Document 8RB2be48B08wLNqVBnzOXqOkK

FILE NAME: Owens Illinois (OWILL) DATE: 1948 Nov 16 DOC#: OWILL040 DOCUMENT DESCRIPTION: Letter from from Dr. Vorwald, The Saranac Laboratory to OWILL A Hoveaber 16, 1943 . . * Hr* J5. Eovoo- ' - ' >*' . ; Ovens-Illinels Gl&ea Company Toledo 1, Ohio ' , /*' Dear Hr* Boveai " Enclosed you vill find three copies of a report on the results of lisutl experiments vith. Eaylo dust* As is oar cu.vtca, ve have easier!red briefly notarial previously presented, including our In terim report dated October 30, 1947, end have given detailed dis cussion only-of subsequent developments*. Vhea all experiments have' been completed, ve expect to prepare a final report "which vill in clude details of esca phase so that all data vill be available in one place. However, the experimental study of the effects of inhaled Kayla dust cn normal uninfected sninala in nov finished and conclusions expressed on that subject are final, m t h e r than tentative. '. In the report issued one year ago, vhich describes the findings "in anlaals that inhaled Saylo dust fer periods up to 30 nonths, the following tentative conclusion van aadex In consequence of the experimental studies vith guinea pigs to determine the biological activity of ; r "Kaylo, it nay be tentatively concluded that Eaylo clone foils to produce significant pulmonary damage vhan In-- ` holed into the lung. During the 30 to 3& nonths period, however, definite indication of tissue reaction appeared in the lun^e of paiaals Inhaling Ksylo dust and there fore, I regret to say, cur tentative conclusion quoted above must be al tered* In ell animals sacrificed after acre than 30 months of exposure to faylo dust unnistaxable evidence of asbeatosia bee developed, showing that Laylo on inhalation Is capable of producing asbestosis and nust be regarded as a potootlally-baaardous material. It should bo noted that eince naither silicosis nor the diffuse pulmonary fibror-ls caused by inhaled diatcm&o-scus earth vaa observed, the quartz and di&tcascecus earth components of tho dust apparently do not produce their typical lesions. Ik order to proseat more infers*ticn on the subject asbestosis, certain evidence derived from our experimental verk vith esboitos dust has been dis cussed* Ao these findings have not yot been reloaded for publication, I re quest that, vhile using then as required in formulating a safety program, you regard them an confidential. Ftge 2. Hr. 0. E. Bowes Ov en s-mi noig Glass Coaosny Koventer 16 1948 Tha nev series of experiments with respect to the influence of Kayla cn tuberculous infection are veil under way and are pro gressing satisfactorily. It is, of course, toe early to expect significant results on vhich to base even tentative conclusions. At this tine cta j I review briefly the financial arrangnent r for conducting the investigation with Kaylo? The research program up to thl3 year ves carried on under n contract, initiated in 1915*. by which the experiaanto would be subsidised vitb a grant of $5,000. per yaar. As pointed out in ~sj letter cf March 3 1948, the contract terminated officially on February 15 1948, but the investigation vould be continued without charge until June because the original experiments were started late. Since a check vts received vhich took care of the subsidy up to November 15, 1947, there is due on the old contract the sust. of $1 ,250. for the final quarter of the contract (from November 15, 1947 to February 15 1948). Vo hare delayed .sending an invoice for tne final quarter until all vork ccold be finished end a final report submittod. Following the termination of the experiment in June, it has required several souths to do the histological vork, study the tissue sections, collate the data and prepare the report vhich accompanies this letter. Vs are including in the report a brief review of the nev experi ments in vhich the effect of inhaled K&ylo dust on tuberculous in fection is being studied. Tour purchar.8 orderAS-170 authorizing this experiment at $5,000. for cne ye-r la dated February 3 1948, but owing to a shortage of animals and other unavoidable delays the actual experi mental vork did not get under voy until May. Hence ve have concluded that financial support for this nev progrtu* should be dated frea May 1, 1948. For reasons outlined in xy letter of March 3 I suggested n twoyear contract at $7,000. per year. lour letter of March 31 acknowledged this but failed to confirm the extra amount of $2,COO. involved. Never theless* ve heve proceeded at the old rat and are endeavoring to absorb the increased cost fres. our Foundation reserve. In a fev days our accounting department will forward a statement of the payments new due in support of the research program, as follows Original exparlaent, begun February 15, 1945 at rate of $5,000. annually For final quarter (lioveabor 1 5 , 1947 to February 15, 1948) $1 ,2 5 0 * Key exr-orimopt. begun Kay 1, 1948, at rate of $5,000* annually For fir.-t quartor (Kay 1, 1948 to August 1, 1948) For second quarter (August 1, 1948 to Hovenfcer 1, 1948) $1,250. j1.253. $3,750, r* K* Bovaa wens-IUlnoia Gina3 Conoanr Koveaber 16. 19A8 I realise that our findings regarding Keylo are lose favorable jan anticipated Her-ever, eince Ksylo is capable of producing aaistosio, It is better to discover it nov in. anlaals rather than later 5 industrial vorkars* thus the company, being forevamed, vill be a better position to institute adequate control measures for eafeairdieg exposed employees and protecting its cvn interests Sincerely yours, TtLB cs* (3) 5: Mr. Dayton Arthur J. Tenfold, M.D. Director