Document 8VJOrObq3b4jnvDRXyZ9Vpk2d

FILE NAME Quebec Asbestos Mining Association QAMA DATE 0000 DOC QAMA024 DOCUMENT DESCRIPTION QAMA Research Abstract Cards 1970s tune] : i DOT EMPEL DATE 1 Oe ' 6 Ww 1 " id emer OO WE on [op ... on See Os a, Dd EMPEL we Sts NUMBER sede .. ees ej Sag aetna --0- ree uw ... ... ... ...w...e who ... ... ... ... * Becklake 8 M. Sr eer =. ene eects VE me KLY CODE KEY WORD OH .. PAG or 2832 . AOCATION AOCATION Fournier McDonald J.C. " TETHISTLE CHAHRI TETHISTLE TETHISTLE TETHISTFLoEurnier GU GU itteinescaieny Solsenienars Rossiter Rossiter NOTE j S C. Esper NOTES eo7 : 10 "| of 72 graphic in -13-- -13-- Ralationfusnchtiionp al to radio- changes Quebec Asbestos 60 60 workers._ - 43 | Dept. Epidemiology & McGiMl cGilll 70 Univ Paper to be presented before sn. 30 |} Dresden Conf April 247680- . eee 81 _ Proceedings published 1973 pp 207-214 _.. 1. 842 son from an stratified random sample of current employees in the Quebec asbestos -- 2 _ mining industry wore studied radiologically and by lung function lesta - Wen Wen with definite but early radiological evidence of asbestosis showed reduction in lung __ volume and expiratory air flow and of gas diffusisa 3. There was a close correlation between profusion of small irregular radiological opa- _ cities and degree of functional impairment ~ The group with minimal radiological chan- . ges showed highly significant differences from the normal group 7 4. Diffuse pleural thickening alone or with accompanying parenchymal changes was associated with definite loss of function specially of expiratory flow rates T y eee[ilt DATE DOCUMENT TITLE > = a DOCUMENT T ets a ,e hte $3 wl, adn NUMBER > a2e il, ate 4 wa IMOLKED MY EDITED IT DOCUMENT NO PAGE OF 3154 LOCATION * Becklake M.R Fournier G.G McDonald J.C KEY CODE KEY WORD OR Siemiatycki .; & Rossiterges Rossite 12 Lung Function in relation to radiographic C.E. 13 changes in Quebec Asbestos Workers 43 Lecture at International Conference _60 70 on Pneumoconiosis Johannesburg April May 1969. Proceedings S.A. ,, pp 233-239,1970 233-239,1970 path INo Bulll etin o de pg athi oloe gie respiratoire 6 3 637-659 Septembre 1 | ent a} ns | - meee The relationship between chest ray changes and pulmonary funcfuntctioin on was was examined in an age stratified random sample of 1.069 m^n currently employed trays in the asbestos industry of Lastern Quebec In workers whose trays showed as yet na evidence whatever of parenchymal diseas~ vital capacity VC and forced vital capacity 1VC may have been slightly reduced while in of the presence definite minimal defdienfiitneite though minimal ray in changes changes in thethe pulmonary pulmonary pulmonary parenchyma parenchyma these ad ition were VC significant parenchymal radiological the only though function ni^ astfigments to shar significant reduction In addition VC and exercise minute ventikrien appeared to be the most sensitive indicators of the of radiological radiological disease disease For any given pradeprade of parenchymal didisseensnoso progicas calsifi function was somewhat more impaired impaired when pleural pleural thickening thickening / and calcsiafilsifi . - . incle incle 7 incle - incle incle at Iczy 315 | tation was present This study suggests that the simple measurement of VC we or PVC should therefore be of value in the periodic health examination of the bertus worker eee oe ee. toe se = . pi - wae eee es coe . Oss se we vee epmecem ww JHN JHN zs aaahnae Sines qo8 pte St $4 i, ad? LUITIU at il, #304 y DOCUMENT DOCUMENT degradable degradable ate |, ee) DOCUMCA 1000 1000 Becklake Margaret R. Fournier PAGE OF LOCATION Gis^le Rossiter E. KEY CODE 0 2 KEY WORD OR CHARACTERISTIC Lung function in chrysotile and mill of Quebec McDonald asbestos mine J.Corb^'ttNOTES . 8 Archiv Environ Health 24 6 401-409 June 1972 13 very similar to A IOEH 3154 Ref Book III 60 70 81 WIL Lung function tests were carried out on en stratified random sample of 1,015 Quebec asbestos workers whose dust exposure had been estimated from their work history and available dust levels in the industry In nonsmokers sev eral function tests distinguished the lower two dusi exposure groups These were inspiratory capacity forced vital capacity and forced expira- tory volume in 0.75 second and in 1.0 second In smokers the same tests were somewhat less sensitive Any of the tests mentioned sppear to be suitable for health surveillance of asbestos- exposed workers whatever their smoking habits x ZIXTH BETOLA 19 MEBLE MEBLE FORM 113 . TRACING CARD IHM 00740 Becklake Margaret .: Assessment of methods used in the studies of the biological effects of asbestos - C. Lung function . Paper No. 6 Conference on Biological Effects of Asbestos Lyon October 2-5 1972 SUMMARY = eeee The biological effects of asbestos exposure on lung function for may be measured by a variety of techniques depending on the purpose which the measurements are to be made If the purpose is to study an asbestos population exists health with a view to defining whether or not a hazard measu- rements of VC or IC alone or together with RV and of Dco SB Transfer Factor are appropriate If the purpose is surveillance VC IC or FVC appear to be the most satisfactory measurements though it is likely and remains to be tested that measurements reflecting the state of the __ small airways will be most sensitive to the earliest effects of | asbestos dust exposure If the purpose is descriptive i.e. to document the patho- physiological changes which characterize asbestosis in its various stages any or all of the many available tests for the study of overall or regional lung function may be used If the purpose is to evaluate the effect of pulmonary malfunction due to asbestos exposure on the overall function of the individual a detailed study of adaptation to progressively increasing exercise loads is called for : JHM 00741 KEY COOL 90 Ae tds ld, oir 1 12; fe oda ig a PAGE Biological effects of asbestos Lyon DOCUMENl or 174 LOCATION KEY WORD OR CHARACTERISTIC Report of the Advisory Committee on Asbestos SCOPE HO125 cancers to the Director of the International Agency for Research on Cancer Lyon Conference Oct. 5 & 6 1972 Ann Also Occup Hyg 16 1 9-17 1973 published in Brit J. Industr circulated Med 30 180-185 1973 IAC booklet &1973 M - Environmental Asbestos 7 pp 1973 ~ om. cexey MITA Gv: . LL FOR REHM ' oat TRACING CARD JHM 00742 " e, | | it, ze af | nme. on G > a8e - . er ay Ae ode te way 7 --... ly aT t ban INDEALD w 00CUMIA 00CUMIA NQ by } DOCUMINE Perce Duci~ hee - -+ PAGE OF 3622 LOCATION Duci~ .: KEY CODE KEY WORD ON CHARACTERISTIC | SCOPE NOTES 36 Accuracy of causes of death - A comparison with autopsy diagnoses serii n se eris es of mesotheliomas and other malignant tumours of the lung 38 L'exactitude des causes de d^'c^s- Une comparaison avec les dia- 73 70 gnostics ^ l'autopsie dans une s^'rie de m^'soth^'liomeset autres tumeurs malignes du poumon COMPLETE TEXTS IN FRENCH & ENGLISH 395-402 81 Can J. of Public Health 62 39 Sept 1971 Summary and conclusions In a series of 67 autopsy and pathological dia- {ITH gnoses of malignant mesotheliomas of the pleura and peritoneum we were able to demonstrate agreement with the certified cause of death in 10 cases 14.72 In 26 mesothelioma was reported as benign or even if stated correctly coded as another tumour In 31 the real disagreement diagnosis and the official cause of death were in ; El 2106 w' o: - BLE FORM KL.1336 ' INDEX / TRACING CARD w< ited OVER SVP e S e SCSC:SCa CC JHM 00743 r batc " wie ee [rede | J batc 14 H " ry FREE 40 ? : , PAGE DOCUMENE TI~ E : ee ~ JUHILD OT 1 ~ 2 : |: PAGE : OF . ~ MKUMENT AJ 163 Fournier ae KEY COUL Gis^leGis^le KET WORD OR CHARACTERISTIC CHARACTERISTIC LOCATION SCOPE NOTES Pulmonary function in Qu^'bec asbestos_workersasbestos_workers 32 McGill Univ 168 pp 1973 81 CIRCULATED pp 105-106 E PP II 4, Genel tl DATE : ity INDEXED BY " he aS: il, e > s |, eda 3 eae afr ade afeia COITED ST at DOCUMENT DOCUMEKUNMBT EA SCRA DOCUMENT NO DOCUMENT TITLE PAGE KEY CODE 13 12 70 Fournier Gis^le Becklake Margaret KEY WORD OR CHARACTERISTIC II - Epreuves de fonction respiratoire Bulletin de pathologie respiratoire respiratoire 6 661-667 1970 OF 3362 LOCATION R. al SCOPE NOTES 60 LIL - Appendix Tests of respiratory function 76 Seealso 81 3154 \ CTO Gor Sat one TRACING CARD GIBBS G.W Comments on standard international methods evaluation of asbestos dust exposure for Pernis B. and Pelnar .: Transcript of the Meeting of the Committee and International Colloquium on Asbestosis * Sardinia September 24-26 1970 Montreal 1972 pp 18 19 20 Gibbs G.W. & Du Toit R.S.J Environmental data in mining Paper No 21 Conference on Biological Effects of Lyon October 2-5 1972 Asbestos SUMMARY not provided by authors The mining and milling environments are probably the only ones where the effects of the various asbestos fibre types may be studied separately although exposure is often to other well materials as Comparisons are made between the mining and milling environments of asbestos producers throughout the world and the current states of dust measurements and dust control are described JHM 00746 . - _ ry) bs BOLUMEN "8 teill KLY CODE . .f. Peworenwae M_ eae SetHTON re Te ae we Tn oe SetHTON HY Rn rio han ot , Gibbs Graham W. Maurice & Lachance Maurice = KET WORD OR CHARACTERISTIC exposure chrysotile asbestos asbestos mineos f Quebec 4 |. Archiv Environ Health 24 189-197 59 March 1972 60 --- mew --- cnryso Past and present features or ^fineQuebec tile mining and milling environment and methods .-- 81 81 t 43 43 ee 53 - u~ sed to establish Indices of exposure for epidemio- logical studies are described Environmental dust ssuem= concentrations used for calcuation of dust exposure Indices were derived mainly from systematic midgel impinger samples laken since 1948 and from field surveys made in 1966 using impinger and a vari- ety of other techniques Though dust levels within the Industry fluctuated widely there was a steady fall from an average of approximately 75 million particles per cubic foot MPCF in 1948 to less than 10 MPCF in 1988. Considerable variation in the fiber content of airborne dust in this industry suggests that any safety standard should probably take account of fibrous and nonlibrous componenit VA 7 4 va VA wietces + Weg Hoe hee ed 45 K. o 3507 | incation incation SCOPE NOTES . ; ceality " MH f I DATE D 1 INDEXED BY 11 Af, 2188 1 A A t ' 33 I, DOCUMEST DOCUMEST NUMBER 21 ete 1 COITED OF aa DOCUMENT NO DOCUMENTTITLE DOCUMENT DOCUMENTDOCUMENT Gibbs William Graham William & Lachance PAGE Maurice: OF 3918 LOCATION KEY CODE 0 KEY WORD OR CHARACTERISTIC fiber relationships in the Quebec SCOPE NOTES 2 chrysotile industry : = 3 Arch Environ Health 28 69-71 Feb. 1974 69 76 81 Epidemiological studies of Quebec chrysotile miners and millers have related various indices of health to dust expo sure as measured with the midget im pinger The interpretation of these rela Honships in terms of liber necessitates the conversion of midgel impinger par- ticle + fiber counts to membrane filter . eee liber equivalents An Investigation In which 87 side midget impinger- membrane filter samples were taken at five mines and mills showed that the cor relation was poor and no single canver sion factor was justified Until more de- / a ee pe oe os tailed information on the relationships belween midget impinger and membrane et filter counts can be obtained obtained it is recom- ew ee et 1 mewn ened ew ee ere mended that safely sl^/ndardsat least in this industry should continue to be based seem on dust counts for which there is consid erable epidemiological support rather than on fiber counts for which there is no direct evidence som | Kt tne mee Lee coun d+ 6 SL Cer te tee a ke tout ee oe Lee bbe eee ee a a a _- 00747 ee 00J7 HM 4 00747 7 yy a ry  UATI DOCUMENT __. pit 1971 InterhnateCelassification Ttlyf ILO C e eeT ee, wae ee. Clas ification Clas ification = Sesse QoS See PAGE Clasifcation etc ee a Sow oT DOCUMENT NO 01 181 LOLOCCATIAONTIOLOCATIONN KEY COOP KEY WORD OR CHARACTERISTIC CHARACTERISTIC scort NOTES JLO_U InternationalClassification of 76 Radiographs Pneumoconioses Medical Radiography and Photography 48 3 67-112 English - French - German English version DD 67-76 ~- Will WillWill Wil Will DATE DOCUMENT TILL bie: KEY CODE 13 71 76 81 pelos s]r oe oa ay > INDERED BY Jodoin Gilles 45 2 aE : EDITED BY mk raat DOCUMENT KUMBER ~~ PAGE Gibbs G.W. Macklem P.T. ae eta eo OSCUMENT 40 OF 3570 LOCATION McDonald , J.C. & KEY WORD OR CHARACTERISTIC Early effects of asbestos exposure Becklake M . | lung function Amer Review of Respiratory 104 4 525-535 Oct. 1971 Disease the } In an attempt to define early effects of asbestos exposure on lung function detailed studies in- cluding tests of pulmonary mechanics were made on 24 workers who had normal chest radiographs but whose exposure to asbestos ranged from 6 months to 24 years The 13 men with greater ex- _ . posure showed on~the average a significant 30 per cent increase in the static recoil of the lung when compared with the 11 men with the lesser exposure In addition they had smaller vital ca- pacities evidence of greater regional inhomogeneities of venulation and larger maximal mid- Te ~_ expiratory flows changes in keeping with the presence of a restrictive type of lung disease By wo contrast at any given transpulmonary pressure peak flow was less in most of the men in the more exposed group indicating an increased upstream resistance This suggests that the changes respon sible for the increased elastic recoil had a peribronchiolar rather than an alveolar location in keeping with what what has been shown in laboratory animals The changes in pulmonary mechanica were considered to be early because they occurred in men who had no radiographic evidence of ~~ disease or defnitive changes in aller measurements of lung function The findings suggest that exposure to asbestos dust is another cause of obstructive disease of small airways . aa wee ee. od - --x + i co eee ee + wees con Oe ee ee we se To JHM0743 JHM00743 JHM00743 - . : WATL DOCUMENT DOCUMENT FEEL ; KIY COOL -~ we ls" oa were e McDonald * oT J.C KEY WORD OF ar ao eersy oo lore we \ CHARACTERISTIC CHARCTERISTC CHARACTERISTIC - 70 Research on Asbestos and ".. = ~ me Health 10 A progress Report to Employers and | 36 |Employeesthe 38 | Mining Industry . 43 McGill Reporter QuebecAsbestos 2 24 p 18 10 _ .60 _ - - ee ee IPAGE April 1970 81 . ~~ it dough we == or _ 1139 LOCATION SCOPE NOTES DATE / DOCUMENT ieae rhe son > ade if, INDEXIU OT EDITED BY DOCUMENT KUMBLR |, Sd pe DOCUMENT NO PAGE OF 3497 Bara KEY CODE LOCATION Fournier * McDonald J.C Becklake Margaret Fournier Gis^le KEY WORD OR CHARACTERISTIC Rossiter C. SOPE NOTES | 2 |Respiratory symptoms in chrysotile TI asbestos mine and mill workers in Quebec 60 PUBLISHED Arch Environ Health 70 24 5 358-36Ma3y 1972 A standard questionnaire was administered to an stratified random sample of 1015 - current male employees in the Quebec asbestos mines and mills Ine prevalence of bronchitis defined as persistent cough and phlegm was related most closely to age and smoking habits but in smokers and light sholers - also to dust exposure Breathlessness on exercise was related to age and dust exposure but not to smoking ae qr eer _ -- pee EO y Dall & a Cube atte ne nd re ce Cueoee ae DOCUMENT OL DOCUMENT DOCUMENT tit Gibbs McDonald ia J.C .; Gibbs G.W KEY Cont KEY WORD OR CHARACTERISTIC CHARACTERISTIC Storagasea factor in disease 25mineral dusts i ig EE , oan Manfreda J. due to : a epe vaiineeeunenenen 7 ee .* Cu AP A I'AGE 01 & White 3976 se UOC 3976 eee waacone 1.M. | SCOPE HOTES en ~ - 36 Multiple Factors_in_the_Causation Factors_in_the_Causation EnvironmentallyInduced Disease - 40 Chapter 12 185-201 1972. .: DHK Lee Kotin Academic Press 81 a filet ch v/s 3967299966726986989 9672996689 1 DOCUMENT 9672996689 a= 52 DAZE aa H 2 INDLRED BY 9672996689 1 9672996689 96729689 9672996689 96729689 oo COITED BY BEH DOCUMotEeNT KEY CODE 2 3 McDonald J. Corbett McDonald Alison Alison KEY WORD OR CHARACTERISTIC Siemiatycki , Mortality from lung cancer and other causes in the chrysotile PAGE DOCUMENT NO OF 3042 .; Gibbs Gibbs , LOCATION Graham .; Jack & SCOPE NOTES Rossiter Charles E. 20 asbestos mines and mills of Quebec Arch Environ Health 22 677-686 1971 37 38 43 60 70 a | Of 11,788 persons born between 1991 and 1920 employed in the Quebec asbestos mining industry 88.4 were traced Of these 2,457 23.6 had died Exposure indexes for each worker were calculated from job dust levels and duration of 81 T e employment The overall mortality was lower than meanenxepr ecetnes d for the population of Quebec but in "F ~~ eee the highest dust category comprising % of the cohort the standardized rate was 20 higher "_ than in the other groups Respiratory cardiovas- | cular and malignant disease in equal proportions _ -___. = I accounted for the excess There were 101 deaths from respiratory cancer including three from malignant mesothelioma an estimated excess of about 15 deaths The difference in rates for re- spiratory cancer between those maximally and Nene mm nrnnee minimally minimally exposed was hvefold and though per- haps exaggerated was apparently determined by . becumulated dust exposure and duration of cm- co ployment ' at | { | i 777 , -. J a TT mee vs A fee oe eee ee a rew ee cee Ue ee TTT re ee ee eee mam ome fe a cae 00750 00750 eee MOV eee - Ee wetter me - MeDonald J.C Cancer in chrysotile mines and mills Paper 29 Conference on Biological Effects of Lyon October 2-5 2-5 1972 Asbestos SUMMARY Evidence for a link between malignant disease and occupational exposure the fact in the chrysotile producing industry is not strong This despite that men dying now were exposed for many years to much higher dust concentrations than prevail today More results would of course be useful and no doubt research methods can be of chrysotile miners and millers has improved been on a nevertheless the larger scale than investigation that of workers other asbestos and generally with much more of exposure results The appear to show that there information is modest on levels increase in respiratory and probably intestinal cancer in this industry most serious in those who have been heavily exposed over long periods This hazard would probably not be detectable at exposure levels below about 200 Amppcf ie 40 years at appef The fibre equivalent for this figure has not been established but Quebec data indicate that it may be in the neighbourhood of 10 fibres per ml and The link with malignant mesothelioma is also weak there is no evidence of an association with peritoneal tumours Chrysotile tumours are too few to permit any firm conclusion on response The fact that there have been ences in Canada after occupational and domestic neighbourhood but not purely exposure suggests that low duct levels mining prevailing in communities have not been sufficient to cause the -_7 discuse JHM 00752 | | : : vere DOCUMENT GE Qatar ws KEY CODI 1 Ge " ' 1 |, te FL! if HT FANTIL $e . fas a4 bouti we .; Rossiter KEY WORD ON CHARACTERISTIC ae |. } DOG ee 41 Rese . - 7 wd) ate C.E Eyssen G. wf ats 1 ..... aa of 3510 LOCATION LOCATION & McDonald McDonald A.D SCOPE NOTES <= Mort |aMl oritt alyity the chrysotile producing 36 industry of Quebec A progress report Bucharest 38 _ Lecture_ Internat Conference on 43 _Pocumoconiosis Sept. 1971 in Bucharest Bucharest Bucharest , 60 | {| 232-237 in Proceedings ~_ From the records of all persons ever employed in the Quebec asbestos mines and mills for one month or more a cohort of 11.111 11.111 men and 468 women born 1891-1920 was defined and is being kept under close review Environmental dust counts and detailed occupational histories each employee At have been used to calculate indices of exposure for the end of 1969 3.228 28 per cent were known to have died 125 from lung cancer & from malignant mesothelioma and 32 from pneumo F 70L heavily Pul coniosis Total mortality continues to be lower than expected from the ventral population except in small proportion proportion exposed to dust fibrosis and respiratory malignancies are main cause of this m exo censs, which seems directly related to the indices of exposure The im- plications of these findings and their relation to those observed under other conditions of asbestos exposure will be discussed a ee 1787778 . ealili C DOCUMENT vr oS: a= KU edn 1787778 1787778 1787778 at, a DATE INDERED BT DOCUMENT TH Rossiter KEY CODE EDITED BY DOCUMENT no PAGE OF 3484 . Bristol Grainger Cartier P.H Gibbs KEY WORD OR CHARacteristic Grainger G.K Gilson- T.R. Siemiatyckiejts; Dust Cremer G.K. & McDonald J.C ... exposure and radiographic appeareances : = 12 in asbestos workers 30 Lecture Internat Congress Occup Health 31 Tokyo Sept. Proceedings 1971 205-206 70 81 Js ome a] ween b In the Quebec producing industry dust measurements and annual chest radiographs of employees are available for many years The estimated exposure for each of 15,000 workers has been related to changes seen in their radiographs using the Cincinnati classification There is a clear relation between exposure and the profusion of irregular small opacities The degree and distribution of pleural thickening are also associated with exposure Calcified pleural plaques are linked with employment in one particular area but are virtually absent elsewhere 00753 JHM00753 net ren. ee ee ee eee l: in ] 4 ot 1 j [23 fa ahi aSes Oe ee an ra r 2 1 - an a hea - DUCUMENT oe ON ae Ros iter [ern PAGE oF Fme TE umn ew. 3511 wee LOT & 110 RossLOBEit &ReorssiterC.F.; Bristol L.J Cartier P.J P.J .; Gilson J.C LOBE se C KEY WORLD OF CHARACTERISTIC GraingeGr rainge,r Cr amam G.K. G.K. E : 12 Radiograpchah nges ic chrychrsysootitleile 12 asbestos mine and mill workersof Quebec 30 McDonald J.C. , Environ 389-40 31 60 PUBLISHED PUBLISHED . Archiv Environ IN: Archiv 3/14 3/14 Health : June 19 70 B1 " O Radiographic changes in 13,021 employees were assessed in 6.529 men aged 35 to 65. The prevalence of rounded small opacities category 1/0 or more rose with increasing dust exposure | | : | a Wa 3 from 0.5 to 3.4 that of regular sm^ll opa- cities category 1/0 or more from 2.2 to = 17.0 and that of pleural thickening grade 1 or more from 1.4 to 12.3 Small opacities or pleural changes were seen in 17 of men but 3.2 had both At present dust exposure levels much lower rates can be expected The preva- lence of radiologic changes was higher in the Thetford Mines area than in the Asbestos area This was shown by pleural changes more than parenchymal changes and the differance was extreme was with pleural calcification which absent in Thetford Mines but virtually In Asbestos Book I GH * C142 MEGEL FORM KL 730 TRACING CARD JHM 00754 . ~ an TUQLAMEKE HILL alae CouraE KIY Cour cme'toaa so wi a we" SPAGE 3607 * ae ann Vanier oe PAS Oe TEN _ ot yt tee Rechte ee OE oom end Fe ee ee SPAGE os no Asbestosis Group 3607 Neuner Neuner on Work of 7 Ai Air rbb orno e r Nen une er <F BST Asbestosis Asbestosis Asbestosis Asbestosis Group 2 on - KFY WOND OR CHARACTERISTIC ] SCOPE NONIS mons 2 Evaluation of asbestos exposure the Working Environment 41 1 76 Industrial Medicine & Surgery 28-30 January 1972 SUMMARY A working group of Committee on Asbestosis presents its international agreement on standard methods in Enviro Enn vim ro e nm n et nt 8 71-73 1971 " 1 " J. Occup Health 14 7 560-562 July 191 Medic deliLn avoa ro 11 11 63 1-2 1-6,1972 1i1t " 1 Gigiena i Sanitaria @ 2 76-79 1973 ~ - - ils > 132 waipli sah J 4 0420 cfrOcMEAT AUV BER DATisE Sn f INDERED BY LOITED ST e2acls TPAGE ety is i DOCUMENT ND OF LOCATION DOCUMENT TITLE KEY CODE UICC Working Group KEY WORD OR CHARACTERISTIC SCOPE NOTES 12 Cincinnati classification of 69 radiographic appearances of pneumo- 76 coniosis Lecture XVI Internat Congress Occup ____| Health Tokyo Sept. 1969 pp 179-181 Proceedings 1971 re it ro _ _te 7 Bollig H. Bristol L. J. Cartier P. Clarke W. G. Felson B. Gilson J. C. Grainger T. R. Jacobson G. Kivuoloto R. McDonald J. C. Pendergrass E. P. Rossiter C. E. Selikof 1. J. & Cremer G. K. McGill University Montreal Canada Three interested international group have extended the ILO 1958 Classifie cation by differentiating between the small rounded opacities frequently seen in ro mineral pneunwconiosis and the small inegular opacities seen in asbestosis and some other pneumoconiosis The other main extension is the grading hy reference to standard films of pleural changes The practicability has been T confirmed in 42,000 readings of over 15,000 radiographs from the Qucher asbestos industry Twelve readers from six countries have also tested the classitis cation on 100 radiographs Inter- and observer variabilities are simulat a to those in trials using the ILO en Ot ry Classikuution Classikuution wom fe ee : te ee ee ee te . - _ - woe fee _HM_00755 _HM_00755 eee ee tet mw e me 8 - wm _HM_00755 mmm . ee _HM_00755 we _HM_00755 - = + JHM 00756 Project No. 2 - Epidemiological study of primary malignant tumours of the pleura and peritone^,,m in Canada All cases of primary malignant tumours of the pleura and peritoneum that occurred in Canada since 1960 to be registered and two matching patients Relative control series to be found one series comprising with secondary malignant disease of the lung importance of previous exposures to 1 asbestos at home and at work ) other environmental carcinogen 3 tobacco smoke to be investigated in the epidemiology of mesothelioma Cost 6,940 Dr. J.C. McDonald M.D. Department of Epidemiology McGill University Montreal and Health IHM 00757 a DATI A, nd UULUVIAI Jov 3824 ... ... Fit Alison McDonald Alison D. Magner Desmond & Eyssen Gail ITATION KEY CODE KEY WORD OR CHARACTERISTIC SCOPE NOTES NOTES A 38 Primary malignant mesothelial tumors in Canada 1960-1968 70 pathologic review by the mesothelioma panel of the 73 Canadian Tumor Reference Centre 81 | Cancer 31 4 869-876 April 1973 Six pathologists reviewed 119 of 105 cases reported as primary malignant meso Chelial tumors between 1960 and 1968 in a Canadian national survey Based on histologic observations only the panel was in favor of the diagnosis in 50 ' OF uncertain in 1966 and against in 36 This distribution was similar for pleural and peritoneal tintors In males the diagnosis was favored more often informattion han in females compcompared ared to 26 Clinical and additional patholgic pathologic information changed the apinion pathologists apinion little A mendier of the pathologic UK ! Mesothelioma P_ anel who reviewed 14 of the 119 cases recorded essentialls simi- lar opinions Subsequently a further 21 cases were registered between 1968 and 1970 and reviewed pathologically The 99 cases in all in which the panel fa_ vored the diagnosis of malignant mesothelioma had been exposed to 25bulbs slightly more frequently than the rest Twelve of 20 1698 tumors classified histologically as mixed were associated with asbestos exposure compared with 8 of 73 % classified as epithelial or mesenchymal Fe } . epee eee FL E rarer fn |s 0476 E INDEALD BY DOCUMENT TIZAL Pere red arrPOCUMENT POCUMENT Nuvers Faery $ ee POCUMENT Nuvers EDITED BY O PAGE OF 38793879 ~ KEY CODE 38 70 McDonald Alison D. & McDonald J. , Corbett KEY WORD OR CHARACTERISTIC | Epidemiologic surveillance of mesothelioma in Canada LOCATION SCOPE NOTES 73 Cdn Med Ass'n J. 109 5 359-362 0 1 Summary The number of tatal malignant mesotheliomas _ 60 61 1 63 was ascertained for the period 1960-70 by contacting all pathologists in Canada The annual incidence was steady between 1966 and 1970 at 1.4 per mittion population Of 71 cases registered in 1968-70 and not previously 81 . 81 reported 66 were preural 24 peritoneal and the ee] waere emainder in both sites 45 of tumours were in women The diagnosis of mesothelioma was approved ] by the Canadian Mesothelioma Panct in 597. Sixty meee 6cases were successfully investigated epidemiologically A history of definite or probable occupational asbestos amt exposure was found in 30 of male cases compared with 11 of controls but in none of the female cases or anf controls However anyong cases four women and one man had had domestic exposure to dusty clothing [~ 1 of an asbestos worker Most of the excess occupational . exposure was in the manufacture of asbestos products i _ ]~ nt em or insulation and little in mining or milling No case other than those occupationally or domestically exposed had lived within 20 miles of asbestos mines or mills - 1,1973 | oe nel Veere L 09166 Per f 104 104 TUM : There em rages . DOCUMENT 31 & McDonald Alison_D Desmond app Marner a KET CODE KEY WORD DR CHAMACTERISTIC 1 i , ety it as ae oy ee ae ree PAGE or L ee ee DOCUMENT MU 3734 LOCATION Des SCOPE NOTES 38 | mesothelial tumors_= __| histo typl e ao ndg asbi estc os exposure __New_England__J New __New_EnglJa.ndM_e_dJ_ , 570-571 73 60 Sept. 14/72 | Also published L.Annals the _61 _|_Royal College of Physicians and 63 Surgeons of Canada 6p 58 1973 70 81 eels eel! C ,DOCUMENT27 1/1 DATE : C : 1 I 2 M , 7 5,1 5,1 che INDEXED BY EDITED BY 27 1/1 ode Y DOCUMENT NO DOCUMENT livet ; McDonald A.D Harper .; El Attar KEY CODE KEY WORD OR CHARACTERISTIC 0 Epidemiology of primary malignant mesothelial tumours in Canada PAGE O.A. & or 3155 LOCATION McDonald J.C SCOPE NOTES 38 Lecture at International Conference 36 on Pneumoconiosis Johannesburg S.~ . 60 April 23 - May 2 1969 61 62 Summary of Results An association with definite occupational occupational exposure to asbestos or probable 63 63 only only 20 of male was clearly demonstrated but Almost Almost all the cases and and one female case had any such contact excess was in the manufacture manufacture and industrial 70 of asbestos rather than in mining or milling milling 1 found with lessor lessor degrees of occupational asbestos asbestos mining areas but there exposure residence domestic was a small excess excess of possible amd main exposures The smoking histories in control groups were almost identical the mesothelial ..-: and unlike those for cases of primary lung cancer -_ PUBLISHED . !! Con 26c ) e9r 14-019914-019 October 1972 PROMENET.65 PROMENET.65 PROMENET.65 Internat Conf Pneumoconiosis 197-203 published 1970 received 1971 OE . Oe a Scart pow Se beet en SP ee. ee W022 eal= ered em ~ 00759flflfl INDEX TRACING CAND JHM 00759flflfl JHM 00760 Project No. 3 - Chemical and mineralogical studies of chrysotile asbestos with particular reference to oils and waxes Samples of rock and dust to be collected in a carefully controlled manner pulverized and extracted with organic solvents The extracts to be examined for polycylic hydrocarbons and other chemical constituents The aim is to investigate their presence prior to any processing of the rock Cost $ 17,750 Dr. J.C. McDonald M.D. & Dr. G.W. Gibbs Ph.D. Department of Epidemiology McGill University Montreal and Health 4, op i? were| temae| a i teow talt a i 11 " r 8 t : seus bap ye m . ee VOLUMENT TITLE . eee . . Lia a levee bavtgae toe DO Gets treende, ~- OO dalasa. SF soe _ ee Aa-2 | nae +e i/ 2146 140 4 Caf.f or 3736 1 - ker cat | KEY WORD OR ILHISTIC SCOPF NOTES some iia Contaminating organic material in some 43 asbestos their 81 The _**__| British 358-362 6 organic organic 82 1969 products . material Cancer 358-362 material material organic material some organic made organic these polythene polythene products products weakly weakly constituents is constituents _ asbestos beenpolythene extracted are asbestos contains bags these contains polythene contains also in but of Some Some from asbestos constituents asbestos constituents asbestos asbestos discussed discus ed some discussed constituents polythene extracted products are discussed 5 constituents constituents constituents asbestos extracted extracted products shows constituents material oxidation finding that the constituents contact material material contamination known contamination contamination presented when the organic organic implications presented presented contamination only make organic the only make organic organic implications implications contamination they whether - contamination that whether Evidence however comprises the known comprises is however Evidence comprise contaminationEvidence comprises : contamination formed It know but : arises contamination identified know carcinogenic Summary contamination products identified not carcinogenic " Summary contamination identified carcinogenic The contamination oxidation identified identified carcinogenic oxidation been carcinogenic are are oxidation carcinogenic VIITSIOO have carcinogenic carcinogenic carcinogenic carcinogenic of - J. April Cortes ELT ! 1970 90uM CEL xeL .g1d 7 0415 0415 10 OF , . TRACING CARD EDITED BY tiivebstoy tite i DOCUMENT TITLE : KEY CODE _ * Gibbs Graham Some KEY WORD OR CHARACTERISTIC Problems Associated with the = PAGE ben _ so: EsDeum aaa 10 3040 3040 LOCATION SCOPE NOTFS a ; Storage of Asbestos Polyethylene : 43 Bags - Dept. & 43 _{ McGill Epidemiology HithHith Ref.Letter to Dr. G.W.W. July 1968 ne Published in Amer Ind J. _.... - 30 458-404 Sept. Oct. 1969 eee ee esas eee oy wom sane on sme . Samples of milled Canadian chrysatile asbestos collected and stored in poly ethylene bags were found on extraction with benzene to yield a^fllsin sulisantially sulisantially greater quantity and with at least one different constitucat from those collected and stared in glass jars The constituent isolated from the asbestos collerted in cert polyethylene polyethylene bazy is yellow and shows a strong absorp^>^>nuhund at 421 ma Extracts is coutin this of chylene bygs do not coutin this coupeunit but the compound is formed ou the introduction of ashesins into the lag The relevance to sample collection for subsequent organic analysianalsysis and to animal experiments for tests of earrinogenic activity - of samples of asbestus asbestus and other substances is discussest * . - e . - ay we fee wee raecle ea 11 s- ee ee ee obese ads, ole ve BO UMES12304 Tee oe oe .... oe ee. ... ... eomee DOCUMENT ; " rad Gibbs * v KEY COUE Gibbs Graham .: KEY WORD OR CHARACTERISTIC CHARACTERISTIC 8 Asbestos fibre contamination by storage storage in 81 polyethylene bags PneumCo onc f Po nen umoi coo nios sii s _s Johannesburg _Johannesburg: April 23 - May 2 1969 punonary PROCEEDINGS pp 165-169 1970 No Lj or POLUMINI POLUMINI N 3459 LOCATIO LOCATIO SCOPE NO105 - Po a a's > ' 0 F -- 4 53 if, af: \ ...ada rf, ... A0 ... ... 22, ' wef OYCee DATE INULZED 44 EDITED BY DOCUMENT DOCUMENT NO DOCUMENT TITLE PAGE OF 34.10 LOCATION KEY CODE Gibbs G.W KEY WORD OR CHARACTERISTIC SCOPE NOTES 8 Colleacndtsi too ran ge ofsamples in 56 organic geochemistry 76 Cosmo et c Coh smoi chim mii ca c Aca ta 81 34 629-630 1970 - ~ eo - ao sr ee ee ee es te cee ees ee eds em ee eee oo ewe : - s ert See INDEX TRACING CARD ee ee DOCUM 4 so fs tr 4$s t hf a # G6 ot rr a SS eA RD eee | |, 243 et OS DILLO MY DOCUM Gibbs CODE [| .: KEY WORD OR CHARACTERISTIC 1 DEAL 1 STAGENT_KUNDIE STAGENT_KUNDIE STAGENT_KUNDIE dust 0 Qualitative aspects exposure 2 in the Quebec asbestos mining and milling 5 industry to teria . SS an ~_ - - ~ DOCUMENT DOCUMENT 41 PAGE or 3402 _ LOCATION SCOP NON _ 6 ; 8 += 3rdSympoos n i Inhu alm ed Particles BaQ.H.S. London Sept. 1970 Proceedings published 1971 pp 783-799 ~ 43 60 : 81 56 - ABSTRACT - Recent epidemiological studies of workers employed in the Quebec asbestos mining and milling industry have described relationships between dust exposure and indices of health The quality as well as the quantity of dust to which workers are exposed varies within and between mining operations Toss - report describes some of these qualitative factors with particular reference to ergonic constituents trace metals dust mineralogy and radioactivity Levels of sirborne polycyclic aromatic aromatic hydrocarbons in mills , and levels of radon daughters in underground wines are both considered too low to play any significant role in the lung cancer mortality in this industry The trace metal content of ceil ceil fibre varies between mines and airborne trace metal concentrations in three mills investigated vere found to exceed levels reported for textile plants The importance of dust chemistry physics and - mineralogy in experimental and epidemiological studies of the effects of asbestos is discussed 434 RIGA RIGA RIGA CRC RM 19558 TRACING CARD JHM 00764 i ee if, hy ts de Ae eee ee , 2mm DOCU DOCUMENT MMUEMEN N T EDITED PAGE * Gibbs Graham .: KEY WORD OR CHARACTERISTIC Gibbs Graham .; _The geochemistry asbestos from the Eastern Townships Quebec published Geochim__ Geochim__ + Cosmochim Acta 35 425.7 1971 recobe 74 Thisia ----- --- DOCUMEN oe 3503 Location Extractions of selected specimens of chrysotile from the Eastern Townships of Quebec yielded small quantities of organic P mst^llal Infrared and gas chromatographic studies indicate the presence of predominantly alkanes These were probably derived by distillation from Precambrian sediments although a magmatic origin is not completely ruled out Sample collection handling methods of analysis and problems associated with such studies of chrysotile are discussed 2- MCELL FOUN 113 TRACING CARD JHIA 00765 rhe oct 1 of, ee ST ' DIKUMIKE KUMIEM a Je DOCUMENT ku NOITED PAGE or 3502 LOCATION an KEY WORD OR CHARACTERISTIC CHARACTERISTIC SCOPE NOTES S The organic content of Canadian chrysotile American Industrial Hy Ass J. 32 8 519-528 Aug. 1971 | O . COT - 81 43 | 56 60 | j The organic content of commercially milled Canadian duysotile was found to range from 0.5 to 20.0 ing pu 100 gm dipanding dipanding on the spierre and grade of fiber These yid s exceededexce ded those from field specimens in all caset except one and indiested contamination by mining and milling processes An elemental analysis showed the organic extracts to contain carbon 8191 8191 in 1977 lydingen 3147 to 13.1172 and minor amounts of other clements Infrared and gas thiorratogs aphic examination confimal malkanes to be the majn constitucits The concentration of judgetic judgetic stomatic hydhuestions in milled flag was considered top his to play an impritant role ju carcinogenesis The importaure and soutees of malkanes and total organic contamination are discussed x EUNG KETUES KETUES 191 Watt FROM 1130 INDEX TRACING CARO eee JHM 00766