Document 94XJ2Zo8Oxr8wVgV5eooVY8q

toocm pramn. guana Z9 ii.o:-<j hna icon considerable toxicity research un pyaraul ?-9, Attached \ a discussion and interpretation of the toxicity studios. Tho result* an also ounuarlaed in a nrlofor fashion on paie lh of the onoloaed Pydraul >'-9 Technical bulletin. Ili Oral u*jQ of 14.3 grama par Ailogram when tooted with rata, and tho Oral Minima* lethal Dooc of 4.85 to 5.00 frame par kilouraift wtion tested with rabbits Indicate that Pydraul 085 nay bo clooted sa relatively harmless' to slightly taxis' from the standpoint of oral l/^oatlon. Potential irritation studios with rabbits slice* that it la only a mild irritant to skin and eyes. In touts vapor intimation studies, rats survived a '--hour exposure to atnoapharos saturated with vapors or the product. The above figure# are lower than those obtained in studies with Pydraul P-9. This oonparlson la significant since Pydraul P-9 has bsan used slnea 1949 with no roperta of sltln irritation or other tocxlo effaeta. _ Pydraul 150 The toxioity report on Pydraul 15O lndloatea that it la praatloally innocuous whan fed orally to rats sines the anlsala survived single doeea of 86.5 raws per kilogram with loss of appetite and savers diarrhea as the only tootle effaeta. The fluid apparently la not absorbed through Uie unorokan skin of rabbits alma this spec lea survived doses up to 9.5 grant par idlograa of body weight, in rabbit aicin and eye irritation studies, Pydraul 1`jO waa no acre irritating then a 10* soap solution tested similarly. As indicated with Pydraul f-9, how ever, Pydraul 150 will cause severe pain If there is accidental splashing in the eyes of humans. Rata survived a 6-hour ex posure to an atmosphere saturated with rydrsul 150 vapors, Wmk,tHSfl Our interpretation of the toxicity data obtained on this newer synthotla hydrauiia fluid is that sosidental ingestion is not a pArtloular hasard in view of the high oral lethal doss (oral hDrjQi 10,500 mg/Va). similarly, single masalva skin exposure!^should not be Immediately hasardous (akin MLOi 685 to 1,850 mg/kg). The lethal dose following skin penetration la such, however, that prolonged and repeated akin contact should be avoided. Such exposure must also be avoided te pre vent skin irritation, we also feel that vapor inhalation should be avoided *dwn the fluid la at elevated temperatures. Such exposure again relate# to prolonged or repeated exposures rather than massive or acute exposure. In the ease of the latter, workman would probably not voluntarily subject thasiaelvaa to concentrations that are hazardous for short periods. HONS 071290 -2- In aniaal toxicity studios mth rydnsul 1C, tho oral Uttnl doaa In rata rabbits, 3.5 la to apprenlaatoly 4.3 graaa par HO grans klloaran. panrak-lgiargaraatnaraandanTaol-r tivlty of raMalta la typlsal of this typa of fluid, itua laths! doaa la of auoh as ordar, houavar, that tha fluid mx to aonaldarod only "slightly tools" to nan fron tha standpoint of aoaldantal ingsstlon of singls oral doaaa. Tha fluid nay ba abaorbod through tha unbrohan skin of rabbits in doaaa rasuiting in daatfc, but again tha alnlaass lothal doaa la sush that aoaidontal nasalva akin aapoauraa to aan do not passant a basard. Akin and ays irritation studios with rabbits Mould classify tha fluid as a slid irritant. laboratory anlaals aurvlvad six-hour exposures to an atnoaphara aaturatod with tho vapora of tha fluid, on tha basis of this data* it la ooneludad that Pydraul AC requires no apoalal handling prt- sautlana ethar than avoiaing prolonged or rapaatod akin oontaot. Aoaldantal aplaahtng la tha eyes will raault in aadaaataly vara pain and Irritation but no paraanent dawagt should roaulb. HONS 071291