Document 93n5QveKjBzx2Y8oE302gakQL

FILE NAME: Johnson & Johnson (JAJ) DATE: 1971 Nov 10 DOC#: JAJ054 DOCUMENT DESCRIPTION: Letter to J&J from Mt. Sinai School of Medicine MOUNT SINAI SC H O O L OF MEDICINE ojTht City Uiibnsily qJN <wYork F I F T H A V E N U E A N D J OOTH S T R E B T * N E W Y O R K , N .Y . I Q0J 9 iftirhntnt f/CemmunltyUMiYinf N ovem be r 1 0 , 1971 Dr. Gavin HIIdick^-Smlth Director o f C lin ic a l Research Johnson and Johnson Research Division . Mew. Brunswick, New Je rse y . .. * -Dear'"Dr. H'HxH'ck-,,SnvH:fr; , . I have In fro n t o f me a le t t e r dated August 9, 1971 addressed to Dr. S e lik O ff in d ica tin g your wish to receive some Informa tio n on the Tenovus sample that you so kindly len t to u s. I have been p u ttjn g o f f answering th is le tt e r not because 1 am a f e is t y devil so much as the fa c t th at i lo s t the le t t e r on my desk! I c a lle d your o f f i c e la s t week. You were out and I I fe e l th at I would do as well to report to you in w ritin g . In respect be the Tenovus samples th at were sent to 'u s , we made the follow ing ob servatio n s. We did fin d some grains th at i resembled ta lc with the usual electron d iffra c tio n pattern c o n s is te n t fo r a sheet s i l i c a t e stru c tu re . A gain, we have no d e f in it iv e means o f Id e n tify in g the p a r tic le on the b a sis of r. I t s e le ctro n d iffr a c t io n pattern in that many sheet s ilic a t e s y ie ld a s im ila r array o f sp ots. We assume that the p a r tic le s were t a l c o r , rath er, were co n siste n t with t a lc . Vie a ls o got a few su rp rises in th at we observed some c h r y s o tile asbestos to. b presen t In the tis s u e as w e lf. Vie have been kicking th is observation around the Laboratory fo r a w hile and we might consider a p u b lica tlo n somewhere - - j y s t a short note In d ica tin g that we have observed these m aterials preserit in the tissu es. We have a ls o analyzed one o f your t a lc samples In some d e t a il. In a d d itio n to the normal p la ty t a lc presen t, we have observed many "fib ro u s ta lc s " as v/el V. This fib rou s ta lc m aterial c lo s e ly resembles normal p la ty t a lc but appears with a greater length a s p e c t, I t 's;. term inations re prism term inations and Protected Document-Subject to Protective Order JNJAZB6. I j> fc ./ i i ** % t Dr. Gavin HI. 1dlck-Smi ' Page Two November 10, 197.1 * ; and the general c h a r a c te r is tic s under the electron microscope do Indeed resemble .normal t a l c . Electron d iffr a c tio n on ^ho&e~g^Us-^a4MV-JfU4-ds-these grains 3ga?n yields a ta lc . ' pattern which is a very w el1-d efin ed hexagonal array o f spots. We a ls o observed trace amounts o f c h r y s o tile asbestos only When the t a lc was so n ifie d and markedly dispersed. The amounts o f ch ryso ti le are r e la tiv e ly sm all, occurring .in.am ounts, we estim ate, a t le ss than .01%, The J & J baby t a l c is o f qu ite ` high q u a lity and as a matter o f f a c t , in re la tio n to the number o f samples we have examined thus f a r r i t Is the "purest1?, We j u s t thought th at v/e would pass th is information along to you as our colleagu es in s c i e n t i f i c research and you may use I t as you w ish. A gain, many thanks for giving us the samples and allow in g us to look them over. In c id e n ta lly , I am very In terested in ob taining some o f your m aterial c a lle d sodium s e s q u ic itr a te which has been bandied about as possessing a. stru ctu re th at is not u n lik e c h r y s o tile . Do you think you could have one o f your research boys send me-some o f th is? ` A gain, many thanks, and if.y o u need any further inform ation, AML:Ikh P Protected Document-Subject to Protective Order JNJAZ55_00000S255 t . Y fiPP ** H Protested Docum ent-Bu^ectto Protective Order JN JA Z _0 H X tS2 S3