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r 1S10 f RONTAGi ROAO \ NORTHBROOK, ILLINOIS 60Q62 REPORT TO IBT RESEARCH POXICITY AMD REPRODUCTION STUDY WITH AROCLOR 1242 IN WHITE LEGHORN CHICKENS JUNE 7, 1973 IBT NO. JI291 C ( 4 EXHIBIT DSm 036367 kiifEka.s'T HARTOLDMONO015606 JndtuUial BIO -TEST J!cz6otaiyueS. Snc. 1810 CRONTAGI ROAO ' NORTHBROOK. IUINOIS 00062 June 7, 1973 Mr. Elmer P. Wheeler Monsanto Company 800 N. Lindbergh Boulevard St. Louis, Missouri 63166 Dear Mr. Wheeler: Re: I3T No. J1291 - Toxicity and Reproduction Study with Aroclor 1242 in White Leghorn Chickens We are submitting herewith our laboratory report dated v June 7, 1973 , prepared in connection with the above study. Very truly yours , JCC/kjl J. C. Calandra President OS x 036366 HARTOLDMONO015607 S~L*l*ial B I o - T E S T laim^aAUK r REPORT TO IBT RESEARCH TOXICITY AND REPRODUCTION STUDY WITH AROCLOR 1242 IN WHITE LEGHORN CHICKENS JUNE 7, 1973 IBT NO. J1291 . I. Introduction A toxicity and reproduction study with Arcelor 1242 in while Led;: . a chickens was initiated. This report presents the results of the investiga tion conducted at V/edge's Creek Research Farm, Industrial 310-TEST Laboratories, Inc. CSW 036369 HARTOLDMONO015608 3"4fuLi+d B l O - T E S T 3*0. II. Summary ' A toxicity and reproduction study was conducted in white Leghorn chickens fed Aroclor 1242 at dietary levels of 1.0, 3.0, and 10.0 ppm. The results of this study were as follows: A. Toxicity Phase ' No effects upon weight gain, food consumption, survival, egg production, egg weight, egg shell thickness or egg specific gravity were observed. A slight increase in the number of defective eggs and a severe decrease in the hatchafciLity of eggs were recorded for the group fed 10 ppm. Data obtained from the 1 and 3 ppm groups were essentially normal. v. A gross pathological examination of all chickens revealed no significant abnormalities. B. Reproduction Phase ' r, Chick survival was not influenced by the ingestion of Aroclor 1242. A slight decrease in chick weight gain was recorded for the 10 ppm' group. Weight gain for the 1 and 3 ppm, groups was considered normal. ' . .. DSN 036370 HARTOLDMONO015609