Document 8RQNgjoRRoKMZXnkwGk2EGzae

1 0C00O 1 1 I! '- Hh I smmmm mm iSi^ N36828 CENTRAL RESEARCH DEVELOPMENT DEPARTMENT HASKELL LABORATORY FOR TOXICOLOGY AND INDUSTRIAL MEDICINE TO: M. W. OTT_________________ CHEMICALS & PIGMENTS DEPARTMENT CHESTNUT RUN DATE FEBRUARY 12, 1981 $ JW<%. Lt d INFO pnut MEDICAL RESEARCH PROJECT MS- 40 88 PART I TITLE: SKIN IRRITATION AND SENSITIZATION TESTING OF KROLOR PIGMENTS Authority is requested to undertake the investigation identified above and described as follows: 1. Skin Irritation Test - Rabbits 2. Primary Irritation & Sensitization Test - Guinea Pigs Krolor Pigment 3 Skin Irritation Test - Rabbits Encapsulated Pigment (20% silicate coating) ********* .****************************** Amount requested $3,800 Previously authorized -0-- Expended to date -0- ACCOUNT TO BE CHARGED^ CLASSIFIED: Work to be started upon authorization Request for study made by MWO to G. L. Kennedy, Letter 1/22/81 RED ______________________________OTHER (check appropriate classification) * * * * * ******************* Hr************ If. this request meets with your approval, please enter the account to be charged, the classification, have one copy authorized and return.to Haskell Laboratory, Control Section. The additional copies may be retained for your information and. distributior Proposed by Approved b Authorized 1436828 (date) DUP050308380 CH-3516 <mm> qo** E. 1. d u Po n t E$1AMJSWDW02 d e Ne mo u r s & Co mp a n y INCORPORATED WILMINGTON, DELAWARE 19898 CHEMICALS AND PIGMENTS DEPARTMENT CHESTNUT RUN cc: JMOathout-Tex.Fib.-Old Hickory JFHaywood-Tex.Fib.-old Hickory HJTrochimowicz-CR&D-Haskell Lai DWHoppenjans-C&P--B-6237 RARepetto-C&P-B-6237 HWLing/EWStewart JCWatts MWOtt File January 22, 1981 G. L. KENNEDY CR&D - HASKELL LABORATORY TEXTILE FIBERS TYPAR CARPET BACKING Textile Fibers is using TYPAR spunbonded polypropylene for carpet backing and plans to introduce a brown colored TYPAR in the future. The colorant would be a cadmium based pigment which Textile Fibers purchase as a 50% pigment concentrate in polypropylene resin. At Textile Fibers' request, C&P developed an alternate colorant that could be used. The pigment content of the colorant consists ofi KROLOR Yellow KY-787 KROLOR Orange KO-789 Carbon Black 65% 30% 5% KROLOR pigments are lead chromate or lead chromate/molybdate pigments which have a surface coating (encapsulation) of silicate which is about 20% of the total pigment weight. The pigments would be purchased by Textile Fibers as a concentrate in polypro pylene resin. In this form, it is highly unlikely any airborne exposure to lead chromate would occur. In the final product, the pigment would be present at a level under 0.2% encased in the polypropylene fiber. Textile Fibers is interested in this colorant because of large potential cost savings but is concerned about the testing that would be necessary to qualify this material. Since you have previous experience with lead chromate pigments and are aware of their hazards, I request that you look at the implications of replacing cadmium pigments with lead chromate pigments in TYPAR and what type of tests Haskell would recommend for lead chromate pigments. Skin sensitation tests were suggested for cadmium pigments. Any guidance you can give on this matter will help in deter mining how to proceed with this program. You can contact me at 999-2711 if additional details are needed. /ilc rruff'^nt' M. W. OTT y'S m N36828.02 DUP050308381