce Its bIotransforma11 on. The Increase In hepatic macromolecular binding Indicates that repeated exposure augments the reaction of electrophilic metabolites with macromolecules, and this may be expected to care 1 nogen 1c1ty. enhance potential toxicity Including Descriptors: LIVER CARCINOGENICITY MICROSOMAL ENZYMES Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(*02506); RADIATION BIOL-RADTN.ISOTOP TECH(06504); BIOCHEM STUO-GENERAL(10060); B10CHEM STUD-PROTEINS,PEPTIDES.AMINO ACD(10064); BIOPHYS-GENE- RAL BIOPHYS TECH(10504); BIOPHYS-MEMBRANE PHENOMENA(10508); ENZYMES-PHYSIOLOGICAL STUDIES(* 10808); MOVEMENT( 1210O); METABOLISM-GENL STUD.MET AB PATHW(* 13002); DIGESTIVE SYST-PHYSIOL,BIOCHEM(* 14004); RESPIRATORY SYST-GENL STUD.METH- S(16001); ROUTES OF IMMUNIZ.INFECT.THERAP(22100); T0X1C0L-GEN- L/EXP STUDS,METHS(*22501); NEOPLSMS/NEOPL AGNIS-CARCI NOGENS(24007) 0IosystematIc Codes: MUR I DAE(8637 5) 66061583 HYGIENIC SAFETY PROBLEMS IN THE DOMESTIC USE OF FLUORINE HYDRO CARBON PROPELLANTS IN AEROSOL CONTAINERS BULGAKOV V V; SLOBODSKOI D S A.N. MARZEEV KIEV RES. INST. GEN. PUBLIC HYG., KIEV, USSR. GIG SANIT (4). 1977 22-25. Coden: GISAA Language: RUSSIAN To determine the possibility of using fluorine hydrocarbons as propellents In aerosol packing, use of certain freons and their mixtures Is suggested, as well as of mixtures of freons with dimethyl ether, methylene Is suggested, vinyl chloride, propane, otc. Hygienic Investigations should be carried out with due regard for tho presumed field of use of aerosol packing and should Include detei'mInat1 on of parameters of acute toxicity of samples, the threshold value of their acute 8530 ; 1982) (Item 582 of 858) User 3614 25Jan83 2176 and chronic action on tho body and their action on the skin and the mucous membranes of the eyes of animals and man, [Guinea pigs wore used.) Descriptors: GUINEA-PIG ANIMALS HUMAN EYE SKIN MUCOUS MEMBRANES FREON DI METHYL ETHER METHYLENE CHLORIDE VINYL CHLORIDE PROPANE ACUTE TOXICITY CHRONIC TOXICITY Concept Codes: SOCIAL BIOL/HUMAN ECOLOGY(05500); COMPARATIVE BIOCHEM-GENL STUD IES( lOO10); BIOCHEM STUD - GENERAL( 10060 ) ; METABOLISM-GENL STUD.MET AB PATHW( 13002); INTEGUMENT SYST-PATH0L0GY(18506); SENSE ORGANS-PATHOLOGY(20006); TOXICOL- -ENVIRONMNTL.INDUSTR(*22506); ENVIRON HEALTH-A IR.WATR,5L P0LLN(*37015) BtosystematIc Codes: VERTEBRATA-UNSPECIF1 ED(85150); H0MIN1D- AE(862 15) ; CAVIIDAE(86300) 66059639 ENVIRONMENTAL CARCINOGENS MECHANISMS OF ACTION AND OCCURRENCE SOME ASPECTS PREUSSMANN R DTSCH. KRESBSFORSCHUNGSZENT.. INST. TOXIKOL. CHEMOTHER.. IM NEUENI IE IMER FELD 280, 0-6900 HEIDELBERG 1. W. GER. ZENTRALBL BAKTERIOL PARASITENKD INFEKTIONSKR HYG ERSTE ABT ORIG REIHE B HYG BETRIEBSHYG PRAEV MED 166- (2*3). 1978 144-158. Codon: ZHPMA Language: GERMAN New aspects on the mechanism of action of known environmental carcinogens are described. These compounds are not active as such. but are bioactivated in mammalian metabolism via chemically reactive intermediates to electrophilic reactants, forming with Information-bearing blopolymer covalent bonds. This change in the genetic code Is In agreement with the mutation hypothesis of carcinogenesis, Aflatoxln B1, N-nltroso compounds and benzo(aJpyrene are taken as examples. Threshold levels, e.g., no-effect levels derived from animals experiments with all their Inherent limitations, are compared with data from human exposure to benzo(a)pyron. aflatoxln. N-nltroso compounds and vinyl chloride. The difficulties of such risk evaluations are discussed. Descriptors: HUMAN ANIMAL MAMMALIAN METABOLISM AFLA TOXIN B- 1 N NITROSO COMPOUNDS BENZO A PYRENE VINYL CHLORIDE MUTATION Concept Codes: GENETICS/CYTOGENET-ANIMAL(*03506); GENET ICS/ - CYTOGENE T-I IUMAN(*03508); SOCIAL BIOL/HUMAN ECOLOGY(05500); BIOCHEM STUD-GENERAL(10060); BIOPHYS-MOLECUL PROP,MACROMOLEC(- 10506); METABOLISM-GENL STUD.ME TAB PATHW(13002); TOXlCOL-ENV- IRONMNTL.INDUSTR(*22506); NEOPLSMS/NEOPL AGNTS-BIOCMEM(24006) ; NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007); MED/CLIN MICROBIOL-VIROLOGY(*36006); ENVIRON HEALTH-OCCUPATNL HEALTH!*- 37013); PLANT PHYSIOL-CHEM CONST ITUENTS(51522) 0 Iosys tenia t In Cades: OEUTEROMYCETES( 15500); MAMMAL I A-UNSPEC- IFIEO AND EXT1NCT(85700): HOMIN1DAE(862 15) dialog Flle5: BJOSIS Previews. 77-83/Jan BA7502;RRM2402(See File. R&S 138531 tern 585 of 858) User 3614 25Jan83 2177 66055693 HEADSPACE SAMPLING AND . GAS SOLID CHROMATOGRAPHIC DETERMINATION AND CONFIRMATION OF GREATER THAN 1 PART*PER-BILLION VINYL CHLORIDE RESIDUES IN POLY VINYL CHLORIDE FOOD PACKAGING DENNISON J L; BREDER C V; MCNEAL T: SNYDER R C; ROACH d A: SPHON d A DIV. CHEM. PHYS.. FOOD DRUG ADM., WASHINGTON. D.C. 20204. USA . d ASSOC OFF ANAL CHEM 61 (4). 1978 813-019. Coden: dANCA Language: ENGLISH The determination and confirmation of residual vinyl chloride (VC) In polyvinyl chloride (PVC) food packaging materials are described. PVC packaging materials are dissolved In d1 me thy 1 acetam Ide (DMAC). VC Is sparged from solution with He and collected In sealed vials of ethanol. VC Is detected and quantitated by using a headspace sampling technique and standard gas-solid chromatography (GSC) with flame Ionization detection. GSC peak heights of about 5% full scale deflection are obtained for samples of PVC containing 1 ppb VC. Polymer samples taken from tubing, blood bags, food packaging films, bottles and unprocessed resin were analyzed. Residual VC levels ranges from 0.3-913 ppb. VC was confirmed by GSC-mass spectrometry, using selected Ion recording of m/z 62 and 64 In conjunction with full mass scans to Identify components e1utIng near VC. Descriptors: FLAME IONIZATION DETECTION MASS SPECTROMETRY Concept Codes: BIOCHEM-GASES( 10012); BIOCHEM METH-GENERAL(*- 10050): BIOCHEM STUD-GENERAL(10060); BIOPHYS-GENERAL BIOPHYS TECH(* 10504); MOVEMENT( 12lOO); FOOD TECH-GENL STUDS.METHS(13 - 502): FOOD. TECH-PREP.PROCESSNG.STORAGEf* 13532 ); BLOOD/BODY FLDS-GENL STUDS,METHS( 15001); TOXI COL-GENL/EXP STUDS.METHS(22 - 501): T0X1C0L-F00D,RESIDS.ADDIT.PRESRV(*22502) 10060): BIOPHYS-GENERAL BIOPHYS TECH( 10504); MOVEMENT( 1210O): METABOLISM-GENL S7UD.METAB PATHW(13002): TOXICOL-ENVIRONMNTL- . INOUSTRt*22506): ENVIRON HEALTH-OCCUPATNL HE ALTH(37013): ENVIRON HEALTH-AIR.WATR.SL POLLN(*37015) BlosystematIc Codes: HOMINIDAE(862 15) 66053337 f. ANGIO SARCOMA OF THE LIVER IN VINYL CHLORIDE POLY VINYL CHLORIDE WORKERS 1977 UPDATE OF THE NATIONAL INSTITUTE OF OCCUPATIONAL HEALTH AND SAFETY REGISTER SPIRTAS R; KAMINSKI R ILLNESS EFFECTS SECT., SURVEILL.. BRANCH/SSHEFS/NATL. INST. OCCUP, SAF. HEALTH. ROBERT A. TAFT LAB.. 4676 COLUMBIA PKWY.. CINCINNATI. OHIO 45226. USA. J OCCUP MED 20 (6). 1978 427-429. Coden: JOCMA Language: ENGLISH In Dec.. 1974 NIOSH (National Institute of Occupational Health and Safety] presented data on 26 cases of liver angiosarcoma among vinyl chloride workers. 21 of whom worked In the polymerization process. The present update provides details on 64 cases of angiosarcoma among vinyl chloride polymerization workers reported as of Oct., 1977. Continued surveillance of these workers Is encouraged for; the purpose of furthering knowledge of, this disease process In relation to vinyl chloride exposure. Descriptors: HUMAN USA CARCINOGENS Concept Codes: SOCIAL BIOL/HUMAN ECOLOGY(05500): BIOCHEM METH-GENERAL(10050): BIOCHEM STUD-GENERAL(10060); DIGESTIVE SYST-PATHOLOGY(* 14006); CARDIOVASC SYSt-BLO VESS PATHOL(* 1450- 8): BONE,JNTS.FASC.CONN/AD IP-PATHOL( 18006); TOXI COL -ENVIRONMN- TL.INDUSTRt*22506); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(*24007); PIJB HE ALTH-AOMINI STR . SI AT I ST IC5( 370 10) : ENVIRON HE AL 11I - OCCUP A- TNL HEALTIK *37013) BlosystematIc Codes: MOM 1NIDAE(86215) 66055671 DETERMINATION OF THIO DI GLYCOLIC-ACID IN URINE SPECIMENS OF VINYL CHLORIDE EXPOSED WORKERS MUELLER G; NORPOTH K; KUSTERS E; HERWEG K; VERSIN E INST. STAUBLUNGENFORSCH. ARBEITSMFD, WESTFAEL. WILHELMS-UNIV., D-4400 MUENSTER. W. GER. INT ARCH OCCUP ENVIRON HEALTH 41 (3). 1978 199-206. Codon: I AO! ID Language: ENGLISH A strong correlation was found between vinyl chloride [VC] concentrations at working places and the Increased excretion of th1ooI *j 1yco11c acid of 18 exposed workers. The mean air concentration of VC was calculated referring to personal exposure. The values obtained wore In the range of O. 14-7.0 ppm. The excretion of th1odIg1yco11c oc I d, measured by GC-MS (gas chromatography-mass spectrometry] analysis. amounted to 0.3-4.0 mg/1. Significant Increases in the metabolite excretion may occur even at VC-concerttrat1ons below 5 ppm. Descriptors: HUMAN Concept codes: SOCIAL BIOL/HUMAN ECOLOGY(05500); DIALOG rI 1 e5 : BI OS IS PrevIews 77 *83/Jan 0A75O2 ; RRM2402 ( Sob 66053330 THE HEPATIC ROLE IN CARCINOGENESIS AND ITS EARLY DETECTION THE VINYL CHLORIDE MODEL TAMBURRO C H DIG. DIS. NUTR. OIV., 511 S. FLOYD ST.. PO BOX 35260. LOUISVILLE, KY . -10232, USA. YALE U BIOL MED 51 (1). 1978 67*80. Coden: YJBMA Language: ENGLISH The liver's role In vinyl chloride toxicity and care 1 nogen 1c1ty Is providing a better understand1ng of the chemical carcinogenesis mechanism. A variety of malignant and benign hepatic tumors was demonstrated with prolonged exposure to vinyl chloride. The multisystem Involvement of this carcinogen and toxin provided a model for the study of chemical carcinogenesis common to man and animal. Clinical studies showed the usefulness of biochemical, radioisotopic and radiological studies in the detection of toxic and carcinogenic lesions. Animal studies demonstrated the biochemical metabolism by the 1Iver of vinyl chloride-produced intermediates which are mutagenic In bacterial systems and may be the ultimate carcinogens. Hepatic subcellular enzyme studies prove preliminary evidence of cellular adaptation and increased detoxification. Disruption of this oxidization and detox 1fIcatIon balance may be the key to malignant transformation of cells. A working hypothesis Is presented which may explain the metabolism of vinyl chloride Into mutagenic Intermediates by liver cells and the development of malignant transformat Ion by extrahepatlc sinusoidal lining cells, lung cells and brain tissue. Descriptors: ANIMAL HUMAN BACTERIAL MUTAGENESIS CARCINOGEN LIVER LUNG BRAIN TUMORS METABOLIC CONVERSION SUB CELLULAR ENZYME ACTIVITY ENVIRONMENTAL EXPOSURE Concept Codes: PHOTOGRAPHY-METH5,MATLS.APPARAT(01012); CYTOLOGY/CYTOCHEM-ANIMAL(02506); GENETtCS/CYTOGENET-HUMAN(03508); SOCIAL BIOL/HUMAN ECOL0GY(05- 500); RADIATION BIOL-RADTN,I SOTOP TECH(OG50A); B10CHEM STUO-GENERAU 10060); BIOCHEM STUO-PROTEI NS,PEPTIOES.AM I NO ACD( 1006A ) ; MINERALS! 10069); ENZYME5-PHYSIOLOGI CAL STUDIES(*1- 0808); ANAIOMY/HISTOL-RADIOLOGICC11106); PATIIOLOGY-DIAGNOSTIC- (1250-1); METABOLISM-GENL STUD , ME IAB PATHW( * 13002 ); DIGESTIVE SYST-GENL STUDS.METHS(14001): DIGESTIVE SYST-PHYSIOL.BIOCHEMf- 14004); DIGESTIVE SYST-PATHOLOGY(*14006): RESPIRATORY SYST-GENL STUD,METHS(16001); RESPIRATORY SYST-PATHOLOGY(*1600- 6); NERVOUS SYST-GENL STUDS.METHS(20501); NERVOUS SYST-PATIIOLOGY(*20506); TOXICOL-GENL/EXP STUDS.METHS(22501); rOXI COL -ENVIRONMNTL,INDUSTR( *22506); NEOPLSMS/NEOPL ACNIS-DIA- GNS ME 111(24001); NEOPLSMS/NEOPL AGNT S-B 1 OCI IEM( 24006 ) : NEOPLSMS/NEOPL AGN1S-CARC INOGFNS(* 24007): BACTERIAL AND VIRAL GENLTICS( 1500): MICROBIOLOG APPARAT,ME IMS.MEDI A(32000); ENVIRON HEALTH-AIR,WAT R,SL POLLN(* 37015) Blosystematlo Codes: BACTERI A-UNSPFCIFIED(06000 V; MAMMALIA-- UNSPECIFIED AND EXTINCT(05700): HOMINIUAE(80215) R&S 138532 SB8 of 858) User 361-1 25 3 2 178 KLINF. J; STEIN Z; STROBINO B; SUSSER M; WARGURTON D COLUMBIA UNIV. SCM. PUBLIC HEALTH, 600 W. I68TH ST.. HEW YORK, N.Y. 10032, USA. AM J EPIDEMIOL 106 (5). 1977 345-350. Language: ENGLISH Coden: AJEPA The advantages of using human spontaneous abortions to monitor teratogens In the environment were discussed. A specific cose of parental vinyl chloride exposure provided a possible example. Descriptors: HUMAN VINYL CHLORIDE Concept Codes: BIOCHEM STUD-GENERAL(10060); PATHOLOGY-NECRO- SIS( 12510): REPRODUCT SYST-PATHOLOGY(*16506); T0X1COL-ENVIRON MNTL .INDUSTR(22506); DEVELOPMNTL BIOL-PATHOLOGI CAL(* 25503 ) ; DEVELOPMNTL BIOL-DESCRIP TERATOL( 25552 ) : ENVIRON HEALTH-AIR.- WATR.SL POLLN( 37015) ; EP I DEM I OL-MI SCELL STUOI F.S( 3705G ) B(osystematIc Codes: H0M1NIDAE(86215); BIOSIS INTERNAL USE(97000) I 6604 4 697 SURVEILLANCE OF SPONTANEOUS ABORTIONS POWER IN ENVIRONMENTAL MONITORING DIALOG F11e5: BIOSIS Prev (ews. 77 - 83/Jan BA7502;RWM2402(See F1I r&S 138533 Item 590 of B5B) User 3614 25Jan83 2 179 66037 A 96 A POLY VINYL CHLORIDE BASED ELECTRODE SENSITIVE TO DI BENZYLDIMETHYL AMMONIUM CATION AS A DEVICE FOR MONITORING THE MEMBRANE POTENTIAL IN BIOLOGICAL SYSTEMS SHINBO T; KAMO N; KURIHARA K; KOBATAKE Y NATL. CHEM. LAB. IND., HIRATSUKA, KANAGAWA, JPN. ARCH BIOCHEM BIOPHYS ABB IA 1B7 (2). 1978 414-422. Coden: Language: ENGLISH A polyvinyl chloride (PVC)-based membrane electrode sensitive to dIbenzy1d(me thy I ammonium cation (DDA+) was constructed and operational parameters such as the selectivity coefficients. the detection limit and the response time were obtained. In comparison with the selectivity coefficients obtained with the previous liquid-membrane electrode, significant Improvement was not obtained, but the response time became- pronounced 1y shorter. The electrode lifetime was remarkably prolonged. With the electrode developed, the change In the membrane potential of liposomes containing dlbutyl ferrocene which separated oxidizing and reducing agent solutions was measured. The DDA-t- uptake, U, and the membrane potential estimated from U changed In accordance with the redox potential In the modlum when the concentrat1 on or Internal ferrtcyanlde was kept constant. The membrane potential collapsed when the uncoupler of oxidative phosphorylation was added. The ANS [8-anl1Inonophtha1ene-1-su lfonate] fluorescence measurement Indicated that negative charges appeared on energization with ox I d 1 zIng-reducIng agent. The change In membrane potential of mitochondria [rat liver] during energization' was also measured. The liposome described above Is a good model for the generation of membrane potentials In mitochondria. Descriptors: RAT LIVER MITOCHONDRIA Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(0250G): BIOPHYS-GEN- ERAL BIOPHYS TECH(* 10504 ); BIOPHYS-MEMBRANE PI IENOMENA ( * 10508 ) ; BIOPHYS-BIOENERGETICS(* 10510): BIOPHYS-BIOENG1NEERING(*10511); DIGESTIVE SYST-PHYSIOL,BI0CHEM(14004) BlosystematIc Codes: MUR I DAE(86375) terrain conditions. polymer samples were put near rodent holes. In laboratory conditions, polyethylene samples were most severely gnawed Irrespective of the Included repellent additives (thiourea, altax, dlphenylmethylcarblnol, nicotinic acid, dIphonyIguanId Ine, dIocty1phtha1 ate. calcium stearate and phosphorus containing compounds), and least gnawed were the polyvinylchloride compositions Incorporating such additives as plumbic acetate, BT5-7. BTS-8. lubricant, dIbutyIphtha1 ate, plasticizers, asphalt tar and quartz powder. Partial repellent qualities against 3 spp. of rodents (black rat, ordinary wood mouse and house mouse) showed compositions of polyvinylchloride and of polyamide with addition of finely ground quartz glass. In terrain experiments, polymer were not attacked by rodents and were only slightly scratched. Descriptors: DRYOMYS-NIT EDULA APODEMUS-SYLVATICUS APODEMUS - - FLAVICOLLIS APODEMUS-AGRARI US RATTUS-RATTUS MUS-MUSCULUS M1CR0TUS-ARVALIS CLETHRI0N0MY5-GLAREOLUS POLY ETHYLENE POLY VINYL CHLORIDE DERIVATIVES POLY AMIDE POLYMERS ADDITIVES FOOD BARRIER Concept Codes: BEHAVIOR BIOL-ANIMAL BEHAV1OR(07003); EC0L0C.Y-ANIMAL( *07508 ) ; E COLOGY - T E RRE STR I AL WILDLITE MGMT(*07- 518); BIOCHEM METH-GENERAL(10050); BIOCHEM STUD-GENERAL(10060) ; NUTRITION-GENL,NUT R STATUS.METHS( 13202): PEST CON f RL GENL/PESI ICS/HERB ICS(*54GOO) Blosystemat1c Codes: CRICETIDAE(86310); GLIRI DAE(86355 ): MURIDAE(8G375) 66032927 STUDY ON THE REPELLENT PROPERTIES OF POLYMERS TOWARDS RODENTS KHRISTOV L; MATEVA M INSI. ZOOL., BULG. ACAD. SCI.. SOFIA. BULG. EK0L0G1YA (SOFIA) (2). 1976 (RECO 1970) G1-69. Coden: EKOLO Language; BULGARIAN In the period 1970-1974, repellent properties of 42 modifications of Bulgarian polymers were examined In relation to 9 spp. of rodents: Dryomys nltedula Pall.. Apodemus sylvatlcus L.. A. flavlcollls Melch., A. agrarius Pall. Rattus rattus L.. Mlcrotus arvalls Pall., Clothrlonomys glareolus Schreb., Mus musculus and albino rats of the Wlstar strain. Experiments with rodents were carried out In laboratory conditions In which polymers were put as a barrier to the food of t ho An IruR 1 r or* th* Inttpr f r*rn nprn*ni 4 r* 4 T DIAL' FF 1 1e 5 : BIOSIS Previews 77-83/Jan BA7502;RRM2402(See FfTe55) (c. B R&S 138534 3f 858) User 3614 35Jan83 2100 66032476 CONGENITAL CENTRAL NERVOUS SYSTEM MALFORMATIONS AND VINYL CHLORIDE MONOMER EXPOSURE A COMMUNITY STUDY EDMONDS L D; ANDERSON C E; FLYNT J W JR; JAMES L M BIRTH DEF. BRANCH, CHRONIC DIS. OIV. , BUR'. . EPI DEMI QL . . CENT. DIS. CONTROL. ATLANTA. GA. 30333, USA. TERATOLOGY 17 (2). 1978 137-142. Coden: TJADA Language: ENGLISH Incidence rates for CNS malformations In Infants born to residents of Kanawha County, West Virginia (USA], 1970-1974, were significantly higher than comparable USA rates during those years. Since Kanawha County contains a polyvinyl chloride (PVC) polymerization plant a case-control study was conducted on the possible relationship between the occurrence of CNS defects and parental occupational or residential exposure to vinyl chloride monomer emissions from the plant. No relationship with parental occupation was found. While a tendency was noted for residences of case families to be located In an area northeast of the plant, this observation did not entirely correlate with existing data on local patterns of wind direction and air pollution. Descriptors: KANAWHA COUNTY WE ST - VIRGINI A USA HUMAN Concept Codes: ECOLOGY-BIOCLIMATOL.BIOMETEOROL(*07504): BIOCHEM-GASES( 10012): BIOCHEM STUD-GENERAL( 10060): EXTERN EFF-GENL STUD(10602); NERVOUS SYST-PATHOLOGY(*20506): TOXICOL-ENVIRONMNTL,INOUSTR(22506); DEVELOPMNTL BIOL-DESCRIP TERAT0L(*25552 ) : ENVIRON HEALTH-OCCUPATNL ENVIRON HEALTH-AIR,WATR.SL POLLN(37016) HEALTH(37013): Blosysternat 1c Codes: HOMINIDAE(8G215): BIOSIS INTERNAL USE(97000) 66030667 VINYL CHLORIDE MONOMER RESIDUES IN FOODS AND THEIR PACKAGING ROESLI M; MAREK B EIDG. GE SUNDHEITSAMT LEBENSMITTELKONTROLLE SEKT. PESTI2IDRUECKST AENDE, KONTAMINAT IONEN HASLERSTR. 16. CH-3008 BERN. SWITZ. MITT GEB LEBENSMITTELUNTERS HYG 550-553. Coden: MGLHA 68 (4 ). 1977 (RECD 1978 ) Language: GERMAN Vlnyle chloride monomer (VCM) was determined In market samples of edible oils, salad dressings. vinegars. mineral waters. margarines, and cheeses and In the corresponding PVC - conta Iners, Of 38 analysed food samples, 3 contained more than 0.010 ppm VCM. The monomer residues In the other samples were below 0.005 ppm. VCM was not detected (< 0.1 ppm) in 66% of the PVC-conta1ners. Descriptors: EDIBLE OILS SALAD DRESSINGS VINEGARS MINERAL WATERS MARGARINES CHEESES Concept Codes: COMPARATIVE BI0C1IEM-GENL STUDIES( 100 10); BIOCHEM METH-GENERAL( 10050): BIOCHEM STUD-GENERAL( 100G0); BIOCHEM STUD-LIPIDS(10066); FOOD TECH-GENL STUDS.METHS(13502) ; FOOD TECJ1-MALTS.BREWS.FERMENTATN(* 13512): FOOD TECH-TATS,01- LS(* 13514); FOOD TECH-DAIRY PRODUCTS(* 1 35 1 0 ) ; FOOD TECH-EVALNS PHYS.CHEM PROPsf*13530); FOOD TECM - PREP.PROCES5NG.STORAGE(* 13 - 5 3 2) : TOXICOL -rooo,RES IDS,AUDI T.PMESHV( *22502) 66030666 THE CONTROL OF MONOMER MIGRATION INTO FOODS PACKAGED IN PLASTIC RECEPTACLES POLY VINYL CHLORIDE POLY STYRENE MERAT E: VOGEL J LAB. CANTONAL CHIM.. INST. HYG., 22 OUAI ERNEST-ANSERMET, CH-1211 GENEVE 4. SWITZ. MITT GEB LEBENSMITTELUNTERS HYG 68 (4). 1977 (RECD 1978) 513-522. Coden: MGLHA Language: FRENCH The vinyl chloride and styrene contents of some foodstuffs were measured. The relation between the composition of the foodstuff and the migration of monomers Into It was studied. The Influence of the contact time on that migration was controlled. The determination methods are described. Descriptors: FOOD COMPOSITION INFLUENCE CONTACT TIME DETERMINATION METHOOS Concept Codes: BIOCHEM METH-GENERAL(10050): BIOCHEM STUD-GENERAL(* 10060); MOVEMENT( 12100); FOOD TECH-GENL STUDS.METHS(* 13502); FOOD TECH-EVALNS PHY5.CHEM PROPS(*13530.) ; FOOD TECH-PREP.PROCESSNG,STORAGE!13532); TOXI COL - FOOD.RES IDS- . ADD IT,PRE SRV(*22502) 66025639 METHOD FOR STENOSING VESSELS WITH SUBSEQUENT REMOVAL OF THE STENOSIS LEITES A L: MADAM I NOV S M OIV. NORM. ANAT., KIRG. STATE MED. INST.. FRUNZE. USSR. ARKH ANAT GISTOL EMBRIOL 73 (12). 1977 (RECD 1978) 83-85. Coden: AAGEA Language: RUSSIAN A method for stenoslng major blood vessels In modeling of various pathological states with subsequent easy removal of the stenosis was demonstrated on the rabbit pulmonary trunk. The rubber butt from a pipette Is wrapped around the artery and filled with fluid or emptied by means of a vinyl chloride tube Inserted In the open end of the bulb, allowing varying amounts of pressure to be applied to the vessel. For use In dogs with greater vessel elasticity, the bulb Is attached to a collar made from adhesive plaster. Descriptors: RABBIT DOG Concept Codes: BIOCHEM STUD-GENERAL(10060); BIOPIHYS-GENERAL STUDIES(10502); PATHOLOGY-COMPARATIVE(12503); CARDIOVASC SYST-GENL STUDS.METHS(* 14501); CARDIOVASC SYST-ANATOMY( 14502): CARDIOVASC SYST-BLD VESS PATHOL(*14508) Blosysternatlc Codes: CANIDAE(85765): LEPORI DAE(86040) DIAL File5: BIOSIS Previews, 77-83/Jan BA7502 ; RRM2402 ( See FileS5) (c. BIOSi 858) User 3614 25Jan83 2181 66024967 EFFECTS OF POLY VINYL CHLORIDE PIPE UNDER DRAINAGE ON THE GROWTH OF RICE PLANTS LIM UK; IM H B DEP. AGROBIOL., COLL. AGRIC,, SEOUL NATL. UNIV.. SUWON. S. KOREA. KOREAN J BOT KJBOA 20 (2). 1977 (RECD 197B) 103-108. Coden: Language; KOREAN Two sample varieties of 'Yushln' and 'Jlnheung' were used for the experiment In low-level wotty paddy field which was arranged with PVC pipe underdrainage of 6 m In distance and 60 cm, 90 cm and 120 cm In depth and control, using split plot design with 3 rep 1 Icat1ons. The brown rice yield of 'Yushln' was Increased by 24.8% In the 90 cm plot and 'Jlnheung' by 16.7% In the 120 cm plot, respectively, over the control. The ratio of matured grains of these 2 varieties was Increased significantly by the underdrainage and the number of grains per head of 'Yushln' was also Increased In drained plots. Otherwise, the underdrainage enhanced plant height In the early growth of rice plant and further Increased the culm height and panicle length. The 11ght-rece1vIng efficiency In the later growth of the rice plant might be enhanced, bringing about Increased yields. Descriptors: YIELD HEIGHT PANICLE LENGTH Concept Codes: EXTERN EFF-LIGHT.0ARKNESS(10604); PLANT MORPHOL,EMBRYOL.ANATOMY(510OO); PLANT PIIYSIOL-GROWTH.DIFFRENT- IAT(*51510); PLANT PHYSIOL-LIGHT,RAD IATN EFFS(5 15 16 ) ; AGRONOMY-GRAIN CROPS(52504 ) ; SOIL SC I-FERTILITY.APPLI ED STUDS!*52807) Blosystemat1c Codes: GRAMINEAE(25305) Exposure of mice to 50. 250 or 1000 ppm of vinyl chloride (VC) In the air for 6 h/day. 5 days/wk, caused a high Incidence of bronchioloalveolar adenoma. mammary gland tumors and hemang1osarcoma. Mammary gland tumors occurred In females and Included ductular adenocarc(noma and squamous and anaplastic cell carcinomas with motastases to the lungs. Hemang1osarcoma occurred In the IIver and, to a lesser extent. In various other organs. The Incidence and severity of these tumors Increased with the concentratI on of VC and length of exposure. Malignant lymphoma Involving various organs was Observed In several mice. Rnts wore morn resistant to the care I notion 1c effects of VC. Exposure of rats to 250 or 1000 ppm of VC caused hemangIosarcoma In the 1Iver. Many rats with hepatic hemang1osarcoma also developed hemangIosarcoma In the lung. E x 11. ahepa t t c hemang losarcoma also occasionally occurred In Other organs. Exposure to 55 ppm of vinylIdlnn chloride (VDC) Caused hepatic hemangIosarcoma and probably bronchioloalveolar adenoma In mice. HemarigIosarcoma also occurred In the mesenteric lymph node or subcutaneous tissue In 2 rats exposed to 55 ppm of VDC. THE METABOLISM BY RAINBOW . JT SALMO-GAIRDNERI OF CARBON-14 P P DDT AND SOME OF ITS POSSIBLE DEGRADATION PRODUCTS LABELED WITH CARBON-14 ADDISON R F; WILLIS D E MAR. ECOL. LAB., BEDFORD INST. OCEANOGR., DEP. FISH. ENVIRON.. DARI MOUTH, N.S. B2Y 4A2. CAN. TOXICOL APPL PHARMACOL 43 (2). 1978 303-316. Coden: TXAPA Language: ENGLISH Groups of 5 or 10 rainbow trout fry (S. galrdnerll) weighing around 1 g were Injected l.m. with 14C-labeled p.p'-DDT; p.p'-DDE, p.p'-DDD; 2.2,b1s(p-chloropheny1)-1-chioroethane (p,p'-DDMS); 1. 1-bIs(p-ch1oropheny1)ethy 1ene (p.p'-DONU): 2.2.b1s(p-chloropheny1)-1-chioroethy1ene (p.p'-DDMU); 2,2,-bi- s(p-chIoropheny1)ethano1 (p.p'-DDOH); p-d1ch1orobenzophenone (p.p'-OBP); p-dichlorobenzhydrol !p.p'-DBH); or b I s(p-ch1orop- henyl) acetic acid (p.p'-DDA). At Intervals of 24 h and 3 wk after Injection (except In the case of the p,p'-l14C)DD0H- and P.P'-t 14CJDDA-1njected groups, where only 24 h samples were taken), the fish were killed, extracted Individually and analyzed for p.p'-DDT metabolites. Their water was also analyzed 24 h after Injection. p.p'-[14C )DDT was converted to p.p'-DDE and. to a lesser extent, p,p'-DDD. p.p'-[14CJDDD was converted to a limited extent to p.p'-DDMU, and p,p'-[14C]DDMS was similarly dehydrochi or Inated to p.p'-DDNU. p.p'-[14C]DBH and p.p'-[14CJDBP were Interconverted to some extent, and p.p'-[ 14C )DDA was converted to p.p'-DBP. p.p'-[ 14C)DD0H was apparently converted to p.p'-DBP In 1 experiment. but a 2nd exposure did not confirm this. None of the dehydroch1 or 1natI on products (p,p'-[ 14CJDDE, p.p'-[ 14C]DDMU and p,p'-[ I4CJDDNU) was degraded, and p.p'-DDMU therefore appears to be one of the end products of DDT metabolism by trout. Descriptors: INSECTICIDE Concept Codes: RADIATION BIOL-RADTN,ISOTOP TECH(06504); ECOLOGY-AQUATIC WILDLIFE MGMT(*07516); ECOLOGY -WAT R RESRCH.EISIIERY BI0L(O7517); BIOCHEM STUD-GENERAL(10060); MET ABOL JSM-GENL STUD.METAB PATHW(* 13002); MUSCLE SYST-GENL STUDS.METHS( 17501 ): ROUTES OF IMMUNIZ.INFECT.THERAP(22100); TOXICOL-GENL/EXP STUDS.METHS(*22501); PEST CONTRL GENL/PESTIC- S/IIERBICS(*54600); ECONOM ENTOMOL-CHEM PHYS CONTRL(60016) Blosystemat1c Codes: ENTOMOLOGY(06000i OSTEICHTHYES(85206); ABSTRACTS OF 66018442 DIAL lleS: BIOSIS Previews 77-03/.Ian BA7502;RRM2402(See F e55) (c. BIOSIS 1! R&S 138536 User 361 A 25jan83 2 182 660 I 4480 THE MUTAGENIC EFFECT OF 1 2 DI CHLORO ETHANE ON SALMONELLA-TYPHIMURIUM PART 1 ACTIVATION THROUGH CONJUGATION WITH GLUTATHIONE IN-VITRO RANNUG U: SUNOVALL A; RAMEL C ENVIRON. TOXICOL. UNIT. WALLENBERG LAB., UNIV. STOCKH.. S- 106 91 STOCKHOLM, SWEO. CHEM-BIOL INTERACT 20 (1). 1978 1-16. Coden: CBINA Language: ENGLISH One of the main components In the waste products from vinyl chloride Industries (EDC-tar), Is ethylene dlchlorlde ( 1,2-d1 chioroethane). This compound was tested for mutagenicity on S. typhlmurlum TA 1535. Apparently, 1.2- d1 chioroethane gives a weak direct mutagenic effect, which Is enhanced by addition of [rat] postm1tochondr1 a 1 liver fraction (5-9). This activation Is NADPH-1ndependent and non-m1crosoma1. It Is caused by a factor In the soluble fraction (115.000 g supernatant). This activation was further enhanced by the addition of glutathlono but not by the addition of L-cystelne. N-acety1 -L-cysteIne or 2-mercaptoethanol. No activation was observed when glutathione was added In the presence of a totally denatured 5-9 fraction or In the absence of, this fraction. Activation of 1.2- dlchloroethane was also found In the presence of glutathione and glutathione S-transferase A and C but not with glutathione S-transferase B. A synthetic conjugate S-(2-ch1oroethy1)-L-cyste I ne gave a strong direct mutagenic effect at concentrations where no effects were seen with 1.2-d1 chioroethane. Apparently. 1 .2-dIch1oroethane Is activated by conjugation to glutathione. Another main component in EDC-tar, 1 . 1.2-tr1ch1oroethane, was not mutagenic under any experimental conditions. For comparison 1.2- dIbromoethane was also tested and gave a stronger direct mutagenic effect than 1.2-dIch1 oroothane. Like the latter 1.2 -dIbromoethane was also activated by a NADPH-Independent proccss. Descriptors: RAT LIVER FRACTION 1 2 DI BROMO ETHANE 1 1 2 TRI CHLORO ETHANE MUTAGENS NADPH GLUTATHIONE S TRANSFERASE Concept Codes: CYTOLOGY/CVTOCHEM-ANIMAL(02506); GENETICS/CY- TOGENET-ANIMAL(-03506): BIOCHEM STUD-GENERAL( 10060): BIOCHEM STUD-NUCL ACD.PURNS,PYRM( 10062): BIOCHEM STUD - PROTEI NS.PEPTID- ES.AMINO ACD(10064); BIOPHYS-GENERAL B10PHYS TECH(10504); ENZYMF.S-GEN.COMPAR STUD.COENZYMS( 10802): ENZ YME S - ME THODS ( 1080- 4); MOVEMfjT( 12 100) ; MET ABOL I SM-GENl. STUD ,MET AB P ATI IW( 1 3002 ) ; DIGESTIVE SYST-GENL STUDS.MET IIS( 14001); TOX 1 COL-GENL/EXP S TUDS,METH5(*2 2501); BACTERI A -PHYSlOLOGY.BtOCHEMISTRY(*31000); BACTERIAL AND VIRAL GENETICS(* 31500): MICROBIOLOG APPARAT.METHS.MEDIA(32000) Blosystemat1c Codes: EUBACTERIALES(07200); MUR I DAE(86375) Some aspects u. ..... an acceptable level of exposure are discussed. for If there Is such a thing, threshold limit values [TLV] have scientific meaning. If. on the other hand. there Is no such thing as a no-effect but finite level of exposure. then the TLV must be considered In terms of that which Is socially and politically acceptable, rather than in terms of what Is scientifically correct. Some of the history of the development of [human] Industrial toxicology and Industrial hygiene Is given. The American Conference of Governmental Industrial Hygienists took the lead in publishing and up-dating annually a list of atmospheric exposure levels deemed to be acceptable the TLV list. Today the big topic of discussion about acceptable limits of exposure concerns those "chemical substances which might possibly Induce cancer. Where there has been a sufficiently long period of human exposure to a substance. It may well be worthwhile to do retrospective epidemiologic studies to see whether any peaks of disease have emerged above the noise level. If such peaks have emerged, as they did with asbestos, vinyl chloride, b 1 s-chioromethy 1 ether and a few others, exposure levels were too high. If It Is possible to estimate exposure levels which would keep toxic effects below that point where they emerge from the background and become Identifiable, those levels would represent acceptable levels of exposure for now. Descriptors; HUMAN INDUSTRIAL TOXICOLOGY INDUSTRIAL HYGIENE ATMOSPHERIC EXPOSURE LEVELS THRESHOLD LIMIT VALUE CARCINOGENS ASBESTOS VINYL CHLORIDE BIS CHLOROMETHYL ETHER Concept Codes: SOCIAL BIOL/HUMAN ECOLOGY(05500); BIOCHEM STUD-GENERAL( 10060): MINERALS( 10069); TOXI COL-ENVIRONMNTL.IND- USTR(*22506); NEOPLSMS/NEOPL AGNTS-CARCINOGENS(*24007); PUB IIEALTH-ADMINISTR.STATISTICS(*37010); ENVIRON HEALTH-OCCUPATNL HEALTHf*37013); ENVIRON HEALTH-A IR.WATR.SL P0LLN(37015); EPIDEMIOL-ORGANIC DIS.NEOPLASMS(37054) BlosystematIc Codes: HOMINIDAE(86215) GG0120/3 AN ACCEPTABLE LEVEL OF EXPOSURE ZAPP J A JR 318 MARSHALL ST.. KENNET SOUARE. PA. 19348. AM IND HYG ASSOC J 38 (9). 1977 425-431. Language; ENGL ISH USA. Codon: A1 HAA niAL0(Tnie5: BIOSIS Previews, 77-83/Jan BA7602 ; RRM240? ( See FMe5 ) (c. BIOSIS 1 R&S 138537 ) User 3614 25JanQ3 2 183 66012064 TESTING OF INDUSTRIAL CHEMICALS .MCLEAN A E M LAB. TOXICOL., DEP. CLIN. PHARMACOL.. UNIV. COLL. HOSP. MED. SCH.. LONDON WC1E 6JJ. ENGL., UK. LANCET 2 (8047). 1977 1070-1071. Coden: LANCA Language: ENGLISH Some 500 new chemicals are Introduced Into (United Kingdom] commerco each year. Until now It has been quite usual for the toxicity of a new chemical to remain undiscovered until the workers fell 111 or died, as happened with beryllium. vinyl chloride. asbestos, nltrosamlnes and .beta.-naphthy1 am Ine. This Is clearly Intolerable. The Health and Safety Commission and Its Executive (H.S-E.) have the duty of working towards health and safety at work and have put forward a scheme In which al1 new chemicals . should be tested before use. The scheme Is. so far. limited to new chemicals made or Imported In amounts of 1 ton a year or more, Tho suggested procedures comprise the following: observation of the effects on rats of a single dose In the lethal range (acute toxicity test and LD50): Irritancy to the skin and eye, and sensitization test: effects of 30 days of exposure; mutagenic potential to bacteria and tissue culture cells (as tests of carcinogenicity); effects on the fetus In pregnant rats, effects on 1 fish species and stability In soil or sewage. The scheme seems sensible but there are underlying drawbacks. First, the scheme takes no account of the consumer or environment. How can 1 1 t be decided that a new chemical Is fit for use In Industry. or as a drug. food additive. or pesticide? There are 4 essential steps In the process of decision: toxicity Is measured; hazard Is assessed; risk Is evaluated: and epidemiological follow-up Is done. Descriptors: HUMAN UN ITED-KINGOOM WORKER RAT FISH BACTERIA FETUS TERATOGEN CARCINOGEN IRRITANT SENSITIZER MUTAGEN TERATOGEN ENVIRONMENTAL EFFECTS SOIL POLLUTION SEWAGE Concept Codes: GENETICS/CYTOGENET-GENL STUDIES(03502); ECOLOGY-GENL STUD IES,METH0DS(07502); ECOLOGY-WATR RESRCH.FISH ERY B1OL(07517): BIOCHEM STUD-GENERAL(10060): PATHOLOGY-NECRO- SI5( 12610): REPRODUCT SYST-PHYSIOL.B10CHEM( 16504); INTEGUMENT SY$T-PATIIOLOGY( I050G); SENSE ORGANS - PATHOLOGY(2000G); TOXICOL- -GENL/EXP STUDS.METHS(22501); TOX I COL -ENVIRONMNTL.INDUSTR(*22- 506): NEOPLSMS/NEOPL AGNT5-CARCI NOGENS(24007); DEVELOPMNTL BI0L-EXPERIMENTAL(255O4); DEVELOPMNTL BIOL-DESCRIP TERATOL(25- 552); DEVELOPMNTL BIOL-EXPER TCRATOL(20554); BACJERIAL AND VIRAL GENETIC5(31500): TISS CUETURE-APPARA I.MET IIS,MED I A(32500) ; 1MMUNOL/IMMUNOCI IE M- 1MMUNOPAT 110L(34 008): ALLERGY(35500): PUB HE ALTH-ADM INIsrR.STATISTICS!*37010): ENVIRON HEALTII -OCCUPAINL HEALTIK *37013) : ENVIRON HEALTH-SEWG DISP.SANITAR(370 I 4): ENVIRON HEALTH-AIR,WATR.SL POLLN(* 37015): EPI OEM IOL-MISCELL STUD 1ES(37056 ) ; SOIL SCI-FERTILITY.APPLIED STUbS(026O7) Blosystemat Ic Codes: BACTERI A-UNSPECIFI ED(OCOUO): P1SCES-UN- SPECIFIED(852 00): IIOMINIDAE(86215): MUR I DAE(86375) LI0ESKINO M; LUGAGNE F; MALBRAN J; VILLCMANT J-F; GUYET-ROUSSET P SERV. GASTROENTEROL.. LAB. ANAT.-PATHOL.. F 95500 GONESSE, FR. GASTROENTEROL CLIN BIOL 1 (12). 1977 (RECD 1978) 1027-1034. Coden: GCBIO Language: FRENCH The case of an adult patient with angiosarcoma of the liver and spleen was reported. From this observation and other reported cases (about 150) In the literature. tho clinical features and course of this malignant tumor were delineated. In most cases observed, vinyl chloride Intoxication was responsible for the development of this tumor. In the reported case, this cause was absent." Descriptors: HUMAN Concept Codes: BIOCHEM STUD-GENERAL(10060); DIGESTIVE SYST-PATHOLOGY(* 14006); CARDIOVASC SYST-BLD VESS PATHOL(* 1450- B): BLOOD/BODY FLOS-BLO,LYM.RES PATH(15006); BLOOD/BODY FLOS-LYMPHAT TISS.RES(* 15008); BONE.JNTS.FASC.CONN/AD 1P-PATHO- L(18006); TOXICOL-ENVIRONMNTL,INOUSTR(22506); NEOPLSMS/NEOPL AGNTS-PATH.CLINIC(*24004); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(2 - 4007); NEOPLSMS/NEOPL AGNTS-BLOOD.RES(240 10); ENVIRON HEALTH-OCCUPATNL HEALTH(37013) B losys tenia t I c Codes; IIOMINIDAE (862 15 ) 66008304 A DOMINANT LETHAL STUDY IN MALE RATS AFTER REPEATED EXPOSURES TO VINYL CHLORIDE OR VINYLIDENE CHLORIDE SHORT R 0; MINOR J L; WINSTON J M: LEE C-C PHARMACOL. TOXICOL., MIDWEST RES. INST., 425 VOLKER BLVD.. KANSAS CITY. MO, 64110. USA. J TOXICOL ENVIRON HEALTH 965-968. Coden: JTEHO 3 (5-6). 1977 (RECD 1978) Language: ENGLISH Male CD rats were exposed 6 h/day for 5 days/wk to 0. 50, 250 or 1000 ppm of vinyl chloride or 55 ppm of vinyl Ideno chloride. Starting on wk 11 of exposure. these males were mated with untreated females. There was ho evidence of either pro Imp1antatI on loss or postImp1 antat1 on loss In pregnant females that resulted from these matings. These exposures did not produce germinal mutation, as manifested by a dominant lethal effect. In male rats. Oer.cr tptors ; PRE IMPLANTATION LOSS POST I MPl ANT AT I ON LOSS Concept Codes: GENETIC5/CYTOGENET-AN1MAL(*03506); BIOCHEM SrUD-GENERAL( 10060); REPRODUCT SYST-PHYSIOL.B1OCIIEM(* 16504 ); TOXICOL-GENL/EXP 51UDS.METHS(*22501): DEVELOPMNTL BIOL-PAHIOLOGICA L(*25503) BIosystornatIp Codes: MUR IOAE(86375) 66010059 HEPATO SPLENIC ANGID SARCOMA REPORT OF A CASE AND REVIEW OF THE LITERATURE DIAL R&S 138538I 1e5: BIOSIS Previews 77-83/Jan BA7502;RRM2402(See F 55 (c. BIOSIS 1982) (I 3614 25 J in83 2 184 66006096 ACUTE HEPATO TOXICITY OF ETHYLENE VINYL FLUORIDE VINYL CHLORIDE AND VINYL BROMIDE AFTER AROCLOR 1?54 PRE TREATMENT CONOLLY R B; JAEGER R J; SZABO S DEP. PHYSIOL.. HARV. SCH. PUBLIC HEALTH. BOSTON, MASS. 02 i 1 5 , USA. EXP MOL PATHOL 28 (1). 1978 25-33. Coden: EXMPA Language: ENGLISH Male rats were pretreatod by gnvage witb the polychlorinated biphenyl mixture (PCB) Aroclor 1254 (300 .mu.mo 1 of PCB/kg) for 3 consecutive days. On the 4th day these rats were exposed by Inhalation (4 h) to various concentrations of ethane, ethylene, fluoride monomer (VFM), vinyl chloride monomer (VCM) or vinyl bromide monomer (VBM). Animals were sacrificed 24 h after exposure and acute hepatic responses were estimated by measurement of serum a 1 an 1ne-.a 1pha.-ketoglutarate transamina se (SAKT) and light microscopy. All compounds tested. except ethane. caused significant elevations of SAKT and produced severe degenoratI on and necrosis of the liver. Typical SAKE values (milligrams of pyruvate per milliliter of serum per hour) were: absolute controls. 0,17 .+-. 0.01; PCB pretreated, not exposed. 0.19 .+-. 0.02; PCB and 50,000 ppm of ethane. 0.11 .+-. 0.02; PCB and 25.000 ppm of ethylene. 1.98 .+-. 0.61; PCB and 10.000 ppm of VFM 6.29 0.99; PCB and 10.000 ppm of VCM 1.11 .+-. 0.32; and PCB and 33.000 ppm of VBM, 3.78 -+*. 2.28. The relative potencies of these compounds In elevating SAKT were similar, and the spectrum of morphologic changes (e.g.. mldzonal ballooning of hepatocytes and centro1obu1ar hemorrhagic necrosis) was the same. The acute hepatoxlclty of ethylene plus PCB and lack of effect from ethane plus PCB Indicate a role for the double bond In these toxic Interactions. With the exception of ethane the compounds tested are similar In acute toxicity after PCC pretreatment. This similarity of acute action, In light of the core I nogen IcIty of VCM, suggests that ethylene, VMF and VBM should be evaluated for chronic effects. Descriptors: RAT CARCINOGENICITY LIGHT MICROSCOPY SERUM ALANINE ALPHA KETD GLUTARATE TRANS AMINASE Concept Codes: MICROSCOPY-GENL.SPECL TECI INI DUES(01052); CYTOLOGY/CYTOCMEM-AN1MAL( `02506); COMPARATIVE BIOCI IE M-GENL STUDlESt 10010): BIOCHEM STUD-PROTEI NS.PEPTIDES.AMI No ACD(1006- 4); ENZYMES-PHYSIOLOGICAL STUD IES(*10808); PATHOLOGY-NECROSIS- (12510); DIGESTIVE SYST-GENL STUDS.METIIS( 1 4001); DIGESTIVE SYST-PATH0L0GY( 14006); ROUTES OF IMMUNtZ.I NTCCT,THERAP(22100) ; TOXICOL-GENL/EXP STUDS.METHS(2250 I); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(*2 4007) Blosystematic Codes: MURI0AE(86375) In water and their pediatric Implications were discussed. The EPA [Environmental Protection Agency] prepared a list of 221 organic compounds Identified In drinking water In the USA as of June 1. 1975. Among them are vinyl chloride, pesticides and polycyclic hydrocarbons, compounds which In occupational exposures have been harmful to man. In addition the EPA has reported on excessive Pb In tap-water. In a study by the EPA of 6 organic chemicals of particular concern. It was found that chlorination contributed to the formation of 4: chloroform, bromoform, bromodlch1oromethane and d1 chiorometha- ne. In addition to the effects of Individual compounds, there Is the possibility of Interactions. With regard to the health risk from organics In drinking water. study group of the EPA deemed chloroform to be most suspect as a potential human carcinogen because It Induces liver tumors In mice. There Is no epidemiologic evidence of Its carcinogenicity In man. It was noted. Although certain other contaminants evaluated by the study group were thought to have carcinogenic potential the risk In man. If any, was thought to be minor because of tho low concentrations and Infrequent occurrence of tnese chemicals In drinking water. The fetus and child may be more susceptible than the adult to the effects of chemical pollutants, end long life-expectancy may allow accumulation of sufficient doses and survival through extended latent periods. There Is at present, however, no basis for recommending a change In water supply because or potential carclongens. Descriptors; HUMAN FETUS CHILD MOUSE USA OCCUPATIONAL EXPOSURE ENVIRONMENTAL EXPOSURE VINYL CHLORIDE PESTICIDES POLY CYCLIC HYDRO CARBONS LEAD CHLOROFORM Concept Codes: ECOLOGY-LIMNOLOGY(*07514); ECOLOGY-WATR RESRCH,FISHERY BI0H07517); BIOCHEM STUD-GENERAL (* 10060 ) : MINERALS(10069); PATHOLOGY-COMPARATIVE(12503): DIGESTIVE SYST-PATHOLOGY(14006); TOXICOL*ENVIRONMNTL.INDUSTR(*22506); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(24007); PEDI ATRICS(25000); DEVELOPMNTL BIOL-PATHOLOGICAL(25503); PUB HEALTH-AOMINISTR.ST ATIST ICS( 370 10) ; ENVIRON HE ALTH-OCCUP ATNL HE AI.TH ( 370 13 ) ; ENVIRON HEALTH-AIR.WATR.SL P0LLN(*37015): EPIDEMIOL-ORGANIC DIS.NE0PLASM5(37054); PEST CONTRL GENL/PESTICS/HERBICS(54600) Blosystemat1c Codes: HOMINIDAE(86215); MUR I DAE(86375 ) 66003110 4 CARCINOGENS IN DRINKING WATER AM ACAO PE01ATR COMM ENVIRON HAZARDS AM. ACAD. PHD IA TR, . EVANSTON. ILL. 60204. USA. PEDIATRICS 57 (4 ). 1976 462-464. Coden: Pt'DIA Language: ENGLISH Human exposure to asbestos in the water supply and In occupational Or environmental exposures, chemical carcinogens l^^^5 DIAL'^FFIleS: BIOSIS Previews 77-83/Jan BA7502;RRM2402(See F^55) (c. BIOSIS 1982) (Item R&S 138539 25Jan83 2185 66003850 FORMATION OF 3 N-4 ETHENO CYTIDINE MOIETIES IN RNA BY VINYL CHLORIDE METABOLITES IN-VITRO AND IN-VIVO LAIB R J; BOLT H M INST. TOXIKOL.. UNIV. TUEB,. WILHELMSTR. 56. D-7400 TUEBINGEN, W. GER. ARCH TOXICOL 39 (3). 1978 235-240. Coden: ATXKA Language: ENGLISH Rats were exposed to [1.2-14C] vinyl chloride. Liver RNA was Isolated. hydrolyzed and the nucleosides were separated on Amlnex-A-6. Besides the physiological bases and 1.N6-ethenoadenos1ne, radioactivity was also Incorporated Into 3,N4-ethenocyt1dIne, Radioactive 3.N4-ethenocytId1ne moieties were also formed on Incubation of po1ycyt1dy1 Ic acid with rat liver mlcrosomes. NADPH and [14C] vinyl chloride. These alkylation mechanisms are consistent with the mutagenic and cancerogenlc properties of vinyl chloride. Descriptors: RAT LIVER CARCINOGEN MUTAGENICITY AMINEX A-6 SEPARATION Concept Codes: GENETICS/CYTOGENET-ANIMAL(*03506); RADIATION BIOL-RADTN,ISOTOP TECH(06504); B10CHEM METH-NUCL ACD.PURNS,PY- RM(10052); BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-NUCL ACD.PURNS,PYRM(10062); REPL ICATN,TRANSCRIPTN.TRANSLATN( 10300) ; 8I0PIIYS-M0LECUL PROP,MACR0M0LEC(+10506); METABOLISM-NUCL ACD.PUR I NS,PYRIM(13014); DIGESTIVE SYST-PHYS101..B10CHEM(*140- 04); TOXICOL-GENl/EXP STUDS.METHS(*22501); NEOPLSMS/NEOPl AGNT S-BI0CHEM(*24006); NEOPLSMS/NEOPL AGNTS-CARCI NOGENS(*2400- 7): IN VITRO STUDS-CELLULR.SUBCELLt 3 2600) BlosystematIc Codes: MUR I DAE(86375) TECH-PREP,PROCESSNG,STORAGEf * 13532) ; TOXICOL-FOOD.RESIDS.AOOIT,PRESRV(* 22502 ) ; TEMPERATURE-GENL.METHS(2300 t): HORTI CULT-TROP FRUIT,NUT.PLANT AT(53004) BlosystematIc Codes: OLEACEAE(26475 ) ; RUTACEAE(26685 ) 65074110 ETIOLOGY OF THE THROMBOCYTOPENIA IN VINYL CHLORIDE DISEASE HEUSERMANN U; STUTTE H-J ABT. ALLG. PATHOL. PATHOL. ANAT., INST. PATHOL.. UNIV. KIEL. POSTFACH 4324. 0-2300 KIEL 1. W. GER. BLUT 35 (4). 1977 (RECDI97B) 317-322. Coden: BLUTA Language: GERMAN / Thrombocytopenia Is often 1 ' of the 1st signs of vIny1 chi oride disease. Morphological Investigations showed that (t (s caused by splenic [human) alterations. Besides splenomegaly, there are significant structural changes In the red pulp cords affecting the microcirculation. These quantitative and qualitative alterations cause Increased platelet pooling and Increased destruction of platelets, which rosult In a decrease In thrombocytes In the peripheral blood. Descriptors: HUMAN SPLENIC ALTERNATIONS Concept Codes: MICROSCOPY-HISTOL.HISTOCHEM TECH(01056); BIOCHEM STUD-GENERAL(10060): ANATOMY/HISTOL-MICRO.ULTffAMICRSC- (11108); BLOOD/BODY FLDS-BLOOD.LYMPH STUD(15002); BLOOD/BODY FLDS-BLD.LYM.RES PATH(* 15006); BLOOD/BODY FLDS-LYMPHAT TISS.RES(* 15008); TOXI COL-ENVIRONMNTL.INDUSTR(*22506); ENVIRON HEALTH-AIR.WATR.SL P0LLN(37O15) Blosystcm.it Ic Codes: HOMINIDAE ( 862 1 5 ) 65074128 SOME OBSERVATIONS ON THE DETERMINATION OF MONOMER RESIDUES IN FOODS CHUOY J C; CROSBY N T LAB. GOV. CHEM, . DEP. I NO. . CORNWALL HOUSE. STAMFORD ST.. LONDON SE1 9NQ. ENGL., UK. rOOD COSMET TOXICOL Coden: FCTXA 15 (6). 1977 (RECD 1978) 547-552. Language: ENGLISH The effects of various experimental parameters on the determination by headspace gas chromatography of residues of vinyl chloride and of aery 1 on 1tr1 Ie In foods were examined. Preliminary Investigations on the choice of solvent. the effects of varying duration and temperature of storage and the ratio of headspace to solvent volumo ro reported. Headspace gas chromatography was used to follow the migration of vinyl chloride from PVC [po1yv1ny1ch1 or 1de 1 Into orange drink, wine, olive oil and water. Descriptors: ORANGE DRINK WINE OLIVE OIL WATER POLY VINYL CHLORIDE ACRYLONITRILE CHROMATOGRAPI IY Concept Codas: BIOCHEM METlt-GENCRAL(*10050); BIOCHEM SIUU-GENERAL( 10060); BIOPHYS - GENERAL BIOPHYS TEC1I( 10504); EXTERN EFF-TEMPERATURE(10614); MOVEMENT(12100); FOOD TEC1I-GENL S1UDS.METIIS(* 13502): FOOD TECH-FRUIT5.NUIS.VEGETABLES(* 13504 ); FOOD IECH-MALTS.BREWS.FERMENTATN(* 13512); FOOD TECH-FATS.01L5(-135M); root) UCH-EVALNS PIIYS.CHFM PROPS ( 13530) ; TOOD ' 0 I A Lt I 1 e5 B10SIS Previews 77'83/Jan BA7502 : RRM2402 ( See 65070228 EVALUATION OF A CALCIUM ALGINATE FILM FOR USE ON BEEF CUTS WILLIAMS S K: OBLINGER J L: WEST K L FOOD SCI. HUM. NUTR. DEP., INST. FOOD AGRIC. SCI.. UNIV. FLA.. GAINESVILLE. FLA. 32611. USA. J FOOD SCI 43 (2). 1978 292-296, Coden: JTDSA Language: ENGLISH Effects of a calcium alginate coating on retail beef pieces and steaks were studied. Microbiological analyses were performed on beef pieces following treatments with a calcium alginate coating; a 200 ppm H0C1 solution; a combination of the two; a col I form Inoculation and/or no treatment (control). Each sample was wrapped in a polyvinyl chloride (PVC) film and stored at 5.degree. C for up to 7 days. Rate of microbial growth for total and coll form counts on the meat was not significantly different with coated and uncoated meat samples. The HOC 1 treated meat hod significantly lower total microbial counts and col I form populations when compared to the calcium alginate or the H0C1-calcium alginate treated meat. Acceptance of tiie calcium alginate film involved retail display and organoleptic evaluations of 40 2.54-cm thick beef steaks. Steaks that received the calcium alginate coating were significantly lower in shrinkage loss. drip and degree of off-odor detected through 96 h storage when compared to uncoated steaks. Coating s I gn I f1 can11y prolonged muscle color through 96 h storage. No significant differences were observed between treatments for appearance. surface d)sco1ora.t I on, flavop, Juiciness, tenderness. overall acceptability or cooking loss. Descriptors: COLIFORM HYPO CHLOROUS - AC ID POLY VINYL CHLORIDE WRAP MICROBIAL GROWTH ORGANOLEPTIC EVALUATION Concept Codes: BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-CARBOHYDR. ( 10068); EXTERN EFF - TEMPERATURE( i 0614): EXTERN EFF-C0LD( 10616) ; EXTERN EFF-HOT( 1061B); FOOD TECH-MEAT,MEAT BY-PRODUCTS( * 135 16 ) : FOOD TECH-EVALN5 PHYS.CHF.M PROP S (* 13530 ) ; FOOD TECH-PREP,PROCESSNG.STORAGE(* 13532); MUSCLE SYST-PHYSIOL- ,BIOCHEM(17504); SENSE ORGANS-GENL SIUDS.METHS(20001); TEMPERATURE-GENL,METHS(2300I): MICROORGAN1 SMS-GENL.MI X ED.UNSPEC(29500): MICROBIOLOG APPARAT. - METHS,ME01A(32000); MED/CLIN MICROBIOL-GEN.ME III.TECH(36001): MED/CLIN MICROBIOL-BACTERIQLOGY(36002): PUB HEALTH MICROBIOl(374 00); FOOD/INOUS MICRO-FD/BEV SP CNTAM(*39002): DISINFECT ION.DISINFECTANTS.STERLf39500): PLANT PHYSIOL-CHEM C0NSTITUENTS(51522) BlosystomatIc Codes: MICROORGANI SMS-UNSPECIFIEO(01000); I3ACTERI A - UNSPECI F I E0( 06000) ; PHAEOPIIY T A ( 14 300) ; BOV l OAF ( 857 15 ) 65070171 EVALUATION OF THE BOTULISM HAZARD IN FRESH MUSHROOMS WRAPPED IN COMMERCIAL POLY VINYL CHLORIDE FILM k All 1 T r R D A; LILLY T JR; LYNT R DIV. MICROBIOL.. US DEP. HEALTH EDUC. WELFARE, FOOD DRUG ADM., WASHINGTON, D.C. 20204. USA, J roou PHOT 41 ( 2). 1978 120-121. Coderi: JFPRD Language: ENGLISH The botulism hazard In fresh mushrooms wrapped In commercial (c. BIOSIS 1982) (Item 609 of B5 R&S 2 186 polyv1ny1 chi or 1de (PVC) film appeal's to be minimal. At the end of their normal she If- 1 Ife. 1078 packages of PVC-wrappod mushrooms wore all free of botullnum toxin. Since Inoculated mushrooms are occasionally toxic (14 In 250 packages) when only one 1/8-in. hole was punched In the wrapper and none became toxic when 2 holes were present. It seems prudent to recommend that PVC-wrapped tills of mushrooms have 2 holes In the wrapper. Descriptors: SHELF LIFE TOXIN Concept Codes: BIOCHEM STUO-GENERAL(10060): BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACD(10064); FOOD TECH-FRUITS.NUT - S,VEGETABLES(* 13504); FOOD TECH-EVALNS PHYS.CHEM PROPS(13530) : FOOD TECH-PREP,PROCESSNG,STORAGES 13532); MUSCLE SYST-PATHOLOGY(17506); NERVOUS SYST-PATHOLOGY(20506); TOXICOL- -FOOD,RES IOS,ADDIT,PRESRV(*22502); BACTERIA-PHYSIOLOGY.BIOCHEMISTRY(31000): MED/CLIN MICROBIOL-B ACTERI OLOGY ( 36002 ) ; PUB HEALTH MICROBIOL(37400); FOOO/INDUS MICRO-FO/BEV SP CNTAM(*39002) B(osystemat(c Codes: EUBACTERI ALES(07200); BAS IDIOMYCETES(1- 5300) 65070140 ACCUMULATION OF SLIME IN DRAINAGE PIPES AND THEIR EFFECT ON FLOW RESISTANCE BLAND C E G; BAYLEY R W; THOMAS E V CLAY PIPE DEV. ASSOC. LTD.. LONDON, ENGL.. UK. J WATER POLLUT CONTROL FED 50 (t). 1978 134-143. Coden: JWPF A Language: ENGLISH Experimental work on the hydraulic roughness of clean new vitrified clay pipes carrying potable water Is detailed and the results for the 3 types of Interior finishes are given. Experimental work to determine the accumulation of microbiological slime on short lengths of drainage pipes of 6 different materials Is discussed and results of the dry weight accumulation are given. Also described are the experimental apparatus used to determine the hydraulic roughness of vitrified clay and unplasticized polyvinyl chloride pipes of 100 mm nominal bore when flowing full. The results of various velocities and duration of test are given. The mean hydraulic roughness as expressed as a k value In the Colebrook-WhIte equation for unp1 ast1c I zed poly-vinyl chloride and vitrified clay are practically the same after the pipes mature. Descriptors: MICROBIOLOGICAL Concept Codes: ECOLOGY-WATR RE5RCH, F-1 SHERY BI0L(O7517): BIOPHYS *BIOENGINC ERING(*10511); MOVEMENT(12100); MICROORGANIS MS-GENL . MI XED . UNSPEC ( 29500) ; FOOD/INDUS MICRO-BIOOEGRAO.DETER- (39006) BlosyslemntIc Codes: MICROORGANISMS-UNSPECIFIE0(O1000) 0 I ALJ 1e5: BIOSIS Previews 77-83/Jan BA7502:RRM2402(See 650701 16 DIFFERENTIAL TITRATION OF POTASSIUM BINDING TO MEMBRANE PROTEINS USING ION SELECTIVE ELECTRODES HASTINGS D F OEP. BIOCMEM,, DUKE UNIV. MED. CENT., DURHAM. N.C. 27710, USA . ANAL BIOCHEM ANBCA 83 (2). 1977 (RECD 1978) 416-432. Coden: Language: ENGLISH A differential titration technique was developed using 2 K* selective vallnomycln polyvinylchloride matrix electrodes. By using an Inactive membrane preparation In the reference half-cell during titration, the differential technique avoldod the previously difficult problem of nonspecific binding of K* to phosphate charges on the membrane phospholipids. The nonspecific binding of K* to the membrane fragments was the same In the reference half-cell and the sample half-cell: It did not contribute to the observed titration potential. This technique -was used to measure high affinity K* binding to membrane - bound (Nat, K*)-ATPase (from Squalus ocanthlas rectal gland], which could be described by the following constants: K + site concentration, 17.8 .*-. 0.4 nmol of K + sites/ml of solution; Kd = 42 .+-. 2 ,mu.M at ionic strength 0.1, In 97 mM choline at pH 7.4, on a preparation containing 2.52 mg of proteln/ml at (Nat, Kt)-ATPase specific activity of 1400 .mu.mol mg-1 .cntdot. h-1. Descriptors: SOUALUS-ACANTHI AS RECTAL GLAND S00IUM POTASSIUM ATPASE POTASSIUM SELECTIVE VAL1N0MYCIN POLY VINYL CHLORIDE ELECTRODE Concept Codes: ECOLOGY-WATR RESRCH.FISHERY BI0L(07517): BIOCHEM METH-MINERALS( 10059): BIOCHEM STUD-PROTEI NS.PEPTIDES.- AMINO ACD(10064); MINERALS(10069); BIOPHYS-GENERAL BIOPHYS TECH(t10504); BIOPHYS- MEMBRANE PHENOMENA(* 10508): ENZYMES-MET- H0DS( * 10804.) ; DIGESTIVE S YST - PHY S IOL . B I OCHEM ( 1 4004 ) ; PHARMACO- L-GENERAL STUD IES(22002); CHEMOTHERAPY-GEN STUD.METH.METAB(38 502 ) BlosystematIc Codes: CI10NDRICHTHYES(85202) 65069176 TOTAL SYNTHESIS OF BETA LACTAMASE INHIBITORS RELATED TO CLAVULANIC-ACID HUNT E: BENTLEY P H; BROOKS G; GILPIN M L BEECHAM PHARM. RES. OIV. , BROCKHAM PARK. BE TCI IWORTH RH3 7AJ, SURREY, ENGL,. UK, J CHEM SOC CHEM CQMMUN Coden: JCCCA (24). 1977 (RECO 1978) 906-907. Language: ENGLISH (E)- 3-Me thoxycarbonylmethy1ene-7-oxo-4-oxa-1-azablcyclo[3.2- .0]heptane, Its geometric Isomer and a related vinyl chloride were obtained by a 3-step synthesis from 4-mo t hy1thloazet1dln-2-one. Descriptors: METAB-DRUGS Concept Codes: COMPARATIVE BIOCHEM-GENL STUD IES( 10010): BIOCHEM METH-GENERAU* 10050); BIOCHEM STUD-GENERAL( 10060): BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACD(I00G4); BIOPHYS-MOLE - CUL PROP,MACROMOLEC(10506 ) : ENZYMES - METHODS( 10804); ENZYMES-- (c. BIOSIS 1982) (Item 612 of R&S 13854 2 187 PHYSIOLOGICAL STUDIES(* 10800): PATHOLOGY-TlIERAPY( 1 25 12 ) : MET ABOLISM-GENL STUD,METAB PATHW(13002): PHARMACOL-GENERAL STUD IES(* 22002); PHARMACOL-DRUG METAB,METAB ST IMU(22003); BACTERIA-PHYSIOLOGY,BIOCHEMISTRY(*31000): MED/CLIN MICROBIOL-- BACTERlOLOGYf 36002): CHEMOTHERAPY-ANT IBACTERIAL AGNTS(*38504 ) BlosystematIc Codes: BACTERIA-UNSPECIFI ED(06000) 6506807 1 OCCUPATIONAL ACRO OSTEOLYSIS GAMA C: MEIRA J B B RUA INHAMBU 156, INO IANOPOLIS, SAO PAULO 04520. BRA2. J BONE JT SURG AM VOL 60 (1). 1978 86-90. Coden: J0JSA Language: ENGLISH Occupational acro-osteolysis Is a serious disease definitely related to the inhalation of agents Involved In the po1ymerIzatIon of vinyl chloride. After variable periods of latency. the more or less characteristic clinical picture appears. A Raynaud's phenomenon Is usually a premonitory sign Indicating that alterations In bone will probably ensue. Scleroderma-1 Ike skin lesions and systemic Involvement of variable degree occur frequently. The pathophysiology of the disease Is unknown, but obstructive lesions of small peripheral arteries are thought to cause osteolysis of the distal phalanges of the fingers. Descriptors: HUMAN VINYL CHLORIDE INHALATION RAYNAUDS PHENOMENON SKIN LESIONS SYSTEMIC INVOLVEMENT ARTERIAL LESIONS Concept Codes :' SOCIAL BIOL/HUMAN ECOLOGY (05500) ; BIOCHEM-GASES(IOO12); BIOCHEM STUD-GENERAL(10060): CHORDATE BODY REGNS-EXTREMITIES(*11318): PATHOLOGY-GENERAL STUDIESM25- 02); CARO IOVASC SYST-BLD VESS PATHOL( 14508): RESPIRATORY SYST-GENL STUD,ME THS(16001): BONE.JNTS.FASC.CONN/AO IP-PATHOL(- *18006): INTEGUMENT SYST-PATHOLOGY(18506): IMMUNIZ.INFECT.THE RAP(22100); ROUTES OF TOXICOL-ENVIRONMNTL,INOUSTR(*22506): NEOPLSMS/NEOPL AGNTS'CAR- CINOGENS{24007); ENVIRON HEALTH-OCCUPATNL HEAL1H(37013): ENVIRON HEA1.1H-A1R.WATR.SL POLLNf * 370 1 5 ) BIosystematIc Codes: HOMINIDAE(862 1 5 ) D IALO 11e5: BIOSIS Previews 77-83/Jan BA7502;RRM2402(See Flle5S) (c. BIOSIS 1982) ( R&S 138542 3614 25J anB3 2108 650658 15 MUTAGENICITY OF WASTE PRODUCTS FROM VINYL CHLORIDE INDUSTRIES RANNUG U: RAMEL C WALLENBERG LAB. . LILLA FRESCATI. S-104 05 STOCKHOLM 50. SWED. J TOXICOL ENVIRON HEALTH JTEHD Language: ENGLISH 2 (5). 1977 1019-1029. Coden: Tlie by-product from vinyl chloride production, EDCfethylene dI chi or Ide]-tar, Is a complex mixture of short-cha1ned chlorinated aliphatic hydrocarbons. This mixture was tested for mutagenicity by the Ames Sa1mone11 a/mamma 11 an mlcrosome method. Since most of the components In the tar are poorly soluble In water, 3 agents were used as solvents or emulsifier: ethanol, DMSO [dimethylsulfoxIde], and Tween 80. The results with all these agents showed that EDC-tar contains direct as wol1 as Indirect mutagenic const1tutents. The mutagenic effect observed In the test could not be duo to 1 of the main components. EDC (1,i-d1ch1oroethane). This substance showed a weak mutagenic effect. but only at higher concentratIons than could be available In the highest conccntratIon tested of the tar. Although the microsomal system enhanced the mutagenicity of EDC-tar and 1.2-dlch1oroethane, this enhancement was dependent on NADPH in the case of EDC-tar but Independent of NADPH with 1 ..2-d I ch 1 oroe t hane. The Salmonella mammalian mlcrosome method seems to be a suitable tool for mutagenicity screening of Complex chemical mixtures and Identification of mutagenic constituents In such mixtures. Descriptors: SALMONELLA MAMMALIAN MICROSOME METHOD ETHYLENE 01 CHLORIDE TAR 1 2 DI CHLORO ETHANE CARCINOGENS NADPH Concept Codes: CYT0L0GY/CYT0CHEM-AN1MAL(02506): BIOCHEM METH-GENERAL( 10050): BIOCHEM STUD-GENERAL( 100G0): BIOCHEM STUD -NUCL ACD.BURNS.PYRM( 10062); BIOPHYS-MOLECUL PROP.MACROMO- LEC( 10506): ENZYMES-GEN,COMPAR STUD,COENZYMS(* 10802): METAROL- ISM-GENL STUD.METAB PATHW(* 13002); TOXlCOL-ENVIRONMNTL . INDUST- R(*22506); NEOPLSMS/NEOPL AGNT5-B1OCHEM(*24006); NEOPLSMS/NEO- PL AGNT S-CARC I NOGENS(* 24007): BACTERIAL AND VIRAL GENETICS( *31500); MICROBIOLOG APPARAT.METMS.MED I A(32000); IN VITRO STUDS-CEUIULR,$UBCELL(32GOO); ENVIRON I IEALTH-OCCUPATNL HEALTMt*37013) Blosystematlc Codes: EUBACTERI ALES(07200); MAMMAL I A-UNSPECIFIEO AND EXTINCT!05700) vinyl chloride factory, people employed In the laboratory of another vinyl chloride plant and 10 controls from outside the factory environment were examined for the presence of chromosome aberrations In blood lymphocytes. Chromosome anomalies such -as fragments. rings, translocations and dicentrics were observed In most of the workers from the polymerization department. The medical history of these workers shows that they received frequent radiographs of the hands. feet, vertebral column and digestive tract. It Is Impossible to determine whether these chromosome anomalies resulted from vinyl chloride exposure. Descriptors: HUMAN CARCINOGEN FRAGMENTS RINGS TRANSLOCATIONS DICENTRICS Concept Codes: . PHOTOGRAPHY-METHS.MATLS,APPARAT(01012); CYTOLOGY/CYTOCHEM-HUMAN!02508); GENETICS/CYTOGENET-HUMAN!*03508); SOCIAL BIOL/HUMAN EC0L0GY(0- 5500): RADIATION BIOL-RAOTN,ISOTOP TECH(06504); RADIATION BIOL-RADTN EFF.PR0TECT(06506); BIOCHEM METH-GENERAL!10050): BIOCHEM STUD-GENERAL(10060); BIOPHYS-MOLECUL PROP.MACROMOLEC(- 10506); ANATOMY/HISTOL-RADIOLOGIC!1110G): CHORDATE BODY REGNS-BACK/BUTTOCK! 1 1310); CHORDATE BODY REGNS-EXTREMITIES( 1 1- 318): PATHOLOGY-DIAGNOSTIC!12504); DIGESTIVE SYST-GENL STUDS.METHS(14001); BLOOD/BODY FLDS-BLOOD CELL STUDS(15004); BLOOD/BODY FLUS-LYMPHAT T15S.RES(*15008); TOXICOL-ENVIRONMNTL- ,INDUSTR(* 2250G); NEOPLSMS/NEOPL AGNT5-CARC1 NOGENS(`24007); TISS CULTURE-APPARAT.METHS,MEDIA!32500); ENVIRON HEALTH-OCCUP- ATNL HEALTH!`37013) Blosystematlc Codes: H0MINIDAE(86215) 65065809 . CYTO GENETIC INVESTIGATIONS EXPOSED TO VINYL CHLORIDE LEONARD A; DECAI G: LEONARD E NICAISE C` ON LYMPHOCYTES D; LETEVRE M J: FROM WORKERS DECUYPER L J; DEP. RADI0B10L.. CENT. ETUD. KERNENERG.. B 2400 MOL. BELG. ENERG. NUCL.-STUD IECENT. J TOXICOL ENVIRON HEALTH JTEHD 2 (5). 1977 1135-1141. Coden: Language: ENGLISH Eleven male workers from the polymerization department of a DI AI^^F I 1e5: BIOSIS Previews 77-83/Jan BA7502;RRM2402(See 65061919 METABOLISM OF VINYL CHLORIDE DESTRUCTION OF THE HEME OF HIGHLY PURIFIED LIVER MICROSOMAL CYTOCHROME P-450 BY A METABOLITE GUENGERICH F P: STRICKLAND T W DEP. BIOCHEM.. VANDERBILT UNIV. SCH. MED., NASHVILLE. TENN. 37232. USA. MOL PHARMACOL 13 (6). 1977 993-1004. Coden: MOPMA Language: ENGLISH The NADPH-dependent. vinyl chloride-mediated destruction of cytochrome P-450 was demonstrated In rat liver mlcrosomes and In highly purified reconst1tuted enzyme systems containing NAOPH-cytochrome P-450 reductase (NADPH:ferr 1cytochrome ox 1doreductase. EC 1.6.2.4) and cytochrome P-4S0. This loss of cytochrome P-450 could be attributed to heme destruction, but not to lipid peroxidation or binding of electrophiles to free sulfhydryl groups. The system required all components necessary for m1xed-functIon oxidation. Including 02, and was Inhibited by CO, suggesting strongly that oxidative metabolism of vinyl chloride by cytochrome P-450 Is necessary for the observed destruction. The NADPH-cytochrome P-450 reductase-cata Iyzed destruction of free and cytochrome P-450-bound home was also observed In reconstItuted systems in the absence of vinyl chloride. Inhibition experiments with CO and catalase suggest that the vinyl chloride-mediated destruction of cytochrome P-450 heme differs from these processes. Two proposed metabolites of vinyl chloride, vinyl chloride epoxide and 2-ch1oroaceta1dehyde, do not appear to be responsible for the heme destruction. Evidence for the involvement of free rad Ica1s.cou1d not be demonstrated when the reaction was examined by EPR spectroscopy or when attempts were made to Inhibit cytochrome P-450 destruction with rad Ica1 -trapp1ng agents. Descriptors: RAT NADPH CYTOCHROME P-450 REDUCTASE EC-1.6.2.4 Concept Codes: BIOCHEM-CASES( 10012); BIOCHEM METH-GENERAL( I - 0050): BIOCHEM STUD-GENERAL( 100G0); BIOCHEM SUJO-NUCL ACO,PURNS.PYRM( 10062); BIOCHEM STUD-PROTEI NS,PEPTIOES.AM I NO ACD( 10064); BIOCHEM STUD-PORPHYRNS.BILE PIGM( 10065 ) ; BIOCHEM STUD-LIPIDS!100G6): BIOPHYS-GENERAL BI0PHY5 TECH(10504); B I 0PI1YS - MEMBRANE PHENOMENA ( 10508 ) ; ENZ Y ME S - PI IV S 1 OLOG1 C AL STUDIES! - 10800 ); METABOLISM-GENE STUD,MET AH PATHW(* 1 3002): METABOLISM-LIPIDS( 13006) ; METABOLISM-PORPHYRI NS.BILE P1GMN( * I- 3013):. DIGESTIVE SYST-PHYSIOL.BIOCHEM(14004); TOXI COL-GENL/E- XP STUDS.METHSC`22501 ); IN VITRO STUDS-CELLULR.SUBCELL{32600) Blosystomat1c Codes: MURIDAE(86375) Ft&S ^38543 Cc. BIOS. 858) User 3614 n83 2 189 polyvinyl chloride materials, were determined. The separation occurred in an isothermic regime of 160-240.degree. C. Nonsyinmetrlea 1 dlalkyl osters contained a significant quantity of corresponding symmetrical. esters. The use of buty1dodecy1phtha1 ate entails the problem of the migration of significant quantities of dIbuty1 pittha1 ate Into the contacting medium. The data may facilitate the Identification of complex esters of dlcarbonlc acids. and their determination during m 1 gra tI on. Descriptors: POLY VINYL CHLORIDE PLASTICIZER MIGRATION Concept Codes: BIOCHEM METH-GENERAL(* 10050); BIOCHEM STUD-GENERAL(10060); BIOPHYS-GENERAL BIOPHYS TECH!10504): B10PHY5-MOLECUL PROP.MACROMOLEC(* 10506); EXTERN EFF-HOT( 106 18 ) MOVEMENT!12IOO): TOXI COL-GENL/EXP STUDS.METHS(*2250 1 ); T E MPE RATURE-GENL.ME THS(23001) 65061904 A GAS LIQUID CHROMATOGRAPHY METHOD FOR MONITORING VINYL CHLORIDE IN DRUGS AND IN POLY VINYL CHLORIDE DRUG CONTAINERS/ WATSON d R: LAWRENCE R C: LOVERING E G PHARM. CHEM 01V.. DRUG RES. LAB.. HEALTH PROT. BRANCH. OTTAWA, ONT. K1A 0L2. CAN. CAN J PHARM SCI 12 (4). 1977 (RECD 1978) 94-97. Coden: CNJPA Language: ENGLISH A gas chromatographic method Is described for monitoring vinyl chloride levels In drugs and polyvinyl chloride drug containers. After suspension of the powdered drug material or dissolution of the polymer In 1.2-dI chioroethane. an aliquot of the supernate or homogeneous solution Is Injected (absolute Injection technique) Into a gas chromatograph equipped with a flame ionization detector and a me thy 1sI 1 1 cone column. The vinyl chloride. If present. Is quantitated by simple computation of Its peak area relative to a response factor, accurately predetermined using solutions of pure vinyl chloride gas and commercial vinyl ch1 or 1de-a Ir,mlxtures In 1.2-dI chioroethane. The limit of vinyl chloride detectability Is about 0.2 ppm for polyvinyl chloride containers and about 10-30 ppb In the case of drug dosage forms. Concept Codes: BIOCHEM METH-GENERAL(*10050); BIOCHEM STUD-GENERAL( 10060); BIOPHYS-GENERAL BIOPHYS TECH(* 10504): MOVEMENT 12100): PHARMACOL-GENERAL STUD IES(* 22002); TOXICOL-G- ENL/EXP STUDS.METIIS(*22501); TOX1 COL-PHARMACOLOG1 CAL(*22504 ) 65061915 THE GAS. LIQUID CHROMATOGRAPHIC SEPARATION OF SOME COMPLEX ESTERS OF DI CARBOXYLIC ACIDS GORTSEVA L V; KOFANOV V I: RAPAPORT L I ALL-UNION RES. INST. HYG. TOXICOL. PEST. POl.YM. PLAST.. KIEV. USSR. GIG SANIT (10). 1976 (RECD 1977) 64-65. Coden: GISAA Language: RUSSIAN Conditions for the GLC separation of complex esters of adipic, sobaclc and o-phthallc acids, used as plasticizers of DIAL I 1e5: BTOSIS Previews 77-83/dan BA7502;RRM2402(See F ) (c. R&S 138544 ) Of 858) User 3614 2 190 6SOGOOOO URINARY GLYCOSAMINO GLYCAN PATTERNS IN ANGIO SARCOMA OF THE LIVER CURRAN K L; KUPCHELLA C E: TAMBURRO C H CANCER CENT., UNIV. LOUISVILLE. LOUISVILLE. KY. 40201. USA. CANCER (PHILA) Codon: CANCA 40 (6). 1977 (RECD 1978) 3050-3053. Language: ENGLISH G1ycosam1 nog 1 yeans extracted from 24 h urine specimens, from patients with hepatic angiosarcoma and from normal/controls wore separated as cety1pyr1d1nlum complexes Into hyaluronic acid, chondroltln sulfate and heparin fractions. then further separated and character 1 zed by anion-exchange chromatography and hya1uron1dase susceptibility. The chromatograph1c pattern of the urinary chondroltln sulfate fraction In patients with angiosarcoma of the liver differed from those of controls In that there was a relative Increase In the total amount of uronlc acid In a hya1uron1dase-res 1stant fraction and a decrease In a fraction susceptible to hya1uronIdase digestion. These changes appeared to become more pronounced with advancing disease. Chromatograph1c patterns and determinations of hya1uron1dase susceptibility Indicated that the resistant fraction was heparan sulfate and that the susceptible fraction was chondro)t1n-4-sulfate and/or chondro 1 t In-6-su 1 fate. [These observations constitute a promising lead In early detection of vinyl chloride Induced llve'r disease.] Descriptors: HUMAN VINYL CHLORIDE CARCINOGEN HYALURONIDASE CHROMATOGRAPHY HEPARAN SULFATE CHONDROI TIN SULFATE URONIC-ACID HYALURONIC-ACIO Concept Codes: SOCIAL BIOL/HUMAN ECOLOGY(05500); CLIN BIOCHEM-GENL STUD IES(* 10006); BIOCHEM METH-CARBOHYDRATES( 1005 - 8): BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACD( 10064): BIOCHEM STUD-CARBOHYDR. ( 10068); BIOPHYS-GENERAL BIOPHYS TECH< 10504 ); ENZYMES-METHODS(10804); MOVEMENT(12100); PATHOLOGY-DIAGNOSTIC- (*12504 ): METABOLISM-CARBOl IYDRATES(* 13004 ); OICESIIVC SYST-PAtl IOLOGY( * 1400G ) ; CAROIOVASC SYST-BLD VESS PA n IOL( 1450- 8): URIN SYST/EXT SECR-PHYSL.BIOCHEM( 15504 ); TOXI COL-GENL/EXP STUDS.METHS( *22501); TOX I CQL-ENVIRONMNXL.I NOUSTR(2250G); NEOP- LSMS/NEOPL AC.NTS-DIAGNS ME TH( 2400 1 ) : NEOPLSMS/NEOPL AGNTS-CARC!NOGENS( *24007) ; ENVIRON HE ALTH-OCC.UP ATNL HE ALTH( 37 - 013): ENVIRON HEALTH-AIR.WATR.SL P0LLN(37015) Blosystemat Ic Codes: HOMINIDAE(862 15) consistently showed 2- to 10-fold higher values of extractable ATP, rates of 02 utilization. activities of alkaline phosphatase and phosphodiesterase and the mucopeptlde cell wall component muramlc acid than did the polyvinyl chloride needles, during a 14 wk Incubation In a semltroplcal estuary. The higher activities by the mlcroblota of the bIodegradab1e substrate correlated with estimates of the microbial density from scanning electron microscopy.' The microbial community associated with the nondegradable substrate showed minimal activity of .beta.-D-ga1actos1dase. .beta.-D-glucosIdase and .a Ipha.-O-mannos1dase In contrast to the biota of the degradable substrate, which showed 10- to 100-fold higher activities of these glycoesterases. These enzymes logically could be Involved in catabolism of the carbohydrate polymers of the detritus. Assuming equivalent rates of predation. a surface that Is also a util liable substrate supports a 3- to 5-fold more active microbial population. Descriptors: PINUS-ELLIOTT11 POLY MURAMIC-ACID ALKALINE PHOSPHATASE PHOSPHO DI GALACT0S1DASE BETA-D GLUCOSIDASE ALPHA-D TROPICAL ESTUARY VINYL CHLORIDE ESTERASE BETA-D MANNOSIOASE SEMI Concept Codes: ELECTRON MI CROSC.OPY (01058 ): ECOLOGY-OCEANOGR APHY . L IMNOLOGY( *075 10) ; ECOLOGY-WATR RESRCH.FISHERY BI0LI0751- 7); COMPARATIVE BIOCHEM-GENL STUD IES( 10010); BIOCHEM~GASES(ID- 012): BIOCHEM METH-PROTNS.PEPTOS,AM AC(10054); BIOCHEM STUD-GENERAL(10060): BIOCHEM STUD-PROTEINS.PEPTIDES.AM I NO ACD( 10064): BIOCHEM STUD-CARBOHYDR.(10068): ENZYMES-GEN.COMPAR STUD.COENZYMSf10802): ENZYMES-METHODS(10B04): ENZYMES-PMYS10 - LOGICAL STUD IE S(* 108OB); METABOLISM-GENL STUD.ME T AB PATHW(13002): METABOLISM-CARBOHYDRATES(* 13004); MICROORGANIS- MS-GENL.MIXED,UNSPEC(*29500); MICROBIOLOG APPARAT.METHS,MED 1 A- (32000): FOOD/INDUS MICRO-BIODEGRAD,DETER(*39006) BlosystematIc Codes: MICROORGANISMS-UNSPECIFI ED(O1000): CONIFEROPSIOA (CONITERAE)/25102) G5058305 EFFECTS OF SUBSTRATE BIO DEGRADABILITY ON ACTIVITY OF THE ASSOCIATED ESTUARINE MICRO BIOTA BOBBIE R J: MORRISON S d; WHITE D C THE MASS AND 01.P. BIOL. SCI., FLA. STAIE UNIV., TALLAHASSEE. FLA. 3230G. USA . Al'IM At MID ENVIRON MICROBIOL 35 (1). 19711 1711-1114, Ccxlnn: Language: ENGLISH Multiple biochemical assays of microbial mass and activities were applied to the estuarine detrttal mlcroblota colonizing morphologically similar polyvinyl chloride needles and needles from slash pine (Plnus elllottll). Biodegradable pine needles DIA BIOSIS Previews 77-83/Jan BA7502;RRM2402(See I R&s 138545 ) (Item 622 of 858) User 3614 25JanB3 2 19 t 65055803 EFFECTS OF POLY VINYL CHLORIDE INGESTION BY DOGS JOHNSON W S; SCHMIDT R E VET. SCI. 01V. , COMP. PATHOL. BRANCH, US AIR FORCE AEROSP. MED., BROOKS AIR FORCE BASE. TEX. USA. AM J VET RES 38 (11). 1977 1891*1892. Coden: AJVRA Language: ENGLISH SCH. Polyvinyl chloride (PVC) acrylic thermoplastic sheeting was fed to 6 dogs to determine If Ingestion during periods of normal transit of military working dogs would be toxic and affect the safety of this material for construction of shipping containers. The test dogs were fed PVC acrylic (0.125 g/kg of body wt; by gelatin capsule) twice each day for 5 days: for 2 dogs, the test material was In a shredded form; for 2 dogs, the material was diced: and for 2 dogs. It was powdered. Two other dogs were used as controls. Dogs were observed for clinical signs, and feed consumption and body weights were recorded. Blood and urine samples wero recorded. Blood and urine samples were examined. All animals were necropsled .apprx. 10 days after the feeding was stopped. Clinical or pathologic Indication of a toxic effect of PVC was not seen within the time limits of the study. Descriptors: FEED CONSUMPTION WEIGHT BLOOD URINE SHIPPING CONTAINER SAFETY Concept Codes: BEHAVIOR BIOL- ANIMAL BEHAVIOR(07003); BIOCHEM STUD-GENERAL(100G0): PHYSIOLOGY-GENERAL STUD I S( 1 2002); M0VEMENT( 12100); NUTR1T1ON-GENL.NUTR STATUS,METHS( 1 3202); BLOOD/BODY FLOS-BLOOD,LYMPH STUD(15002): URIN SYST/EXT SECR-PHYSL,BI0CHEM(15504); DENTAL/ORAL BIOL-GENL STUD.METIIS(1- 900 1 ); ROUTES OF IMMUNIZ. INFECT.THERAP(22100): TOXI COL-ENVIRONMNT L,INDUSTR(22506); TOXI COL-VETERINARY(* 22508); VETERINARY SCI-GENL STUDS.METHS(*38002) Blosystemat1c Codes: CANIDAE(85765) DIALYSIS EXTRACORPOREAL CIRCULATION UMBILICAL CATHETERIZATION ERYTHROCYTE METABOLISM Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(02506); BIOPHYS-MOL- ECIJL PROP.MACR0M0LEC( 10506) ; MOVEMENT ( 12 100) : METABOL 1 SM-C.ENL STUD.METAB PATHWf* 13002); CARDIOVASC SYST-PHYSIOL.BIOCHEM( 145- 04); BLOOD/BODY FLDS-GENL STUDS.METHS(15001); BLOOD/BODY FLDS-BLOOD CELL STUDS(*15004); URIN SYST/EXT 5ECR-GEN STUD.METH( 15501); REPRODUCT SYST-PATHOLOGY( 16506); BONE,JNTS.- F A SC,CONN/ADIP-PHY,BCH( 18004): NERVOUS SYST-PHYSIOL.BIOCHEM(2 - 0504); TOXICQL-GENL/EXP STUDS.METHS(*22501); TOXI COL-ENV1RONM- NTL,INDUSTR(22506): PEDIATRICS(25000); DEVELOPMNTL BIOL-GENL.- DESCRIPTIVE(25502): DEVELOPMNTL BIOL-EXPERIMENTAL(25504): TISS CULTURE-APPARAT.METHS.MEDIA(32500): IN VITRO STUDS-CELLULR.SU BCELL ( 32600) B losystemat1c Codes: GALL I FORMES(85536); HOMINIDAE(862 15); MURIDAE(86375) 65055737 POLY VINYL CHLORIDE PLASTICS THE ENEMY WITHIN BELL F P DEP. PATHOL., MCMASTER UN1V., HAMILTON, ONT., CAN. ARTERY 2 (5). 1976 (RECD 1977) 384-3B9. Language: ENGLISH Coden: ARTED This editorial Illustrated the Inherent danger In using polyvinylchloride (PVC) plastics In medicine and research. PVC plastics contain agents called plasticizers such as dl-2-ethyl hexyl phthalate (DEHP). DEHP Is toxic to chick embryo heart colts. cultured mouso fibroblast L-cells and neonatal rat cerebellar fibroblasts. DEHP also apparently modifies erythrocyte metabolism and alters platelet adhes I venev's ns well as the survival of platelets stored frozen In PVC bags. Intake and accumulation of phthalates from plastic medical devices occurs In patients undergoing a variety of medical treatments such as blood transfusion, heamod1 a 1ys1s. extracorporeal circulation and umbilical a the ter 1zatIon. The use of PVC plastics should be curtailed until Its chemical constituents are Identified and their biochemical and pharmaco1og1ca1 effects are evaluated. Descriptors: HUMAN CHICK RAT MOUSE BLOOD T RANSFUSI ON HEMO I DIAL' lloS: BIOSIS Previews 77-83/Jan BA7502;RRM2402 ( See F G50557 32 A HYGIENIC ASPECT Of THERMOPLASTIC RESINS AS FOOD PACKAGING MATERIALS KWON S P; CHUNG V; KIM S-A; 5HIM K S COLL. MED.. YONSEI UNIV.. SEOUL. KOREA. KOREAN CENT J MED Coden: CHUIA 3t (4). 1976 (RECD 1977) 335-343. Language: KOREAN The leaching of polyvinyl chloride (PVC), polyethylene (PE), po1ypropy1ene (PP), po1yvIny1 I dene chloride (PVDC) from food packaging materials and PVC from blood storage bags was studied. PE and PP and PVC of blood storage bags were not detected In Pb and Cd compounds. The PVC level of food packaging materials was detected. This level was below the permlssable level of 100 ppm. Phthalates plasticizer from PVC food containers and blood storage bags were measured In the range of 0.00-0.44 .mu.g/g and 0.032-0.073 .mu.g/g, respectively, when the container held a saline solute at 30.degree. C for 1 day and 3.30 .mu.g/g and 0.0-9.23 .mu.g/g, respectively, when the container held 4% acetic acid solute at 60.degree. C for 1 day. The ability of these packaging materials to protect food contents from degradation by light was examined. The castod propylene transmitted all UV light, the oriented propylene transmitted 50% and PVC banned under 270 m.MU. UV. Descriptors: POLY VINYL CHLORIDE POLY ETHYLENE POLY PROPYLENE POLY VINYLIDENE CHLORIDE BLOOD STORAGE BAGS LEAD CADMIUM UV Concept Codes: RADIATION BIOL-RADTN EFF.PROTECT(06506): MINERALS! 10069); BIOPHYS-MOLECUL PROP.MACROMOLEC(*10506); BIOPHYS-BIOENGINE ERING( 10511): EXTERN EFF-LIGHT.DARKNESS( 1060- 4); M0VEMENT( 12100): FOOD TECH-EVALNS PHYS.CMEM PROPS(* 13530); F000 TECH-PREP.PROCESSNG.STORAGE!* 13532); BLOOD/BODY FLDS-GENL STUDS.METHS!* 15001): TOXI COL-GENL/EXP STUDS,METHS(*22501 ); TOXICOL-FOOD,RE SIDS.ADD IT,PRESRV( *22502 ) 65050039 MEDICAL APPLICATION OF SYNTHETIC MEMBRANES NAKABAYASHI N INST. MED. DENT. ENG.. TOKYO MED. DENT. UNIV.. CHIYODA-KU, TOKYO, JPN. MEMBRANE 2 (5). 1977 29-37. Coden: MAKUD Language: JAPANESE Artificial memoranes used as artificial skin and artificial kidneys are discussed with special reference to their abilities of passing substances. H20 vapor passing rate of normal skin and diseased skin and various polymer membranes such as vinyl 1 dene chloride, polyethylene, vinyl chloride. Cellophane. polyester, polycarbonate, polyamide, polyvinyl alcohol, polypropylene, properties of collagenfc membranes and hurnod I a 1 y z I ng membranes Including cuprophnne and polyacrylonitrile are discussed. Descriptors: VINYLIDENE CHLORIDE POLY ETHYLENE VINYL CHLORIDE CELLOPHANE POLY ESTER POLY CARBONATE PqLY AMIDE POLY VINYL ALCOHOL POLY PROPYLENE HEMO DIALYSIS C0LLAGEN1C MEMBRANE CUPROPHAN POLY ACRYLONITRILE \38546 Item 624 of 858) User 3614 25jan83 . 2192 concept Codes: BIOCHEM-PHYSIOLOGL WATER STUD( 10011): BIOCHEM METH-GENERAL!10050): BIOCHEM STUD-GENERAL(10060); BIOPHYS'GEN- ERAL BIOPHYS TECH(10504); BIOPHYS-MOLECUL PROP.MACROMOLCC(10- 506); BIOPHYS-BIOENGI NEERING(* 10511); MOVEMENT(12100); CARD IOVASC SYST-PHYSIOL.BIOCHEM! 14504); CARDIOVASC SYST-HEART PATHOLOGY!14506); BLOQO/BODY FLDS-GENL STUDS.METHS(15001); URIN SYST/EXT SECR-GEN STUD.METH(* 15501): INTEGUMENT 5YST-GENL STUDS,METHS(* 18501) 65049404 PARTICLES OF DI-2 ETHYLHEXYL PHTHALATE IN INTRA VENOUS INFUSION FLUIDS MIGRATING FROM POLY VINYL CHLORIDE BAGS IIORI OKA M; AOYAMA T; KARASAWA H FAC. MED., HOSP. PHARM.. KYUSHU UNIV., MAI DASHI 3-1-1, HIGASHI, FUKUOKA 812. JPN. CHEM PHARM BULL (TOKYO) 25 (7). 1977 1791-1796. Codon: CPBTA Language: ENGLISH Mechanical measurement of particles In the Infusion fluid contained In a polyvinyl chloride (PVC) bag revealed the presence of a large number of particles and principle of these particles was examined. It was thereby confirmed that the majority of particles In the solution contained In a PVC bag are liquid particles of dl(2-ethy1hexy1) phthalate (DEHP) used as a plasticizer for PVC. and these particles adhere to the Inner wall of the bag or float In the solution. When the PVC bag Is shaken before sampling the fluid, the liquid particles of DEHP are liberated and dispersed as mIcropartIc1es which are cotinted as particles by HIAC automatic counter. but not observed on membrane filter under a microscope. Detecting of such a liquid particle. a considerable difference between the results from a mechanical method and that from a microscopic observation was pointed out. [With the progress In modern medicine, a large quantity of l.v. Infusion fluids Is used for treatment, and the effect of such an Infusion on patients, especially the hazardous effect of foreign particulate matter present In Infusion fluids, has become a great problem.] Descriptors: HUMAN MICROSCOPIC OBSERVATION Concept Codes: MICROSCOPY-GENL.SPECL TECHNIOUES(01052); CLIN BIOCHEM-GENL STUD IES(*10006); BIOCHEM STUD-LIPIDS( 10066); BIOPHYS- GENERAL BIOPHYS TECH( 10504); CARDIOVASC SYST-GENL STUDS.METHS!14501); BLQOO/BOOY FLDS-GENL STUDS,METHS(*15001); ROUTES OF IMMUNI2.INFECT.THERAP(22100): TOXI COL-GENL/EXP STUDS.METHS!*22501) BlosystematIc Codes: HOMINI DAE(86215) DIAL He5: BIOSIS Previews^77-83/Jan BA7502: R&S 138547 BIOSIS 1982) (Item 627 of 858) User 3614 25JanB3 2 193 65049265 VINYL CHLORIDE ITS IMPACT ON OCCUPATIONAL MEDICINE PRACTICE IN IRAN ARYANPUR d PUBLIC HEALTH OCCUP. MED. SERV.. NATL. IRANIAN OIL CO.. P.O. BOX 1863. TEHRAN. IRAN. J OCCUP MEO 19 (10). 1977 689-692. Language: ENGLISH Coden: JOCMA Awareness that VCM (vinyl chloride medicine] has been demonstrated to be a carcinogen producing a rare tumor, angiosarcoma, has led the company to tighten Its medical monitoring and Industrial hygiene controls. A temporary TLV [threshold limiting value] was established for VCM at 25 ppm consistent with the operating procedures of the company and local geographical conditions. The potential harm from Industrial chemicals has stimulated the government and the company to support further control of Inplant and outplant environmental hazards from Industrial operations. Descriptors: HUMAN CARCINOGENESIS ANGIO SARCOMA Concept Codes: SOCIAL BIOL/HUMAN ECOLOGY(05500); 8I0CHEM STUO'GENERALt10060); CARDIOVASC SYST-BLD VESS PATHOL(H508): TOXICOL-ANT I DOTES.PREVENTIVE(22505); TOXICOL-ENVIRONMNTL.INDUSTR(*22506); NEOPLSMS/NEOPL AGNTS-CAR- CINOGENS(*24007); ENVIRON HEALTH-OCCUPATNL HEALTH(* 37013); ENVIRON HEALTH-AIR,WATR.SL POLLN(* 37015) Blosystema tIc Codes: HOMINIDAE(86215) p. than 90% accurate In distinguishing between carcinogens and noncaccI nogens. Descriptors: HAMSTER RAT LIVER S.-9 MIX BHK-21-C-13 KIDNEY CELLS VINYL CHLORIDE GAS CARCINOGEN Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(*02506); MATHEMATIC BIOL/STATISTIC METH(04500); BIOCHEM-GASES(10012); BIOCHEM METH-PR0TN5.PEPTDS.AM AC(10054); BIOCHEM STUO-GENERAL(10060): BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ' ACD( 10064); BIOCHEM STUO-CARBOHYDR.( 10068): BI0PHYS-MEMBRANE PHENOMENA( 10508): ENZYMES-ME THODS( 10804); PATHOLOGY-NECROSIS( 12510); METABOLISM- -GENL STUD.METAB PATHW(13002); METABOLISM-ENERGY,RESPIRATION(- 13003): DIGESTIVE SYST-PHYSI0L.BI0CHEM(14004); URINSYST/EXT SECR-GEN STUD.METH( 15501 ): ROUTES OF IMMUNIZ.INFECT,THERAP(22- 100); TOXICOL-GENL/EXP- STUOS.METHS(* 22501); NEOPLSMS/NEOPL AGNTS-CELL LINE(24005): NEOPLSMS/NEOPL AGNTS-CARCIN0GENS(* 24 - 007): PEDIATRICS(25000); TISS CULTURE-APPARAT,METHS.MED IA(325- 00) BlosystematIc Codes: MAMMAL IA-UNSPECIFI ED AND EXT INCT(85700) ; CRICETIDAE(B6310); MURI0AE(86375) 65047285 A METHOD FOR DETECTING CARCINOGENIC ORGANIC CHEMICALS USING MAMMALIAN CELLS IN CULTURE STYLES J A CENT. TOXICOL. LAB., IMP. CHEM. IND. LTD.. ALDERLEY PARK. MACCLESFIELD, CHESHIRE. ENGL.. UK. BR d CANCER 36 (5). 1977 (RECD 1978) BdCAA 558-563. Coden: Language: ENGLISH A method for testing organic chemicals for their carcinogenic potential Is described. Baby hamster kidney cells (BMK-21/C1 13) were exposed to different doses of test compound In liquid tissue culture medium containing rat liver postmItochondr1 a 1 supernatant and cofactors (S-9 mix) to aid motnhnllsm, but without serum. Survival of cnlls following exposure to the compound was assessed by cloning In liquid growth medium. 1 cans format<on was assessed by colony growth In semi-sol Id agar. The dose - response curve for survival was used to determine the LC50 (median lethal concentration] of the compound. . A dose - response curve for transformation was constructed and a 5 fold Increase In tronsformntIon frequency at the LC50 was regarded as a positive tost result. The method may also be used for testing gaseous compounds. Colls grown In monolayers and overlaid with serum-free medium and S*9 mix were exposed to vinyl chloride gas mixed with air. After exposure, the treated cells were trypslntzed, resuspended In growth medium and survival and transformation assays were performed. The methods described are Illustrated by examples taken from an evaluation study using 120 compounds and wore F^^^5) dial" "F 1 1 e 5 : BIOSIS Previews ----- . noM-iiinjt See R&S 138548 65045540 PHYSIOLOGICAL CHARACTERISTICS OF CLAOOSPORIUM-RESINAE LEVKINA L M; REBRIKOVA N L DEP. LOWER PLANTS, M.V. LOMONOSOV MOSC. STATE UNIV.. MOSCOW. USSR. MIKOL FITOPATOL Coden: MIFIB 10 (5). 1976 (RECD 1977) 374-380. Language: RUSSIAN Tests were conducted on different strains of C, reslnae, which grows on petroleum products, fuel oils, lubricants, varnishes, paints and polyvinyl chloride plastics. causing spoilage. The fungus utilized n-alkanes with more than 13 C atoms (especially C10-C25) better than hydrocarbons with a shorter chain. The number of fatty acids formed during the growth of the fungus correlated with Its biomass, and may serve as an index of the degree of utilization of a given hydrocarbon. During growth on hydrocarbons with CI4-CIC, the C, reslnae strains released tartaric and oxalic acids Into the medium. Two morphological forms of this fungus, C, reslnae f, reslnae and C. reslnae f. kvellaneum, showed differences In the utilization of different hydrocarbons. the acidification of the medium and the formation of organic acids. Descriptors: CLADOSPORIUM-RE 5 INAE-F-RES INAE CLADOSPORIUM-RE- SINAE-F-AVELLANEUM FATTY-ACID POLY VINYL CHLORIDE PETROLEUM FUEL OIL LUBRICANT VARNISH PAINT HYDRO CARBON Concept Codes: BIOCHEM STUO-GNERAL(10060): BIOCHEM STUD-LIPIDS( 10066); METABOLISM-GENL STUD,METAB PATHW(* 13002); METABOLISM-LIPIDS(* 13006); MICROBIOLOG APPARAT.METHS.MEDI A(32 - OOO); FOOD/INDUS MICRO-BIODEGRAD.DETER(* 39006); PLANT M0RPH0L.EMBRY0L,ANAT0MY(5100O); PLANT PHYSIOL-METABOLISM(*51519) BIosystemat1c Codes: DEUTEROMYCETES(15500) (c. BIOSIS 1982) (Item 629 of 858) User 3G14 25JnB3 2 194 histologic structures. These changes are different from those structural alterations occurring In spleens following extrosplenlc hemodynamic changes, such as thrombosis of the splenic veins or cirrhosis of the liver. Descriptors: HUMAN ELECTRON MICROSCOPY MACROPHAGES FIBROBLASTIC CELLS Concept Codes: MICROSCOPY-HISTOL.HISTOCHEM TECH(01056): ELECTRON MICROSCOPY(01058): CYT0L0GY/CYT0CHEM-ANIMAL(0250G); BIOCHEM METH-PROTNS.PEPTDS,AM AC(10054); BIOCHEM STUD-GENERAL- (10060): BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACD(10064); ENZYMES-METHODS( 10804); ENZYME5-PHYSI0L0GICAL STUOIES(* 10808 ) : ANATOMY/HISTOL-MICRQ.ULTRAMICRSC(* 11108); CARDIOVASC SYST-BLD VESS PATH0L( 14508); BLOOD/BODY FLOS-BLD.LYM,RES PATHC* 15006); BLOOD/BODY FLDS-LYMPHAT TISS.RES(15008); BONE.JNTS.FASC.CONN- /ADIP-PHY,BCH(* 18004); TOXICOL-GENL/EXP STUDS.METHS(*22501) Blosystemat1c Codes: HOMINIDAE(86215) 65043053 ENZYME HISTOCHEMICAL HISTOMETRICAL AND ULTRASTRUCTURAL STUDIES OF SPLEENS IN VINYL CHLORIDE DISEASE HEUSERMANN U: STUTTE H J ABT. ALLG. PAIHOL. PATHOL. ANAT.. KLIN., CHRIST.-ALBRECHTS-UNIV. KIEL. HOSPITALSTR. 42. D-2300KIEL. W. GER. VIRCHOWS ARCH A PATHOL ANAT HISTOL Coden: VAAPB 375 (4). 1977 303-3tB. Language: GERMAN By hIstometrIc, enzyme hIstochcm1ca1 and EM Investigations It was demonstrated that the pathological changes In the spleen (human) In v1ny1ch1 or Ido-dIsease are primary. Fibroblastic cells are the only specific splenic cells Involved, r1 bur-assoc I a ted reticulum cells of the red pulp and fibroblastic' ret leu Him colls In white pulp nru stimulated to produce excessive amounts or tho extracellular elements of connective tissue. especially collagen fibrils. The newly formed connective tissue caused obliteration of extracellular blood channels In the red pulp, and thus a reduction In the number of pulp-cord macrophages and scarring of the perlaterlal lymphatic sheaths. The results of this fibrosing process are char lietor I atIC quantitative changes In tho splenic DIALOG FI Ie5: BIOSIS Previews 77-83/dan BA7502:RRM2402(See fi .55) (c. BIOSIS 1982) (Item 631 of 858) User 3614 nB3 2195 R&S 138549 65043022 PERMISSIBLE LEVELS OF MIGRATION OF STABILIZERS FROM POLY VINYL CHLORIDE SHEFTEL V 0: TSAM Z S: MARTSON L V; KALINICHENKO L T ALL-UNION RES. INST. HYG. TOXICOL. PESTIC. POLYM. PLAST., KIEV. USSR. GIG SANIT (3). 1977 109-110. Coden: GISAA Language: RUSSIAN A series of experiments were conducted with mice and rats to determine the hygienic effects of migration Into the water supply of stabilizers from polyvinylchloride products, largely Pb, organotIn and Ba-Cd compounds. Rats In the 10th mo. of Pb Intoxication manifest Increased coproporphyrln content In the urine, while decapitated animals had deposits of Pb In the liver and bone tissue. Rats administered 0.005 mg/kg of lead acetate for 12 mo. manifest dystrophic changes in the liver and kidneys. Organotln stabilizers (dIocty1stannous carboxylote [DOSC], d I octy1th I otIn [DOTT], dI Isoocty1thIoglyc- olate of dlbutyltln [DIOTGDBT]) proposed for shatterproof vinyl plastic water supply components were highly cumulative In rats. with coefficients of accumulation of 1.34 (DOTT). 1.45 (DOSC) and 0.3 (DIOTGDBT). A single dose of DIOTGDBT at 1/5 LD50 on the 9th day of pregnancy Impaired the course of pregnancy and the process of embryogenesIs In rats. The permissible level of migration Into water from Pb materials can be set at 0.05 mg/1 for organotln stabilizers. Descriptors: MICE RATS LEAD CADMIUM BARIUM BASED COMPOUNDS LIVER KIDNEY BONE PREGNANCY URINE Concept Codes: 8IQCHEM STUD-GENERAL(10060); BIQCHEM 5TUD-P0RPHYRNS.BILE P1GM( 10065); MINERALS( 100G9); ANATOMY/HJS- TOL-EXPERIMENTAL! 11104); CHORDATE BODY REGNS-HEAD( 1 1304 ); MINERALS(* 13010); METABOLISM-PORPHYRI NS.BILE PIGMN( 13013); DIGESTIVE SYST-PHYSIOL.BIOCHEMf 14004); DIGESTIVE SYST - PATHOLO GY! 14006); URIN SYST/EXT SECR-PHYSL.BI0CHEM(15504); URIN 5YST/EXT SECR-PATHOLOGYt 15506); REPRODUCT SYST-PATHOLOGY( I 650- 6); BONE.UNTS.FASC,CONN/AO IP-PHY,BCH( 18004); TOXI COL'GENL/EXP STUDS.METHS(*22501): TQXI COL-ENVIRONMNTL,INDUSTR(* 22506); PUB HEALTH-ADM INISTR,STATISTICS(*37010); ENVIRON HEALTH-A IR,WATR.SL POLLN( *37015) Blosystemat1c Codes: MURIDAE(8G375) characteristics may apply to other monomers and such components of polymeric materials as plasticizers, stabilizers, dyes and other additives. Descriptors: REVIEW ANIMALS FOOD PRODUCTS OCCUPATIONAL EXPOSURE ANGIO SARCOMA MODEL POLYMER COMPOUND Concept Codes: BIOCHEM STUD-GENERAL(10060); METABOLISM-GENL STUD.METAB PATHW(* 13002); DIGESTIVE SYST-PHYSIOL.BIOCHEM(1400- 4); CARD IOVASC SYST-BLO VESS PATHOL(14508 ) ; TOXICOL-FOOO.RESI- DS.ADDIT,PRESRV(*22502); TOXICOL-ENVIRONMNTL,INDUSTR(*22506); NEOPLSMS/NE0PL AGNTS-CARCIN0GENS(24007); ENVIRON HEALTH-OCCUP- ATNL HEALTH(*37013)-. ENVIRON HE AL7H-A IR . WATR . SL POLLN( * 37015 ) Blosystematic Codes: ANIMALIA-UNSPECIFIED(33000); H0M1N1DAE- (862 15 ) 65042285 ENGINEERING CONTROL ASSESSMENT OF THE PLASTICS AND RESINS INDUSTRY CASE STUDY MANUFACTURE OF POLY VINYL CHLORIDE BY BULK POLYMERIZATION/ SCHOULTZ K S; BOCHINSKI. d H; GIDEON d A ENVIRO CONTROL INC.. ONE CENTRAL PL.. 11300 ROCKVILLE PIKE. ROCKVILLE, MD. 20852. USA. AM INO HYG ASSOC J 38 ( 12). 1977 653-661. Coden: AIHA A Language: ENGLISH As part of a control technology assessment of the plastics and resins Industry, a bulk polymerization process manufacturing polyvinyl chloride (PVC) Is surveyed. Effective control techniques for reducing workplace concentrations of vinyl chloride Include a computerized process design, an automatic air monitoring system for rapid leak detection. a novel local exhaust system, various equipment modifications to prevent leaks and a PVC stripping operation. Personal and area sampling data are evaluated to determine the effectiveness of the overall control system. The control techniques can be applied to other processes where toxic materials are used. Concept Codes: GENL BIOL-INFRMTN.DOCU.COMP APPL(00530): ECOLOGY-BIOCLIMATOL.BIOMETEOROL(07504); BIOCHEM METH-GENERAL(- 10050); BIOCHEM STUD-GENERAL(10060); BIOPHYS-BIOENGINEER1NG(- 10511); 8IOPHYS-BIOCYBERNETICS( 10515); TOXI COL -ENVIRONMNTL.I - NOUSTR(*22506); ENVIRON HEALTM-OCCUPATNL HEALTH!* 37013); ENVIRON HEALTH-AIR,WATR.SL POLLN(37015) 65042877 THE HAZARDS OF ALIMENTARY PENETRATION OF VINYL CHLORIDE INTO THE HUMAN BODY BYKIIOVSKII A V; 0YUBANKOVA E N F.F. ER1SMAN MOSC. INST. HYG.. MOSCOW. USSR. GIG SANIT (3). 1977 70-74. Coden: GISAA Language: RUSSIAN Studies ,of the dangers In utilization of polyvinylchloride products ar\i reviewed. Migration of residual vinyl chloride (VC) from containers Into food products. the Incldenco of occupational angiosarcoma linked to VC exposure. International reduct Ions of permissible concentrations of VC, the mechanisms of occupational VC disease and pathways of VC entrance Into the bodies of humans and animals are discussed. VC can be taken as a model for polymeric materials In general, and Its DIAL' Tl1e5: BIOSIS Previews 77 R&S 138550 ) (c. BIOSIS 19B2) (Item 634 of 858) User 3614 25Jan03 2 196 65042242 SANITARY HYGIENIC ASSESSMENT OF PLASTICIZED POLY VINYL CHLORIDE MATERIALS RUDENKO A A GIG SANIT (8). 1977 101-102. Coden: GISAA Language: RUSSIAN Tests were performed under modeled conditions with the highest possible temperature (40.degree. C) and simultaneous air exchange of emissions from plasticized po1yvIny1 chi or Ide In 1 type of decorative paneling and 2 types of artlflal leather. While plasticized polyvinylchloride materials were not sources of air contamination with C1-conta InIng components. higher alcohols used In plasticizers emitted complex esters In proportion to their content In the materials. In material with 35% plasticizer content. these esters were at the permissible level of 0.05 mg/m3. Descriptors: AIR CONTAMINATION Concept Codes: ECOLOGY-BIOCLIMATOL.BIOMETEOROL(07504): DIOCHEM STUD-GENERAL( I00G0); EXTERN EfE-HOT( IOC 18); TOXICOL-ENVIRONMNIL.INDUSTR(*22506): TEMPERATURE-GENL.METHS(23001): PUB HEALTH-ADMINISTR,STATISTIC- S(* 37010): ENVIRON HEALTH-AIR,WATR.SL P0LLN(* 370 15) Descriptors: MICE RATS HUMANS DOGS CARCINOGENESIS LIVER TUMORS GENETIC ERRORS VINYL CHLORIDE WORKERS Concept Codes: GENET ICS/CYTOGENET-ANIMAL(03506): GENETICS/C- YTOGENET-HUMAN(03500); MATHEMATIC BIOL/STATISTIC METH(04500): ECOLOGY-BIOCLIMATOL.BI0METEOROL(07504); BIOCHEM STUD-GENERAL(- 10060): METABOLISM-GENL STUD,METAB PATHW(*13002): NUTRITION-G- ENL.NUTR STATUS.METHS(13202); DIGESTIVE SYST-PATHOLOGY(14006); TOXICOL-GENL/EXP STUDS.METHS(*22501 ); TOXI COL-ENVIRONMNTL.IND USTRY 22506 ) ; NEOPLSMS/NEOPL AGNTS-PATH.CL INIC(*24004); ENVIRON HEALTH-OCCUPATNL HEALTHt*37013): ENVIRON HEALTH-SEWG DISP.SANITAR(37014); ENVIRON HEALTH-AIR.WATR.SL P0LLN(*37015) Blosystemat1c Codes: CANIDAE(85765); HOMINIOAE(86215): MUR I DAE(86375) 65037 120 TOXICOLOGY AND DRINKING WATER CONTAMINANTS STOKINGER H E CENT. DIS. CONTROL. NATL. INST. OCCUP. SAF. HEALTH. RQBERT A. TAFT LAR.. USPHS . CINCINNATI. 0II1Q. USA. AM WATER WORKS ASSOC J JAWWA 69 (7). 1977 399-402. Coden: Language: ENGLISH The National Cancer Institute (NCI) reported chloroform to bo carcinogenic In mice and rats when administered by mouth. The tumors occurred In highly debilitated animals, resulting from the use of a maximal tolerated chloroform dose to which significant numbers of the tost animals succumbed and the survivors ended up In an unhealthy condition. Feeding exponents conducted in another laboratory Involving chloroform In lower doses (1/6-1/B of those at the NCI) yielded no malignancies In mice. No dogs developed liver tumors after 7.5 yr ofexposure to 30 mg/kgper day of chloroform. Chloroform must be regarded as an animal carcinogen of extremely low potency. Extrapolating animal data to man for the purpose of estimating the Incidence of cancer In human populations can prove a fallacy. Biologic response to a toxic agent Is not tlio same at low and high dosages , an assumption made by dataextrapo1 ators. The body has built-in antagonists that can counteract the toxicity or forolgn substances. Including potential carcinogens. Natural and dietary sources of ant1 care 1nogons also exist. Instances arc cited where thresholds for cancer production were demonstratod In animals and man. The threshold for tumor formation In rat livers ranges between 10-50 ppm In air of vinyl chloride. The Incidence of liver tumors In vinyl chloride workers Is extremely low and may be based genutlcally on Inborn offers of mot nboI Ism. R&S 138551 in BA7G02;RRM2402(See F11e55) (c. BIOSIS 1902) (Item 63G of 858) User 3614 25Jan03 2 197 G5037109 ALKYLATION OF RNA BY VINYL CHLORIDE METABOLITES IN-VITRO AND IN-VIVO FORMATION OF 1-N-6 ETHENO ADENOSINE LAIB R J; BOLT H M INST. TOXIKOL., UNIV. .'WILHELMSTR. 56. D-7400 TUEBINGEN 1, W. GER. TOXICOLOGY B (2). 1977 185-196. Coden: TXCYA Language: ENGLISH Rat liver mtcrosomes were Incubated with NADPH, 1.2-[ 14C]v1ny1 chloride and poly(A). The latter was relsolated from the Incubations and hydrolyzed. .The radioactivity, originating from [14C]v!nyl chloride, which was Irreversibly attached to the poly(A) was confined to 1-N6-etheno-adenostne (3,beta.-r1 bofuranosy1 - 1m I dazo[2, 1 . I ]pur Ine ) . When rats were exposed to 1.2-[14C]v1ny1 chloride, part of the radioactivity was Incorporated Into RNA of liver. This radioactive labeling exhibited a 1st maximum, 14 h, and a 2nd maximum, 72 h after ending the exposure. Analysis of hydrolysate of 1Iver RNA showed that all natural nucleosides of RNA were labeled. Besides, small amounts of radioactivity could be detected which were confined to 1-N6-etheno-adenos1ne. The experiments support the theory that vinyl chloride metabolites react with adenosine moieties of nucleic acid under formation of 1-N6-etheno-adenosIne. Measurement of Incorporation of radioactivity Into nucleic acids after exposure of animals to radioactive vinyl chloride Is not applicable as a moans of determining the alkylating potency of vinyl chloride metabolites towards nucleic acids In vivo. Descriptors: RAT LIVER Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(0250G): RADIATION BIOL-RADTN,ISOTOP TECH106504); 8 IOCHEM STUD-GENERAL( 10060): BJOCHEM STUD-NUCL ACD,PURNS.PYRM(I0062); BIOPHYS-MEMBRANE PHENOMENAt 10508 ) : METABOL1SM-GENL STUD.ME TAB PATHW( 1 3002): METABOLISM-NUCL ACD.PUR I NS.PYRIM(* 13014); DIGESTIVE SYST-PHYS- 10L,BI0CIIEM(* 14004); TOXICOL -GENL/EXP STUDS,METHS(*22501); TISS CULTURE-APPARAT,METHS.MEDIA(32S00); IN VITRO STUOS-CELLU- LR.SUBCELLf 32600) B losys teinat 1c Codes: MUR I OAE ( 86375 ) 65037044 PARTICLE SIZE EFFECTS IN THE DETERMINATION OF RESPIRABLE ALPHA QUARTZ BY X-RAY DIFFRACTION rOMONOS J W: IIENSLEE W W: GUERRA R E DOW CI1EM. CO.. ANAL. LAB., MIDLAND. MICH. 48G40, USA. ANAL CHEM 49 (14). 1977 2196-2203. Codon: ANCHA Language: ENGLISH Thin layers (.Itorslm. 200 .mu.g/cm2) of .a 1pha.-guartz particles un Ag and polyfvlnyl chtorldo) membranes are shown to exhibit preferred or I on ta t1 on enhancIng the ( 10.hIvIn. 11) diffraction lino (3.34 ,ANG.) for particles In the norma I 1y accepted size range for X-ray diffraction standards (< 15 .mu.m). Respirable silica (< 5 .rnu.m) analyses performed by X-ray diffraction using .a 1pha,-quartz standards whose particle size distribution does not match the field sample distribution exhibit orrors up to 3007. of the amount of .aIpha. -quartz present. Sample connedtratI on In lho personal samplers Is shown to be an effective means of Increasing sensitivity and establishing a nondestructive analysis. but particle size determination of field samples In necessary to aid selection of an approprIately sized standard. Observed threshold sensitivity for .a 1pha.-quartz at the 957. confidence level (2.sigma. above background) Is 11 .mu.g/cm2. [Recognition of the health hazard due to prolonged exposure to airborne respirable silica has prompted the development of many analytical methods for silica based on various techn1ques.] Descriptors: AIRBORNE PARTICLE EXPOSURE HEALTH HAZARD Concept Codes: MATHEMATIC BIOL/STATISTIC METH(04500): RADIATION BIOL-RADTN.ISOTOP TECH{*06504); ECOLOGY-BIOCL1MATOL- .BIOMETE0R0L(O75O4): BI0CHEM METH-M1NERALS(*10059); MINERALS(- 10069): 81OPHYS-GENERAL BIOPHYS TECH(* 10504); RESPIRATORY SYST-GENL STUO,METHS( 16001 ); TOXICOL-GENL/EXP SIUDS.METHS(*22- 501): TOXICOL-ENVIRONMNT L.INDUSTRf 22506); ENVIRON HEALTH-AIR,- WATR.SL POLLN(37015) 65036553 TRACE DETERMINATION OF VINYL CHLORIDE IN WATER BY DIRECT AQUEOUS INJECTION GAS CHROMATOGRAPHY MASS SPECTROMETRY FUJI I T DIV. CIIEM. PI IYS. , NATL. INST. ENVIRON. RES.. YATABE . TSUKUBA. IKARABA 300-21. JPN. ANAL CHEM 49 (13). 1977 1985-1987. Coden: ANCHA Language: ENGLISH Described Is a rapid, precise and specific method for the analysis of vinyl chloride (VC) at the sub-ppb level In water Samples. The method Involves the use of mass fragmentography of the gap chromatography-mass spectrometry by simultaneously recording m/e [mnss:charge ratio] 62 and G4 after direct aqueous Injection of a large sample (1000 .mu.1) on the precolumn (diglycerol as a liquid phase) with no concentratI on or extraction required. Several tap waters In Tokyo [Japan] areas were tested, and VC was not found to be present. Descriptors: TOKYO JAPAN Concept Codes: ECOLOGY-OCEANOGRAPHY.LIMNOLOGY(*075 10 ) : ECOLOGY-WATR RESRCH.FISHERY BI0L(07517); B1OCHEM METH-GENERAL- (*10050); BIOCHEM STUD-GENERAL(10060): BI0PHYS-GENERAL BIOPHYS T ECH( 10504); MOVEMENT(12 100): TOXI COL -ENVIRONMNTL.IN0USTR(*22- 506): ENVIRON HEALTH-A 1R.WATR,SL PQLLN(*37015) ft DIAL FI 1e5: BIOSIS Previews 77-03/Jan BA7502:RRM2402(See 6503567 B ADSORPTION OF MICROORGANISMS ON POLY VINYL CHLORIDE PLASTIC MATERIALS GORCHAK G I A.N. MARZEEV KIEV RES. INST. GEN. COMMUNAL HYG.. KIEV, USSR. GIG SANIT (5). 1977 110-111. Coden: GI5AA Language: RUSSIAN A series of tests of the adsorption of Bacillus anthracls on polyvinylchloride (PVC) plates Indicated that the Interaction of the microorganisms and polymers Is varied and determined by the surface properties of the material and the bacterial membranes. Bacilli adsorption on polymer materials Is fairly strong. but may be reversed by the action of enzymes such as hya1uron1dase, resulting In spontaneous desorption, interruption of the molecular surface link between the bacterial membranes and the material, destructive processes In the polymer and chemical and structural changes In the bacter 1 a 1 cel 1s. Descriptors: BAG ILLUS-ANTHRACIS HYALURONIDASE Concept Codes: BIOCHEM STUD-GENERAL!10060): BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACD(10064); BIOPHYS-GENERAL STUDIES!* 10502); BIOPHYS-MOLECUL PROP.MACROMQLEC!* 10506); BIOPHYS-MEMBRANE PHENOMENA(10508): ENZYMES-METHODS( 10004); BACTERIA-MORPHOLOGY,CYTOLOGY!* 30500); BACTERIA-PHYSIOLOGY.BIOCHEMISTRY!*31000): MICROBIOLOG APPARAT- .METHS.MEDIA(32000): FOOO/INOUS MrCRO-BIODEGRAO.DETER(39006) Blosystemat1c Codes: EUBACTERIALES(07200) (c. BIQSIS 1982) (Item 639 of 858) User 3614 25Jan83 2 198 APPARATUS(OIOIO); ECOLOGY-ANIMAL(*07508); ECOLOGY-LIMNOLOGY(O- 7514): ECOLOGY-WATR RESRCH.FISHERY BI0L(07517): ECOLOGY - TERRE - STRIAL WILDLIFE MGMT( *07510); BIOCHEM STUD-GENERAL( 10000 ) ; CHORDATE BODY REGNS-EXTREMITIES( 1 1 3 18 ) ; REPRODUCE SYST-GENL STUDS.METHS(* 16501); CHORDATE TAXONOMY-AVES(*6251B ) B losystemat1c Codes: ANSERI FORMES(85504) / 65032801 COLOR MARKING OF GOOSANDERS MERGUS-MERGANSER AT THE DANISH BREEDING GROUNDS HANSEN S G ZOOL. MUS., UNIVERSITETSPARKEN 15, 2100 KOBENItAVN. DEN, DAN 0RN1TH0L FOREN TIOSSKR DOF T A 71 (1-2). 1977 65-69. Coden: Language: DANISH Marking of 3 breeding female goosanders by placing color rings on the legs was made for the 1st time In Denmark In the summer of 1976. Previously used marking methods are discussed. By marking the birds with colored leg rings made of colored slips of semi-rigid Darvlc plastic It was possible to recognize the ring In daylight and Identify the perching bird at a distance up to 400 m using a telescope (25.times,). The minimum distance one 13 able to approach the bird at Danish breeding grounds Is 300-400 m. The colors used were yellow, blue, light green and red. The 1st 3 are more appropriate since red Is difficult to recognize on the bird's red leg. The rings did not bother the bird. After ringing the females returned to the nest and completed breeding. The method may bo applicable only In areas with a low population density, because the number of combinations of color and right/left log ts limited. Where the population density is higher, wing tags have been used. Descriptors: DARVIC PLASTIC POLY VINYL CHLORIDE WING LEG RINGS TELESCOPE Concept Coder.: GENERAL FIELD ME Tl IDDS ( O 10011 ) ; GENERAL TIEI.O DIAL/ T I le5: R10SIS Pi-evti B&S 138552 12*102 ( See FiTe55 (c. BIOSIS 1982) (Item G41 of 858) User 3614 25Jan83 2 199 G5030GB4 CHEMICAL MODIFICATION OF ACUTE HEPATO TOXICITY OF VINYL CHLORIDE MONOMER IN RATS JAEGER R J; MURPHY S D; REYNOLDS E S: SZABO S: MOSLEN M T TOXICOL. UNIT, DEP. PHYSIOL., KRESGE CENT. ENVIRON. HEALTH HARV. SCH. PUBLIC HEALTH. BOSTON. MASS. 02115, USA. TOXICOL APPL PHARMACOL TXAPA 41 (3). 1977 597-608. Coden: Language: ENGLISH Six hour inhalation exposure of male rats to vinyl chloride monomer (VCM) was hepatotoxlc as measured by elevated serum a 1 anine-.a 1pha.-ketog 1utarate transaminase (AKT) when the rats were pretreated with either sodium phcnobarb 1 ta 1 to. t'/. In the drinking water, 7 days) or Aroclor 1254 (pretreatment doses given by gavage; 100. 200 or 300 .mu.mol/kg per day for 3 days). Following Aroclor 1254 pretreatment and VCM exposure, serum AKT elevation was proportional to Aroclor 1254 dose as well as VCM concentration (range 12.500-50,000 ppm). In phenobarbttal-pretreated rats, fasting, but not diethyl maleate, significantly potentiated VCM Injury; SKF-525A [2-dIethy1 am Inoethy 1-2.2-dIpheny1va1 erate hydrochloride) (75 mg/kg, l.p.) given 30 min prior to exposure prevented liver injury produced by VCM. Both Aroclor 1254 and phenobarbito 1 pretreatment increased in vitro liver hexobarbltal oxidase activity In unexposed animals. Exposure to VCM caused hexobarbltal oxidase activity to decrease In livers from both nonpretreated and pretroated rats. The decreases In activity did not correlate with injury as measured by serum AKT. Ethyl alcohol (3.33 ml/kg) given by gavage 30 min prior to VCM exposure In phenobarbIta 1-pretreated rats was associated with a nonsignificant serum AKT increase when compared to controls not given ethanol. A larger dose of ethanol (5 ml/kg, orally) given to Aroclor 1254-pretreated rats prior to VCM did not Increase the serum AKT elevation compared to controls. Four doses of ethanol (5 ml/kg, orally) given to phenobarbttal-pretreated rats at 48, 42, 24 and 16 h before VCM exposure did not potentiate the Increase in serum AKT caused by VCM. Disulfiram (200 mg/kg. l.p., or 1000 mg/kg, orally) given prior to VCM exposure In Aroc1 or-pretreated rats produced a significant potentiation of VCM toxicity. The data suggest ' that VCM is activated to a toxic intermlate and this activation Is inducible and, while ethyl alcohol per se does not appear to play a primary or modifying role In acute VCM hepatotox1c1ty. inhibitors of ethanol metabolism modify the toxicity of VCM. Descriptors: SERUM ALANINE ALPHA KETO GlUTARATE TRANS AM1NASE AROCLOR 1254 DISULFIRAM METAB-DRUGS SODIUM PHENO BARB 11AL SKF-525-A Concept .Codes: CLIN BIOCHEM-GENL STUD IES( 10006); BIOCHEM 5TUD-GENERAH 10060) : BIOCHEM STUD-NUCL ACO . PIJHNS . PYRM( 10062 ) ; BIOCHEM STUO-PROIEINS,PEPTIDES.AMINO AC0(10064); ENZYMES-PHYSI0L0GICAL STUDIES!* 10008); CHORDATE BODY REGNS-ABOOMEN( 1 1 3 1 4 ) ; ME IABOLISM-GENL SIUO.METAB PAIHW(* I 3002); D1GES1IVE SYST-GENL STUDS.METHSt 14001): DIGESTIVE SYST-PHYSIOL,B1OCHEM(* 14004 ); BLDUD/BODY FL0S-8L00D.LYMPH STUD( 15002); OENIAl./ORAL BIOL-GENL SrUD.MCTHSf 19001 ): PHARMACOL-DRUG ME TAB,ME IAU STI MU(22003>; ROUIES OF JMMUNIZ.INFECT.THE RAP(22100); '. TOXI COL-GENL/EXP STUDS.MC TMS(*22501 ); TOX 1 COL - ANT I DO IES.PREVCNI I VC(2 2 505); I ISS CULTURE*APPARAT,METHS.MEDIA(32500): IN VITRO STUDS-CELLULR.SUBCE LL(32600) BiosystematIc Codes: MUR I DAE(86375) DIALC 11e5: BIOSIS Previews 77-83/j R&S 138553 5) (c. BIOSIS 1982) (Item 642 of 858) User 3614 25Jan83 2200 65030645 SCINTIGRAPHY OF LIVER AND SPLEEN IN VINYL CHLORIDE WORKERS BIERSACK H J: LUIS T S JR; LANGE C E; THELEN M; VELTMAN G; WINKLER C INST. KLIN. EXP. NUKLEARMED.. UNI VERS ITAETSKLIN. . BONN-VENUSBERG. W. GER, 5300 ACTA HEPATO-GASTROENTEROL AHGSB 24 (5). 1977 357-361. Coden; Language: ENGLISH Liver fibrosis and angiosarcoma of the liver were established as occupation diseases In workers of PVC [polyvinylchloride] producing and processing plants. For this reason careful medical supervision of this group of workers Is necessary. The fact that usual laboratory tests of liver function are not suitable for an early detection of VC-Induced lesions, a sensitive screening test method seemed highly desirable. Because fibrosis and angiosarcoma of the liver originate from the RES. respective changes could possibly be detected In anearly stage with the help of radioactive colloids. In 152 VC-exposed workers of whom 124 were employed In the PVC-produc11 on and 28 In VC-process Ing plants, liver and spleen Imaging was performed using 99mTc-sulfur colloid and 197Hg-BMHP. In 101 (= 81%) of the 124 workers of the PVC-productIon plant and In 18 (' 64%) workers of PVC-process 1ng factories, pathological liver and spleen scintigrams were found. The most frequent pathological change In the sc'lnt Igraphlc Image was an Increase In splenic colloid accumulation, when compared with the liver uptake. Three angiosarcomas of the liver were detected through circumscribed defects of colloid accumulation. Sequential liver scintigraphy was done In 15 cases. In 7 patients with esophageal varices, considerable decrease In portal venous blood flow was demonstrated. Sc 1ntI graph 1ca11y detectable changes are sensitive Indicators of VC-Induced lesions of the liver IncI lid Ing liver fibrosis, portal hypertension and ang1osarcoma, Descriptors; FIBROSIS ANG10 SARCOMA PORTAL HYPERTENSION Concept Codes: SOCIAL BIOL/HUMAN ECOLOGY(05500): RADIATION BIOL-RADTN. ISOTOP TECH(06504); BIOCHEM STUD - GENERAL ( IOOGO); PATHOLOGY-DIAGNOSTIC 12504 ); PATHOLOGY- INFLAMMATN. INFLAM DIS(- 12508); DIGESTIVE SYS1-GENL STUOS.METHS(14001); DIGESTIVE SYST-PATH0L0GY(* 14006); CARDIOVASC SYST-BLD VESS PATHOL( 14508 ) ; BLOOD/BODY F LDS-GENL STUDS,METHS(15001); BLOOD/BODY FLDS-BLD.LYM.RES PATH(* 15006); BLOOD/BODY FLDS - LYMPIIAT TISS.RES( 15008); BONE,JNTS.FASC.CONN/AO IP-PATHOL( 18006); TOX ICOL -ENVIRONMNTL, INOUSTRt *22506); NEOPLSMS/NEOPL AGN TS-PATH.C- LINIC(24004 ) ; NEOPLSMS/NEOPL AGNTS-CARC I NOGENS(*24007); ENVIRON HEALTH-OCCUPATNL HEALTH(37013); ENVIRON HEALTH-A IR,W- ATR.SL POLLN(*37015) nlosystomnt 1c Codes; HOMINI DAE(862 15) J FOOD SCI 42 (6). 1977 1517-1521. Language: ENGLISH Coden: JFDSA Wholesale legs and loins were vacuum packaged. chilled with CQ2 pellets, or wrapped with polyvinyl chloride (PVC) film and transported-stored (0,degree. C) for 7 or 14 days; Intact carcasses were unprotected or wrapped In PVC ' film and transported-stored for 7 or 14 days. Product'was evaluated following transport-storage. during retail display and as cooked cuts. Vacuum packaged loins sustained less (P < 0.05) surface discoloration and had higher scores for muscle color and overall appearance than did .loins chilled with C02 or loins wrapped In PVC film. Vacuum packaged legs had higher (P < 0.05) scores for appearance of subcutaneous fat and overall appearance than did legs chilled with C02 or legs wrapped In PVC film. Carcasses wrapped In PVC film had higher (P < 0.05) scores for appearance of subcutaneous fat and sustained less (P < 0.05) shrinkage during storage than did unprotected carcasses. Unprotected carcasses had a lower Incidence of off-odor. Carcasses or primal cuts which were transported-stored and placed In the retail case within 7 days were effectively protected from shrinkage and deterioration by wrapping with PVC film. Vacuum packaging was the only suitable means for protecting lamb primal cuts during transport-storage Interval's of 14 days. Descriptors: LEG LOIN VACUUM CARBON DI OXIDE CHILLING POLY VINYL CHLORIDE FILM MUSCLE COLOR SHRINKAGE DETERIORATION Concept Codes: MATHEMATIC BIOL/STATISTIC MET1K04500): BI0CHEM-GASES(10012); BIOCHEM STUD-GENERAL(10060); EXTERN EFF-TEMPERATURE( 10614): EXTERN EFF-COLD(10616); CHORDATE BODY REGNS- LUMBAR( 11311); CHORDATE BODY REGNS-EXTREMITIES( 1 1 3 1 8 ) ; TODD TECH-MEAT.MEAT BY-PRODUCTS(* 13516); FOOD TECH-EVALNS PHYS.CHEM PR0PS(* 13530); FOOD TECH-PREP.PROCESSNG.STORAGE(*13532); MUSCLE SYST-PHYS1OL.BI0CHEM(* 17504); BONE.JNTS.FASC,CON N/AD IP-GENL(18001); TEMPERATURE-GENL,METF1S(23001); TEMPERATUR E-CRYOBIOLOGY ( 23004 ) BIosystematic Codes: BOVIDAE(857 15 ) G502G678 PACKAGING SYSTEMS FOR TRANSPORT AND STORAGE OT LAMB TATUM J D; SMITH G C; CARPENTER Z L MEATS AND MEAT' CHEM. SECT., DEP. ANIM. SCI.. TEX. AGRIC. FXP. SIN,. 1 F X . ASM UN IV. . COLICGC STATION, IIIX. 77043, USA. DIALfl^FileS: BIOSIS Previews 77-03/Jan BA751 f R&S 1385 (c. BIOSIS 1982) (Item 644 of 858) User 3614 25Jan83 2201 65026607 MICROBIAL CORROSION OF PLASTICIZED POLY VINYL CHLORIDE USED FOR METAL PROTECTION DONIN M A; MANDZHGALADZE S N; DASHNIANI T S; KEMKHADZE V S INST. METALL.. ACAD. SCI. GEORGIAN SSR. TBILISI. USSR. SOOBSHCH AKAD NAUK GRUZ SSR 06 (3). 1977 665-660. coden: SAKNA Language: RUSSIAN The Influence of several fungicides on the resistance of plasticized polyvinylchloride to microbial [fungal) corrosion Is considered. The proposed combination of sallcyl anilide and sodium tetraborate was effective, evidently due to the phenomenon of synergism. In contrast to widely applied toxic Sn-organlc compounds and those of As and of Hg. Descriptors: FUNGI ARSENIC MERCURY TIN ORGANIC COMPOUNDS SALICYL ANILIDE SODIUM TETRA BORATE FUNGICIDES Concept Codes: BIOCHEM STUD-GENERAL(10060): MINERALS(10069); METABOLISM-GENL STUD.ME T AB PATHW( 13002); MINERALS( 13010); PHARMACOL-DRUG MET AB.MET AB ST I MU(22003): MICROBIOLOG APPARAT,METHS.MEDIAf 32000); FOOD/INDUSMICRO-BIODEGRAD.OETER(- 39006); PLANT PHYSIOL-GROWTH SUBSTANCES(*51514): PLANT PHYSIOL-METABOLISM(5 15 19) ; PEST CONTRL GENL/PEST ICS/HERBICS(54600) Blosystemattc Codes: FUNGI-UNSPECIFIED( 15000); ABSTRACTS OF MYCOLOGY(95000) 65025 148 AUTOMATED ANALYZER FOR THE DETERMINATION OF POTASSIUM AND SODIUM IN WHOLE BLOOD DURST R A ANAL. CHEM. DIV., NATL. BUR. STAND.. WASHINGTON. D.C. 20234, USA . CLIN CHIM ACTA 80 (1). 1977 225-234. Coden: CCATA Language: ENGLISH An automated analyzer for the measurement of K and Na In whole blood was developed and evaluated. The sensors used In this Instrument are the Na glass and K (vallnomycln In polyvinyl chloride) membrane electrodes. The features of this system Include automatic 2 point calibration at fixed Intervals or on command. automatic rinsing between mensuremonts, digital display and printout of tho. emf [electromotive force) data, and a sample volume requirement of 0.5 ml. In addition to tho evaluation of tho response of the system to aqueous and whole blood samples, a study was mado of the correlation of data obtained on plasma samples with a flame photometer and the electrometric K/Na analyzer. For both e1ectrodes_the correlation was very good (r 0.998 for K and r = 0.991 for Na). No anomalous effects were observed with blood samples from normal volunteers, howover. no studies wero performed with samples taken from patients which might show dI sea so - Induced changes In lon-blndlng properties or Interferences from medications. From this study, It appears that the Na and K electrodes are able to meet sensory requirements for a clinical blood-electrolyte Instrument. Since an analyzer based on 1 on-se1ect1ve electrode technology can determine No and K In whole blood, such an automatic Instrument could be used outside .of the central clinical laboratory for stat analyses. While the feasibility of this type of Instrument has been demonstrated. much more work Is required to establish Its performance charocterIstIcs for clinical analysis. Descriptors: HUMAN VALINOMYCIN POLY VINYL CHLORIDE MEMBRANE ELECTRODE SODIUM GLASS Concept Codes: MATHEMATIC BIOL/STATISTIC METH(04500): CLIN BIOCHEM-GENL STUD IES(*10006): BIOCHEM METH-MINERALS(* 10059); BIOCHEM STUD-PROTEINS.PEPTIDES.AMINO ACD( 10064); BIOPHYS-GENE - RAL BIOPHYS TECH(* 10504); BIOPHYS-BIOENGINEERING(10511): BL00D/800Y FLDS-BLOOD.LYMPH STUD(*15002); PHARMACOL-GENERAL STUDIES(22002); CHEMOTHERAPY-GEN STUD.METH,METAB(3B502) BlosystematIc Codes: HOMINIOAE(86215) 65024003 ANGIO SARCOMA OF THE LIVER AN EPIDEMIOLOGIC SURVEY BRAOY <J; LIBERATORE F; HARPER P; GREENWALD P; BURNETT W; DAVIES d N P: BISHOP M; POLAN A; VIANNA N BUR. OCCUP. HEALTH CHRON. DIS. RES.. N.Y. STATE DEP. HEALTH. TOWER BUILD.. EMPIRESTATE PL.. ALBANY. N.Y. 12237. USA. J NATL CANCER INST 59 (5). 1977 1383-1386. Coden: JNCIA Language: ENGLISH Diagnosed from 1970-1975, the annual Incidence rate for angiosarcoma of the liver among residents of New York State [USA] (excluding New York City) was 0.25/m 1 11 I on. A case-control study Indicated that direct exposure to As vinyl chloride (VC) and thorium dioxide was a significantly Important factor In the etiology of this disorder (P < 0.02). Direct exposure to these chemicals could not be demonstrated for 19 (73*/.) of the 26 study patients. The fact that 5 of these patients lived nearer to VC fabrication or po1ymer1za11 on plants, than did their matched controls lent some support to the hypothesis that Indirect modes of exposure. not specifically related to occupation. might be Important In the etiology of this disorder. DescrIptors: NEW-YORK STATE USA HUMAN ARSENIC VINYL CHLORIDE THORIUM DI OXIDE INDIRECT EXPOSURE Concept Codes: MATHEMATIC BIOL/STATISTIC METII(04500); SOCIAL BIOL/HUMAN ECOLOGY(05500); BIOCHEM STUD-GENERAL(10060): MINERALS*10069); DIGESTIVE 5YST-PATHOLOGY(14006): TOXICOL-EN- VIRONMNTL.INDUSTR(*22506); NEOPLSMS/NEOPL AC.NTS-CARCINOGENS(- 24007); PUB HEALTH-ADMINISTR.STATIST1CS(*37010); ENVIRON HEALTH-OCCUPATNL HEALTH(37013); ENVIRON HEALTH-A IR.WA1R.SL POLLN(37015): EPI OEM IOL-ORGANIC 0 IS.NEOPLASMS(*37054) Blosystemat1c Codes: HOMINIDAE(86215) DIAL F I 1 e 5 : BIOSIS Previews 77-83/Jan BA7502:RRM2402 138555 1982) (Item 647 of 858) User 3614 25Jan83 2202 650181 15 MORTALITY AMONG EMPLOYEES OF POLY VINYL CHLORIDE FABRICATORS CHIAZZE L OR; NICHOLS W E; WONG 0 OIV. BIOSTATIST. EPIDEMIOL.. DEP. COMMUNITY MED. INT. HEALTH. GEORGETOWN UNIV. SCH. MED.. WASHINGTON. D.C. 20007. USA. J OCCUR MED 19 (9). 1977 623-628. Language: ENGLISH Coden: JOCMA A cross-sectional mortality study of -1341 deaths occurring among current and former employees of 17 PVC [polyvinyl chloride] fabricators during 1964-1973 Is presented. The objectives were to Identify any angiosarcoma deaths among the employees of these fabricators and to examine distribution of deaths by cau se. No angiosarcoma deaths were found among the Study group. Sex - race-cause-spec 1f lc Proport I onate Mortality Ratios (PMR) were computed. using the corresponding USA mor ta1 1ty as the standard. Among white employees. there appeared to be an excess In total cancer mortality, part 1cu1ar 1 y that of the digestive system. Observed deaths apparent 1y ex ceedod those expected In cancers of the breast and urinary o rgans among white females. Deficit mortality was observed In c Irrhosls of liver among male and female white empIoyees. Descr1ptors : DIGESTIVE BREAST URINARY ORGANS ANGIO SARCOMA RACE SEX DIFF ERENCES Concept Codes: GENET ICS/CYTOGENET-SEX DIFFERENC(03510): PHYSICAL ANTHROPOLOGY/ETHNOBI0L(05000); SOCIAL BIOL/HUMAN ECOLOGY(05500); PATHOLOGY-DIAGNOSTIC(* 12504); PATHULOGY-NECRO- SIS(12510); DIGESTIVE SYST-PATHOLOGY(14006); CARDIOVASC SYST-HEART PATHOLOGY( 14506); URIN SYST/EXT SECR-PATHOLOGY( 155 - 06): REPRODUCT SYST - PATHOLOGY(16506); BONE.JNTS.FASC.CONN/ADI - P-PATHOL( 18006); TOXICOL-ENVIRONMNTL.INDU5TR(* 2250G); NEOPLSM- S/NEOPL AGNT S-PATH,CLINIC(* 24004 ); NEOPLSMS/NEOPL AGNT S-CARC I - NOGENS('24007 ) ; PUB HEALTH-ADMINISTR.STATISTICS(* 37010): ENVIRON HEALTH-OCCUPATNL HEALTI1 (* 37013); ENVIRON HEALTH-AIR,W- ATR.SL POLLNI*37015) CONTROL(*52518); PHYTOPATHOL-DISEASE CONTROL(54516 ) ; CONTRL GENL/PEST ICS/HERB ICS(*54600) 0losystomntlc Codes: ABSTRACTS OF MYCOLOGY(95000) PEST 65016497 CONTROLLED RELEASE PESTICIDES PART 3 HERBICIDAL SYNTHETIC POLYMER NARUSE H; MAEKAWA K LAB. PESTIC. CHEM.. FAC. AGRIC.. KYUSHU UNIV.. 46-02 FUKUOKA 812, JPN. d FAC AGRIC KYUSHU UNIV 21 (4). 1977 167-172. Coden: JFAKA Language: ENGLISH Copo1y(S-vIny1 I sothlourea-v1ny1ene-v1ny1 thiocyanate) was prepared from poly(v1nyl chloride) with thiourea as an attempt to develop contro11ed-re 1 ease herbicides. The copolymer was decomposed In an aqueous alkaline solution to give thiocyanate and other compounds. The copolymer was also decomposed by acid releasing low molecular compounds. The copolymer was not effective for germination but Inhibited the growth of seedlings of barnyard grass [Panlcum crus-gal 11 L.) on the treated `soil for 28 days. The copolymer treated with acid or base was more effective on the germination and the growth of the plant. Descriptors: PANICUM-CRUS-GALLI BARNYARD GRASS CO POLY-S VINYL ISO THIO UREA VINYLENE VINYL THIO CYANATE Concept Codes; BIOCHEM METH-GENERAL(*10050): BIOCHEM STUD-GENERAL(* 10060); BIOPHYS-MOLECUL PROP.MACR0M0LEC(* 10506); TOXICOL-GENL/EXP STUDS,METHS(22501); AGRONOMY-WEEDS AND WEED CONTROL!*52518); SOIL SCI-GENL STUDS,METHS(52801): PEST CONTRL GENL/PESTICS/HERBICS(*54600) Blosystematlc Codes; GRAMINEAE(25305) 6501G498 CONTROLLED RELEASE PESTICIDES PART 4 SYNTHESIS AND DECOMPOSITION OF POLY-S VINYLALKYL DI THIO CARBAMATE NARUSE H; MAEKAWA K LAB. PESTIC. CtlEM.. FAC. AGRIC.. KYUSHU UNIV. 46-02. FUKUOKA 812, JPN. <J FAC AGRIC KYUSHU UNIV UFAKA 21 (4 ). 1977 173- 180. Coden; Language; ENGLISH Po1y(S-v1ny1 a 1ky1d1thlocarbamate)s were prepared from poly(v1ny1 chloride) and sodium a 1ky1dIth1ocarbnmates In dI mothy1formaln I do. These derivatives were decomposed by exposure to 1Ight or by acid or base treatment to give S. S-contalnlng compounds and others. The polymers showed herb tel da I and fungicidal activities. Descriptors; HERBICIDE FUNGICIDE Concept Codes: BIOCHEM METH-GCNERAL(10050): BIOCHEM STUD - GENERAL(* 10060); BIOPHYS-MOLECUL PROP.MACIU1M0LECI ' 10506); TOXICOL-GENL/EXP S1UDS.METl IS(2250 I ); AGRONOMY-WLEOS AND WCEO R&S 138556 01 Flle5: BIOSIS Previews 77-B3/dan BA7502:RRM2402(See re55 in) 650 of B5B) User 3614 25Jan83 2203 65012207 PRESENT DAY SITUATION OF THE MIGRATION OF COMPONENTS OF PACKAGING MATERIALS INTO FOODS AND THE CONTROL OF THIS PROBLEM BY ANALYTICAL MEASURES ROBINSON L INST. LEBENSM1TTELTECHN0L. VERPACK.. MUENCHEN. W. GER. TECH. UNIV. MUENCH., LEBENSM-WISS TECHNOL Language: GERMAN 10 (1). 1977 51-56. Coden: LBWTA Protection of the public against packaging components that may migrate Into packaged foodstuffs depends on analytical controls which present difficulties that have not been completely solved. An American standard. ADI (acceptable dally Intake) or PADI (packaging AOI) with an Immutable global migration limit of 60 ppm Is not considered sufficiently flexible as there could be higher limits for Inoffensive migration products, while for highly toxic chemicals the limit should be lower. Also the available methods. such as gas chromatogrnphy, are costly. Chemicals that might migrate from packaging materials could Include vinyl chloride or acetonitrile, polystyrol and ABS polymers. Absorption of such contaminants Is especially likely to occur In fatty foods, and suggestions are given for testing packaging materials with substitute fats such as coconut, sunflower or olive oil. or a synthetic fat HB 307, which contains triglycerides of fatty acids with medium chain length. Descriptors: COCONUT SUNFLOWER OLIVE OIL SYNTHETIC FAT HB-307 VINYL CHLORIDE ACETONITRILE POLY STYROL ABS POLYMERS Concept Codes: BIOCHEM STUD-GENERAL(10060); BIOCHEM STUD-LIPIDS(10066); BIOPHYS-GENERAL BIOPHYS TECH(10504); M0VEMfNT( 12lOO); FOOD TECH-FATS.01LS(* 13514); FOOD TECH-EVALNS PHYS.CHEM PR0PS(* 13530) ; FOOD TECH-SYNTH.SUPPL,ENRICH FDS{ - 13534 ) : TOXICOL-FOOD.RESIDS.ADO IT,PRESRV(22 502); PLANT PHYS10L-CHEM CONSTITUENTS(51522); AGRONOMY-OIL CROPS(525 I 4); HORTICULT-TROP FRUIT.NUT.PLANTAT(53004) BIosystemat1c Codes: OLEACEAE(26475 ) PALMAE(25300); COMPOS 1TAE(25B40): 65012206 THE CONTENT OF VINYL CHLORIDE MONOMER IN FOODS PACKED IN POLY VINYL CHLORIDE EHTESHAM-UD DIN A F M; NORDBO E; UNDERDAL B DEP. F000 HYG., VET. COLL. NORW.. OSLO. NORW. LEBENSM-WISS TECHNOL language: ENGLISH 10 (1). 1977 33-35. Codon: LBWTA The content of v1ny1ch1 or Ide monomer (VCM) In different foods on tho Norwegian market was Investigated. Samples of button, margor1ne. vinegar, (fruit) Julce3, salad and mustard were analyzed using the Hoad Space gas chromatographic technique. Tho VCM content varied considerably and wan highest In Imported vinegar. In all samples of Norwegian origin. tho VCM concentratIons were well below the Swedish recommended maximum tolerance of 0.05 mg/kg. It was shown. In a model experiment. that the migration of VCM Into the sample Increased with Increasing acid concentration In the sample. Descriptors: NORWAY BUTTER MARGARINE VINEGAR FRUIT JUICES SALAD MUSTARD Concept Codes : BIOCHEM STUD-GENERAL{10060) ; FOOD TECH-GENL STUDS.METHSf* 13502); FOOD TECH-FRUtTS.NUTS.VEGETABLES(* 13504) ; FOOD TECH-MALTS.BREWS,FERMENTATN(* 13512) ; FOOD TECH-DAIRY PR0DUCTS(* 135 18); FOOD TECH-EVALNS PHYS.CHEM PROPS(*13530): TOXICOL-FOOD.RESIDS.ADDIT.PRESRVl*22502); HORTI CULT-VEGETABLES(53008) B 1 osys tema 11c Codes: ANGI0SPERMAE-UNSPECIFIED(25200); CRUCIFERAE(25880) 65007129 A NEW ANTI THROMBOGENIC HEPARINIZED POLYMER MIYAMA H; HARUMIYA N; MORI Y; TANZAWA H BASIC RES. LAB., TORAY IND. INC., 1111 TEBIRO, KAMAKURA. JPN. J BIOMED MATER RES 11 (2). 1977 251-265. Coden; JBMRB Language: ENGLISH A new ant Ithrombogen1c polymer was synthesized by photolnduced graft copolymerization' of both a hydrophilic polymer and a cationic polymer to hydrophobic po1y(vlnyl chloride) copolymer, and by quartern1zIng and heparinizing the obtained graft copolymer. For polymers of various compositions obtained by the method described above, chemical composition, water absorption, membrane potential and quantity of adsorbed heparin wore determined and ant IthrombogenlcIty evaluated In vivo [In dogs). The polymer of excellent ant 1thrombogen1c 1 ty had a negative membrane potential, a moderate elution rate of heparin. adsorbs heparin In a quantity of approximately 15 wt-%, and has a degree of water adsorption of about 30 wt Measurement of membrane potential was very useful for the estimation of the quantity Of the adsorbed heparin and Its Change with time. Descriptors: HEMATOL-DRUG CHEMICAL COMPOSITION WATER ABSORPTION MEMBRANE POTENTIAL GRAFT Concept Codes: BIOCHEM-PHYS1OLOGL WATER STUD(IOOII); BIOCHEM STUD-GENERAU10060); BIOCHEM STUD-CARBOHYDR.(10068); BIOPHYS'- MEMBRANE PHENOMENA! 10508); BIOPHYS-BIOENGINEERING( 105 I I ) : ANATOMY/IIISTOL-REGEN,TRANSPLANT(*11107); CARDIOVASC SYST-GENL STUDS.METHS(* 14501): CARDIOVASC SYST-BLD VESS PAIHOL(* 14508); BLOOD/BODY F LOS -GENL STUDG,ME 1HS(* 15001); PHARMACOL-BLOOD. 11EMATO AGENTS(*22008) DI A F I 1e5: BIOSIS Previews 77-83/Jan BA7502:RRM2402(See 65005896 INCUBATION OF CARBON-14 TRI CHLORO ETHYLENE VAPOR WITH RAT LIVER MICROSOMES UPTAKE OF RADIOACTIVITY AND COVALENT PROTEIN BINDING OF METABOLITES BOLT H M; BUCHTER A; WOLOWSKI L: GIL D L; BOLT W INST. TOXIKOL.. UNIV., WILHELMSTR. 56. D-7400 TUEBINGEN. W. GER . INI ARCH OCCUP ENVIRON HEALTH Coden: IAOHD 39 (2). 1977 103-112. Language: ENGLISH Microsomal uptake Irreversible protein binding of labeled trichloroethylene was measured following Incubation with rat liver microsomes In an all-glass vacuum system. If the cofactor for oxidative metabolism, NADPH, Is not added. the gaseous trichloroethylene rapidly equilibrates with the microsomal suspension. Addition of NADPH results In a further uptake of 14C-tr1 chioroethy1ene from the gas phase, linearly with time, which Is due to enzymic metabolism. This part of uptake Is Inhibited ' by some ary 11m1dazo1es and 1.2.3-benzoth1 ad Iazo1es. The compounds of greatest Inhibitory potency wore 6-chioro- 1.2.3-benzothI ad Iazo1e and 5.6-dlmethyl- - 1.2.3-benzothI ad 1azole. Part of the metabolites of 14C-tr1 chioroethy1 one formed by rat liver microsomes wore Irreversibly bound to microsomal protein, amounting up to 1 nmol/mg microsomal protein per hour. Model experiments on uptake of 14C-1rIch1oroethy1ene from the gas phase by albumin solutions and liposomal suspensions (from lecithin) showed a rapid equilibration of trIch1oroethy 1ene also with these systems. Comparison with previous analogous data on vinyl chloride revealed an about 10 times higher affinity of trichloroethylene to albumin and lipid, consistent with the behavior of both compounds In the rat liver microsomal system. Descriptors: COFACTOR EFFECT LIPOSOMAL SUSPENSION UPTAKE Concept Codes: CYTOLOGY/CYTOCHEM-ANIMAL(*02506); RADIATION BIOL-RAOTN. ISOTOP TECH(06504): BIOCHEM STUD - GENERAL( 10060): BIOCHEM STUO-NUCL ACD.PURNS.PYRM( 10062); BIOCHEM STUD-PROTEIN- S.PEPTIDES,AMINO ACD( 10064 ); BIOCHEM STUD-LIPIDS( 10066): BlOPtlYS-MEMBRANE PHENOMENA!10508): BI0PHYS-BI0ENERGETICS(tO51- 0): ENZYMES-GEN.COMPAR STUD.COENZYMS(10002): ENZYMES-PHYSI0L0- GI CAL STUDIES! 10B08): METABOLISM-GENL STUD,ME T AB PATI IW( * 13002) ; METABOLISM-ENERGY.RESPIRATION{13003); DIGESTIVE S Y ST - PI IY S 10 L.BIOCHEM! * 14004): TOXI COL-GENL/EXP STUDS,METHS(* 22501); IN VITRO STUDS-CELLULR.SUBCELL!32600) Blosystematlc Codes: MUR I DAE(06375) R&S 138557 (c. J of 858) User 3614 25Jari83 2204 unp1 nst1c1 zed vinyl ch1 or 1de-v1ny1 acetate copolymer films (0.2 .times. 15 .times. 22 mm). Foreign body (FB) tumor 1 genes Is was delayed In LOV Infected females and males by 2 mo. This result could not be explained by an effect of LDV on cellular Immunity, Inasmuch as cellular Immunity does not Influence the course of FB tumor 1 genes 1s, Descriptors: TOGAVIRUS UNPLASTICIZED VINYL CHLORIDE VINYL ACETATE CO POLYMER FILM CARCINOGEN SUB CUTANEOUS TUMOR Concept Codes: BIOCHEM STUD-GENERAL!10060): BIOPHYS-MOLECUL PROP.MACROMOLEC!10506); ANATOMY/HISTOL-REGEN,TRANSPLANT!11107) ; PATHOLOGY-THERAPY! 12512) ; BONE.UNTS,FASC,CONN/ADIP-PATHOL(- 18006); INTEGUMENT SYST-GENL STUDS,METHS(18501); ROUTES OF IMMUNIZ,INFECT.THERAP(22100); TOXICOL-GENL/EXP STUDS.METHS!*2- 2501); NEOPLSMS/NEOPL AGNTS-IMMUNOLOGY(24003); NEOPLSMS/NEOPL AGNTS-CARCINOGENS!*24007); NEOPLSMS/NEOPL AGNTS-THERAP,AGNT(*- 24008); VIROLOGY-ANIMAL HOST VIRUSES(33506); IMMUNOL/IMMUNOCH- EM-BACT.VIR.FUNG!34504); IMMUNOL/IMMUNOCHEM-IMMUNOPATHOL(34508); MEO/CLIN MICROBIOL-VIROL0GY(*36006) Blosystematic Codes: ANIMAL VIRUSES(03200); MUR I DAE(86375 ) 65003245 DELAYED FOREIGN BODY TUMORIGENESIS LACTATE DEHYDROGENASE ELEVATING VIRUS BPINTON-DARNELL M; BRAND I IN MICE INFECTED WITH WISIAR INST,. 3GTII AND SPRUCE ST.. PI 11 l. AD E t.PI II A . PA. USA . 19104. J NATL CANCER INST Language: ENGLISH 59 (3). 1977 1027-1030. Coden: JNCIA Female and male CBA/H mice were Infected with lactate dehydrogenase virus (LOV). Two weeks later. these mice and non Inf ecteO controls received duublo s.c. Implants of DIAS ^^5rFMe5: BIOSIS Previews 77-83/Jan B A7S02 ; RRM2402 ( See FlTe55 ) (c. BTOSIS 1982 Ft&S 138558 User 3614 25Jan83 2205 6S00 169-1 SYSTEMS FOR PROLONGED STORAGE OF BEEF QUARTERS SMITH G C: SIMMONS R D; CARPENTER Z L MEATS AND MEAT CIIEM. SECT.. DEP. ANIM. SCI.. TEX. AGRIC. EXP. STN., TEX. A & M UNIV., COLLEGE STATION, TEX. 77843. USA. J FOOD PROT 40 (8). 1977 527-532. Coden: UFPRD Language: ENGLISH Beef quarters were used In a study which had all combinations of the following treatments: 14 of 21 days storage. with or without PVC (polyvinyl chloride] film wrapping. with or without NaOCl spraying and with N2 atmosphere or ambient air environments. Best results for Storing beef quarters for 14 days were obtained by using PVC film (with or without NaOCl spraying); best results for storing beef quarters for 21 days were obtained from PVC film wrapped (with or without NaOCl spraying) or unprotected quarters (with or without NaOCl spraying). Use of a N2 atmosphere did not consistently decrease bacterial counts and did not improve the physical appearance of quarters. Even the best system for protecting beef quarters during 21 days of storage did not result In beef that was desirable in appearance or condition at the conclusion of the storage trial . Descriptors: BACTERIAL COUNT POLY VINYL CHLORIDE FILM WRAPPING SODIUM HYPO CHLORITE SPRAYING NITROGEN ATMOSPHERE PHYSICAL APPEARANCE Concept Codes: B IOCHEM-GASES(10012); BIOCHEM STUD-GENERAL( 1- 0060): FOOD TECH-MEAT.MEAT BY-PRODUCTS(* 135 1 6 ) ; TOOD TECH-EVALNS PHYS.CIIEM PROPS(13530); FOOD TECH-PREP.PR0CES5NG- . STORAGE(*13532); MICROBIOLOG APPARAT.METHS.MED IA(32000): MED/CLIN MICROBIOL-BACTERIOLOGY(36002); PUB HEALTH-I NANIMATE OIS VECTORS!37060); PUB HEALTH MICROBIOL(37400) ; FOOO/INDUS MICRO-FD/BEV SP CNI AM(39002); DISIN( ECTI ON.0 ISINFECTANTS.STE- RL(39500) BlosystnmatIc Codes: BACTER(A-UNSPECIFI ED(06000); B0VIDAE(857 15 ) PLSMS/NEOPL AGNTS-CARCINOGENS(*24007); NEOPLSMS/NEOPL AGNTS-B- LOOO.RES(*24010); PUB HEALTH-ADMINISTR.STAT I ST ICS(37010); ENVIRON HEALTH-OCCUPATNL HEALTH(37013) BlosystematIc Codes: 1I0M1NIDAE(86215): CRICETI DAE(86310) 15056469 IDENTIFICATION OF CARCINOGENS BY MUTAGEN TESTING IN DROSOPHILA THE RELATIVE RELIABILITY FOR THE KINDS OF GENETIC DAMAGE MEASURED VOGEL E HIATT. H. H.. J. 0. WATSON AND vJ. A. WINSTEN (ED.). COLD SPRING HARBOR CONFERENCES ON CELL PROLIFERATION. VOL. 4. ORIGINS OF HUMAN CANCER. BOOK A. INCIDENCE OF CANCER IN HUMANS. COLD SPRING HARBOR. N.Y.. USA. SEPT.. 1976. XXVI+602P. (BOOK A); XIV+699P. (BOOK B); XIV+583P. (BOOK C). ILLUS. MAPS. COLD SPRING HARBOR LABORATORY: COLO SPRING HARBOR. N.Y.. ISBN 0-87969-119-0. 1977 1483-1497 COden: 06398 Descriptors: NATULAN DI ETHYL NITROSAMINE METHYL METHANESULFONATE A70XY METHANE N NITROSO MORPHOLINE VINYL CHLORIDE CYCLO PHOSPHAMIDE TROFOSFAMIDE IFOSFAMIDE Concept Codes: GENETICS/CYTOGENET-ANIMAL(*03506): BIOCHEM STUD-GENERAL( 10060); PA IT IOLOGY- THERAPY( 125 12): PHARMACOL -GENE - RAL SIUDIES(*22002); TOXICOL-GENL/EXP STUDS,METHS(2250 I): TOXICOL'PHARMACOLOGICAL(*22504); NEOPLSMS/NEOPL AGNTS-CARCINO GENS (*24007); NEOPLSMS/NEOPL AGNTS-THERAP,AGNT(*24008 ) : CHEMOTHERAPY-GEN STUD.METH.METAB(*38502); INVERTB PHYSIOL-INSECT A - PA THOL(*64078) BlosystematIc Codes: 0IPTERA(753 14 ) 15056491 VINYL CHLORIDE A CASE FOR THE USE OF LABORATORY BIOASSAY IN THE REGULATORY CONTROL PROCEDURE WAGONER J K; INFANTE P F HIATT. II. H.. J, 0. WATSON AND J. A. WINSTFN (FD.). COLD SPRING harbor CONTERENCES ON CELL PROLIFERATION, VOL. 4. ORIGINS 01 HUMAN CANCER. BOOK A. INCIDENCE OF CANCER IN HUMANS. COLD SPRING HARBOR, N.Y., USA. SEPT.. 1976. XXVH602P. (BOOK A): X1V1699P. (BOOK B); XIV*583P. (BOOK C). ILLIJS. MAPS. COM) SPRING HARBOR LABORATORY: COLD SPRING HARBOR. N.Y.. ISBN 0-87909- I 19' 0. 1977 1797-1805 Codon: 0639(1 Descriptors: HUMAN CHINESE HAMSTER CARCINOGEN OCCUPATIONAL CXPUSURF BRAIN RESPIRATORY LIVER BILIARY HEMATOPOIETIC CANCERS Concept Codes: SOCIAL BIOL/IIUMAN ECOLOGY(05500); BIOCHEM STUO-GENERAU 10060) : DIGESTIVE S Y ST - P A Tl IOLOG Y ( * 1 4006 ) ; BLOOD/ROOY FLOS-BLD.LYM.RES PATH(* 15006): BI.OOD/BOOY FLDS-LYMPHAT TISS.RES( 15008): RESPIRATORY SYST-PATIIOLOGY ( * 1G- 006); NERVOUS SYST-PATHOLOGY(20506); TOXI COL-GENL/EXP STUDS.METHS( *22501): TOXI COL-ENVIRONMNIL. INDUSTIH *22506); NCO-