Document 85Mo6OJ8o4Vq6YjZdNYVyOdqd

I" - ;*f CONFERENCE TO REEVALUATE THE TOXICITY OF CONFERENCE, lo REEVALUATE the. . VINYL CHLORIDE, POLYVINYL CHLORIDE AND TOXICITY of..;'..VINYL CHLORIDE, i ' -i.'.y .1 POLYVINYL CHLORIDE and STRUCTURAL ANALOGUES r-cJ I ;11' 'i'' >, ' : ,, r*, ;V,i * r! s * * ty * ,. .' structural analogues ' ,'v* J - * t\>} r^ j , March 20-21,1900 t' I: 1 i ;1' NATIONAL INSTITUTES of HEALTH \ 'u\y >'r ' ; ; March 20-21,1000 I-li . i ;js>- ' vv j- * `nMlv?.1 ... j > : '|! witty ^{V;i i *t I*. > :r . V MASUR AUOITOHUIM ` ' YO ' ^ 1^!-.^ ;-{/ ''^y I' Ndtlon#! Initltutei of Health V.y/rV' , BUILDING 10 '' M..rAuditorium ; ' CLINICAL CENTER ' i O'-i'Builtilnato , . :tf,i '1 W.'tiV BETIIESDA, MARYLAND . ; t 'Al-i;.s i L: *. Clinical Canter '. I Bathatda,Maryland uI '*iftv'i'v" v, . . , t /li.' . J ' Vv* 'r. y.-" -v 1 *;L.;'7 Ii.;*- flVii T . < - . . . -i v . *;Vt'Ti',:V-V1/1'V ' ' x '* v * '\v- i'*'1 ufin*Li;! >, '* ' * / KA '3 . , t I.V/.'^-I: ;*!'hf%Vj-fRI'*V'A/!'-'.-i',,:.f . : ' r'; A, ll, i1* ` ' > i'1 : ` I'.- <V(.],*,' -o j->i *.*?. 1 j j i '1 ; iV i * jf'| 'it *. ' ,* * `v.mv v, ; 1 *. ' T* ` '! "' ,! *y'#v i* '4.t f` ,Lf/ > ; : Hv'ir ; ' '! (, t'.'F. v'-' _* .1' 3?*f " .. ^ ! CQinflnQtti-.':';-!i v! . ' , > i;.it.i u .r ; i .'-i(-,Ii . NVr , ' -r'l o,?i'-'* *'*'. '' ' Cotpwtart \ . : " 4'^] h:"' -.v Nellonal Inilltulai of Environmental Health Science! - ' .i'T'H ' .National (nitltute for Ocqiipattlonal Safety and Health , ' * V 1 , a * -< * ' .* Occupational Safaty and Health Admlnlitratlop V it' if . .* '-r'.Vv.! .i i,> .i . ` !/. * vi> Li.'^Li..- -1v: ^1 . * v- `R.'v ' | National Inslllutea ol Environmental Health Science* National Institute for Occupational Saloly and Health 'j\.t Occupational Safety and Health Administration ' i i. J, Viiv*: `.a t "I '* * *' t ? m Ol,* , i,*1' ' .i- . 98009 ts^y Jt Ar*.. % ] Thursday, March 20,1900 , H: v , 8:OOA.M. REGISTRATION/ 8:30 A.M. INTRODUCTORY REMARKS Dr, David Rall.NIEHS . mmm SESSION | - ' CARCINOGENESIS BIOASSSSAAYS OF VvIrNnYrtL. CumH.LUOHRlUIDfcEy.] MONOMER ; ` . y ,. r-.k'M Chalrperton;Dr,UmbertoSafftottl,NCI ^ * Ul_.,t FlLl-.U- l'-' ' *'?!*' SESSION II - . TOXICOLOGY STUDIES OFPOLYVINYL CHLORIDE / -/`i* 11:30 A.M. 11:45 A.M, : Chalrperton: Dr. Peter Infante, OSHA. .*) . -1 r ... V ./* 6. - Pneumoconiosis In Animals Exposed to Polyvinyl1 Chloride Dust I Dr. David Groth, NIOSH. . . , ' t' 7, Results of Carcinogenesis Bloattay of Polyvinyl ' . Chloride ' Dr. Chris Wagner, BMRC, Penarth, Wale* * Thursday, March 20,1980 SESSION III - SPUTUM CYTOLOGY OF VINYL CHLORIDE WORKERS Chairperson: Dr, Petar Infante, OSHA L 12:00 PJW. 'n '1 r<: 12:15 ?M. 7 ' 8, Results of Sputum Cytology Among Workers Exposed to Vinyl Chloride Monomer and to Polyvlnly Chloride Dr. Cetare Maltonl, Institute of Oncology and Tumor Center, Bologna . Discussion ,.. Y . 1 12:30 P,.M.fe"' \'L' U NCH SESSION IV- X MORTALITY STUDIES OF WORKERS EXPOSED TO &f, VINYL CHLORIDE : 1 Chairperson: Dr. Philip Landrlgen, NIOSH ,-V 2;00.r P^M,^,^0. Multiple Site Risk Analysis of Vinyl Chloride Related ' ft*,;' A .n \ Cancer In Workers -- Review * -$V l'b 1 0r-Pal6r *"fant#t OSHA 2;1B ,PM, ^`j^lO. Cohort Mortalittyy.SS tudy of Vinyl Chloride Workers. 'rH $ / .Dr.H.Weber, Der Staatlich* Gewerbearzt ^ F*d*nReepp,ublic Germany Zf 2:30 ,P.M.`'< t!t>i 1, .'EEppiiddeemmiioclogical Study of Vinyl Chloride Workers *i oDr-p cClark Cooper, Consultant X]V*2:4B PJWi>^,' 12. Power Considerations In Epidemiologic Studies ' -V:.1 ' ,*?' 'Vi'^;v ff v',; ff;iO0,t.Vv,innVyll CChhlloorriiddee WWoorrkkers :}f^ :;rh .Dr. Jay Beaumont, NIOSH vaJtfcOQ, P.M,-."rDiscussion^* V'* 3:15 PJM. . r Break t * - ;i r'V v ' 1 " * SESSION V- i *! LIVER AND BIOCHEMICAL CHANGES ASSOCIATED t WITH VINYL CHLORIDE Chairperson: Dr. David Groth, NIOSH 3:45 P.M. 13. Epldemtologlo Review of Hepatic Angiosarcoma In the United States Dr. Henry Falk, CDC Z80091SYd js> w i M* ^ j', ' : ..< '( >av i * *. ;.r Thundiy4 March 20,1980 - : l f- .V1, .* , . . ................ .. '4 * ' t* > ' , - ' l,. u - V i**'V I i. SM. ' , f ` * >; [l-r.Vj 4:00 PM. 14. United Kingdom Angiosarcoma Registry Dr. Peter Baxter, CDC 1 ' -.'V-.'V'/./l' 4:16 P.M. ' 16. Pathology of Vinyl Chloride Induced L-iIvver Lesions ' .VUjl?i Dr. Hans Popper, Mt. Sinai Medical School 4:30 P.M. 16. Liver Screening Tests for Vinyl Chloride Exposed Workers Dr. Carlo Temburro, University of Louisville - . 'j) -> SESSIONVI- INDUSTRIAL HYGIENE MEASUREMENTS OF ; , POLYVINYL CHLORIDE OPERATIONS . Chairperson: Mr. James Gideon, NIOSH ' ` 4:46 P.M. 17. Polyvlnly Chloride Processes and Products *- . Dr. R. Nick Wheeler, Union Carbide -* . r 6:00 P.M. 6:15 PM. 16,< Characterization of Polyvinyl Chloride Homopolymera,' 'Copolymers and Additives Mr. Jay Jones, NIOSH .ij Discussion ;.t i * > i h, *>V* * :v* ** Friday, March 21,1880 V: j ,.' ";* vv ,,'** t *- t v; * / r jj SESSION VII - MORBIDITY AND MORTALITY STUDIES OF WORKERS EXPOSED TO POLYVINYL CHLORIDE '; 8:30 AM. ! 8:46 A.M. Chairperson: Dr. R. Greenberg, University of Louisville '' J1 j` 19. Mortality Among Polyvinyl Chloride Fabricators 1- / Dr. Leonard Chlazza, Georgetown University. U' ' *'/ *: i ( , > , ' 20. Heart Disease In the Swedish Polyvinyl Chloride /FabricatingIndustry Dr. Gustavo Molina, Colombia . v' 8:00 A.M, 21. An Epidemiological Study of Respiratory Disease '. /* In United Kingdom Workers Exposed to Polyvinyl, ' Chloride Dust ,. Dr. Anthony Seaton, University of Edinburg 9:15 A.M, 22. Pneumoconiosis Induced by Polyvinyl Chloride Dust Dr. A. Amaud, Marseille, Franca Ij 9^30. A.M, i ,'V ' 23. An Epidemiologic Study of Pneumoconiosis In the ; lutian Polyvinyl Chloride Industry Dr. Gulsappe Mastrangelo, Padova, Italy 9:45 AM. ` \ 24. A Case-Control Study of Lung Cancer Among Vinyl i, Chloride-Polyvinyl Chloride Workers Dr. Richard Waxweiler, NIOSH 10:00 AM. : ' 26. Review of Pulmonary Effects of Polyvinyl Chloride f/ t . 1 ' Exposure ` Dr. Ruth Lille, Mt. Sinai Medical School ' *10:16A.M.4.:; Discussion ,'t *$10:30 aIm.; Break - . / i/.' J*. ft#*--1 f '-tl. ' V SESSION VIII - REPRODUCTIVE EFFECTS OF VINYL CHLORIDE < . * f Chairperson: Dr. Jamas Wilson, University of Cincinnati k '*:{ '. 11:00 AMi' ^v Transplacental Teratogenic Effects of Vinyl Chloride .'In Experimental Animals > - Dr. Jackie John. Dow Midland Texas, Galveston 1 f* * .;<il:46AMt .Power Considerations In Studies of Reproductive Effects Associated with Vinyl Chloride and Some . I. * ., ' . < (i \ Structural Analogues " .* ''-Jljvi'l:. v,` . * * 1 t'. t * *' Maureen Hatch, Columbia University 1 jl2:00 PM Discussion ,, 12:30 PM. LUNCH : '' SESSION IX^-r ENVIRONMENTAL EXPOSURE TO VINYL CHLORIDE- V j. r-IJf POLYVINYL CHLORIDE AND LIVER * ,4^;ANGIOSARCOMA . V .. . **!' Chairperson: Dr. .PPieier Bertazzl, Institute of Occupational -* ".-r *. i . ,* r1.. I- *' Health,Milan Ltt 1 t,O: C' Friday, March 21,1980 7,t l J.| - '! I, 2:00 P.M, 2:15 PM. 30. Fugitive Emlnlont of Vinyl Chlorlda-Polyvinyl . Chloride Or. Sutan R. Wyatt, ERA X/& '! MV * * *A 31, Case-Control Study of Liver Anglourcoma Amont) . ,'f `Y^y Resident* In New York Dr. Nichole* Vienna^ N.Y5. Department of Health SESSION X - CARCINOGENICITY OP SOME STRUCTURAL . ' V ANALOGUES OF VINYL CHLORIDE `'v.'-' * Chalrperton: Dr. Kim Hooper, Unlvertlty.of California, ' Berkeley r. . 2:30 P.M. 32. Comparative Pathology of Vinyl Chloride end Vlpyi Y Bromide Induced Liver Pathology In Animal* J&jra&vW 2:45 ., Dr. William Butey, Experimental Pathology j ' 'i? .... V i ** *{/- ` P.M,, : ;-n, ,33, Review of Experimental Carcinogenesis of Vlnyl,`^,.j\| . fV'iH ,'.Chlorlde Related Compound* i. ' l <iJft'i-ilf* Dr, Ken Chu, NCI , , < 3:00 P.M. vtl 34.*'Review of Epidemiologic Study Result* of Vinyl, Chloride Related Compounds '""' *J> '' Friday, March 21,1680 6:00 P.M. l 39. Dr. Joseph Wagoner, EOF 5:15 P.M. . .Discussion ,,'' 1 Proceedings from the Conference will be published : .! *\i't v Vv' i *f !iy' '. . *MV:. i'- , ... \\r Program Pltnnlng Comm/tfee Dr. Richard B. Everson . NIEHS, Research Triangle Park, North Carolina Dr. Peter F. Infante . OSHA, Washington, DJC.' V* :I t, >.. - Dr. Philip J. Landrlgan ' i *'*; ` NIOSH. Cincinnati, Ohio . ; : ; . . `Or'RaymondE.Shapiro ;.>:' IV f. NIEHS, Research Triangle Park, North Carolina , > r'<: :y,1 i'; Dr. Richard J. Waxweller ... ... - r ? f. NIOSH,Cincinnati, Ohio h v-. 4. ,**; fi :;X- . -i ; . I,/ - |P*, r* <* .-1 3:15 - P.M, ,? 3:30 P.M nccus anu ruDLb ncnun>j .'-SiT-VA.? r*MW- . *,-'|;`;'v;"Vif PCehna#ir/pDehrscount!st*^/lDoo-Mrnin,^iiV:-A:-nnj^t*h-!'.oocnn^vy.yRBoobbbbinlns,,t5NNI,00SS*.*HHj '.y? tf>*.i li.jJi. I..d.iw. Ali.-nk.lu.i ' ' :-r,, ; i;:.v -'. '-.*/ ! N,V. >.i > 'A . *., 1 .. i. * ;v ' . ; -:y.vv 1. t 36. Dr, Irving Sellkoff, Mt, Sinai Medical School''A `.:fd'-j-w. Y'fi . 1' : J; #.t ***; ; *" -ri, , i' . . .1 1 68009 IS'SH j*.*' - 4-U - rn. r t r**Trj-a,4* I S *> V ' ''W. W - LIST OF ATTENDEES AT VC CONFERENCE (including participants) Name 1. Abramovitz, B.J. 2. Adams , WG*F* 3. Adamson, Richard H., Dr. 4. Alarik, Lang M. 5. Anand, Vir D. 6. Anderson, Larry D. 7. Apfeldorf, Rosanne 8. Amaud, A., Dr. 9. Bader, E.J. 10. Ballou, L.H. 11. Barancik, J.X., Dr. 12. Barr, John T. 13. 'Baxter, Peter, Dr. 14. Baumslag, N., Dr. 15. Beatty, Patrick 16. Beaumont, Jay 17. Bertazzi, Pier, Dr. 18. Bierbower, George W., Dr. 19. Benya, Ted 20. Bell, Zeb G., Sc.D. 21. Berger, Jerry Affiliation Hooker Chemicals and Plastics I.C.I. Office of Science and Technology Policy N. I.H. Food and Drug Administration E.P.A. O. S.H.A. Clinique de Pneumo- phyisiologie, France Diamond Shamrock Corp. Firestone Case Western Reserve University Air Products C.D.C. H.E.W. Shell Development Co. N.I.O.S.H. Occupational Health Studies Group C.P-S.CEthyl Corporation p.p.G. Industries Shell Oil Company R&S160090 Name 22. Berger, Paul 23. Bodamer, James W. 24. Breen, Catherine ' 25. Brody, Judith 26. Bunn, William 27. Busey, William, Dr. 28. Carroll, William F. 29. Cassidy, John J. 30. Chen, C.T., Dr. 31. Chi, Ken 32. Chiazze, Leonard, Dr. 33. Chu, Ken 34. Cohen, Frances H. 35. Cooper, Clark, Dr. 36. Coppola, Joseph C. 37. Corcoran, Larry 38. Cosmides, George J., Dr. 39. Cotten, O. Paul 40. Crisorio, L.A. 41. Daigre, G-W. 42. Dedrick, R.L. 43. Diaz, Filadelfo T. 44. Dimmick, W. Fred Affiliation E.P .A. T.R.W. Environmental Engineering Co. Mannington Hills New York State Health Department Duke University Experimental Pathology Laboratories Firestone Plastics Co. Firestone Company O.S.H.A. Reliance Insurance Co. Georgetown University N.C.X. Maryland Occupational Safety and Health Consultant Pantasote, Inc. E.D.F. N.I.H. Great American Cleaning Corp. Union Carbide Corp. Dow Chemical Company N.I.H. Firestone Tire and Rubber Co. E.P.A Name 45. Downs, Tam 46. Dunnigan, Paula C., Dr. 47. Ertel, J.E. 48. Everson, Richard 49. Falk, Henry, Dr. 50. Fabrleant, Jill, Dr. 51. Farrar, Grover L. 52. Fishbein, Leon, Dr. 53. Flake, Raymond E., M.D. 54. Flint, George S. 55. Ford, Gary L. 56. Fountos, Barrett N. 57. France, Laureen 58. French, John E., Dr. 59. Froemming, Neil 60. Fukushi, Nobuo 61. Gabbett, James F. 62. Gaudette, Leo E., Dr. 63. Gideon, James 64. Goralski, Debra 65. Gherghel, Radu 66. Gottesman, Roy T., Dr. 67. Gosztonyi, R.E., Fr.M.D. 68. Gough, Robert G. 69. Greenberg, Richard A., Dr. 70. Group, Edward D., Dr. Affiliation University of Texas B. F. Goodrich Co. Pantasote, Inc. N. I.E.H.S. C. D.C. University of Texas American Hoechst Corp. Borden Chemical Co. Dow Chemical Co. Tenneco Chemicals Stauffer Chemical. Co. O. S.H.A. U.S. Brewer Association F.D.A. BNA Publications Nippon 2eon of America, Inc. Georgia Pacific T-O.M.A./P.A. N.X.O.S.H. Mobil Chemical Co. Allied Chemical Corp. Tenneco Chemical Co. Tenneco Chemical Co. Cincinnati Milicron University of Louisville Exxon Chemical Co. Name 95. Jones, Jay 96. Jones, M. Bruce 97. Kennedy, Harriett 98 Kilquor, Robert 99. Kokon, Jack 100. Kordalski, John S. 101. Knarr, Richard 102. Landrigan, Philip, Dr. 103. LaRose, George E. 104. Latmdrie, Robert W. 105. Lawrence, John R. 106. Leineweber, J.P. 107. Lilis, Ruth | 108. Lin, Chin, Dr, 109. Lloyd, J. William, Dr. / 110. Lynch, Jeremiah 111. Maltoni, Caesar, Dr. 112. Marcer, Guido 113. Marcus, William L. 114. Maroney, W.P. 115. Marrack, David 116. Mastrangelo, Guiseppe 117. McClendou, Janet S. 118. McElheny, Victor K. *4 Affiliation N.I.O.S.H. Mannington Mills N.C.I. Armstrong Cork Co. l.C.X. Americas Veterans Administration Stauffer Chemical N.I.O.S.H. Whittaker, Corp. General Tire Society of Plastics Industry Johns-Manville' Corp. Mt. Sinai School of Medicine P.D.A. O.S.H.A, Exxon Chemical Co. Instituto Di Oncologia, Bologna Instituto Di Medicina Del Cavordo E.F.A. Ball Corp. t Fort Bend Medical Division University of Padova Ja'cob-Medinger Co. Cold Spring Harbor Labs. JO &~ CT> , Name 119. McGaughy, Robert E. 120. McNamara# B.F. 121. Mekarg# Toshio . . 122. Miller# Richard A. 123. Misra, Krishna P. # Dr. 124. Molina# Gustavo 125. Montgomery# Kristie L. 126. Morris# Linda E. 127. Mubeijie# Debdas, Dr. 128. Nelson# K.W. 129. Nesbitt, Jeffrey130. Norris# J.M. 131. Olson, William A. 132. Oubre# Robert R. 133. Omenin# Gilbert S.# Dr. / 134. Palshaw, Mary W. 135. Park# Russell A. 136. Patterson, Alexander 137. Pegg; David G. 138. Perkowski, Regina F. 139. Popper, Hans, Dr. 140. Posner, Herbert S., Dr. 141. Potyondy, Istavn 142. Potyondy, Martha 143. Radike, Martha Affiliation E. P.A. U.S. Army Borden, Inc. PVC Belting Co. F. D.A. Servicio Secional Salud MediIlian, Colombia General Motors Co. N.C.I. Environmental Control Co. ASARCO Anaconda Co. Dow Chemical Co. C.F.R. Servicio Dow Chemical Co. Executive- Office of - the President Stauffer Chemical Co. Firestone Plastics Co. W.R. Grace and Co. General Motors Corp. General Food Corp. Mt. Sinai Medical School n.i.e.h.s. Dow Chemical Co. Shintell, Inc. University of Cincinnati Name 144. Rail, David, Dr. 145. Ramsey, Michael D. 146. Rauts, Rebecca 147. Renzo, Mattuissi 148. Rhoads, Russell H. 149. Rice, Jerry, Dr. 150. Ringwood, Robert C. 151. Roggi, P.E. 152. Rosensing, William 153. Rosnick, Andrea 154. Rupp, William 155. Ryerson, David W. 156. Robbins, Anthony, Dr. 157. Saffiotti, Umberto, Dr. 158. 7Saia, Bruno 159. Sauerhoff, M.W. 160. Sarokhan, Brenda 161. Scott, Kathryn 162. Seaton, Anthony, Dr. 163. Selikoff, Irving, Dr. 164. Shah, Hasmukh 165. Shapiro, Raymond, Dr. Affiliation N.X.E.H.S. Liberty Mutual Insuranc Chemical and Engineering News Occupational Health of Montedison American Haescht Film N.C.X. M. & T. Chemicals, Inc. Stauffer Chemical Co. V.A.H. Hill and Knowlton Co. Tenneco Chemicals, Inc. I.C.I. Americas N. I.O.S.H. N.C.X. Institute of Occupational Health - Italy Stauffer Chemical Co. American Cancer Society Bureau of National Affairs Institute of Occupational Medicine - Edinburgh Mt. Sinai School of Medicine Chemical Manufacturers Association N.I.E.H.S. 'V * Kane 166. Shepler, Thomas 167. Skalsky, Harry 168. Skozy, Lyman 169. Soffritti, Morando 170. Sorenson, W.R. 171. Stafford, John 172. Stanra, J.F. 173. Sun, Hee-Sik 174. Suzuki, Y., Dr. 175. Swetonic, Matthew M. 176. Tamburro, Carlo B. 177. Tanaka, Hozumi 178. Tassignon 179. Thomas, Jean C. 180. Thamka, L.M. 181. 'Torkelson, T.B. 182. Tsonges, Theordora A., Dr 183. Westendorf, Bill 184. Wharton, F.D. 185. White, Faye 186. White, George F., Jr. 187. Vainio, Harri 188. Vianna, Kicholas, Dr. 189. Wagoner, Joseph K., Dr. ** m v Affiliation General Tire and Rubber Reynolds Metals Co. Dow Chemical Co. N.l.E.B.S. Tenneco Chemicals, Inc. Imperial Chemical Industries, LTD. E.P.A. N.I.A.M.D.D. Mt. Sinai School of Medicine Bill and Knowlton, Inc. University of Louisville Kaneka America Corp. Solvay, Belgium Rhone Poulenc, France Dow Chemical Co. Dow Chemical Co. E.P.A. Monsanto Co. Continental Group, Inc. Government Research Corp. Reynolds Metals Co. Institute of Occupational Health, Finland K.Y. State Health Dept. E.D.F. I R&Sf60097 #4 0 Wane 190. Wheeler, R.N. 191. White, Lowell, D. 192. Yodeiken, Ralph 193; Yonng, Ronald 194. Zavan, Mitchell R. 195. Zimmerman, Jack E. 196. Zuk, Irena Affiliation Union Carbide Corp. ASARCO, Inc. K*X*0vSH* O.S.E.A. Hooker Chemical Co. Diamond Shamrock Co. Interdevelopment, Inc / .