Document 8Vw10VgVxeGxm555xmLeoQbNm

MTASUISMCe i 35231 Centre avenue Pittsburgh, pa. 13232 DATE: February 19. 1969 Office tf Am TO: FROM: SPONSORS OF IHF RESEARCH PROJECTS Robert T. P. deTreville. M.D. FES 2 0 B69 SUBJECT: Permiaion to use Sponsors' names in IHF's 1968 Annual Report I Attached is a copy of the summary of the IHF Research Project sponsored, in part, by your company, which will appear in the Foundation's 1968 Annual Report. If you should have any comments on the text of this summary or wish to exclude mention of your organization in the list of sponsors, please so indicate on the tear sheet. If we have not received your reply by February 28, 1969, we will assume you have no objections. The copy goes to the printer March 3, and we hope to be able to distribute the Annual Report with the March issue of the Digest. ejd R . T. P. deTreville ABBOClATl** P INOUtTMiKt P T*S AVANCIM(NT R NCALtHf Uk WVOBKINO CONDITION V REPORT OF RESEARCH PROGRAMS K?' --. IHF Research Laboratory -- On January 1, 1968, 'the IHF Research Laboratory, ..established in the 1940's through Mellon Institute, became a newly-created Industrial Hygiene Research Unit within the Department of Occupational Health, Graduate School of Public Health, University of Pittsburgh. The Foundation's experimental toxicological and epidemiological research programs continue to be directed by * Paul Gross, M. D. . Research Professor of Pathology of Industrial Diseases, under the joint administrative supervision of Robert T. P. deTreville, M.D., <c.-Dr-r-3HF President,-aad Pavid-Minard, 8M.4?r,"ft.-B;T^6sinnti> olthe Be- - "u" partment of Occupational Health and IHF Advisory Fellow. Emphysema Study. Jn continuing studies of factors that may predispose to the development of emphysema in exposed populations, the tissues of animals exposed in the 1966-67 Emphysema Research Project are being subjected to highly specialized analytical (biochemical and gravimetric) procedures, developed by Herrn Dr. med. W. J. Einbrodt at Max-Planck Gesellschaft. Gottingen, West Germany, and performed in lHF's Laboratory by Jiri Turns, Ph. D., Biochemist and Toxicologist, with special interest in pulmonary clearance and tissue reaction to industrial dusts and gases. Publications based on these studies have included: "Enzymatically Pro duced Pulmonary Emphysema. A Preliminary Report. " Gross. P., Babyak, M.A., Tolker, E. B. , apd Kaschak, M. J. Occ. Med. 6^:481-484, Dec. 1964. "Experimental Emphysema: Its Production with Papain in Normal and Silicotic Rats." Gross, P. , Pfitzer, E. A. , Tolker, E. B. , Babyak. M. A. , and Kaschak, M. Arch. Environ. Health JJk50-58, July 1965. "Experimental Emphysema: Effect of Chronic Nitrogen Dioxide Exposure and of Papain on Normal and Pneumoconiotic Lungs." Gross, P. , deTreville, R. T. P. , Babyak, M. A. , and Kaschak, M. Arch. Environ. Health 16:51-58, Jan. 1968. "Alveolar Proteinosis: Its Ex-- --perimental Production in Rodents. " `Gross, P. -and deTreviiier~R.'T.-P. ~Arch. ------Path. ^86:255-261, Sept. 1968. Dr. Gross will present a summary of his findings at an International Conference on Pneumoconiosis in Johannesburg, South Africa in April 1969. (Sponsors: American-Iron and Steel Institute and Bituminous 4th r~ Coal Research. Inc. ) Fibrous Dust Study. A study of pulmonary effects of fibrous dusts is being conducted in a concurrent four-phase program. Progress in Phase 1 deal ing with the development of ferruginous bodies has been reported in papers pre sented at the Foundation's 31st and 32nd Annual Meetings, "The Pulmonary F action to Man's Environment,* " by Dr. Paul Gross and "Asbestos Bodies and Bioeffects -- A Detective Story, " by Dr. John M. G. Davis of the University of Cambridge. England, respectively. Publications resulting from this study were "Ferruginous .12 Bodies in Human Lungs. Prevalence at Random Autopsies. " by Drs. H. M. D. Utidjian,***Pa Gross, and R. T. P. deTreville (Arch. Environ. Health 17; 327*333, SepC*l968) and "Pulmonary Ferruginous Bodies. Development in Response to Filamentous Dusts and a Method of Isolation and Concentration," by Drs. Gross, deTreville, Lewis J. Cralley, and Davis (Arch. .Path. ,85: 539-546. May 1968). Phase II involves experimental studies on rats and hamsters injected intratracheally and intrapleurally with synthetic chrysotile to which nickel, chromium, manganese and cobalt had been adsorbed. These experimental animals are uriSer observation for long-term pathogenic effects of the injected ' materials. " Phase 111 involves a study of the comparative bioeffects of chrysotile, . amoartie and crocidolite as naturally occurring and when associated trace metals and hydrocarbons have been removed and its crystalline structure has been modified by heat. At a Seminar on Fibrous Dusts held November 22, 1968 at Mellon Insti tute of Carnegie-Mellon University, Dr. Gross reported that attempts to modify pathogenicity of natural asbestos, as judged by fibrous tissue reaction, have been unsuccessful so far. Proceedings of the Seminar are now in preparation and will appear in 1969 as bulletins in the IHF Medical Series. Phase IV concerns investigation, by electron microprobe and electron microscope, of ferruginous bodies from human lungs as well as from the lungs of hamsters. Preliminary results reported at the IHF Fibrous Dust Seminar showed that, from studies of the 28 ferruginous bodies isolated from lungs of as many city dwellers (Pittsburgh), all of the central cores were shown-not to be chrysotile asbestos when subjected to electron diffraction. A manuscript and editorial based on these findings have been requested by the AMA Archives of Environmental Health, and a summary to be presented by Dr. Gross at the --'International Pneumoconiosis Symposium will appear in the"proceeffing's of the' meeting. Based on these results, sponsored by the National Institutes of Health in Mellon Institute of Carnegie-Mellon University, a more extensive follow-up study will be undertaken, provided that support how being requested from indus try becomes available. (Sponsors: National Institutes of Health. U. S'. Public Health Service Division of Occupational Health, JohnsManville Corporation, PPG Industries, ^Pittsburgh Corning Corporation, and Raybestos-Manhattan, Inc. ) * Formerly IHF Fellow in Occupational Medicine, now Assistant Professor, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh.- ** Scientist Director, Associate Chief of Occupational Health Program, Field Studies, U. S. Public Health Service National Center for Urban b Industrial Health.