Document 933vpZmDZVdYJzrxBb3one5wR

b4> NOTE TO FILE - OPPTS 50639 October 23, 2000 FROM: Karen Lannon SUBJECT: Revised PFOS Hazard Assessment M S A 6 _ 03lf-& Attached is a revised PFOS Hazard Assessment. Minor changes from the text in the original version (August 31, 2000) are found on pages 6, 7, and 26, and concern the corrected 1974 reference to Biesemeier and Harris. The conclusions were not affected by these changes. CC--rcD"o}r4v O--o--r>TroOrnn r?rn rrcooo 0 Contain NO CBI I Hazard Assessment and Biomonitoring Data on Perfluorooctane Sulfonate - PFOS I. Executive Summary ms3plIene0ovar-phuen4uulmu4lmofaapctfacipoon5tblu4nl.bersiplcnoLiptngoebeddv.tehemfselrasoppmmilpnopmylbaeelsetvoo,seoPrdphyFpabObsvameSnraakbhnlselageassenna.bmdaeIsepncnholteimhdgoeehmftUeaeccsr.hStcie1i.ld,ad2lrr.8ieesn3ncoetuphynrepitcemebslsdel,oerhwuodamdhveievsloeeeifrnniuondmhciticchgaulehetpevegadreteilrnmoseensoerauaaflllnPtaspFP,noOFdwpOSugitlSehainntalieeorvmnael,elsanof wSppbrelaiaeedmssnemupsdmlpaienratoegebafcldoysteefdodvsiceseicrtvnraueiltrbrhrasueepltdiepwoctpnhiiblerdosorlfuiaofngPefghFeseOapegxieSnlcp.eiosteh,sIsenuwfrlrreiieolvdctmeoerbnsaaitroddvafsinae,uratinalaeynretsyydxepssofo,oifssuPhseriF.dctOeeErsSa(natfsdicwsoruhaogsmsseesnddeaoethiltun)ees.ctUtoleexndviiectielinstdytohSsfettauPptdFepiOsebsShr,aawhsnaghsvehiecohiwnalnsthoe NaSfintvoudedffaiueenrcstdehsseah.rohmSwaelefrttuhaymabetoaPrPlisFFsmaOOnSSdisilsseeuvxgwpegeleeslclsti-tenadab3.smorEeerbtaliienrmededionlimramatailiollnyenata3finMorodnmcdhhiatsehltfmre-ilbibicufoaetdle(yswt im-os,Jraskoilenofrlwsyl ,h4aina2nv8dtehdoebacesyceesurnru(safmopvlpialaronowtdxheietmdhueafrtoilenirvleyer. 4 years). Based on the pharmacokinetic data obtained from a 28-day oral study in male and tfheempalhearmmocnokkeiynse,tiac vpoalruammeetoerfsdwisterriebuntoiotend.(VJ of 0.19L/kg was reported; no sex differences in emPhstyoFrieaucOsirrnoSaLsnnhCouda5fdsn0esosauohnlsmof-iwa5rosr.nn2sitaeammyltl.iagon/dga1enrtidonatdterhaideatscnsuhkotaietsnitnboodexfeuircncaiebtrybempibtiosyc.rrttoehPdneF.uOocPlrSeaFilOwirnSoasuawtnneaeiwsgnaifvttohiiuvvnaoedrmianttoomuLbsuDeeta5mbg0oeilonndieflcy2imt5yiar'irrisrmttoauwgtdi'nkieggs.toinAtfhioevneeadAaNvamnbonadugdnscovm/euorketeorhegrrmxlaers/iodenizaapuagalsaiyseteitnigimoraecfnenonrsepser,dsaeaoitwnasshaftd,,bee-tiosdmdohgevoixehaaeseiprtr.cefkarilfhettooeAoydescrcsdaatode,slvbelhcetlwscoouyrersxanpleraesivovacruaessriheteicdlgyspystiiniopovsnisrentnitutrroesyastd,drf,etioaretpsbpounstrehxmudootyidwscnd,itciereethgPasyaeoatFtniihslooOnet.bnr1scSost.,lT5eeuicnhr-rhd3oovtaeee0lnvesd,s0dveetaiuimnbnenilnfaesdcgfilerReo/elnkecinahpftgcssesfi/,eoedsdswcunaadttsdayisrenus,o.mpcphlrltoiNeeheevntpymdoeikooraoerminenttyfoenoitrdlnzsnhoatyektagutsmhetdisceyadiaeaenslosalsid,sdvseuhirapnseerrrcvnypiolmaiauvfgltdasei2lc.atedendsTd.hse 1 A acabsonendy4so.h5unemdmppa3gtti/owokcgnee/e,ldlkeuasxlyaci.nretshAosyittvprdeeeorassttaremolsipevahnasytti,laootsnwi,1g0nlaasimbfi0ocg.ra7/ekn5dgt/mbrderagedy/auktcgoht/riidnobagney,sy,hoicnynypdsnoeo7armucwmtoievlegictkuhysso, liamentstaootxenirtkaore,elyahltseemvpeeeaxnlthsitci,baavitntaeddcdoudsoleeolasiwtzhaas.ftoilooondw prpwPgpitP1wnauuueF.oeit6nopppsoOsigiesstmnnStst))hrohugaa.gtwape.rtt/tiavckeodsloitRgrenvhoned/ceaesdcerovle0aeeahne.rypit1girdnnhgrsrdssomoihtgbohdueaaeglseuspnbnee/tcsdkoeftd,digrguiroeavoor/stlttdoestnaihteauohlgyetyypneoesrd.nxtiapddiheeinnoieTcdeerdvtiarhdetwteetyen0wilfwoi.otloNst4ienphiatxtuOmlilmhwnodaiAfewgynaonan/Esrdek4tidLsnasdgaptdile/ygrhdadavaenynyaoteafissyfdssflf.eioet,icaeccLparfArgtamOestlnrebtsodAetwrpitlurenhyeEbetpvtehcriaLsdertelt,tiwlewhvofrn0c.heoepo.rel1ipremyulAhoaet,raehsisrongcbetnetealddhatoodss.exwrse0eseiaec.dtceAs4toriutdltoelonllmyootndwas3fgofielr0gros/fessdk%oeldttlognohouogs/efeowdceberft1aaspsnii.vntetoue6iih,rgnnoprevaasnweoentmFixdeifdoonlforpfsnei3rfopppnts.socauru2ptuioflpphrnifrnmitssiegnbystpiggiotnrinsoi/dnintuk(nuytFegahgtd2dh'eyd2e(,-aFvI, oddcsaawDitonbeegeelucddsrnaverleoyidererfsavleaaieobncdslesspbeoadoomsnitotsit,fbrienseneran5ipefrltfiradtomaecehbulrtapogtabcteeeu/liitfdkatoigfbsogtneheaon/ac,tdddsdatayasdtminiyonnswdwsilaaniefeesgenisrsiksthedgeateatehclallsaryeotlbbestlnaoooadohdnldvwidgPryevsehFataspiuwesOrniogdrieaSr1ynrdittageiimodtfoodhsisungfctearis/asnaikdlninnwemgmptgdv/eridiieelrgnnsalaenisceiyrgsa.srotnetdteibaaaiSnerltfssseiiieoeogdcidrgsnnnaevnenP.svie.ntFedorlaiO.eAfontxpdSctAptrmeedredbvreoaenunensnsalroaeeotilrtasnspamlaglmoinantfdogdelie2dxentvv.seeit5citaelssaaillctmtoyoyietoepfogrdnsmaxt/th.kliuoeecgadsniS'ntisldtyieeiaogafsnlminvwscisianaeftoaluitrnicfitedehodatsyehnen,,avetrbwbiaedouteyevtrenee,t seaawlSTwvFPrifonoeexnsaeoFhaincrprcpirvtrOeusmglheiromeuramoorSaersadbhttcdaasuahleiaclaulssililreenleuanirecaoftehvyphest-ynrtniaeldeheausvyi-cvldpifetemgsenoiewevreoombioawtvetninoiboohndtnraeeahefxdaeutlgrleehuliyPcfetcnpxeerah,tumFiohispxtnetnevOiiemyaeotpooscetrcSstotainwemssiuhpsntmsrmtoraiouutouaaneanxo-edarolcnngyeiaitfytoldccsethseessksietai,deeunddeitpritcysoresonatebb.searnseraeaioiadaimeltnsnnsMrsdtyidaiecdoiytowwndnohlvtanhiohcueareehnmoateoenlmrtedhdnnlomoid.tetFtadbvhixmerlp0mtgleeeidDaiilmsrruircn-eemv,,tadsbigtuibetytmettaaiaadhonen.otsbliodedaseoeeeftttytsA.nhhsuoiepPileexdnflhnibmFeFtotytatuhyxslOeotreairahro,pnmrramydSomeupotlaeeniograshnetosxinleneuscheydafatdeirolmeinmnepp.smskdbokdioppiapxaltTonintlwoldvdaeeroewehwoeitpndid,twdehtdqeithrehrucswiwleuloeealiceasacnkalldoodlsuoptacyssarenignugr.eknsstlceepadtyoyetiest,rfeeDm,orhreionrsrroieneansartsteegrr.nptttifaitaasolaoseetwyltaroIolcacoifdnnuoodivetnptmieane-nhxnaaoslgacdsgeidaiygpneelssetadsaoutnrdibetnnisibnthlsfeytaedalgcdieruieProtfaanasainionFadntoetnalcirna,hiOrnnontesuprdotosdndtnrSahmorwtutsedeiaiphbpeseibiiunudldPnpeueemtlmscotFotavnii.fitiOedoeaetuoeshslonnsslntSslein.tynoiagfl. b II. Hazard Assessment Metabolism and Pharmacokinetics Absorption ha4cadaasPydtobo.iFr2gsmsn2ueOetot4sreisemrSunmptbnhliigottevoisiss/csdetoukrtacwrfagctldsorlte)aeyaionxalorcisltbncnnaatearodbipesbntdnsootl3seaoiu-loo.dt1rnu2sarnb4ot4.boc.ien%openoTd-dnrTnhfeaaaathuvstfettsooeesent24,nlertgdl48astadoragteowhithresialuoaote,itphnu5uafs3sergr%s.ro.srst4omi.95(inofnJ5%gAftot%htehththhsreoneet2eoifse44odofdt8nmhinohtg.ehh,soaeeeouGldsA.eurtoPiisfrbsvrFtS,aeespeOott.roohsmtSn,aesrTt-aeasah1mctdinoe4tnoledCfegtsamiatlesOnhesdestigbuasosorue9nesror5mse5a,uf%l%eowp1odcr9aaolfooiis7lsnkftf9oeeeartattxhlabhoa,ytec)selfs.orrctPedareoaTtbFirptigreaehoOrbeldeencosSscotdnfei-iasnrn1iv-orgs14teb1mise4Cs.ost5tsritnes5ynai(o-nv%mcs1lftettu4eeewcctotmaiiroesfoinatisnntchchtdtaaeeoatnlnahlfsdnydtteesedo,r2sa4es Distribution -rctwronmAoe0eaefetstet.rcaet2prac2helen%nea4setccsasirsa.totarnaioarrnvadtbydTiel4aoooyilh8toanyzfaeona-.ehc1cfdacdoatr4Troiruehefvnbhroodinicsnourtmoeybsnautnt,olo-frrot1aatgtiereoa4nstaecrldetn2oriiacene4ovc(lai1enseirtarail-yresbnnl2ebdgodod%otloelnbffe4w/l-tpasd8o1ooaasla4otarsmhvatdashocl)flmp.oeuoccldneruaeaoTosltnrlectsahsbdahenol.efoietnqito,rnnescufpar-teoti1nlPnhsae4tdssFetesruiOniahwcnenstaSeiagrdrof-selcar1pnedaotd4easmoaibrCsftcrslfaoe(i2it(nlJchno44ocuedtd.ehl2aoot2cnnslf4tmesadeotlorhhlgog4nsaeo/8ef,skausdFgGvnhruo)Codoriaseblu-ineupn.9srdmlos5iarTnn-a4sei1hst8mtas4hhe0,naheCro.dae2om.wwp5uOihposehrarbergospoenereoloxederncm,siaomto0iet1smr.eda93gsenotp79aexosaw9,nlceryasreew)ererd.a8ltea.eit6sosTc%Tnthihveoeef 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baaalinndettldimeomrwtihand,leiessibltriwyevoreedefrrfdoeyssp.PetrrFieLgnOarigtvoSeue(drpFd4:aaI2i)nldywdas4eey2rresadapasnryaiamoslryppztrloeieodsmrcfatoootrlilnmteghcaettaeipnndrdgef,srthoethnrmorcouetughoghehfimPngFiaettOisiatnalSgt.piopoTneph,ruiealoandFtd;iOofunrepemostuafolldte2so0FsbOedydaaayanrsniemifmpoarlalelslosswewn(iFetnOerged) 0(Dm.0og:se/kggr/odauyp) 0.1: 0.4: 1.6: 3.2: *samples not recAemmmmfffffmeeeeeiivvnaaaaammmmmeellllleeeeesraaaaadaelllll420eeeee1g1ru75.05eN008513m..25422..8PR204.F8(93*4uO0g7S/mclo)ne, mmmmmfffffAeeeeeaaaammmmamivllllnleeeeeeaaaaarllllll0e38eeeaei11v2g.4736N05e113.6e669.r884R105.P4.(708*uF1gO/gS) cone, 0Are.v0spe5re1ac1gt,iev6eP.l1Fy9O., S57c.o6n, caenndtr7a0ti.4onusgi/ng pinoothleed0l.i0v,e0r.1sa,m0.p4l,esanfdro1m.6FmI ga/nkigm/daalsy sdhoosretlygraofutpers,birth were Elimination 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oFroaulrsrtuepdoierstsooffraatcsu,taensdtuodnieesdoerfmPFalOaSndhaevyee birereitnatsiuobnmstiuttdeyd,oofnreabibnihtas.lation toxicity of rats, two wgtcimwpItiPsoennhdrFeseiioar.enttOaiietimggxuoagpSsThhpttcbrotietheouoooesrddesdutlrnwuesu,wyp.c2sdarshwote0est.Tohorn,i1eeunuhtar-Aadrsre2etroatelee9yildtWtt1arc9heel5rofslrettaro-oomgtritmadrsgsgnaSiaaehfinrdwtimdpnotomemsurueudeotaattrrupuiehngelandhsseusriitDyeosaen-dmxttutf-ahtyeisepDernyeeriserownidavdtt0tsgawiiheaeeaafmes(rldtlnstsepteeipePorrvtgldoeoicnFeoreuxnhtr.oOxrdhraptauTiraptaSotnnysponihos.i'gesdeescare5mouduatoixch/rutrsnpssoeettswaeoc..o,nltxey1sitaTnt/1raRu-hngow.hthr8adrrfleoedalot9e)osugrtdr,u.riywerrapaow2oDiet,na.nluser8xayiealrpr6y(pewectLt,evaorrhee1Caote4soer,xtulp.ae5rssf8pDr0ese)8fooiowa1a,le,.bs2fofydeRteas6wei1ldet2ug.air.4rt,r8sshrevf9feca9Doeroes,mhtsdroredat7oopoey121o.fvten040o4hf4ra5ar35ao,ldl.1m-.s.uaaD29f21br(yrip76.an31otnsoo3y.u9m.om9sTt7r.s1g7eIhgm9ih6,.n2be/)aldea4alltAeanitl.iPte0vsdedeisFast9lixmriutdfOgDspotduoigenoSntypararrhssyieol4esudtrpuotrb5re1erpeo.a4ire9otde.irh7rgady.Ithstt pBursloionvogiddhesdea.mmpTelhetehsoLwdCeorSe0f Locfoitl5cl.he2cfitmeeldgd/olannadDndWay9il51c%4oxfcrooonmn. fiadlelnscuervliivminitgs oanfi4m.4alasn, dbu6t.4anmalgy/slewsewreercealncoutlated TDe1x3hap.ey9ohs2mui.grgheA!.etsgTthrodhauoetspspeeowagiannrsoti,muaoplasn,losl4y5twe5.er9mra7enimniamalgstao/elld,snwesouatarrsulvysnievo(deDtdiuansyaenhd1de)ibnbLleoCtchoaSed0udLsseeaCtmeo50rpfmclaeaisnlmcawuetcileoahrtneai.ontniacskaelannpdarottbeterlemrmminindaautetridionnog.n The dorm8Ierb0nasys%ptehererraecmvilateai2olstv4iraeoto.ral0nryol9si.uotyntwmhT.deeghrrAh/eelbetrerra4exent.ppas8ooto8shirsen,itune2oardg.ler8ltdo6gotiht,rshobetaeusuenrerpdlbn,egaas1arnssol.8alcufl9earpsednsm,qiismasugchnea!hodnlawsttrghgiedeenedinre,etedhsyrwieageblalnlylsopsowDow2oo0eafrry%mtcoe,6aoxx.tnpe1icrd0oiiA%istatyulit,ora7ieannr.n.0ocgd5lurAuon0adubd%nipnndhsogm.er6me.o4amra9ntlaaomcliginiteagy-ntl/,iilioftehanle, rrreeegdwioans, ADtisnceoclororaptsiyo,nhoef hmeosltuncogmwmasonalsaobnoobrsmeravlietdy iwnacsodnitsrcoollroartastiaonndohfehreetolirveemr aanydnloutnbge. treatment 5 G rddoebiilsssaccetooerllvdooe.rrdTaa.tthiiooennrefoooffrttehh,eethlliuevnemgr,.oasAnt dsmigdoninsigcfiocalanonirmatttairolesnattahmnaedtnddtiiersdetleapntrteiedomnaabotnuforterhlmey,asldmietayclrlweiaanssteedvsatibrnyoeidnywgewdreeeiggarlhesteo,s of oddsvriImanuabootyslsssmaupseet.mesrsehvtndauoeIedittdsfadeyist0odseuf,foltrriyovre1nlOpi0padva0obreme,ir2ntodtel20oe/rr1k%tdrmotm5goti,thanabhd4claeoeo6etdsst4teiahyoig,nlnenlndawgesaan/eoncad8dinuifg0umtd1th%reh0aitwen.0olscg0re1Toaid4tglmmhhyheLdeigtnaoDs/rygkiafl5wogt0sssmu,etpPurwDrioFedxhneeOytoriatu.geauSnrcnheroseee.btdroyadAuafegl1st.ldela7lyr(v2da1ae-two92gxsD71eepe8r.2aoe)ylsegTugav7hrdraeeoemtal,ssntpsiahdnlwoneyiwdsDebtnrdeadeeeeyrgaceariiredlnd1oyd4mnpC.itstinhDeTnigeesihtdrsreoeta,meatfrasrfaat,sethttedes5ewrr/wai'esfsasotleelulrxrdwae/1ygsa4rsaolulp, mmAcggu//kktegg))o.,rfaelmLaDle50s v(2a7lu1es[2a0n0d-39659%] mcogn/kfigd)enacned lciommitbsiwneedremcaallecualnadtefdemfoarlemraaltess((225313 [[119690--331389]] mAiyinneluclltllchuoroeadwste2as-d,1si:t5naahnimtndyhepegldo/u4kanu6gcgr4togicvgaroionetnnudygip,te1adsd0leti0icero0erdnegm.apiosrgeen/md,kgsaltitomdumorbesaeltcyohg.nredo,Iiutsaptanespdnpdtaeiioetaadnrxsiabasne.idfgonAsrseitgontnhfesectooreoxfnpiidcrsiryotiyt,faottmihboeosnesstrotvuffardettyhiqo.eunegTsnlhaitnlrnyecdeluoualbdanseriedmr:vaelds wmISnhegeai/gkrsmhgeecaadonnn-bdWdelteoiwssrtesaaelrtnhsata2lunb0di0yn1,o5-03Gr00aa0tbmsrggi(er5/alkm/g(s1.es9x. 7/gI8tr;owcuaiptse)ddtewitnoerDmdeoiasnneesdeottfhaleP.,Fa1cOu9S7te8b)oyraagdlamvLiaDngi3es0tewinraewsdagttwreeroa.tgeTrrohtuehparsnatos5f0 All of the rats administered 1500 mg/kg died before the 14-dav observation period ended, with 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AAgsretaolfvlstoeetmrlarsol,o9einn0datknedneosaoyrtyiesntsxraieinolaaftttamrhtnareeecdant0tet.tm5morxeeemilnsactgiit,ste/.ykadgOswl/lediecsgarciyheoatnsngisdoor.eotnceuardplelayoss,cuecrdvaeisnicviroseenedarasuulelmndytiaadlcluktthriaivenliigtenynetdhwpeohassoftstunhpdoehytaestdataunsiddneyi.twnhcarSesliuegndnooesftdeotddhf.iearNmrheocenrako,epsysosyf.t In the rat subchronic study, Goldenthai et al. 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coacg--emwIf177nrhnysne9oe,g(teinn9rombims/m2eago8krta,rdudham)igsaesi3ldeee/lacosto,ddrylrcoliclyaw7,nthgnl2d'oy,ieeude.anaas11rsdu(yninvte-41cercsaima,oa/tmt2tllsee2leyanuo.er4da.rnseesnmxmled,i7sk/ags),igkfeienn2on4grasawye9sora-tnnsr.waeutpdaditetrohwpnaedeIseld)1lende,tm4ackaurPdta.ybosedhioFdrtonyysos2aaOdddBcernyd9iyouiShtg.llmnrioiceoaewidCtioditA-nnneniefdouasgd,diiictAtlsnegiesdisatomodahadeipfnontimmtrouisnsx.aeoruslgpptdianwaldallIe3tmaeestdaiess0ltssnsoaruipegexbppsddffleer-ollpayarhoaomssryeeccoomacisstocoendri.roeomdnvfsdrrclstiu0dalotdhvatAeymheynimn(crdest2eoetatp,en/P-ucmnmts7ldwedFtteaelrocoyslOyaxiibyrnlci,n/ogeoSfsekgidTofpuendreorwsscshtooydor.yocouteasemhnlpmyetaiSyhwtcnok)hafer,e2sinleeoomcyan90krsrnam.teb.dteprlwi0oeyanlpoH2mecegetselbitsheir.e,oa(nseeam3onceaonmlM/ahrn.sfifasvnn.ide(tlalwseaoiguixltvdvTtellrne/hyeooyegrharaayzgrefr,eutnerwoiwdtocdttdlumhaeeeiaxaeptksraflfioeset)oneesedsna,tmnrc.tscnkuoo,ddloadeoTderlraallylnvayleihe2cneslfecel.yddtca0li,tsnattesfeyitdodocdusraafdyly pacsploaslnnoecterrconeol,alslapenawcndtecearrdleelafctrsroo,emlafleetecmedtaeocgdrharoflaounbrpiompsnreawollmeiffroaeerrrreaPoxtiFwaoOm,nSticenesceltodlensnm,cueaicncnlrtderoaastrthciaoyonmnptiiucagsane.lanllyye:sviaasd.lrueaTnthiaoelsn,f.oelyAloe,wsakimnidgpnloeeyrgo, aflnilvsiverfe,rrolwmunags, cmoilNmilfvioanemecnrisrec,utorantosoelocfnsoohtetebphi,ssseite,ceosmroctovrrhoraipoentmimlako,nienictcychsrras,oyelsrbadocdsoioieeddopdtyefisccbmtwtieipmoefoaoinnutgrkhlehoaeotttyf,lihonspfeg.goryooshtlduifofidcernymordaniowtnsinnugaegsms,.epcanNentidldoolenndtt,heu.ysbcrtTol-oedrhxaeyerilrnatea.tenemwCtdiepegelreelfenrfpae,ntrcouwotrslateiefswses,tnre-ahrorteeetimolniannoatc,ettroedaedlsaoesmfignefyeedt,cahtiosesnurorltehenvdeeblsy cswdcsSH9B1hahl1o4ieoeommoo1sratwmewlehripemlegelmaslitveehdft/grsedeosle/tyrrsldhenfo,,mslerkatltoshstte.trahioemaayndlendeSsach6idyeemo2taoaarhrnlltuo2ymsmehdmn9loiee7rog.kfvhn/enepcfdeSamyeuohrlldeessrmoalsarlettltuittberhenhvumisdeeaeditmtraolteyhshycdrowceiohoovghn2eol2tafhak9hr.lllnt-e0ee.uyeedgysversloteoetsmeTetsessnlhrehdassgoiaanenl'tarftakdeheondnlrgareieeivtm/cnvmcrctdaoeheeraaltaaneeliuhylslvtatsesemrme.ssfgiodearoeTarlsrlrosnlpoeh2euttirw.ea-hn0epsdtremesmesrdmbtrloeuafaoaoterpgldytnhtulmep/hykamkad2eanegns9vdlyeh/dec.acdsffohlofradubHwoenoiyreanclmtooesesrtsdptwseoshah.ltpaleneietosenrvrdbwid2eoieiano.elrs0fcl,ddeerbwooolpvanimremtrensethreleregdesy-ola/utirvlkrfancosbeiagretrneaalias/uoidtststnmveenaaedealmsyevioarnnilyiipfgaedentlvbr,1e2eovsel5nt9seeuhal0t.s,rplaeuuimsintmethbhwgiioaogs/ttedhfhlnll-o.tto 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u(2n)s,ckhieddnuelyed(2s)a,clriivfeicr,eso;vparayire(2d),orpgaanncsrewase,retewsteisig(h2e),dasnedpathraytreolyid, a(2d)rewniatlh(2p)a,rabtrhayinro, iedp.iTdihdeymis cofhoovelalalorortnyw,,(iidl2neu)gu,omtdpieas,snnjeucujermuesna,wuse,meppri,editkiucdiiodytlanmlreeyciys,tsep(d(2r2o)f),so,teralsethoesi,pisohtrnoeaspcg,tauutlshmi,vo,eelroys,agellsyuiv:n(2agar),y,dmrfgeealnmamanulmdsr aw([2rmyi)t,ahgnalbodaorinbtndaue,,labmmrraea(isr2nre)o,njw,ctees,rcciguciaamtllilyc,bmlcnaepderhrdvveinexro.,,de, 13 sstrepamlcehienenaa,l,svuteerrisnnicualrmey (bw2l)ia,tdhsdkbeeorl,neuetatlmermaursur,oscwalne,ds(ttvohamigghainc)a,h.,skteins,tissp(i2n)a,lthcoyrmdu(sc,etrhvyicraoli,dth(2o)rawciitch, apnardatlhuymrboaidr),, ce00oMloon,.f7nand0t5glht.ero0eeosm3rflr,w2goea60b/cenk.ovi1dgwgvi5o/heetduheeraasyedkny.sd0p3t.oer.703erf5.i-a7ot3t5rmdm.e4,amgetdk/nmgkigtf/gefkgae/ngdrnrto/ea,ddunymapfcyefseaemlstrmereasieasnlaeplwteswemecwteiertgiieengvhaitheegttlgmdhyrbe.eo3ednu.Ft7twp2e,gs.me83rer-o.an8e2lu,se.p9tps3hse.ekw5cwgt,ceiaovaiasgnnethltdstyrehto.ad3elt.Ti33absht.ne1kiegdc,giadn3tlfirln.foey1fira,entstrge3hiegd.en1oncaf0iaenf,tnihibc0dmeae.0na2tsw3lt.ts8.u,edA0weky.ngt1e.rt5tfhAehoeaetrnneottdhhneed dTdphmweiuywaeatppsldeoeiorlcmasamow,fcltiatapdenilsvareetlidssdoetayoftctg,osrhruoileinabmmfgibetcosoteop,uhrdnucefeelhdimDw0n.r.a,oA7eayns5mnmpa1umireor5ycnarg5oltin/aibik(oderuWgg,ncn/re,ldedoiddeaqsckeyuilsoihiv2dgnywe3rddaro)iir.ntutwahidpCtoaisnolbsdei.nnlivdad,Cieeccarlntkaeinelon-cdcatistcoceirsaglueduolntcrrebssuveiymidignvnnopebffstaleeeatlcnondpmetoastimphtt,neioeoaldtosnthsiiw.itocinishnCocfea.noladun.oOuudidsImnelneedcaddaooladlfnsoyidnasdwiucce1trimla7fouitof9dnphio,ce,tdiwetdoth.h:aneeOsc,soanennecsiomatnrniadiclmteadl wcoanssnuomtpdteiotenr,meixnceeds.sive salivation, labored respiration, hypoactivity and ataxia. Cause of death Mdfeumarilanelsgesatrniednattfmheemen0atl..1es5Thianentdehfe0f.e07c.5t75omnmgt/ogkt/gak/lgd/cadhyaoyglerdsootuespreos-lghrwaodausplorhewvaederrslhoeiwdghewrditteohntisanilt5ychwloipeleeoskptsreorooteflirnaenccdohvomelreaysl'eteasrnoadnl dthe effect on high density lipoprotein cholesterol was reversed within 9 weeks of recovery. ttvtatEooihhrhnnnafeseeesdltavtusdrastheaadeeaenodrsidyxdicdriasuoiwmefftnsalei9feooloem1ivrnnnrtemaeaeaalonlwsanupednictdesghpuaelsyniterso1caiaiwnt.8hftwryhi2ecdhteerooaaireondneyfrbatlsmbmloenyyowo3oart7t1endhlee,8lceirafsm2o6ftiv2neeanavadrnslalaemeidulsnntsuoetadtfeeslaeetnfn9mhrwist1dnoeaaogmtlbsfavireevdueessmtematrhinggteaateiinilgndv0meciai.esfos7igeinnntc5urrtoaoasr1bnmretuo0eitdplbo..cgs1sena./iE5ktnuwTwosgsattrfeee/hrnidroeteideohaonneyfsde0dtsvo.uitoe7vfeatdnxf5ahsreyeltiydruamsremca,teoinoygswoantms'tnkiweefng6prrreieoei2/lnradim,evclnat.a9haovgtt1leAte.heu,snocdepTalessapthenerhtaawedaaerrorleellne1fiyynrno8ecwttnd2hoedneeoinrigbropsfteouhtefrraefote-eobrrltrtbteesahlheyiinteneabiccsortlaueeteonuhtsdwseoeienfr wwAlivteeeiitggreshhrmttw,pielneiravrecleeors-nbattcsoaer-gibrfevoiscededyw,iefwnereemtwiiganohlcethrsepigaienshrec-tddheneoitsn0ae.gt7hme5esa,mhlaeignsg/dhak-ngldid/vodesianerv-togodnr-ooebsurehpa-iiggncrhoow-mudepopisagherhaetfddermaitnotiacoltrehse,.eaOiscneofdnmthtaarebolesltsosw.,luol"tivemMelaroi-lvtetteoslrebndoo"dt y dsthChuiiefegrfnvhuhti-srivdigeilohnohs-gbeedupoumlasnateartoillocgeersrthold(leuuiinpflsfac.curlhsuheeddyihnupegleeprdtathrtootoepcsrehemlyltihunwalaathlridscviahdaccrwnuifoaoitsclaesatu,ilrosovonnievooebhcscatoeudrrsvarcee"hddmeiidnnout2altelleldodhfs"i4agachfnre-idmfdioclaaselree)gshefeaamlndivdacele2re.nso.tTrfihl4roebmeuaollaefrs4oirn NsaocrPifFicOeSinrdeliactaetidnglesthioantsthweeerfefeocbtssesreveend aetittheermr minaaclrsoasccroifpiiccealmlyayorbme ircervoesrcsoibpliec.ally at recovery Developmental Toxicity Tanhdreoenperestnuadtyalidnervaeblboiptsm. ental toxicity studies of PFOS have been conducted, two studies in rats aeatgsTtsmhouanxdrhexgocbdajeuir/smjnckiesnsffiugctiiuitnenrmcyt/mseddeee.tdbcaddbasryeIectotofnrourcopPndodorosaFiyfrGyvvfOdsc.iiDaikdiosSmndeucArgml2peapiepn0rlolttiapaoanrbclbnarliooobytsaeadlmtxobuxectyidnitraemoeoyeomwranidvarl,wmeitisnefcbinieogalaatyuiyeulhtlgmiisgrtthdoo.siabgetnin.vswesrFelaouro-eeDbgustoctrhyieupaeanfimsstrfgovreidreonosiseaacnofelwgwboi-2faezlrhee2edtnsaarhrterdeenaateidinndtmmtwifdhooesreeeonneten-iundcogmoGdsi.tvhtneiaaoDoaes-ytrrnvdesewi3iidedana(,esbGngS,ro6l.dep,Dneurt9sfT)fGaeei,exhrg6xDti1eeu-ue21daesdr,35n-eeiD-das1nm2(,n5aG0cBad,nwoiouafonnslornmueuittrndenyibbnngcej2er'letria0ssrf,cnte.tsoswi1teocuf9Ad0eals8ru,rlenet0etos1issi)moio.e,weg5xnraxnpD,ealtsatrsmeaoienroonswidnndenfaeselsr1deiw0tefesor,re rmS1e2ipgg-o/n2kr0sgteo/addtf.amtyhUeaftnohedrriegnmrhaal-thdtteeoorxsnceiaoclngittdryooixtuciipoocnniotssyfiso1wtfe0edthmreeogfis/ntksudiggdi/cnydai,atfeyaicd.Na.nNOtoAreoEdtLhuecortifosi5ngsnmisngo/mkfgme/adanateybronadanyldtwaoxeLiiOcgihAtytsEwLdeuroreifng10GD dbaaagaeoDiinmppynneerrecoepddpvbpvliu,eeeodolettpaaalwcohetlosrrnhoanteehap;atlprcdnaiimllehemczetcfofishenteeooeoewdsnsrotnnweuetbefttawssaoaesvltuesilehwetatsntrerehtno,naeo,osseoxsbs,extaptishuacsicrriescertirofiefgeeiestitrsftyeeaenshpyeedntieconoosf,eitrtikbinfdsvcaanewsitaisdwflhedlcsnefiueeryoeteettvvhtalnrmnreeyeeielettamndnlerv,hoanotcbtatirripolhengeirsrmtc1sayis.haa0atcooeewltloTrnllir,mnoopenahdtbicrntgslneoieoiais/oplsdkttfpennieahwegonrtorerho/nsgtesetdieipr.hrtdtasneoeoeiptyug,uAsratarotchptailcicaimlsonssoebncdodntuaenodciocrsosrosmotyt,daibernhsflieaisstlenlsgfaelyeeisgetsrtdmrnhimtotvsnsueotuoeieogsdegufapdfeningtn.sbosrhtihite-effneenwrAidrmeaacuscauillbamtlouavecfhnntnotbtaebtehoitryr.troedrorhimaeoernm.ereIstlsisnayna,Tlwobfeilgaentohinfnehdttefoitsvuritdeheshrimsmiaseameetaobbiosooeobabmnlrmsfennlaspotietet,othrbmhanirmrtuoerevnhmoyanlsaeetollonuaaldeeaginsulsb,nptiiauayimltcspfnmeyaleaebilomlalesnaleefylirlagnrroetalhsnhdndoeteioee,fgotsohfe detnhseuetvcaleabelbluoinsspoh.mremSden.eactlaoelnmtdoabxrriyycoiltneynaols fnfiu1bcemlregud/sek.vge/Udlonapydmewreatnhsteipncrdooingcdraeittseisdoe;ndsanodoefrvtmheelaolslpytmuedexync,teaapl LtNOimOAAmEEeLdLifaoctoreluyldsunrortoubending 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oNcoeawmndpttE1hrrnxb0buouveoaeugdpsmsrsasism/ieetdosgtkntubm1srri.esrggggvrvi0eaungeS//eneervdkrc,anmniddieiegaagnfiadtyingf-/ndpoanocdir.d/itucenoeakfaffrattlrniogypHemihaGcenotl/rlteaxltdaidDieaddolgnnicayotd5aiwhteee(yfs,1Gr-fmsaldeinwdeo7bnidneDnra-gowelgodcee2oclnrsrsine0ooeteget1te1rrcoduah60eomiaexgwypsnt-anfssme2irethciotviswm0awmhwmigeua)nteeine/.yegpeanpkrn1rb,risleclgeSnse0tm.aoto/ahifnadodalmmgeolTaontlybaanaustdhwdgpysnotinwiew/eiafesckdoidrbreecrcamogvneooxihdsandi/egsdehnndaessdeohayiiraatwibtabtgnddygeidlwiisengelsrttegeo,doheraectprraendouiurivarnrmcdegspetveeGoaseaehasgoitdnnrt.dotsDweningtenagdiragrbueTsnoteoan1retgchlttiu7eeicssrhnrnret.rpyet.eoresgisa,aeamnueUrirTdt5asnaeeapeeeutrnnhsatsdmaawede,rdedt,nnidseaaeenewi,drmuonnlnrtigonocngtidcte1thtpt-uthihGhai0arGadecmoteenlnDecosmnDlibnciifanntscagoegoetc6to,7entrrow/ren-homnk-di8rddo1feelogti,,iiirn6rfcuc/tngco6e1dioacgagrooal-0annoocsh1lannnyotusrm6ssdsdbphunpt,didourgsoamo0sseoaodrt/ir.i-fceinrkidsyap2nncdrtedgeTt0hegotliw/reuaeoogwda0eitsstenrtfa-dnheoste,oi2yihteagswnuabut0d,uohnapdpodaeanatwldsoottyrbsmnchess,lee5hdbbmeestrtaeoslehaoigiidtnennohoardunold5tssshuyo1.ep0 NOAEL of l mg/kg/day and a LOAEL of 5 mg/kg;day for maternal toxicity were indicated. oscoaSipwewSlnatonfsekfiuetedfgsmoreeedlriiicnimgelccfytpeersithate,nctoaeasttasoarltrebasoliswetfdseoiNrdfve.osdcepofarOornettrmvoeriovnoiAebofaeatsn4doatftlElth4sioeitatonhLi,e%pthnniiftemsnmecosotttglihstiefuenaacikennflslfa1uetcetehltarsolsmltphleiylun,gaaeswgstthlnopsreoa/ariodreksxitgdspbeclginosfwt,tsc5/ie.osidios2ifmeatrtauiny%aSnhcyagbsldta,l,iracvnegnaoutsni5snticisutltr4usdlceyadpwtu%memnildacerdeoe,baaeer,ioLfeelfdloarulfrOnr1aiyeosbaa0dnorAbeseeodfcms6iEndmoagwed0tegLgsrne%eamve/eafirklf-re,odieaorigedffcev,m/soafalde5,aeilarnnrastntcdtmtou1veedoet,sd.bihgnloen5caer/tsbctT,akryrr,ysr5olgaeeheeaplncnd/eaasrndtoddsvn.sodaoeleedruyst1sdScofsim0he.ni1wifigtf0inocnmaisanUrlcl,mmturigahdndfpld/tieogedkeiecaaso/velsgdakisnvnernn/,giwdl,eccttioa/hxnaidealdpdyegtctlaneehmelr,iydrccrneoanrdeoracusdseeanlsnekgseoladtesdpe,hassdeaileele,aitlenncisanitntgdontoyaditoirnclvxhsnovnisleeivdiuieicmslmnoaepyincotrnesf,ebuysi.facartksmhnaett.weihTelbloofeeeheenrsfterteaseall Tttnwhroheeetaerectomdobtenhesvteenrertolvs-ovraeepemdlrmaseity.neendtsFthuaibenrlurdeo1tiy9unteh8ng3edsanibdonnlegfaovtarteebhmrlneoassopulermigtmfigeeianenslsdtiatttiheilnedagtstosaiwxsnaiencberideyetyientshgesdeteeuanmvdretyiainlftoatetepcvhrmteesinespontrcfhteusovwreuircoeegtrunhieostlntyishniteniuutgdinsa.tydluTledy(rhGyertohedAvroetiunsgeigeewgrhnn,.tcy1ato9ni8dsb0ead)wowsaeersereof goArpCweeofhecsds0irottgoi,a-rshsttd0trietie.oesa1d.anvn,tomd1T1eluat.hhe0ymaeno,sltue.2d0r.p(o5o1epeaf9rrsonii59ordow9dmr36ae.tJ()-r7oLi2e5.ae/9akod.;mngbmgdfsgwoeie/nasokraftidvsgasteett/caeirddoodradenntmyowdsdsiuPinpiacmnFiyresgeOsptgdetdS2nairuoe0ialinrd-nyni2,ntw90fagNo).ad5.retsj%huwvMresietaTZcteabrodwteeierlaaredidltnteaemayanndi,lle-dy8andbn0Watoodidnplbhyyecytirlhttiiweghnoeaeridrbcoviagaaaubalhsnggbitdeohisstbosooow,sunnfet2ecrir2gtenvehedapedsrtietaievsaoricittlnduoigyosudrrdnadoywleuu.dedprbariO,oneyoddngsnyo7tsh-ee2s0. puegaeteerlsrlvtyiaictwaionvednris.ecdlaeeatxryeaa2mrwe9isa,nosterhcpdeotifndoodonruesns.cutwemTdehbreaeenrfedeautntuthhdseaednsniisuwztmeredirbb;eueartwigooernfiogcsohosefrdnpim,eocsrpareloxalpenusdttyaeataionoifdnntsehe,xealacitmvhheoionravaenacddriycfd,owearabaedsdxoftreeemrtcunionsarealdsle,daan.nddThe aobnneo-hrmalafloitfieths.e fAeltlusfeestuwseesrewferreee-ehxaanmdincreodssfo-srevcitsiocenreadl aanndd eskxealmetianledabinnosrimtua.lities and the brain of Iacgfnedoetnsmuattsdariendotisiilos.twinto0een.dr1re,ae,dya1rtes2.h0am1e.t,eo2sblva.l5limeotdeoaendsaddtnusoda3dsm.eye7sxp5walaemamsssiignnwc/eoketdhngree/dfduocmacroytaleelmgxedrtceositnreutnudpwad,sly,ha.ainrcbedhTnsphtopheerrecmentgliauivnvlmeiaetlinrbyete.wsr.NaToesFhfwewedtoZuediesoegesaehsslweaadwnandsedarn3Wepd.le5aasu.icette3echn,tairto3naanbeiazebnewdiddt.esr5bTwenihenerethe 17 pnootolaevdaiplaebr lleittaetr.theAltlimsaemopflOesPwPTer'es sreevnitetwo tohfethSepodnatsao.r (3M) tor analysis and final reports were a2app(swdt7gsmMmrginni4ee-aeeggea2/gddrra,ysaknrntii9/ttseaetookgaeit2i)msfhrfddgtr./11ainiidnece/wcol-0awadiasTan2annN-loyelan1nt4ahl)byOttd3ts,tlepnhloo,aryweaAaigoeaxdenyssrlr1taiEyrcisseoc1w3soewtordLui.h-2dwed0tas1epey2asu,isil6ewn(igs-lc2egaid,w2eanegan.onana85id1sahsstndiyifins6iftieraas0gific-nengncone.t1na1a7hiavardd9nntitn-enrifihte2tmndedi3whatleci1lyase.nedngytae7)tn3hdoc/,wmrn5rekt.reriee7tpndee2egesadm5ocertrde1/ntuieedoisnu-rgtnmddcdt2aencc/s-epoouy4kseetitgsdeserhgci..gd/tdeerostenku/iiisaedfMnoioigdit3nrfandomnys/ei.tdyecc7.tfhdtaheapaai5hengn1ynenTnete.rr2trmtt0hm2eobgli.1pyeof5a.uorgme.5eedto0pd'acmLrrkmugsyenmeia(Og.op/edsdgnk/wmd.nguadAdkgoiMtyckneaa-g/(nEe2sdigrdyte/gtLdee.agadah'57dhrlayyneeaani-tfabsnsm2tyoaa3ybeotg9lra2ntd.orgag)7ht1tdgbm.diiker5enbo-rooydga2aosynMd3um.bt9u'wyde.pwtod7)pegrhaAev5a.anweo'eayikyeniragnnleem.gMsslhdgifta/ggauttgord1Oeboedohldo/ga3asosxkunutydoyn-atrigrep1agitcanc/ai6cstfgaidotdiouot,a,iiroyoanfonootlnronhcy1esndeuswrud6osupdogiu-clorptanm.aa1hcsrorsfeyot.c9eitncpentShsuu,1htsdtegTecpiri.ue1v0n1orahfme92t6etonnsoehimd-.l-nttr5rpr2ey1ueweg1tof.t9dgiteh/anso,rwyekceasteMnseug1naa(tsd9/saddtedm-ytaaa2ai2ynoe1y1snn-t gctsrDreioregedoranvuputieecopfldtisroica,opaaanlmnnndtitdelneyncaatto,rhanesrleidtegrtsouoonoscxlirsefipgiidcfctriiioatcioynnuantptwtsihsro,.aeenlsdi2Mvuoe.ec5vfe/tidtaidahoenneenadnfdsetitn3tefaa.er7ttlnth5dubuesoommeosdsesgy,(ss/lilkwiofitgtitftece/eiad2rrgt.a5iahsyovitznmeg(ermrogaoa/gfaunkeltpdeghss,'e)ds.feaihenxTyymhotrahaaeinledtreideo2(al.aw5niwbtdatoeaesrvnsreaeedalx.csv3eooeTs.m7rahac5pegosaemimngrsaun)gbb,mi'ikflnmeibgecee/daadtrn)maaotcywoafnargpsals (tolirttdeervaevleorpamgeesn)taalndtopxuicbiitsy(wlitatser2.a5ndmfge'tkagl/advaeyraagneds)thien NthOeA3.E7L5 mwags'k1g.'0damyggkrgo'udpa.y.The LOAEL Reproductive Toxicity Aogr33ine5.ne2psettrwrhtaaodmeottdasi-goouygp/fnckefbet,sngirepvpe/fsdreaoreiaarrnxftetyguuiop,rnsfineaocwtrcirtoriardeosinsofipn,xicsrcaoeoiewnndngd(eudaaredcuolpktaucupisctlvprettpeoadawrxttniiioiooeinmxrmnrei.aStcaotapiletdsrlayaymnagsdni2utndu2edid-soudDytnrea,iarnyddwesgedelvstemoiPeygtlaFaontrOlipea)n;dtmSgsf.etbe(onCymTtthaeagrlresla,ietasvlttfraemioaaagrtnreesnnthewiatne:teigadntr,hoeoma,xstneira1cdsel9eaeo9rtfee9rffapdbe0tr)cs.to.th0scdr.Fouo1onic.ufvttg0eiiPnvh.F4gueoO,reueodS1tfuf.6upeo,nscnttaosinlfd F0 Generation: Parental animals (F0) were observed twice daily for clinical signs. Body weights and food 11 adtaew5opdnlcdsrrwcgcdsl1haieavnxuiaoroueo0aefuteceesffnoatcdracmnsmrnrelptietsifaditirmietrgrgasmseaorlnanaindsoipoxaithuhfcbrctgigsidipwarim.bfitemneeowsotuciiouslleddstvaetnmneeltleiPrenrphrde.yis.deeeiiiroateuddrabitdgaceidneainonTdctpafEout.hro2iavttoduafyeionhnsthtfvntyolarim1ivlheTptegeaonall(hof-cmavev(es(uhLlndnsgenlGoFslaiuiadiaeaaaumaetDaenln0waitorcyDflLlduabctmedtFesyei)ptofteei.orgDid)taf0lzeollserrs2cltarnetiafedietehnai1tPao1cndcomn2odyowxetstt0trrtae1suften..n,afaipesaaeo.llroonratnseeglotpartrfiddnBTnhefoietmadonotErifoacadiinsshaenlawrosrwanyrclainotpnmeanilepndciolhenoyrpetataecuschheews1laFciirdseiyofltcc)lvdmlautra0eere.iiwderehaoerisiucnvnacmsdeoosmlvapgee,rttTdefrnewdsdaemiaaaorsesrwudainhaederdlietliflmn.cumuepgsigegeldaoadneiwsodssfalensiiupvwbreactlognkt.vsereayletwsecrlegregaiiheisutredrrtndfarsOin,aetakawfhicd,eooeteusofdtntleoaoCmevunsaitmeyrcrayctirddnc,aitprnaicodalnieesoeorfoledeyoeanlyiediepgtclnnpuazesestonicidmfhoulfaeni,vsriiopoaip.psiydrinrrtsaearnaneln.yamauewasiismlllrndnTdtrg'lneiyaepei,eLletcTadsiycsndhesysdusnnraattatith.md-e.eierhosglneectpsowbei,hTd;etdcnd,teiulsyenaaDideitrhcilfoaptxovthtogilfrmeiiertoCucvanaonreeefinpesdvoorocfmneraoa,rassteidaomtiurnlewnrem,itfaalpdisnevepmmsiirsgnrbtbonarvdttdoaahiae5feeioiyeooagetrrmtcrslodsrislhniaoiinder.umnmeelentt2eeftmsaoyyalgtnaseit1ddttasnTigtnepss;aga2n.elawaw-ryeghetrcotn,yeatst1hothrheheetOefadlbs-iearwpbhfeiirodcta,oognfsrneeiuuptatedpt1erevhdrhfaispra,ytrgmuemeoeleaenhtergsai4srsntpsxnlesn.dalhoeca,pl,aedseawnanylstaiunmowmee7mcnatnoPttefapoadn,mattuwtireuirnaarilihnfstonrenorapw1iiittbeaeagsermdanheoit0enrloaridssalooecyn,ednay.tsarnfsldbss,nvtgaaoemc1unwhsieafstddecmOpras4ndauoseseyabisaron,e;cgefrmnraaitwiserdsiwrUfveacd4laeicthiieiaeberndlhao,rnfcteeatedtsertisiedtedherdrldenvescimaetriied,eoruheitgtnanswtwtonaanondtehthednuohnnrostveerteoem,inedtdiosfeerfliatnremnkdbcGowgl,ehmeyDerre FI Generation: aagTdswSgLasvroriDwesocnoosrirucueeigei3denpspfn4ieatseco,Fybvn,def-emiaco.fgle0tinugaoav,Allaepneye0itnatne.oreFr1t2ddahanr,I4idatevisatiLgndiign0wdoeDa.dma1nunyeeaw.s09raprle.0naao4uO.httedpfeionmvoaFr0uva-nggLe.fsli4e/uamiiDrkl,nbaalmgageoitt2lels/dngied8dfteps/oya,Mkeyrfrwfgorwae-t/brimthmsdateeehtpasahaxgvezlreseireeenpivdsgamsneioogendriwansxeniediefegnniLooprccgdesfeDoaereernnpoerotl7rvugLlioef0ayptrpDtfo.lmseuuurtrheaawtA2piedtita2neiesuwnlrsddaceegiseongeaferseddnowcepiahrnmaecriagnrtrnoddehaeennomptethidttsceoiieaeorntnnigionnuoig.1esstidcr.otni6ooOeo.dgurhfteanehpnravtedeehbdawdrrigsPaot3eamatFtu.csot2OgpiaootbihenemSnersdptgtsbahawe/geyttledecxeitGngngdhip/nceaaDideynyrvaaara0vteabgplianeioaeadtcdfnntsooheasd.sorrtieedvnoese TdinehlteihveFerIFe0gdeglnietentreearrtsaiotwinoenmre. aslAealclrraiFtfsiIcwegdeenraeenrsdaatcnioreincfircfoeepmdsiaaelfdetseorwnmeLraeDtina2gll1,o.wneAecdlrlotFop2sdiegedelinvaeenrrdantieaovtnualrpuauallptyes.dwDaesaremdesscthriabted spaucprsi.ficed, necropsied, and examined on LD 2l as previously described for the Fi generation ngmrp3awmientur.e2egloormtatihi/ruhgtoktebimpeahdvgelth.e/giFtsrdteiO/ygasfokFoo,thygfofgeoae/dmletdddlnshn.ooatdaeecwysldRroeesnaoinsedeontsgmpsiogeworeuosoinfmegimrnfuttrheaempgpaocldstrtubtaiio.vsnoprleueoegnfoTpsowf,nriseeafcafn.crtltmo3mtsetso.lS,sh2aiidvinettig(hinmeawncnecr1loggsrli.a6nuetb/htookdsoawrgu3fedfn./mdolrey2dduernaiperpwm3deytar.)indeon2goaoiuday/ngnkmcnuhtdogtdrwcitge/fostida'itaknntvhsawthcgsmeeyelse/uideiptrndfgodenareonxoeytbras-iidstocfelritdsileitascitohoglttyiaaeysgr'sbnt.oeneiioptungidlgAdafypnritryccioharwfslaeuemiiwincngadpFaesetinusOcntiircegaadfteerllihlgudsyscdteosruanieigrincngnrveeattegndriaipotasniluhntuotnshceiocarsoeetarft0nedeeinpt.ndado4drmi.sxn.eteihi-ainanctmelinheinaatdeaasnybbtty,ihsw11snoe.n.o6de6glolruouaetstneeesdeaennd aavlmGIannniDcaaddttbthail3fn1eteei.0go2rFotnfOpirmol;eirntgrgayoiCen/oknndpadg-eaevr/rrasdeiaaanadatmrdbiuyeolecacendttnoeioefo-nressmsntemei,snbcgtaurthiirlynioeeononubgsrnipoa.unttsdmsghTy,a,rbhonnwteeuhodreegsodiirhnngeeoolchafydulttuchitadfdosignenrnedwpddsooietftnlaroroagateocipsodalrpunelricetepzeoaapoeanrnorddsatrteoutnaedlmdladbocaeppititmtaneaiatconpintioynhlayanevend.dFfatuofaOlresutiicenedotsgsanlemsoopv,bnsreoeslo.ree-mscrivtIcnrnaeuottdriduhnraesedgmduc,nrysugiincnmeslgsaitbtnhcaetegrhtrii,ef0ooim.ncp4fe,ar,detai1nno.d6gn, drdg0wotbdwRotoheory.ebofea4hdeofvsssssvsriutueeeeucehmpecpsrlrherrggoveefswgisradernpatei/oo(ehcnbktgmn0uiruieegl.done,eiprep/nnred0nstoTtidohrg.attpfw1haeohevfheoln,tenee.ta0hrsf.10riy.eaLi01eo.t.Se6sbh4T.dDo4niniem,mhim,lbtosniamesathgdignyr3ecrslo/eeg/adekru-okwlt1vr/fgroauwgkl0v1aeey/rs/gd.teivsexdts6iv(/iuasreodadceipsyarrmnnyaefe,nosnyaglegadtnpaadocann/lygseopekrlpderdsrtuswghiolssreepoeo/iiuyuildngsdwtnagrsphrahvylirerte.yvrctohiesftreva)lheuemwAsaeloiepphnx3asabtstd.oagesr.ieste2daanneheNvsnpnsisnreimpneideusvogguglisfepenogenotpensdhinpifskrfifdneoltfmiigpioencrnocpda'icaefdnofbuetftnntuhpanslnhiplttalerhyaaesslitoyyytwcthynr1uawdtsei(ea.dbnioc6orettrcteiofhtseinrlaoiolomeeieoaltbalonLsynydgsgisdebDreiier('etsnmkrodLrorrveegegviuD1siregifs/alpvp6nlldahauteoeo2inratrowtxodpnf1dyhnwtenamseo)eliscee,)rdeyn.eeey.croa1)wneoeti.sorhB6ltieneinbboegrytlaaoeprsighctvFnoethetrtrhoehdlrIoneosvbieuisn.psg3eansspieu.edebggd2Tnpnarin.hovlodhslemiialsenetfrAedioyiaddgncLttflog/tiaittikhmaDsoohtrnnhgieoeonlteea/tulu1adhgdyipo,grbaerosofahiyrsllfuiei<ogttpeywhsrt, ThmA1i.hs6ggeh'akmemgrsge/to/dsksduatgolyt/ss,diedgtaohnvgseirefdoivoucgiaspareonbs.utiglpifrTtioyn4hud5eipin%n,rdgeweodxriuftehcwtphtoioaeorsvtnpeegsudrrpei2nisan6t%pwltyuhepeorreefovdtfifuhafosbceupeinplrdidiutnyipdgnsebtwaefhdogaeuassonnentdhdtLoadotDesaoeapidfpg;rernbeoaoedrutuwppocusneeped(Lsn0pD%sLuupD4ravtvpi23vio-a.e4s2bdt.cimlubiItinegylyi/tnkoahggtne/dtdih3nae.L2vtDthweoi . 19 JLO cacaalw1elaonn.sve6nddnorencedl6toiohoban6bmessao%sersltieeiotzgranacavarnutiloetastriu1dostore.pi6ennadw.dtgmouawItfschongitepr/taiahkuowtdgspwnridh/segdoioidtnnatiuhhiyohflcai)naiigtt.tcd,ithaowegTennrneesothssrsteierteizdeanvelsodtaii.tpsuodiceluctnelSaptbngittlooacirevoortenniinnusagoitpbnotiifhsncirl.tmadihwftleoyeliOxyaluksntanhwsnuidseindmagirgsdntbmnaehiaedfiaelafirvdscitsoce.eoatarrnofsnsntmieiatgmlrlaynsepcciidgfhalruianer,ccnedsaattuinsaiiocnnttwnelicyotdslhenuleriidlennse3daidptt.sue2hucsemlpeimtfdhatboegtioelgr('lks9rdhon4gy-wwa.d'6dlewiot%adhseye)ibpgdyguihnorptaossstuehwptehearte gSrionucepsF,Iongleynethraeti0o.n1apnudp 0v.i4abmilgit/ykgw/daasysidgonsieficgarnotulypsrewdeurceecdarinriethdein1t.o6 tahneds3e.c2onmdg/gkegn/edraaytiodno.se ptrtvrbC1eheeyaa-slpel8rliatunpaoitfosemiereo,ctcsrdleaecfsldofloteudeorwmroeerrmrasbfiiil;ftnnnsaeheegnganacsrlcretvapnsewcvatairenwteriotinsahrgoseieme,ccnareolrsse0epepht.ss1paeiio,nicsrogrssartrtn:eii-nthgvietxdebfehedaiortcmF0madaae.Ivny4inpnordgtiewmaidedrttnieeneigadoondie/nygnkturscimhasgtcoe;att/tniisdtisooaio/,a,sbnbrnyltoosoiswmcodrndaailygpaonulcll-rsetwyetaoeerebsmerrsoltsaimeiaargogtvtszhlenreuere;tailetflspepgtaai.ecpenatnfiaeridvontfnaieoostotre,drenwdmrdamcievofaouifierngnennrcrhrsaareeeuetlgssnmmeppbcfaooaepdorndrstarakisyyodwtaehnibwogeeilnrfmoeeerhpi.ni;ggirrbhpeeNmhitppotstoauosi.ootttritwrintnrTaeelgeldhaeaasftesonmtfereoiopnevrnfangealartyrlan-utdtiyaailoitytoenysdf; rdrwCtsrhaeeialgatetpyieetnnossen0iir;rf.tct4m1iieaaoc-dnl8aamndznofpgoetbono/rrslkpesoergacteerswnrr/vssdofyeepaoassatorcoyinmnooifinsndpnateoshingbcseciofenaeoedfnhxrogypdialrtbalohwmodireutawueiipnodirFigianinIinghtngigmatgcospolenl;uananesdmcrv.eaeLtaraamdaDlttu,tiieinosaortgnteene1.drd-asuf4n:Tec,bdmhtyavienofaaprednlleereustsrseiwfiliswoignetrnyfremboeirfopreaindaclnolyeraicaakneswmrettnawieerinteintiigesdsgahrteu,isptcc;ss'auathgislonoolsenrynirsevtstmd-saetaiiteagnyiarronvkmfniloaofbiiopircdnledoeaadts.nencetntwcoxOtedn;ieobisapoiunsfnrreem,eirrnglvepognantn.aitcogineon-csntyeosrnmat (corrpwE4eeoufvep6dnptiro.uhdte5ircbeentctoegnuiFoddoce2im.ynendsgpow0teaiof.nenr4tairergmebmerhmalaeegtttasaim/onktio(nnegopn/cnlpudtoou-paawnrpyetbpesrlodoerawdrtoltehyselldieeartwevntegeeefurrclfiosnoegburcnhbaepttstysmrsiovsiLawl)snsr.D,koet5hraba0e1ebsl4teloghF.erbo.v2iAsuneegNgdtrcehvo0oane.ntte4odhtr0treahmoo.t1edlingsorim)'fnLkt.foggeDpx/Cr/kusedilcgpnai7on/scy-dlei1,ocac4ogsayw.tlniacaosatMsaniinslsnldtetLveioacDdntnsaeislo4gbcltyafrnoaotrdiisnfessyiicddtgciouwcna7pcani.eiftltciiilocgyBeoanhfonfbsstdesitsgcyienontrsnwvimfawieLcetiieDagaornnh2entt1ss mUnaldeeranthdefceomnadleitipoanrsenotfstahrees0tu.1dym, gth/kegN/dOayAEanLda0n.d4 mLOg.-AkEgrLiafvo,rrbeostphecthtieveFl0y,abnadseFdI ognenreerdauticotinons ootLihnnfOefbssAnpoigudErinmyLnigfbwifecoaerarriengotthhf0etr.ie4mgFdamp2uilncgagtn/ieakotnnagnedt/sridoafiaotnnyioopsdnaiutncepodosf,gnf1srsl.poiu6twrtmiemntrphggts.i/iaokzrngee,./d0paT.u1yhp,emrveNgias/OpkbegiAlc/idEttyiaLv,yegalayrnno,ddwbLat0hsO.4eaAdnmEdogLns/kusfgriogv/rdnivtaihfayeil,c.aFrenTlsthpgreeeecndNteuiOvrca.etAtilioyoEn,nLsbaiansnedd III. Human Data slFPeuoFvmrOelmmSs..aanrTIiyzthewyedearasienrssauT,lslPatosbFrloOeefcSlte.hnhetalsmybodeseettnercemtceeednatsinuarntehadelyissneerstuhomefsboelfroutohmde osgafemnweporlareklsepraosrpeoudclceausticporanitb,ieobdnuatblelayltomewxupaconhsdelodwtoer Occupational exposures paAPneFldraOfblsSuauomrsrfeaoarccuaehmnedpmrlBeoivcteeaelcgllsstiiuohamnnavd,pearthonbeddeuepacnrtposmrc.oeecBsaessisiuonsrmigendogonfifinatthocweirlisointerygk'cedoirnamstJapianopavuaroennl.dvasvedainilitanobblpeorotfhdroutmhcetsmm, saaunncuuhffaaaccsttuufriririnenggprpoolfatencttsioinn Fluorochemical Manufacturing apTliilfnonilceqwuwrrmuo1oioeoi9rsdarods93ncs7acMubhthhfowetraatphmoachdlemstaiupcPnA0arlatFiat.nsln1onOs,t0ggwtSltsroh-peaciasrpl9naapteh.tnr9m1eyupt3d9/malme9aypim5nnaplttespmrrDvsaaalo.cennesrylcgspsoMefaeesoettdcsuhorstmrasfrb,itrtonoo.ommwAtmh1feeel9tartst0h9rebaaye.5abm1<mo0e((6p3lmnailpMcpip=apnapnlmglmoR1ldyy7p.etAe8eopteo)rnois1aotrPw2tnad,F.tdse8O1.br39p1oST99,pt.h99phB)7meS.feaeli.rgncrTauiinThlu=migehmteie1ePP,4soFsFp9efaOOr)rPnouSSudFdmsuOlildenceSulvevgereevilchlnleesseigvlgrsiwetnhbalwesiowpnretoeehrorfermfskwosaeerl-miamrogssrphkaulentirlrnecysgde TTapmtrhecahhepotreeutoneriaricpemtltifaloepyoprdratril,ienpotcia,gayninrpeigttpdaeicrstwsoiihitopwogoniarrsuektalerrumedaedrnt.sebocfefrldoIefonuenfamrrrotaiehntdhdweegdodhaitwetoiticmahtomahcanelhta,dtnhtnisahuceyageasmmesleoebpomfdeldftairohnattneaohtgaiefttwpooopeeetrnomairrlntileyepognndldpout.epirymraroieolvvblegyeiesdrdraeeamoxwnapfd,aosesbdnmsuuenatpdrpoalistotethipymioosrentopenvolsoooiftdfywteceehodlmeeer.skapsreiIelnodtrhuywtoahmmwtaeseelmmaneectvxeahewpdnlriypsecelrasaooelsnffentt.dohtethmat sIfnlaumoorprdoleecrhoetfomeaimcdapdllrsoeysinseeetshmefprvoloomlyuetnehtsearbDyloenocaadttuu(rOreplosleafnnthteewt.maAsolcn..hito1os9rei9nn9g)t.opLrmoigmeariastmuerdeajtosebthveeinn3fModrimfpfealartienontnst,, a random years pawcltorSwpw11ehasaplfi09vooeonasnlm.9cferornrd6ccl8kkkulctueo0sh,eee(lio0mwa9earrdtwi)rshtmt5n,oleopeeey%fdiracadimronkcn.hrePcraetwadCeFthislrthTlcmhoOsieilbeiptmhsesphi0uS(leeccaa1i.iwrynatlh1ltn2alhadileee1tn6oarwei.rvms4dnnneteeerp-oog.dAiarlr0rcpmsuene.tallo11mhtdoval06hs6osocipi.pooa1sat9mvplilumuee)t4oveaivlgso4naleyprfeuheornltsllypneepcrtshtud,pt,whoheafidmoairine1edtslytlosrmr.et2,eeeshc(hdbn5m)9triocp.heg9o5auopwleh%sbalTgpllrsoeoonloehpn-ergvrtysCmeckaemPeeentlre.ceeFmleooreft0sdOsiordv.Mps.omr7teetSlanoio8Telsntlaashlyat7llhdpllelnee-yimeyrvn1se6o,vtPeaAs1.udvta1ol.nFhsdiisr2lvydsOeausy6WttoseonnhrSl)elitidctauahbrmeifoneilneaueoeebmmintttrdvrtweeeesaepetcdcd,ttostlrlohioe,saaorso'ermwkmn)gynawmeduieedspaptreonehidnaslcrr1msderrdeena,.ieee4gnlecusdr7w21atossmp6rt.4rthnhb5ildatbcaoey0sfhpniniei5nelpmjdsfwrtmogitmivpleeeonbempodemarpgfemfxlndlyuooppapsoesrenlnflos(faoaawtatcrsm1entryalruhswe8eltenipr.er7prepwgoeeltsbeadsericPoakordi,ihaFaartslenis0enkstnOicr,ormn.dedsii0Spdbi9l0(caua61.iantt1n0e-ilt3os6n. Fluorochemical Processing TcBaPlSPSffeililFanFerutivseeogreoOHoeudmalrpSShmdmorawoircogb(lainwhaehtphowiesveaetveacomnerrsasetlfartip.liifoducniprpPnnroaogrlaFlaomr3wpsOdonx2rnhataSiommtpneidafnaxrdluareodnawotcvmdeianmtceelsugeayarlcesebntaiutme0nnoaisio.gdtflue0ehonoenb4iswnmttmpuehaperemreetiopfrmetnraptdm)ltecpoleudo.eewlvfcoymettopeTyiehlronrpseeheeonlesewoodmsmewyfuroma(eecePrannsetakFspsusase=Ollug0(rot(BsrserS3.y.eSm0ueoid2=nt)reSefhrsia3nJaitnsphta2nt(eppne)teghammatwrb=et.no.ipehAouH3plwiopmo2tlre.hsio)y.aatoecherdww1rneee9iaaohsOstn9ns'sooffo9irsnft0a)tirhie.gnr.ecrr0eiggeeut9pIhugmmn6ipemlunar7ael1iearrnaTl9lfptturuyioo9lpctofyrk9hamhrm,yemicaen.otePnxSeua.wddFpaatrlenoOihgTaendsitaSnoglemetc,edfhhf.itP0eahhhe.cFimea1SgiOrl3ehaiia5crtAeviuapseepmltlsarsapannmgiwdtne..atos sotAPtnshheaofFleormnt3OussheeMpmeoSlouw.ereelfgdeopmThwvriohknephtreelhltoso1reemmsyd9ien9eewxihe8ancpeas.nor,odterhAPsapewugpFolrlercoOreoaoorswSvktrfepiewadtldoshseeortevdsauiaeni.ftlpgledfafinwmlrmniutfaioaoiacsctnrniaopan0ancgae.g0thteceli4yerenrs7mssgasaipisaentcsprmaioamJllcyap3,piplMaobrwatoeyenidedptchu(elo3awcsnaMntihisttroiahaidnRdnneiegnormSpeerctode.rroreaePt"fas,soasue0uec1ra.lda0c9r,buc29sMhl8p9ee)aria.ttunloniemonTdv0nehe.dsaP0lioselr9F"ttvy6oOaef-fSlowopoPr.pnepFmeermNOei.teeohSmsneiIomntpri,ntlhgitowlhtreayhoierrseeurdeetipgorsa,r,toauopn Non-occupational exposures numberPsFoOfShihstaosribceaelnsammepasleusre(ddaitnintgheassefraurmbaocfkthaes g1e9n5e7r)alfrUom.S.sopuorpcuelsattihornouagnhdoiuntstmhealwl orld. sasIpthnaanpemmdb1dpp9aaolln9neen8dsseo,sr2yfPtsr6ii,oFemmlO-wda4SeetU5erdedl.epSapv2pn.re0bcoal0shvv(3eideidmMnroeanipdgcoR.oearoelso3lpoeMifonrd3rtb5tsa,hieloeps1rolup9osmb9ega9cniPco)fa.FarnlolyOdTmz.sSheu,ed2Nprrpoectalhonywoimgrtcetihymnoree-gmrefiardpfvcpraaeiopatnmarllio,oestxss5osuiumitocnorhfac81teiaen59ssld9yip9ginvpe5i(bto0d3h.g0uMeraadUlpoL.ohnSerio.tctprersolaro,onicnlg1eae9tdtdhi9oe9hnf)urf.omiormrsTatanh4sgeo3sesue-eorr4acf5e adpSvlenpoaevrabnreial.oelysrdpzsoae.qcodurTlioefthodseesrafPogrobFvemioeOtrgSdar1lea8lippnmerheni1egcd9aii9norne8ngPga(Filo3oOnMbnlSstohRwosedeeagrpsubeoma9orntgt,korlesa1v5p9ie6hn9li9pcva)p.aclbrroiTo,coshawustesihrtoiehgnleeewoopteghforretoeahlpre6sah8nbwigclpaoeosroeood2glfs9ibot.haa7nennspkdaop.vabfenT.trhhaeTegeshteUiresma.nSwPag.FtaeewOsdoeS13rf4e4tlhet0ove-e65l82s0 ahtapo(VPhlnniifFieeglmaaocOrhllyshtyiyeSmtiszzrllotidieaiumtnndflrhdlgedaiytnutnhneoesuetmd6vietmsnh-eceed1gortbaa2issen6ohteaar0tnyimg0reothehoipasfapp-rlvvspesoe3aeesrdromeprtirweilsapefdpdstybacrulw)seeiirt.cnnshee5,tesrpP4lleefyioFaerqpoanuwObupnlameiebSaldcid,ynlosywtwcfmsaiezhcaamireertsmedhtopnedapmlccafveeloheeastarresnstaiociliPncsaqitgngaeFbuorndelOaenaepdgboSiunhouoefsynl(iea3tmn3/sdl1ePgMlal-iF.oeo1dnOnc1fRett5Sthresahomepbpelsooepgapsrvulbertaleat,n.mlvvets1hTopr9taeillhan9eulner9smpeUsd.)eos.ee.upSTmsiTlu.nhtoseldcemafnihotvaasiifsoeilsvddasrtnehumur;resemaappnhslg,ele.oeelcwbesdtIvllrnaeeoowetvvoalmaeeesd.rlre1ea,sotA9rrage9fymi9svtpeulndeys qasbTtrihneeeunsexpcimecytl,ruesoeaoemssnalrielsodunobinnasdttittuahteaitmebrndiearveebdtrepdheeineeerrouenmtfeospsdtreotfruiphfengsduresgraeyleamUtnpoeidnt.phndSealipcte.ccgilrsvaepiovnreoohveaegpaifroddruuvifaaileltnplbatoyhhgtali.eepcioscptanU,uIrrt.leata.oicSllrccilMea.myianppataniaibvonnotoeapeayntei,runlybooaltaehbffaltunlettiaehhosvaseenelsoiyulnnbbsazmtlslertoooohdeaoofdedddPfwuodtFchbbhroiOaaaonnPnntlgSoeFkktr.hO.spsien.oSo.sArt.rBsheilaigpeslbnooiolngd,oeraetdneslnnoloddeyomroonPacnt-elFhoroeeOnoUrsrstfS.paSdtacoh.alstneetepasvado,eleegplsfvbsruoueoirlcaaluahsxsptp.eiovaocssaOnsar,aininbegblnldyeueo,tt TAasbulemm1. ary of the occupational and general population exposure data are presented below in 4^ A lb TABLE 1 MEAN PFOS SERUM LEVELS IN HUMAN POPULATIONS Occupational Exposures Plant Location Dec11a99t99u57r, Alabama (n = 84) _ Mean (ppm) 21..4946 Range (ppm) 00.2.150--192.9.833 Ant11w99e99r57p,(nB=elg6i5u)m (Spargoacmesishianrga,PJFaOpaSn) (n19=9392) 11..9438 00.1.10--94..983 0.135 0.0475 - 0.628 General Population Exposures Source Mean (ppb) N(Scto.onrPp-aooucrlac,tueMpsaitntainofefnsaoolrta(mn(a1=n9a39g18e))rs) 47 Range (ppb) 28-96 N(Spaolganan-mot cmichauanpraaagtieonmn=aeln3t(2,1J9a9p9a)n) 40.3 31.9-56.6 Tokyo n=30 52.3 33 - 96.7 CommerIncni=taelr-g5e0n0 donors 44 43 - 44 nSi=gm-a200 donors 26 - 45 On t=he3r5Clootms mercial Sources 35 5 - 85 Bnl=oo-3d4B0a-n6k8s0 donors 29.7 9 - 56 Sna=m1p0les iii children 54 31-115 Human Hazard Data TEhpeidreemarieoltowgoicsdtuadtaieosnthtahteshpeeaclitfhiceaflfleyctasnaalsyszoecdiapteodsswibitlhe eflfufeocrtoschoefmPFicOaiSeoxnpowsuorrkeearrse. limited. Tpovappacal1esnhdlnaar9hvasolddor9euneotalil5hiletttemcsfsshiessieaoaae.etimrwnynetntaihede,rIeeotoatrweortnsrlh1emgsro;s9her(lricaoehOr9onbkotevu7ouoeelmrepwsltwrlaaldwoesbstteo.engseibvtrrfnyeheaeeeeeenentmrad.mnn,dnD,PooaAtpdhitFttellanheho.oOcosd,eaesyastdtSreh1toeteuihe9ecctelrwar9sie"om,atr8vnceeA(t,paelisrmdiogleltln1usoaaneaci9nbnylscae9ewoeatans9sbemlodac)ecsosr.coathhnwhwinsoe.pnleiAsyeilmglcmtieea)nhsnrsannetiiitwmestttafeohtncishrrawcleltoeyooliadnleaghnsprhisityitecwnuasagl,ayorddhislractcitehhamelbuihsieassednetiesstenipiiuohtPeconceasacdaFnrrtdilmiesOmsactaoctrofSboseeheonidednpnenrlitekomzetgwwetoevryeiitryeiPtemsreetheslmtFhddser.neOirihethnftPhWSietosaegiaF,srdmhthtsOiasPeefeelPnSorFrnatdFupwhOnPOmtleehdheeSFrrSvoreieOsolerseHedmdiwlSevsrsa.DrueoetualimalrLnenMmsepvaftedemlPraehlorlenaFeesoempynv.OaxewenisSnIblsoesndoorrimutiknhnmegers hdPhRE1iiiF9leggfe9Omfhhve5eSeor.PernvFnaTaWhnOtlhodfBSeorromtCfehmmtm)eoh.eniphatsehAlsooeeurvfymmrtaneeelpooremulnsnaeoe-edsywnpsjewtauhsaersoentt(irfia1cpernloi2agypcm.rz8aotfei3nloctldthreisp,peccpeaatoemaxttnendcb)dfaeooflaprtiyunnhtosndmeedtlshsoaete8crrrla8saeah,dtsroiouigtorohflenmtlete;srhBodehe(nMyoiweenowImeupnemrnopeovgraletonesyiriyroo,g,heninsaehtiiovsigsfgeifenwchetiaiehfmhnnireocfstlPasupatnFtehsuatOnsardaotctSyiseccosdiiwnloapeetcetavihirtoeeaeeenlmtdssisse,opiigwnsnlromnesitysithofbhueiekelceteteasswsrw.nttsuerti,aldetyhadynniodinl. spATbwittPrinhhneiriFhtledeefdooesOelriemvoseefcr1xSci,iea9uodn,t1nt9snedwela.bie5ed5iinleotdnvtc7oehradigeo,entrPanpylshyistdpFnsot-wbhmtefgOllhi1euevev)ecAs9wrer.easod9erranane7aetTpsnalhnsssehlocuauvdyrabeotnmlecistefhrsceesnf6pycuoonseuatorr,tnrpimluftefoosaopasndnitwlbcmefshtcu,tehttiae.eePharasonsntneFoutTsttodtbOgtfehh(uoehmamyeSaedtvgewryhtpeeDeapehiraelr.rgesoeneisithshcymhnyIoatPeeanhoratutelFauhaurs2alstOitoredndeltayegpAdietbocamehlimcertacfsesiooenhtopteisnuctnnplresgcoorut(m,eneren3ybmrotronp5iceohpuovteel-terrlpodh4erseearnys0revttwpa.eee%eattwldseholtaTs)tsraenhb.cihknrtitehaoneseeIsrattdtnehehadopw1frennaa9auupotdtlr9dhlmrlytlaa5tdepiybhctni6l.oPetlwiat1loipstinFoh2vewateOnfretsrtmepei,r,iSoos.lmtsmpatn1humnle.Tel4ocrte1haas6yphveyt9eeemee(psa9erelnespsi6psixoonm-lpboldcto1iootofmsy9ahasdms9ceinhiuysecte7darmarus.evdmutrii)ooamanoaSsnltwtnesueo1bsrsPtnelmu9ooyrFt9maeteObh7rynooSotf.ht Awhreetthroersppelcatnitveemcophlooyrteemsohratadlistyignstiufidcyanwtlays dailfsfoerpeenrtfodrematehdeoxnpeDrieecnacteusr efrmomplothyeeegsentoerdaeltermine aspocthtnonoaeameptrliueysypltzeawaiecarteiidarsorloaelnbytnyn(tsMohpjioeogsabpniDnguiddfnelieeacicslftaaicitoacnrunaintrpnddtuptieJlsloyfoaeninhdcetni(l(tcesbAhvofeoealntarwmt,ebaeid1aicelm9aSn9claM5a1d)us9.Rest6apes1Ttaserhf,aotoemnUrfrdedeaSlne,wl1at9ometv9hrrsa1eA.ij.no1flariS9blbm5ceoaa7vtmhupeesnlajmeaotsnycbpto-olfucoeofanmyudtteeriepeegaldssoote)hyrw.aieetrhheeWsossg.)hah,wreatdenhdlreeetwrshesreoewrocdkofaaertstddahaeeawdte,lreaeansdt TetnHfhomuhoelmilspwsoelbweosewvtyeureeoddroer,ykfsfos.ewhirrnaAsomcd.mleasaeontlhn,myePioanwFdsOttdohcirSetkoiofmssoneturpracudlleeymytewewlaafearosvsslerltvoleoselwarpwy-tiruevosprevmeloiyadnfleoyltthoa(ee4umxncdageoema,hanootihinnrnsetlg)yda.fnu7iTdnl4hpardeeiscerlcaeateutftrihorotesarneiown,tfmotehtrhemeeenocrtemoropthaofoolrcirrtttaatyeul.ndisteyefIeosnderosxa1dfpt,odde9rie5btia1ieeotnhnc.,ethoef IV. References (3C8MuErHrReQnetp-0oS2rtu9sm9: -`m3T7ah3rey).SocfiHenucme aonf OSerrgaa,nHiceaFlltuho, raoncdheTmoxisitcroyl"ogayndD"atPae"r,fdluaoterodoFcetabnrueaSryulf5o,n1a9te9:9. BReiepsoermt.ePierro,jeJc.At .Naon.d41H0a2rr8i7s,1,DW.LA. R19F74In. sEtiytuetaenIdncS.kin Iriration Report on Sample T-l 117. Burris J, Olsen G.W., Mandel J.H., Schumpert, J.C. 1999. Determination of Serum FDleupoarrotcmheenmt,icEapliLdeemveilosloingyS,u2m2i0to-3mWo-30M5. eFmYpIl-o0y5e0e0s-.01F3in7a8l. Report. 3M Company, 3M Medical TOCoIhLxr,iiscJtiaitanynu,SatrMuyd.Sy1.9,o9Hf9.PobFFeOYrSmI-ai0nn5,R0A0a-.bM0b1i.3t,s7a.8n.Ad r0Yg4uo/sr2k1R,/0eRs0.eGaS.rucbh1m9L9isa9sbaio.ornaO.torarlie(sS,toInmc.acPhroTtoucboel)NDuemvebleorp:m4e1n8t-al CDR19hee9srvei9esa.lt(roi8capEhnm,HLeMQanb.-tSa0ol.2r,aa0Htn0odo-r0ibeP0ese3r,rm7iIn4naa)cn.t.,aPlA/rP.oMotos.tc,noaalntadNluYRmoebrpker,ro:Rd4u.G1ct8.i-o0n1098T9,o9Sbx.ipcoiCtnyosomSrtbuSidntuyeddoyfONPrauFlmO(bSGearinv: a6Rg2ae9t)s5.F.9Ae,rrtJgiuluintsye, 10, CF22iinf1oa8ln2eR.,eMpo.Art.. C19o9v9a.ncUenSsctuhdedyuNleod. D20N7A84S04y4n7th.eCsiosviannRceatLLaibvoerratPorriimesarIyncC..eVlliCenunltau.rVesirwgiinthiaPFOS. DFleuaonr.oWch.ePm.,icJeaslsSuupr.fDac.tCa.n,tTFhCo-m95psAoncuGte.,ORroalmTigo,xGic.i.tyan(dLDPoS0w) eSltlu, dDy. i1n9R78a.ts.FSlutuodraydNo. 137-083, I* IRnattesrnwaittihonTa-l2R29e7seCarocCh a.nPdroDjeecvteNloop.m7e8n-1t 4C3o3rApo,rBatiioosne.ar(cInhc,lIundce.)s Acute Oral Toxicity Study in GMoolndkeenythTalo,xEic.Ii.t,yJSestusudpy,. DSt.uCd.,yGNeoi.l, 1R3.7G-.09a2n,dIMnteerhnraintigo,nJa.lS.R1e9se7a8rac.hNainndetDy-edvaeyloSpumbeancut te Rhesus Corporation, Mattawan, MI. FY1-0500-1378. 05/04/00 Submission. Repeated-Dose Toxicity # 1. GMSoualbdtateacnwutthaeani,R,MaEt3.IS..,tFuJYdeysIs.-0uS5pt0,u0dD-y.1C3N.7,o8.G. 1e0i35l7,/-0R04.8/G50.,0,IJSneutfebfremnrasitosisnoi,noaNnl..DRR.eesapenaedractAehdrac-neDodo,sDRee.TJv.eol1xo9ipc7mi8tybe.n#Nt2C.inoertpyo-draatyion, MGoolndkeenythTalo,xEic.Ii.t,yJSestusudpy,. DSt.uCd.,yGNeoil., 1R3.7G-.08an7,dIMnteerhnraintigo,nJa.lS.R1e9se7a9r.cNhiannedtyD-deavyelSoupbmaecnutte Rhesus Corporation, Mattawan, MI. FYI-0500-1378. 05/04/00 Submission. Repeated-Dose Toxicity #lb. 0GR4iok/r2et1nr/eL0r0,abESo.uGrab.tmo1ri9ise8ssi0o,.nIOn. cra. lETxepraetroimloegnyt SNtuumdybeorf:F0C6-8905TRin0R00at8s,. DSaefceetmy bEevra, l1u9a8ti0o.nFLYaIb-0o5ra0t0o-r0y1a3n7d8. JS8o9inh0gn3ls1eo0nO2,0rJa0.l.DD.,oGsei.bsRonik,eSr.JL.aabnodraOtobreier,s,RI.nFc..,1S97u9bas.idAiabrsyoorpft3ioMn,oSftF. CPa-9u5l,-1M4NC. inPrRoajetsctafNteor. a JDLoaihsbntorsirobanuto,tirJoie.nDs,o.,IfnGTcio.b,tsaSolunCb,saSird.bJi.oa,nray-n1od4fOi3nbMRe,ra,StRst.a.PEftae.u,rl1,a9MS79iNnbg..leExIntetnratvaenndouRsouDtoesoefoEfxFcCre-9ti5o-n14anCd. 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