Document 8O01OyO6QZkoMmNkra9L42m3o

EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. Report Title PATHOLOGY PEER REVIEW AND PATHOLOGY WORKING GROUP REVIEW OF MAMMARY GLANDS FROM A CHRONIC FEEDING STUDY IN RATS WITH PFOA PWG REPORT Data ReNqIuAirement Jerry F. HAaurtdihsotry, D.V.M. JuneD1a7t,e2005 Performing Laboratory. Experimental Pathology Laboratories, Inc. P.0. Box 12766 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. PATHOLOGY PEER REVIEW AND PATHOLOGY WORKING GROUP REVIEW OF MAMMARY GLANDS FROM A CHRONIC FEEDING STUDY IN RATS WITH PFOA CERTIFICATION OF GOOD LABORATORY PRACTICES This Pathology Working Group Review (PWG) does not constitute a study. Therefore, Good Laboratory Practice Standards (40 CFR, Part 160) do not apply to this report. However, all EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. PWG PARTICIPANTS: JDiEpRlRdmYatF.e ACVPARDISTY, D.V.M\ (Chairperson) GABRIELLEA. WILLSON, B.V.M.S., MACVS F(.RRe.vCi.ewPiantghPathologist) [YN ---- W_RAY BRON, DVM, Ph. Diplomate ACVP (Consulting Pathologist) Fok MeColl ERNEST E. MCCONNELL, D.V.M., M.S. EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. PATHOLOGY PEER REVIEW AND PATHOLOGY WORKING GROUP REVIEW OF MAMMARY GLANDS FROM A CHRONIC FEEDING STUDY IN RATS WITH PFOA TABLE OF CONTENTS Page TITLE PAGE 1 CERTIFICATION OF GOOD LABORATORY PRACTICES 2 PWG PARTICIPANTS' PAGE 3 TABLE OF CONTENTS 4 NARRATIVE 5 APPENDIX A 14 PWG Consensus Diagnoses for Individual Animals Reviewed in Each Group APPENDIX B 19 Statistical Analyses of Mammary Tumors in Rats Fed PFOA APPENDIX C 21 Curriculum Vitae EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. PATPHAOTLHOOGLYOWGOYRPKEIENRGRGERVOIUEPW ARNEVDIEW OF MAMMARY GLANDS FROM A CHRONIC FEEDING STUDY IN RATS WITH PFOA EPL PROJECT NO. 129-060 NARRATIVE SUMMARY INTRODUCTION Hematoxylin and eosin stained and trichrome stained microscopic slides of mammary gland from female rats used in a chronic feeding study in rats with PFOA were received from DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware by Experimental Pathology Laboratories, Inc. (EPL), Research Triangle Park, North Carolina. The study was conducted by the 3M Corporation and the tissues from the study had previously been examined and the results reported by Dr. Robert Geil, the Study Pathologist (SP), for the 3M Corporation. A summaryof the group design according to the protocol for the study is summarized in Table 1 below: Table 1. iEnxFpeermiamleentSaplraDgesuieg-nDafworleayCRhartosniwcitFheePdFiOngA Study Dietary Level of Group No. _ [Test Material (ppm) Number of Female Rats Interim Sacrifice [+Jew | 1s | |e| moo | 0 | [se [Tween | vv | Terminal Sacrifice ow | =| =| Dr. Gabrielle Willson, the Reviewing Pathologist, reexamined all sections of mammary gland from all female rats in all groups, all previously reported mammary EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. `examined microscopically. The purpose of the peer review was to validate the accuracy and Gansistencyof the inital histopathologic examination and to identify the issues that needed to be addressed during the review. The preliminary review of the data indicated that alt masses were sectioned and examined microscopically. Following the reexamination of the histopathology findings of all sections of the mammary gland by the Reviewing Pathologist, a Pathology Working Group (PWG) was convened for the purpose of providing a consensus diagnosis for all neoplastic lesions involving the mammary gland which were diagnosed either by the Study Pathologist or the Reviewing Pathologist. The PWG members consisted of the Reviewing Pathologist, Dr. Willson, and the two consultant board-certified veterinary pathologists with extensive experience in the microscopic evaluation and interpretation of lesions observed in chronic toxicity and oncogenicty bioassay studies conducted in rodents. The original Study Pathologist was not available for the PWG meeting. The PWG's task was to provide a consensus diagnosis for eachof the mammary gland neoplasms reported by either the Study or Reviewing Pathologist and to determine the toxicologic significance of the incidence of mammary gland neoplasms present in the female rats treated with PFOA in the diet. `Conduct of the Reviewing Pathologist's Examination `The mammary gland and all subcutaneous masses were evaluated for histopathologic changes during the Reviewing Pathologist's examination conducted by Dr. Willson. Although all microscopic findings in the mammary gland were reviewed, particular emphasis was given to neoplastic lesions. Al slides containing sections of mammary tissue with a primary neoplasm of the mammary gland diagnosed by either the Study or Reviewing Pathologist were organized for the PWG review. 6 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. Conduct of the Pathology Working Group Review `The Pathology Working Group was chaired by Dr. Jerry F. Hardisty, Experimental Pathology Laboratories, Inc. (EPL), who organized and presented the material to the panel ofthree pathologists. Curricula vitae forthe PWG Chairperson and eachofthe PWG participants are present in Appendix C. The PWG reviewwas performed on May 19, 2005, at Experimental Pathology Laboratories in the Research Triangle Park, North Carolina. Individuals attending or participating in the PWG review are listed below: Dr. Jerry F. Hardisty, Diplomate, AC.V.P. DFr.RCGabPraitehlle Willson, Dr. W. Ray Brown Diplomate, A.C.V.P. DDri.pEl.oEm.atMec,CAonCnePll. (PWG Chairman) (Reviewing Pathologist) (PWG Participant) (PWG Participant) Dr. Steven R. Frame MDri.plGoemraatled,KAeCnVnePdy (Observer) (Observer) `The PWG examined coded slideswithout knowledgeof treatment group. Each participant recorded histher diagnoses and comments onworksheetswhich were prepared by the PWG Chairperson. The PWG examined the mammary gland only for neoplastic lesions and did not consider other lesions which may have also been present. Each lesion was discussed bythe group, reexamined if necessary, and the final opinions were recorded on the Chairperson's worksheets. The consensus diagnoses ofthe PWG were reached when at least twoof the three PWG participants were in agreement. During the PWG review, the nomenclature and diagnostic criteria recommended by the Society ofToxicological Pathologists was used by the PWG to classify the proliferative lesions (Mann, et. al, 1996). A summaryofthe diagnostic criteria and nomenclature used by the PWG participants for prolferative lesions of the mammary gland of rats is presented below: EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. Nomenclature and Diagnostic Criteria for Proliferative Lesions of the Mammary Gland in Rats LOBULAR HYPERPLASIA Dilatationofducts or ductules usually present. Evidence of epithelial or glandular proliferation. May contain mild cellular pleomorphism and mitotic activty. FIBROADENOMA Composed ofglandular epithelium and fibrous connective tissue. Epithelium is generally single layered and uniform and may contain lipid vacuoles. Connective tissue distributed within and between lobules ranges from well-differentiated to dense hyalinized collagen with few interspersed fibrocytes . Epithelium often forms ductules, alveoli or small cysts. Focal areas of atypia and/or cellular pleomorphism may be present Mast cells may be frequent ADENOMA Discrete nonencapsulated mass consists of proliferating alveolar structures in clusters separated by scanty connectivetissue septa. Alveoli have a single layer of low cuboidal to columnar epithelium with small nuclei and a single nucleolus; epithelium often vacuolated. Alveolar lumina may be empty orfilled with minimal secretion (tubular pattern) or may be widely distended by proteinaceous secretion (secretory pattern). Luminal surface ofepithelium generally round, may be smooth or serrated. Focal areas of atypia and/or pleomorphism may be present. EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. May have distant metastases. Neoplastic epithelial cellsfrom 1-4 or more layersthick. Uniform epitheiial cells basophilic to eosinophilic with round to oval centrally located nuclei Chromatin clumped, single small nucleolus. Numerous mitotic figures. Multiple branching papillae covered by cuboidal to columnar epithelium (papillary pattern). Closely packed, generally empty, tubular structures which may be round or elongated (tubular pattern). Neoplastic epithelial proliferation in a solid sheet with theformation of secondary lumina (cribriform pattern). Distended ductules lined by a multilayered epithelium surrounding a central core of necrotic tumor cells (comedo pattern). ADENOCARCINOMA ARISING IN FIBROADENOMA Adenocarcinomatous changewithina fibroadenoma. o Histologic pattern ofibroadenoma componentvariable. Typical histologic appearance ofadenocarcinoma present. Afterthe PWG completed the slide review and the diagnoses were recorded by the PWG Chairperson, the slides were decoded by treatment group. PWG consensus diagnosesfor individual animals reviewed in each group are presented in AppendixA. A summary ofthe incidence of neoplasms in the mammary gland offemale rats istabulated in Table 2 EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. Table 2. Chronic Feeding Study in Female Sprague-Dawley Rats with PFOA: Incidence of Mammary Gland Neoplasms in Female Rats [co1 wt| mse |cms| Iselews[sw [ews|se[enc] em| LelLor [oa Necropsied EE FAERE EAEAEN (16%) 18%) (28%) (32%) EE FAP EAR EA EAE Fioroadenama,Mule(4) [a] s 2 | 3 (16%) (32%) (26%) (32%) (38%) (40%) (12%) (12%) (4%) (6%) (6%) (2%) |No.ofAnimalwin ennTumors | 13 [19|10[22| 1| 29| |toofprimatswineignantrumors| os| 0 |14| 6|5| 5| TESTE Te es SR Se fr sa | [0e] EE FMalEignantTumors a eyDa ap[eepra a ao gem][=[= [=|= (BenignorMalignant)* EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. and malignant neoplasms, the majority ofthe other neoplasms reported by the Study Pathologist were confirmed during the PWG review of mammary gland neoplasms in female rats from this study. Although the incidence of neoplasms varied among the control and treated groups, there were no statistically-significant differences when evaluated using the Fisher's Exact Test for pairwise comparison for fibroadenoma, adenocarcinoma, total benign neoplasms or total malignant neoplasms. The PWG noted that although it is not recommended that benign and malignant neoplasms be combined since there was no histologic evidence of tumor progression from benign to malignant (McConnell, 1986). However, even if combined in this study, there was no significant difference between control and treated groups. The only statistically significant difference (<0.01) involved a negative pairwise comparison in the incidence of adenocarcinoma in Group 6 (30 ppm) compared to Group 5 (300 ppm). Statistical analyses of mammary tumors in rat fed PFOA conducted by Dr. David W. Gaylor are presented in Appendix B. There was no increase in tumor multiplicity or incidence with dose between control and treated groups. The morphologic appearance ofthe neoplasms present in treated groups was similar to those observed in the control groups indicating that treatment did not affect the phenotypeof the neoplasms in the study. The incidence of mammary gland neoplasms observed in this study is similar to historical control data for mammary gland neoplasms in untreated Crl:CD female Sprague-Dawley Rats in 104 week studies in the open literature (Inveresk Research, 2002; Giknis and Clifford, 2001; Giknis and Clifford, 2004; Chandra, et al., 1992; McMartin, et al., 1992; Stevens, et al. 1994; and Sykes G, EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. ADENOMA | FIBROADENOMA |ADENOCARCINOMA| REFERENCE 354% (NA) 18.96% (NA0 |ee8.o80%e(NAow [1092mere 6.5% (29-114%) |31.3% (200-43.3%) | 16.8% (67-300%) |1V9i8c2ari ON, oT al, 1% (07) 33% (36-48) |m1e7% (3:19n|S16e94c,sAtiramzminee | sues 34% (2.75 14% (0-25) S1t09e4v,enPs,roJpTa,rienteal. | 2% @11 |_3o0% (20n-43 |eo1m8%so(s7:30m|e194s,Siimmazianee 4% 031 23% (11:61) 6% (3-18 S19y9k4e,sTGe,rb1u6i8t7h.ylaUzSine "NA =19No%t(a0v9a.i1la%b)le | 374% (242:540%)| 14.1% (6524.5%) | ERePcAorAddm2in2is6tr-a1ti9ve17 CONCLUSION The PWG concluded that the incidence of mammary gland neoplasms in this study was not affected by chronic dietary administration of PFOA. The morphologic appearance, overall incidence and distribution ofthe neoplasms observed in treated and control groups were similar. EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. REFERENCES Chandra M, Riley MGI and Johnson DE (1992) Spontaneous neoplasms in aged SpragueDawley rats. Arch Toxicol, 66: 496-502. Giknis MLA and Clifford CB (2001) Compilationof spontaneous neoplastic lesions and survival in Crl:CD (SD) BR rats from control groups. Charles River Laboratories. Giknis MLA and Clifford CB (2004) Compilation ofspontaneous neoplastic lesions and survival in Crl:CD (SD) rats from control groups. Charles River Laboratories. Inveresk Research (2002) Background Tumour Incidences CD Sprague-Dawley rats. Mann PC, Boorman GA, Lollini LO, McMartin DN and Goodman DG (1996) Proliferative lesions of the mammary gland in rats, IS-2. In Guides for Toxicologic Pathology. STPIARPIAFIP, Washington, D.C. McConnell EE, Solleveld HA, Swenberg JA and Boorman GA (1986) Guidelines for combining neoplasms for evaluation of rodent carcinogenesis studies. JNCL, Vol. 76, No. 2., 263-289. McMartin DN, Sahota PS, Gunson DE, Hsu HH and Spaet RH (1992) Neoplasms and related proliferative lesions in control Sprague-Dawley rats from carcinogenicity studies. Historical data and diagnostic considerations. Toxicologic Pathology, Vol. 20, Number 2, 212-225. Stevens JT, Breckenridge CB, Wetzel LT, Gillis JH and Luempert il LG (1994) Hypothesis. for mammary tumorigenesis in Sprague-Dawley Rats exposed to certain triazine herbicides. JurnalofToxicology and Environmental Health, 43:139-153. SykesG (1987) Two-year Toxicity/Carcinogenicity Sudy of Fluorochemical FC-143 in Rats. US EPA Administrative Record 226-1917. 1-6. EPL EXPERIMENTAL PATHOLOGY LABORATORIES; INC. APPENDIX A PWG Consensus Diagnoses for Individual Animals Reviewed in Each Group HaE | 1| i | 1] | 8 {| 1 22038 | | 3 52 | 1 | Z2Z8 |||2g /5|ea|lae5n/g|ecl2le] leS[of(|2e55|g |e(le52|o l[5o[|5=(Z2|[e5 2g Ss |E|2|g|g E|E|E5|5|2E|E|[21EI2EIS(|E8|E EEEHEREHE 35[8 g|)2|385/28|2/22/820|28/85/85/88|22|22(28|25(88|28|285|52/52|35 |B[388[25[3f|qe|Es2|! 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BREE 9 of | . 2 3 |2ogq gledeEe leEln gedgnaege dngEey "P8E5E BHER EEERE EESEEEEE E EERE E RHEiEEeRdE 65J|MtSh ESeEsSbeeasse S8l8SSSs fla ee8le8S8s88 z { | | 3 | | ii [1He H| IE% 288, | 2gg i| 9 lFie0lzeesBell |iofw e| rBEJSaolEsaSEosisess:|i2]| || 2 | 2 | g x g3z $8e 52. |o :: 8.0. 52 5Ees i5 385 HgEfgrieEEeEtsegleie T< E8E diiEi5i3neEends 2 slglaigle 2g 5% Fedece dos & | | | 3 |, | EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. APPENDIX B Statistical Analyses of Mammary Tumors in Rats Fed PFOA 6/12/05 Statistical Analyses ofMammary Tumors in Rats Fed PFOA David W. Gaylor, Ph.D. Gaylor and Associates, LLC Introduction Female Sprague-Dawley rats were fed PFOA in a chronic bioassay. The incidence of animals with mammary tumors reported by the Pathology Working Group are listed in Table 1. The denominators are the effective numberofanimals at risk (adjusted for survival) as calculated by the National Toxicology Program Poly-3 procedure (Portier and Baler, 1989). Table 1. Incidence of mammary tumors in female rats fed PFOA. Tumor type 0 ppm 30 ppm 300 ppm Adenocarcinoma 9/404 16/434 5/414 Fibroadenoma 18/414 22/411 23/443 Adenoma 1/384 0/385 0/414 Fibroadenoma/Adenoma 19/417 22/411 23/443 Adenocarcinoma/ Fibroadenoma/Adenoma ~~ 24/429 31/447 25/453 Results EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. APPENDIX C Curricula Vitae  PRESIDENJTIEVRERTYEFR.IHNAARRDYIPSATTYHOLOGIST EDUCATIIowOaN:State University, Pre-Veterinary, 1965-1967 Iowa State University, D.V.M., 1971 ACderjtuinfcitedAbsysotchieatAemePrriocfaesnsCorolaltetgheeofScVheotoerlionfarVyetPeartihnoalroygiMsetdsi,ci1n9e7,6 NC State University, 1983 P19R9E8S-EPNrTesePnOtS,ITIPOrNesiAdNenDtEaXnPdEPRatIhEoNloCgEis:t, Experimental Pathology Laboratories, Inc., Research Triangle Park, North Carolina lRaebsoproantsoriibelseifnoVriorvgeirnailalamnadnNaogretmheCnatrolainnda.dirTehceticonomofpcaonnytrsaecrtvreesseboatrhchgopvatehronlmoegnyt cahnedmiucniavle,rsaintdy rceossemaertcihcainnddustthreiessa.fety assessment programsofthe pharmaceutical, 1994-1998. VLiabcoeraPtroersiiedesn,tI,ncO.p,eRreasteiaonrschanTdriPaantghloeloPgairskt,,NEoxrptehriCmareonltianla RlaebsoproantsoiribelseifnorNoorvterhalClarmoalinnaagaenmdenVitrgainndiadirection of pathology research 1678-1994. iDnicr,ectRoersaenadrcPhatThroilaonggilset,PaErxkp,erNiomretnhtCaalroPlaitnhaology Laboratories, NRoerstphonCsairbolleinfaorbtrhaencphroojfecEtPLm.anaRgeespmoennsti,bldeirfeocrtitohne amnidcrtoescchonpiicaclesvuapleuravtiisonioonf of the toxicological studies. Responsibleforthe National Toxicology Program's Pathology P Experimental Pathology Laboratories, Inc. JERRY F. HARDISTY, D.V.M. - Continued PRESENT POSITION AND EXPERIENCE - Continued 1972-1076 Research Pathologist, Veterinary Pathology Branch, Biomedical Laboratory, Edgewood Arsenal, Maryland PDra.thHoalrodgiys.tyDwuarsinag pthriescteipmteeeheinptehrefoUr.Sm.edArgrmoysspraencdepmtiocrrsohsipcoppriocgdriaamgninosVeesteorfinary spontaneous disease and changes produced by experimental procedures in eIxabpoerraitmoernytaalnirmeaslusl.ts.He prepared reports describing and interpreting these: During this time he was principal investigator for the reproductive, mutagenic, teratogenic studies performed at the laboratory. This work consisted of revising uptrieivzieodusatetxhpeerliambeornattaolryp.rotTohceolesxpaenrdimdeenstiaglnidnegsingenweemxppleoryimeedntraelqupirroetdotcholesgtroosbse examination of pregnant female rats and fetuses for evidence of fetal toxicity and teexraamtiogneenesseriisa.llyHseectrtaiionneeddbfieotluogsiecsalfotremcahlnfiocrimaantsitoonsp,erafnodrmtotiemxeadmimnateifnegtsalisnkrealtes,tons for prenatal abnormalities. 1971-1972 AWtatletnedrinRgeeVedteArminyariIannst,itDuitveisoifoRneosfeBairocShensor Research, Or. Hardisty studied the radiographic and morphologic lesions of several WmuasycnuleosRkieselre,tahlediinsveeassteigsaotfedthteheGepartmhaongeSnheseipshearnddDpoogs.sibIlneagsesnoectiiatciroenlawtiitohnsDhr.ip of caatntiemnpethtiop rdeysdpulcaesitah,eieroisnicnoipdheinlciectpharnoousgtehiatissealencdtiuvneubnriteeeddianngcporneoaglrapmrocesses in an PROFESSIONAL MEMBERSHIPS:  E PL Experimental Pathology Laboratories, Inc. JERRY F. HARDISTY, D.V.M. ~ Continued PROFESSIONAL ACTIVITIES: `Standardized System of Nomenclature and Diagnostic Criteria (SSNDC), The Society of Toxicologic Pathologists, 1987-1995 Executive Comittee, The Society ofToxicologic Pathologists, 1994- 1998. Executive Committee Chairman, The Society of Toxicologic Pathologists, 1997-1998. Joint Committee for STPS/ILS! on International Standardization of Nomenclature and Diagnostic Criteria for Toxicologic Pathology, 1994-1995, Co-Chairman 1995-Present. President-Elect, The Society ofToxicologic Pathologists, 1999-2000. President, The Society of Toxicologic Pathologists, 2000-2001. Past President, The Society of Toxicologic Pathologists, 2001-2002. Long Range Planning Committee, American College of Toxicology, 2002. North American Director, International Academy of Toxicologic Pathology, 2002. FDA Clinical Pharmacology Subcommittee ofthe Advisory Committee for Pharmaceutical Sciences, FDA Center for Drug Evaluation and Research, 2003. EDITORIAL REVIEW BOARD: International Agency for Research on Cancer (WHO), Classification of Rodent Tumors, Part I, The Mouse, 1995-2001 Editorial Review Board for Fundamental and Applied Toxicology, Society of Toxicology Board of Publications, 1996-1998. Editorial Review Board for Toxicological Sciences, Society of Toxicology Board of Publications, 1998-2004, Editorial Review Board for Experimental and Toxicologic Pathology, 2000. DEPL" commen JERRY F. HARDISTY, D.V.M. - Continued PUBLICATIONS AND PAPERS - Continued Evaluation of the effects of chemical compounds on the reproductive system of rats. Hardisty JF. Presented at the Biomedical Laboratory Review and Analysis, April 1975. Reproductive studies with quint essence compounds. Hardisty JF, Presented at the Biomedical Laboratory Review and Analysis of Quint Essence, January 1976. Effects of K2/IP mixture on the reproductive system. Hardisty JF and Pellerin RJ. Edgewood Arsenal Technical Report, 1976. Reproductive studies with diisoproplymethylphosphate in rats. Hardisty JF, Pellerin RJ, Biskup RF and Manthei JH. Edgewood Arsenal Technical Report ARCSL TR 77037, May 1977. Quality assurance in pathology. Hardisty JF, Ward JM and Griesemer RA. NCI-NCTR Pathology Workshop, Bethesda, MD, June 1978. Mononuclear cell leukemia in Fischer 344 rats. Hardisty JF. NCI-NCTR Pathology Workshop, Bethesda, MD, June 1978. Quality assurance for pathology in rodent carcinogenesis tests. Ward JM, Goodman DG, Griesemer RA, Hardisty JF, Schueler RL, Squire RA and Strandberg JD. Journal of Environmental Pathology and Toxicology, 2, 371-378, Nov.-Dec. 1978. Neoplasms and pigmentation ofthe thyroid gland in F-344 rats exposed to 2,4diaminoanisole sulfate, a hair dye component. Ward JM, Stinson, SF, Hardisty JF, Cockrell BY and Hayden DW. Journal of the National Cancer Institute, Vol. 62, No. 4, April 1979. Renal carcinogenic and nephrotoxic effects of the flame retardant TRIS[(2,3dibromopropy) phosphate] in F-344 rats and BEC3F1 mice. Reznik G, Ward JM, pEPL' coveree JERRY F. HARDISTY, D.V.M. - Continued PUBLICATIONS AND PAPERS -- Continued Cancer induction following single and multiple exposures to a constant amount of vinyl chloride monomer. Hehir RM, McNamara BP, McLaughlin J, Wiligan DA, Bierbower G and Hardisty JF. Presented for the conference to re-evaluate the ToxicologyofVinyl Chloride Monomer, Polyvinyl Chioride and Structural Analogues on March 20-21, 1980, at the National Institute of Health, Bethesda, MD. Cancer induction following single and multiple exposures to a constant amountofvinyl chloride monomer. Hehir RM, McNamara BP, McLaughlin J, Willgan DA, Bietbower G and Hardisty JF. Environmental Health Perspectives, 41, 63-72, October 1981. Carcinogenesis bioassay of 2,6-Xyidine in rats. Hardisty JF, Montgomery CA and Kornreich M. The Toxicologist, Vol 3, No. 1, March 1983, GChirbosnoincJtEoxiacnitdy HaanrddiosntcyoJgFe.niFcuintydabmieonatsaslayaonfdiAnphpallieeddtToolxuiecnoeloingyF,is3c: h3er153-43419r,at1s.983 Qualty assurance in pathology for rodent carcinogenicity tests, by GA Boorman, CA Monigomery, JF Hardisty, SL Eustis, MJ Wolfe and EE McConnell. In: Handbook of Carcinogen Testing, (H Milman and E Weisberger, eds), pp. 345-357. New Jersey: Noyes Publications,1985. Systemic effects following inhalation offog oil obscurant, Hardisty JF, Stead AG, Grose EC and Selgrade MJ. Presented at the North Carolina Chapter of the Society of Toxicology Meeting on February 2, 1985. Factors influencing laboratory animal spontaneous tumor profiles. Hardisty JF. Toxicologic Pathology , 13, 91-104, 1985. Pulmonary and hepatic health effects of inhalationofpetroleum smoke. Grose EC, Stevens MA, lling JW, Jaskot RH, Hardisty JF and Stead A. The Toxicologist, Vol 6, No.  JERRY F. HARDISTY, D.V.M. - Continued PChUrBoLniIcCtAoTxiIcOitNySanAdNoDncPogAePniEcRiSty--stCuodnyotifn2u,e6ddiethylaniline. TG Pulin, RW Naismith, JF H1a9r8d8i.sty, EB Whorton Jr. and GL Ter Haar. The Toxicologist, Vol 8, No. 1, February MPeorrigpahenraalndneJrAveSwsehenabtehrgt.umIonr:sI,LSrIat,MobnyoDg.rMa.pWhaslkoenr,PaVt.hEo.loWgaylklearb,orJa.tFo.rHyaarndiimsatlys,,KT nervous system, Vol 6, (TC Jones, U Mohr and RD Hunt, eds), New York, Springer- Verlag, 1988. HPautlcmho,naErCyGerfofsecet,sAdGueSttoeasdu,bcFhJroMniilecre,xJpAosGurraehtaomo,ilMfoAg.StMeKveSneslagrnaddeJ,F GHaErdisty. Toxicology and Industrial Health, Vol 6, No. 1, 1990. TBhoyorromiadng,landE,usbtyisJ,FCHaMrodnitsgtyomaenrdy,GMA BEolwoerlmlaann.dIWn: PMaatchKoelnozaiye,ofetdhse),F3S4a4nRDaite,go(,G Academic Press, 1990. OHarradlicsatvyitaynd(phSaLryEnuxst,ist.onIgnu:eP,atgihnogliovgayl toefetthh)e,Fe3s4o4phRaatg,us(GanBdoosrtmoamna,ch, EbuystHisR, BCrown, JF Montgomery, M Elwell and W MacKenzie, eds), San Diego, Academic Press, 1990. ETuosxtiicso.loIgni:cParlopgartehsosloignyT:oxaiccroiltoicgayl,st(0agCelainyssotnu,dy| iMnutnerrpor,etPatSiohnu,bibky aJFndHaJrdSiwsetnybaenrgd,SeLds). Amsterdam, Elsevier, 1990. TUuVmAorrasdioaftitohne.sJkKinDiunntnhieckH,RPA/DSFkohrbmeosu,sSeLaEfutsertitsreaantdmeJnFtHwairtdhis8t-ym.etFhuonxdy.p&soArpapll.enToaxn.d, Vol 16, 92-102, 1991. Proliferative lesionsof the mouse lung: Progression studies in Strain A mice. JF Foley, PPA] JERRY F. HARDISTY, D.V.M. - Continued PUBLICATIONS AND PAPERS - Continued A comparison of ver tumor diagnoses from seven PCB studies in rats. Moore John A, HPahradrimsatcyoJleorgryy,F,VoBla2n0a,s3D6e2-b3o7r0a,h1A99a4n.d Smith, Mary Alice. Regulatory Toxicology and `NTeooxpilcaosltoigcy lReosuinodnstoafblqeueosntiOocntaobbleers3i,gn1i9f9i4ca.nce. Hardisty JF. Presented at the 1994 `UTsoexiocfolnoagsyalRoduinadgtraabmlsetoonreOccotrodbenras4a,l1l9e9s4i.ons. Hardisty JF. Presented at the 1994 Maotrtphheo1l9o8g4icToaxsisceoslsomgeynRtooufndptatahbolleogoincOcchtaonbgeers4,in1t9h9e4.rat larynx. Hardisty JF. Presented PRaotuhnodltoagbylepeienrNarsehvviielwlea,nTdNPoWnG,OctHaorbdeirst2y3,JF1.99P5r.esentedatthe 1995 Toxicology PToexeircorleovgiiecwPiantthooxliocgolyoIgSySpNa.t0h1o9lo2g-y6.23W3a,rVdolJ.M,23,HaNrod.ist2,y 1JF9,85Hailey JR and Street CS. C1o9m9p5uTtoexriiczoeldogpyatRhooulnodgtyadbalteain~Nsaushmvmiallrey, vTs.N ionndiOvicdtuaolb.erHa2r4d,is1t9y95J,F. Presented at the An evaluation of changes in the olfactory epithelium and liver peroxisome proliferation in BmiGc,eDaefreerlainnkhaolaMt,ioRnineexhpaorstuWreEtoanmedthHyalredtihsytlykJeFt.oxTihmee.ToNxeicwotloongisPtE,,VBoollt3e0,HFNo,.La1,kPeart 2, March 1996. TPoexeircorleovgiyew1o7f"hAinsntoupaalthMoeleotgiyngdatian.KiHnagrdoifstPyruJsFs.iaP,rePsAenotnedNoavtetmhebeArme1r1i,c1a9n96C.ollege of Pathology peer review in assessing carcinogenicily studies. Hardisty JF. Presented at WthaeshAimnegrtiocnanonCoDlelecgeemobfeVret5,er1i9n9a6r.y Pathologists' Thiry- First Annual Meeting in Seattle, VPaaltuhoeloofgythIeSmSoN:u0s1e92c.ar6c2i3n3o,geVnoilc.it2y4,biNoo.as6s,ay19(9S6u,mmppa.ry7)2.0-7H2a1r.disty JF. Toxicologic BInltaecrka,ctAiMonDoafhcloenms,taJnFtHsa,rdciosnttyr,acTtGlaTberorrealtl.oriPersesaenndteinddautstIrnyd-usPtarnieall DTiosxcicuoslsoigoincwith HE Pathology, University of linois at Urbana-Champaign, May 19, 1997. TCoonxtircoovleorgsiicaPlaitshsouleosgyi,n Uanniavteormsiitcypoafthloilnooglys.aJtFUrHbaradniast-yC.haPmrpeasiegnnt,edMaatyIn2d0u,st1r9i9a7l. 28  E PL Experimental Pathology Laboratories, Inc, JERRY F. HARDISTY, D.V.M. - Continued PUBLICATIONS AND PAPERS - Continued Phenolphthalein induces thymic lymphomas accompanied by lossof the p53 wild type allele in heterozygous p53-deficient (+) mice. Dunnick JK, Hardisty JF, Herbert RA, Seely JC, Furedi-Machacek EM, Foley JF, Lacks GD, Stasiewicz S and French JE. Toxicologic Pathology, Vol. 25, No. 6., 533-540, 1997. Diagnostic dilemmas in toxicologic pathology. Hardisty Jerry. Presented at The 22 Annual CL Davis DVM Foundation Continuing Education Symposium at North Carolina State University, College of Veterinary Medicine in Raleigh, North Carolina on June 14-18, 1998. Thyroid and parathyroid glands, by JF Hardisty and GA Boorman. In: Pathology of the Mouse, (RR Maronpot, GA Boorman and BW Gaul, eds), Vienna, IL, Cache River Press, 1999. Rodent leydig cell tumorogenesis: a review ofthe physiology, pathology, mechanisms, and relevance to humans. Jon C Cook, GaryR Klinefelter, Jerry F Hardisty, Richard M Sharpe and Paul MD Foster, Critical Reviews in Toxicology, 29(2): 169-261, 1999. The nomenclature of cell death: recommendationsof an ad hoc committee of Society of Toxicologic Pathologists. Levin S, Bucci TJ, Cohen SM, Fix AS, Hardisty JF, Legrand EK, Maronpot RR and Trump BF. Toxicol Pathol. 1999 Jul-Aug;27(4):484-490. Controversial issues in anatomic pathology. Hardisty Jerry. Presented as a course entitled Industrial Toxicologyand Pathologyfor the American Registry of Pathology at the Ramada Inn in Bethesda, MD on September 28, 1999. Histopathology of nasal olfactory mucosa from selected inhalation toxicity studies conducted with volatile chemicals. Hardisty JF, Garman RH, Harkema JR, Lomax LG and Morgan KT. Toxicologic Pathology, Vol.27, No. 6, pp. 618-627, 1999.  E PL Experimental Pathology Laboratories, Inc. JERRY F. HARDISTY, D.V.M. - Continued APUcBhrLoInCicATinIhOalNaStiAonNtDoxiPcAitPyE/oRncSog-enCiocnittyinstuueddy of methylethylketoxime in rats and mice. Newton PE, Wooding WL, Bolte HF, Derelanko MJ, Hardisty JF and Rinehart WE. Inhalation Toxicology, 13:1093-1116, 2001. JCAa,rcCilnaorgeenLJi,cBaasrsneeststmDe,nHtilofdepbrreamnadftloP,xaHcairndiisntryatJsFaannddmLicuec.asWhMiJt.ePKrAe,seDnatneidelaEsMa, Botta posterfor the Society of Toxicologic Pathology and the International Federation of Societies of Toxicologic Pathologists in Orlando, Florida on June 24-28, 2001 Quality review procedures necessary for rodent pathology databases and toxicogenoric Wstautdeiress:WTDh,e HNaartdiiosntayl JTFoxaincodloSiglylsPRrCo.grTaoxmicEoxlp.ePraitehnocle..3B0o,o8r8m-9a2n,G2A0,02.Haseman JK, eInxhpaolsautiroenitnoxFiicsoclhoegry3o4f4ocrtatasm.etBhuyrlncsy-cNloataestrLaAs,ilMoexeaknes(RDG,),fKoollloewsianrgGaB3,-MmaosntthRnWo,seE-lownellly VMoRl, 2H1a,rdNios.ty1,JFppan39d-T53h,ev2e00n2a.z P. International Journalof Toxicology, ISSN 1091-5818, aDinadgnPoastthioclodgiyleCmomuarsseinatnodxiscyolmopgoicsipautmhoilnoCghyi.cPargeos,eInLteodn Jautltyhe,5200In2d.ustrial Toxicology HCiosutrosleo,giRceasrteiafraccths &TridainagglneosPtairck,diNlCemmoans.SePprteesmebnetred8-a1t0,th2e00R2T.P Rodent Pathology Ccaormbpaamraattei-vienpdruecveadlelnivceer,lmeuslitoinpsliciintfyi,veanstdrapirnosgrofesmsailoen moficsep.onTtaaknaehoaushsiaKn,dDviinnysle GE, Foley JF and Maronpot RR. Toxicologic Pathology, Vol 30, No. 5, pp 599-605, 2002. Propylene glycol monomethyl ether (PGME): inhalation toxicity and carcinigenicity in Fischer 344 rats and BEC3F1 mice. Toxicologic Pathology, Vol 30, No. 5, pp 570-579, 2002.  EP L Experimental Pathology Laboratories, Inc. JERRY F. HARDISTY, D.V.M. ~ Continued PUBLICATIONS AND PAPERS -- Continued Histologic artifacts and diagnostic dilemmas. Hardisty JF. Presented at NCTR in Jefferson, AR on October 31, 2002. The pathologist and pathology data. Hardisty JF. Presented at NCTR in Jefferson, AR on October 31, 2002. The pathologist and pathology data. Hardisty JF. Presented at Health Canada in Ottawa, Canada on December 2, 2002. Necropsy and histology techniques. Hardisty JF. Presented at FDA on January 9, 2003. Current approaches to Peer Review and PWG. Hardisty JF. Presented at Battelle in Columbus, OH on June 5, 2003. Characterization of intrathoracic mesothelioma in Fischer 344/N rats. Willson G, Clayton N, Hardisty J, and Pearse G. Presented as a poster for the Society of Toxicologic Pathology, 22TM Annual Meeting In Savannah, Georgia on June 15-19, 2003. Transplacental carcinogenicity of azidothymidine in BGC3F1 mice and F344 rats. Walker DM, Hardisty JF, Ruecker FA, Funk KA, Wolfe MJ and Walker VE. Abstract No. 548. 2004 ltinerary Planner. Baltimore, MD: SocietyofToxicology. Comparison of automated software with conventional histopathology of iver step sections in an NTP Subchronic Bioassay. Willson GA, Joron TA, Lesniak D, Pearse G and Hardisty JF. Presented a poster at the STP Meeting in Salt Lake City, UT, June, 2004. Automated Pathology Systems -- Human Versus Machine Vision. Hardisty JF: Toxicology Roundtable, Augusta, MI. Sept. 2004. EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. GABRIELLE A. WILLSON VETERINARY PATHOLOGIST EDUCATION: GMlRaCsgPoawthUn(iMveermsbietrysVheitperoifnatrhyeSRcohyoaollCBo.lVl.eMg.eS.of, P1a9t7h3ol-o1g9i7st7s), 1985 FRC Path (Fellowship of the Royal College of Pathologists), 1995 PRESENT POSITION AND EXPERIENCE: 01/04 ~ Present. Veterinary Pathologist, Experimental Pathology Laboratories, Inc., Research Triangle Park, NC Provides pathology support to CIIT, Centers for Health Research in Research Triangle Park, on a part-time basis. This involves interaction with staff at al levels and participation in many diverse areas ranging from the technical aspects of tissue processing and necropsy techniques 10 study design, photography, poster preparation, image analysis, confocal microscopy, electron microscopy and immunohistochemistry in addition to the routine necropsy and interpretation of pathological lesions. 09/00 - Present. VReetseerairncarhyTPraitahnoglloegiPsatr,k,ExNpCerimental Pathology Laboratories, Inc., tDiustsiueessafsroamstvaafrfipoautshollaobgoirsattoirnyparneismeanltspaosnidtiaoundiattsEoPfLpaitnhcoluldoegyhidsattoapaatnhdolsopgeicciimnteenrspruetsaetdiofnorof toxicity and carcinogenicity studies. 03/00 - 07/00 Anatomic Pathologist, IDEXX Veterinary Services, West Sacramento, CA EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. GABRIELLE A. WILLSON, B.V.M.S., MRC Path, FRC Path - Continued PRESENT POSITION AND EXPERIENCE - Continued Since August 1991, functioned as a consultant pathologist establishing Histo-Logic, an independent pathology consultancy. Performed pathology on a number of studies and also performed peer reviews of studies for Glaxo Wellcome (Ware). These studies were either performed in house (Ware) or at contractfacilties and of necessity involved close liaison with the other scientists involved. Read a variety of studies in rats, mice, dogs and minipigs for contract and other pharmaceutical laboratories in both the United Kingdom and elsewhere in Europe. Histo-Logic was accepted into the United Kingdom Department of Healths GLP Compliance programme. 10/77 - 06/91 Senior Pathologist, Unilever Research, Shambrook, Bedford UK Responsbilities included postmortem and histological assessment of short, medium and long- term tests in rodents. Acted as Study Director for all teratogenicity studies for several years conduced both in house and at contract laboratories. Management of the Teratology Department with direct responsibility for a staff of four. Achievements During This Period: Completion of a large number of tests encompassing feeding, inhalation, intratracheal instillation, intrapleural and intraperitoneal injection, intravaginal instillation and topical application. Ultrastructural examination and histochemical assessment were frequently required as part of the evaluation process. EPL EXPERIMENTAL PATHOLOGY LABORATORIES, INC. GABRIELLE A. WILLSON, B.V.M.S., MRC Path, FRC Path - Continued PRESENT POSITION AND EXPERIENCE - Continued 0777-1077 Locum work, Henderson & Keywood Veterinary Surgeons Surbiton, surrey UK Locum work in a busy small animal practice. Duties included consultations, surgical procedures, etc. PROFESSIONAL MEMBERSHIPS: Fellow of the Royal College of Pathologists British SocietyofToxicological Pathology Charles Louis Davis, D.V.M. Foundation Society ofToxicologic Pathology PRESENTATIONS AND POSTERS: Induced Mesothelioma in theWistar Rat. Wilson, G, presented at the Industrial Histology Discussion Group, 22nd Meeting, Llandudno, North Wales, September 1992. Spontaneous and Induced Pathology of the Salivary Glands and Oesophagus. Willson G, presented at the BSTP Modular Education Programme in Toxicological Pathology, Cambridge, England, July 20, 1993. Cardiovascular System: Spontaneous Rodent Pathology. Willson, G., presented at the BSTP 2M0o0d1u.lar Education Programme in Toxicological Pathology, Cambridge, England, July 8-12, Hepatoblastomas in Mice in the US National Toxicology Program (NTP) Studies. Turusov VS, EPL PERERAPATHOLOGYTASORATORESTG `GABRIELLE A. WILLSON, B.V.M.S., MRC Path, FRC Path - Continued PUBLICATIONS AND PAPERS: Comparison of Automated Pathology Software with Conventional Histopatholoogfy Liver Step Sections in an NTP Subchronic Bioassay. Willson GA, Joron TA, Lesniak D, Pearse G and Hardisty JF, presented a poster at the STP Meeting in Salt Lake City, UT, June, 2004. tMhoeduplreog1r3a:mMmues)c,ulBoSsTkePleMtoadlulSyasrtEedmu,caSktiino,n SPurbocugtriasmamnedinMTaomxmicaorloygiGclaalndP.atWhiolllosgoyn,GCa(mobrrgiadnigzee,d England, July 5-9, 2004. Corneal Lipoidosis in a Dog with Bilateral Thyroid Carcinoma. Harrington GA and Kelly DF. Vet Pathol. 1980 Jul;17(4):490-3. A Lymphomatoid Granulomatosis of the Lungs in Young Dogs. Lucke VM, Kelly DF, Harrington GA, Gibbs C and Gaskell CJ. Vet Pathol. 1979 Jul:16(4):405-12. Hepatoblastomas in Mice in the US National Toxicology Program (NTP) Studies. Turusov VS, Torii M, Sills RC, Willson GA, Herbert RA, Hailey JR, Haseman JK and Boorman GA. Toxicologic Pathology, Vol. 30, No. 5, pp 580-591. CURRICULUM VITAE - 2004 NAME W. Ray Brown, D.V.M., Ph.D. Diplomate, American College of Veterinary Pathologists PRESENT POSITION Consultant in Toxicologic, Pharmacologic & Experimental Pathology President, Research Pathology Services, Inc. 438 East ButlerAvenue, New Britain, PA 18901 Telephone: 215-345-7070 Fax: 215-345-4326 e-mail: WRBRPS@concentric.net EDUCATION Degree Year Pennsylvania State University University Park, Pennsylvania New York State College of Veterinary Medicine Cornell University Ithaca, New York New York State College ofVeterinary Medicine Cornell University - Veterinary Pathology Ithaca, New York BS 1961 DVM. 1964 PhD. 1967 PREVIOUS POSITIONS Independent Consultant in Toxicologic, Pharmacologic and Experimental Pathology 1973 - present Director of Toxicology and Pathology Merck Institute for Therapeutic Research West Point, Pennsylvania 1972-1973 Director of Pathology 1970-1972 Curriculum Vitae -2004 W. Ray Brown, D.V.M., Ph.D. PREVIOUS POSITIONS (Continued) Laboratory Instructor, Veterinary Pathology New York State College ofVeterinary Medicine Cornell University Ithaca, New York NIH Trainee in Veterinary Pathology New York State CollegeofVeterinary Medicine Cornell University Ithaca, New York ACADEMIC AFFILIATION Assistant Professor, Department of Pathology Jefferson Medical College `Thomas Jefferson University Philadelphia, Pennsylvania PROFESSIONAL SOCIETIES American College ofVeterinary Pathologists American Veterinary Medical Association Pennsylvania Veterinary Medical Association International Academy of Pathology American SocietyofVeterinary Clinical Pathologists Society ofToxicology Society ofToxicologic Pathologists International Union of Pharmacology (Section of Toxicology) Charles Louis Davis, DVM Foundation Sigma Xi Phi Zeta National Veterinary Honorary Society 1964- 1967 1964- 1967 Curriculum Vitae - 2004 'W. Ray Brown, D.V.M., Ph.D. CONTINUING EDUCATION/PROFESSIONAL MEETINGS American College ofVeterinary Pathologists Annual Meeting Baltimore, MD - October 31-November 3 1989 Mouse Pulmonary Carcinogenesis Symposium National Toxicology Program - NIEHS Research Triangle Park, NC - March 27-28 1990 Society of Toxicology Annual Meeting Miami Beach, FL - February 12-15 1990 American College ofVeterinary Pathologists Annual Meeting Phoenix, AZ - December 10-13 1990 Society of Toxicology Annual Meeting Dallas, TX - February 25-28 1991 Drug Information Association Recent Considerations on the Design, Interpretation and Evaluation of Rodent Carcinogenicity Studies Rockville, MD - September 30-October 1 1991 American CollegeofVeterinary Pathologists Annual Meeting Orlando, FL - December 9-13 1991 WC.urRraicyuBlruomwVni,tDa.eV-.M2.0,04Ph.D. CONTINUING EDUCATION/PROFESSIONAL MEETINGS (Continued) Society of Toxicology Annual Meeting New Orleans, LA - March 15-19 1993 Society of Toxicologic Pathologists XIl International Symposium Regulations Governing Toxicologic Pathology Washington, DC - June 27-July 1 1993 Growth Factors and Tumor Promotion: Implications for Risk Assessment (7" International Conference on Carcinogenesis and Risk Assessment) Austin, TX - December 1-4 1993 International Life Sciences Institute 5" Workshop on Mouse LiverTumors Arlington, VA - November 7-9 1994 Society of Toxicology Annual Meeting Baltimore, MD - March 5-9 1995 Society of Toxicologic Pathologists 14" International Symposium San Diego, CA -June 11-15 1995 Staging of Rat Testes Two-day short course by Dr. L. Russell Rohm and Haas Company Spring House, PA - February 26-27 1996 WC.urRraicyuBlruomwnV,itDa.eV-.M2.0,0P4h.D. CONTINUING EDUCATION/PROFESSIONAL MEETINGS (Continued) Society ofToxicology Annual Meeting Cincinnati, OH - March 8-13 1997 Society of Toxicologic Pathologists 16" International Symposium Toxicologic Pathology of the Kidney and Urinary Bladder Beaver Creek, CO -- June 22-26 1997 American College of Veterinary Pathologists Annual Meeting Albuquerque, NM -- November 16-21 1997 Society of Toxicology Annual Meeting New Orleans, LA - March 14-18 1999 Society of Toxicology Annual Meeting Philadelphia, PA - March 19-23 2000 Society of Toxicology Annual Meeting Nashville, TN - March 17-21 2002 Charles Louis Davis, DVM Foundation Alternatives to the Rodent Biosassay in Assessing Carcinogenicity New Brunswick, NJ - April 5 2002 Curriculum Vitae - 2004 W. Ray Brown, D.V.M., Ph.D. CONTINUING EDUCATION/PROFESSIONAL MEETINGS (Continued) Charles Louis Davis, DVM Foundation Gastrointestinal Toxicologic Pathology New Brunswick, NJ - April 25 2003 PATHOLOGY WORKING GROUP (PWG) PARTICIPANT National Toxicology Program -Dioxin- sRteu-deyva(l1u9a9t0i)on of hepatic tumors from the 1978 Kociba rat -Dioxin- Participant at the Banbury Conferences (Cold Spring Harbor) on the resus of the re-evaluation of the rat liver tumors (1990) -PCBs-Re-evaluation ofthe rodent iver tumors from the Aroclor 1254 and 1260 and Clophen A30 and ABO chronic/onco- ~Several industgreinailc-istpyornastorsetdudPieWsG(s19o9n1)chemicals, agrochemicals and pharmaceuticals HISTOPATHOLOGY PEER REVIEW Peer review of histopathology slides and data have been and are being performed for several domestic and international pharmaceutical and chemical companies, trade groups, and consortiums on toxicity and carcinogenicity studies. EXPERIENCE IN TOXICOLOGY AND PATHOLOGY Activities as a consultant in toxicologic and pharmacologic pathology have included the design, supervision, evaluation, and reporting of toxicity and carcinogenicity studies involving various chemical and potential therapeutic or biologic substances. Laboratory WC.urRraicyuBlruomwnV,itDa.eV-M2.0,04Ph.D. Reporting of the above data has included preparation of summarizations of the methods and results, conclusions, and safety assessment of the various agents based on the results. These reports are written in appropriate formats for submission to international and domestic regulatory agencies, e.g., suitable for submission for Investigational New Drug (IND) and New Drug Application (NDA) with the Food and Drug Administration, U. S. Department ofAgriculture, National Cancer Institute and Environmental Protection Agency. In addition to primary project participation and monitoring, peer review experience has included selection as the Society of Toxicology Task Force pathologist to perform an independent pathology review of the urinary bladder and hepatic neoplasms in the FDAINCTR ED; mouse carcinogenicity study and participation in several select panels and committees for review and interpretative opinions on pathology slides and data for various sponsors, as well as international and domestic regulatory agencies. Many ofthese reviews and representations have involved findings and interpretation of hepatic and endocrine toxicity and potential oncogenicity. Curriculum Vitae - 2004 W. Ray Brown, D.V.M., Ph.D. PUBLICATIONS: 1. Christian, M.S. and Brown, W.R., Control Primordial Follicle Counts in Multigeneration Studies in CRL Sprague-Dawley ("Gold Standard") Rats, Toxicologic Sciences, 66:1-S, 233 (2002). 2. York, RG, Brown, WR, Girard, MF. and Dollarhide, J.S., Two-Generation Reproduction Study ofAmmonium Perchlorate in Drinking Water (in press). 3. Cruzan, G., Cushman, JR. Andrews, LS., Granville, G.C., Johnson, KA., Bevan, C., Hardy, CJ. Coombs, DW. Mulins, PA and Brown, WR. Chronic ToxicitylOncogenicity Study of Styrene in CD-1 Mice by Inhalation Exposure for 104 Weeks. J. Applied Toxicology21:185-198 (2001). 4. Cruzan, G., Cushman, JR. Andrews, LS. Granville, G.C., Johnson, K-A., Hardy, C.J., Coombs, DW., Mullins, P.A. and Brown, W.R., Chronic Toxicity/Oncogenicity Study of Styrene in CD Rats by Inhalation Exposure for 104 Weeks. Toxicol. Sci. 46:266-281 (1998) S. Forbes, P.D., Takizawa, T., Hashimoto, K., Yamashita, S, Hoberman, AM., Sambuco, CP. Brown, WR, and Parker, RM. 78-Week Photocarcinogenesis Study of Grepafloxacin and Comparator Articles Administered Orally to Hairless Mice. Toxicological Sciences, 42:1-5, 50-51, 1998. 6. Sambuco, C.P., Powers, W. J., Dempster, M., Hoberman, AM., Forbes, P.D., Brown, WR, Stahle, PL, Streeter, AJ. and Parker, RM. 13-Week Subchronic Phototoxicology Study of levofloxacin, A Quinolone Antibiotic, Administered Orally to Hairless Mice. Toxicological Sciences, 42:1-S, 51, 1998. 7. Parker, RM., Powers, W.J., Dempster, AM., Hoberman, AM., Sambuco, C.P., Brown, WR. Stellar, SM., Streeter, AJ. and Forbes, P.D., 120Month Oral (Gavage) Photocarcinogenicity Study of Levofloxacin in Hairless Mice. Toxicological Sciences, 421-5, 51, 1998. 8. Manley, A. Brown, W.R., and Mennear, J.: Dichlorvos and Mononuclear Cell Leukemia in Fischer 344 Rats: Lack of Effect of Chronic Administration on Progression of the Curriculum Vitae - 2004 'W. Ray Brown, D.V.M., Ph.D. PUBLICATIONS (Continued) 12. McGee, J. H., Butler, W.H., Wiligan, D. A, Brown, W. R., and Sofia, R. D.: Critique of the Toxicology and Carcinogenesis Studies of lodinated Glycerol in F344/N Rats and BGC3F1 Mice. Regulatory Toxicology and Pharmacology 18, 169-180 (1993). 13. Newberne, P. M., Carlton, W. W., and Brown, W. R.: Histopathological Evaluation of Proliferative Liver Lesions in Rats Fed trans-Anethole in Chronic Studies. Food and Chemical Toxicology 27(1): 21-26 (1989). 14. Hagan, J. V., Fisher, J. R., Brown, W. R. and Baldwin, R. C.. Comparison of the TwoWeek Whole-Body and Nose-Only Inhalation Toxicity of Mancozeb in Rats. The Toxicologist 7(1): 196 (1987), 15. Mizens, M., Brown, W. R., Laveglia, J., Killeen, J. C. and Ignatoski, J. A.: Combined 30Day Feeding Study and One-Generation Reproduction Study in Rats with Ethyl 5Cyano-3,4-Dipheny}-6-OXO-1(6H]-Pyridazine-acetate (DS-29399). The Toxicologist 4:17 (1984). 16. Ford, W.H.,Auletta, C. S., BrownW,.R, Laveglia, J,. Killeen, J. C. and Ignatoski, J. A: A 30-Day Toxicity Study in Dogs with Ethyl 5-Cyano-3,4-Diphenyl-6-OXO-1[6H]- Pyridazine-acetate (DS-29399). The Toxicologist 4:18 (1984). 17. GongwerL,. E., AulettaC,.S.,Rinehart, W. E., and Brown, W. R.: Mannitol Il: Lifetime Feeding Study of A-132-1320 in Three Strains of Female Rats, Report of ICI Americas, Inc., Wilmington, DE and Bio/dynamics, Inc., East Millstone, NJ. Docket No. 74-21185 (4 volumes), Dockets Management Branch, FDA, Rockville, MD (1978). 18. Emery, J. B., House, J. A., and Brown, W. R.: Cross-Protective Immunity to Canine Adenovirus Type 2 by Canine Adenovirus Type 1 Vaccination. American Joumal of Veterinary Research 39(11): 1778-1783 (1978). 19. Goldlust, M. B., Rich, L. G., and Brown, W. R.: Immune Synovitis in Rabbits. Effects of Differing Schedules for Intra-articular Challenge with Antigen. American Journal of Pathology 91(2): 329-343 (1978). 20. Apostolou, A., Saidt, L., and Brown, W. R.: Effect of Overnight Fasting of Young Rats CWu.rRraiycuBlruomwVni,taDeM- .2004Ph.D. PUBLICATIONS (Continued) 24. Watson, L. S., Riley, R. L., Connelly, M. T., Russo, H. F, Brown, W. R. and Baer, J. E.: The Electrolyte Excretion Pattern of Amiloride Following Ureteral Retrograde Intraluminal Injection. Federation Proceedings 30: 337 (1971). 24. VanArman, C. G., Carlson, R. P., Brown, W. R. and Itkin, A.: Indomethacin Inhibits the Local Schwartzman Reaction. Proceedings of the Society for Experimental Biology and Medicine, 134(1): 163-168 (1970). 25. Whitlock, R. H. and Brown, W. R.: Chronic Cholangiohepatitis in the Dairy Cow. Cornell Veterinarian LIX(4): 515-524 (1969). 26. Brown, W. R., Krook, L. and Pond, W. G.: Atrophic Rhinitis in Swine. A nutritional disease. Der Tierzuchter 20: 546-647 (1968). 27. Scott, M. L., Olson, G., Krook, L.,Brown, W. R.: Selenium-responsive Myopathies of Myocardium and of Smooth Muscle in the Young Poult. Journal of Nutrition 91(4): 573583 (1967). 28. Brown, W. R., Krook L., Pond, W. G.: Atrophic Rhinitis in Swine. Etiology, Pathogenesis and Prophylaxis. Comell Veterinarian LVI, Supplement No. 1, 1-128 (1966). 29. Brown, W. R., Krook, L. and Pond, W. G., A New Look at Atrophic Rhinitis. Modern Veterinary Practice 47(9): 33-45, August 1966. 30. Krook, L., Pond, W. G. and Brown, W. R.: Dietary Calcium and Phosphorus and Atrophic Rhinitis. |. Nutrition. Proceedings of the 57" Annual Meeting of the American Society forAnimal Science. J. Animal Science 24: 892 (1965), 31. Pond. W. G., Krook, L. and Brown, W. R.: Dietary Calcium and Phosphorus and Atrophic Rhinitis. Proceedings for the 1965 Comell Nutrition Conference for Feed Manufacturers. Buffalo, New York (1965). Book Chapter 1 June 2003 CURRICULUM VITAE Name: Er3n0e2s8t EE.thMacnCoLnanneell, DVM, MS (Path) Raleigh, NC 27613 Date & Place ofBirth:OrNrovivlelme,beOhri1o4,1937 Citizenship: United States Education: 11995557 -- 11996517 -- PD.rVe.vMe.t,erTihnearOyhMieodiSctiantee,UTnihveerOshiitoy State University 1964 - 1966 - M.S, Department ofPathology, Michigan State University `Was1h9i6n5gt-on1,96D7C- Resident, Veterinary Pathology Division, Armed Forces Institute ofPathology, `BoardCertification: DDiipplloommaattee,, AAmmeerriiccaannBCoolalredgeofoTfoVxeitceorliongayr,y1P9at8h0ologists, 1968 `BCriehf ronoofElmpoloygmenyt: Jun 1961 - Aug 1961 Small Animal Practitioner, Becker Small Animal Hospital, Columbus, OH Aug 1961 - Aug 1961 First Lieutenant, USS. Air Force, Gunter AFB, Montgomery, Al Oct 1961 - Sep 1964 Base Veterinarian, Hill Air Force Base, Ogden, UT Sep 1964 - Sep 1965 Graduate Student, Department of Pathology, Michigan StateUniversity, East Lansing, MI LabA,ug 1972 - Aug 1974 CWhriiegfh,tP-aPtahtotleorgsyonBArFanBc,hO,HToxic Hazards Div. 6570 Aerospace MedicalResearch PathAoulgog1is9t74an-dNov 1978 VeterinaryPathologist (Grade 05), UsS. PublicHealth Service, Research Head, Comparative Pathology Section, National Institute of EnvironmentalHealth Sciences (NIEHS), Research Triangle Park, NC. ToxNicoovlo1g9y78 - Jan 1984 VeterinaryDircctor (Grade 06), NIEHS, Chic, Chemical Pathology Branch, Research and Testing Program, ResearchTriangle Park, NC Sep 1983 - Jan 1985 VeTteesrtiinnagrPyrDoigrreacmt,orRe(sGeraadrech06T)r.iaNnIgElHeSP,arAkc,tiNnCgDirector, ToxicologyResearchand andJan 1985 - Oct 1988 VeterinaryDirector (Grade 06). NIEHS, Director, DivisionofToxicology Research TestingProgram, Research Triangle Park, NC Oct 1988 - present President, ToxPath, Inc, 3028 Ethan Lune, Raleigh, NC MilitaryService: A`Auugg 1197641 -- AOcutg11998784:: UU.SS,. APiubrliFcorHceealth Service CurrentSocietyMemberships: `AAmmeerriiccaann AVestseorciinaatriyonMefdorictahleAAsdsvoacinacteimoennt ofScience ``AAmmeerriiccaann CBoolalredgeofofToVxeitceorliongayry Pathologists `ACmoenruimciasnsiRoengeidstOrfyfoicferPsatAhsosloocgiya,tiAoFnI,PUS. Public Health Service NSoocritehtyCaorfoTloixniacCohlaopgtyer of the Society ofToxicology Society ofToxicologic Pathologists PUSaSn.ePlubsliScpeHaekaelrt,hCOountfsetraenndciengonSetrhveicIempMleidcaalt,ioNnIsH,ofWtahsehiBnhgotpoanl,TDrCa,ge1d9y8,5The Workers Policy Project. NewarJke,rsNeey,wMarch 1955 P"TaanscklFMoermebeeLre,adIeAr,RCStWuodrykoifngChGermoiucpalonTrtahcekiEnvgalAugaetniotno(NfPPtDh)e uCasrecdinboygetnhiecSRoivsikeotfKGCBh,emMiocsacloswt,o.1085 HumanSsom+e Chemicals Used in Plastics and Elastomers, Lyon, France, June 1985 SBtouadryd DMiermebcetorr,fAomretrhiecNaTnPBoMaertdhyolfITsooxciycaonlaotgey,St1u9d8y3,-11998859 PPaannecll MMeemmbbeerr,, IReAfRrCacWtoorrkyiCnegraGmriocupFiobnertAhneiEmvaalluSattuidoincso,fTtIhMeAC,ar1c9i8n6ogenic Risk ofChemicals to `Huma`nasnd-SSiolmicea Silicates, Lyon, France,June 1986 CanPcaenrelRiMsekmsber, DHHS Committee 10 Coordinate Environmental andRelated Programs "Report on Pre`sAisdseoncti,atAemdewriitchanthBeoIanrgdesotfiToonxoifcoAlsobgeys,to1s9"8,7-1198978.8 LonPdaonnc,lEMnegmlbaendr,, Health Consequences ofOccupational Exposure to Man-Made Mineral Fibers, TIA, PanJealnuMaermybe1r9,87JARC Working Group to update JARC Monographs: Chemicals and Industrial Processes Assodi`aCtanecdewritihn,Humans, Lyon, France, March 1987 meVicme Cbhaeirmran,RIaApRpCoWorrtk,ingICGSro/uMpARonCMTaank-MGardoeupMienecrtailoFniboersNandMRaaddeonM,inLeyroanl, FFreansc,e,LJounndeo,n1,987 anSde,ptember 1987 PDainsetlinMgeuimsbheerd,ANlautminonuasl,RCeoslelaergcehoCfoVuentceirli,nBaroyarMdedoinciEnnev,iTrohnemOehnitaolStSattuediUensivaernsditTyo,xiJcuonleo,gy1,988 Subco"mAmniitmtaelesoasnMonitors of Eavirommental Hazards", 1987-1989 CCoon-sCuhlatiarnmta,nS,ARBev(iDeriwnokfinEgPWAatCeanrcCeormAmsistetsesemeanntd EGunivdierloinnmees,nt1a9l8H8e-a1l9t8h9Committee, Environmental Protec1t9i8o8n.Agency, ToxMiceomlboegry,, Committee on Toxicology, National Research Council, Board on Environmental Studieson PPaanneell MMeemmbbeerr/,RaEpPpAoSrcaiteenucre,AdIvPiCsSo/rMyABRoKarTda,sDkioGxrionuRpeMveieetwinCgomomniPthtoesege(nHeea,lLthonPdaoncnl,),En1g9l9a5nd, March, 199P6a.nel Member, IPCS/MARK Task GroupMeeting on Chloroethers, London, England, March, 1996. "ToxPiacnocllogMiecmablearn,dNational Research Council, Commission on Life Sciences, Subcommittee on `anPcelrfMoermmbaenrc,eEAPsApeScctisentoiffiOcsyAdgveinsaotreydBMooatrod,rVCeohmimciltetFeueelso'n,E1n0v9i6ronmental Health, Ad Hocmemberfor PanNeelurMteomxbiecro,loEgPyAGuFiodoeldiQneusa;liCtyhaPrro-teTchtyiroonidAcCtarAcdivniosgoernyesBiosarGdu,id1e9l9i6nes, 1996 MPaenmcbleMre,mIbLeS]r,RiEsPkAScSiceinecneceInAsdtviitustoeryWoBrokairdn,gEGPrAouPproopnosDeodseGuSiedleelctiinoens,f1o9r9C6arcinogentc Risk AssPeasnsemlenMte,mb1e9r9.7 IPCS Workshop on Issues in CancerRisk Assessment. Hannover, Germany, January 1998 Jaannduary, 1999. 199`9C.oChalr, EPA SAB/SAP Joint Meeting `Testingof Pesticides fn Human Subjects', Dec 1998 and Nov CPaonCehlaiMre,mEbPeAr,SANaBt/iSoAnPalJoRiensteMaerecthiCnogun"cEinld,ocCroimnmeiDsissiruopntoorns'L,ifMeaSrccihen1c9e9s9,.Subcommittee on "Review of the UsNavy's Exposure Limits for Manufactured Vitreous Fibers", 1999-2000. 1999I.nvited Expert Testimony on Trichloroethylene, Australian SolicitorGeneral, Melbourne, Australia,Nov. PanReelguMleamtbienrg,ToIbntaecrcnoatPiroondaulcCtso"n,feOrselnoc,eNoorfwtahye,WFoerblrduaHreya,lt2h00O0r.ganization. "Advancing Knowledge on theModerator, 2000 SocietyofToxicology "Issue" Session, "The Value andEthics ofUsing;Human Data for ChaRierg,isRtervaiteiwonofofthPeesTtoicxiidceosl"o,gPyhiPlraodgcrlapmhi,a,LoPvAe,laMcaercRehsp2i0r0a0t.ory Research Institute, Albequerque, NM, ApriRlap2p0a0t1our, ILS] Agricultural Chemical Safety Assessment, Workgroup #1, April, 2001. MaySe2s0s0i1o.n Chair, Risk Assessment Methods, "2001 Asbestos Health Effects Conference", Oakland, CA, MMeemmbbeerr,, ALoTvSeDlaRceExRpeesrptirPaatnoerlyoRnesHeeaarlcthh EInfsfteicttusteo'fsA"sRbeessetaorschanPdroSgyrnatmhestOivceFrisbiegrhst(SCVoEm:miTthteeIen'f,l2u0en0c2e-of Fiber Length. Medical Research Council of Canada, 1982-1984 Environmental Health Perspectives, 1983-1990 Drug and Chemical Toxicology, 1986-1994 Fundamental and Applied Toxicology, 1989-1995 Inhalation Toxicology, 1995- Reviewer: Science Annals of Occupational Hygiene Toxicological Sciences. PapasPublished: 1. McConnell, EE: Case for diagnosis. Yaba monkey virus.MilitaryMedicine 132:838, 869, 1967. 2T.o6MscConnell, EE: Garner, F.M. and Kirk, JH.: Hartmanellosis in a bull.PathologiaVeterinaria 5:1-6, 3. McConnell, EE., Cashell, 1G. and Garner, FM: Visceral leishmaniasis with ocularinvolvement in a dog. JAVMA 156:197-203, 1970. D4.huMccoCsoanonfelal,shEeEe.p, oVfanpoRsesnisblbeurign,fe1cBt.iJ.ouasnodriVgiann.1WA5y.k,fJ.A.r: AViceatseMcoofd.aadAesnsnoocca.r4c1i:n9-o1m2a,o1f9t7h0e. olfactory 5. Van Rensburg, 1B.]., Roos, C.J. and McConnell, EE: Diverticulosisin a cow. LAS.friVect.aMend. Assoc. 41:76, 1970. 6V.et.BoMsemda.nA,ssP.oPd.,, MEc1C3o4nn,el1l9,70E.E. and Schutte, AP: Bovine abortion cabuyAssperegildlus sp.1S.African 7. McConnell, EE. and Tustin, R.C.: Pancreatic calculi in a cow.1A5. frViet.Mced,aAssnoc. 41:352, 1970. 8. McConnell, EE. DeVos, A.J., Basson, P.A. and deVos, V.: Isopora papionins. sp. (Eimeriidac) of the Chacma baboon Papio ursinus (Kerr, 1972). I. Protozool. 18:28-32, 1971. 9. McConnell, EE., Van Rensburg, 1B.]. and Minne, J.A.: A rapid test for the diagnosis of strychnine 5(14A8.c2aCr1oi8fnfa5e:1eH,9a0GlMo,r.a,1c9Vh7na1in.daAcs)weagnedna, nPeIwM.r,eMcocrCdonfnreolml,tEheE.ChanadcmBaasbsaobno,oPnA.:ZDeescriipttiFounrsoAfncagnewehawnnrdatsaeilZomgifltoegtie 15. McConnell, EE, Basson, P.A. and deVos, V.: Nasal acariasis in the Chacma baboon (Papio ursinus, Kerr, 1972). Onderstepoort1 Vet. Res. 38:207-214, 1971. 16. Coffee, GM. and McConnell, EE: Pneumonyssus vocalins. sp. (Acarina: Halarachnidac) a new mite: Zforoolmogtiheel5a8r:y2n6g5e-a2l70ve,nt1r9i7c1l.es of the Chacma baboon (Papio ursinus, Kerr). ZeitsFucrahngrewianfdtte. u1r7s.iBnaurst,scKhe,rrR,.C1.9,72W)e.ssLealbsA,pBi.mC.alasnd6:M4c1C-o4n7n,e1l9l7,2.EE: Myocardial tuberculoma in a Chacma baboon (Papio 6178.8.M6c8C2o,nn1e9l7l2,.EE., Basson, P.A. and deVos, V.: Laryngeal acariasis in the Chacma baboon. JAVMA 161: K19r.ugMecrCoNnanteiloln,alEEP.a,rkT.usLAtSi.n,fR.Cr. ainVdetdc.eVMoeasd,.VnA.:ss,Aonct.h4r3a:x1i8n1-a1n87A,fr1i9c7a2n.buffalo (Syncerus caffer) in the 20. McConnell, EE., Basson, P.A., Thomas, SE. and deVos, V.: Oocysts of Isospora Papionis in the skeletal muscles of chacma baboons. OndersteJp.Voeto.Rrets. 39:113-116, 1972. 21. McConnell, EE, Basson, P.A., Wolstenholme, B., deVos, V. and Malherbe, H.: toxoplasmosis in H"fyrge.e-6r7a:n8g5i1n.g8"5C5h,a1c9m7a3.baboons (Papio ursinus) from the Kruger National Park. TrR.aSocn .Trosp.M.ed. 22. deVos, V., van Kickert, C.A.W.). and McConnell, EE: A survey of selected bacteriological infections of the Chacma baboon (Papio ursinus) from the Kruger National Park. Koedog 16:1-10, 1973. 23. McConnell, EE.: Lesions found in animals exposed to coal tar acrosols. Proceedings of 4th Annual Conference on Environmental Toxicology. (AMRL-TR-73-125):189-198, 1973. 1f24r9.e7e4M-.crCaonngninegllb,abEoEo,nsBa(sPsaopni,oPu.rAs.i,nduesV)ofsr,oVm.,tMhyeeKrrs,ugBeJr.NaantdioKnuanltPza,rkR.E:OnAdsuervresy otfe1dipsVeoeatso.eRsreastm.o4n1g:,971-01068, 25. MacEwen, J.D., McConnell, EE. and Back, K.C.:_The effects of G-month chronic low level inhalation 20. Thigpen, JE, Faith, RE. McConnell, EE. and Moore, JA: Increased susceptibility to bacterial infection as a sequela of exposure 10 2,3,7.8-tetrachlorodibenzo-p-diosin. Infect.Immun. 12:1319-1324, 1975. 30. McConnell, EE. and Talley, FA: Intracytoplasmic hyaline globules in the adrenal medulla oflaboratory animals. Ver, Path. 14:435-440, 1977. 31. McConnell, EE: Parasitic discases observed in free-ranging and captive baboons.Comp.Path.Bull. 933.1977. i3n2.thMecsCuosnnmeolnl,keEyE.s,(MMoaocraec,aJm.uA.laatntda)Dafloglalrodw,inDgMa.s:inTgolxeiocriatlydoofse2.,3,T7,8o-textrAapicphlloc.rPohdoairbmelanzcoa.-lp.-d4i3o:x1i7n5(-1T8C7D,D) 1978. p3r3.elHiamsisn,arJ.yR.,reMpcoCrot.nn1e.lAlg,r.EEF.ooadnCdhHeamrv.an2,6D:J4:9,Ch1e9m7i8c.al and toxicologic evaluation ofFiremasterBBG: a d34i.beMnczCoopn-ndeilolx,iEnEs,inMomoircee,aJnAd,juHianseeampaing,s.JXT.oxainc.dAHpaprlri.sP,hMarWma.colT.he4c4o:3m3p5a-r3a5t6i,ve19t7o8xi.city ofchlorinated `3b5i.pMhecnCyolnn(ePClBl),tEoExi,ciHtaysisn JrRh.e,sAulstmmoann,keNyHs.(aMnadcaMcoaomruel,atJ.tAa.)::Atosxpicoonptaatnheooluogsy.ouLtabbr.eaAknoifmp.oSlcyic.hlorinated 29(5)666-673, 1979. b3i6.phAelntymla(nP,CBN)Ht.oxNiecwi,tiAynEr,heMscuCsonmnoenlkl,eyEsE.(MaancdacFearrmeulll,atTt.aL):: cAlinsipcoanltoabnscerovuastioountsb.rLeaabk.oAfnpioml.yScchil.orinated 205661665, 1979. `37m.etMhcyCloanznoexlylm,eEtEh.a,noWillascoent,aRt.e ainndthMeoFo3r4e4,TaJtA.:CDaonsceerreLseptotenrsse8o:f2711.-22-7d8i,m1e9t8h0y.lhydrazine and o3f8.2V.3a,n7,L8og-tteent,raMc.Jh.l,oGruopdtiab,enBz.o,diMocxCionnonenltlh,eEtEh.yamunsd.MoToorxei,coJl.Ao.g:yR1o5l:e13o5f-e1n4d4o,c1r9i8n0e.system in the action i3n9.thFeowrlaetr.,TBL..A,AnKiimnmteelgr,atC.eAd.,apWporoodasc,hJt.So.,tMhecCaosnsneeslslm,eEnEt.oafnldonGgr-atnetr,mLlDe.a:d tCohxricointiy.cTlooxwi-lceovle.lAlpepadl.toxicity Pharmacol. 56:59-77, 1980. 40. McConnell, EE, Moore, 1.A., Gupta, BN,, Rakes, A.J. Luster, ML, Goldstein, J.A., Haseman, J. and Parker, CE: The chronic toxicity oftechnical and analytical pentachlorophenolin cattle. 1 414,.2-Sdcimheethryi,hyCdMr,aCzairnlee.yC,aWnHc.eraLnedttMecrCson1n1e:l7l5,-7E9,E:19I80n.duction ofcolon tumors by a single oral dose of 4253..7Bi8r-ntbctaruamc,h1lDo.rodDiehceandz,ofGuMra,n iMnattthheemwosn,kHeBy.. aTnd MocCoxnAnpepilll.,PcEhaEr:omaFcalotle.o5f7:189-196, 1981. 46. Gupta, BN., McConnell, EE, Harris, MW. and Moore,J.A.: Polybrominated biphenyl toxicosis in the rat and mouse. ToxApiplc.Phoarmlaco.l. 57:99-118, 1981. 47. Lamb, ].C., Marks, TA, McConnell, EE. Abeywickrama, K. and Moore, J.A.: Toxicity of chlorinated `1p9h8e1n.oxy acids in combination with 2,3,7,8-TCDD in C57BL/6 male mice.1ETnoxv. ironHlt.h. 8:815-824, 4t8ox.iVciatny Loofg2t,e3n.,7BM-Jc.i,raGcuhpltoar,odBi.b,ienMzcoC-opn-nedlilo,xiEnE.(TaCnDdD)Moionrrea,tsJ..AT:osTihceoliongfylu2e1n:c7e7o-f88m,al1n9u8t1r.ition on the C31a9r.cDiunnongiecnke,siJsXb,ioParesjseaayn,ofJDal.l,ylHiassoetmhiaonc,yaJn.a,teT.hFoumnpds.Aopnp,lR..T.o,xiGciloels., 2:H1D1.4-a1n20d,M1c9C8o1n.nell, EE: g50o.ldMecnCohnanmesltle,rsE.E:NTNPTTPeTcehcnhinciaclaRlerpeoprotrtNoo.n2t4h9e,cNaIrHciPnuobgleinceastiisonbiNooa.s8s4a-y2o0f50a,mo1s9i8t3e.asbestosin syrian 5t1e.stKilnugsowef,pWhtMh.a,laMtceCoesntneerlsl,anFd.Er.elHautfefd, LcEo,mHpaoscumnadbn,ysJtKh.e, NDToPu.glaEsv,iJrFo.n.aHnedaMlotohrPee,rsJp..A:45C:a1r2c9i-n1o3g2e,ni1c9i8t2y. h52a.msFteelrdsma(nM,esDo.cB.r,icMecrCuosnnaeulrlat,uEsE).feadndvaKrnyaipnkgal,ev1e.l1s: oGfrporwottehikni.dLnaeby.dAinsicmaasleSacni.d3l2on(g6eYv6i1t3y-6of18s,yr1i9a8n2g.olden a53n.dDerxepwo,suRTr.e,dBuroaotrimoann,onG.cAa.n,cHeraisnedumcatinon,b.K,yMcaCkonnnoewlnl,caEEr.c,inBougseeny,inWr.atasn,dmiMcooeraen,dJ.hAa:mstTehres.effTeocxticoofla.ge `Appl.Pharmacol. 68:120-130, 1983. b5i4.phGeunpytlam,ixBNt.u,reMicnCotnhneelrlat, aEnEd, mGooulsde.sLteSiJinx,-mA.,oHnatrhries,xpMoWsu.rea.ndTMooore,xAJpApil:.PEchffaercomtsaoclf).a 6p8o:l1y-b1r8o,m1i9n8a3t.ed m5i5.xtGuurpetai,n BthNe,raMtcCaonndnemlolu,seE.E.,11M. oLoirfee,tiJmAe.satnuddy.HaTsoesmiaconl,. JAKp.:p.EfPfheacrtmsacoofla. p6o8l1y8b-r3o5m,in1a9t8e3d.biphenyl `5P6r.oMcecdCuornense.llT,oxEicEo:l. PPaatthhoollo.gy11r(e1q1u6i0r-6e4m,en1t9s83i.n rodent carcinogenesis studics. I Areviewofcurrent Ga1n.dSnoelolpevlealsdi,aHn.A.t,heHaFissecmhearn3,414X./aNnrdatM.cLCoNnantle,llC,aEnEce.rTIhnest.na7t2ur4a1l9h2i9s9to4r0y,of19b8o4d.yweight gain, survival s62t.ruMcctuKricn-nteoxyi,ci1.tDy.,reClhaatei,onKs.h,iMpcsCfoonrnpeollly,chLlEo.rainnadtBeidrbnibpahuemn,ylLsS.andStrreulcatteudrea-rionmdautctiicohnyvderroscuasrbons. Environ.HealthPersp. 1984. 6e3x.peSroillmeevnetladl, HonAc.ogaenndesMicsC.oTnonxeilclo,l.EPEa:thoTlh.e7s2i:g0n2i9fi-c9a4n0c,e1o9f8i4n.terim sacrifice and lifespan data in 4Di.oxMicnCoinnnseolill:,BEiEoa,vaLiulcaibeirl,itGy:Wa.f,teRruimnbgeasutgiho,n bR.yC.r,atAslbarnod, gPu.Wi.n,eaHaprivgas.n,SDc.iJe,nHceas2s2,3J:1.07a7n-d10H7a9r,ris1,08M4W..: a65d.miDnuinsntiecrke,dJoXr.a,lD8a-vmiest,hWo.xEy.p,sJoorragleenns.onNa,tl,T.A.C,anRcoseern,InstV..J.MoannodgMrc.Co66n:n9e1l-l9,5,EE1:984S.ubchronic toxicityinrats T66w.o-HyaesacrmCaanr,ciJnKo.g,eCnriaciwtfyorSdt,udDi.eDs.,CHounfdfu,cJtEe,dBaototrhmeaNna,tiG.oAn.a,laTnodxiMccoCloongnyePlrlo,gErEam:.1R,esTuolxt.sEnfvriormon8,6Health 14621639, 1984. 6H7i.stHoupfaft,hJoEl,ogByatRees-,cRx.a,mEiunsattiis,on5.ofHtahse aNant,io1n.aDl.,CaanndceMrcCInosntnietultle,'sECEa.rcMianloagtehnieosnisaSntdudMiacls.aoExnovni:ron. Res. 37154173, 1985. 6E8n.viMrcoCno,nHneealllt,hEPEe:rspC.om6p0a:2r9a:t3i3v,e1T9o8xi5city ofPCB's and Related CompoundsinVarious Species of Animals. 6R9e.suHlutlsf,in10C.a,rcMicnCoognenneilcilt,yESEt.udaineds iHnaAsneimmaanl,s.JKE.n:viLretotnemrentotatlheMuEtdaitgoerneosnitshe7:P4r2o7p-o4r2t8i,on19o8f5.Positive T70e.rmSiolnlaetvieoldn,DHa.tAa.,inaLndonMgcCtoenrnmelTlo,xiEcEi.:ty Tanhde VCaarlcuienaognednSeisginsifSitcuadnicees.oTfoLxif.ePaStpha.n1a3n:d12S8c-h1e3d4u,le19d85. O71b.seHravseedmainn,UnJtXr.e,aHtuefdf,anJdE,CoRaron,OGiNl.G,avAamgoeldC,onJtEr.olBGoroormuapns,ofG.FA.3,44a/nNd RMactCsonannedllB,GECE3:FLNMeiocpe,l1aNsamtsl, CancerInstitute 75(5:975-954, 1985. S7t2u.dMiecsC)o.nnNeTllP,TEecEh:niTcoaxliRceoploorgty Naon.d2C0a5r,ci1n9o8g5e.nesis Studics ofChrysotile Asbestoisn F344/N Rats (Feed G76A..McRCiocnhnteerl,l,C.EET,heBuTcohxeirc,itIyR.o,fSMcehtwheytlz,IsBo.cAy.,anGautpet.a,EnvBiro.n., ShSeclibey,ncMe.TDe.c,hLnuoslte,r,21M:.1,8B8r-o1d9y3,,A1R9.8,6.Boorman, F7i7s.chMecrCo3n4n4e/lNl,raEtEs:anNdTBPGTCe3cFh1nimcialcere(pgoarvtagoenstthuedyc)a.rcNiTnoPgTeencehsniiscbailoRaesspaoyrtofNod.ig2l5y7c,id1y9l8r6e.sorcinol etherin T78o.xiBcuicthyeorf,MJeR.t,hSyclhIwsoectyzanBa.tAe.CSohneflebrye,nMc.eD..EnMvciCroonnn,eHlela,lEthEP:erIsnpt.ro7d2u:c3t,i1o9n8t7o.the Proceedings of the `7E9n.vMicrCoonnmneenltla,l aEnEd,Rcetlaalt.e(dPrPerpoagrreadmsb,ySauWbocrokmimnigttGereouopnfRoirskthAessDeHsHsmSeCnto)m:miRtetpeoerttoonCoCoarndcienratReisks `Associated with theIngestion ofAsbestos.Environ,HealthPersp. 72:253-265, 1987. 80. McConnell, EE: Letter to the Editor on Cancer Phobia. Science 238:50-60, 1987. C81a.rcHianosgcemnainci,tJyX.S,tHuduifesf.,EnJEv,irZeoing.erH,eaE.l,tMhcPCeornsnpe.ll7,4:E2E2:0-2C3o5m,pa1r9a87t.ive Results of 327 Chemical W8.2,. HHaurftf,,1J.EG.,,MRcalClo,nDn.ePl.l:,CEaEr,ciHnoagseenmeasni,sJSKt.u,diBcos:orRmeasnul,tsG.oA.f,3E0us8tiesx,peSrLi.meSncthsweotnz,10B.4A.c,hReamoi,caGlNs,frJoammetshoen, US. NationalToxicology Program. inLCivihngienamicaWorlld, AnN.Y.Aacad.lSci.5341-30, 1988. 8c3a.rcHioneolg,enDi.cGi.t,yHsatsuedmieasn:,i1mpKl,icHaotgiaonns, fMo.rD.r,isHkufafs,seJ.s,sMmceCnotn.neClalr,ciEnEo:genTehseisim9p:a2c0t45o-f2t0o5x2i,ci1t9y8o8n. 8344.4M/cNCorantnsel(lf,eedEEs:tudyN)T.P NTeTcPhnTieccahlnirceaplorRtepoonrtthNeo.car3c3i5n,og1e9n8e8s.is bioassayofcrocidolite asbestos inFischer 815.3.BMuetlanidcike,neRLb.y tHuhfefN,a1tEio.naHlasTeoxmiacno,loJ.gKy..PMrcoCgornanme.lAln,nE,EN:.YC.hrAocnaidc.Stcoixiecnicteysre5s3u4l:t6s4a8-n6d6o2n,g1o9i8n8g.studiesof 86. McConnell, EE The masimum tolerated dose: The debate.1,Am,Coll.Toxicol. 6:1115-1120, 1989. 8ra7t.sM(cfCeoendnsetluld,y)E.E:NTNPTTPecThencihcnailcaRleproerptorNtoo.n27t7h.e cMaarrccihno1g9e9n0e.sisbioassay oftremolite in Fischer 344/N F88i.scMhuerrtFh3y4,4A/SnXi.n,rMatcsCoannndelBlG,CEIEF.I, Hmuifcfe,eJxE.poRsuesdsftioelddi,glAycBi.dyalnrdesGoorocdi,noAlEe:theFro-rAesnteopmoaxcyhnrecsoipn.laFsoomds.in Chem,Toxic, 28723729, 199. s93t.udMiceCsoonfnetlwlo,gErEa,deHsuofffp,enJEt,aHcehfliomraonpchiekn,olM.i,nPBetGeCr3sF,LA.mCi.cea.ndFuPnedrs.iAnpgp,lR..ToTxoixcioclo,lo1g7y:5a1n9d-5c3a2r,ci1n9o9g1e.nesis 9H4a.lpIebrrianh,iWm,EM,AM.cCoBnonnedl,lG,.EG,E.BuMrukner,oT,.A1,.,C.,CoSlwee,n2b.erDgo,stJ,AF,.\.Z,ahEnmt,erSlHin.e,anP.dE.GrGaohuagmh,,1M:.WGeriegehntbeorfg,thReS., evidence on the human carcinogenicity of 2,4-D.Environ,HealthPersp, 96:213-222, 1991. 9s5t.udMiceCsocnonenldlu,ctEeEd:bTyhtyhreoiNdCIf/oNllTiPc.ulRaergc.olTlocxairccoilno,gPehneismis,: 1R6es:u1l7t-s18f8r,om1939423.two-yearcarcinogenicity i96n.haHleesdteprobleyrpgr,opTy.Wl.e.neMcbCeornnselinl,raEtEs.,.FuMinldle.rA,pWp.lC..,ToHxaimciollt,on1,9R:.35a8n-d36B6u,n1n9,9W2..B. Pulmonary toxicity of 97. Hesterberg, TW. Miller, W.C., McConnell, LE, Chevalier, J, Hadley, J. Bernstein, DM, Thevenaz, P. `aTnodxiAcnold,er2s0o:n46,4R-.47C6h,ro1n9i9c3.inhalation toxicity of size-separated glass fibers in Fischer 344 rats. Fund.Appl. 9c8x.peMrciCmoennntealll,anEiEm.alasn.dInSwBeuntbaedrige,ne1.a4.ndStSytryerneenca:nAdsssteysrsemneenotxiodfe:HeRaelstuhltHsazoafrsdtsu,diJeAsRoCnScciaernctiinfoigcenicity in Publications, Vol. 127: 323-333, 1993. 9Pa9t.hMolcoCgoyn,ne2l2l:,14E1E.1a44n,d 1F9u9s4t.is, S.A. Peerreview incarcinogenicitybioassays -Uses/abuses. Toxicologic r1e0l0a.teLduc1a0saLgueijineklxo,nNgB-t,erRmaot,oxGicNi.t,y MsctCuodniense-llC,onEsEi,deWruarttizoenns,fGo.r rainsdk Karsoseess,smRenTth.eRiengt,aTkoexoifcaclh,ePmhiacramloscal., 20:96-104, 1994. T1h01e.veMncaCzo,nnPe.lClh,roEnEi.cKianmhsatlrautipo,nOs.,tuMduyssofelsmiazen-,scRp.,arHaetsetderrboecrkg,anTdW.s,laCghwevoaollieirn,suJl.aMtiilolnerf,ibWe.rCs.inanFidscher 344/N rats.InhalationTosicol., 6571-614, 1994. R1e02l.atHieosntsehribpebreg,twTeWen.hMuinilglebri,osWp.erC.s,isMtaesntc,eR.a,nMdcbCioonlnoeglicla,lEeEf,fecBtesrnosftemiann,-DmMa.deanvditArnedouesrsfoibne,rsR.after chronic inhalationin rats. Environ, Hlth. Persp, 102:133-137, 1994. 510334..1M9c9C4o.nnell, EE. Syntheticvitreous fibers - Inhalation studies.Reg.Toxicol,Pharmocol, 20 (2)522- L10R7.. MMialslte,r,RWW..C.McaCnodnnHeelstle,rbEeEr,g,ATndWe.rsSotnu,diRe.s, Cohnatvhaelicehrr,o1.nKiocttionx,icPi.t,yB(eirnnhsatleaitni,onD)Mo.f,fTohuervteynpaezs,oPf., Glass, refractory ceramic fiber inmale Fischer 344 rats.InhalationToxicol. 7:425-467, 1995. G1l0a8s.s,MaLsRt,,RMiWl,erM,cCWo.nnaenldl,AnEdEe.r,sHoens,teRr.bAermgu,lTt.iWp.l,eCdhoesvealciherr,onJi,cKionthianl,aPt.i,oTnhteovxeinciatxy,sPt.,udByeronfstseiizne,-DseMp.a,rated Kaolin refractory ceramic fiber (RCF) in male Fischer 344 rats.InhalationToxicol. 7:469-502, 1995. 110999.5.McConnell, EE. Advantages and limitations ofin vivo screening tests.Ann.Occup.Hyg, 39:727-735, q1u1a0r.tMzc.COocncnuepl.l,EnEvEi.roFni.bMroegde,nic52e:f6fe2c1t-o6f24w,ol1l9a9s5t.onite compared with asbestos dust and dusts containing o1f11v.ieMwc.CIonnhnaellalt,ioEnET.oxTihceolm.ax8i(mSuupmplt)o:l1e1r1a-t1e2d3,do1s9e96i.n particulate inhalationstudies: Apathologist's point K1a12m.stMrcuCpo,nnOe.l,la,nEdEH,adHleesyt.erJ.beRregs,ulTt.sW.o,fClhiefvea-ltiiemre,iJn,haTlhaetivoennaszt,udPi.,esKootfing,laPs.s,,Mmaisnte,rRa.l, aMnudsssellamgawno,olR.s, and r1e9f9r6a.ctoryceramic fibersin rodents. I. Occupat.HealthSafety:Australiaand NewZealand, 12:327-332, O1b1e3r.dHoersstteerrb,erGg.,UTs.eW.o,f MlucnCgo,ntnoexlilc,itEyLaE,ndMiJlulnegr,pWa.rCt.i,c,leChcelveaalriearn,ce1.toEveesrtititm,a.t,e Tthheevmeanaxzi,mPu.,mFlteoilsesrnaetre,dHd.oasend (MTD) for a fiber glass chronic inhalation studyin the rat.Fund.Appl.Toxicol,32:31-44, 1996. 1C1h4a.seH,esGt.Re.r,bearngd,TTh.eW.v,enAaxzt,enP,. CC.h,rMocnCiocnnienhlall,atEiEo,n sOtbuedrdyoorfstfeirb,erGg.l,asEvsearintdt,aJm.oMsiiltleera,sWb.e,sChteoivnsalitehre,SJy.riJa.n `gmoalddeenFihbarmosutsera:ndTwNeolnv-efimbornotushpparretliiclmeisn,arLyakreesPullatcsi.d,SiNx.tYh.I1n5t-er1n9aStieopntal19C9o6n.fEenrveinrcoen.oHneNaalttuhrPaelrasn.d Man105:1223-12290, 1997. M1J1.5,. MToafyte,s1,DB.AS,inMgceCro,nAneWl.l,BErEow.nN,eaIlF,.BJrH.,,MeBnrtunonne,rR,.B1..)anHdamMiolotroen,,JS..A3..,CSoumlplaivraant,iTv.eM,CaPrerctienrosg,enA.iCc.i,tyRyiann, Sprague-Dawley Rats of the Polychlorinated Biphenyl Mixtures Aroclors 1016, 1242, 1254 and 1260. Toxicol.Sci, 41:62-76, 1998. O1b1e6r.dHoersstteerrb,erG.g,UTs:eW.,ofMlcuCnognntoexlilc,itEyEa,ndMilllnegr,paWr.tCi.c,leChcelveaalriaern,ce1,foEveesrtititm,atJ.e, Tthheevmeanaxzi,mPu.mFtloeliesrsanteedrH,d.oasend (MTD) fora fiber glass chronic inhalation study in the rat. Fund. Appl. Toxicol. 32:31-44, 1996. 31109.viMrcusCoinnnSeylrli,anEEg.oladnednChaarmbsotneer,s.MI.nhAalcaotmipoanrTiosxiocnoolf, p1l2e:u1r7al3-m1e8s1o,t2h0e0l0i.omas inducedbyasbestos and SVTo1x20i.coMlc.CoPnhnaerlmla,coElE,.3A2:sc14i-e2n1c,e-2b0a0s0e.d paradigm for the classificationofsyntheticvitreous fibers. Regt c1a2r1c.iMnaosgetn,iRciWty.oYfur,egC.rPa,c,tOobreyrcdeorrsatmeirc,AGb.e,rMicnCotnwnoelclh,roEnEi.c FainsdchUetrel3l,:4MJr.atAinrheatlraotsipoenctsitvuedircesv:ieAwnof the assessmentof the MTD and implications for risk assessment.InhalationToxicol.12:1141-1172, 2000. C1h22r.onFirceeNmeaurno,toG.xBi.c,iStiyngoefrA,rAocAl.orLMoirxdtou,reRs.AA.dPmeitneirss,teAr.eC.d,iNneaDli,etB.fHo.,SpMrcaCognunee-lDla,wlEeEy,Raatnsd.FMuanydes.,ApBpAl.. Toxicol. 53:377-391, 2000. i1n2h3a.laKtaimosntrstuupd,ie0s,oEfllfeonhatnyupgee,s Ao.f, sCthoevnaelwieoro,lJf,ibDearvsisi,n JraMtsG..inMhcaCloantnieonllT,oxEicEola.nd13T:h6e0v3e-n6a2z2,, P2.0C0h1r.onic v1i2t4.reMoausxifmib,erLs:D.AawnedigMhctC-oofn-ntehlel-,cvEiEd.enIcnetearpsppreocaicehs.cRoempga.Troixsiocnoslo.fPhtahremtaocxaicli.ty33o:f1-a2s4b,es2t0o0s1.and synthetic 112558.1,M2c0C0o1n.nell, EE. The value ofhuman testing ofpesticides. HEumcanoandlogiRisckAsasesls. 7:1575`1m26e,thModc.CoInnhnaellalf,iEoEnT.oaxnidcoJlM..G1.4:D1a0v1i-s1.10Q,ua2n0t0i2f.ication of ibrosts in the lungs ofrats using a morphometric PParperpsairnation/Submitted/Accepted/In Press: `GWreaiyg,htGMof,thCeoheevni;deJn.cTe, Cevuanlhuaa,tiGo.n, Hofuglhoews-,doCs.,eMrceCpornondeulclt,ivEeE.a,nRdhdoemvbeelro,pmLe.,ntSaiplese,ffLeGc.tsanofdBMiastpthiesnoonl,AD.. `Book Chapters,PublishedSymposia,Reviews: 119M5c6C-o1n9n6e5ll(,ThEeEsi:s-A1s0t6u5d)y of 76 canine hemangiosarcomas recordedat Michigan State University from 2. McConnell, EE: Yaba virus tumors. National Cancer Institute Monograph 32:239-224, 1969. 3. Diamond, $5. and McConnell, EE. Veterinary pathology in toxicology research. AFMed.Sve.Dig. d7.ibMeonozroef,urJa.An.s,.McACnonn,neNlvl,AcEaEd..SDcail.ga3r2d0,:1D5.1W-.16a3n,d1H9a7r9r.is, M.W.: Comparative toxicity of halogenated 8`.muMtcaCgoennneesilsl., EInE::R.AcKuitmebraonudgchhr(oendi)cHtaolxoicgietny,atceardcBiinpohgeennyelssis,,Terrepphreonduycltsi,oNna,phttehraalteongeesne,siDsibaenndzodioxins andRelatedCompounds. Elsevier North Holland, pp. 109-150, 1980. 9F.reiM,cEK.iMnenreiaynJ,,. .anPdoMcecbCioanrniel(le,ds.E)E.C: SthructluraDloisopxecirinfsiaciintydRanenldattaheeddCtioomxipenoruendcedpsto-rI.mIpna:ct0.onHutthzeinger, RW. Environment. Pergamon Press, New York, pp. 367-381, 1982. 10. Huff, J.E., Haseman, J.K., McConnell, EE. and Moore, JA: The National Toxicology Program, toxicology SadEfaotarvyevalauatilon tuoecfhDnariquugetssaanndidCthheoemilcoannlgs-.terTmowcaarSctiantoegeUnnievseirssibtiyo,asAsiays.,PJA,rJuoe c19o8e1f.tehedSymiponsiugmosn 11. McConnell, EE., Wagner, J.C., Skidmore, JW. and Moore, J.A:: A comparative study of the fibrogenic BainoldocgiacracliEnfofgeencitcsoefffeMcatns-omfaUdIeCMCiCnearnaaldiFaibnrecsh.rysWootrilled BHeaaslbtehstOorsgaannidzagtliaosns,m1i9c8r4o,fipbpr.e2J3M4-215002).. In: P1r2o.ceMecdCoinnngeslolf, CECEE:RPCoCmopnafrearteinvceeotonxiPcoitteynotfiaPlCHBesalatnhdEfrfaetcetsdocfoPmCpRosuannddsRienlavtaerdioPuesrssipsetceinetsHoafloangiemnaaltse.d Hydrocarbons. National Institute of Environmental Health Sciences and Finland. 1984. 225.230, 1985 13. McConnell, EE: The clinicopathologic changes in various species of animals caused by dibenzo-p-dioxin. In: M. Kamrin (ed.) Diion thxeEnivironnmesnt. Hemisphere Publishing Corp., pp. Bi14o.loMMgciCcoeanlnecll,hEE:aCnloinfiiDcioopsaxtihnoAmlcotgiisconC.onpcpep2t7s-o37f,D1i9b8e4n.zo-p-dioxin Intoxication. In: BanburyReport18: C15a.rcMicnCoognenneelsli,s ETEes:tiInsgsuaensdREaviasleuadtbioyn.theInN:aPtrioocnaeledTionxgiscoolfo1g5ytPhrCoognrfaemrAedncHeoocn PEannveilroonnmCehnetmailcTaolxicology October30,31,andNovemL,b19e8r4. Universitofy California, Irvine, Wright-Patterson Air Force Base, Ohio, AFAMRL-TR-84-002, pp 136-143, 1985. 16. Boorman, G.A., Montgomery, C.A., Jr., Eustis, S.L, Wolfe, M.J., McConnell, E.E., and Hardisty, J.F.: Quality assurance in pathology for rodent carcinogenicity studies. In: Hanofd Carcbinoo genToestking (HA. Milman and EX. Weisburger, eds.), pp. 345-357, 1985. Q1u7a.liMtcyCoonfnTeolxli,cEolEo:gyQSutauldiitcysa.ndPrtihneceNtaotnioSncaelnTiofxiiccPoulbolgiysPhrinoggrCaom.,.InInc:.Mpapna9-g1i2n,g1C9o86n.ductand Data M2c0.CoLnenmeelnl,, ER.E,,BeMcekiinnhga,rGd.sC,:,T.C,aMntiolrl,eiKt,e,]ChRe.,rnPeatre,l,JHY.,, SCoonridclhe-,mFu.l,lGirno,tCh.,aD.n,dKTeolllelre,fsCo.,n,LyL.baRregpeorr,tJ.on Cancer Risks Associated with the ingestion ofAsbestos.Environ.HealthPersp,72:253-265, 1987. C21W..,HuHfafr,iJ,EL.G.M,cCaonndneRlalll,, EDE.F..:HaCasrecmianno,geJnXe.s,isBoSotrumdaicns,RGe.sA.u,ltEsusotfis3,98SLE.xpSecrhiwmeetnzt,sBo.An.,1R0a4o,ChGe.mNi.,caJlasmefsroonm, the 11.5. National Toxicology Program.ProceedingsoftheCollegiumRamazziniConferenceon "Living ina ChemicalWorld," N.Y. Acad. Sci, 534: 1-30, 1988. 22. McConnell, EE: Mouse `SpeciesComparisons, Alan liver tumors; the R. Liss, Inc. New Yporrokb,leNmY., 1I-n:3,Mo19u9s0e. Liver Carcinogenesis: Mechanisms and 23. Elwell, MR. and McConnl, EE: Small and large intestine. In: PathoftohelFisochegrRayt,Academic Press, New York, NY, 1990. m24a.nH-emsatderebefirbge,rTcWa.rc,inVoug,enV.e,siMsc.CoInn:nCeellll,ulEaEr,anBdunMno,leWcBu.laarnAdsApnedcetrssoofnF,iRb.e:rUCsaercoifnoagneinmeaslimso,deedls.sBt.o study BrinkleyJ. Lechner and C. Harris. Banbury Report, 183-205, 1990. C25h.roHneiscteirnbharlga,tiToWn.t,oxMiacsitty, Ro.f,rMecfCroanctnoerlyl,ceErEa.miCchefviableiresri,hJS,yBreirannshtaeimns,teDr.sM..,PBurmo, Wc.Be.oaefnIddnAtneirdnenartsigoonn,salR. WorkshoponMechanismsofFibreCarcinogenesis, Albuquerque, NM, Oct. 1990. T26o.xiAcnoilomgayl,sNaastiSoennatlinReelsseoafrEcnhvCioruonncmieln,tNaoltiHoenaallthAcHaazdaermdys.PrBeosasr,d19o9n1E.nvironmental Studies and 2a7n.dBTelaly,loRrH,,K.FCe.iRgleevyi,eC.Eo.,f tGahuel1d1eSn,,AMmEy, HEanlvpierroinnm,eWn.t,aHlarHryigsi,eEn.e, KAigmemnecly,TCo.xAi,coKloodgeyllD,ivRiLs.ioMnc,CCoonmnmeillt,teEeE. on Toxicology, National Research Council, National Academy Press, 1991. 2P8r.ovGiodveeUrnncmeerntatinAcPcrooutencttiinogn.OfGfAiOce/.PREeMpDr-o9d2u-c3t,ivWeasahnidnDgetovne,loDp.mCe.nOtcatlobTeorx,ic1a9n9ts1:.Regulatory Actions 29. McConnell, EE. Comparative responses in carcinogenesis bioassays as a function ofage at first Eedxsp.osPu.rSe..GuIzne:lSiiamni,laCr.iJt.iHesenarnyd and S.5. OliDifernncs,BeItLSw]eePnreCshs,il19d9r2.eanndAdults:Implifocr RaistkAsiseossmnenst. f3u0.ncMtciCoonnnofelalg,eEaEt.fiErfshtyelxepnocstuhrieo.urIen:aS(iEmTiUl)a:riCtoimespaarnadtiDvieffreesrpeonncseesinBertowedenenCt charicinlaogndednAerdsuiesltsnst:udies as a `Implications for Risk Assessment. Eds. P.S. Guzelian, C.J. Henry and S.. Olin, ILSI Press, 1992. 3R4W..,McMCclCelolnanne,llR,O.E,E.Miallnedr,RFe.iJn.,haHredstt,erCb.eFr.gA,pTp.rWo.,acWhaershetiot,EvDa.lBu,atBiunngn,thWe.BT.o,xiKceintey,aAnBd,CaLricpipnomgaennni,ciMt.y, Mofast, To`xMiacno`lNa,dPehFairbmer,s:16S:u3m21m-a3r6y4,o1fa99W2.orkshopHeld November 11-13, 1991, Durham, North Carolina.Reg. 3C5h.emSeilceaclteSdafeStyyn,thWeotrilcdOrHgeaanlitch OFirbgraensi.zEatnivoinr,on1m9e9n3t.al Health Criteria#151, International Programme on e36f,feMcctsCoonfnechlrly,soEtEi,leCahnevdalcireorc,idHolLi,teHaessbteesrbteorsig, Tr:aWt.s,aHfatdelrefya,ha1lGa.tiaonndeMxapsots,urReW.forC2o4mpmaornitshosn.Ionf:Tthaesicand CarcinogenicEffectsof Solid Particles in the Respiratory Tract, ILS] Press, Washington, DC. 1994. 3E7f.feWctasgnoefr,InBgMes.t,edBuFrltu,orB.iAd.e,,CCaonmtmori,ttK.ePe,oKnreTwosxkiic,olDo.g,yL,eNvayt,iSoMn.a,l MRceCsoenanreclhlC,oEunEc.ila,nNdaWtihointaflorAdc,aGd.eM.myHealth Press, 1993. I3n8h.aHleasttieornbTeorxgi,ciMitiylloefr,MaW.nC-.m,aMdceCoVninterlelo,usEEFi,beBresr:nsRteeliant,ioDnMsh,ipThtoevLeunnagz,BuP.rdaenndaAnnddeLrusnogn,ReRt.enCthiorno.nicIn: To1x0i9c.andCarcinogenicEffectsofSolidParticlesintheRespiratoryTract, ILSI Press, Washington, DC. 39. McConnell, EE, Greaves, , Kimmel, CA. Kodell, RL, KollerL Medinsky, M. and WolvenGarret, A. HPNeaatlietohnEarlffRemecsteseoarfcth Chounrcil,iNantio-nalIAcmadepAmrymrPyrBeeastst,gl1e9-9nD4r.eassUtnifeordms.Committee on Toxicology, 4Cr0i.t.MRceCvon.Tnoelxli,coElE,.2a4n:d54S9w-e55n5b,er1g9,9J4.A. Review ofStyrenc and Styrene Oxide : Long-termAnimal Studies. e41x.peMrctCsoantntehelhleEaEr.i,nRgesopnomnsaen-tmoatdheesmeisnaernadlqfuiebsrtesi,onBsersluinbm9i/t1t0edDebcyeFmebdeerra1l9H9e3a.ltEhxcOefrfpitceinto the invited MKedirzene-Vebrl,sMugdcuhreenc,hfGkuenrasmtalnihyc.herMinderaulfanscegm, (Ed. M. Fisher), pp.63-65, Bga-Schriften 94,4, MMV, 4F2o.wlFeirn,n,B.W, EGo,itHsecmhasltkr,eeCt.WI.I,,MGcPCo,nAnlelleln,, EB.EC..,NAonbdleer,sBo.,n,PaRr.kLe,r,BeJr.Cn.dta,nWd.P0o.r,tEerp,stGe.iAn.,BEiHol,ogFiocuMlakersk,erEsCi,n UrinaryToxicology, Board on Environmental Studies ind Toxicology, National Research Council, National `Academy Press, 1995. O4b3.erNdRoCr.stLeir,ppGm.,anRnh,omMb,erCgh,ia1zRz.e,e,UtLe.,ll,CoMu.l,taasn,dDW.aBr.,heDirti,scDo.l5l,.RKeEp.orKtaonne,tAheBE.xpLoecrktePya,n1eEl,onMcHCeoanlntehllE,ffEecEt,s c1.hlVoarnodStiefel,uoErWo.m,cMthcaCnocnn(Fl-l22,).EEP,roPcaeteeld,i1nAg.s FainrdstHIanmtleimna,tiRo.nLa:lTChoengirnehsalsaotnioTnotxoixciocliotgyyo.ftAhceadreefmriigcerParnets,s, NewYork, p. 602, 1978. 2a.ssKeismsmmeeln,tCoAf,chGrroannitc,lLeDad,tFoxoiwclietry., BP.rAo,ccMecdCiongnsneFlirlstEEIn.tearnndatWiooondals,CoJn.gS.r:esAsnoinntTeogxriactoeldogayp.prAocaacdhetmoitche Press, New York, p. 573, 1978. `3m.iMcec,Cognunienlela,pEigEs..aTndoMooxreA,ippJlAc.:PhoTarhmelaccoo.mlp.a3r7a:t1i4v6e,t1o9xi7c6i.ty ofchlorinated dibenzo-p-dioxinisomersin d4.ibMceCnoznon-epl-ld,iEoEx,inMomoircee,aJnAd.jHuairnreias,piMgWs.anadndrhHeassusemmaonn,keJ.yDs.:.ETnhveirtoonx,iHceitaylotfhcPhelrosrpi.na2t0e:d245, 1977. (5.TTChDiDg)peonn,hJoEs.t MrcesCiosntnaenlcle,tEoEi,nfMecotoiorues,agJAe.natsn.dEFnavitihr,oRn,EH:eaElftfhePcetrsospf.2,230,:72.485-,te1t9r7a7c.hlorodibenzo-p-dioxin 6h.alMocgCeonnanteeldl,diEoEx.inasn,dfuMrcaKnsi,nnbiepyh.e.ny.lsExaqnudisniatpehtfhoaxliecnicsti.ny tTheoguixneAapipplicg.Pthooasrtmlraucco.tlur.a4ll5y:s2i8m,il1a9r78. 7c.oMmomoerrec,iaJ.lA.,polLuysbtreorm,iMnaLt,eGdubpitpah,eBnyNl.mainxtduMrceC.onTnelol,xEEA.ip:plTc.oPxhioacorlmloagcio.cla.l a45n:d17i6m,mu1n9o7l8o.gical effects ofa M8ecMtciCnognnoefllt,heEIE.ntaernadgeMnocoyreC,olJlAab:orTatoixviecoGpraotuhpoloongyEncvhairraocntmeerinsttailcsCaorfctihneohgaelneosgiesn.atNeadtiaornoamlatCiacnsc.er45th Institute, May 23, 1979, Bethesda, MD, c9.omBpoaorramtainv,e Gc.iAf.c,ctMscCofonannealnliEmEa,lsCaogcekraetlltiBm.eYo.,fDerxepwo,sRu.rTe,aSntdoneex,pCo.sJ.u,rHeadsuermaatni,onJXo.n and Moore, JA: vinyl chloride The c1a9r8c0i.nogenesis. Federation ofAmerican Societies forExperimental Biology, Anaheim, CA, April 13-18, I1m0.paMcctKionfnCehyl,orJ.iDn.ataenddDMicoCxoinnnselaln,d EREel:atSetdruCcotumrpaol usnpedcsifoicnittyheanEdnvtihreodnimoexnitn,rReocempet,orI.talWyo, rOkctsohboepro2n2:24, 1980. (11T. CMDcDC)otnonxeilcilt,y-ETEi.piadnadssSihmoialta,tiCo-nR..1.(1M9o8r1p)hoSltougdyi.esPohfartmhaecmoleocghiasnti,s2m3:o1f762.,3,7.8-tetrachlorodibenzo-p-diosin 12. McConnell, EE: Histopathologyworkload in carcinogenesis bioassays. Howmuch is necessary? The 16. Solleveld, H.A. and McConnell, EE: Time-age associations in experimentaloncogenesis. Third International Symposium of the Society ofToxicologic Pathologists, Arlington, VA, 1984. 17. McConnell, EE: Quality and the National ToxicologyProgram. NTP- IndustryJoint Conference on Managing Conduct and Data Quality ofToxicologyStudics, Raleigh NC, 1985. 18. McConnell, EE: Guidelines for CombiningNeoplasms for Evaluation ofRodent Carcinogenesis Studies. International Life Sciences Institute Histopathology Seminar,Hanover, Germany, 1985. 19. AdkinsJr. B., McConnell, EE: Inhalation Carcinogenesis Study ofWollastoinRiattse. Second US.-Dutch International Symposium: Aerosols, Williamsburg, Virginia, 1985. 20. McConnell, EE. Options for Aggregation of Incidence Data. InterdisciplinaryDiscussion Group on Carcinogenicity Studies, Chapel Hill, Noxth Carolina, 1986. 21. McConnell, EE: Fiber Toxicity: Beyond the Stanton Hypothesis. American Society ofMining Engineers, Phoenix, Arizona, 1988. 22. McConnell, EE., Hejtmancik, M. Peters, A.C., Persing, R. Chronic ToxicityofPentachlorophenol. Ann. Meet., Soc. Toxicol, Atlanta, GA., 1989. T2o3.xiAcdokli,nAst,laB.n,taM,cCGoAn.ne1l9l8,9E.E. Hall, L. CarcinogenicityStudies ofWollastonite in Rats. Ann. Meet., Soc. 24. McConnell, EE, Haseman, J.A. and Boorman, G.A. Proliferative Lesions of theThyroid Gland: A Review ofthe National Toxicology Program Data Base. Ann. Meet., Soc. Toxicol. Main, FL., 1990. 25. McConnell, EE. Comparative Responses in CarcinogenicBioassays as a Function ofAge at First IELxSpIo/sRuSr1,e.HuinntSiVmailllaeryi,tiMcsD,anNdovDeifmfbeerre,nc1e9s9B0e.tween Children and Adults: Implications for Risk Assessment, 26. Hesterberg, T.W., Mast, R., McConnell, EE, Vogel, O., Chevalier, J., Bernstein, DM. and Anderson, R. Chronic Inhalation Toxicity and Oncogenicity Study ofRefractory Ceramic Fibers (RCF) in Fischer 344 Rats. Ann. Meet., Soc. Toxicol, Dallas, TX, 1991 alsoThe Toxicologis L185 (254), 1990. E27f.feMcctsCoonfnCehlrly,soEtEi,leHeasntderCbreocrigd,oTliWt,e AHsabdelsetyo,sJ.iG.n,RaBtesrnAsftteienr,IDnhMa.latainodnMfaosrt1,0RMWo.nthAsC.oAmnpna.rMieseotn,oSfotch.e Toxicol, Seattle, WA, 1992, alsoThoexicologist 12:90 (274), 1992. 28. Glass, LR., Mast, RW., Hesterbery, T.W., Anderson, R. and McConnell, EE. Inhalation Oncogenicity Study of Refractory Ceramic Fiber (RCF) in Rats - Final Results. Ann. Meet,, Soc.Toxicol., Seattle,WA, EGfefremcatsnyo,fS3olMiadrPcahrt1i9c9le3s.in the RespiratoryTract. th International InhalationSymposium, Hannover, `3A1n.dHeersstoenr,beR.rgC,hTr.oWn.i,cMiIlnlhearl,atWi.Co.n, ToMxciCcointnyeolfl,FiEb.rEo,uHsaGdllaeys,s 1inGR,atBse.rinsntTeoinx,icDolMo,giTchaenvdenCaazr,ciPr.ioagnednic Effects oMfarScolhid19P9ar3t.icles in the Respiratory Tract. 4th International Inhalation Symposium, Hannover, Germany, 3 I3n2t.rMaatsratc,hRcaWl.anGdlaBsiso,pLerRs.isMtceCnocnenSetluld,ieLsE,ofHReesftrearcbteorrgy,CTeWra,inaincdFiAbnedrse.risnonT,oxRi.coClhorgoinciacnIdnhCaalractiionno,enic EGfefremcatsnyo,fS3oMliadrPcahrt1i9c9l3e.s in the RespiratoryTract. 4th International Inhalation Symposium, Hannover, t3o3x.iMciatsyt,StRuWd.y,oMfcKCaoonlnienllR,efErEac,toGrlaysCs,erLaRn.icanFdibHeers(tReCrPb)erign,MTaWle.FiAscMhuelrti3p4l4e DRaotsse.TChhoersoincicolInohgailasttio1n3:43 (63), 1993. C3h4r.yMscoCtoinlneealnld, CErEo,ciHdeosltieterbAesrbge,sTt-o.s,inHaRdaltesy,afJt.eGr.,IanbnadlaMtaisotn,-R2W4.MoAntCohmRpeasrulitsso.nThoofestihceoElffoegctissotf13:43 (67,1993. A3r5.ocMlaoyresM,ixBtuAr.esNeAadlm,iJnHi.s,tPeerteedrsi,nA.tCh.e, DHiaemtitlotoSnp,raS.g5u.,c-MDcaCwonkneeylRla,tEsEf.oranSidxMMooonrteh,sJ.AT.hoeCxhirconoilcoTgoixisctity of 14371 (1438), 1094. R3e6.spHoandsleesy.,JT.hG.e,TMocxCiocnolnoeglils,t LE1.4:a4n2d0 J(1o6h6n5s)o,n1,9N9.4F.. FiberInhalation Studies, Lung Burdens and Biological C3h7.rysMoctCiolnenealnld,CErEo.cidHoelsitteerbAesrbge,stTo-sW.inHtahdeleLyu,nJg.Gs. oafnRdatMsusasfteelrmIannh,alRa.tiAonC.oTmhpeaTroixsicoonloogfitshte E1f4f:e4c2tis(o1f666), 1991. `3A8r.ocMlaoryemsi,xtBuAr.esNeaadlm,inBiHs.terPeetderisn,tAh.eC.d,icHtatmoltSopnra,g5u.e8,-DMacwCloenynrealtls,fEoEr.twaenldveMomoornet,hsJ.A.TThCoehxriocnoiclotgoxiiccist.y of 1995. 39. McConnell, EEE. Letter to Editor: Cambelova and Juck.Occup.Environ.Med, 52:1995. 4O0b.erHdeosrtsetrebre,rgG,. TEW.s,timMactCiongnntehlelMEaEx.imMuilmerT,olWe.rCa.t,eCdhDevoasleie(rM,TJD,)Evfoerriat,FiJb,erThCehvreonnaizc,IPn.h,aFllaetiisosneSr,tuHd,y iannd Rodents. The Toxicologist, 30:41, 1996. 44. McConnell, EE, Miiller, W., Hesterberg, T.W., Thevenaz, P. and Axten, C. A comparison of the effects of chrysotile and amasite asbestos in hamsters afterinhalation: Interim results.TThoexicologist, 36:6 (33), 1997. 45. Hesterberg,TW., McConnell, EE, Miille, W., Chevalier, I., Everitt,J.Thevenaz, P., Fleissner,H., Hart, G. and Oberdorster, G. Subchronic inhalation study of fibrous glass in the Syriangolden hamster. The Toxicologist, 36:6 (35), 1997. 46. Mayes, B.A., Neal, BH. Peters, A.C., Brown, J. F., Hamilton, 5, McConnell, EE. and Moore,JA. Tumor responsiens Sprague-Dawleyrats fed Arochlors 1016, 1042 1251 and 1260 for twoyears. The Toxicologist, 36:158 (804), 1997. o47n.coMgceCnoincneelflf,ecEtEsEo,fMvialrleiro,usW.t,ypHeesstoefrbaesrbge,stTo.sW.i,nTrhoedveenntasz,aftP.eranlidfeAtsitmeeni,nhCa.lAaticoonm.pTTahoreixsiocnolofogthiest, 42:17 (876), 1998. 48. Hesterberg, T.W., Axten, C., Hodley,J, McConnell, EE, Miler, W., Chevalier, J, Everitt, J, Thevenaz, P. ausnidngObSeyrrdaonrsgtoelrd,eGn.hEasmtsitmeartsi.nTghotehxeicmoalxoigmiusmt,to4l2e:ra1t7e7d(d8o77s)e,o1f9f9i8b.er glass for a chronic inhalation study 49. Axten, C., McComell. EE. Hesterberg,T.W. Hadley,1.G.. Miler, W.. Thevenaz, P.andChevalier,J. Chronic inhalation toxicityof(wo typesoffobrous glassand amasite asbestosasbestosinSyrian goldenhamsters.Tohexicologist, 42:17 (880), 1998. 50. Kamstrup, O., Davis, 1M.G., Fllenhauge, A. and Guldberg, M. Pathogenicity ofman-made vitreous fibers. after longterm inhalation.Thoexicologist, 48(1-5), 1999. 51. McConnell, EE. Use of the rodent diaphragm and thoracic wall o determine transpleural migration of `AMbaearsstraifcthetr, iTnhhealNaettihoenrleaxnpdoss.ur1e3.-P1r5oOcceteodibnegrs1o9f99t.he 7% International Symposium on Particle Toxicology. g5o2.ldMecnCohnanmcsltle,rsE.E.PrAocceoemdpianrgissoofntohfep7leuIrnatlermneastoiotnhaallSioymmapsosiniduumceodnbPyaratiscbleesTtooxsiaconldogSyV.-4M0aavsitrruischitn,STyhriean Netherknds. 13-15 October 1999. 53. Axten, C.W., Hadley, J, Hesterberg, T., McConnell, EE. and Miiller. Fiberbiopersistence asanindicator ofporential pathophysiology - Results of a chronic inhalation study. Proceedings of the 7*International Symposium on ParticleToxicology. Maastricht, The Netherlands. 13-15 October 1999. D54o.ttTi,heAv.eInnafzl,uePnhc,eJoofnemse,thAoDdo,lMoiglyleor,nWr.e,poArxtteedn,tuCn.Wg.b,uHredsetneragenrdg,fiTb.eWr.c,oHnacdelnetyr,atJi,oMncsCfoonrneinlhla,laEtEi.onand studics with man-made fibers: Part 1 - Acrosol gencrationand exposuremethods. Proceedings ofthe 7* International Symposium on Particle Toxicology. Maastricht, The Netherlands. 13-15 October 1999. 1. "Lymphosarcoma in Domestic Animals," Armed Forces Institute ofPathology, Washington, DC, March 1966. 2. "The Clinician and Pathologist." South AfricaVAA (WITS)Congress, May 1970. 13.97"0E.xperiences with Animals at the Kruger National Park," VeterinaryFaculty, Onderstepoort, September 4P.ie"tTehresbRuorlge, oOfctaoVbeetrer1i9n7a0r.ian inthe US. AirForce." EasternTransvaal VeterinaryMedical Association, S5.ep"tAnetmhbrearx1i9n7a1n. African Buffalo from the KrugerNational Park," Congress ofthe South AfricanVMA, 61.97"2R.espiratory Acariasis in Chacma Baboons," ScienceWeek-1972, WITS University,Johannesburg, June 7o.f"tPhaethVoeltoegriicnaalryObRseesrevaartcihonIsnsitnitu1t0e0, BOnadbeorosntsepforoormt,thJeulKyru1g9e7r2National Park,"Veterinary Faculty and Staff I8.ns"tLietsutieoonfsiPnatPhroelco-gRya,ngSienpgtBeambboeorns1,9"72P.athology ofthe Discases ofLaboratoryAnimals, Armed Forces T9.ox"iLceoslioognys,FWoruignhdt-iPnaAtntiemraslonsAEFxBp,osSeedptteomCboearl1T9a7r3.Aerosols," 4thAnnual Conference onEnvironmental A10n.to"nAinot,hTrXa,x DinecaenmAbferric1an97B3u.ffalo." AmericanCollege ofVeterinaryPathologistsAnnualMeeting, San o11f.To"xTihceoCloomgypaArnantuiavleNTeocxticiintgy,oAftlCahnltoar,iGnAa,teMdaDricbhen1z9o7-6p.-dioxin Isomers in Mice and GuineaPigs," Society 12. "TheToxicopathology ofTCDD," Workshop onTCDD, Milan, Italy, October 1976. U13n.iv"eTrosxiitcyoloofgCiaclailfoRrensieaa,rDcahviPsr,oOgcrtaombserat1t9h7e7.National Institute ofEnvironmentalHealth Sciences," O14c.to"bTerarin19i7n7g.ofComparative Pathologists for a Carcer inToxicology," University ofCalifornia, Davis, a15n.d"NEaxpqhutishiatleenTeosx,i"cit1y7tihn AtnhenuGaulinMeeaetPiingg,toSSotcriuecttyuoraflTloyxSiicmoilloagry,HaSlaongFernaantceidscDoi,oxCiAn,s,MaFurrcahns1,97B8i.phenyls `1W9a.s"hCionmgptoanr,atDiCv,eMTaoxyic1i9t7y.of Related Halogenated Hydrocarbons." ArmedForces Institute ofPathology, 2G0r.ou"TphoenToEsnivciorloongmyenotfaDlibCaernczionfougreanenssias,ndNaDtiiboennazlodCiaonxcienrs.I"ns4t5ittuhteM,eBeettihnegsdoaf,tMheD,InMtaeryag1e9n7c9y.Collaborative 2N1o.rt"hCoCmapraorlaintaiSvteaTtoexiUcniitvyerosfitTye,chRanlieciaglh,anNdC,AnJaulnyeti1ca9l79P.entachlorophenol inCattle," NIEHS Science Fair, 2D2i.sc"aTsheeALsessoicoinastiIonnduMceeetdibngy,RUenliavteerdsiHtayloogfeOnkaltaehdoAmrao,mNatoircmsani,n VOaKr,ioAuusguSspteci1e9s7o9.fAnimals." 1979Wildlife 2M3e.et"iEnsgs,enNtIiEaHlsS,ofReRsoeuatricnheTPraitahnogtloexiPcarokl,ogNyC,EvNalouvaetimobne,r" C1o9n79s.ensus DevelopmentofImmunotoxicology `2A4g.ri"cTuolxtiucroaplaRtehsoelaogricchaalnSdynDdervoelmoepImnednutceCdenbteyrR,eWloaotsetdeHra,lOoHg,enAautgeudsPtol1y9c8y0cl.icHydrocarbons," Ohio D2i5s.tr"iTchteINVaAtiAoLnAalSTSoexmiicnoalro,gyRaPlreoigghr,amN,C",CMoanrscerhva1t9i8v1e.TrendsinLuboratoryAnimal Science, Eighth Annual 2P6h.ih"aNlTatPcTEessttienrg;CoRnefseurletnscwei,tWhaEsmhpihnagtsoins,oDnC,BiJouanssca1ys98o1fDEHP, DEFA andButylBenzylPhthalate," o27f.th"EeffSeocctisetoyfoSfubTcoxhircoonliocgyC,hlRoersedaerccohneTrEixapnogsluerPearokn,tNhCe,FJeartniulaitryyo1f9F8e2m.aleRats," NorthCarolina Chapter `2W8a.s"hEivnagltuoant,ioDnC,ofDPeactehmobleogry1R9e8q2u.irements,"Third Annual Meeting of theAmerican College ofToxicology. 2U9S.EP"AN,IECHiSncAisnbnaetsit,oOsHF,eeNdoivnegmSbteurdy19-8H2a.msters and Rats," Summary Workshop onIngested Asbestos, F30o.r"uHmisAtnonpuaatlhoWliongtyeWroMrekeltoinagd,iAnrClainrgctionno,geVnAe,siFsebBriuoaarsysa1y9s83-.Howmuch is necessary?" The Toxicology T31o.xi"cPorolloigfyerFaotirvuemLe1s9i8o3nsAnofnutahel EWxionctreirnMeePeatnicnrge,aAsrilninMgatolne,FV3A4,4FReabtrsua-rTyhe19E8f3f.ect ofCornO1l"The 32. "Toxic Oil Syndrome," WHO Meeting, Madrid, Spain, March 1983. T3o3x.i"cAonloIgmicprPoatvheodloPgriosttosc,olCrfyosrtaBlioCaitsys,ayVAS,tuMdiacys,1"9283n.d International Sympostum ofthe Society of L3a6.ns"iDnigo,xiMnI,sDinectehembEenvrir19o8n3m.ent," Human Health and Toxicity Workshop, MichiganState University, East D3i7.be"nTzooxfiucraannsd,C"aFrecdienroapteinoinc oRfeAsmpoenrsiecsaninSoEcxipeetriiemsefnotraElxApneriimmaelnstAadlmBiinoilsogtye,reStd. DLiobueisn,zoM-Op,-dAiporxiilns19a8n4d. 3Ni8e.et"iLnegs,ioDnusrihnaAmn,iNmCa,lsApErxiplo1s9e8d4.to EDE," North Carolina Chapter ofthe SocietyofToxicology Spring 3G9A.."MSatrudcihes19o8n4.the Bioavailabilityin Guinea Pigs ofDioxin in Sofl" SocietyofToxicologyMeeting, Atlanta, 40. "NTP Program Update," EuropeanToxicology Forum, Geneva Switzerland, September 1984. 4E1n.viTrhoenmReenstaplonTsoexiocfolNoTgyP,tDoatyhteonR,ecOhoimom,eOncdtaotbieorns198o4f.the Ad HocPan," 15th Conference on M42e.etNiantgi,oWnaaslhTionxgitcoonl,ogD.yC.P,roFgebrraumaSrtyat19u8s5.and NewInftiatives," The ToxicologyForum 1985 AnnualWinter S4t3a.t"isRteilceavlaPnetrsNpoenc-tSitvaet,isAtmicearliBciaonaSstsaatyisItsiscuaelsA,s"sSocyimaptoiosni,uWmasohnilnogntgo-nt,erDm.CA.,niMmaarlchCa1r9c8i5n.ogenicity Studies: A 4B4h.opTahleTrSahgoerdty,anTdheLoWnogrkTeerrsmPHoelaiclythPraonjdectE,nvNierwoanrmke,nNtaelwIJmeprascetys,,M"aCrocnhfe1r9e8n5c.e on theImplications of the 4Un5i.e"rAsditHyocofRCeipnocritnnoantiC,hOehmiioc,aMlaCyar1c9i8n5o.genesis Testing andEvaluation," EnvironmentalHealth Seminar, 4H6i.st"oCphaatlhloelnoggeys aSenmdiOnpaprorotnurtihetiReesprfoorduPcattihvoleogSiyssttseimnofthLeaNbaotriaotnoarlyTAonxiimcaollso,gyHaPnroovgerra,m,G"eIrLmSaTny, September 1985. `4A7.na"lyTshies LJuesstiiofniscaitniotnhefoRraCt,o"mIbLiSn]iHnigstBoepnaitghnolaongdyMSaelmiignnaarntonTutmhoerRsep(roordNuocttiCvoemSbyisntienmg oTfheLamb)orinatSotratyistical `Animals, Hanover, Germany, September 1985. S48y:st"eMmetohyf)LIasboocryaatnoartyeAn-iPmraellsi,miHnaanroyvSetru,dGyeRremsaulntys,,"SIeLpSt]eHmibsetrop1a9t8h5o.logy Seminar on the Reproductive 4C9L. "DOavveirsviSeixwthofAtnhneuaNaltSioynmaploTsoixuimc,olCohgeyshPirroeg,rEanmglianntdh,eSUenpitteemdbSetrat1e9s85a.nd Findings in SelectedStudis," 53. "TheToxicityofMethyl Isocyanate in Rats and Mice," New Delhi and Madras, India, February 1086. E5v4a.l"uaRteisopno,n"sSeoctioetthyeofInTtoexgircatoiloongyofAnRneucaolmmMeenetdiantgi,oNneswofOrtlheeanAsd,HLa.o,c1P9a8n6e.lon Carcinogencsis Testing and 55. "NTP Strategy for Combining Neoplasms forEvaluation ofCarcinogenesis Studies," Office ofPesticides. & Toxic Substances Seminar Program, EPA, Washington, D.C., April 1986. 56. "EnvironmentalToxicologyin theMid-Fightics: Interfacingwith the Toxicologist," FASEB 70th Annual Meeting, St. Louis, Missouri, April 1986. 57. "NTP's Response to the Ad Hoe Panel Recommendations," FEMAAnnualMeeting, Palm Beach,Florida, April 1985. N58o.rt"hStCuadrioelsionna StthaeteToUxniicvietrysiotfyMMeitchryolbIisoolcoygaynSateem,intaherCSehreimeis,caRlalReeisgph,onNsoirbtlheCfaorrotlhienaB,hAoppraillD1i9s8a6s.ter," S5t9.ud"iOepst(iLoSnIsNfFo)r,ACghgarpeeglatHiiloln, oNforItnchidCeanrcoel:inDaa,taJ,u"neInt1r9d8i6s.ciplinary DiscussionGroup on Carcinogenicity AG0s.pe"nN,TPCoElvoarlaudaot,ioJnuloyf1E9x8p6e.rimental Studies," TheToxicology Forum 1986 Annual Summer Meeting, 61. "NTP Response to the Report of the Ad Hoc Panel on Chemical Carcinogenesis Testing and Evaluation," `The Toxicology Forum 1986 Annual Summer Meeting, Aspen, Colorado,July 1986. 6O2c.to"bIenrh,al1a9t8io6n. Study ofWollastonite in Rats." SAE's 4th Annual Colloquium on Brakes, Atlantic City, NJ, 63. "Considerations in Determining the Estimated Maximum Tolerated Dose," Pharmaceutical Manufacturers' Association Drug Safety Subsection meeting, Nashville, TN, November, 1986. 6P4r.og"rCaumr,r"en2t6tShtaAtnusnuoaflthMeeeItsisnuge, ooffMthaexSiomciucmtyToolfeTroaxtiecdolDoogsye, W(aMsThDi)ngwtitohni,nDt.hCe.UFse.brNuaatriyo,na1l98T7o.xicology 5of.G"oFveedrernamlePnetrcToexpitcioolnosgiosftsB,oaBredthCeesrdtaif,icMaDt,ioMn,a"y,Sp1r9i8n7g.Mecting and ReceptionforMembers ofAssociation 6C0h.io"rGoabveangzeeSnteudPireosduinceMrisceAsasnocdiaRtaitos,n"),PaWraasdhiicnhgltoorno,bDe.nzCe.nJeulSyym19p8o7s.ium (Sponsored by CIT and 7109.88".Mouse Liver Tumors: The Problem," Mouse Liver Carcinogenesis Conference, Austin, TX, November, S7t1.ud"iBsi,o"loCgoyuIrssseueosninBitoshteatSitsattiicsst,icaIlntEevmaaltuiaotniaoln oAfgeRnocdyefnotrCRaersceinaorgcehniocnitCyancer, Lyon, France, December, 1988. T7o2.xiPciotlfoaglilcs iPnatChaorlcoignyo",geDneecseismbTeerst,in1g9,8"5.North Carolina State University, Graduate Course VMS 643 "Rodent R73e,se"aMracxhiTmruiamngTloeleCrhaatpetderD,osSeoc:iTethyefDoerbaRties,k"ABnraolyoskiisn,gRseIsncsatirtcuhteT,rWiaansghliengPatrokn,,NDC.,C.M,aMya,y,1918998.9 and E74n.vi"rTohnemSeenatraclhHefoarltAhd,eAqnunautaelBMioeaestsianyg Doafttah:eCSroucdieetByifoolrogEynvVierrosnumseSnttaatlistGiecos,c"heTrmaicsetrSyubasntdanHecaelstihn, Cincinnati, OH, May, 1989. W75o.rk"Asnhiompal1,BCiohaiscsaagyos,: IUL,siJunngeP,ro1t9o8c9o;lAstalanndtaI,ntGeAr,prDeeticnegmRbeesrul1t9s8,9".Regional Risk Assessment Workshops, 76. "Target Organ Toxicity in Carcinogenesis," Annual Summer Toxicology Forum, Aspen, CO, July, 1989. A77s.se"sTosxmiecnittyaTnedstMianngaagnedmeEnvatl,uaCthiuolna- bPhraocntiRcaelseCaorncsihdIenrsattiitoutnes,,"BaInngtekronka,tiTohnaaillTarnadi,nDiencgeWmobrekrsh19o8p9.on Risk 7t8h.e "SoUcpideattyeoofnTotxhiecSoelaogryc,hMfioarmAid,eFqLu,aFteebrBuiaorays,sa1y99D0a.ta: Crude BiologyVersus Statistics." Annual Meeting of 79. "Biological Effects ofDietaryRestriction: An International Conference, Washington, D.C. March 1990. 80. "Principles ofRoutc-to-Route Extrapolation," (Rapporteur), Hilton Head, SC, March 1990. L8a1.boMroalteorcyu,laNrY,MMeacrhcahni1s9m9s0,of Fiber Cytotoxicity and Carcinogenesis," Banbury Center, Cold Spring Harbor 8g2e.no"tNoTxPicCCaarrcciinnooggeennses-iIsn,teWroprrletdatHieoanlatlhPOrrogbalneimzsa,t"ioInn,teBrrnuastsieolnsa,lBWeolrgkisumh,opJ:unEear1l9y9I0n.dicators ofNon8139.90".Principles ofCarcinogenesis," School ofPharmacy, Campbell University, Buics Creek, NC, October, 8Si4m.i"laCroimtpieasraatnidvDeiRfefesrpeonncseessBienruCwaerecninCohgielnderseinsaBnidoaAsdsualytss:aIsmaplPiucnacttiioonns ofofrARgieskatAsFisresstsEmxepnots,urIeL,S"/RSI, Hunt Valley, MD, November, 1990. U87n.iv"eTrosxiityc,olMoagricehS,tu1d9i9e1s.", Man-made Mincral Fibers: Status ofHealth Risk Assessment",JohnsHopkins "8T8r.ia"nFgilbeerPaTrok,icMiatyy-1B9a9c1k.ground and Historical Perspective', SocietyofToxicologiePathologists, Research `8P9.ha"rAmnaicmoallogByiowaosrskasyhIospsu"cAs/RUesvcieowfGofRAR"i,skInAtsesrensatsimoennatl SaoncdieOtMyBo'fsRReegpuolrattoornyTitosxiAcpoplliocgaytainodn.in Regulatory Agencies", Crystal City, VA,June 1991. V90e.te"rTihnearDyesSicgine.ncCeoDnedputc.,tPaenndnsIynltvearnpiraetSattaitoenUonfivFeirbseirtTyo,xPiAc,itSyeSpttuedmiebse"r,A1.99L1..Bortree Lecture Serics, 9Fi1b.er"sF"i,beIrntTroaxmiucroallogFyibienrERxepsecriamrecnhtWaolrAknsihmoapl,s:NaRteisounlatls IonfstSittuudtieefsowriOtchcNuaptautriaolnaalndSaMfeatny-aMnaddeHeMailntehr,al Morgantown, WVA, September 1991. 9F2i.ber"sC"o,nWdourcktsahnodp:InAtpeprrproeatcahteiosntoofEIvnahlaulaattiinogn tShteudTioexsicoiftythaendToCxaircictiynoagnedniCcairtcyionfogMeannic-iMtaydoefFMiabenr-sM. ade Durham, NC, November 1991. 9F3e.br"uMaarny-1M9a9d2e.Fibers: Review ofToxicologyData", '92 Annual Toxicology Forum, Washington, D.C. 94. Invited testimonybefore the German MAK Commission on MMVF's. Munich, Germany, May 1992. 9O5f.fi"ceMafno-rMEaudreopFei,brCeosp:eVnahliadgietny,of19M-e2t0hMoadys,f1or99A2s.sessment ofCarcinogenicity ofFibres", WHO Regional 9263.S"eEpvtal1u9a9t2i.on ofReduced Protocols for CarcinogenicityTesting of Chemicals", EPA,Washington, DC, 22+ W97o.rk"sChomoppa,rSatt.iPveetePrastbhuorlgo,gFyL,of2C0hJryasnot1i9l9e3.and Crocidolite Ashestos", TIMA/NAIMA Fiber Science 9P8e.te"rRsebluartgi,onFsL,hi2p0BJeatnwe1e9n93P.ulmonary Fibrosis and Cancer", TIMA/NAIMA FiberScience Workshop, St. T9o9.xi"cTohleogTiocxiPcaotlhoogliocgyPaitnhoSlaofgeitsytAfsnse2s0s0m0enAtD.. NaNteieondaslfAorcaInddeumstyryo,f SGcoiveencren,mWeansthainngdtAocna,dDeCm,ia1'0, FReoble1o9f93. 103. "The Toxicopathology ofInhaled Fibers", Department ofPathology, Michigan State University, 3 June 1993. 104. "PeerReview in CarcinogenicityBioassays - Uses/Abuses", Society ofToxicologic Pathologists 12th International Symposium, Alexandria, VA, 28June 1993. I1n05h.alMatciCoonnnSetluld,yEoEf.SiKzacm-sstcrpaurpa,teOd.,MMauns-smealdmeanV,itR.r,eoHuesstFeirbbeerrsg,inTFWi.s,chCehrev3a4l4ie/rN,RJa.tasn.d2T4htehvIenntaezr,naPt.ioCnharlonic Congress on Occupational Health, Nice, France, 30 October 1993. 106. McConnell, EE. Invited expert testimony before theGerman Ministry ofthe Environment on MMVF's. Berlin, Germany, 9-10 December 1993. 107. McConnell, EE. "Fiberinduced pathologyin_experimental animals. Physiology and Cell Biology `Conference, University of Rochester Pulmonary and Critical CareUnit, 20December 1993. 108. McConnell, EE. "Talc: Consumer Uses and Health Perspectives" Panel Discussant, International Society ofRegulatoryToxicology and Pharmacology. Bethesda, MD, 31 Jan- 1 Feb 1994. `1m0a9d.eMcFiCbornens,elPlar.isE,E.Fr"aAncdev,an3tFaegbe.s1a9n9d4.limits ofin vivo screening tests", Assessment ofToxicity ofMan: 110. McConnell, EE. "Inhalation Studies: Methodologies Used and Current Studies", Symposiumon Synthetic Vitreous Fibers: Scientific and PublicPolicyIssues. Crystal City, VA, 2-3 March 1994. 111. McConnell, EE. "Historical Reviewof the Bioassay and Future Directions", Design and Interpretation ofAnimal Carcinogenicity Studies, Great Lakes Discussion Group of the Society ofToxicologic Pathologists, Cincinnati, OH, 24 March 1994. 112. McConnell, EE. Panel member "Workshop on Data Needs for Cancer Risk Assessment of MTBE', Baltimore, MD, 4 March 1995. 113. McConnell, EF. "MaximumToleraredDose versus Lung Burden: A Pathologists Point ofView", Particle OMvAe,rl2o0a-d30inMathrechRa1t99L5u.ng: Relevance for Human Risk Assessment. MIT Toxicology Symposium, Cambridge, 114. "Dose SelectioninInhalation Studies", U.S. EPA Workshop, Chapil Hill, NC, 9-10 May 1995. 115. "USS. EPA Science Advisory Board Dioxin Reassessment Review", Herdon,VA,15-16May 1995. 116. "FIFRA SAP Reviews, Chairman, Aquatic Risk Assessment and Mitigation, Crystal City, VA, 17July 1995. o1f19c.hrMycsCootnilneelaln,dEaE.m,osMiitleera,sbWe.s,tHoessitnerhbaemrsgt,eTr.sW.a,ftTehresvmebnaalza,tiPo.n:anIndteArxitmerne,suC.ltAs.cSoomcpiaertiysoofnToofxitchoeleofgfyects AnnualMeeting, Cincinnatti, OH, 1997. D1.2C0..3McACporninle1l9l9,7E.E. Selecting Doses for Chronic Rodent Bioassays. Brookings Institution. Washington, V1i2r1g.inMicaC,o2n8neAlplri,l,EE1.99R7e.gulatory Toxicology: lecture for "Principles ofPharmacology", Medical College of T1h2y2.roMicdClFauinnc,tiMo.n:anTdhyMrcoCiodnHnieslol,paEtEh.ol"oWgoyrkasnhdoSpeornumScHroerenmionngeMeAntahloydssis*foDruEknedoUcnriivneresDitiys,rDuuprtohrami,n tNhCe, 24 June 1997. 1A2l3e.seMncdCrioan,neVlAl,1E6EA.pUriplda1t9e98o.n the 10X Childrens SafetyFactor. Pesticide ProgramDialogue Committee, H12u4m.aMncCRoensnpeilrla,toErEy.DCiasnecaseers.anLdovNeolna-cCeaRnecseprirRaetsoproynRseesseatrocIhnIhnaslteidtFuitbeerssy,mVpaolsidiiutmy,ofSaAnntiamFael, MNoMd,el2s9 for September 1998. I1n2t5e.rnMactCioonnnaellSly.mEpEo.sAiuSmciocnncPea-rbtaiscelde TPoaxriacdoilgogmyf.oMratahsetrCilcahsts,ifTihceatNieonthoefrlSaynntdhse.t1ic3-V1i5trOecotuosbFeirbe1r9s9.97. E1x26p.erMicmCeonntnaellPla,tEhEo.loSgiymiBlraraintcihe,sNaantdioDniaslsiImnisltairtiuttiecsofofEnMveisrootnhmcelnitoamlaHseIanldtuhcSecdibenycAessb(eNsIHt)o,sRaTnPd, SNCV.402.7 October 1999. D1e27f.enMsceCoRnenseelalr,chEEI.nsAtitCuotme'psar2i0s"oAnniofmaAlsbAessbteosstoasndMeSdiimciianneVMiercutsin4g0,ILnadsuVceegdasM,esNoVt.he1l2iNoomvaseimnbeAnri1m9a9l9s.. I1n2t8e.rMnactCioonnnaellClo,nEgEr.esAsSocnicOnccceu-pbaatsieodnAaplpHreoaaltchh,rSointghaepColraes,s3if0icAautgiounsotf2S0y0n0t.hetic Vitreous Fibers. 26% 122090.1MacnCdomNnaetlilo,naElE.InFsotoittutaenodfMEonuvtihroDnimseenatsae:lAHeRaletvhieSwciLeenscieosn,s.KTNHo,rtGhJuCnareo2l0i0na1.State University, April, T13o0x.icMoclCoognynPerllo,grEaEm.BAinoiamsaslayCaRrnccseurltSst.udInisetsitoufteSoodfiFuomodNitTreicthe:noHliosgtiosritcsalanRneuvailemweaentidnRge,cNeentwNOartlieoannasl, LA, 24 June 2001. P1u3b4l.iMccPCoolnicnye.llN,ewEEY.o"rTkhAecVaadleuemyofoHfuMemdainciTnees,tiNnYgC,ofNPYe.st2i7ciFdeesb.r"uaPresyti2c0i0d2e.Testingin Humans: Ethics and I1n3t5e.nsMicvCeonWnoerlkls,hEoEp.."NHourmtahnCaDraotlainianSRtiastkeAUsnsievesrssmietny,t"9,ACpurrirle2n0t0T2o.pics inPesticide Toxicology: An 11316%.NMocrCtohnnAemlelr,icEEa.n "ISScSiXeMneceetainndgP,ol2i5tiOccstionbeHru2m0a02n.Testing ofPesticides", Pesticides in the Molecular Age. E1f3f7e.ctMsc?C"onAnTeSllD,REEEx.p"erHtoPwandeolAonnimHaela/lEtxhpEefrfiemctesntofDAastbaeAsutogsmeanndt SoyunrthUentdiecrsFitbaenrdsi(nSgVEo:f THhuemIannflHueeanlctehof Fiber Length. New York, NY. 29-30 October 2002. 1T3o8xi.cMitcyCoRnenseelalr,chEEw.it"hThHeuVmaalnueReofseHaurcmhanParTteisctiipnagn.t"s.NRWaCs/hNiAngStoCno,mmDiCt.te1e9 Moanrtchhe2U0s0e3ofThirdParty 11039E.vaMlcuCaotneneClalr,ciEnEo.ge"nIincgePsottieonntiSatlu."diIensteorfnaAtsiboensatloSsyamnpdosNoinu-mAsobnetshteosHePaalrttihcHleaszianrEdxEpvearliumaetnitoanloAfnFiimbarlosus ParticlesAssociatedwithTaconite and the Adjacent Duluth Complex. t1o40A.sMbceCsotnonseFlilb,erEsE.(A"nIinmfallueSntcuedioefs)F.i"beArsbTyepset,osSiMzeecahnadniEsxmpsosoufrTeoixnictihteyCWaonrckesrhoapn,dNChoinc-acgaon,ceILr. R1e2s-p13onJsuene 2003.