Document 990XrGdqaG74ZxZBGvzNBZQ2p
Monsanto
Fred D. Hileman - ESC/Dayton Laboratory
|K .V [ - lO C tllp K -^ H O h l .
11 December 1984 Corrections for Report 0MDA-56O
T O : J. F. Pysz - Q4C R. F. Ivory - 1250 Central Files - 1250 Technical Reports Library - R2C
Ext. 211
The results in Table 1 of Report No. MDA-560 were incorrect for sample 012. A copy of the corrected results Is attached.
FDH/bd Attachment
Fred D. Hileman
SUBJECT TO rV;Ci
-j
DRAFT
Hazard from exposure to higher chlorodibenzodioxins
a. The Centers for Disease Control accepts 1 pg/(kg body mass)/day of 2,3,7,8-TCDD as an acceptable daily intake. (R.D. Kimbrough, H. Falk, P. Stehr and G. Fries, J . Tox. Env. Health, 1984, lA, 47-93)
b. EPA is said to have accepted that amount as an Acceptable Average Daily Intake for calculating water-quality numbers.
c. Other chlorodibenzodioxins are known to be less toxic in acute doses and to be less active in various biological effect tests than 2,3,7,8-TCDD.
(See summary prepared by A. Peter, attached.),
d. In particular, octachlorodibenzodioxin and 1,2,3,4,6,7,9heptachlorodibenzodixoin are found to be practically nontoxic.
(See summary.)
e. Background intake of 2,3,7,8-TCDD approximates 1 pg/kg/d. Intake of higher chloro cogeners is probably >5 pg/kg/d (by inference from body burden estimations).
SUBJECT l
TADLE 1. ANALYSIS OF TETRACHLOROPHTHALIC ANHYDRIDE
Sample
Tetrathal 1 " Tetrathal H2 Tetrathal 3 Tetrathal #4 Tetrathal 5 Tetrathal #5 (replicate) Tetrathal #6 Tetrathal 7 Tetrathal 0 Tetrathal H9 Tetrathal 10 Tetrathal 11 Tetrathal 11 (replicate) Tetrathal 12 Method Blank 1 Method Blank #2
Method Detection Limit
Spike Level Tetrathal 1 (high spike) Recovery \
Spike Level
Tetrathal H3 (low spike)
"Cl ri
Recovery %
p -ifvlSpike Level O f/'-*Tetrathal 8 (high spike) * ^' ''Recovery \ * < - i
f * "Jspike :T;; : -Tetrathal #9
r`, ;Recovery \
*'j
;
(low spike)
C12 Cl3
ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND ND
11
25 28 7.7 14 31 50
2 . 6 28 1.0 1.9 30 68
26 29 16 17 62 59
2.5 2 .8 1.2 <22 ' 48
SUBJECT TO
FOR POLYCHLORINATED DIBENZO-P-DIOXINS (PCDDs)
ng PCDDs/gm Sample (ppb) c i M Cl s
Cl7
Cl 8
ND ND ND ND ND ND ND ND ND ND ND ND ND 1.5 ND ND
1
20 11 55
2.1 ` 1.5 71
21 17 81
2.0 1.5 75
ND ND ND ND ND ND ND 1.0 ND 1.8 16 ND ND 14 ND ND
1
24 13 54
2.5 1.6 64
25 19 76
2.4 3.9 88
9.7 ND ND 4.6 ND ND 1.3 4.4 ND 6.0 82 4.5 5.5 43 ND ND
1
23 24 62
2.4 2.4 100
24 23 96
2.3 9.0 165
77 5.4 5.1 25 8.0 4.4 9.0 20 6.8 28 210 35 39 110 ND ND
1
25 101
-
2.6 8.3
--
26 38
120
2.5 41
-
190 99 27 57
150 74
530 63
390 65 87
110 130 250
ND ND
1
20 250
--
2 29
--
21 790
--
2.0 87 -