Document 93xEbezen3NvagO60m723k1B5

v fel C=3 Industrial Hygiene Digest May, 196t 467 Inhibition of Oxidation of Benzene by Certain Antioxidants. Zh. I. Abramova and I. D. Cadasl Federation Proc. 25i, Part IX (Translation Supplement) T91-T92 (Jan. -Feb. 1966). Experiments with liver homogenate in vitro showed, that several antioxidants (propyl galtate cystamine, cystine, methionine) inhibit the oxidation of benzene. Experiments in vitro with liver homogenates of rabbits receiving methionine revealed depression of the oxidation of bei zene. Experiments in vitro with homogenate of livers from rabbits with subacute benzene pc ing, receiving methionine and cystamine at the same time, revealed inhibition of benzene oxi dation. Excretion of bound sulfur and glucuronides was reduced in rabbits with subacute ben. poisoning receiving sulfur-containing compounds at the same time. -- Authors' conclusi 468 Factors Influencing Hazards in Isocyanate Foam-Spraying. K. E. Grim and R.E. Knox. Am. Ind. Hyg. Assn. J. 7, 62-67 (Jan. -Feb. 1966). Controlled foam-spraying experiments conducted in a sealed, unventilated room were designi evaluate the influence of formulations and application techniques on atmospheric contaminatio with isocyanates. The conditions for sampling the atmosphere during application of formulat involving TDI (toluenediisocyanate) and MDI (methylenebis(4-phenylisocyanate) are described detail. The Elastomers Laboratory spray gun, which mixes the chemicals internally, is corr pared to a conventional external-mix spray gun. Equipment for quantitative measurement of and MDI retained by activated charcoal canisters is described, and results are given. Recon mendations of the safest method of foam-apraying based on information acquired, and safety j cautions, including the use of operator protection equipment, are discussed. Nine referencei are given. .. Authors' abst. 469 Ethanol Potentiation of Halogenated Aliphatic Solvent Toxicity, H.H. Cornish and Julita Adel Am. Ind. Hyg. Assn. J. 27, 57-61 (Jan.-Feb. 1966). Ethanol potentiation of toxcity could be readily demonstrated in rats exposed 18 hours later to carbon tetrachloride or trichloroethylene vapors, but not in those exposed to perchloroethyler or 1, 1, 1 -trichloroethane. Serum enzyme levels and histopathologic studies served as a mea ure of toxic response. Subsequent exposure of ethanol-treated rats for eight hours to 25 or 5 of carbon tetrachloride or to lOOppm of trichloroethylene failed to affect serum enzyme level: However, ethanol potentiation of carbon tetrachloride toxicity could be demonstrated after as an exposure as two hours at lOOppm, and potentiation of trichloroethylene toxicity was appare after a four-hour exposure to 5, 000ppm. Ten references are given. -- Authors' summary 470 Epoxy Hazards in Industry. The Hazards and Their Control. W.E. Broughton. Ann. Occ. Hyg. (London) 131 (1965). The main components of the epoxy resins in commercial use in England over the past two deci and their attendant hazards are identified. It is reported that no systemic intoxication of any significance has been associated with epoxy resins, but that both uncured resins and hardener can produce dermatitis and occasionally a sensitization after repeated contact with the skin. Hardening agents containing amines are said to be more irritating than uncured resins, which become increasingly inert as their molecular weight and viscosity is increased. The experie: of several large plants manufacturing resins and the tabulated incidence of dermatitis at one o them over a period of approximately seven years are presented. Proper personnel selection, use of protective clothing and devices, instruction of employees on the nature of the hazard an proper work techniques, good plant layout, and adequate ventilation are the main points includ in a description of means by which effective control of the hazards may be achieved. J. Occ. Med. Absts. INDUSTRIAL DUSTS I 471 Mesothelioma Associated With Asbestosis. A Report of Three Gases. R.H. Mann, J. L. Gro and W.M. O'Donnell. Cancer 19. 521-526 (April, 1966). A study of 54 autopsies of patients dying with pulmonary asbestosis disclosed three cases of peritoneal mesothelioma, one of which was'complicated by a mesothelioma of the pleura. In fr of the three patients there was an occupational exposure history of 20 and 34 years in an asbes textile plant. Although the remaining patient had classical asbestosis of the lungs at autopsy, was no known history of industrial exposure to asbestos. The authors think asbestos can prodi mesothelioma of either peritoneum or pleura; they present three cases to support the concept a causal relationship. The increased utilization of asbestos material and the recent demonstr; of asbestos bodies in the lungs of urban dwellers'may have significant implications for cancer epidemiology in the future. .3, -- Authors' abst. 03122134