Document 850xxyaJvz4qGjZjJzLbvvv8d

Research ASectioTn 508-iconformg ant HTMa L ver0soAifothnis.aeide Serum Vaccine Antibody Concentrations in Adolescents Exposed to Perfluorinated Compounds Philippe Grandjan,* Carsten Heilmann, Pal Weihe Flemming Nilsen, Ula B. Mogensen, and Esben BudsJorsensen Donae ChI aak, Wopocpia:esNlaBasaLarnesChHasogea,hCoopFsaeyHEDa:sB-- hn, sch,USA rDeepnootooff oTapitno.MUabsiee aofCI oene.lyCa ong.HoBiaSmy ona. Fa: Ks,Deak aBiactkccoasun:SPoosltaol enxeposs7e5p. ero skate stances (PASS) i soit ith owe serum concrions of pic abodics OhMEano0dmsa cJnWre6prs wvsrpeecct ts(ea1y9 dlolfnvcdeldEieFcaCosooer bbpitehirohsnawhoodowerhrehi3 eciasrola.ssEosccxiartoiconnosnc13n5i73o.nsNoaf PeEARSEarnidoonf dpiscssosdisAt dlip vRrasiun5t:mSocudmwceonrcn3irnaidons odfePEiAnS a1nhd aekantihongbeneereatllsy Fdeoclinnesd fPEAm7S potot1s3. nHdowaebvedr68,csnheictnsihond.vied te cerry room deCoomdesm,mkioslnpor11avc7s3vawreainctooannhtonomirf,ewarnne a2 nolayooffe2E0n2rHwtMoeRo1pheo.iwteoDdheiicgahpsnsoAtcsaim(:boFasDnoAhn7c2coohnmce.0mrdiPoerntseoradtoo1td3aSneovnased(aPPHE7OANSY ySTaS taohotcced wnih ode ndbyi2p5dbfoor dcycSdonocunbirnaioofnp3o3. oSfa1c0r-3a0l% cftoitoen olPeEAmS Fcw iotnidonEweItPEcAoSmeexopran a Cvoencrrsusons: Tosresusare in acon ith peau findings of PFAS immunoa curt spo lve. peor259/ IPenrtfrluoodruiconttioodnikylate substances (PFASS) hav awide range of aipngpalincdatiootnhserintvoxairnsaonidl.naind esainte:stcoasttincgosnftorinfooord wcrahp. pEixnpgosmuraertio nthasndpehrsrist0esnt cfoormp6ou0n3dhsa(sLriesntdedoi<n1waol.rl2d0w1i1d,e Piodpeumliailoongsicaasl irnsecnrsicihedononpyovaIbnlreecaednvteryseeaSs c(tGirn euxpnosded rCelsappNopens2e0a1150m:feSoacusetunirlneacnhodfiltddaheo.porde20sv1s4ae)cd.cmiimtmounnse.hesfubnecteinond.eiafniiebdody Sensitive indicator of sivaiod PEAS exposures in children eb(oGcortsatneeddricabayn mbetobal.ccro2n0ce1e2n:tnrdaGtripaornnesnuam1talc5tex3alp.oosfu2ar0g1e3se).(CarpWahpenerdneodans(10pr.be.e 2m0i1n5t)ycownichemrpaoosnnasaalt 7pooufrasc h(oGmreadndiien roacasLoci2a0o1n3s; MHoongsephsaevne cstkl 2b0e1n5)fDoecrreeasiendPaEAnSi.claporesscpdondselsstova(cKciinea:n SCUores2s0c1a5m:Ltoooiknecrreaesae ,he20r1is9k ofIcn aoddimtiomn, ienlefvcaitoendsPiEnAcShiedxipeon Gchrialndohomdchtolpit3a0l1i3z.aironeriasl (eFSxp1ouls2d0u10nkbuat thpe qu0aliatyfotf 17R03i5twpledWAe0n3T1 GUSrA. nTFkSPEOONET0S1 TFa Tl tperhadocns@hedaohladrdthley have po actuor orppootcatial comping W251 ind9 Fry 2016: Revd 6 be 2016: Ace 12 ly 2016, oPuNbmloiceshIead 2en6Jnuielyrl20w17li.h fairl:How1ever,ssosme tBogcooru4rdiSopcucall 1rpalmtpaunlyseodfBineFIrtrotinc,isSomeaoyggasoFslmeov 1 0y8o ssLondw amSo0nAy > 1he0edxpoourur(eBaasscehtssma.ent20i1n5).theBesctauudsyehsacsrruemcPtFlAySbeceonnccaelnlted DootnMaetcnfiinWhhiicghhlPyFcAoSrSrlaired,maeipnildyemrieoslpoognsiicballesftuoditees hpaeve SOampCoosune,(aGnrdansdjoemaenscttdail.es20h1a2v:eMtohgeernesteon mtosd.ele2d015to)t.alRePsEulAtSs O10mx piotvniaoldofiscesveoraflhPuAmSan,eiunkocelyiinegspsepaoerrootceiniemmsuunoo (niPamFemDu(AnP)eROd(SeC)p.orerpsiesnfioltnuaomlra.oyco2tc0a1cn2uc)r,aeaa(nPsdFeOrauAnm)a.colanncdemnoptdererafltlsiuoosnrusogdogefceasPmFotnOtaAe 4nd PROS similoaor lghly above thos reporid in exposed ShuimIalmnmp(oupnuMelacftuinGocntsiio(nnDseWnairtetKcaotflfalcl.tmea2d0n12b2)y,1m)anaynddisfpeerecnite Kniidbsodoyf cToonocnesnt:ratthieonmavianrydbceetrwmeiennanchoifenincwreiahsedsicmolnrcevancicoinnastioins ofpemcctnibaolosetxeprovsaceci1natpiioynschClaoprunaaed ablip2h0e1n3y)l.s A(lPiCbBou)ghcadnevseslo oTnesdwevorcoenslyrewsepaoknlsyeacssocmiatedawithctfP2F0A1S0S),, PanCdBacjounscinmtean.t afrltprentahteal PanEdASalyasspocoisattiaonls.PCwihexpnoisbuordeyd.idcnoontcemnatrratiilonys GraWnedehaanvetax.ien2d0o1d,our followup ofthe Froese bith cohort tioetheaageoofn13.,twwheeeenwpeomsotstalrecseenrtulym oPbEseArSvecdosnoceniicognis na2n0d1d5a,inNtoipgboednaysecnobneeccenaaltu.rsa2et0i1h5oe)n.sseaWivetahcmecaiianngetesaioanfreed7 noyuor(iGfordcaunUsdhjoenantUeicttgasnaeul.rs copoalmtpalSeeexxpaiomssmeusn3ew.e1sr9ye9st9pe)tm,irOceusltpaoprnryseevsiioniuknsevodrlev0sicnagtchbehospthrhwTbecodelolhsstanardnetB WeboadyysccoocnncceecnniutwaioiinoinasthtsT3podfoepanegn,dfeadnmedait3nh.lehycooannco,hmeictuaantthnetrxpeosnxuipre sre loves (Grandia cf al. 2012: Mogensen ct al. 2015). We Envionmenal Heth Perspectives orm Exphiobit 3716.0001 Cheenealiroenfsocousmedhoentthhoe PmEoAsSreecxepnotseuxraemsirneaftlieoctnesd n serum con 2S0p1a)r.cWaemiinnecl.udWedeaaodepernforfmoedpcroevnaartiaaltePaCBcedxpolsoegiicn "Vaeccainresanaildescotondcelrnneithne obdedlorahtieoscfcoralcalcyh pareo.c1e3 Methods tive level of 0.1 IU/mL with a doubled PFAS exposure. Using SAtubdiythPocpouhlorattoiofn656 cin was compiled from bis at the smtriucdturtahle evqouactaioonnmsodoefltshe(sMeoeg.enPsEeAnSetcoanl.cen2t0r1a5t)i,onwsewidletheer NSataionlal HHoopsiptiatlal iinnHTiosrasrhavn iinntthhee FFarooeeIslaannddssAduriing11999797 Speacimfidciancttibofdcy rlev(evlsitaht 13ay.bWoe mrodlelead1 7th3eseaamssocia3ti0on)s. Viasccciivneativocnceifnfaiciaocyn (aGrgaandijeadnipelhbalr. a20a1n2)d. cFaanrioesseach3ildmroe,n S[lSicEcEt SoTnhemotodteall ewffiechtthatsetahlefsstammeentinftoerrpsretaationnas ldavlieyncar sS ovemmentE supported HE ealscussym chiden hed e 13 eo creas in PEaSa aoa73aemngaioapdowieh lomwer bn Td tphoelis)amweerseouarcded,edalttoho1ughh badodniteironadlurviacncihnees p(rpeorjteutssipserainodd 1Mb0o0dsyBicnongcesntaractieondswat thiathaoglee,vewlhitha th1e9s3e.anItdibiodoynco,ncine4n r ouiranddjean aa t iHeactralvv.diTsH201.2).cTCohheamsntmScaihonnltgoocfoltPheuwlassiafoHeaml: wrrtiethenen 7(R4ea0ls1a001n70s1e8x,an0a%nddfoyrgecans ccnRaeoon aoan fnl1dS3Oi3MncEcRoAAmlSpll,emtoedeSalxsbponwseearnres 13 chotooremiemdbeprhweircnciaemifnotronlaonwopdexsapmiinnago,n 2"2a0n0Pd,I1t8EiaallCllooIwwiinNgng cilleculaoL n clonL ds am hc Information ror he chkn's mandatory vaccination ch vas somparion we ls apled lu mised mols 0 av clopihed,aantd ashqouecstihonnaqioutenestigeosntsmheoduictavlahcicsitmorayiaonndadcumrirenn.t 41C5T0000toheuetfcfoemctessofat a7gae?nd s1sru1mPnEeaAcSticoonncebnettrwaeteinonesxopno4se iVtsredeia sidhenceecmterhgreenpcoryevnimouoosomms.r.onBmvoaBecatuiaosn cacnaadnnswshevvthaesrcitnheaeochni(l(wgwhiihcaehg C n904t9t 5864whahsCLinRclhudeed,suanmodwpittnhgeiorooenfsruloatsamorwrederseopfalexgioarardlejsuisiosendsthfioyr ado otao pe a ot np,np gs Pen 4 PENS and cy comtons fs gevrash did 1no0t ctohntu ain fturtep heorr ihnfaoOs rnmaSntioUn o.n vaccinations thactoutldbe 12(034iiiiVv3eamnoodduTenildswdBuiesrciaannugsce1u9bboi9ct0hrmePogErsAesiSsigconon nispcnlinndteesvriwaaitoliahonnntsdhfrnoeembknnoedt.s bShionrteydaftcthseparcatriocnl. WCeampienrfioornmesdaonndlitnehnSolflorheisatcSrOcC. USoSrOeTsWeteeocgharngeiinhenaiswdesesapdres.ed theregrpersieon t{iaonnadndmanaalyssispuescintg ehirgh(-pGrerssaunredlicqulid c2h0r1o2m)atoWgirtahphybwcihth - rAandeibmeintwoee)wne-btwaahaireceyBh ieTmoSpEvtreeciboS stciohtn arleovtt felTesod(ataoisy ncspreeebosp,ys:techdcReoecmeopenaifrfiicswioiennhst CAPReestBdoutlal1tso7fhec$1a6agec1h13i3dcaeomri(bn7oa5tth7o%nTsho,eftahhned ac5o8h7ocr(t8m9e0eo%m)fbsephrea)rcptharieteincd B PEe we coat, heyy, bWhiocpr| oPvRiOdSsfwiacibnytashre mfooxsapmrovcalnatt P1E3AS,awsihhowocin gene`rSscrwuemrceonacveanitlraabtleiofnsroomf mmaajeomraplolpyreehglnoarnicnyaisdebriuphmentyhle csounm. dian serum concentration at 13 yof 67 ng/mL, a S6% decrease 0 7 3. PFOA and PENA decreased 10 a similar extent. of the threemajorcongeners wo as usen d a antindico ator ofothpe5toyta"l AtlothnosughoftthheecosrarmeleatPioEnASbetwwaesenvethnecaogev-e7 ahnadnatghe-1c3oconncseni- Serum conceofnmmaumoognlusln (5G) anibodics beeen the dient PEAS at cach age (r < 035133and e waerye moeascuray endsbystohe rvawciceinre piroo,ducnerVe(SratoaiGkclns nSeerudamnIannsrtry, | <0M6t28f1or7c)o,nchoemicalonsePcEoAnSelcaxtipoonsstpsr.evIentceodntmreaan,ingfPuCl Badcjousnt Ean in mer Jean scrum contac) pry wih 7atonassay using 2-fold dilutions ofthe serum.For both assays, Whe KIS serum PEAS concentrationast7 (r between -- ASanCdardantitoxins.oThne mIethoNds were the saas hmoseuesed for SOiaweiissnctgreu0amtsMPkeEetAwhSeodcdodsnicesnitrbaotino,ns hmeeasaunriebdoday c7o3ncenndtra1t3io3nsearned cllsogwiresBasoed omn ceprathmumlodlelinwcerrBarppeliseod.nsIaW]Aa4l. P15ERaSnicodnycecnoirniconnraaivon rithceodepaenodnentiahra3bl0enaind xseru8m fimandactoorymcomvaarianteas wwhilhlosthecrovnadneens a(Geranhdioesne<1ty1p.e d ereONoenagvdeuerc anrggel. ohrebroitdhpecahanirtFipabe aeorrldiyieodacfonAcLLeSonytr,ma12t0i0o1n7as0l3soh4ou%w)egadnhicel1e0ya3r (09.6%) chiden had abd concnraions <0.11U)mi. for Sdplhiopothwtohdeirhihaeeaaondnpfloratdtieotnandbucser,tcwraeesepneactnaiivnehlioy.odydHyoowcenovnesrc,eennoontnasl:.ch1iSl3adtarieien t13onsihn omahnytccohoonrtcuecrtnssn(1eed1)eAnn erahestwioneaxanmicny crotn,cenotrsatiHonesouckalneyseom4sr ubjofhl aidoinsvnaen nucpoh. bwoldsDoaortdheovper.Seiloifnheechadseenohfadthriecivevreyd oanwaaddnocnys Enoamena Heth Pspecives amois2 3716.0002 Tle Charofhts acon ty onion a. el pcos vue -TothS)or 7 or waTson BCoamlOmlaaAtTan oiww sewso MTOeGw uwaene mmiemnes sen wmoas nese AMMnisaemmeemaintet.y ma GaSBQ tG(EeI> HENST aMreenneds Dead amearo SENT oLroomnedy FMA TANsmmcueai3),emtn 08mmWn ie0tih sheegesls cee aWmMeSs wan oBseOtiEy ociss TTTTrooSoarAvaa,n, mIFMiaErEwEe GBMriAAriTNeSDtn mhBaEevvmceJ dHGaENemEDVe JIRAAiLAAtYT IMWSEEeIEDr bbHeoseertednss ebhDaEEavme aDdnsaoWgssntasyn oFaTas me ToEnoSn eEoDae a eEoRt ro es Fn SSoranvsoA SbnioFsoe.nFR SR 7 RTSor mwornd Imaarm WwEw sHiEamSne mWaWawaGwe ohnareshoosnseisnn wMoaw0 HesssdEioemn mmSWhaooowenn eSbnseeoiessen dWonwohwno hnnioowsiiness Seo cooboecrmenetecyaUotrhentlhs8ecc aogt. bboostrs,e sQuBesotaoidoernlsaeihrea e,aitnfmorremayi,on (e13F3.uarit1,tNdeeveeCsI,SRooobavocfS2o0o2mcamhvoideneRtdiedCrntnsIho3wAthe oF hm ad Svat aio sovemimons 50 15 3. Smid eon wes es prtoned ot whol 1 LL . ` oe i Ce eee :3 As3e2s8e,ee igl 2 1ieTi8rd3ea6d:es wl iidiESse. i PETE NE LuR d Yh S JTwEnN n7nn ELEEA E=hy e oFiiina . toysrt ee oee 8. Ste lo hog ied ty comfoes a) ch) i mod hl 135: nomena sth Peps amore 3716.0003 Taa52bi4laberycpesaioncmodelnsodfbcohines teri conscrnion3 13 sins wilh rr PEAS conscoinn 33307afi for Tolcoon S87) No boreor ERvi(12519) Nobo iorneTrRtS3h1% iy MFIARSScGomle)nraonTT7 C 990 paw 7 Ge SRO pu 7 Gwe wa paw PBoRNxS G0G505 7GS5se Tmmuaaaismds:s ooospmse aoavw mseo1s amCiamessoi ooosmomym dMan1 o3as73 smwwaemlsao ooaimmn PEiTAooSsncocoon.WSsToy m7e mows ean ome oon aw de Cs me mei sais orm 0m we aa ois ues Mans one oo TBFoRAxS Wa&o7 0OAT1DN SOTHsEITNaESs 0o0ama adadm aC8ee Tuwwaiiridsks o0ommm owdew en7sy mnmmaainlmsas: oooswsmse oePTSeorerhe atc raeOt NPepttaor PIlSe, erl ePPReecoFAeL ee mrta COhNep e erat FR OSLes gErmoeurp:geancyfroeom ror eotshuebxrjweicscteswhilatvhianugr.ccrsoencdeoiifvheadovianngnvaidsotdeodftnhse | P2.F14O:Apc=on0c0e3n8t)ratainodn s1h7o1we(d5o%ddCsI:ra1t.i1o5s,o2f.551;.47p(=9050%0C81:)f1o0r3,3 sbiooosntoefrt(hneo2E0R2sugbrojuepc)t:swanhdo.foorrcuonmkpnaorwisnoenspusropnosieds,oatfesrhoexwctlhue nEoRnpgrrooutpc,cirvesepaencitibvoeldyy.leFvuretlhnetr,hePfalFat7dDysghrooAwuepdansdatnitshiecaol-y a1n3i.ciTphaeisdedielcreegarsoeuipnsawneiebofduyrcyonscieminltarratwiionhsrebgeatrwde0enx7,ygaen,d 1s54i0g95n7iCo1fddi1s3,rc2a1t1ia2:osnoft1p.=390.9050%7)fCoIr:di05,p1h85i:bp=teh0e.sr0a2am3e)ivannod andPEAS exposure (Tac 1). groups, respectively: no other asociaions reached statistical asoMcailtiopnebertewgereesnsiaonni-dainaplfytsheesrisahnotwiebdodyacuonnifcoermrlayoinanvster1s3e SignIinftichaenciest structural equation model, we included an indie 3ThacntdentdheencPiFeAsSwecorncheeniSrcatoinognesstaiafetitrhcerxc7hyiioorn o1f3syub(jTeactbiwi2)h. foemctahmeadiaagei.dTby tahe ebxapnoslu3rseehaotw7sthyveinndietanetfifebcotdyancdonhceenoirraal ea chisttosryfoorfeaanchadddoiutbolnianlg ihnoosseiuerr,s aPnFd Oancoanppcreonxtirmaatiicaolynt2153%y linevecrsoeb,saenrdvealdl vinethPisFmAoSdsels,hFoowerdd aiisticpalalhylsaisgesnoicfiiractainotaniswnvee,rrsee ationna#2d475ydewcerreeasbefooircsaaicshtidcoaulbllyinsiggniinfisceanrtu.m HPoFwDeAverco,ncteenttarnaa.s a(tsaolcgarioounpasnidnathleeneox-cEluRsigroonupf.subTjeencdetnscwiietshowuetrdeewesaiknerginahne dainpiiearaCaontciebnotrdayticoonnsc,entwrhaitcihonsh.aednddeecdre0assedhomwpuocshitisvse.asthoa.n obbsoedryvCeodn,caelntlroautgiohnn.onFeowraasnsuigsni,fiscaonmt.e Avseercoendasmoocdeiliowintshowuetre eixapteocntse,do(nGeorfanwdhiachetv11a.s2s0a1i2s)t,icdaljluyssmiegnnitficfaonrtd(evIelloepm3e).ntAasl tdhiorutghlifocntgefreidndtihcetdfaeatcafuoalrldyipwheellriaanvdiasthhocwaegdeTaasniimibloadr,y ePrCeBoreexp,osPuCreB hwaadsnnootapopmreicdieabrleedclfufrcltero,n Ltohegseicassroecgiraetsisoinosn; wcohnecreentsriaattisotnc.allTyhseisgenitfeicnadnetnciinedsirelctoffbcetcsamweereclenaorwfaoprpatreetanntusin, aJinmail,yisensmoofstthcearseessuslhso,mwaednyodofdwschlow0ise1ercefcolrhtohseentoibhoed0.y1coUnc/emnL: anthdefnoor-PERRIgNroSup(2,5.b1:ot9h 5fo%r PCFI.OA~(3284.9.,2,--89.53)%.CFIi:na4ll1y.1ih,e e~s2.t4s) Swhoawnn). bHeoiwnegvebre,lfoow dthepclhiniicalhalydropuribtle,ecdivceoncloevmeilta(ndtatsaermuomt oobbtiaiinneeddwwiitth hthre tlsinieatrarmixeedquamtoidoenlsmodweelr.e similar 0 those et bodyaera. sndboyrpe or Tou coor (587) NoERvik a=s19) I omy. TT FIooRSsxcomenaonNGssT7 me mpairlyi owwe woee smee mnsearu o07eh oAw owls wwauss ooumse JPoEyS Ss 5287 CCmlsadesro DOswe a4ev bS1s0 aeismis 0D7imm Non ae8 oCiisasze oonms PETAooSsxcocoon.STyw0oo Disns n0e2y0 aow a2s9s maabiassr oamne Xws ue27 iouesuds ooasne FPPDENAS 47 wNuRba wmComsies: oaommms wwawl MBm1i2 osCnaewmiosn aoomaoons woweam odn3y3s ikmaasamsra ooomimee NTI oeeer o oon eORceeo a JFaS,gen FEScs c FAAea v Gr COXos e rPRt . sHpOoRts Emionmenal HealthPespectives orroiea 3716.0004 "-- ae 4c a scr PEAS coco 3 ips bod concn 7 3d 1 aed gc dc vc pion Totcoonr=) Not vik rst) TTpTt mosop T bie B SWHEII oe GRmss RW EI e Sm Ea a mor ms mTDiiammaa 9hI7aDoCHDeaEiedWn oaammm WaWasD TOnSiihleEesEs odosWas lTGsEeh iGmkekdies nooioamm ma TTbaariita m0Ci7ee mCDiUenRraDsrx ooomanne a1ba wDwaeodisrn ooooaemn maaisn eemaidnsss ooommoe non mBairma Tmbse MwieGd: dTem mO830 DTeHiIisOaL oGme mTobv heaSa noamm Ee ES eB coTl mTor e Can oo a amo Dhi isecupsrosvieoPnnEpSrosopecotivedstuddeycwresasepeforamneidhoidnyadaolpeescneantss tfyo nd "vases, `Swe. 10 tomes bape boostecr vmaccinaitions,cothoe sduoaf owerreeceonsorreodo10isreemovne tco`idsouybngrscouopn,acmeun1lit3ri.ap3ileonnreddgerce7rses:aisonedtrheea.sulaStslvosihoecwde.dstehawmtedrPiepEhAtsShiesrciiocanaaclnetlin-y tisingignainfigdceaancftreeorarseePxbFycDAi2ss5toi77foyanlfaonrsdubcjfaeoccrhtsPdFoWOuibAhloiaunyg13odfy,oexbcpootushurSeui.geastTih.-e baxly concentrations werA elesscler ar. Structuaral Scq0ua0tioTn UmoEdeSls `lSpWiroRtspEyeScthiivnoenuskgtbuhdoyodyisScacpopneacrneentetrl.ayitoAhen mfiianrjsttoetlooatebolanucci0deaPtefEnAthSSecithmeimbmpaoenrroa-l vation) sues 5 hat chile and Molen Who iH the eemreorgenceyraoonm fDoorsceurt,saWnhdiocthheariinojuariecsasredroiupthinherlnyadbmeicniass-e 3tbhoretchsotntuoddxoyofidedassniganmr,eerWpgreeesethnetrerifnoortmhcevhivosasicec(int0oe,eoxbtcthaleiurndeeboys-uiEbnjRteegcrrtfsoeruwipnhg.owhiFatodhr c3o.m2p0oa0roicsoen,swewhpeorfhoardmeowodtt praevrseesladllesdedctatlehecuasntntiioinipiacfddedreaexercleaudinign Aco7n0cedmYraicoonncsenhtaatatidonesrsbet1weendi7ffryenantd de1g3ree3.s oeWithrantitmieboadndy `with statistically significant losses in diphtheria antibody concen. trations at 13 y of 10-30% for the five PFASs. Few associations awidetvrhaenrcoebdseermvgoedtdehalefionarngga.nSt7hi-oPtwEeetAdaSnunseexcgpoaonicsveene,trsaOtiWwoinosn.otHonohweevftoerre,eiocmroaern.e oTfatihopboestiwbeleenohleeofseirnudmiviPdEuAalSPcoFnScewraastnoont,pfhre saannad,ytihse iOhsrereve,d asians may eft th. aft of the PFAS onth"eAisocuegihnitohensebeetsweesntuPdEyAaSimeexdpo0surbetannd vpraocspaencibdeadtya C2onrceirctoaopvoeetaniteindeddocPenrkk,Feapeasinhtodthye ccoommcpnilreaion eicoknorsyogfncha1nhgeps aendcmatyanco bienTheelopng teerm.ofT1heh pprreosten.t With PFAS exposure levels that likewise show decreases, multi ple regression analyses of the bivariate data sets need tobecom- ppolienmtOesnutdeuudribnyygcmIhorite-doaoddvatnfconedPmnFoedAreSvlaielnxgpo.ofspurreosxsiicmsaslmeintsyatrw.o (ABlabrocughc t1h.e.2l01i0n;iOninon thsa.lv2e00s7,ofthtehetwoPFwAiSdeSlysrsep2a.5rcy rmoealseu,reBmeecnatussmeaeyxpnoossufruelslydhuriangrciakicbtohoeicdhrirledzhokoedlexthpovasrey s(cKraulmcPtEaA, S2a0a0l%yLcisndwsoturkolm ptra.ov2i0s1)ong vpoisnabclee aortPsEeAlS cmomnurntcikoonisctye: Hkoweevlerd,u Foac UkxpdoesrFsaller tbaondy0ccorn oTnen,hleowgee-c7xpponorees .(MoRgeevenl<senntda0 2n015c),ewebocthhosaenthnoedlyy "aobil ifsserePEAS conscnion 7 0 tc nbd cocsta7oyn4s yadda sic sion Totsoonr=) Nob isk rst) ToT pa PAs ayol) TWbarrme Tome w3 LCO;amE p e W e om Gh awh E SAuiEoe aoaw Gi3i ea ae imm e e powen ox ms MF iiaa r60aaCmc oisise ome om 5GJ 3 TD3h0a0PO tomwJ ogo wins a3 Gea ams om a TmTaeraa mswflo ICBlDuiEsnSes DoomWm AmMDee SCDeynmIwss GEaoimme m0iT7h Saasaussy ooomlme oa Theira awh DGaisnoom warr JThaies aobmee 93x7 Giriass oodm rae hs an FDA.prorodnne: FIS, poresrsion <i. 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We rend callie benchmark WSduoogsugeledslteoevdelsIhattoahegesaitnipsmrtaetsteehnetthieemxmmpauognsnoieitoufvdicetlsoyfmoebasxyeprovbseeudr.teoTlhhimeiigthrsebstyhiasat S(ctUor ocfv1e0nd0s(.GtrheanprdeaividaousBofidndJinvggserosfnd2e0f13i)c.ieTth_eanpriebsoednty Tesponscs in this cohort at younger ages and therefore adds sup- PPoFrAt S10extphoesunroetiiosndtihact tsu.bstantially strengthened prevention of CTohenrcelsuasiontsh presentstudy rin cond withpeesious ndings sofuPlEASofitmhims usnvolaotxa)itccuidtteyy eaxnpollscuicldevb.y calotnhcooumgihtahnet dkencorwanseasndinScuosnpceecntetdathioonswoefbvotahciPaonE sadnudrAinntghhoS deicSs aindeby nirval sinc heonb. ooster Acknowledgments meChCnioUtsmSaels.]tHueEdoaynrizhwoaSSnscmeiesmeunnepctnpea.oslr,tNRPeadsteeibotnyniastlohneI(AN0ag3tenin6ocn0ya0lso(f0RIH8n,e3sita0il7tat5uhtt5ue()E:oISftOthIEe2nDDv1ia9srn9ooi)nc..h aSotmmmeeomonryTAeRtoCnA (ot ooroF osaBromoenn icSnonhocleumsAireocntsri.c)wsTihecehatduotphootraersesssolaelyyrerspeonfsitbhlee pfooralslrtesiouflotasnnyanodf 5Refae4CrreynH%ceersk,eoncd1Sb r cBechs ohe.d s. ooeeOcJdor tvoo5r: BHhapnOsHnSCHAtoAsAe.e rYo. 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