Document 8Vn591EmLbeZggNoG7004kgvo

Monsanto ______ #( w . Me4ie*lf A2SC March 13, 197* MCA *Nut Vnmri Asthaa" (Polyvinyl Chloride) TO George toufti Jr., MD A2BA Minutes J. dlraerth - ldTO V. Easley - 1920 C. (by - 1920 1. Corbett - 0300 0. V. Ingle - 1920 bads*eith*S5crltr*bcscd f25ty? 'StvolaM i'**U**t ] Dr. t. Soto MorittMi Dhirerelty tl Dr* K. Moser - 0. of Calif., Su Diego e) Or* V. Doll - Jotai Inytlna 9. tod. Detoool 5) Be strongly rcco--cnrted that the settlor investigator be ptlftomry physiologist rttftir than ia tpidMioloclit. la oihtr dlseuiilMf, pftrtlelpftUft ia by rfrMfttfttlm tron RSV 00037X6 Oeorge Booth, Jr. KD March 13, 1974 Pit - 3 - MCA "Moot Vrapport Atthea" cont Coaalttee will be held March 27, 1974. A Utt of potential location* and investigator* for tho epldeelology ttudy will be rtviewed. Tbt theraal dtcoapotltlon product literature will be reviewed and future analytical and toxicological prograat outlined. 3) A ty^oela ralatlva to TCM pathology will bo hold Ibf 10, 1974 In Sew Tort under tho aueplcea or MCI aod MS. Mo lnduttry contact It Dr. Deraehl of Stolon Carbide. /bkp Paul L. Vrlght RSV 0003718 ?? poses hi: :t: Ni :c THE VIKYL :HLt*RI3E RESEARCH PRui raw e, company its pr i*i : n. funds r**iuired .r . u' ' id# Su, - '*r. *'-zp ,: * ? '- '-s-arr* programs on the **- ir.-; lists .i *.".y. * . ' : 0- *r. i .r l. **;:; teratoqer.ic pr-perzies of vinyl h.\r..-. i* arc r o ance i' the research :: pciali s^r.i*ej by The l w Chew r . Cttrc u* and distributed to reiearcr. sponsors -r. - ar. . a ry . . . t" 4 . 1 is understood that our snare will be pr r a* ed .r * he tsi.s of our production capacity of vinyl chi or ide "wrr Ter pi -s polyvinyl chloride r'.un, and that in any case our crnetitjaent will not exceed S / 2 c-i .t. Signed Raise (typed) Title Company Mailirw) Address Ct y Telephone ( )_________:__________e*t. Please return one (1) signed.copy by April 24. l74_toa Hr. A. C. Clark enufacturinq Chseusta Association 1825 Connecticut Ave., H.w. Washington, 0. C. 20009 .r / .< .. u - /h /*UTA- VC I r4 /a 'eu' tteh. D.C. H-i MCA announce- -oday preltrl-.a-y 'no // t yl / chloride exposure ha a produced an^loMrcoBa - a liv<*r cancer - In ari.cc at several exposure levels. Indus* rial aiC-^'T Laboratories mho are conducting the MCA-adalnlstrre- vinyl chlorlda animal exposure s'-uey informed MCA that their wont - although eery preliminary at this point - rends to confirm the findings of Professor Ceaara Halto.;i (an Italian scientist who found that vinyl chloride exposure In rata caused cancer). MCA lamed lately notified OSHA# *IOSH, and >kPA of the preliminary toot results. Zn the MCA-administered study, rats, hamsters, and mice are being exposed 7 hra. a day, 5 days a meek to 9500 pm* 200 ppm and 50 ppm. After 7 mntha of exposure, angloaercoam Mae been observed m alee at all leeele, but not in rata or bamatera. Professor mltoal reported at the OSm beerlnge on vinyl ehlorlde February 15 that he had obeerved the liver saoear in rate exposal A heura.a day, 5 days a meek to 950 ppm for up to IS months. Mamever, he did not find the cancer In testing at the 50 ppm level. the 1 exposure study Is conducting another MCA "administered study ea the chemical, documenting the health experience of present ami feemer employees who hove worked with the amterl^ the result of which also will be released due expected to be completed In the near future. Further vinyl chloride testing Is under considerate RSV 0003720  ViAiMUi"ACTUr ..\G CKC.. 3T^ Av ^OCiA > .v-/* '> COSiilC i.. : *V N. C ** W* S- S . - JS D C . * ,, % FOR RELEASE for I:.icui.Uc JVlca;>c CO^'ACT nu L,:irJ i'. M-witt (202) ia3-u2o, cut. 2t,2 V.KSlilXG D. C., ,'prll 10 -- The liar. .'ac ur m: Ch.mist:; A>i.ycutio.) (WTA) announced today preliminary indications tha*. vi .yl ohloiidc exposure ham p'oducod angiosarcoma -- a liver :.n:cr -- it mice ftt uuvcral exposure Levels. Industrial Uio-Tbat Labors Lories, lee., eh are conducting iik> JCA-achainistcrcd vinyl chlo. ide animal exposure study, }jcA that their work -- although vary preliminary at thl* no ini -- tends to confirm the findings of Professor Cesaie VaItoo1, an Itallfts scientist the *ousd that viayl chloride expovuro is rats caused esscer. MCA Umaodlatcly motifiod the Occupational Safety amd Health Administration, the National institute for Occupational Safety and Health and the Environmental Protection Agency of the preliminary tset results. Is the MCA'-admin is to rod study, rats, barnstorm and mice arc being exposed seven hours a day, five days a verb, to 2500 lu.rlH per million (ppm), 200 pim and 50 ppm. After seven month* oi exposure, angiosarcoma las l**ca observed ih mice at all l'.vcl.m, i*U not is rats or ham^t *r. RSV , 0003721 i* I'roiv s'-o1- li iKu. i r 5. : : * O'\ .. . u, ^ O' \ . i 1 chluriJc February 15 that he had ohs.-.vvd the liver cjh m rats exposed foe: nours a day, fi\<- cits a uvl., to 250 j 4u Xor up to 12 aonllis. However, he did not find the cancer in testing at tne 50 ppm level. Too animal exposure study is continuing. Another UCA- adianlstorod study on the chemical, doc twaen ting the health experience of prosent and former employees who have worked with the material, the results of which also will be released, is expected to be completed in tho user future, further vinyl chloride testing Is unitor consideration. #r UCA-3C39 Rsv 0003722