Document 8VkdD5y6Qxd9ny4ekyzweea6m

FILE NAME: Oil Industry and American Petroleum Institute (API) DATE: 1949 A p ri DOC#: API097 DOCUMENT DESCRIPTION: Minutes of API Subcommittee on Carcinogenicity ;V ,** * r* i n y 1y ,'S ( AMERICAN PETROLEUM INSTITUTE SUBCOMMITTEE ON CARCINOGENICITY SPRING MEETING Minutes of Meeting April 1, 19^9 Book-Cadillac Hotel Detroit, Michigan MEMBERS PRESENT -- Marshall Clinton -'l.E. Curtis *-T.M. Prank t J.P. Holt T.J. Kelly '/M.N. Newquist ^ Mclver Woody VISITORS -V.C. Baird t-P.E, Boy8 ^Kieffer Davis ^ A.E. Hoag E.K, Linder E.P. Luongo R. Clinton Page B.B. Reeve GUESTS, S.J.M. Auld R.D. Bent J.W. Hammond R.A. Kehoe W.L. Simpson J.B. Stucker H.G.S. vanRaalte H.R. Warrick ADVISOR D.V. Stroop - API MEMBERS ABSENT a W.R. Levis e* C.A. Swan ASSOCIATES PRESENT ^-L.C. Beard, Jr. R.S. Bon8ih ^A.E. Dooley ^-H.G.M. Fischer J H.P. Lanke Ima ^ K.G. Mackenzie ^ H.H. Zuidema -E.W. Adams *- R.C. Cole N.J. Gothard R.M. Landon -- -F.M. Watkins Institute of Petroleum, London , Atlantic Refining Company, Philadelphia Humhle Oil Company, Houston University of Cincinnati Detroit Institute of Cancer Research Pure Oil Company, Chicago Shell Oil Company, Curacao, Neth. Antill. The Texas Company, New York TOTAL IN ATTENDANCE - 36 911230 BinEulM 0 1 5 8 4 i- Hew embers of the Subcommittee and guests were introduced. Minutes of the three previous meetings, November 11th, 1948, February 1st, 1949 and March 11th, 1949 were approved after a change was made on Page 3 . Line 9 of the March 11th, 1949 minutes by substituting the word "suggested" for "approved". Dr., Kehoe stated that of the $40,000. capital funds provided by the API, $304?8. had been applied to building costs and $8,264. had been put into special equipment, leaving a balance of $1 ,258. to provide additional equipment as needed. Of the API grant for current expenditure, there remained a balance of $22,598. as of December 31st. 1948, of which about $14,660. would be used during the first six months of this year, giving a balance of some $7,000. as of July 1st, 1949. Current expenses from July 1st, I949 to June 30th, 195 were estimated at $12 2 ,600., of which about 25$ would be covered by from payments from individual companies for testing their samples, leaving some $90,000. to $100,000. to be provided by the API. Thanks to the API grant for capital expenditures, which came in the nick of time, facilities would be available by July 1st for a colony of 10,000 mice which would permit simultaneous studies on 175 to 200 samples. The API would have first claim on these facilities; but after that, samples submitted by any individual company would be accepted for testing provided that they would not interfere with the API schedule. In addition to Dr. Kehoe, Dr. Heyroth and Dr. Dutra, 11 other persons would be required. Of these, Dr. A. Wesley Horton was already engaged in securing the necessary refinery and chemical data. Dr. J.J. Phair would start work on the . enidemiological phases of the problem after July 1st. Other personnel would in clude: a chemist to assist Dr. Horton; a record clerk to maintain complete records on all the mice; three technicians to do the actual application of samples to the mice; one technician to prepare tissue sections for the pathologist; and two animal caretakers. A principal investigator was yet to be selected. This investigator would have to be an excellent pathologist, as well as a good administrator because he would be responsible for: a. Supervising application of the samples to the mice. b. Establishing standard criteria for: 1. Determining existence of tumors. 2. Differentiating between tumors and dermatitis. 3 . Establishing whether tumors are benign or malignant. Dr. Newauist asked about the method of selecting samples for testing. Dr. Kehoe replied that this would be the duty of Dr. Horton, working with the Subcommittee and its technical advisors. Mr. Beard asked whether results of tests of samples submitted by indi vidual companies would be available to the API. Dr. Kehoe said they would be available only with the consent of the particular .company and then only on a confidential basis. Mr. Fischer thought the proposed program was well organized but wondered whether the personnel proposed by Dr. Kehoe would be sufficient to carry on all the necessary work. 911230 BinEulM 0 15 85 fractions on plants some index of carcinogenicity might he developed. Dr. Woodv read a letter from the American Cancer Society requesting the API to report the amount of money it was spending on cancer research, so the Society could include ft in their report of grants-in-aid for cancer research. Mr. Stroop was asked to obtain information on how this data would he used by the American Cancer Society. Action by the Subcommittee -- It was voted to recommend to the Medical Adivsory Committee thatt 1 - Information on carcinogenicity be exchanged with the Institute of Petroleum. 2 -- The budget for the year beginning July 1st, 19^9 for the program at Kettering Laboratory be in creased to ?100,000.00 ` A.E. Dooley Secretary Mclver Woody Chairman 911230 BinEulM 0 15 87 -4-