Document 91vDMKDbN9QQnwee40gagZBb6

V . , ILeaid ! Itafitosstei Mmmmemtimm A N D R E W FL E T CH ER,PRESID EN T K . C . B R O W N E L L , VICE PRESIDENT O . A . M A R T I N O , VICE PRESIDENT M . M - Z O L L E R i VICE PR E SID EN T R O B E R T LINDLEY Z IE e F E L D , SECRETARY-TREASURER 60 EA S T 4 2 nd S T R E E T NEW YORK 17,N.Y. MANFRED BOWD1TCH DIRECTO R O F HEALTH AND SAFETY September 13, 1957 R obert A. Kehoe, M.D., D ire c to r K etterin g Laboratoryu niversity of C incinnati Eden Avenue C in c in n a ti 19; Ohio Dear Bob: As you may w e ll know, th e r e have been in d ic a tio n s o f l a t e t h a t th e ghost o f th e a lle g e d le a d hazard from autom otive exhaust gases had not been as d eeply and f i n a l l y l a i d as we had hoped. Nov/, as you w i l l n o te from my e n c lo s u re , comes a chem ist la d y from th e U niversity' of Chicago w ith a statem ent which, w hile le s s eertrene than some, i s c e r ta in ly d is q u ie tin g . You w i l l r e c a l l , I th in k , t h a t when t h a t c ra z y Los A ngeles crew came o u t w ith t h e i r w ild c o n te n tio n s , I s e c u re d f ig u r e s on le a d in s t r e e t a i r from o f f i c i a l agencies in a number o f our la r g e r c i t i e s and found none re motely- in d ic a tiv e o f a hazardous le v e l. B efore going a f t e r Miss T u fts w ith a h o t p o k er, I would welcome word from you as to w hether you know o f any re c e n t evidence from any so u rc es which would be a t a l l su p p o rtiv e o f h er contention MB;GF E n c lo su re c c ; Mr. C o ste llo P. S . Since d ic ta tin g th e above, I have receiv ed a n o tic e of th e Semi-Annual Technical Conference of th e A ir P o llu tio n C ontrol A ssociation to be h e ld a t San F ran c isco , November 1 8th and 1 9 th , and note t h a t Dr. H erbert C. McKee o f th e Southw est R esearch I n s t i t u t e i s to g iv e a p a p er on th e afternoon o f th e second day w ith th e t i t l e "P a rtic u la te s in Automobile E x h a u sts. tf I would th in k t h a t we sh o u ld f i n d a way to s e c u re a copy o f th is paper. \ \* f K \ NEW YORK WORLD-TELEGRAty AND SUN.WEDNESDAY, SEPTEMBER 11.1957 \-Science and M edicine2 New Chemical Agents Attack Only Cancer Cells New hope in the fight earring compounds called ri " sity of Chicago chemist to the against cancer has been of fered by two research groups midines only in the of a fluorine atom a hydrogen atom. substitu in place reporting at the American He said earlier resea n American Chemical Society if meeting here today. h With the small concentrations Chemical Society's 132nd an showed that uracil, a pyri i- of lead particJes in the atmos nual meeting. Chemists from the Univer sity of Wisconsin and from Hoffmann-La Roche, Inc., Nutley, N. J., announced that two new agents have been devel oped and used successfully against cancer in mice dine, was taken into the cleic acid of tumor tissues a higher rate than into nor: tissues. This led to a "chem hunch" that the replacing c hydrogen atom with a fluoi atom would combat the car cells, he said, and experim rats. phere, no health hazard exists t for most of the population, al a le er ts h. said Barbara J. Tufts, Depart ment of Meteorology chemical analyst, "except possibly to those whose occupations re quire a constant exposure to highway atmospheres." Miss Tufts reported she drew Dr. Charles Heidelberger the University of Wisco Gasoline Additive air samples through fine mem brane filters that captured all told the society's division biological chemistry yester Dangers Cited lead particles, then chemically analyzed the filters for lead that the agents, called a: By DAVID PUKSGLOVE, content. She found the greatest metabolites, were accepted Science Service St a ff W riter. number of particles to be of a cancer cells. They prom; Anti-knock gasoline additives size that could most easily upset the metabolic proeesi containing lead may threaten reach the lung, one to three of these cells, he said, althoi: the health of persons whose microns. A micron is about they had little.effect on norrl occupations keep them in heavy four one-hundred-thousands of cells. Laboratory tests, he s; demonstrated *`a high order t u m o r - i n h i b i t o r y activ against transplanted turn in rats and mice." F u r t h e r experiments needed to determine the age; automobile traffic, although an inch. there is no health hazard to the majority of the population. A study of tiny lead particles r n r 5 iii'Hfpnuw wan Tirt h ia t t plete PHOTOGRAPHY COVERAGE formed from the combustion of fcny daily in America! Today and I gasoline containing tetraethyl pr d ay th e re 's a special featu re fo r ; r r a fans only in the W orld-Tele- i lead was reported by a Univer-1* and Sun. effect on humans, he said, predicted, however, that c rent studies would provide val uable information on tumor metabolism and might lead to development of even more po tent anticancer compounds. Dr. Robert Duschinsky, a IIoffman-La Roche scientist, identified the two new agents as 5-iluorouracil riboside and 5-fluorouracil deoxyriboside. They differ from naturally oc- HE 0014342