Document 932wX95EoyvreBwOg82Xk2b2R

FILE NAME: Chemical Abstracts (CHAB) DATE: 1961 DOC#: CHAB043 OCUMENT DESCRIPTION: Abstract Originally Published in 1960 by Leathart 5 $ \ ^OSo) 1901 805 11I I --Pharmacology 806 ington). Am. J. Cardiol. 5, 594-603(1900).--Infusion of Experimental gastric ulcer and effect of a new antiulcer adrenaline (I) increased heart rate (a decrease occurred drug, Chlorbenzoiamine. C. Radouco-Thomas, C. Lat- when the hypertensive effect was great). Noradrenaline aste-Dorolle, C. Rogg-Effron, G. Voluter, M. Meyer, J. infusion caused a decrease of heart rate but, after atropine M. Chaumontet, and D. Larue (Battelle Mem. Inst., was given, its effect became similar to that of I. <l Geneva, Switz.). Arzneimittel-Forsch 10, 588-601(1960) C. R. Raha (in English).--Acute and subacute ulcers were induced in Some similar effects after large doses of catechol amines rats by pylo. :e ligation, immobilization or restraint of the and myocardial infarction in dogs. H. M. Maling, D. animals, or b. .hem. cotnpds. (serotonin, reserpine, gluco Ilighinan, and E .C . Thompson (Natl.Heart Inst.,Bethesda, corticoids, adrcnocorticotropin, hypothalamic exts.). The Md.). Am. J . Cardiol. 5, 628-33(I960).--In dogs, large ~ effect of Chiorbenzoxamine (I) on these ulcers was studied. doses of catechol amines cause sustained ventricular hyper I acts as a protective agent, causing a decrease or disap sensitivity assocd. with myocardial fatty changes. Both pearance of hemorrhages and a diminution of lesion inci catachol amines and infarction elevate serum glutamic- dence; it promotes healing time and stimulates formation oxalacetic and glutamic-pyruvic transaminases, lactic de- ;, of healing epithelial and granulation tissues. K. Schoen hydrogenase, and alk. phosphatase. C. R. Raha Comparative studies on the action of 3,5-dioxo-l,2-di- The hyperuricemic effect of chlorothiazide (Diuril) in phenyl-4-butylpyrazolidine on fetal fibroblasts, blood, and pregnant women. Preliminary report. Irving Siegel and bone marrow cells in vitro. M. Albrecht, J. Eschenbach, Alvin Dubin (Chicago Med. School, Chicago). Obstet, and V. Kretschmer (Stadt. Krankenhaus Moabit, Berlin). and Gynecol. 15, 220-8(1960).--The administration of --Arzneimittel-Forsch. 10, 606-12(1960).--Addn. of title chlorothiazide resulted in a gradual rise of he uric acid compd. (I) up to 7b ing.% to cultures of fibroblasts and content of the blood in pregnant women, toxemic and non bone marrow cells results in a redn. of the mitosis index toxemic. C. R. Raha similar to that obtained by triethylenemelamine and Effect of the relaxing hormone on the laboring human (, thiotriethylenephosphoramide. In contrast to the latter, uterus. W. G. Slate and W. F. Mengert (Univ. of Illinois, " I induced marked morphological changes of cellular plasma in Chicago). Obslet. and Gynecol. 15,409-14(1900).--Relaxin concns. which did not significantly influence proliferation. did not affect human uterine labor. C. R. Raha K. Schoen Clinical, bronchographic, radiological, and physiological The pharmacodynamic, action of the new sulfonamide observations in ten cases of asbestosis. G. L. Lcathart.-- 2-(p-aminobenzenesulfonamido)-4,5-dimethyloxazoIe. R. 3rit. J . Ind. Med. 17, 213-27(1960).--Discussion with Deininger and H. Gutbrod (Nordmark Werke, Hamburg, 5S references. Andrew L. Reeves Ger.). Arzneimittel-Forsch. 10, 612-19(1960).--The action Toxicity of copper trichlorophenolate established by of the title compd. (I) was compared with that of 6-(p- chamber exposure of animals. I. A. Arnol'di, Kh. Z. , aminobenzenesulfonamido)-2,4-diraethylpyridine (II). In Lyubetskil, and A. A. Akhmerova. Gigiena, Toksikol. i 1 mice the L.D. of I is 15.2 orally, 1.285 subcutaneously, Klin. Novykh Inseklojungitsidov, Trudy l-ot (Pervot) and 1.0 g./kg. intravenously; that of II 1.7g./kg. orally. Yscsoyuz. Nauch. Konf., Kiev. 1957, 304-8(Pub. 1959).-- Feeding of I at 0.5 and 1% of the food intake for a month The air in cottonseed-treatment plants showed 1.6-112.6 showed no toxicity. I was rapidly absorbed after oral tng. Cu(CHsCljO)}/ms. Guinea pigs and rats were exposed -,,administration, 80% being excreted in the urine and 9% to air levels of 0.5-300 mg./ms. A concn. of 33 mg./m* in the feces. I and II were qual. and quant, comparable was lethal after 1 hr. At 0.5-1.0 mg./ms, none of the in their activity against various strains of bacteria. animals died after 90 days. The toxic threshold is 1.0 K. Schoen mg./in*. Herman G. Rempel Fate of sulfadimethyloxazole in the human organism. Urinary excretion of chlorpromazine in man. Emery E. ; C. G. vom Bruck, F. M. Delfs, E. Serick, and V. Wolf Haynes (Galesberg State Research Hosp., Galesburg, 111.). (Nordmark Werke, Hamburg, Ger.). Arzneimittel-Forsch. J . Lab. Clin. Med. 56, 570-5(1960).--Three major urinary 10, 621-6(1960).--The absorption and excretion of 1-4 g. components of ether-sol. chlorpromazine (I): I sulfoxide in doses of 2-(p-aminophenylsulfonamido)~4,5-dimethyloxazole the free and bound forms and bound I were eliminated in (I) has been studied. Max. serum concns. were attained 5.5-7.0% amts, when patients were receiving 200 mg. - 2 hrs. after oral administration; 65-71% were excreted I 'day. On a higher dosage of 800 mg. I/day, the urinary within 24 hrs. After normal daily dosage, equal serum levels excretion was 7.0-9.0% of the ingested I. Excretion of I were found between the 2nd and 9th day, the mean total amd I sulfoxide dropped significantly the first day after excretion was 91%. No binding of I to blood cells was cessation of medication, and decreased further on the second t observed. Paper chromatography and electrophoresis day; small amts, of elimination continued for 4 days. showed that I was degraded to various metabolites which Norman G. Roth were sol. in urine. K. Schoen Changes in bile canaliculi produced by norethandrolone: Tissue affinity of sulfadimethyloxazole. W. Hinz, electron microscopic study of human and rat liver. Fenton (Kreiskrankenhaus Pinneberg, Ger.). Arzneimittel-Forsch Schaffner, Hans Popper, and Victor Perez (Mt. Sinai Hosp., - 10, 626-8(1960).--One and one half and 12 hrs. after oral New York). J . Lab. Clin. Med. 56, 623-8(1960).--Data administration of 2 g. sulfadimethyloxazole (I) to women, *rc presented which indicate that norethandrolone (I) the concn. of I in serum and in freshly extirpated uterine exerts a specific effect on bile canaliculi and that jaundice tissue was detd. The distribution quotient for tissue;serum from administration of I is not the result of hypersensi was 0.5 in both cases. K. Schoen tivity. Norman G. Roth ^ Comparative studies on the effect of common coronary Unit discharge of brainstem reticular formation in the cat. vasodilators in anesthetized and waking dog. J. Drner H . Effects of catechol, amphetamine, nembutal and megi- and E. Wick (Univ. Giessen, Ger.). Arzneimittel-Forsch. lide. Naosaburo Yosliii, Junji Matsumoto, and Hiroto 10, 631-6(1900).--Blood pressure, coronary circulation, Ogura (Univ. Osaka). Med. J . Osaka Univ. 11, 19-33 - and cardiac frequency in the normal and anesthetized dog Cl960);cf. Ibid. 1-18.--Effects of intracarotid or intravenous were detd. alter administration of a no. of drugs. Persantin injection of catechol, amphetamine, Nembutal, or Megi- had a better effect with regard to intensity and duration of fcmle on individual neurons of the pontine reticular forma increase of circulation than papaverine (I) and nitroglycertion of the cat were studied. All of these drugs exhibited ine(H). Administration of I and II was often followed by a fxcitatory effects on some neurons and, at the same time, ' primary or secondary decrease of coronary circulation, inhibitory effects on other neurons. Norman G. Roth probably as a result'of hemodynamic changes of circulation. Action of N-( l-methyl-2-pLenylethyl)-3,3-diphenylpropylaroiine on the metabolism of serotonin and noradrenaline, ^ a n s Hermann Schne and Ernst Lindner (Farbwerke roechst Akt.-Ges., Frankfurt A.M., Hscht, Ger.). Arzne imittel-Forsch. 10, 583-5(1960).--Subcutaneous injection of *-hc title eompd. (100 mg./kg.) (I) into rats reduced the serotvMiin (II) concn. of brain and myocardium by 30%, and t he noradrenaline (III) content by 50-60%. At 20 mg./kg., 1 caused an addnl. fall in III but no change in II. In cats Wetreated with iproniazid, I caused a fall in blood pressure x ''d contraction of the nictitating membrane. K. Schoen Hydroxyethyltheophylline, aminophylline, and " 4,4'-diethylamino-ethoxyhexestrol" (Trimanyl) had only slight _ effect on coronary circulation; morphine showed an oc casional effect. Com. organ exts. Recosenin and Lacarnol as well as adenosine triphosphate had no effect. K. Schoen Action of a pyrimidopyrimidine derivative on the metabo lism and oxygen supply of the heart. V. I.ochner and M. Nasseri (Med. Akad. Dsseldorf, Ger.). Arzneimittel Forsch. 10, 636-8(1960).--The action of 2,6-bis(bis(hydroxyethanyl)amino]-4,8-dipiperidinopyrimido (5,4-d]pyrim idine (Persantin) (I) on the cardiac metabolism of the dog