Document 95KEJK2qJjXgvQd5BbmEZOp6

EXHIBIT A THE DATA BASE FOR INDUSTRIAL BIO-TEST CHEMICALS \ Exhibit A quantitatively presents the data base of the chemical compounds for which studies were conducted by Industrial Bio-Test Laboratories. The IBT studies are designated by the letter 0. Studies in the EPA data base done by labs other than IBT are designated by the letter X. The studies are arrayed across six categories of chronic effects. These chronic effects are: oncogenicity, terato genicity, mutagenicity, reproductive effects, neurotoxicity, and other chronic effects. Some of the chemicals in this exhibit appear to have no IBT studies because the studies conducted for these chemicals by IBT were all in the acute categories. The chemical names used are those that were listed in the IBT records. There is no designation of the validity or invalidity of the IBT studies presented. Specific information of thiss nature is in Exhibit B. Exhibit A also notes any ongoing regulatory activity that will generate chronic data ror these chemicals. The types of regulatory activity that cause the generation of data are: the registration standard program, the data call in program, the rebuttable presumption against registration program, and any special action employing the 3c2b provision of the Federal Insecticide, Fungicide, Rodenticide Act. There are approximately 2850 chronic studies indicated in this data base. CHEMICAL COMPOUNDS TESTED BY INDUSTRIAL BIO-TEST LABORATORIES: A QUANT ITATlVB~PRE5E NTA'riON OF STUDIES' SUBMITTED tO fepA t>Y~TBT AND OTHER LABORATORIES. CHEMICALS n ffncc <uJ h-4 U PC i--i w PC IO wo oH o < c_> (X PC w oH M u PC w u < g li . ( l u tg~4 H U fhc-t -I PE uH X opi n in o C m DH H H O U o PC(J PC Ul IX IX w tx p 5 w lU w a: ix H lx REGULATORY ACTIVITY TO pcw PC o w GENERATE CHRONIC DATA Resmethrin xxxx Ronnel Rydex (Prodiamine) Santophen X 0 Sectrol X XXXXXX 000 XX 0 0 xxxx 0 X0 00 XXXXXXX X Sencor Simazine Sodium Azide X 0 XX 0 XXX 000. X 0 XXXXXXX 0' XX xxxxx XXX XXX 0` 0 X=9 XX XXX xxxx 'X-25 X=9 X XXXXX XX 0000 X=20 0 XXX XXXXXXX 0 XXX Discontinued Product Not Registered No Food Use Data Call In l Sodium Bromi de Sodium Ch: X ! 1 1 EXHIBIT B IBT TRACKING SYSTEM REPORT IBT TRACKING SYSTEM REPORT CODE DEFINITIONS VALIDATE: a review designed to determine if the information in the final report was supported by the raw data from the study. I - Invalid. The information in the final report was not supported by the raw data from the study. P - Pending. The study is still under validation Teview. S - Supplemental. Portions of the study are valid and can be used independently of the remainder of the study. V - Valid. The information in the final report is supported by the raw data from the study. EVALUATE: a review d gu idelines pe Stic ide to determine if a study meets Agency c, CM - Core minimum r eqiiirements S, CS - Core supplem stud ies. X, Cl - Core invai id requ irements to support registration. p - Pend ing. The stud'r is still under evaluation review. 'A Not applicable. Tne study was not given an evaluation status if the validation process determined it to be invalid. REPLACE: the column indicating the replacement status of the study Replaced Discussion Not Req No Resp Neg Resp Study - Repla< Study No re: Nega t: :placed or in progress from registrant I_NUM CHEMICAL COMPANY ROUTE TYPE SPECIES VALIDATE EVALUATE REPLACE {Il-i li :;-224 *'>5643 `51-7145 ' -C4 476 * .t7; .--; ! j 5524 j -32C'' :-274A ?-?3?4 S50-P771 %3-f>eo J-23? A - 1335 V 71 S3 B-1174 R-5062 I1 - 5 G A B-5065 B-5083 '-5084 1173 *7-117? : 1175 621-1172' ::-ii7 663-628? E-1751 J-7214 621-1174 B-4B06 C-490? 621-06952 623-6953 623-7090 651-0791 f; 55S0 T ir^n J. i ^ i: * 172 A-2007 . B-2010 C:-2 0 0 ? C-2011 F-2C-J4 :. k -m J 74 PR0DIAKINE PRODIAMINE PRGDIAKINE PR0D1AKIKE PROFLURALIN PROFLURALIN PROFLURALIN r r 9F!_'JRALIN PROMT OH FROHETRYN PROFHAH PROf'KAH PROPHAH FROUL froul . PRDUL PYRETHRIN RABON ramrod RAMROD RAMROD RAMROD RAMROD RAMROD RAMROD RAMROD RAMROB RAMROD RAMROD RAKROB RAMROD RAHROD RAKROB RAMROD RAHROD RANDOX RAKBOX RANDOX RAHBOX RAHDOX RAHBOX RESKETHRIN RESHETHRIN RESHETHRIN RESHETHRIN ROHHEL SAHTDF'HEH SAHTOPKEH SAHTDF'HEH SANTQF'HEN SAHTOF'HEH SANTOPHEH SAHTOF'HEH VELSICOL UELSICOL VELS3C0L VEL5IC0L CIBA GEIGY CIBA GEIGY CIBA GEIGY CIBA GEIGY CIBA GEIGY FHC PPG PPG PPG AMER CYAHIKIB AMER CYAHIKIB AMER CYAHIKIB HGK SHELL MONSANTO MONSANTO MONSANTO MONSANTO MONSANTO MONSANTO 1 MONSANTO MOHSAHTO 1 MONSANTO KONSAHTO HDNSANTD MOHSAHTO MONSANTO MOHSAHTO MONSANTO MONSANTO MONSANTO MOHSAHTO MONSANTO MONSANTO MOHSAHTO MOHSAHTO MOHSAHTO ORAL ORAL ORAL BERMAL DERMAL ORAL ORAL INHALATION DERMAL DERMAL ORAL ORAL ORAL ORAL ORAL ORAL INHALATION DIETARY ORAL ORAL ORAL ORAL ORAL BOU MONSANTO MONSANTO MOHSAHTO HDNSAN70 MONSANTO MONSANTO MONSANTO T1SS/SKEL ' DERMAL ORAL ORAL ORAL INHALATION TERATOLOGY SUKHRDifIC CATARACTEGEN CARCINOGENICITY TERATOLOGY SUBCHRONIC SUBCHRONIC TERATOLOGY SUBACUTE SUBACUTE TERATOLOGY TERATOLOGY CATARACTEGEN TERATOLOGY SUBACUTE SUBACUTE CARCINOGENICITY CHRONIC CHRONIC REPRODUCTION SUBCHRONIC SUBCHRONIC CHRONIC MUTAGENICITY TERATOLOGY CHRONIC REPRODUCTION SUBACUTE SUBACUTE SUBACUTE CHRONIC REPRODUCTION MUTAGENICITY TERATOLOGY sutcwi: TERATOLOGY TERATOLOGY TERATOLOGY TERATOLOGY SUBCHRONIC SUBCHRONIC SUBCHRDNIC SUBCHRONIC MUTAGENICITY TERATOLOGY SUBACUTE RABBIT DOG HEN HOUSE RAT DOG RAT RABBIT RAT RABBIT RAT DOG HEN RAT RAT HEN HOUSE RABBIT RABBIT RABBIT MOUSE RAT DOG RAT RAT DOG BOG HOUSE RABBIT RAT RAT RAT QUAIL QUAIL MOUSE RAT DOG RAT RAT MOUSE RABBIT RAT RABBIT RABBIT MOUSE RAT RABBIT RAT DOG DOG MOUSE RABBIT RAT I I I I V V V I s I 1 I V I I V V I I I I I I 1 I I I J I I I I V I I I I I I V I I I I I I I S I I I I I NA NA NA NA NA 1IA NA P NA NA NA V NA `NA CM P NA NA NA NA NA NA NA NA NA NA NA NA HA NA NA V NA NA NA . NA NA NA Cl NA NA NA NA NA NA NA S NA NA NA NA NA NO RESP NO RESP NO RESP NO RESP NOT REQ NEG RESP NEG F;EBF NEG RESP NO RESP NEG RESP REPLACED NEG RESP NEG RESP REPLACED REPLACED NEG RESP NO RESP REPLACED NOT RED NEG RESP NEG RESP NOT REQ NOT REQ NOT REQ NOT REQ NOT REQ NEG RESP NEG RESP NEG RESP NEG RESP NEG RESP NEG RESP NOT RED REPLACED NEG RESP NEG RESP NEG RESP NEG RESP NO RESP NEG RESP REPLACED REPLACED REPLACED REPLACED NEG RESP NO RESP NO RESP NO RESP NO RESP NO RESP NO RESP NO RESP IE7.WJH CHEMICAL COMPANY ROUTE TYPE SPECIES VALIDATE EVALUATE REFLACE 622-2012B 622-2012C -8562-S40S ?-?09 r.-;;so E-8922 J-1851 j_*m J-9027 Et-9071 B-9244 8532-SS V 8580-8907 622-3540 B-5664 C-5665 B-94 95BO-93BO A-719B 2705 M374B '^ 8-379? 8-4538 B-S210 B-8211 C-8270 C-S271 P-S272 A- 8 T50 tj r-vo 1 A 5*56 B-3??? J-52S6 8523-10590 8521-8238 8533-9630 8560-8337 B560-9361 3580-10725 B 1056 8-2661 T-2665 rt- . T firuou r . C-^Ar I9 .M *il1 6885 651-7054 F--4C03 P - 4025 SANTPHEN SANTOPHEN ` 5ECTR0L SENCOR SENCOR SENCOR SENCOR SENCOR SENCOR SIHAZINE SIHAZINE SIHA2INE SIHAZINE SODIUM AZIDE SODIUM CHLORATE SODIUM CHLORATE SUH1T0L SUPRACIDE SUPRACIDE TEDION 1E O T OS TERBUTHYLAZINE TERBUTHYLAZINE TERBUTHYLAZINE TERBUTHYLAZINE TERBUTHYLAZINE TERBUTHYLAZINE TERBUTHYLAZINE TERBUTHYLAZINE TERBUTHYLAZINE TERBUTHYLAZINE TERBUTRYN TERBUTRYN TERBUTRYN TERBUTRYN TERRAZOLE THIB1AZUR0N THIUIAZURON THIDIAZURON THID1AZUR0N THIDIAZURON TH1DDAN THIODAN THIODAN THIODAN THIODAN THIODAN lHUHiftN imODAN THIOFANQX THIOFANOX THIOFANQX TORAK TORAK MONSANTO' MONSANTO 3H CHEMAGRO CHEHAGRO CHEMAGRO CHEMAGRO CHEHAGRO CHEHAGRO ' CIBA GE1GY CIBA GEIGT CIBA GE1GY CIBA GEIGT PPG CIBA GEIGY CIBA GEIGY CIBA GEIGT FHC AHER CYANIHID CIBA GEIGY CIBA GEIGY CIBA GEIGY CIBA GEIGY CIBA GEIGY CIBA GEIGY CIBA GEIGY CIBA GEIGY CIBA GEIGY CIBA GEIGY CIBA GEIGY CIBA GEIGY CIBA GEIGY CIBA GEIGY OLIN NORAH NORAH NORAH NORAH NORAH FHC FHC FHC FHC FHC FHC FHC FHC DIAMOND SHAMROCK IilAHONU SHAMROCK DIAMOND SHAMROCK BFC BFC INAHLAT10N ORAL ORAL ORAL ORAL ORAL ORAL ORAL DERMAL ORAL ORAL ORAL ORAL ORAL ORAL DERHAL DERMAL DERHAL ORAL ORAL ORAL ORAL ORAL ORAL ORAL ORAL ORAL ORAL ORAL ORAL REPRODUCTION TERATOLOGY CARCINOGENICITY SUBACUTE MUTAGENICITY TERATOLOGY TERATOLOGY TERATOLOGY SUBCHRONIC SUBCHROHIC SUBCHRONIC CARCINOGENICITY TERATOLOGY TERATOLOGY CHRONIC REPRODUCTION TERATOLOGY TERATOLOGY SUBCHRONIC SUBCHRONIC CHRONIC CHRONIC SUBCHROHIC CHRONIC REPRODUCTION TERATOLOGY TERATOLOGY SUBCHRONIC REPRODUCTION SUBCHRONIC CHRONIC ONCOGENICITY TERATOLOGY SUBACUTE SUBACUTE CHR0N1:', CHRONIC MUTAGENICITY REPRODUCTION SUBCHRONIC NEUROTOX HEUR0TOX SUBACUTE . SUBCHROHIC RAT RAT RAT HOUSE DOG MDUSE RABBIT RABBIT RABBIT RAT RAT MOUSE HOUSE RAT RAT DOG RAT HOUSE RABBIT RAT RAT RAT RAT RAT RAT RAT DOG DOG RAT RABBIT RABBIT RAT RABBIT RAT DOG RAT DOG RAT RAT RAT HOUSE RAT RAT DOG DOG DOG HOUSE RAT HEN RAT CHICKEN CHICKEN RAT RAT P I I I V 1 I I I I I I I I I I V S V I I V I I p I 1 1 p p I V I I I s s V 5 S V I I I V V V I V I V V I` I NO RCSF NA NO F:ESF NA REPLACED NA REPLACED P NO RESP NA REPLACED NA REPLACED NA REPLACED NA REPLACED NA REPLACED NA NOT REQ NA NEG RESP NA DISCUSSIQN NA NOT RE CI NA NEG RESP NA NEG RESP NA NO RESP P REPLACED NA REPLACED NA NEG RESP NA NO RESP NEG RESP NA NEG RESP NA . NEG RESP NEG RESP NA ' NEG RESP NA ' NEG RESP NA ; NEG RESP NEG RESP NEG RESP NA NEG RESP REPLACED NA NOT REO NA REPLACED NA REPLACED S REPLACED CS- REPLACED C NEG RESP CS NOT REQ s REPLACED c NEG RESP NA REPLACED NA REPLACED NA REPLACED P HD RESP P NOT REO Cl REPLACED NA REPLACED V NEG RESP NA NO RESP P NO RESP P NOT REO NA NEG RESP NA NEG RESP