Document 8R9ke0ygEJ0N8YOYROpMdeJL5

FILE NAME Industrial Hygiene Foundation IHF DATE 1957 Dec 30 DOC IHF071 DOCUMENT DESCRIPTION Letter from Manville  08 . Houss MANNILLE GORPORATION GORPORATION TWEES PE TWH EAST LOVELEPIE STREET 7 MENGHIL MENGHIL MENGHIL OWN . ( VI bed IPPINES . re : oe * . me . , . 1 Mr. Ivan Sacourin St. Johns Quebec oo. wees . Re ; I.H.F. Survey Dear Ivan ie " Co eat : . ^'- . . , Hugh Jackson and I have reviewed the condensation of the survey which you sent us We have noted deletion of all references to the association of asbestosis and lung cancer in this condensation While we believe that this in- formation is of great scientific value we can understand the desire of the Q.A.N.A. to emphasize the exposurte he asbestos ziner and not the cases of Asbestosis We also are in agreement with the deletion of the reference to smoking and lung cancer Ty. " . . It must be recognized however that this report will be subjected to criticism when published because all other authors today correlate lung cancer cases of asbestosis If we are to restrict this condensation to asbestos nd\ners, the De the greater conert emphasis should be The fact that all placed the choice of words used in definmembers of the cohort had 5 or more years of exposure to asbestus should be reiterated . .. Followianrge comments on certain Pare 9 one ; , paragraphs of the condensation : We believe the first sentence in paragraph 2 should read Perhaps no , une has written so extensively - = <- = . . lage 14 In the third sentence of paragraph 2 the definition of cohort should te exparted to expresize that exposed personnel were not included in the samplc This eight be done by auding a sentence sigilar the following office and other exposed personnel regardless of length of employment were not included the conart Page 18 : . To further emphasize the exposure aspect of the miners the second sentence of paragraph 2 might read All workers with more than 5 years of ex- youre were placed in one of three categories 11 might be advisable to to add another sentence at the end of this paras paras graph lo previously noted workers with no exposure were not included in the cata - . Page 23 . | , -- tip -- cance signif In the fourth sentence referones is made to the 95 level of This phrase vas explained eleasi and thoroughly on Pages 23 to 25 in an suction original advisable was on Statistical Methods of the deleted in the condensation we feelit survey might be Because this whole sectio to explain by foot- note the meaning of the 95 level of significanca . . Wo feel that the firth sentence right be made stranger by the following change cases However having found just 12 we are not above this level and a therefore the hypothesis that asbestos miners do not have a higher mortalityfrom Ur lung cancer than does the general population cannotbe rejected Fare 41 co - | The table in the center of the page shows a rate of original 271 age group In the survey this rate was 27 in tho 45 - Si Face 48 .- In the last sentence of the first paragraph we would like to to substitution the word undertakes for the word commissioned ay In the second of paragraph 3 we would like to suggest thatthe sentence elnments of the cohort definition be repeated A cohort was as a group defined of asbestos ziners having at least 5 years of exposure in theindstry and who wa in the industry during 1950. Caly these workers who met these criteria were ine cluded in the study suggest phrase In the last sentence of paragraph paragraph paragraph 1 we would like to the dele- tion of the which have been explained in some detail since such explanati was deleted in the condensation Dr. This publication should form the Braun should be asked to establish the basis for futursuerveys surveys and reports framework of reporting for Doctors Grainger and Cartier so that each year the status of every member of the original cohort could be reported to the Industrial Hygiene Foundation and the continuing study be analyzed by their experts We cannot emphasize this point too strong study bocause nowhere in the literature today is there reported reported a valuable and which approximates this magnitude which is so We agree with Doctors Cartier and Braun that a certain number worker probably have some asbestotic fibrosis which cannot be diagnosed by ray U1I. furtunately us cannot take lung biopsies on all workers and we have no other Deans of making a diagnosis before there are ray changes Therefore the study of all exposed asbestes workers becomes increasinglyincreasingly important am We feel that Dr. Braun and his staff are for this very valuable contribution to our medical Y efforts will be rewarded in the near future by the recognized journal to be congratulated knowledge knowledge trust priblication priblicationpriblication of congratulated heartil trust that the work in